Proceedings of the National Academy of Sciences: 116 (18)

New Research In

April 30, 2019; vol. 116 no. 18

This Week in PNAS

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In This Issue
PNAS April 30, 2019 116 (18) 8635-8637; https://doi.org/10.1073/iti1819116

Inner Workings

An over-the-shoulder look at scientists at work.

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Inner Workings: Genomics blazes a trail to improved cannabis cultivation
Front Matter
Elie Dolgin

PNAS April 30, 2019 116 (18) 8638-8640; https://doi.org/10.1073/pnas.1904094116

Profile

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Profile of Zhisheng An
Jennifer Viegas

PNAS April 30, 2019 116 (18) 8641-8643; first published April 15, 2019. https://doi.org/10.1073/pnas.1904581116
See companion article:
Severe haze in northern China: A synergy of anthropogenic emissions and atmospheric processes
- Apr 15, 2019

Commentaries

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Hyena politics: The dynamics of dynasties
Joan B. Silk

PNAS April 30, 2019 116 (18) 8644-8645; first published March 25, 2019. https://doi.org/10.1073/pnas.1903407116
See companion article:
Social alliances improve rank and fitness in convention-based societies
- Mar 11, 2019
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New age for progressive multiple sclerosis
Jaime Imitola

PNAS April 30, 2019 116 (18) 8646-8648; first published April 19, 2019. https://doi.org/10.1073/pnas.1903796116
See companion article:
Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis
- Mar 25, 2019

Letters

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Time domain versus energy domain neutron scattering analysis of protein dynamics
Wolfgang Doster

PNAS April 30, 2019 116 (18) 8649-8650; first published April 12, 2019. https://doi.org/10.1073/pnas.1821562116
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Reply to Doster: Franck–Condon and Van Hove formulation of quasielastic neutron scattering from complex systems
Gerald R. Kneller

PNAS April 30, 2019 116 (18) 8651-8652; first published April 12, 2019. https://doi.org/10.1073/pnas.1901851116
See companion article:
Franck–Condon picture of incoherent neutron scattering
- Aug 30, 2018
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Phototransduction gain at the G-protein, transducin, and effector protein, phosphodiesterase-6, stages in retinal rods
Martin Heck, Klaus Peter Hofmann, Timothy W. Kraft, and Trevor D. Lamb

PNAS April 30, 2019 116 (18) 8653-8654; first published April 30, 2019. https://doi.org/10.1073/pnas.1904017116
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Reply to Heck et al.: Signal amplification at the rhodopsin-to-transducin·phosphodiesterase step in rod phototransduction
K.-W. Yau, W. W. S. Yue, and D. Silverman

PNAS April 30, 2019 116 (18) 8655-8656; first published April 30, 2019. https://doi.org/10.1073/pnas.1904339116
See companion article:
Elementary response triggered by transducin in retinal rods
- Feb 22, 2019

Physical Sciences

Applied Physical Sciences
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  Deep learning in turbulent convection networks
  Enrico Fonda, Ambrish Pandey, Jörg Schumacher, and Katepalli R. Sreenivasan
  
  PNAS April 30, 2019 116 (18) 8667-8672; first published April 15, 2019. https://doi.org/10.1073/pnas.1900358116
- Open Access
  Scale-free resilience of real traffic jams
  Limiao Zhang, Guanwen Zeng, Daqing Li, Hai-Jun Huang, H. Eugene Stanley, and Shlomo Havlin
  
  PNAS April 30, 2019 116 (18) 8673-8678; first published April 12, 2019. https://doi.org/10.1073/pnas.1814982116
- Open Access
  Shock growth of ice crystal near equilibrium melting pressure under dynamic compression
  Yong-Jae Kim, Yun-Hee Lee, Sooheyong Lee, Hiroki Nada, and Geun Woo Lee
  
  PNAS April 30, 2019 116 (18) 8679-8684; first published April 15, 2019. https://doi.org/10.1073/pnas.1818122116
Biophysics and Computational Biology
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  A diecast mineralization process forms the tough mantis shrimp dactyl club
  Shahrouz Amini, Maryam Tadayon, Jun Jie Loke, Akshita Kumar, Deepankumar Kanagavel, Hortense Le Ferrand, Martial Duchamp, Manfred Raida, Radoslaw M. Sobota, Liyan Chen, Shawn Hoon, and Ali Miserez
  
