Studies reveal the mechanisms behind tumor metastasis and how to stymie it. But primary tumors still get the lion’s share of researchers’ attention.
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Klein et al. (1) suggest that defined daily doses (DDDs) are not a perfect outcome measure of antibiotic prescribing, particularly for penicillins (39% of total DDDs in 2015 for broad-spectrum penicillins). We identified the same limitations as illustrated by the results of our study (2), which measured the bias of estimation for amoxicillin’s indicators (oral and i.v. administrations) and oral amoxicillin clavulanic acid’s indicator.
We identified that the DDDs for amoxicillin (oral and i.v.) and oral amoxicillin …
↵1To whom correspondence should be addressed. Email: florent.charra{at}gmail.com.
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Penicillins’ defined daily doses must be changed
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