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Table of Contents

December 04, 2018; vol. 115 no. 49

This Week in PNAS

  • You have access
    In This Issue
    PNAS December 4, 2018 115 (49) 12319-12320; https://doi.org/10.1073/iti4918115

Letters (Online Only)

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    Incorrect policy interpretation affects conclusion on SO2 emissions by coal-fired power plants in China
    Ye Qi and Changgui Dong
    PNAS December 4, 2018 115 (49) E11429; first published November 16, 2018. https://doi.org/10.1073/pnas.1814665115
  • You have access
    Reply to Qi and Dong: Policy clarification and robustness of effects
    Valerie J. Karplus, Shuang Zhang, and Douglas Almond
    PNAS December 4, 2018 115 (49) E11430-E11431; first published November 16, 2018. https://doi.org/10.1073/pnas.1815003115

    See companion article:

    • Quantifying coal power plant responses to tighter SO2 emissions standards in China
      - Jun 18, 2018
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    Penicillins’ defined daily doses must be changed
    Florent Charra, Philippe Berthelot, and Frédérique Bergheau
    PNAS December 4, 2018 115 (49) E11432; first published November 13, 2018. https://doi.org/10.1073/pnas.1816558115
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    Reply to Charra et al.: Global longitudinal assessment of 2019 changes in defined daily doses
    Eili Y. Klein, Katie K. Tseng, Simon A. Levin, Herman Goossens, and Ramanan Laxminarayan
    PNAS December 4, 2018 115 (49) E11433-E11435; first published November 13, 2018. https://doi.org/10.1073/pnas.1817182115

    See companion article:

    • Global increase and geographic convergence in antibiotic consumption between 2000 and 2015
      - Mar 26, 2018

Opinion

Leading scientists discuss current issues.
  • You have access
    Opinion: Flood-risk reduction: Structural measures and diverse strategies
    • Front Matter
    Z. W. Kundzewicz, D. L. T. Hegger, P. Matczak, and P. P. J. Driessen
    PNAS December 4, 2018 115 (49) 12321-12325; https://doi.org/10.1073/pnas.1818227115

Retrospective

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    The varied careers of Kenneth L. Bowles
    M. Granger Morgan, Mark Overgaard, and Ann E. Bowles
    PNAS December 4, 2018 115 (49) 12326-12330; first published October 29, 2018. https://doi.org/10.1073/pnas.1816519115

Commentaries

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    Interspecific conflict structures urban avian assemblages
    Alexander Charles Lees
    PNAS December 4, 2018 115 (49) 12331-12333; first published November 26, 2018. https://doi.org/10.1073/pnas.1817912115

    See companion article:

    • Species interactions limit the occurrence of urban-adapted birds in cities
      - Nov 05, 2018
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    Environmentalism, norms, and identity
    Thomas Dietz and Cameron T. Whitley
    PNAS December 4, 2018 115 (49) 12334-12336; first published November 20, 2018. https://doi.org/10.1073/pnas.1817487115

    See companion article:

    • Diverse segments of the US public underestimate the environmental concerns of minority and low-income Americans
      - Oct 29, 2018
  • You have access
    Janzen’s mountain passes hypothesis is comprehensively tested in its fifth decade
    M. Alex Smith
    PNAS December 4, 2018 115 (49) 12337-12339; first published November 21, 2018. https://doi.org/10.1073/pnas.1817774115

    See companion article:

    • Narrow thermal tolerance and low dispersal drive higher speciation in tropical mountains
      - Nov 05, 2018
  • You have access
    What it takes for a cough to expel mucus from the airway
    Burton F. Dickey
    PNAS December 4, 2018 115 (49) 12340-12342; first published November 20, 2018. https://doi.org/10.1073/pnas.1817484115

    See companion article:

    • Roles of mucus adhesion and cohesion in cough clearance
      - Nov 12, 2018
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    ACSL6 is critical for maintaining brain DHA levels
    Raphaël Chouinard-Watkins and Richard P. Bazinet
    PNAS December 4, 2018 115 (49) 12343-12345; first published November 16, 2018. https://doi.org/10.1073/pnas.1817557115

    See companion article:

    • Acyl-CoA synthetase 6 enriches the neuroprotective omega-3 fatty acid DHA in the brain
      - Nov 06, 2018

