Table of Contents

Biological Sciences

• Biochemistry

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    K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains

    Fumiaki Ohtake, Hikaru Tsuchiya, Yasushi Saeki, and Keiji Tanaka

    PNAS February 13, 2018 115 (7) E1401-E1408; first published January 29, 2018. https://doi.org/10.1073/pnas.1716673115
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    Identification of Wiskott-Aldrich syndrome protein (WASP) binding sites on the branched actin filament nucleator Arp2/3 complex

    Qing Luan, Alex Zelter, Michael J. MacCoss, Trisha N. Davis, and Brad J. Nolen

    PNAS February 13, 2018 115 (7) E1409-E1418; first published January 31, 2018. https://doi.org/10.1073/pnas.1716622115
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    Molecular basis for the recognition of the human AAUAAA polyadenylation signal

    Yadong Sun, Yixiao Zhang, Keith Hamilton, James L. Manley, Yongsheng Shi, Thomas Walz, and Liang Tong

    PNAS February 13, 2018 115 (7) E1419-E1428; first published December 5, 2017. https://doi.org/10.1073/pnas.1718723115
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    High integrin α_Vβ₆ affinity reached by hybrid domain deletion slows ligand-binding on-rate

    Xianchi Dong, Bo Zhao, Fu-Yang Lin, Chafen Lu, Bruce N. Rogers, and Timothy A. Springer

    PNAS February 13, 2018 115 (7) E1429-E1436; first published January 29, 2018. https://doi.org/10.1073/pnas.1718662115
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    Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer

    Breyan Ross, Stephan Krapp, Martin Augustin, Reiner Kierfersauer, Marcelino Arciniega, Ruth Geiss-Friedlander, and Robert Huber

    PNAS February 13, 2018 115 (7) E1437-E1445; first published January 30, 2018. https://doi.org/10.1073/pnas.1717565115

• Biophysics and Computational Biology

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    Mechanism of inhibition of retromer transport by the bacterial effector RidL

    Jialin Yao, Fan Yang, Xiaodong Sun, Shen Wang, Ninghai Gan, Qi Liu, Dingdong Liu, Xia Zhang, Dawen Niu, Yuquan Wei, Cong Ma, Zhao-Qing Luo, Qingxiang Sun, and Da Jia

    PNAS February 13, 2018 115 (7) E1446-E1454; first published January 31, 2018. https://doi.org/10.1073/pnas.1717383115
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    Lysosomal enzyme tripeptidyl peptidase 1 destabilizes fibrillar Aβ by multiple endoproteolytic cleavages within the β-sheet domain

    Santiago Solé-Domènech, Ana V. Rojas, Gia G. Maisuradze, Harold A. Scheraga, Peter Lobel, and Frederick R. Maxfield

    PNAS February 13, 2018 115 (7) 1493-1498; first published January 29, 2018. https://doi.org/10.1073/pnas.1719808115
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    Assembly mechanism of the CARMA1–BCL10–MALT1–TRAF6 signalosome

    Liron David, Yang Li, Jun Ma, Ethan Garner, Xinzheng Zhang, and Hao Wu

    PNAS February 13, 2018 115 (7) 1499-1504; first published January 30, 2018. https://doi.org/10.1073/pnas.1721967115
  • Open Access

    Method to generate highly stable D-amino acid analogs of bioactive helical peptides using a mirror image of the entire PDB

    Michael Garton, Satra Nim, Tracy A. Stone, Kyle Ethan Wang, Charles M. Deber, and Philip M. Kim

    PNAS February 13, 2018 115 (7) 1505-1510; first published January 29, 2018. https://doi.org/10.1073/pnas.1711837115
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    High-resolution structure prediction of β-barrel membrane proteins

    Wei Tian, Meishan Lin, Ke Tang, Jie Liang, and Hammad Naveed

    PNAS February 13, 2018 115 (7) 1511-1516; first published January 29, 2018. https://doi.org/10.1073/pnas.1716817115