  PNAS April 30, 2019 116 (18) 8685-8692; first published April 11, 2019. https://doi.org/10.1073/pnas.1816835116
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  Unified energetics analysis unravels SpCas9 cleavage activity for optimal gRNA design
  Dong Zhang, Travis Hurst, Dongsheng Duan, and Shi-Jie Chen
  
  PNAS April 30, 2019 116 (18) 8693-8698; first published April 15, 2019. https://doi.org/10.1073/pnas.1820523116
- Open Access
  Structural dynamics and transient lipid binding of synaptobrevin-2 tune SNARE assembly and membrane fusion
  Nils-Alexander Lakomek, Halenur Yavuz, Reinhard Jahn, and Ángel Pérez-Lara
  
  PNAS April 30, 2019 116 (18) 8699-8708; first published April 11, 2019. https://doi.org/10.1073/pnas.1813194116
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  Commonly used FRET fluorophores promote collapse of an otherwise disordered protein
  Joshua A. Riback, Micayla A. Bowman, Adam M. Zmyslowski, Kevin W. Plaxco, Patricia L. Clark, and Tobin R. Sosnick
  
  PNAS April 30, 2019 116 (18) 8889-8894; first published April 16, 2019. https://doi.org/10.1073/pnas.1813038116
Chemistry
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  Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1
  JuYeon Lee, Yugang Bai, Ullas V. Chembazhi, Shaohong Peng, Kevin Yum, Long M. Luu, Lauren D. Hagler, Julio F. Serrano, H. Y. Edwin Chan, Auinash Kalsotra, and Steven C. Zimmerman
  
  PNAS April 30, 2019 116 (18) 8709-8714; first published April 11, 2019. https://doi.org/10.1073/pnas.1820827116
- Open Access
  Correlated interfacial water transport and proton conductivity in perfluorosulfonic acid membranes
  Xiao Ling, Mischa Bonn, Katrin F. Domke, and Sapun H. Parekh
  
  PNAS April 30, 2019 116 (18) 8715-8720; first published April 15, 2019. https://doi.org/10.1073/pnas.1817470116
- Open Access
  Modular, stereocontrolled C_β–H/C_α–C activation of alkyl carboxylic acids
  Ming Shang, Karla S. Feu, Julien C. Vantourout, Lisa M. Barton, Heather L. Osswald, Nobutaka Kato, Kerstin Gagaring, Case W. McNamara, Gang Chen, Liang Hu, Shengyang Ni, Paula Fernández-Canelas, Miao Chen, Rohan R. Merchant, Tian Qin, Stuart L. Schreiber, Bruno Melillo, Jin-Quan Yu, and Phil S. Baran
  
  PNAS April 30, 2019 116 (18) 8721-8727; first published April 17, 2019. https://doi.org/10.1073/pnas.1903048116
Computer Sciences
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  Machine learning-assisted directed protein evolution with combinatorial libraries
  Zachary Wu, S. B. Jennifer Kan, Russell D. Lewis, Bruce J. Wittmann, and Frances H. Arnold
  
  PNAS April 30, 2019 116 (18) 8852-8858; first published April 12, 2019. https://doi.org/10.1073/pnas.1901979116
Earth, Atmospheric, and Planetary Sciences
- Open Access
  Severe haze in northern China: A synergy of anthropogenic emissions and atmospheric processes
  Inaugural Article
  
  Zhisheng An, Ru-Jin Huang, Renyi Zhang, Xuexi Tie, Guohui Li, Junji Cao, Weijian Zhou, Zhengguo Shi, Yongming Han, Zhaolin Gu, and Yuemeng Ji
  
  PNAS April 30, 2019 116 (18) 8657-8666; first published April 15, 2019. https://doi.org/10.1073/pnas.1900125116
  
  See companion article:
  Profile of Zhisheng An
  - Apr 15, 2019
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  Climate models can correctly simulate the continuum of global-average temperature variability
  Feng Zhu, Julien Emile-Geay, Nicholas P. McKay, Gregory J. Hakim, Deborah Khider, Toby R. Ault, Eric J. Steig, Sylvia Dee, and James W. Kirchner
  
  PNAS April 30, 2019 116 (18) 8728-8733; first published April 15, 2019. https://doi.org/10.1073/pnas.1809959116
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  Anthropogenic strath terrace formation caused by reduced sediment retention
  Sarah A. Schanz, David R. Montgomery, and Brian D. Collins
  
  PNAS April 30, 2019 116 (18) 8734-8739; first published April 15, 2019. https://doi.org/10.1073/pnas.1814627116
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  K isotopes as a tracer for continental weathering and geological K cycling
  Shilei Li, Weiqiang Li, Brian L. Beard, Maureen E. Raymo, Xiaomin Wang, Yang Chen, and Jun Chen
  
  PNAS April 30, 2019 116 (18) 8740-8745; first published April 15, 2019. https://doi.org/10.1073/pnas.1811282116
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  Neoproterozoic to early Phanerozoic rise in island arc redox state due to deep ocean oxygenation and increased marine sulfate levels
  Daniel A. Stolper and Claire E. Bucholz
  
  PNAS April 30, 2019 116 (18) 8746-8755; first published April 11, 2019. https://doi.org/10.1073/pnas.1821847116
Engineering
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  Disconnection description of triple-junction motion
  Spencer L. Thomas, Chaozhen Wei, Jian Han, Yang Xiang, and David J. Srolovitz
  
  PNAS April 30, 2019 116 (18) 8756-8765; first published April 15, 2019. https://doi.org/10.1073/pnas.1820789116
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  Macromolecular relaxation, strain, and extensibility determine elastocapillary thinning and extensional viscosity of polymer solutions
  Jelena Dinic and Vivek Sharma
  
  PNAS April 30, 2019 116 (18) 8766-8774; first published April 12, 2019. https://doi.org/10.1073/pnas.1820277116
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  Rapid screening of engineered microbial therapies in a 3D multicellular model
  Tetsuhiro Harimoto, Zakary S. Singer, Oscar S. Velazquez, Joanna Zhang, Samuel Castro, Taylor E. Hinchliffe, William Mather, and Tal Danino
  
  PNAS April 30, 2019 116 (18) 9002-9007; first published April 17, 2019. https://doi.org/10.1073/pnas.1820824116
Environmental Sciences
- Open Access
  Fine-scale damage estimates of particulate matter air pollution reveal opportunities for location-specific mitigation of emissions
  Andrew L. Goodkind, Christopher W. Tessum, Jay S. Coggins, Jason D. Hill, and Julian D. Marshall
  
  PNAS April 30, 2019 116 (18) 8775-8780; first published April 8, 2019. https://doi.org/10.1073/pnas.1816102116
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  Dating glacier ice of the last millennium by quantum technology
  Zhongyi Feng, Pascal Bohleber, Sven Ebser, Lisa Ringena, Maximilian Schmidt, Arne Kersting, Philip Hopkins, Helene Hoffmann, Andrea Fischer, Werner Aeschbach, and Markus K. Oberthaler
  
  PNAS April 30, 2019 116 (18) 8781-8786; first published April 17, 2019. https://doi.org/10.1073/pnas.1816468116
Mathematics
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  Counterexamples in scale calculus
  Benjamin Filippenko, Zhengyi Zhou, and Katrin Wehrheim
  
  PNAS April 30, 2019 116 (18) 8787-8797; first published April 12, 2019. https://doi.org/10.1073/pnas.1811701116
Physics
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  Giant nonvolatile resistive switching in a Mott oxide and ferroelectric hybrid
  Pavel Salev, Javier del Valle, Yoav Kalcheim, and Ivan K. Schuller
  
  PNAS April 30, 2019 116 (18) 8798-8802; first published April 11, 2019. https://doi.org/10.1073/pnas.1822138116
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  Strain-induced spontaneous Hall effect in an epitaxial thin film of a Luttinger semimetal
  Takumi Ohtsuki, Zhaoming Tian, Akira Endo, Mario Halim, Shingo Katsumoto, Yoshimitsu Kohama, Koichi Kindo, Mikk Lippmaa, and Satoru Nakatsuji
  
  PNAS April 30, 2019 116 (18) 8803-8808; first published April 15, 2019. https://doi.org/10.1073/pnas.1819489116
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  Phase-conjugate mirror for water waves driven by the Faraday instability
  Vincent Bacot, Guillaume Durey, Antonin Eddi, Mathias Fink, and Emmanuel Fort
  
  PNAS April 30, 2019 116 (18) 8809-8814; first published April 17, 2019. https://doi.org/10.1073/pnas.1818742116
- Open Access
  How a well-adapting immune system remembers
  Andreas Mayer, Vijay Balasubramanian, Aleksandra M. Walczak, and Thierry Mora
  
  PNAS April 30, 2019 116 (18) 8815-8823; first published April 15, 2019. https://doi.org/10.1073/pnas.1812810116

Biological Sciences

Applied Biological Sciences
- You have access
  Machine learning-assisted directed protein evolution with combinatorial libraries
  Zachary Wu, S. B. Jennifer Kan, Russell D. Lewis, Bruce J. Wittmann, and Frances H. Arnold
  
  PNAS April 30, 2019 116 (18) 8852-8858; first published April 12, 2019. https://doi.org/10.1073/pnas.1901979116
Biochemistry
- You have access
  A diecast mineralization process forms the tough mantis shrimp dactyl club
  Shahrouz Amini, Maryam Tadayon, Jun Jie Loke, Akshita Kumar, Deepankumar Kanagavel, Hortense Le Ferrand, Martial Duchamp, Manfred Raida, Radoslaw M. Sobota, Liyan Chen, Shawn Hoon, and Ali Miserez
  
  PNAS April 30, 2019 116 (18) 8685-8692; first published April 11, 2019. https://doi.org/10.1073/pnas.1816835116
- You have access
  Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1
  JuYeon Lee, Yugang Bai, Ullas V. Chembazhi, Shaohong Peng, Kevin Yum, Long M. Luu, Lauren D. Hagler, Julio F. Serrano, H. Y. Edwin Chan, Auinash Kalsotra, and Steven C. Zimmerman
  
  PNAS April 30, 2019 116 (18) 8709-8714; first published April 11, 2019. https://doi.org/10.1073/pnas.1820827116
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  Interaction between p53 N terminus and core domain regulates specific and nonspecific DNA binding
  Fan He, Wade Borcherds, Tanjing Song, Xi Wei, Mousumi Das, Lihong Chen, Gary W. Daughdrill, and Jiandong Chen
  
  PNAS April 30, 2019 116 (18) 8859-8868; first published April 15, 2019. https://doi.org/10.1073/pnas.1903077116
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  Structural insight into TRPV5 channel function and modulation
  Shangyu Dang, Mark K. van Goor, Daniel Asarnow, YongQiang Wang, David Julius, Yifan Cheng, and Jenny van der Wijst
  
  PNAS April 30, 2019 116 (18) 8869-8878; first published April 11, 2019. https://doi.org/10.1073/pnas.1820323116
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  Cytosolic Fe-superoxide dismutase safeguards Trypanosoma cruzi from macrophage-derived superoxide radical
  Alejandra Martínez, Carolina Prolo, Damián Estrada, Natalia Rios, María Noel Alvarez, María Dolores Piñeyro, Carlos Robello, Rafael Radi, and Lucía Piacenza
  
  PNAS April 30, 2019 116 (18) 8879-8888; first published April 12, 2019. https://doi.org/10.1073/pnas.1821487116
Biophysics and Computational Biology
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  Commonly used FRET fluorophores promote collapse of an otherwise disordered protein
  Joshua A. Riback, Micayla A. Bowman, Adam M. Zmyslowski, Kevin W. Plaxco, Patricia L. Clark, and Tobin R. Sosnick
  
  PNAS April 30, 2019 116 (18) 8889-8894; first published April 16, 2019. https://doi.org/10.1073/pnas.1813038116
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  α-Sheet secondary structure in amyloid β-peptide drives aggregation and toxicity in Alzheimer’s disease
  Dylan Shea, Cheng-Chieh Hsu, Timothy M. Bi, Natasha Paranjapye, Matthew Carter Childers, Joshua Cochran, Colson P. Tomberlin, Libo Wang, Daniel Paris, Jeffrey Zonderman, Gabriele Varani, Christopher D. Link, Mike Mullan, and Valerie Daggett
  
  PNAS April 30, 2019 116 (18) 8895-8900; first published April 19, 2019. https://doi.org/10.1073/pnas.1820585116
- Open Access
  Coherent directed movement toward food modeled in Trichoplax, a ciliated animal lacking a nervous system
  Carolyn L. Smith, Thomas S. Reese, Tzipe Govezensky, and Rafael A. Barrio
  
  PNAS April 30, 2019 116 (18) 8901-8908; first published April 12, 2019. https://doi.org/10.1073/pnas.1815655116
Cell Biology
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  Distinct segregation patterns of yeast cell-peripheral proteins uncovered by a method for protein segregatome analysis
  Shinju Sugiyama and Motomasa Tanaka
  
  PNAS April 30, 2019 116 (18) 8909-8918; first published April 11, 2019. https://doi.org/10.1073/pnas.1819715116
Ecology
- Open Access
  Early tropical crop production in marginal subtropical and temperate Polynesia
  From the Cover
  
  Matthew Prebble, Atholl J. Anderson, Paul Augustinus, Joshua Emmitt, Stewart J. Fallon, Louise L. Furey, Simon J. Holdaway, Alex Jorgensen, Thegn N. Ladefoged, Peter J. Matthews, Jean-Yves Meyer, Rebecca Phillipps, Rod Wallace, and Nicholas Porch
  
  PNAS April 30, 2019 116 (18) 8824-8833; first published April 8, 2019. https://doi.org/10.1073/pnas.1821732116
  
  See companion article:
  Reply to Barber: Marginal evidence for taro production in northern New Zealand between 1200 and 1500 CE
  - Jan 14, 2020
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  Social alliances improve rank and fitness in convention-based societies
  From the Cover
  
  Eli D. Strauss and Kay E. Holekamp
  
  PNAS April 30, 2019 116 (18) 8919-8924; first published March 11, 2019. https://doi.org/10.1073/pnas.1810384116
  
  See companion article:
  Hyena politics: The dynamics of dynasties
  - Mar 25, 2019
- You have access
  Predators attacking virtual prey reveal the costs and benefits of leadership
  Christos C. Ioannou, Florence Rocque, James E. Herbert-Read, Callum Duffield, and Josh A. Firth
  
  PNAS April 30, 2019 116 (18) 8925-8930; first published April 15, 2019. https://doi.org/10.1073/pnas.1816323116
Environmental Sciences
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  Environmental DNA for improved detection and environmental surveillance of schistosomiasis
  Mita E. Sengupta, Micaela Hellström, Henry C. Kariuki, Annette Olsen, Philip F. Thomsen, Helena Mejer, Eske Willerslev, Mariam T. Mwanje, Henry Madsen, Thomas K. Kristensen, Anna-Sofie Stensgaard, and Birgitte J. Vennervald
  
  PNAS April 30, 2019 116 (18) 8931-8940; first published April 11, 2019. https://doi.org/10.1073/pnas.1815046116
Evolution
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  Evolution of social norms and correlated equilibria
  Bryce Morsky and Erol Akçay
  
  PNAS April 30, 2019 116 (18) 8834-8839; first published April 11, 2019. https://doi.org/10.1073/pnas.1817095116
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  Testing the role of trait reversal in evolutionary diversification using song loss in wild crickets
  Nathan W. Bailey, Sonia Pascoal, and Fernando Montealegre-Z
  
  PNAS April 30, 2019 116 (18) 8941-8949; first published April 16, 2019. https://doi.org/10.1073/pnas.1818998116
- Open Access
  Exaggeration and cooption of innate immunity for social defense
  Mayako Kutsukake, Minoru Moriyama, Shuji Shigenobu, Xian-Ying Meng, Naruo Nikoh, Chiyo Noda, Satoru Kobayashi, and Takema Fukatsu
  
  PNAS April 30, 2019 116 (18) 8950-8959; first published April 15, 2019. https://doi.org/10.1073/pnas.1900917116
Genetics
- Open Access
  Functional characterization of 3D protein structures informed by human genetic diversity
  Michael Hicks, Istvan Bartha, Julia di Iulio, J. Craig Venter, and Amalio Telenti
  
  PNAS April 30, 2019 116 (18) 8960-8965; first published April 15, 2019. https://doi.org/10.1073/pnas.1820813116
Immunology and Inflammation
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  Designer covalent heterobivalent inhibitors prevent IgE-dependent responses to peanut allergen
  From the Cover
  
  Peter E. Deak, Baksun Kim, Amina Abdul Qayum, Jaeho Shin, Girish Vitalpur, Kirsten M. Kloepfer, Matthew J. Turner, Neal Smith, Wayne G. Shreffler, Tanyel Kiziltepe, Mark H. Kaplan, and Basar Bilgicer
  
  PNAS April 30, 2019 116 (18) 8966-8974; first published April 8, 2019. https://doi.org/10.1073/pnas.1820417116
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  Hypoxia-inducible factors in CD4⁺ T cells promote metabolism, switch cytokine secretion, and T cell help in humoral immunity
  Sung Hoon Cho, Ariel L. Raybuck, Julianna Blagih, Edna Kemboi, Volker H. Haase, Russell G. Jones, and Mark R. Boothby
  
  PNAS April 30, 2019 116 (18) 8975-8984; first published April 15, 2019. https://doi.org/10.1073/pnas.1811702116
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  DNA threads released by activated CD4⁺ T lymphocytes provide autocrine costimulation
  Massimo Costanza, Pietro L. Poliani, Paola Portararo, Barbara Cappetti, Silvia Musio, Francesca Pagani, Lawrence Steinman, Mario P. Colombo, Rosetta Pedotti, and Sabina Sangaletti
  
  PNAS April 30, 2019 116 (18) 8985-8994; first published April 15, 2019. https://doi.org/10.1073/pnas.1822013116
- Open Access
  Select sequencing of clonally expanded CD8⁺ T cells reveals limits to clonal expansion
  Huang Huang, Michael J. Sikora, Saiful Islam, Roshni Roy Chowdhury, Yueh-hsiu Chien, Thomas J. Scriba, Mark M. Davis, and Lars M. Steinmetz
  
  PNAS April 30, 2019 116 (18) 8995-9001; first published April 16, 2019. https://doi.org/10.1073/pnas.1902649116
Medical Sciences
- You have access
  Rapid screening of engineered microbial therapies in a 3D multicellular model
  Tetsuhiro Harimoto, Zakary S. Singer, Oscar S. Velazquez, Joanna Zhang, Samuel Castro, Taylor E. Hinchliffe, William Mather, and Tal Danino
  
  PNAS April 30, 2019 116 (18) 9002-9007; first published April 17, 2019. https://doi.org/10.1073/pnas.1820824116
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  Inherited predisposition to malignant mesothelioma and overall survival following platinum chemotherapy
  Raffit Hassan, Betsy Morrow, Anish Thomas, Tom Walsh, Ming K. Lee, Suleyman Gulsuner, Meghana Gadiraju, Vasiliki Panou, Shaojian Gao, Idrees Mian, Javed Khan, Mark Raffeld, Snehal Patel, Liqiang Xi, Jun S. Wei, Mary Hesdorffer, Jingli Zhang, Kathleen Calzone, Arpita Desai, Emerson Padiernos, Christine Alewine, David S. Schrump, Seth M. Steinberg, Hedy L. Kindler, Mary-Claire King, and Jane E. Churpek
  
  PNAS April 30, 2019 116 (18) 9008-9013; first published April 11, 2019. https://doi.org/10.1073/pnas.1821510116
- Open Access
  Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan
  Lei Zhang, Xiao Dong, Moonsook Lee, Alexander Y. Maslov, Tao Wang, and Jan Vijg
  
  PNAS April 30, 2019 116 (18) 9014-9019; first published April 16, 2019. https://doi.org/10.1073/pnas.1902510116
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  Cancer stemness, intratumoral heterogeneity, and immune response across cancers
  Alex Miranda, Phineas T. Hamilton, Allen W. Zhang, Swetansu Pattnaik, Etienne Becht, Artur Mezheyeuski, Jarle Bruun, Patrick Micke, Aurélien de Reynies, and Brad H. Nelson
  
  PNAS April 30, 2019 116 (18) 9020-9029; first published April 17, 2019. https://doi.org/10.1073/pnas.1818210116
- Open Access
  Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis
  From the Cover
  
  Alexandra M. Nicaise, Laura J. Wagstaff, Cory M. Willis, Carolyn Paisie, Harshpreet Chandok, Paul Robson, Valentina Fossati, Anna Williams, and Stephen J. Crocker
  
  PNAS April 30, 2019 116 (18) 9030-9039; first published March 25, 2019. https://doi.org/10.1073/pnas.1818348116
  
  See companion article:
  New age for progressive multiple sclerosis
  - Apr 19, 2019
Microbiology
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  Mutations in the HIV-1 envelope glycoprotein can broadly rescue blocks at multiple steps in the virus replication cycle
  Rachel Van Duyne, Lillian S. Kuo, Phuong Pham, Ken Fujii, and Eric O. Freed
  
  PNAS April 30, 2019 116 (18) 9040-9049; first published April 11, 2019. https://doi.org/10.1073/pnas.1820333116
Neuroscience
- Open Access
  Functional connectomics of affective and psychotic pathology
  Justin T. Baker, Daniel G. Dillon, Lauren M. Patrick, Joshua L. Roffman, Roscoe O. Brady Jr., Diego A. Pizzagalli, Dost Öngür, and Avram J. Holmes
  
  PNAS April 30, 2019 116 (18) 9050-9059; first published April 15, 2019. https://doi.org/10.1073/pnas.1820780116
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  Causal inference accounts for heading perception in the presence of object motion
  Kalpana Dokka, Hyeshin Park, Michael Jansen, Gregory C. DeAngelis, and Dora E. Angelaki
  
  PNAS April 30, 2019 116 (18) 9060-9065; first published April 17, 2019. https://doi.org/10.1073/pnas.1820373116
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  Compulsive drug use is associated with imbalance of orbitofrontal- and prelimbic-striatal circuits in punishment-resistant individuals
  Yuzheng Hu, Betty Jo Salmeron, Irina N. Krasnova, Hong Gu, Hanbing Lu, Antonello Bonci, Jean L. Cadet, Elliot A. Stein, and Yihong Yang
  
  PNAS April 30, 2019 116 (18) 9066-9071; first published April 15, 2019. https://doi.org/10.1073/pnas.1819978116
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  Modulation of fear generalization by the zona incerta
  Archana Venkataraman, Natalia Brody, Preethi Reddi, Jidong Guo, Donald Gordon Rainnie, and Brian George Dias
  
  PNAS April 30, 2019 116 (18) 9072-9077; first published April 9, 2019. https://doi.org/10.1073/pnas.1820541116
- Open Access
  Reduced default mode network functional connectivity in patients with recurrent major depressive disorder
  Chao-Gan Yan, Xiao Chen, Le Li, Francisco Xavier Castellanos, Tong-Jian Bai, Qi-Jing Bo, Jun Cao, Guan-Mao Chen, Ning-Xuan Chen, Wei Chen, Chang Cheng, Yu-Qi Cheng, Xi-Long Cui, Jia Duan, Yi-Ru Fang, Qi-Yong Gong, Wen-Bin Guo, Zheng-Hua Hou, Lan Hu, Li Kuang, Feng Li, Kai-Ming Li, Tao Li, Yan-Song Liu, Zhe-Ning Liu, Yi-Cheng Long, Qing-Hua Luo, Hua-Qing Meng, Dai-Hui Peng, Hai-Tang Qiu, Jiang Qiu, Yue-Di Shen, Yu-Shu Shi, Chuan-Yue Wang, Fei Wang, Kai Wang, Li Wang, Xiang Wang, Ying Wang, Xiao-Ping Wu, Xin-Ran Wu, Chun-Ming Xie, Guang-Rong Xie, Hai-Yan Xie, Peng Xie, Xiu-Feng Xu, Hong Yang, Jian Yang, Jia-Shu Yao, Shu-Qiao Yao, Ying-Ying Yin, Yong-Gui Yuan, Ai-Xia Zhang, Hong Zhang, Ke-Rang Zhang, Lei Zhang, Zhi-Jun Zhang, Ru-Bai Zhou, Yi-Ting Zhou, Jun-Juan Zhu, Chao-Jie Zou, Tian-Mei Si, Xi-Nian Zuo, Jing-Ping Zhao, and Yu-Feng Zang
  
  PNAS April 30, 2019 116 (18) 9078-9083; first published April 12, 2019. https://doi.org/10.1073/pnas.1900390116
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  Intrinsic planar polarity mechanisms influence the position-dependent regulation of synapse properties in inner hair cells
  Philippe Jean, Özge Demet Özçete, Basile Tarchini, and Tobias Moser
  
  PNAS April 30, 2019 116 (18) 9084-9093; first published April 11, 2019. https://doi.org/10.1073/pnas.1818358116
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  Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer’s disease pathologies
  Jie Xiang, Zhi-Hao Wang, Eun Hee Ahn, Xia Liu, Shan-Ping Yu, Fredric P. Manfredsson, Ivette M. Sandoval, Gong Ju, Shengxi Wu, and Keqiang Ye
  
  PNAS April 30, 2019 116 (18) 9094-9102; first published April 19, 2019. https://doi.org/10.1073/pnas.1901348116
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  Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain studied at single-cell resolution
  Jacob S. Heng, Amir Rattner, Genevieve L. Stein-O’Brien, Briana L. Winer, Bryan W. Jones, Hilary J. Vernon, Loyal A. Goff, and Jeremy Nathans
  
  PNAS April 30, 2019 116 (18) 9103-9114; first published April 15, 2019. https://doi.org/10.1073/pnas.1821122116
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  Protease-independent action of tissue plasminogen activator in brain plasticity and neurological recovery after ischemic stroke
  Hongjian Pu, Yejie Shi, Lili Zhang, Zhengyu Lu, Qing Ye, Rehana K. Leak, Fei Xu, Shubei Ma, Hongfeng Mu, Zhishuo Wei, Na Xu, Yuguo Xia, Xiaoming Hu, T. Kevin Hitchens, Michael V. L. Bennett, and Jun Chen
  
  PNAS April 30, 2019 116 (18) 9115-9124; first published April 17, 2019. https://doi.org/10.1073/pnas.1821979116
Physiology
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  Constitutive release of CPS1 in bile and its role as a protective cytokine during acute liver injury
  Min-Jung Park, Louis G. D’Alecy, Michelle A. Anderson, Venkatesha Basrur, Yongjia Feng, Graham F. Brady, Dong-il Kim, Jun Wu, Alexey I. Nesvizhskii, Joerg Lahann, Nicholas W. Lukacs, Robert J. Fontana, and M. Bishr Omary
  
  PNAS April 30, 2019 116 (18) 9125-9134; first published April 12, 2019. https://doi.org/10.1073/pnas.1822173116

Corrections

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Correction for Drollette et al., Elevated levels of diesel range organic compounds in groundwater near Marcellus gas operations are derived from surface activities
PNAS April 30, 2019 116 (18) 9135; first published April 22, 2019. https://doi.org/10.1073/pnas.1905353116
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Correction for Khoddami et al., Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution
PNAS April 30, 2019 116 (18) 9136; first published April 22, 2019. https://doi.org/10.1073/pnas.1905628116
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Correction for Tang and Dubayah, Light-driven growth in Amazon evergreen forests explained by seasonal variations of vertical canopy structure
PNAS April 30, 2019 116 (18) 9137; first published April 23, 2019. https://doi.org/10.1073/pnas.1905220116

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