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.
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    PNAS Plus Significance Statements
    PNAS December 4, 2018 115 (49) 12346-12348; https://doi.org/10.1073/pnas.ss11549

Physical Sciences

  • Applied Physical Sciences

    • Open Access
      Differential growth and shape formation in plant organs
      Changjin Huang, Zilu Wang, David Quinn, Subra Suresh, and K. Jimmy Hsia
      PNAS December 4, 2018 115 (49) 12359-12364; first published November 19, 2018. https://doi.org/10.1073/pnas.1811296115
    • Open Access
      Mesoscale structure, mechanics, and transport properties of source rocks’ organic pore networks
      Jeremie Berthonneau, Amaël Obliger, Pierre-Louis Valdenaire, Olivier Grauby, Daniel Ferry, Damien Chaudanson, Pierre Levitz, Jae Jin Kim, Franz-Josef Ulm, and Roland J.-M. Pellenq
      PNAS December 4, 2018 115 (49) 12365-12370; first published November 15, 2018. https://doi.org/10.1073/pnas.1808402115
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      Oscillating path between self-similarities in liquid pinch-off
      Antoine Lagarde, Christophe Josserand, and Suzie Protière
      PNAS December 4, 2018 115 (49) 12371-12376; first published November 19, 2018. https://doi.org/10.1073/pnas.1814242115
  • Biophysics and Computational Biology

    • Open Access
      Design and in vitro realization of carbon-conserving photorespiration
      Devin L. Trudeau, Christian Edlich-Muth, Jan Zarzycki, Marieke Scheffen, Moshe Goldsmith, Olga Khersonsky, Ziv Avizemer, Sarel J. Fleishman, Charles A. R. Cotton, Tobias J. Erb, Dan S. Tawfik, and Arren Bar-Even
      PNAS December 4, 2018 115 (49) E11455-E11464; first published November 20, 2018. https://doi.org/10.1073/pnas.1812605115
    • You have access
      Cats use hollow papillae to wick saliva into fur
      Alexis C. Noel and David L. Hu
      PNAS December 4, 2018 115 (49) 12377-12382; first published November 19, 2018. https://doi.org/10.1073/pnas.1809544115
    • You have access
      Probabilistic control of HIV latency and transactivation by the Tat gene circuit
      Youfang Cao, Xue Lei, Ruy M. Ribeiro, Alan S. Perelson, and Jie Liang
      PNAS December 4, 2018 115 (49) 12453-12458; first published November 19, 2018. https://doi.org/10.1073/pnas.1811195115
  • Chemistry

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      Receptor selectivity from minimal backbone modification of a polypeptide agonist
      Shi Liu, Ross W. Cheloha, Tomoyuki Watanabe, Thomas J. Gardella, and Samuel H. Gellman
      PNAS December 4, 2018 115 (49) 12383-12388; first published November 15, 2018. https://doi.org/10.1073/pnas.1815294115
    • You have access
      Elastic and Li-ion–percolating hybrid membrane stabilizes Li metal plating
      Quan Pang, Laidong Zhou, and Linda F. Nazar
      PNAS December 4, 2018 115 (49) 12389-12394; first published November 19, 2018. https://doi.org/10.1073/pnas.1809187115
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      Structural analysis of transient reaction intermediate in formic acid dehydrogenation catalysis using two-dimensional IR spectroscopy
      Yufan Zhang, Xin Chen, Bin Zheng, Xunmin Guo, Yupeng Pan, Hailong Chen, Huaifeng Li, Shixiong Min, Chao Guan, Kuo-Wei Huang, and Junrong Zheng
      PNAS December 4, 2018 115 (49) 12395-12400; first published November 19, 2018. https://doi.org/10.1073/pnas.1809342115
  • Computer Sciences

    • Open Access
      Bots increase exposure to negative and inflammatory content in online social systems
      Massimo Stella, Emilio Ferrara, and Manlio De Domenico
      PNAS December 4, 2018 115 (49) 12435-12440; first published November 20, 2018. https://doi.org/10.1073/pnas.1803470115
  • Earth, Atmospheric, and Planetary Sciences

