Table of Contents

Biological Sciences

• Agricultural Sciences

  • Open Access

    Crop variety management for climate adaptation supported by citizen science

    Jacob van Etten, Kauê de Sousa, Amílcar Aguilar, Mirna Barrios, Allan Coto, Matteo Dell’Acqua, Carlo Fadda, Yosef Gebrehawaryat, Jeske van de Gevel, Arnab Gupta, Afewerki Y. Kiros, Brandon Madriz, Prem Mathur, Dejene K. Mengistu, Leida Mercado, Jemal Nurhisen Mohammed, Ambica Paliwal, Mario Enrico Pè, Carlos F. Quirós, Juan Carlos Rosas, Neeraj Sharma, S. S. Singh, Iswhar S. Solanki, and Jonathan Steinke

    PNAS March 5, 2019 116 (10) 4194-4199; first published February 19, 2019. https://doi.org/10.1073/pnas.1813720116

• Applied Biological Sciences

  • You have access

    Egg-based influenza split virus vaccine with monoglycosylation induces cross-strain protection against influenza virus infections

    Yung-Chieh Tseng, Chia-Yu Wu, Ming-Liang Liu, Ting-Hua Chen, Wan-Ling Chiang, Yueh-Hsiang Yu, Jia-Tsrong Jan, Kuo-I Lin, Chi-Huey Wong, and Che Ma

    PNAS March 5, 2019 116 (10) 4200-4205; first published February 19, 2019. https://doi.org/10.1073/pnas.1819197116

• Biochemistry

  • You have access

    The structure of the catalytic domain of the ATP synthase from Mycobacterium smegmatis is a target for developing antitubercular drugs

    • From the Cover

    Alice Tianbu Zhang, Martin G. Montgomery, Andrew G. W. Leslie, Gregory M. Cook, and John E. Walker

    PNAS March 5, 2019 116 (10) 4206-4211; first published January 25, 2019. https://doi.org/10.1073/pnas.1817615116

    See companion article:

    • Turbine enzyme’s structure in the crosshairs to target tuberculosis

      - Feb 19, 2019
  • You have access

    LHCSR3 is a nonphotochemical quencher of both photosystems in Chlamydomonas reinhardtii

    Laura Girolomoni, Stefano Cazzaniga, Alberta Pinnola, Federico Perozeni, Matteo Ballottari, and Roberto Bassi

    PNAS March 5, 2019 116 (10) 4212-4217; first published February 19, 2019. https://doi.org/10.1073/pnas.1809812116
  • You have access

    Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation

    Brian Tsang, Jason Arsenault, Robert M. Vernon, Hong Lin, Nahum Sonenberg, Lu-Yang Wang, Alaji Bah, and Julie D. Forman-Kay

    PNAS March 5, 2019 116 (10) 4218-4227; first published February 14, 2019. https://doi.org/10.1073/pnas.1814385116
  • You have access

    26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation

    Jordan J. S. VerPlank, Sudarsanareddy Lokireddy, Jinghui Zhao, and Alfred L. Goldberg

    PNAS March 5, 2019 116 (10) 4228-4237; first published February 19, 2019. https://doi.org/10.1073/pnas.1809254116

• Biophysics and Computational Biology

  • You have access

    Structural basis for activity of TRIC counter-ion channels in calcium release

    Xiao-hui Wang, Min Su, Feng Gao, Wenjun Xie, Yang Zeng, De-lin Li, Xue-lei Liu, Hong Zhao, Li Qin, Fei Li, Qun Liu, Oliver B. Clarke, Sin Man Lam, Guang-hou Shui, Wayne A. Hendrickson, and Yu-hang Chen

    PNAS March 5, 2019 116 (10) 4238-4243; first published February 15, 2019. https://doi.org/10.1073/pnas.1817271116
  • Open Access

    Atomic-level characterization of protein–protein association

    Albert C. Pan, Daniel Jacobson, Konstantin Yatsenko, Duluxan Sritharan, Thomas M. Weinreich, and David E. Shaw

    PNAS March 5, 2019 116 (10) 4244-4249; first published February 13, 2019. https://doi.org/10.1073/pnas.1815431116
  • Open Access