• Cell Biology

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    Superresolution imaging of individual replication forks reveals unexpected prodrug resistance mechanism

    Therese Triemer, Alessandra Messikommer, Stella M. K. Glasauer, Jawad Alzeer, Miriam H. Paulisch, and Nathan W. Luedtke

    PNAS February 13, 2018 115 (7) E1366-E1373; first published January 29, 2018. https://doi.org/10.1073/pnas.1714790115
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    Structure of the fission yeast actomyosin ring during constriction

    • From the Cover

    Matthew T. Swulius, Lam T. Nguyen, Mark S. Ladinsky, Davi R. Ortega, Samya Aich, Mithilesh Mishra, and Grant J. Jensen

    PNAS February 13, 2018 115 (7) E1455-E1464; first published January 18, 2018. https://doi.org/10.1073/pnas.1711218115

    See companion article:

    • Actin filament structure in the contractile ring

      - Jan 31, 2018
  • Open Access

    LncRNA IDH1-AS1 links the functions of c-Myc and HIF1α via IDH1 to regulate the Warburg effect

    Shaoxun Xiang, Hao Gu, Lei Jin, Rick F. Thorne, Xu Dong Zhang, and Mian Wu

    PNAS February 13, 2018 115 (7) E1465-E1474; first published January 29, 2018. https://doi.org/10.1073/pnas.1711257115
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    RGMb protects against acute kidney injury by inhibiting tubular cell necroptosis via an MLKL-dependent mechanism

    Wenjing Liu, Binbin Chen, Yang Wang, Chenling Meng, Huihui Huang, Xiao-Ru Huang, Jinzhong Qin, Shrikant R. Mulay, Hans-Joachim Anders, Andong Qiu, Baoxue Yang, Gordon J. Freeman, Hua Jenny Lu, Herbert Y. Lin, Zhi-Hua Zheng, Hui-Yao Lan, Yu Huang, and Yin Xia

    PNAS February 13, 2018 115 (7) E1475-E1484; first published January 30, 2018. https://doi.org/10.1073/pnas.1716959115
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    Arabidopsis mRNA decay landscape arises from specialized RNA decay substrates, decapping-mediated feedback, and redundancy

    Reed S. Sorenson, Malia J. Deshotel, Katrina Johnson, Frederick R. Adler, and Leslie E. Sieburth

    PNAS February 13, 2018 115 (7) E1485-E1494; first published January 31, 2018. https://doi.org/10.1073/pnas.1712312115
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    Disease-causing mutation in α-actinin-4 promotes podocyte detachment through maladaptation to periodic stretch

    Di Feng, Jacob Notbohm, Ava Benjamin, Shijie He, Minxian Wang, Lay-Hong Ang, Minaspi Bantawa, Mehdi Bouzid, Emanuela Del Gado, Ramaswamy Krishnan, and Martin R. Pollak

    PNAS February 13, 2018 115 (7) 1517-1522; first published January 29, 2018. https://doi.org/10.1073/pnas.1717870115
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    ATR-Chk1 activation mitigates replication stress caused by mismatch repair-dependent processing of DNA damage

    Dipika Gupta, Bo Lin, Ann Cowan, and Christopher D. Heinen

    PNAS February 13, 2018 115 (7) 1523-1528; first published January 29, 2018. https://doi.org/10.1073/pnas.1720355115
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    Family with sequence similarity 13, member A modulates adipocyte insulin signaling and preserves systemic metabolic homeostasis

    Donytra Arby Wardhana, Koji Ikeda, Agian Jeffilano Barinda, Dhite Bayu Nugroho, Kikid Rucira Qurania, Keiko Yagi, Keishi Miyata, Yuichi Oike, Ken-ichi Hirata, and Noriaki Emoto

    PNAS February 13, 2018 115 (7) 1529-1534; first published January 31, 2018. https://doi.org/10.1073/pnas.1720475115