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      Nanomagnetic properties of the meteorite cloudy zone
      Joshua F. Einsle, Alexander S. Eggeman, Ben H. Martineau, Zineb Saghi, Sean M. Collins, Roberts Blukis, Paul A. J. Bagot, Paul A. Midgley, and Richard J. Harrison
      PNAS December 4, 2018 115 (49) E11436-E11445; first published November 16, 2018. https://doi.org/10.1073/pnas.1809378115
    • Open Access
      Change in household fuels dominates the decrease in PM2.5 exposure and premature mortality in China in 2005–2015
      Bin Zhao, Haotian Zheng, Shuxiao Wang, Kirk R. Smith, Xi Lu, Kristin Aunan, Yu Gu, Yuan Wang, Dian Ding, Jia Xing, Xiao Fu, Xudong Yang, Kuo-Nan Liou, and Jiming Hao
      PNAS December 4, 2018 115 (49) 12401-12406; first published November 19, 2018. https://doi.org/10.1073/pnas.1812955115
    • You have access
      Potential shift from a carbon sink to a source in Amazonian peatlands under a changing climate
      Sirui Wang, Qianlai Zhuang, Outi Lähteenoja, Frederick C. Draper, and Hinsby Cadillo-Quiroz
      PNAS December 4, 2018 115 (49) 12407-12412; first published November 19, 2018. https://doi.org/10.1073/pnas.1801317115
    • You have access
      Large changes in biomass burning over the last millennium inferred from paleoatmospheric ethane in polar ice cores
      Melinda R. Nicewonger, Murat Aydin, Michael J. Prather, and Eric S. Saltzman
      PNAS December 4, 2018 115 (49) 12413-12418; first published November 19, 2018. https://doi.org/10.1073/pnas.1807172115
  • Environmental Sciences

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      Detecting and explaining why aquifers occasionally become degraded near hydraulically fractured shale gas wells
      • Inaugural Article
      Josh Woda, Tao Wen, David Oakley, David Yoxtheimer, Terry Engelder, M. Clara Castro, and Susan L. Brantley
      PNAS December 4, 2018 115 (49) 12349-12358; first published November 19, 2018. https://doi.org/10.1073/pnas.1809013115

      See companion article:

      • Profile of Susan Brantley
        - Dec 03, 2018

      See companion article:

      • Moving beyond forensic monitoring to understand and manage impacts of hydraulic fracturing for oil and gas development
        - Dec 11, 2018
    • Open Access
      Smoke radiocarbon measurements from Indonesian fires provide evidence for burning of millennia-aged peat
      Elizabeth B. Wiggins, Claudia I. Czimczik, Guaciara M. Santos, Yang Chen, Xiaomei Xu, Sandra R. Holden, James T. Randerson, Charles F. Harvey, Fuu Ming Kai, and Liya E. Yu
      PNAS December 4, 2018 115 (49) 12419-12424; first published November 19, 2018. https://doi.org/10.1073/pnas.1806003115

Social Sciences

  • Economic Sciences

    • Open Access
      Contrasting temporal difference and opportunity cost reinforcement learning in an empirical money-emergence paradigm
      Germain Lefebvre, Aurélien Nioche, Sacha Bourgeois-Gironde, and Stefano Palminteri
      PNAS December 4, 2018 115 (49) E11446-E11454; first published November 15, 2018. https://doi.org/10.1073/pnas.1813197115
    • You have access
      Dynamic effects of enforcement on cooperation
      Roberto Galbiati, Emeric Henry, and Nicolas Jacquemet
      PNAS December 4, 2018 115 (49) 12425-12428; first published November 19, 2018. https://doi.org/10.1073/pnas.1813502115
  • Environmental Sciences

    • You have access
      Diverse segments of the US public underestimate the environmental concerns of minority and low-income Americans
      • From the Cover
      Adam R. Pearson, Jonathon P. Schuldt, Rainer Romero-Canyas, Matthew T. Ballew, and Dylan Larson-Konar
      PNAS December 4, 2018 115 (49) 12429-12434; first published October 29, 2018. https://doi.org/10.1073/pnas.1804698115

      See companion article:

      • Environmentalism, norms, and identity
        - Nov 20, 2018
  • Social Sciences

