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Table of Contents

April 30, 2019; vol. 116 no. 18

This Week in PNAS

  • You have access
    In This Issue
    PNAS April 30, 2019 116 (18) 8635-8637; https://doi.org/10.1073/iti1819116

Inner Workings

An over-the-shoulder look at scientists at work.
  • You have access
    Inner Workings: Genomics blazes a trail to improved cannabis cultivation
    • Front Matter
    Elie Dolgin
    PNAS April 30, 2019 116 (18) 8638-8640; https://doi.org/10.1073/pnas.1904094116

Profile

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    Profile of Zhisheng An
    Jennifer Viegas
    PNAS April 30, 2019 116 (18) 8641-8643; first published April 15, 2019. https://doi.org/10.1073/pnas.1904581116

    See companion article:

    • Severe haze in northern China: A synergy of anthropogenic emissions and atmospheric processes
      - Apr 15, 2019

Commentaries

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    Hyena politics: The dynamics of dynasties
    Joan B. Silk
    PNAS April 30, 2019 116 (18) 8644-8645; first published March 25, 2019. https://doi.org/10.1073/pnas.1903407116

    See companion article:

    • Social alliances improve rank and fitness in convention-based societies
      - Mar 11, 2019
  • You have access
    New age for progressive multiple sclerosis
    Jaime Imitola
    PNAS April 30, 2019 116 (18) 8646-8648; first published April 19, 2019. https://doi.org/10.1073/pnas.1903796116

    See companion article:

    • Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis
      - Mar 25, 2019

Letters

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    Time domain versus energy domain neutron scattering analysis of protein dynamics
    Wolfgang Doster
    PNAS April 30, 2019 116 (18) 8649-8650; first published April 12, 2019. https://doi.org/10.1073/pnas.1821562116
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    Reply to Doster: Franck–Condon and Van Hove formulation of quasielastic neutron scattering from complex systems
    Gerald R. Kneller
    PNAS April 30, 2019 116 (18) 8651-8652; first published April 12, 2019. https://doi.org/10.1073/pnas.1901851116

    See companion article:

    • Franck–Condon picture of incoherent neutron scattering
      - Aug 30, 2018
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    Phototransduction gain at the G-protein, transducin, and effector protein, phosphodiesterase-6, stages in retinal rods
    Martin Heck, Klaus Peter Hofmann, Timothy W. Kraft, and Trevor D. Lamb
    PNAS April 30, 2019 116 (18) 8653-8654; first published April 30, 2019. https://doi.org/10.1073/pnas.1904017116
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    Reply to Heck et al.: Signal amplification at the rhodopsin-to-transducin·phosphodiesterase step in rod phototransduction
    K.-W. Yau, W. W. S. Yue, and D. Silverman
    PNAS April 30, 2019 116 (18) 8655-8656; first published April 30, 2019. https://doi.org/10.1073/pnas.1904339116

    See companion article:

    • Elementary response triggered by transducin in retinal rods
      - Feb 22, 2019

Physical Sciences

  • Applied Physical Sciences

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      Deep learning in turbulent convection networks
      Enrico Fonda, Ambrish Pandey, Jörg Schumacher, and Katepalli R. Sreenivasan
      PNAS April 30, 2019 116 (18) 8667-8672; first published April 15, 2019. https://doi.org/10.1073/pnas.1900358116
    • Open Access
      Scale-free resilience of real traffic jams
      Limiao Zhang, Guanwen Zeng, Daqing Li, Hai-Jun Huang, H. Eugene Stanley, and Shlomo Havlin
      PNAS April 30, 2019 116 (18) 8673-8678; first published April 12, 2019. https://doi.org/10.1073/pnas.1814982116
    • Open Access
      Shock growth of ice crystal near equilibrium melting pressure under dynamic compression
      Yong-Jae Kim, Yun-Hee Lee, Sooheyong Lee, Hiroki Nada, and Geun Woo Lee
      PNAS April 30, 2019 116 (18) 8679-8684; first published April 15, 2019. https://doi.org/10.1073/pnas.1818122116
  • Biophysics and Computational Biology