• Developmental Biology

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    Effects of rapamycin on growth hormone receptor knockout mice

    Yimin Fang, Cristal M. Hill, Justin Darcy, Adriana Reyes-Ordoñez, Edwin Arauz, Samuel McFadden, Chi Zhang, Jared Osland, John Gao, Tian Zhang, Stuart J. Frank, Martin A. Javors, Rong Yuan, John J. Kopchick, Liou Y. Sun, Jie Chen, and Andrzej Bartke

    PNAS February 13, 2018 115 (7) E1495-E1503; first published January 29, 2018. https://doi.org/10.1073/pnas.1717065115
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    Endocrine regulation of airway clearance in Drosophila

    Do-Hyoung Kim, Young-Joon Kim, and Michael E. Adams

    PNAS February 13, 2018 115 (7) 1535-1540; first published January 31, 2018. https://doi.org/10.1073/pnas.1717257115

• Ecology

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    On the complex dynamics of savanna landscapes

    Jonathan David Touboul, Ann Carla Staver, and Simon Asher Levin

    PNAS February 13, 2018 115 (7) E1336-E1345; first published January 29, 2018. https://doi.org/10.1073/pnas.1712356115
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    Alarm calls evoke a visual search image of a predator in birds

    • From the Cover

    Toshitaka N. Suzuki

    PNAS February 13, 2018 115 (7) 1541-1545; first published January 29, 2018. https://doi.org/10.1073/pnas.1718884115
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    Coprolites reveal ecological interactions lost with the extinction of New Zealand birds

    • From the Cover

    Alexander P. Boast, Laura S. Weyrich, Jamie R. Wood, Jessica L. Metcalf, Rob Knight, and Alan Cooper

    PNAS February 13, 2018 115 (7) 1546-1551; first published February 12, 2018. https://doi.org/10.1073/pnas.1712337115

    See companion article:

    • Moa parasite extinctions

      - Feb 12, 2018

• Evolution

  • Open Access

    Farming the mitochondrial ancestor as a model of endosymbiotic establishment by natural selection

    István Zachar, András Szilágyi, Szabolcs Számadó, and Eörs Szathmáry

    PNAS February 13, 2018 115 (7) E1504-E1510; first published January 30, 2018. https://doi.org/10.1073/pnas.1718707115

    See companion article:

    • Reply to Garg and Martin: The mechanism works

      - May 03, 2018
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    Immunogenetic novelty confers a selective advantage in host–pathogen coevolution

    Karl P. Phillips, Joanne Cable, Ryan S. Mohammed, Magdalena Herdegen-Radwan, Jarosław Raubic, Karolina J. Przesmycka, Cock van Oosterhout, and Jacek Radwan

    PNAS February 13, 2018 115 (7) 1552-1557; first published January 16, 2018. https://doi.org/10.1073/pnas.1708597115

    See companion article:

    • Adaptive value of novel MHC gene variants

      - Jan 31, 2018

• Genetics

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    Loss of Capicua alters early T cell development and predisposes mice to T cell lymphoblastic leukemia/lymphoma

    Qiumin Tan, Lorenzo Brunetti, Maxime W. C. Rousseaux, Hsiang-Chih Lu, Ying-Wooi Wan, Jean-Pierre Revelli, Zhandong Liu, Margaret A. Goodell, and Huda Y. Zoghbi

    PNAS February 13, 2018 115 (7) E1511-E1519; first published January 30, 2018. https://doi.org/10.1073/pnas.1716452115
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    De novo mutation in RING1 with epigenetic effects on neurodevelopment

    Sarah B. Pierce, Mikaela D. Stewart, Suleyman Gulsuner, Tom Walsh, Abhinav Dhall, Jon M. McClellan, Rachel E. Klevit, and Mary-Claire King

