Penicillins’ defined daily doses must be changed

Florent Charra, Philippe Berthelot, and Frédérique Bergheau
PNAS December 4, 2018 115 (49) E11432; published ahead of print November 13, 2018 https://doi.org/10.1073/pnas.1816558115

This article has letters. Please see:

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Klein et al. (1) suggest that defined daily doses (DDDs) are not a perfect outcome measure of antibiotic prescribing, particularly for penicillins (39% of total DDDs in 2015 for broad-spectrum penicillins). We identified the same limitations as illustrated by the results of our study (2), which measured the bias of estimation for amoxicillin’s indicators (oral and i.v. administrations) and oral amoxicillin clavulanic acid’s indicator.

We identified that the DDDs for amoxicillin (oral and i.v.) and oral amoxicillin …

↵1To whom correspondence should be addressed. Email: florent.charra{at}gmail.com.

View Full Text

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
Back to top
Article Alerts
Email Article
Citation Tools
Request Permissions
Penicillins’ defined daily doses must be changed
Florent Charra, Philippe Berthelot, Frédérique Bergheau
Proceedings of the National Academy of Sciences Dec 2018, 115 (49) E11432; DOI: 10.1073/pnas.1816558115
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo

You May Also be Interested in

Researchers report biparental inheritance of mitochondrial DNA in 17 members of three unrelated multigeneration families, paving the way for insights into alternative mechanisms for the treatment of inherited mitochondrial diseases. Image courtesy of Pixabay/PublicDomainPictures.
Human mitochondrial DNA can be paternally inherited
Researchers report biparental inheritance of mitochondrial DNA in 17 members of three unrelated multigeneration families, paving the way for insights into alternative mechanisms for the treatment of inherited mitochondrial diseases.
Image courtesy of Pixabay/PublicDomainPictures.
Researchers report a machine-learning approach to identify land plants at risk of extinction, suggesting that the approach can be used to guide policies aimed at allocating resources for biodiversity conservation. Image courtesy of Abbie Zimmer (Ohio State University, Columbus, OH).
Machine learning identifies plants at risk of extinction
Researchers report a machine-learning approach to identify land plants at risk of extinction, suggesting that the approach can be used to guide policies aimed at allocating resources for biodiversity conservation.
Image courtesy of Abbie Zimmer (Ohio State University, Columbus, OH).
A study explores how cats groom fur using fine structures called papillae on the surface of the tongue and presents a biologically inspired hairbrush to remove allergens from cat fur and apply medications on cat skin. Image courtesy of Candler Hobbs (Georgia Institute of Technology, Atlanta).
Fine analysis of fur grooming in cats
A study explores how cats groom fur using fine structures called papillae on the surface of the tongue and presents a biologically inspired hairbrush to remove allergens from cat fur and apply medications on cat skin.
Image courtesy of Candler Hobbs (Georgia Institute of Technology, Atlanta).
Proceedings of the National Academy of Sciences: 115 (51)
Current Issue

Submit

Jump to section