    Dimers of mitochondrial ATP synthase induce membrane curvature and self-assemble into rows

    Thorsten B. Blum, Alexander Hahn, Thomas Meier, Karen M. Davies, and Werner Kühlbrandt

    PNAS March 5, 2019 116 (10) 4250-4255; first published February 13, 2019. https://doi.org/10.1073/pnas.1816556116
  • You have access

    Assembly and cryo-EM structures of RNA-specific measles virus nucleocapsids provide mechanistic insight into paramyxoviral replication

    Ambroise Desfosses, Sigrid Milles, Malene Ringkjøbing Jensen, Serafima Guseva, Jacques-Philippe Colletier, Damien Maurin, Guy Schoehn, Irina Gutsche, Rob W. H. Ruigrok, and Martin Blackledge

    PNAS March 5, 2019 116 (10) 4256-4264; first published February 20, 2019. https://doi.org/10.1073/pnas.1816417116
  • You have access

    Mechanism of actin polymerization revealed by cryo-EM structures of actin filaments with three different bound nucleotides

    Steven Z. Chou and Thomas D. Pollard

    PNAS March 5, 2019 116 (10) 4265-4274; first published February 13, 2019. https://doi.org/10.1073/pnas.1807028115

    See companion article:

    • Nucleotide-dependent conformational changes in the actin filament: Subtler than expected

      - Feb 19, 2019
  • Open Access

    Nanometer-accuracy distance measurements between fluorophores at the single-molecule level

    Stefan Niekamp, Jongmin Sung, Walter Huynh, Gira Bhabha, Ronald D. Vale, and Nico Stuurman

    PNAS March 5, 2019 116 (10) 4275-4284; first published February 15, 2019. https://doi.org/10.1073/pnas.1815826116

• Cell Biology

  • You have access

    Biosynthesis of magnetic nanoparticles from nano-degradation products revealed in human stem cells

    Aurore Van de Walle, Anouchka Plan Sangnier, Ali Abou-Hassan, Alberto Curcio, Miryana Hémadi, Nicolas Menguy, Yoann Lalatonne, Nathalie Luciani, and Claire Wilhelm

    PNAS March 5, 2019 116 (10) 4044-4053; first published February 13, 2019. https://doi.org/10.1073/pnas.1816792116
  • Open Access

    PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin

    Aurèle Besse-Patin, Stewart Jeromson, Philipa Levesque-Damphousse, Blandine Secco, Mathieu Laplante, and Jennifer L. Estall

    PNAS March 5, 2019 116 (10) 4285-4290; first published February 15, 2019. https://doi.org/10.1073/pnas.1815150116
  • Open Access

    Tissue self-organization based on collective cell migration by contact activation of locomotion and chemotaxis

    Taihei Fujimori, Akihiko Nakajima, Nao Shimada, and Satoshi Sawai

    PNAS March 5, 2019 116 (10) 4291-4296; first published February 19, 2019. https://doi.org/10.1073/pnas.1815063116
  • Open Access

    A mechanism for temporary bioadhesion

    Julia Wunderer, Birgit Lengerer, Robert Pjeta, Philip Bertemes, Leopold Kremser, Herbert Lindner, Thomas Ederth, Michael W. Hess, David Stock, Willi Salvenmoser, and Peter Ladurner

    PNAS March 5, 2019 116 (10) 4297-4306; first published February 19, 2019. https://doi.org/10.1073/pnas.1814230116
  • You have access

    Concentric organization of A- and B-type lamins predicts their distinct roles in the spatial organization and stability of the nuclear lamina

    Bruce Nmezi, Jianquan Xu, Rao Fu, Travis J. Armiger, Guillermo Rodriguez-Bey, Juliana S. Powell, Hongqiang Ma, Mara Sullivan, Yiping Tu, Natalie Y. Chen, Stephen G. Young, Donna B. Stolz, Kris Noel Dahl, Yang Liu, and Quasar S. Padiath

    PNAS March 5, 2019 116 (10) 4307-4315; first published February 14, 2019. https://doi.org/10.1073/pnas.1810070116
  • Open Access

    Fibroblast growth factor receptor influences primary cilium length through an interaction with intestinal cell kinase