    PNAS February 13, 2018 115 (7) 1558-1563; first published January 31, 2018. https://doi.org/10.1073/pnas.1721290115
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    Sirt4 is a mitochondrial regulator of metabolism and lifespan in Drosophila melanogaster

    Jason G. Wood, Bjoern Schwer, Priyan C. Wickremesinghe, Davis A. Hartnett, Lucas Burhenn, Meyrolin Garcia, Michael Li, Eric Verdin, and Stephen L. Helfand

    PNAS February 13, 2018 115 (7) 1564-1569; first published January 29, 2018. https://doi.org/10.1073/pnas.1720673115
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    Disruption of the ciliary GTPase Arl13b suppresses Sonic hedgehog overactivation and inhibits medulloblastoma formation

    Sarah N. Bay, Alyssa B. Long, and Tamara Caspary

    PNAS February 13, 2018 115 (7) 1570-1575; first published January 29, 2018. https://doi.org/10.1073/pnas.1706977115

• Immunology and Inflammation

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    Male-specific IL-33 expression regulates sex-dimorphic EAE susceptibility

    Abigail E. Russi, Mark E. Ebel, Yuchen Yang, and Melissa A. Brown

    PNAS February 13, 2018 115 (7) E1520-E1529; first published January 29, 2018. https://doi.org/10.1073/pnas.1710401115
  • Open Access

    OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation

    Carlo Marchetti, Benjamin Swartzwelter, Fabia Gamboni, Charles P. Neff, Katrin Richter, Tania Azam, Sonia Carta, Isak Tengesdal, Travis Nemkov, Angelo D’Alessandro, Curtis Henry, Gerald S. Jones, Scott A. Goodrich, Joseph P. St. Laurent, Terry M. Jones, Curtis L. Scribner, Robert B. Barrow, Roy D. Altman, Damaris B. Skouras, Marco Gattorno, Veronika Grau, Sabina Janciauskiene, Anna Rubartelli, Leo A. B. Joosten, and Charles A. Dinarello

    PNAS February 13, 2018 115 (7) E1530-E1539; first published January 29, 2018. https://doi.org/10.1073/pnas.1716095115
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    Anti–PD-1/anti–CTLA-4 efficacy in melanoma brain metastases depends on extracranial disease and augmentation of CD8⁺ T cell trafficking

    David Taggart, Tereza Andreou, Karen J. Scott, Jennifer Williams, Nora Rippaus, Rebecca J. Brownlie, Elizabeth J. Ilett, Robert J. Salmond, Alan Melcher, and Mihaela Lorger

    PNAS February 13, 2018 115 (7) E1540-E1549; first published January 31, 2018. https://doi.org/10.1073/pnas.1714089115
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    Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration

    • Cozzarelli Prize Winner

    Nathalie Cloutier, Isabelle Allaeys, Genevieve Marcoux, Kellie R. Machlus, Benoit Mailhot, Anne Zufferey, Tania Levesque, Yann Becker, Nicolas Tessandier, Imene Melki, Huiying Zhi, Guy Poirier, Matthew T. Rondina, Joseph E. Italiano, Louis Flamand, Steven E. McKenzie, Francine Cote, Bernhard Nieswandt, Waliul I. Khan, Matthew J. Flick, Peter J. Newman, Steve Lacroix, Paul R. Fortin, and Eric Boilard

    PNAS February 13, 2018 115 (7) E1550-E1559; first published January 31, 2018. https://doi.org/10.1073/pnas.1720553115
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    Holo-lipocalin-2–derived siderophores increase mitochondrial ROS and impair oxidative phosphorylation in rat cardiomyocytes

    Erfei Song, Sofhia V. Ramos, Xiaojing Huang, Ying Liu, Amy Botta, Hye Kyoung Sung, Patrick C. Turnbull, Michael B. Wheeler, Thorsten Berger, Derek J. Wilson, Christopher G. R. Perry, Tak W. Mak, and Gary Sweeney

