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Research Article

E-cigarette smoke damages DNA and reduces repair activity in mouse lung, heart, and bladder as well as in human lung and bladder cells

Hyun-Wook Lee, Sung-Hyun Park, Mao-wen Weng, Hsiang-Tsui Wang, William C. Huang, Herbert Lepor, Xue-Ru Wu, Lung-Chi Chen, and Moon-shong Tang
PNAS February 13, 2018 115 (7) E1560-E1569; first published January 29, 2018; https://doi.org/10.1073/pnas.1718185115
Hyun-Wook Lee
aDepartment of Environmental Medicine, New York University School of Medicine, Tuxedo Park, NY 10987;
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Sung-Hyun Park
aDepartment of Environmental Medicine, New York University School of Medicine, Tuxedo Park, NY 10987;
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Mao-wen Weng
aDepartment of Environmental Medicine, New York University School of Medicine, Tuxedo Park, NY 10987;
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Hsiang-Tsui Wang
aDepartment of Environmental Medicine, New York University School of Medicine, Tuxedo Park, NY 10987;
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William C. Huang
bDepartment of Urology, New York University School of Medicine, New York, NY 10016
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Herbert Lepor
bDepartment of Urology, New York University School of Medicine, New York, NY 10016
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Xue-Ru Wu
bDepartment of Urology, New York University School of Medicine, New York, NY 10016
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Lung-Chi Chen
aDepartment of Environmental Medicine, New York University School of Medicine, Tuxedo Park, NY 10987;
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Moon-shong Tang
aDepartment of Environmental Medicine, New York University School of Medicine, Tuxedo Park, NY 10987;
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  • For correspondence: moon-shong.tang@nyumc.org
  1. Edited by Bert Vogelstein, Johns Hopkins University, Baltimore, MD, and approved December 20, 2017 (received for review October 17, 2017)

This article has Letters. Please see:

  • Assessment of E-cigarette impact on smokers: The importance of experimental conditions relevant to human consumption - March 13, 2018
  • Electronic cigarette aerosols induce DNA damage and reduce DNA repair: Consistency across species - May 25, 2018

See related content:

  • Reply to Li Volti et al.: E-cigarette smoke exposure and effect in mice and human cells
    - Mar 13, 2018
  • Reply to Queimado et al.: E-cigarettes induce DNA damage and inhibit DNA repair in mice and human cells
    - May 25, 2018

See related content:

  • Tobacco smoking, E-cigarettes, and nicotine harm
    - Jan 31, 2018
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Article Information

vol. 115 no. 7 E1560-E1569
DOI: 
https://doi.org/10.1073/pnas.1718185115
PubMed: 
29378943

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue February 13, 2018.
  • Published first January 29, 2018.

Article Versions

  • Previous version (January 29, 2018 - 11:50).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
Copyright © 2018 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

Author Information

  1. Hyun-Wook Leea,1,
  2. Sung-Hyun Parka,1,
  3. Mao-wen Wenga,1,
  4. Hsiang-Tsui Wanga,
  5. William C. Huangb,
  6. Herbert Leporb,
  7. Xue-Ru Wub,
  8. Lung-Chi Chena, and
  9. Moon-shong Tanga,2
  1. aDepartment of Environmental Medicine, New York University School of Medicine, Tuxedo Park, NY 10987;
  2. bDepartment of Urology, New York University School of Medicine, New York, NY 10016
  1. Edited by Bert Vogelstein, Johns Hopkins University, Baltimore, MD, and approved December 20, 2017 (received for review October 17, 2017)

Footnotes

  • ↵1H.-W. L., S.-H. P., and M.-w.W. contributed equally to this work.

  • ↵2To whom correspondence should be addressed. Email: moon-shong.tang{at}nyumc.org.
  • Author contributions: H.-W.L., S.-H.P., M.-w.W., H.-T.W., L.-C.C., and M.-s.T. designed research; H.-W.L., S.-H.P., M.-w.W., H.-T.W., and M.-s.T. performed research; M.-s.T. contributed new reagents/analytic tools; H.-W.L., S.-H.P., M.-w.W., W.C.H., H.L., X.-R.W., and M.-s.T. analyzed data; and H.-W.L., S.-H.P., M.-w.W., H.-T.W., W.C.H., H.L., X.-R.W., L.-C.C., and M.-s.T. wrote the paper.

  • The authors declare no conflict of interest.

  • This article is a PNAS Direct Submission.

  • See Commentary on page 1406.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1718185115/-/DCSupplemental.

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Article usage

Article usage: January 2018 to February 2021

AbstractFullPdf
Jan 201837430370713020
Feb 201845074447993055
Mar 201885498523974
Apr 201845224514533
May 201843674327422
Jun 201838263837325
Jul 201828552844269
Aug 201841374108352
Sep 201832473246444
Oct 20183523543413
Nov 2018463095276
Dec 2018232230190
Total 201811442812213710273
Jan 2019283553249
Feb 2019422222226
Mar 2019512462201
Apr 2019792241164
May 20191191735165
Jun 2019261901156
Jul 2019281498207
Aug 2019322279155
Sep 2019602523183
Oct 20191443753480
Nov 20191241953212
Dec 2019692113153
Total 2019802282332551
Jan 2020501528137
Feb 2020671436141
Mar 2020801639239
Apr 2020991119172
May 2020701032131
Jun 20202161381
Jul 20202968472
Aug 202040735126
Sep 202058729112
Oct 202085865125
Nov 202078811156
Dec 202068818127
Total 2020745120091619
Jan 202144885121
Feb 202128618103
Total 2021721503224
Total11604716388214667
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E-cig damages DNA in lung, heart, and bladder
Hyun-Wook Lee, Sung-Hyun Park, Mao-wen Weng, Hsiang-Tsui Wang, William C. Huang, Herbert Lepor, Xue-Ru Wu, Lung-Chi Chen, Moon-shong Tang
Proceedings of the National Academy of Sciences Feb 2018, 115 (7) E1560-E1569; DOI: 10.1073/pnas.1718185115

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E-cig damages DNA in lung, heart, and bladder
Hyun-Wook Lee, Sung-Hyun Park, Mao-wen Weng, Hsiang-Tsui Wang, William C. Huang, Herbert Lepor, Xue-Ru Wu, Lung-Chi Chen, Moon-shong Tang
Proceedings of the National Academy of Sciences Feb 2018, 115 (7) E1560-E1569; DOI: 10.1073/pnas.1718185115
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