    • Open Access
      Bots increase exposure to negative and inflammatory content in online social systems
      Massimo Stella, Emilio Ferrara, and Manlio De Domenico
      PNAS December 4, 2018 115 (49) 12435-12440; first published November 20, 2018. https://doi.org/10.1073/pnas.1803470115
    • You have access
      Generalizability of heterogeneous treatment effect estimates across samples
      Alexander Coppock, Thomas J. Leeper, and Kevin J. Mullinix
      PNAS December 4, 2018 115 (49) 12441-12446; first published November 16, 2018. https://doi.org/10.1073/pnas.1808083115

Biological Sciences

  • Biochemistry

    • Open Access
      Design and in vitro realization of carbon-conserving photorespiration
      Devin L. Trudeau, Christian Edlich-Muth, Jan Zarzycki, Marieke Scheffen, Moshe Goldsmith, Olga Khersonsky, Ziv Avizemer, Sarel J. Fleishman, Charles A. R. Cotton, Tobias J. Erb, Dan S. Tawfik, and Arren Bar-Even
      PNAS December 4, 2018 115 (49) E11455-E11464; first published November 20, 2018. https://doi.org/10.1073/pnas.1812605115
    • You have access
      Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins
      F. Donelson Smith, Mitchell H. Omar, Patrick J. Nygren, Joseph Soughayer, Naoto Hoshi, Ho-Tak Lau, Calvin G. Snyder, Tess C. Branon, Debapriya Ghosh, Lorene K. Langeberg, Alice Y. Ting, Luis F. Santana, Shao-En Ong, Manuel F. Navedo, and John D. Scott
      PNAS December 4, 2018 115 (49) E11465-E11474; first published November 19, 2018. https://doi.org/10.1073/pnas.1816614115
    • You have access
      SIR proteins create compact heterochromatin fibers
      Sarah G. Swygert, Subhadip Senapati, Mehmet F. Bolukbasi, Scot A. Wolfe, Stuart Lindsay, and Craig L. Peterson
      PNAS December 4, 2018 115 (49) 12447-12452; first published November 19, 2018. https://doi.org/10.1073/pnas.1810647115
  • Biophysics and Computational Biology

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      Molecular dynamics simulations of nucleotide release from the circadian clock protein KaiC reveal atomic-resolution functional insights
      Lu Hong, Bodhi P. Vani, Erik H. Thiede, Michael J. Rust, and Aaron R. Dinner
      PNAS December 4, 2018 115 (49) E11475-E11484; first published November 15, 2018. https://doi.org/10.1073/pnas.1812555115
    • Open Access
      Differential growth and shape formation in plant organs
      Changjin Huang, Zilu Wang, David Quinn, Subra Suresh, and K. Jimmy Hsia
      PNAS December 4, 2018 115 (49) 12359-12364; first published November 19, 2018. https://doi.org/10.1073/pnas.1811296115
    • You have access
      Probabilistic control of HIV latency and transactivation by the Tat gene circuit
      Youfang Cao, Xue Lei, Ruy M. Ribeiro, Alan S. Perelson, and Jie Liang
      PNAS December 4, 2018 115 (49) 12453-12458; first published November 19, 2018. https://doi.org/10.1073/pnas.1811195115
  • Cell Biology

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      Ubiquilin 2 modulates ALS/FTD-linked FUS–RNA complex dynamics and stress granule formation
      Elizabeth J. Alexander, Amirhossein Ghanbari Niaki, Tao Zhang, Jaya Sarkar, Yang Liu, Raja Sekhar Nirujogi, Akhilesh Pandey, Sua Myong, and Jiou Wang
      PNAS December 4, 2018 115 (49) E11485-E11494; first published November 15, 2018. https://doi.org/10.1073/pnas.1811997115
  • Ecology

    • You have access
      Species interactions limit the occurrence of urban-adapted birds in cities
      • From the Cover
      Paul R. Martin and Frances Bonier
      PNAS December 4, 2018 115 (49) E11495-E11504; first published November 5, 2018. https://doi.org/10.1073/pnas.1809317115

      See companion article:

      • Interspecific conflict structures urban avian assemblages
        - Nov 26, 2018
    • You have access
      Partitioning mortality into growth-dependent and growth-independent hazards across 203 tropical tree species
      James S. Camac, Richard Condit, Richard G. FitzJohn, Lachlan McCalman, Daniel Steinberg, Mark Westoby, S. Joseph Wright, and Daniel S. Falster
      PNAS December 4, 2018 115 (49) 12459-12464; first published November 16, 2018. https://doi.org/10.1073/pnas.1721040115
  • Evolution

    • You have access
      Loss of protein synthesis quality control in host-restricted organisms
      Sergey V. Melnikov, Antonia van den Elzen, David L. Stevens, Carson C. Thoreen, and Dieter Söll
      PNAS December 4, 2018 115 (49) E11505-E11512; first published November 19, 2018. https://doi.org/10.1073/pnas.1815992115
    • Open Access
      Testing the retroelement invasion hypothesis for the emergence of the ancestral eukaryotic cell
      Gloria Lee, Nicholas A. Sherer, Neil H. Kim, Ema Rajic, Davneet Kaur, Niko Urriola, K. Michael Martini, Chi Xue, Nigel Goldenfeld, and Thomas E. Kuhlman
      PNAS December 4, 2018 115 (49) 12465-12470; first published November 19, 2018. https://doi.org/10.1073/pnas.1807709115
    • You have access
      Narrow thermal tolerance and low dispersal drive higher speciation in tropical mountains
      • From the Cover
      Nicholas R. Polato, Brian A. Gill, Alisha A. Shah, Miranda M. Gray, Kayce L. Casner, Antoine Barthelet, Philipp W. Messer, Mark P. Simmons, Juan M. Guayasamin, Andrea C. Encalada, Boris C. Kondratieff, Alexander S. Flecker, Steven A. Thomas, Cameron K. Ghalambor, N. LeRoy Poff, W. Chris Funk, and Kelly R. Zamudio
      PNAS December 4, 2018 115 (49) 12471-12476; first published November 5, 2018. https://doi.org/10.1073/pnas.1809326115

      See companion article:

      • Janzen’s mountain passes hypothesis is comprehensively tested in its fifth decade
        - Nov 21, 2018
  • Immunology and Inflammation

    • Open Access
      The CD4−CD8− MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8+ MAIT cell pool
      Joana Dias, Caroline Boulouis, Jean-Baptiste Gorin, Robin H. G. A. van den Biggelaar, Kerri G. Lal, Anna Gibbs, Liyen Loh, Muhammad Yaaseen Gulam, Wan Rong Sia, Sudipto Bari, William Y. K. Hwang, Douglas F. Nixon, Son Nguyen, Michael R. Betts, Marcus Buggert, Michael A. Eller, Kristina Broliden, Annelie Tjernlund, Johan K. Sandberg, and Edwin Leeansyah
      PNAS December 4, 2018 115 (49) E11513-E11522; first published November 15, 2018. https://doi.org/10.1073/pnas.1812273115
    • You have access
      Excessive endosomal TLR signaling causes inflammatory disease in mice with defective SMCR8-WDR41-C9ORF72 complex function
      William McAlpine, Lei Sun, Kuan-wen Wang, Aijie Liu, Ruchi Jain, Miguel San Miguel, Jianhui Wang, Zhao Zhang, Braden Hayse, Sarah Grace McAlpine, Jin Huk Choi, Xue Zhong, Sara Ludwig, Jamie Russell, Xiaoming Zhan, Mihwa Choi, Xiaohong Li, Miao Tang, Eva Marie Y. Moresco, Bruce Beutler, and Emre Turer
      PNAS December 4, 2018 115 (49) E11523-E11531; first published November 15, 2018. https://doi.org/10.1073/pnas.1814753115
    • You have access
      Biological sex affects vaccine efficacy and protection against influenza in mice
      Ashley L. Fink, Kyrra Engle, Rebecca L. Ursin, Wan-Yee Tang, and Sabra L. Klein
      PNAS December 4, 2018 115 (49) 12477-12482; first published November 19, 2018. https://doi.org/10.1073/pnas.1805268115
    • You have access
      MARCH3 attenuates IL-1β–triggered inflammation by mediating K48-linked polyubiquitination and degradation of IL-1RI
      Heng Lin, Deng Gao, Ming-Ming Hu, Man Zhang, Xiao-Xia Wu, Lu Feng, Wen-Hua Xu, Qing Yang, Xuan Zhong, Jin Wei, Zhi-Sheng Xu, Hong-Xia Zhang, Ze-Min Song, Qian Zhou, Wen Ye, Ying Liu, Shu Li, and Hong-Bing Shu
      PNAS December 4, 2018 115 (49) 12483-12488; first published November 15, 2018. https://doi.org/10.1073/pnas.1806217115
  • Medical Sciences

    • Open Access
      Targeted exon skipping of a CEP290 mutation rescues Joubert syndrome phenotypes in vitro and in a murine model
      Simon A. Ramsbottom, Elisa Molinari, Shalabh Srivastava, Flora Silberman, Charline Henry, Sumaya Alkanderi, Laura A. Devlin, Kathryn White, David H. Steel, Sophie Saunier, Colin G. Miles, and John A. Sayer
      PNAS December 4, 2018 115 (49) 12489-12494; first published November 16, 2018. https://doi.org/10.1073/pnas.1809432115
    • Open Access
      Redox dysregulation as a link between childhood trauma and psychopathological and neurocognitive profile in patients with early psychosis
      Luis Alameda, Margot Fournier, Ines Khadimallah, Alessandra Griffa, Martine Cleusix, Raoul Jenni, Carina Ferrari, Paul Klauser, Philipp S. Baumann, Michel Cuenod, Patric Hagmann, Philippe Conus, and Kim Q. Do
      PNAS December 4, 2018 115 (49) 12495-12500; first published November 19, 2018. https://doi.org/10.1073/pnas.1812821115
    • You have access
      Roles of mucus adhesion and cohesion in cough clearance
      • From the Cover
      Brian Button, Henry P. Goodell, Eyad Atieh, Yu-Cheng Chen, Robert Williams, Siddharth Shenoy, Elijah Lackey, Nathan T. Shenkute, Li-Heng Cai, Robert G. Dennis, Richard C. Boucher, and Michael Rubinstein
      PNAS December 4, 2018 115 (49) 12501-12506; first published November 12, 2018. https://doi.org/10.1073/pnas.1811787115

      See companion article:

      • What it takes for a cough to expel mucus from the airway
        - Nov 20, 2018
  • Microbiology

    • You have access
      Model metabolic strategy for heterotrophic bacteria in the cold ocean based on Colwellia psychrerythraea 34H
      Jeffrey J. Czajka, Mary H. Abernathy, Veronica T. Benites, Edward E. K. Baidoo, Jody W. Deming, and Yinjie J. Tang
      PNAS December 4, 2018 115 (49) 12507-12512; first published November 16, 2018. https://doi.org/10.1073/pnas.1807804115
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      Artemisinin resistance phenotypes and K13 inheritance in a Plasmodium falciparum cross and Aotus model
      Juliana M. Sá, Sarah R. Kaslow, Michael A. Krause, Viviana A. Melendez-Muniz, Rebecca E. Salzman, Whitney A. Kite, Min Zhang, Roberto R. Moraes Barros, Jianbing Mu, Paul K. Han, J. Patrick Mershon, Christine E. Figan, Ramoncito L. Caleon, Rifat S. Rahman, Tyler J. Gibson, Chanaki Amaratunga, Erika P. Nishiguchi, Kimberly F. Breglio, Theresa M. Engels, Soundarapandian Velmurugan, Stacy Ricklefs, Judith Straimer, Nina F. Gnädig, Bingbing Deng, Anna Liu, Ababacar Diouf, Kazutoyo Miura, Gregory S. Tullo, Richard T. Eastman, Sumana Chakravarty, Eric R. James, Kenneth Udenze, Suzanne Li, Daniel E. Sturdevant, Robert W. Gwadz, Stephen F. Porcella, Carole A. Long, David A. Fidock, Marvin L. Thomas, Michael P. Fay, B. Kim Lee Sim, Stephen L. Hoffman, John H. Adams, Rick M. Fairhurst, Xin-zhuan Su, and Thomas E. Wellems
      PNAS December 4, 2018 115 (49) 12513-12518; first published November 19, 2018. https://doi.org/10.1073/pnas.1813386115
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      The Pseudomonas aeruginosa T6SS-VgrG1b spike is topped by a PAAR protein eliciting DNA damage to bacterial competitors
      Panayiota Pissaridou, Luke P. Allsopp, Sarah Wettstadt, Sophie A. Howard, Despoina A. I. Mavridou, and Alain Filloux
      PNAS December 4, 2018 115 (49) 12519-12524; first published November 19, 2018. https://doi.org/10.1073/pnas.1814181115
  • Neuroscience

    • Open Access
      Genetic deletion of vesicular glutamate transporter in dopamine neurons increases vulnerability to MPTP-induced neurotoxicity in mice
      Hui Shen, Rosa Anna M. Marino, Ross A. McDevitt, Guo-Hua Bi, Kai Chen, Graziella Madeo, Pin-Tse Lee, Ying Liang, Lindsay M. De Biase, Tsung-Ping Su, Zheng-Xiong Xi, and Antonello Bonci
      PNAS December 4, 2018 115 (49) E11532-E11541; first published November 15, 2018. https://doi.org/10.1073/pnas.1800886115
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      Acyl-CoA synthetase 6 enriches the neuroprotective omega-3 fatty acid DHA in the brain
      • From the Cover
      Regina F. Fernandez, Sora Q. Kim, Yingwei Zhao, Rachel M. Foguth, Marcus M. Weera, Jessica L. Counihan, Daniel K. Nomura, Julia A. Chester, Jason R. Cannon, and Jessica M. Ellis
      PNAS December 4, 2018 115 (49) 12525-12530; first published November 6, 2018. https://doi.org/10.1073/pnas.1807958115

      See companion article:

      • ACSL6 is critical for maintaining brain DHA levels
        - Nov 16, 2018
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      Arc/Arg3.1 mediates a critical period for spatial learning and hippocampal networks
      Xiaoyan Gao, Sergio Castro-Gomez, Jasper Grendel, Sabine Graf, Ute Süsens, Lars Binkle, Daniel Mensching, Dirk Isbrandt, Dietmar Kuhl, and Ora Ohana
      PNAS December 4, 2018 115 (49) 12531-12536; first published November 15, 2018. https://doi.org/10.1073/pnas.1810125115
  • Plant Biology

    • Open Access
      Interlinked regulatory loops of ABA catabolism and biosynthesis coordinate fruit growth and ripening in woodland strawberry
      Xiong Liao, Mengsi Li, Bin Liu, Miaoling Yan, Xiaomin Yu, Hailing Zi, Renyi Liu, and Chizuko Yamamuro
      PNAS December 4, 2018 115 (49) E11542-E11550; first published November 19, 2018. https://doi.org/10.1073/pnas.1812575115
    • You have access
      Resistance protein Pit interacts with the GEF OsSPK1 to activate OsRac1 and trigger rice immunity
      Qiong Wang, Yuying Li, Kazuya Ishikawa, Ken-ichi Kosami, Kazumi Uno, Shingo Nagawa, Li Tan, Jiamu Du, Ko Shimamoto, and Yoji Kawano
      PNAS December 4, 2018 115 (49) E11551-E11560; first published November 16, 2018. https://doi.org/10.1073/pnas.1813058115

Correction (Online Only)

  • You have access
    Correction for Benej et al., Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism
    PNAS December 4, 2018 115 (49) E11561; first published November 19, 2018. https://doi.org/10.1073/pnas.1818732115

SI Corrections (Online Only)

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    Correction to Supporting Information for Alix-Garcia et al., Payments for environmental services supported social capital while increasing land management
    PNAS December 4, 2018 115 (49) E11562; first published November 19, 2018. https://doi.org/10.1073/pnas.1818895115
  • You have access
    Correction to Supporting Information for Kwon et al., Coiled-coil structure-dependent interactions between polyQ proteins and Foxo lead to dendrite pathology and behavioral defects
    PNAS December 4, 2018 115 (49) E11563; first published November 19, 2018. https://doi.org/10.1073/pnas.1818885115
  • You have access
    Correction to Supporting Information for Nobori et al., Transcriptome landscape of a bacterial pathogen under plant immunity
    PNAS December 4, 2018 115 (49) E11564; first published November 19, 2018. https://doi.org/10.1073/pnas.1818862115
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Proceedings of the National Academy of Sciences: 115 (49)
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