    PNAS February 13, 2018 115 (7) 1576-1581; first published January 29, 2018. https://doi.org/10.1073/pnas.1720570115
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    Targeting JAK2 reduces GVHD and xenograft rejection through regulation of T cell differentiation

    Brian C. Betts, David Bastian, Supinya Iamsawat, Hung Nguyen, Jessica L. Heinrichs, Yongxia Wu, Anusara Daenthanasanmak, Anandharaman Veerapathran, Alison O’Mahony, Kelly Walton, Jordan Reff, Pedro Horna, Elizabeth M. Sagatys, Marie C. Lee, Jack Singer, Ying-Jun Chang, Chen Liu, Joseph Pidala, Claudio Anasetti, and Xue-Zhong Yu

    PNAS February 13, 2018 115 (7) 1582-1587; first published January 30, 2018. https://doi.org/10.1073/pnas.1712452115
  • Open Access

    Mast cells promote small bowel cancer in a tumor stage-specific and cytokine-dependent manner

    Abdulrahman M. Saadalla, Abu Osman, Michael F. Gurish, Kristen L. Dennis, Nichole R. Blatner, Abdulmohammad Pezeshki, Kelly M. McNagny, Hilde Cheroutre, Fotini Gounari, and Khashayarsha Khazaie

    PNAS February 13, 2018 115 (7) 1588-1592; first published February 2, 2018. https://doi.org/10.1073/pnas.1716804115

• Medical Sciences

  • Open Access

    E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells

    • From the Cover

    Hyun-Wook Lee, Sung-Hyun Park, Mao-wen Weng, Hsiang-Tsui Wang, William C. Huang, Herbert Lepor, Xue-Ru Wu, Lung-Chi Chen, and Moon-shong Tang

    PNAS February 13, 2018 115 (7) E1560-E1569; first published January 29, 2018. https://doi.org/10.1073/pnas.1718185115

    See companion article:

    • Reply to Li Volti et al.: E-cigarette smoke exposure and effect in mice and human cells

      - Mar 13, 2018
    • Reply to Queimado et al.: E-cigarettes induce DNA damage and inhibit DNA repair in mice and human cells

      - May 25, 2018

    See companion article:

    • Tobacco smoking, E-cigarettes, and nicotine harm

      - Jan 31, 2018
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    Disruption of the anaphase-promoting complex confers resistance to TTK inhibitors in triple-negative breast cancer

    K. L. Thu, J. Silvester, M. J. Elliott, W. Ba-alawi, M. H. Duncan, A. C. Elia, A. S. Mer, P. Smirnov, Z. Safikhani, B. Haibe-Kains, T. W. Mak, and D. W. Cescon

    PNAS February 13, 2018 115 (7) E1570-E1577; first published January 29, 2018. https://doi.org/10.1073/pnas.1719577115
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    In vivo wireless photonic photodynamic therapy

    Akshaya Bansal, Fengyuan Yang, Tian Xi, Yong Zhang, and John S. Ho

    PNAS February 13, 2018 115 (7) 1469-1474; first published January 29, 2018. https://doi.org/10.1073/pnas.1717552115
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    Insecurity, polio vaccination rates, and polio incidence in northwest Pakistan

    Amol A. Verma, Marcia P. Jimenez, Rudolf H. Tangermann, S. V. Subramanian, and Fahad Razak

    PNAS February 13, 2018 115 (7) 1593-1598; first published January 29, 2018. https://doi.org/10.1073/pnas.1711923115

• Microbiology

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    Pyruvate cycle increases aminoglycoside efficacy and provides respiratory energy in bacteria

    Yu-bin Su, Bo Peng, Hui Li, Zhi-xue Cheng, Tian-tuo Zhang, Jia-xin Zhu, Dan Li, Min-yi Li, Jin-zhou Ye, Chao-chao Du, Song Zhang, Xian-liang Zhao, Man-jun Yang, and Xuan-xian Peng

    PNAS February 13, 2018 115 (7) E1578-E1587; first published January 30, 2018. https://doi.org/10.1073/pnas.1714645115

    See companion article:

    • Reply to Nikaido: The pyruvate cycle provides respiratory energy and potentiates aminoglycosides to kill multidrug-resistant bacteria

      - Jul 16, 2019
  • You have access

    Plasticity of Mycobacterium tuberculosis NADH dehydrogenases and their role in virulence

    Catherine Vilchèze, Brian Weinrick, Lawrence W. Leung, and William R. Jacobs Jr.

    PNAS February 13, 2018 115 (7) 1599-1604; first published January 30, 2018. https://doi.org/10.1073/pnas.1721545115
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    Adaptation of commensal proliferating Escherichia coli to the intestinal tract of young children with cystic fibrosis

    Susana Matamouros, Hillary S. Hayden, Kyle R. Hager, Mitchell J. Brittnacher, Kristina Lachance, Eli J. Weiss, Christopher E. Pope, Anne-Flore Imhaus, Colin P. McNally, Elhanan Borenstein, Lucas R. Hoffman, and Samuel I. Miller

    PNAS February 13, 2018 115 (7) 1605-1610; first published January 29, 2018. https://doi.org/10.1073/pnas.1714373115
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    Hippocampal expression of a virus-derived protein impairs memory in mice

    Alexandre Bétourné, Marion Szelechowski, Anne Thouard, Erika Abrial, Arnaud Jean, Falek Zaidi, Charlotte Foret, Emilie M. Bonnaud, Caroline M. Charlier, Elsa Suberbielle, Cécile E. Malnou, Sylvie Granon, Claire Rampon, and Daniel Gonzalez-Dunia

    PNAS February 13, 2018 115 (7) 1611-1616; first published January 29, 2018. https://doi.org/10.1073/pnas.1711977115

• Neuroscience

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    Wireless optoelectronic photometers for monitoring neuronal dynamics in the deep brain

    Luyao Lu, Philipp Gutruf, Li Xia, Dionnet L. Bhatti, Xinying Wang, Abraham Vazquez-Guardado, Xin Ning, Xinru Shen, Tian Sang, Rongxue Ma, Grace Pakeltis, Gabriel Sobczak, Hao Zhang, Dong-oh Seo, Mantian Xue, Lan Yin, Debashis Chanda, Xing Sheng, Michael R. Bruchas, and John A. Rogers

    PNAS February 13, 2018 115 (7) E1374-E1383; first published January 29, 2018. https://doi.org/10.1073/pnas.1718721115
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    Superior colliculus neuronal ensemble activity signals optimal rather than subjective confidence

    Brian Odegaard, Piercesare Grimaldi, Seong Hah Cho, Megan A. K. Peters, Hakwan Lau, and Michele A. Basso

    PNAS February 13, 2018 115 (7) E1588-E1597; first published January 30, 2018. https://doi.org/10.1073/pnas.1711628115
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    Heterogeneity within the frontoparietal control network and its relationship to the default and dorsal attention networks

    Matthew L. Dixon, Alejandro De La Vega, Caitlin Mills, Jessica Andrews-Hanna, R. Nathan Spreng, Michael W. Cole, and Kalina Christoff

    PNAS February 13, 2018 115 (7) E1598-E1607; first published January 30, 2018. https://doi.org/10.1073/pnas.1715766115
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    Effects of the ecto-ATPase apyrase on microglial ramification and surveillance reflect cell depolarization, not ATP depletion

    Christian Madry, I. Lorena Arancibia-Cárcamo, Vasiliki Kyrargyri, Victor T. T. Chan, Nicola B. Hamilton, and David Attwell

    PNAS February 13, 2018 115 (7) E1608-E1617; first published January 30, 2018. https://doi.org/10.1073/pnas.1715354115
  • Open Access

    Restoring GABAergic inhibition rescues memory deficits in a Huntington’s disease mouse model