    Michaela Kunova Bosakova, Alexandru Nita, Tomas Gregor, Miroslav Varecha, Iva Gudernova, Bohumil Fafilek, Tomas Barta, Neha Basheer, Sara P. Abraham, Lukas Balek, Marketa Tomanova, Jana Fialova Kucerova, Juraj Bosak, David Potesil, Jennifer Zieba, Jieun Song, Peter Konik, Sohyun Park, Ivan Duran, Zbynek Zdrahal, David Smajs, Gert Jansen, Zheng Fu, Hyuk Wan Ko, Ales Hampl, Lukas Trantirek, Deborah Krakow, and Pavel Krejci

    PNAS March 5, 2019 116 (10) 4316-4325; first published February 19, 2019. https://doi.org/10.1073/pnas.1800338116
  • You have access

    Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1

    Cecilia Roux, Soode Moghadas Jafari, Rahul Shinde, Gordon Duncan, David W. Cescon, Jennifer Silvester, Mandy F. Chu, Kelsey Hodgson, Thorsten Berger, Andrew Wakeham, Luis Palomero, Mar Garcia-Valero, Miguel A. Pujana, Tak W. Mak, Tracy L. McGaha, Paola Cappello, and Chiara Gorrini

    PNAS March 5, 2019 116 (10) 4326-4335; first published February 15, 2019. https://doi.org/10.1073/pnas.1819473116
  • Open Access

    Early onset preeclampsia in a model for human placental trophoblast

    Megan A. Sheridan, Ying Yang, Ashish Jain, Alex S. Lyons, Penghua Yang, Sambasiva R. Brahmasani, Aihua Dai, Yuchen Tian, Mark R. Ellersieck, Geetu Tuteja, Danny J. Schust, Laura C. Schulz, Toshihiko Ezashi, and R. Michael Roberts

    PNAS March 5, 2019 116 (10) 4336-4345; first published February 20, 2019. https://doi.org/10.1073/pnas.1816150116

• Developmental Biology

  • You have access

    Pluripotent stem cell-derived myogenic progenitors remodel their molecular signature upon in vivo engraftment

    Tania Incitti, Alessandro Magli, Radbod Darabi, Ce Yuan, Karena Lin, Robert W. Arpke, Karim Azzag, Ami Yamamoto, Ron Stewart, James A. Thomson, Michael Kyba, and Rita C. R. Perlingeiro

    PNAS March 5, 2019 116 (10) 4346-4351; first published February 13, 2019. https://doi.org/10.1073/pnas.1808303116
  • Open Access

    Coupling between dynamic 3D tissue architecture and BMP morphogen signaling during Drosophila wing morphogenesis

    Jinghua Gui, Yunxian Huang, Martin Montanari, Daniel Toddie-Moore, Kenji Kikushima, Stephanie Nix, Yukitaka Ishimoto, and Osamu Shimmi

    PNAS March 5, 2019 116 (10) 4352-4361; first published February 13, 2019. https://doi.org/10.1073/pnas.1815427116
  • You have access

    Early lineage specification defines alveolar epithelial ontogeny in the murine lung

    David B. Frank, Ian J. Penkala, Jarod A. Zepp, Aravind Sivakumar, Ricardo Linares-Saldana, William J. Zacharias, Katharine G. Stolz, Josh Pankin, MinQi Lu, Qiaohong Wang, Apoorva Babu, Li Li, Su Zhou, Michael P. Morley, Rajan Jain, and Edward E. Morrisey

    PNAS March 5, 2019 116 (10) 4362-4371; first published February 19, 2019. https://doi.org/10.1073/pnas.1813952116

• Ecology

  • Open Access

    Experimental support for alternative attractors on coral reefs

    • From the Cover

    Russell J. Schmitt, Sally J. Holbrook, Samantha L. Davis, Andrew J. Brooks, and Thomas C. Adam

    PNAS March 5, 2019 116 (10) 4372-4381; first published February 11, 2019. https://doi.org/10.1073/pnas.1812412116

• Environmental Sciences

  • You have access

    Role of forest regrowth in global carbon sink dynamics

    • From the Cover

    Thomas A. M. Pugh, Mats Lindeskog, Benjamin Smith, Benjamin Poulter, Almut Arneth, Vanessa Haverd, and Leonardo Calle