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      A diecast mineralization process forms the tough mantis shrimp dactyl club
      Shahrouz Amini, Maryam Tadayon, Jun Jie Loke, Akshita Kumar, Deepankumar Kanagavel, Hortense Le Ferrand, Martial Duchamp, Manfred Raida, Radoslaw M. Sobota, Liyan Chen, Shawn Hoon, and Ali Miserez
      PNAS April 30, 2019 116 (18) 8685-8692; first published April 11, 2019. https://doi.org/10.1073/pnas.1816835116
    • You have access
      Unified energetics analysis unravels SpCas9 cleavage activity for optimal gRNA design
      Dong Zhang, Travis Hurst, Dongsheng Duan, and Shi-Jie Chen
      PNAS April 30, 2019 116 (18) 8693-8698; first published April 15, 2019. https://doi.org/10.1073/pnas.1820523116
    • Open Access
      Structural dynamics and transient lipid binding of synaptobrevin-2 tune SNARE assembly and membrane fusion
      Nils-Alexander Lakomek, Halenur Yavuz, Reinhard Jahn, and Ángel Pérez-Lara
      PNAS April 30, 2019 116 (18) 8699-8708; first published April 11, 2019. https://doi.org/10.1073/pnas.1813194116
    • You have access
      Commonly used FRET fluorophores promote collapse of an otherwise disordered protein
      Joshua A. Riback, Micayla A. Bowman, Adam M. Zmyslowski, Kevin W. Plaxco, Patricia L. Clark, and Tobin R. Sosnick
      PNAS April 30, 2019 116 (18) 8889-8894; first published April 16, 2019. https://doi.org/10.1073/pnas.1813038116
  • Chemistry

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      Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1
      JuYeon Lee, Yugang Bai, Ullas V. Chembazhi, Shaohong Peng, Kevin Yum, Long M. Luu, Lauren D. Hagler, Julio F. Serrano, H. Y. Edwin Chan, Auinash Kalsotra, and Steven C. Zimmerman
      PNAS April 30, 2019 116 (18) 8709-8714; first published April 11, 2019. https://doi.org/10.1073/pnas.1820827116
    • Open Access
      Correlated interfacial water transport and proton conductivity in perfluorosulfonic acid membranes
      Xiao Ling, Mischa Bonn, Katrin F. Domke, and Sapun H. Parekh
      PNAS April 30, 2019 116 (18) 8715-8720; first published April 15, 2019. https://doi.org/10.1073/pnas.1817470116
    • Open Access
      Modular, stereocontrolled Cβ–H/Cα–C activation of alkyl carboxylic acids
      Ming Shang, Karla S. Feu, Julien C. Vantourout, Lisa M. Barton, Heather L. Osswald, Nobutaka Kato, Kerstin Gagaring, Case W. McNamara, Gang Chen, Liang Hu, Shengyang Ni, Paula Fernández-Canelas, Miao Chen, Rohan R. Merchant, Tian Qin, Stuart L. Schreiber, Bruno Melillo, Jin-Quan Yu, and Phil S. Baran
      PNAS April 30, 2019 116 (18) 8721-8727; first published April 17, 2019. https://doi.org/10.1073/pnas.1903048116
  • Computer Sciences

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      Machine learning-assisted directed protein evolution with combinatorial libraries
      Zachary Wu, S. B. Jennifer Kan, Russell D. Lewis, Bruce J. Wittmann, and Frances H. Arnold
      PNAS April 30, 2019 116 (18) 8852-8858; first published April 12, 2019. https://doi.org/10.1073/pnas.1901979116
  • Earth, Atmospheric, and Planetary Sciences

    • Open Access
      Severe haze in northern China: A synergy of anthropogenic emissions and atmospheric processes
      • Inaugural Article
      Zhisheng An, Ru-Jin Huang, Renyi Zhang, Xuexi Tie, Guohui Li, Junji Cao, Weijian Zhou, Zhengguo Shi, Yongming Han, Zhaolin Gu, and Yuemeng Ji
      PNAS April 30, 2019 116 (18) 8657-8666; first published April 15, 2019. https://doi.org/10.1073/pnas.1900125116

      See companion article:

      • Profile of Zhisheng An
        - Apr 15, 2019
    • You have access
      Climate models can correctly simulate the continuum of global-average temperature variability
      Feng Zhu, Julien Emile-Geay, Nicholas P. McKay, Gregory J. Hakim, Deborah Khider, Toby R. Ault, Eric J. Steig, Sylvia Dee, and James W. Kirchner
      PNAS April 30, 2019 116 (18) 8728-8733; first published April 15, 2019. https://doi.org/10.1073/pnas.1809959116
    • You have access
      Anthropogenic strath terrace formation caused by reduced sediment retention
      Sarah A. Schanz, David R. Montgomery, and Brian D. Collins
      PNAS April 30, 2019 116 (18) 8734-8739; first published April 15, 2019. https://doi.org/10.1073/pnas.1814627116
    • You have access
      K isotopes as a tracer for continental weathering and geological K cycling
      Shilei Li, Weiqiang Li, Brian L. Beard, Maureen E. Raymo, Xiaomin Wang, Yang Chen, and Jun Chen
      PNAS April 30, 2019 116 (18) 8740-8745; first published April 15, 2019. https://doi.org/10.1073/pnas.1811282116
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      Neoproterozoic to early Phanerozoic rise in island arc redox state due to deep ocean oxygenation and increased marine sulfate levels
      Daniel A. Stolper and Claire E. Bucholz
      PNAS April 30, 2019 116 (18) 8746-8755; first published April 11, 2019. https://doi.org/10.1073/pnas.1821847116
  • Engineering

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      Disconnection description of triple-junction motion
      Spencer L. Thomas, Chaozhen Wei, Jian Han, Yang Xiang, and David J. Srolovitz
      PNAS April 30, 2019 116 (18) 8756-8765; first published April 15, 2019. https://doi.org/10.1073/pnas.1820789116
    • You have access
      Macromolecular relaxation, strain, and extensibility determine elastocapillary thinning and extensional viscosity of polymer solutions
      Jelena Dinic and Vivek Sharma
      PNAS April 30, 2019 116 (18) 8766-8774; first published April 12, 2019. https://doi.org/10.1073/pnas.1820277116
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      Rapid screening of engineered microbial therapies in a 3D multicellular model
      Tetsuhiro Harimoto, Zakary S. Singer, Oscar S. Velazquez, Joanna Zhang, Samuel Castro, Taylor E. Hinchliffe, William Mather, and Tal Danino
      PNAS April 30, 2019 116 (18) 9002-9007; first published April 17, 2019. https://doi.org/10.1073/pnas.1820824116
  • Environmental Sciences

    • Open Access
      Fine-scale damage estimates of particulate matter air pollution reveal opportunities for location-specific mitigation of emissions
      Andrew L. Goodkind, Christopher W. Tessum, Jay S. Coggins, Jason D. Hill, and Julian D. Marshall
      PNAS April 30, 2019 116 (18) 8775-8780; first published April 8, 2019. https://doi.org/10.1073/pnas.1816102116
    • You have access
      Dating glacier ice of the last millennium by quantum technology
      Zhongyi Feng, Pascal Bohleber, Sven Ebser, Lisa Ringena, Maximilian Schmidt, Arne Kersting, Philip Hopkins, Helene Hoffmann, Andrea Fischer, Werner Aeschbach, and Markus K. Oberthaler
      PNAS April 30, 2019 116 (18) 8781-8786; first published April 17, 2019. https://doi.org/10.1073/pnas.1816468116
  • Mathematics

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      Counterexamples in scale calculus
      Benjamin Filippenko, Zhengyi Zhou, and Katrin Wehrheim
      PNAS April 30, 2019 116 (18) 8787-8797; first published April 12, 2019. https://doi.org/10.1073/pnas.1811701116
  • Physics

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      Giant nonvolatile resistive switching in a Mott oxide and ferroelectric hybrid
      Pavel Salev, Javier del Valle, Yoav Kalcheim, and Ivan K. Schuller
      PNAS April 30, 2019 116 (18) 8798-8802; first published April 11, 2019. https://doi.org/10.1073/pnas.1822138116
    • You have access
      Strain-induced spontaneous Hall effect in an epitaxial thin film of a Luttinger semimetal
      Takumi Ohtsuki, Zhaoming Tian, Akira Endo, Mario Halim, Shingo Katsumoto, Yoshimitsu Kohama, Koichi Kindo, Mikk Lippmaa, and Satoru Nakatsuji
      PNAS April 30, 2019 116 (18) 8803-8808; first published April 15, 2019. https://doi.org/10.1073/pnas.1819489116
    • You have access
      Phase-conjugate mirror for water waves driven by the Faraday instability
      Vincent Bacot, Guillaume Durey, Antonin Eddi, Mathias Fink, and Emmanuel Fort
      PNAS April 30, 2019 116 (18) 8809-8814; first published April 17, 2019. https://doi.org/10.1073/pnas.1818742116
    • Open Access
      How a well-adapting immune system remembers
      Andreas Mayer, Vijay Balasubramanian, Aleksandra M. Walczak, and Thierry Mora
      PNAS April 30, 2019 116 (18) 8815-8823; first published April 15, 2019. https://doi.org/10.1073/pnas.1812810116

Social Sciences

  • Anthropology

    • Open Access
      Early tropical crop production in marginal subtropical and temperate Polynesia
      • From the Cover
      Matthew Prebble, Atholl J. Anderson, Paul Augustinus, Joshua Emmitt, Stewart J. Fallon, Louise L. Furey, Simon J. Holdaway, Alex Jorgensen, Thegn N. Ladefoged, Peter J. Matthews, Jean-Yves Meyer, Rebecca Phillipps, Rod Wallace, and Nicholas Porch
      PNAS April 30, 2019 116 (18) 8824-8833; first published April 8, 2019. https://doi.org/10.1073/pnas.1821732116

      See companion article:

      • Reply to Barber: Marginal evidence for taro production in northern New Zealand between 1200 and 1500 CE
        - Jan 14, 2020
  • Economic Sciences

    • You have access
      Evolution of social norms and correlated equilibria
      Bryce Morsky and Erol Akçay
      PNAS April 30, 2019 116 (18) 8834-8839; first published April 11, 2019. https://doi.org/10.1073/pnas.1817095116
  • Environmental Sciences

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      Climate change and educational attainment in the global tropics
      Heather Randell and Clark Gray
      PNAS April 30, 2019 116 (18) 8840-8845; first published April 15, 2019. https://doi.org/10.1073/pnas.1817480116
  • Psychological and Cognitive Sciences

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      Same-sex marriage legalization associated with reduced implicit and explicit antigay bias
      • From the Cover
      Eugene K. Ofosu, Michelle K. Chambers, Jacqueline M. Chen, and Eric Hehman
      PNAS April 30, 2019 116 (18) 8846-8851; first published April 15, 2019. https://doi.org/10.1073/pnas.1806000116
    • Open Access
      Functional connectomics of affective and psychotic pathology
      Justin T. Baker, Daniel G. Dillon, Lauren M. Patrick, Joshua L. Roffman, Roscoe O. Brady Jr., Diego A. Pizzagalli, Dost Öngür, and Avram J. Holmes
      PNAS April 30, 2019 116 (18) 9050-9059; first published April 15, 2019. https://doi.org/10.1073/pnas.1820780116
  • Sustainability Science

    • Open Access
      Fine-scale damage estimates of particulate matter air pollution reveal opportunities for location-specific mitigation of emissions
      Andrew L. Goodkind, Christopher W. Tessum, Jay S. Coggins, Jason D. Hill, and Julian D. Marshall
      PNAS April 30, 2019 116 (18) 8775-8780; first published April 8, 2019. https://doi.org/10.1073/pnas.1816102116
    • You have access
      Climate change and educational attainment in the global tropics
      Heather Randell and Clark Gray
      PNAS April 30, 2019 116 (18) 8840-8845; first published April 15, 2019. https://doi.org/10.1073/pnas.1817480116

Biological Sciences

  • Applied Biological Sciences

    • You have access
      Machine learning-assisted directed protein evolution with combinatorial libraries
      Zachary Wu, S. B. Jennifer Kan, Russell D. Lewis, Bruce J. Wittmann, and Frances H. Arnold
      PNAS April 30, 2019 116 (18) 8852-8858; first published April 12, 2019. https://doi.org/10.1073/pnas.1901979116
  • Biochemistry