    Zahra Dargaei, Jee Yoon Bang, Vivek Mahadevan, C. Sahara Khademullah, Simon Bedard, Gustavo Morrone Parfitt, Jun Chul Kim, and Melanie A. Woodin

    PNAS February 13, 2018 115 (7) E1618-E1626; first published January 30, 2018. https://doi.org/10.1073/pnas.1716871115
  • Open Access

    Entorhinal fast-spiking speed cells project to the hippocampus

    Jing Ye, Menno P. Witter, May-Britt Moser, and Edvard I. Moser

    PNAS February 13, 2018 115 (7) E1627-E1636; first published January 31, 2018. https://doi.org/10.1073/pnas.1720855115
  • Open Access

    Path integration in place cells of developing rats

    Tale L. Bjerknes, Nenitha C. Dagslott, Edvard I. Moser, and May-Britt Moser

    PNAS February 13, 2018 115 (7) E1637-E1646; first published January 30, 2018. https://doi.org/10.1073/pnas.1719054115
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    Brain-state dependent astrocytic Ca²⁺ signals are coupled to both positive and negative BOLD-fMRI signals

    Maosen Wang, Yi He, Terrence J. Sejnowski, and Xin Yu

    PNAS February 13, 2018 115 (7) E1647-E1656; first published January 30, 2018. https://doi.org/10.1073/pnas.1711692115
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    Myopic (HD-PTP, PTPN23) selectively regulates synaptic neuropeptide release

    Dinara Bulgari, Anupma Jha, David L. Deitcher, and Edwin S. Levitan

    PNAS February 13, 2018 115 (7) 1617-1622; first published January 29, 2018. https://doi.org/10.1073/pnas.1716801115
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    Neuronal control of astrocytic respiration through a variant of the Crabtree effect

    Ignacio Fernández-Moncada, Iván Ruminot, Daniel Robles-Maldonado, Karin Alegría, Joachim W. Deitmer, and L. Felipe Barros

    PNAS February 13, 2018 115 (7) 1623-1628; first published January 29, 2018. https://doi.org/10.1073/pnas.1716469115
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    DJ-1 deficiency impairs synaptic vesicle endocytosis and reavailability at nerve terminals

    Jae Won Kyung, Jin-Mo Kim, Wongyoung Lee, Tae-Young Ha, Seon-Heui Cha, Kyung-Hwun Chung, Dong-Joo Choi, Ilo Jou, Woo Keun Song, Eun-Hye Joe, Sung Hyun Kim, and Sang Myun Park

    PNAS February 13, 2018 115 (7) 1629-1634; first published January 31, 2018. https://doi.org/10.1073/pnas.1708754115
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    Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice

    Yulan Xiong, Stewart Neifert, Senthilkumar S. Karuppagounder, Qinfang Liu, Jeannette N. Stankowski, Byoung Dae Lee, Han Seok Ko, Yunjong Lee, Jonathan C. Grima, Xiaobo Mao, Haisong Jiang, Sung-Ung Kang, Deborah A. Swing, Lorraine Iacovitti, Lino Tessarollo, Ted M. Dawson, and Valina L. Dawson

    PNAS February 13, 2018 115 (7) 1635-1640; first published January 31, 2018. https://doi.org/10.1073/pnas.1712648115

• Pharmacology

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    TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain

    Miguel Ortíz-Rentería, Rebeca Juárez-Contreras, Ricardo González-Ramírez, León D. Islas, Félix Sierra-Ramírez, Itzel Llorente, Sidney A. Simon, Marcia Hiriart, Tamara Rosenbaum, and Sara L. Morales-Lázaro

    PNAS February 13, 2018 115 (7) E1657-E1666; first published January 29, 2018. https://doi.org/10.1073/pnas.1715972115

• Physiology

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    Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F

    Wenlei Ye, Tina W. Han, Layla M. Nassar, Mario Zubia, Yuh Nung Jan, and Lily Yeh Jan

    PNAS February 13, 2018 115 (7) E1667-E1674; first published January 30, 2018. https://doi.org/10.1073/pnas.1718728115
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    Evidence that asymmetry of the membrane/cytoskeletal complex in human red blood cell ghosts is responsible for their biconcave shape

    Joseph F. Hoffman

    PNAS February 13, 2018 115 (7) 1641-1645; first published January 30, 2018. https://doi.org/10.1073/pnas.1721463115
  • Open Access

    Centipedes subdue giant prey by blocking KCNQ channels

    Lei Luo, Bowen Li, Sheng Wang, Fangming Wu, Xiaochen Wang, Ping Liang, Rose Ombati, Junji Chen, Xiancui Lu, Jianmin Cui, Qiumin Lu, Longhua Zhang, Ming Zhou, Changlin Tian, Shilong Yang, and Ren Lai

    PNAS February 13, 2018 115 (7) 1646-1651; first published January 22, 2018. https://doi.org/10.1073/pnas.1714760115

• Plant Biology

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    AtCAP2 is crucial for lytic vacuole biogenesis during germination by positively regulating vacuolar protein trafficking

    Yun Kwon, Jinbo Shen, Myoung Hui Lee, Kyoung Rok Geem, Liwen Jiang, and Inhwan Hwang

    PNAS February 13, 2018 115 (7) E1675-E1683; first published January 29, 2018. https://doi.org/10.1073/pnas.1717204115
  • You have access

    Endoplasmic reticulum acyltransferase with prokaryotic substrate preference contributes to triacylglycerol assembly in Chlamydomonas

    Yeongho Kim, Ee Leng Terng, Wayne R. Riekhof, Edgar B. Cahoon, and Heriberto Cerutti

    PNAS February 13, 2018 115 (7) 1652-1657; first published January 30, 2018. https://doi.org/10.1073/pnas.1715922115

• Psychological and Cognitive Sciences

  • Open Access

    Projecting one’s own spatial bias onto others during a theory-of-mind task

    • From the Cover

    Branden J. Bio, Taylor W. Webb, and Michael S. A. Graziano

    PNAS February 13, 2018 115 (7) E1684-E1689; first published January 16, 2018. https://doi.org/10.1073/pnas.1718493115

    See companion article:

    • Conceptualizing degrees of theory of mind

      - Jan 31, 2018
  • Open Access

    Stimulus generalization as a mechanism for learning to trust

    Oriel FeldmanHall, Joseph E. Dunsmoor, Alexa Tompary, Lindsay E. Hunter, Alexander Todorov, and Elizabeth A. Phelps

    PNAS February 13, 2018 115 (7) E1690-E1697; first published January 29, 2018. https://doi.org/10.1073/pnas.1715227115
  • You have access

    Child first language and adult second language are both tied to general-purpose learning systems

    Phillip Hamrick, Jarrad A. G. Lum, and Michael T. Ullman

    PNAS February 13, 2018 115 (7) 1487-1492; first published January 29, 2018. https://doi.org/10.1073/pnas.1713975115

• Sustainability Science

  • Open Access

    Economic value of ecological information in ecosystem-based natural resource management depends on exploitation history

    Timothy E. Essington, James N. Sanchirico, and Marissa L. Baskett

    PNAS February 13, 2018 115 (7) 1658-1663; first published January 29, 2018. https://doi.org/10.1073/pnas.1716858115

• Systems Biology

  • Open Access

    Automated monitoring of behavior reveals bursty interaction patterns and rapid spreading dynamics in honeybee social networks

    Tim Gernat, Vikyath D. Rao, Martin Middendorf, Harry Dankowicz, Nigel Goldenfeld, and Gene E. Robinson

    PNAS February 13, 2018 115 (7) 1433-1438; first published January 29, 2018. https://doi.org/10.1073/pnas.1713568115