    PNAS March 5, 2019 116 (10) 4382-4387; first published February 19, 2019. https://doi.org/10.1073/pnas.1810512116

    See companion article:

    • Forest age improves understanding of the global carbon sink

      - Feb 19, 2019
  • You have access

    Photosynthetic adaptation to low iron, light, and temperature in Southern Ocean phytoplankton

    Robert F. Strzepek, Philip W. Boyd, and William G. Sunda

    PNAS March 5, 2019 116 (10) 4388-4393; first published February 20, 2019. https://doi.org/10.1073/pnas.1810886116

• Evolution

  • You have access

    Trilobite evolutionary rates constrain the duration of the Cambrian explosion

    John R. Paterson, Gregory D. Edgecombe, and Michael S. Y. Lee

    PNAS March 5, 2019 116 (10) 4394-4399; first published February 19, 2019. https://doi.org/10.1073/pnas.1819366116
  • Open Access

    Molecular mechanism and history of non-sense to sense evolution of antifreeze glycoprotein gene in northern gadids

    Xuan Zhuang, Chun Yang, Katherine R. Murphy, and C.-H. Christina Cheng

    PNAS March 5, 2019 116 (10) 4400-4405; first published February 14, 2019. https://doi.org/10.1073/pnas.1817138116
  • You have access

    Extreme diversification of floral volatiles within and among species of Lithophragma (Saxifragaceae)

    Magne Friberg, Christopher Schwind, Paulo R. Guimarães Jr., Robert A. Raguso, and John N. Thompson

    PNAS March 5, 2019 116 (10) 4406-4415; first published February 14, 2019. https://doi.org/10.1073/pnas.1809007116
  • Open Access

    Lateral transfers of large DNA fragments spread functional genes among grasses

    Luke T. Dunning, Jill K. Olofsson, Christian Parisod, Rimjhim Roy Choudhury, Jose J. Moreno-Villena, Yang Yang, Jacqueline Dionora, W. Paul Quick, Minkyu Park, Jeffrey L. Bennetzen, Guillaume Besnard, Patrik Nosil, Colin P. Osborne, and Pascal-Antoine Christin

    PNAS March 5, 2019 116 (10) 4416-4425; first published February 20, 2019. https://doi.org/10.1073/pnas.1810031116
  • Open Access

    Evolution of resilience in protein interactomes across the tree of life

    Marinka Zitnik, Rok Sosič, Marcus W. Feldman, and Jure Leskovec

    PNAS March 5, 2019 116 (10) 4426-4433; first published February 14, 2019. https://doi.org/10.1073/pnas.1818013116

• Genetics

  • You have access

    Self-regulation and the foraging gene (PRKG1) in humans

    Andriy A. Struk, Jhotisha Mugon, Andrea Huston, Abigail A. Scholer, Gertraud Stadler, E. Tory Higgins, Marla B. Sokolowski, and James Danckert

    PNAS March 5, 2019 116 (10) 4434-4439; first published February 19, 2019. https://doi.org/10.1073/pnas.1809924116

    See companion article:

    • Reply to Lyon et al.: Self-regulation and the foraging gene: From flies to humans

      - Jul 23, 2019
  • You have access

    Processing generates 3′ ends of RNA masking transcription termination events in prokaryotes

    Xun Wang, Monford Paul Abishek N, Heung Jin Jeon, Yonho Lee, Jin He, Sankar Adhya, and Heon M. Lim

    PNAS March 5, 2019 116 (10) 4440-4445; first published February 19, 2019. https://doi.org/10.1073/pnas.1813181116
  • You have access

    White shark genome reveals ancient elasmobranch adaptations associated with wound healing and the maintenance of genome stability

    Nicholas J. Marra, Michael J. Stanhope, Nathaniel K. Jue, Minghui Wang, Qi Sun, Paulina Pavinski Bitar, Vincent P. Richards, Aleksey Komissarov, Mike Rayko, Sergey Kliver, Bryce J. Stanhope, Chuck Winkler, Stephen J. O’Brien, Agostinho Antunes, Salvador Jorgensen, and Mahmood S. Shivji

    PNAS March 5, 2019 116 (10) 4446-4455; first published February 19, 2019. https://doi.org/10.1073/pnas.1819778116