    • You have access
      A diecast mineralization process forms the tough mantis shrimp dactyl club
      Shahrouz Amini, Maryam Tadayon, Jun Jie Loke, Akshita Kumar, Deepankumar Kanagavel, Hortense Le Ferrand, Martial Duchamp, Manfred Raida, Radoslaw M. Sobota, Liyan Chen, Shawn Hoon, and Ali Miserez
      PNAS April 30, 2019 116 (18) 8685-8692; first published April 11, 2019. https://doi.org/10.1073/pnas.1816835116
    • You have access
      Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1
      JuYeon Lee, Yugang Bai, Ullas V. Chembazhi, Shaohong Peng, Kevin Yum, Long M. Luu, Lauren D. Hagler, Julio F. Serrano, H. Y. Edwin Chan, Auinash Kalsotra, and Steven C. Zimmerman
      PNAS April 30, 2019 116 (18) 8709-8714; first published April 11, 2019. https://doi.org/10.1073/pnas.1820827116
    • You have access
      Interaction between p53 N terminus and core domain regulates specific and nonspecific DNA binding
      Fan He, Wade Borcherds, Tanjing Song, Xi Wei, Mousumi Das, Lihong Chen, Gary W. Daughdrill, and Jiandong Chen
      PNAS April 30, 2019 116 (18) 8859-8868; first published April 15, 2019. https://doi.org/10.1073/pnas.1903077116
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      Structural insight into TRPV5 channel function and modulation
      Shangyu Dang, Mark K. van Goor, Daniel Asarnow, YongQiang Wang, David Julius, Yifan Cheng, and Jenny van der Wijst
      PNAS April 30, 2019 116 (18) 8869-8878; first published April 11, 2019. https://doi.org/10.1073/pnas.1820323116
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      Cytosolic Fe-superoxide dismutase safeguards Trypanosoma cruzi from macrophage-derived superoxide radical
      Alejandra Martínez, Carolina Prolo, Damián Estrada, Natalia Rios, María Noel Alvarez, María Dolores Piñeyro, Carlos Robello, Rafael Radi, and Lucía Piacenza
      PNAS April 30, 2019 116 (18) 8879-8888; first published April 12, 2019. https://doi.org/10.1073/pnas.1821487116
  • Biophysics and Computational Biology

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      Commonly used FRET fluorophores promote collapse of an otherwise disordered protein
      Joshua A. Riback, Micayla A. Bowman, Adam M. Zmyslowski, Kevin W. Plaxco, Patricia L. Clark, and Tobin R. Sosnick
      PNAS April 30, 2019 116 (18) 8889-8894; first published April 16, 2019. https://doi.org/10.1073/pnas.1813038116
    • You have access
      α-Sheet secondary structure in amyloid β-peptide drives aggregation and toxicity in Alzheimer’s disease
      Dylan Shea, Cheng-Chieh Hsu, Timothy M. Bi, Natasha Paranjapye, Matthew Carter Childers, Joshua Cochran, Colson P. Tomberlin, Libo Wang, Daniel Paris, Jeffrey Zonderman, Gabriele Varani, Christopher D. Link, Mike Mullan, and Valerie Daggett
      PNAS April 30, 2019 116 (18) 8895-8900; first published April 19, 2019. https://doi.org/10.1073/pnas.1820585116
    • Open Access
      Coherent directed movement toward food modeled in Trichoplax, a ciliated animal lacking a nervous system
      Carolyn L. Smith, Thomas S. Reese, Tzipe Govezensky, and Rafael A. Barrio
      PNAS April 30, 2019 116 (18) 8901-8908; first published April 12, 2019. https://doi.org/10.1073/pnas.1815655116
  • Cell Biology

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      Distinct segregation patterns of yeast cell-peripheral proteins uncovered by a method for protein segregatome analysis
      Shinju Sugiyama and Motomasa Tanaka
      PNAS April 30, 2019 116 (18) 8909-8918; first published April 11, 2019. https://doi.org/10.1073/pnas.1819715116
  • Ecology

    • Open Access
      Early tropical crop production in marginal subtropical and temperate Polynesia
      • From the Cover
      Matthew Prebble, Atholl J. Anderson, Paul Augustinus, Joshua Emmitt, Stewart J. Fallon, Louise L. Furey, Simon J. Holdaway, Alex Jorgensen, Thegn N. Ladefoged, Peter J. Matthews, Jean-Yves Meyer, Rebecca Phillipps, Rod Wallace, and Nicholas Porch
      PNAS April 30, 2019 116 (18) 8824-8833; first published April 8, 2019. https://doi.org/10.1073/pnas.1821732116

      See companion article:

      • Reply to Barber: Marginal evidence for taro production in northern New Zealand between 1200 and 1500 CE
        - Jan 14, 2020
    • You have access
      Social alliances improve rank and fitness in convention-based societies
      • From the Cover
      Eli D. Strauss and Kay E. Holekamp
      PNAS April 30, 2019 116 (18) 8919-8924; first published March 11, 2019. https://doi.org/10.1073/pnas.1810384116

      See companion article:

      • Hyena politics: The dynamics of dynasties
        - Mar 25, 2019
    • You have access
      Predators attacking virtual prey reveal the costs and benefits of leadership
      Christos C. Ioannou, Florence Rocque, James E. Herbert-Read, Callum Duffield, and Josh A. Firth
      PNAS April 30, 2019 116 (18) 8925-8930; first published April 15, 2019. https://doi.org/10.1073/pnas.1816323116
  • Environmental Sciences

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      Environmental DNA for improved detection and environmental surveillance of schistosomiasis
      Mita E. Sengupta, Micaela Hellström, Henry C. Kariuki, Annette Olsen, Philip F. Thomsen, Helena Mejer, Eske Willerslev, Mariam T. Mwanje, Henry Madsen, Thomas K. Kristensen, Anna-Sofie Stensgaard, and Birgitte J. Vennervald
      PNAS April 30, 2019 116 (18) 8931-8940; first published April 11, 2019. https://doi.org/10.1073/pnas.1815046116
  • Evolution

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      Evolution of social norms and correlated equilibria
      Bryce Morsky and Erol Akçay
      PNAS April 30, 2019 116 (18) 8834-8839; first published April 11, 2019. https://doi.org/10.1073/pnas.1817095116
    • You have access
      Testing the role of trait reversal in evolutionary diversification using song loss in wild crickets
      Nathan W. Bailey, Sonia Pascoal, and Fernando Montealegre-Z
      PNAS April 30, 2019 116 (18) 8941-8949; first published April 16, 2019. https://doi.org/10.1073/pnas.1818998116
    • Open Access
      Exaggeration and cooption of innate immunity for social defense
      Mayako Kutsukake, Minoru Moriyama, Shuji Shigenobu, Xian-Ying Meng, Naruo Nikoh, Chiyo Noda, Satoru Kobayashi, and Takema Fukatsu
      PNAS April 30, 2019 116 (18) 8950-8959; first published April 15, 2019. https://doi.org/10.1073/pnas.1900917116
  • Genetics

    • Open Access
      Functional characterization of 3D protein structures informed by human genetic diversity
      Michael Hicks, Istvan Bartha, Julia di Iulio, J. Craig Venter, and Amalio Telenti
      PNAS April 30, 2019 116 (18) 8960-8965; first published April 15, 2019. https://doi.org/10.1073/pnas.1820813116
  • Immunology and Inflammation

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      Designer covalent heterobivalent inhibitors prevent IgE-dependent responses to peanut allergen
      • From the Cover
      Peter E. Deak, Baksun Kim, Amina Abdul Qayum, Jaeho Shin, Girish Vitalpur, Kirsten M. Kloepfer, Matthew J. Turner, Neal Smith, Wayne G. Shreffler, Tanyel Kiziltepe, Mark H. Kaplan, and Basar Bilgicer
      PNAS April 30, 2019 116 (18) 8966-8974; first published April 8, 2019. https://doi.org/10.1073/pnas.1820417116
    • You have access
      Hypoxia-inducible factors in CD4+ T cells promote metabolism, switch cytokine secretion, and T cell help in humoral immunity
      Sung Hoon Cho, Ariel L. Raybuck, Julianna Blagih, Edna Kemboi, Volker H. Haase, