Penicillins’ defined daily doses must be changed

Florent Charra, Philippe Berthelot, and Frédérique Bergheau
PNAS December 4, 2018 115 (49) E11432; published ahead of print November 13, 2018 https://doi.org/10.1073/pnas.1816558115

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Klein et al. (1) suggest that defined daily doses (DDDs) are not a perfect outcome measure of antibiotic prescribing, particularly for penicillins (39% of total DDDs in 2015 for broad-spectrum penicillins). We identified the same limitations as illustrated by the results of our study (2), which measured the bias of estimation for amoxicillin’s indicators (oral and i.v. administrations) and oral amoxicillin clavulanic acid’s indicator.

We identified that the DDDs for amoxicillin (oral and i.v.) and oral amoxicillin …

↵1To whom correspondence should be addressed. Email: florent.charra{at}gmail.com.

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Penicillins’ defined daily doses must be changed
Florent Charra, Philippe Berthelot, Frédérique Bergheau
Proceedings of the National Academy of Sciences Dec 2018, 115 (49) E11432; DOI: 10.1073/pnas.1816558115
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