• Immunology and Inflammation

  • You have access

    Fate mapping reveals the age structure of the peripheral T cell compartment

    Arnold Reynaldi, Norah L. Smith, Timothy E. Schlub, Cybelle Tabilas, Vanessa Venturi, Brian D. Rudd, and Miles P. Davenport

    PNAS March 5, 2019 116 (10) 3974-3981; first published February 14, 2019. https://doi.org/10.1073/pnas.1811634116
  • You have access

    Role for nuclear interleukin-37 in the suppression of innate immunity

    Suzhao Li, Jesus Amo-Aparicio, Charles P. Neff, Isak W. Tengesdal, Tania Azam, Brent E. Palmer, Rubèn López-Vales, Philip Bufler, and Charles A. Dinarello

    PNAS March 5, 2019 116 (10) 4456-4461; first published February 21, 2019. https://doi.org/10.1073/pnas.1821111116
  • You have access

    Pivotal role for α_V integrins in sustained Tfh support of the germinal center response for long-lived plasma cell generation

    Dillon C. Schrock, Scott A. Leddon, Angela Hughson, Jim Miller, Adam Lacy-Hulbert, and Deborah J. Fowell

    PNAS March 5, 2019 116 (10) 4462-4470; first published February 15, 2019. https://doi.org/10.1073/pnas.1809329116
  • You have access

    E-protein regulatory network links TCR signaling to effector Treg cell differentiation

    Xiaojuan Han, Huarong Huang, Ping Gao, Qi Zhang, Xinyuan Liu, Baoqian Jia, Warren Strober, Baidong Hou, Xuyu Zhou, George Fu Gao, and Fuping Zhang

    PNAS March 5, 2019 116 (10) 4471-4480; first published February 15, 2019. https://doi.org/10.1073/pnas.1800494116
  • You have access

    CD4⁺ T help promotes influenza virus-specific CD8⁺ T cell memory by limiting metabolic dysfunction

    Jolie G. Cullen, Hayley A. McQuilten, Kylie M. Quinn, Moshe Olshansky, Brendan E. Russ, Alison Morey, Sanna Wei, Julia E. Prier, Nicole L. La Gruta, Peter C. Doherty, and Stephen J. Turner

    PNAS March 5, 2019 116 (10) 4481-4488; first published February 20, 2019. https://doi.org/10.1073/pnas.1808849116

• Medical Sciences

  • Open Access

    Mobile platform for rapid sub–picogram-per-milliliter, multiplexed, digital droplet detection of proteins

    Venkata Yelleswarapu, Joshua R. Buser, Margalit Haber, Jonathan Baron, Eshwar Inapuri, and David Issadore

    PNAS March 5, 2019 116 (10) 4489-4495; first published February 14, 2019. https://doi.org/10.1073/pnas.1814110116
  • Open Access

    Dual AAV-mediated gene therapy restores hearing in a DFNB9 mouse model

    Omar Akil, Frank Dyka, Charlotte Calvet, Alice Emptoz, Ghizlene Lahlou, Sylvie Nouaille, Jacques Boutet de Monvel, Jean-Pierre Hardelin, William W. Hauswirth, Paul Avan, Christine Petit, Saaid Safieddine, and Lawrence R. Lustig

    PNAS March 5, 2019 116 (10) 4496-4501; first published February 19, 2019. https://doi.org/10.1073/pnas.1817537116
  • You have access

    WNK4 kinase is a physiological intracellular chloride sensor

    Jen-Chi Chen, Yi-Fen Lo, Ya-Wen Lin, Shih-Hua Lin, Chou-Long Huang, and Chih-Jen Cheng

    PNAS March 5, 2019 116 (10) 4502-4507; first published February 14, 2019. https://doi.org/10.1073/pnas.1817220116

    See companion article:

    • Reply to Farfel et al.: Is enhanced chloride reabsorption in proximal tubule a possible mechanism of metabolic acidosis in PHAII?

      - Aug 01, 2019
  • You have access

    MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival

    Chih-Shia Lee, Liam C. Lee, Tina L. Yuan, Sirisha Chakka, Christof Fellmann, Scott W. Lowe, Natasha J. Caplen, Frank McCormick, and Ji Luo

    PNAS March 5, 2019 116 (10) 4508-4517; first published February 1, 2019. https://doi.org/10.1073/pnas.1817494116

    See companion article:

    • Blockade of RAF and autophagy is the one-two punch to take out Ras

      - Feb 19, 2019
  • You have access

    Podocalyxin is required for maintaining blood–brain barrier function during acute inflammation

    Jessica Cait, Michael R. Hughes, Matthew R. Zeglinski, Allen W. Chan, Sabrina Osterhof, R. Wilder Scott, Diana Canals Hernaez, Alissa Cait, A. Wayne Vogl, Pascal Bernatchez, T. Michael Underhill, David J. Granville, Timothy H. Murphy, Calvin D. Roskelley, and Kelly M. McNagny

    PNAS March 5, 2019 116 (10) 4518-4527; first published February 20, 2019. https://doi.org/10.1073/pnas.1814766116
  • Open Access

    Ovarian insufficiency and CTNNB1 mutations drive malignant transformation of endometrial hyperplasia with altered PTEN/PI3K activities

    Jumpei Terakawa, Vanida Ann Serna, Makoto Mark Taketo, Takiko Daikoku, Adrian A. Suarez, and Takeshi Kurita

    PNAS March 5, 2019 116 (10) 4528-4537; first published February 19, 2019. https://doi.org/10.1073/pnas.1814506116
  • You have access

    NOTCH1 signaling induces pathological vascular permeability in diabetic retinopathy

    Khalil Miloudi, Malika Oubaha, Catherine Ménard, Agnieszka Dejda, Vera Guber, Gael Cagnone, Ariel M. Wilson, Nicolas Tétreault, Gaëlle Mawambo, Francois Binet, Rony Chidiac, Chantal Delisle, Manuel Buscarlet, Agustin Cerani, Sergio Crespo-Garcia, Katie Bentley, Flavio Rezende, Jean-Sebastien Joyal, Frédérick A. Mallette, Jean-Philippe Gratton, Bruno Larrivée, and Przemyslaw Sapieha

    PNAS March 5, 2019 116 (10) 4538-4547; first published February 20, 2019. https://doi.org/10.1073/pnas.1814711116
  • Open Access

    Down-regulation of FZD3 receptor suppresses growth and metastasis of human melanoma independently of canonical WNT signaling

    Chen Li, Vincent Nguyen, Kaitlyn N. Clark, Tara Zahed, Shawn Sharkas, Fabian V. Filipp, and Alexander D. Boiko

    PNAS March 5, 2019 116 (10) 4548-4557; first published February 21, 2019. https://doi.org/10.1073/pnas.1813802116
  • You have access

    Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer

    • From the Cover

    Ivy X. Chen, Vikash P. Chauhan, Jessica Posada, Mei R. Ng, Michelle W. Wu, Pichet Adstamongkonkul, Peigen Huang, Neal Lindeman, Robert Langer, and Rakesh K. Jain

    PNAS March 5, 2019 116 (10) 4558-4566; first published January 30, 2019. https://doi.org/10.1073/pnas.1815515116

    See companion article:

    • Targeting CXCR4-induced desmoplasia to improve checkpoint inhibition in breast cancer

      - Feb 22, 2019
  • You have access

    Mouse and human urothelial cancer organoids: A tool for bladder cancer research

    Jasper Mullenders, Evelien de Jongh, Anneta Brousali, Mieke Roosen, Jan P. A. Blom, Harry Begthel, Jeroen Korving, Trudy Jonges, Onno Kranenburg, Richard Meijer, and Hans C. Clevers

    PNAS March 5, 2019 116 (10) 4567-4574; first published February 20, 2019. https://doi.org/10.1073/pnas.1803595116
  • You have access

    Depletion of regulatory T cells in tumors with an anti-CD25 immunotoxin induces CD8 T cell-mediated systemic antitumor immunity

    Masanori Onda, Kazuto Kobayashi, and Ira Pastan

    PNAS March 5, 2019 116 (10) 4575-4582; first published February 13, 2019. https://doi.org/10.1073/pnas.1820388116
  • You have access

    Loss of BOP1 confers resistance to BRAF kinase inhibitors in melanoma by activating MAP kinase pathway

    Romi Gupta, Suresh Bugide, Biao Wang, Michael R. Green, Douglas B. Johnson, and Narendra Wajapeyee

    PNAS March 5, 2019 116 (10) 4583-4591; first published February 19, 2019. https://doi.org/10.1073/pnas.1821889116
  • You have access

    Anti-BCMA immunotoxins produce durable complete remissions in two mouse myeloma models

    Zoë Shancer, Xiu-fen Liu, Satoshi Nagata, Qi Zhou, Tapan K. Bera, and Ira Pastan

    PNAS March 5, 2019 116 (10) 4592-4598; first published February 19, 2019. https://doi.org/10.1073/pnas.1821733116

• Microbiology

  • You have access

    Vibrio cholerae FeoB contains a dual nucleotide-specific NTPase domain essential for ferrous iron uptake

    Minhye Shin, Alexandra R. Mey, and Shelley M. Payne

    PNAS March 5, 2019 116 (10) 4599-4604; first published February 13, 2019. https://doi.org/10.1073/pnas.1817964116
  • You have access

    A bacteria-based genetic assay detects prion formation

    Eleanor Fleming, Andy H. Yuan, Danielle M. Heller, and Ann Hochschild

    PNAS March 5, 2019 116 (10) 4605-4610; first published February 19, 2019. https://doi.org/10.1073/pnas.1817711116
  • Open Access

    H5N8 and H7N9 packaging signals constrain HA reassortment with a seasonal H3N2 influenza A virus

    Maria C. White, Hui Tao, John Steel, and Anice C. Lowen

    PNAS March 5, 2019 116 (10) 4611-4618; first published February 13, 2019. https://doi.org/10.1073/pnas.1818494116

• Neuroscience

  • You have access

    The nature of recollection across months and years and after medial temporal lobe damage

    Nadine C. Heyworth and Larry R. Squire

    PNAS March 5, 2019 116 (10) 4619-4624; first published February 21, 2019. https://doi.org/10.1073/pnas.1820765116
  • You have access

    Cortical route for facelike pattern processing in human newborns

    Marco Buiatti, Elisa Di Giorgio, Manuela Piazza, Carlo Polloni, Giuseppe Menna, Fabrizio Taddei, Ermanno Baldo, and Giorgio Vallortigara

    PNAS March 5, 2019 116 (10) 4625-4630; first published February 12, 2019. https://doi.org/10.1073/pnas.1812419116
  • Open Access

    Altered neural odometry in the vertical dimension

    Giulio Casali, Daniel Bush, and Kate Jeffery

    PNAS March 5, 2019 116 (10) 4631-4636; first published February 15, 2019. https://doi.org/10.1073/pnas.1811867116
  • You have access

    Priming of microglia with IFN-γ slows neuronal gamma oscillations in situ

    Thuy-Truc Ta, Hasan Onur Dikmen, Simone Schilling, Bruno Chausse, Andrea Lewen, Jan-Oliver Hollnagel, and Oliver Kann

    PNAS March 5, 2019 116 (10) 4637-4642; first published February 19, 2019. https://doi.org/10.1073/pnas.1813562116
  • Open Access

    Role of UCHL1 in axonal injury and functional recovery after cerebral ischemia

    Hao Liu, Nadya Povysheva, Marie E. Rose, Zhiping Mi, Joseph S. Banton, Wenjin Li, Fenghua Chen, Daniel P. Reay, Germán Barrionuevo, Feng Zhang, and Steven H. Graham

    PNAS March 5, 2019 116 (10) 4643-4650; first published February 13, 2019. https://doi.org/10.1073/pnas.1821282116
  • Open Access

    Six6 and Six7 coordinately regulate expression of middle-wavelength opsins in zebrafish

    Yohey Ogawa, Tomoya Shiraki, Yoshimasa Asano, Akira Muto, Koichi Kawakami, Yutaka Suzuki, Daisuke Kojima, and Yoshitaka Fukada

    PNAS March 5, 2019 116 (10) 4651-4660; first published February 14, 2019. https://doi.org/10.1073/pnas.1812884116
  • You have access

    Opposite regulation of Wnt/β-catenin and Shh signaling pathways by Rack1 controls mammalian cerebellar development

    Haihong Yang, Qian Zhu, Juanxian Cheng, Yan Wu, Ming Fan, Jiyan Zhang, and Haitao Wu

    PNAS March 5, 2019 116 (10) 4661-4670; first published February 14, 2019. https://doi.org/10.1073/pnas.1813244116
  • Open Access

    Role of the striatum in incidental learning of sound categories

    Sung-Joo Lim, Julie A. Fiez, and Lori L. Holt

    PNAS March 5, 2019 116 (10) 4671-4680; first published February 19, 2019. https://doi.org/10.1073/pnas.1811992116
  • Open Access

    Differential cortical microstructural maturation in the preterm human brain with diffusion kurtosis and tensor imaging

    Minhui Ouyang, Tina Jeon, Aristeidis Sotiras, Qinmu Peng, Virendra Mishra, Cathy Halovanic, Min Chen, Lina Chalak, Nancy Rollins, Timothy P. L. Roberts, Christos Davatzikos, and Hao Huang

    PNAS March 5, 2019 116 (10) 4681-4688; first published February 19, 2019. https://doi.org/10.1073/pnas.1812156116
  • You have access

    Multimodal gradients across mouse cortex

    Ben D. Fulcher, John D. Murray, Valerio Zerbi, and Xiao-Jing Wang

    PNAS March 5, 2019 116 (10) 4689-4695; first published February 19, 2019. https://doi.org/10.1073/pnas.1814144116
  • You have access

    Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects

    Joy Mitra, Erika N. Guerrero, Pavana M. Hegde, Nicole F. Liachko, Haibo Wang, Velmarini Vasquez, Junling Gao, Arvind Pandey, J. Paul Taylor, Brian C. Kraemer, Ping Wu, Istvan Boldogh, Ralph M. Garruto, Sankar Mitra, K. S. Rao, and Muralidhar L. Hegde

    PNAS March 5, 2019 116 (10) 4696-4705; first published February 15, 2019. https://doi.org/10.1073/pnas.1818415116

• Physiology

  • Open Access

    TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival

    Lorenz Mittermeier, Lusine Demirkhanyan, Benjamin Stadlbauer, Andreas Breit, Camilla Recordati, Anne Hilgendorff, Masayuki Matsushita, Attila Braun, David G. Simmons, Eleonora Zakharian, Thomas Gudermann, and Vladimir Chubanov

    PNAS March 5, 2019 116 (10) 4706-4715; first published February 15, 2019. https://doi.org/10.1073/pnas.1810633116

• Plant Biology

  • Open Access

    Mitochondrial small heat shock protein mediates seed germination via thermal sensing

    Wei Ma, Xueying Guan, Jie Li, Ronghui Pan, Luyao Wang, Fengjun Liu, Hongyu Ma, Shuijin Zhu, Jin Hu, Yong-Ling Ruan, Xiaoya Chen, and Tianzhen Zhang

    PNAS March 5, 2019 116 (10) 4716-4721; first published February 14, 2019. https://doi.org/10.1073/pnas.1815790116
  • You have access

    Two E3 ligases antagonistically regulate the UV-B response in Arabidopsis

    Hui Ren, Jiupan Han, Panyu Yang, Weiwei Mao, Xin Liu, Leilei Qiu, Chongzhen Qian, Yan Liu, Zhiren Chen, Xinhao Ouyang, Xu Chen, Xing Wang Deng, and Xi Huang

    PNAS March 5, 2019 116 (10) 4722-4731; first published February 20, 2019. https://doi.org/10.1073/pnas.1816268116

• Psychological and Cognitive Sciences

  • Open Access

    Social threat learning transfers to decision making in humans

    Björn Lindström, Armita Golkar, Simon Jangard, Philippe N. Tobler, and Andreas Olsson

    PNAS March 5, 2019 116 (10) 4732-4737; first published February 13, 2019. https://doi.org/10.1073/pnas.1810180116

• Systems Biology

  • Open Access

    The global mass and average rate of rubisco

    Yinon M. Bar-On and Ron Milo

    PNAS March 5, 2019 116 (10) 4738-4743; first published February 19, 2019. https://doi.org/10.1073/pnas.1816654116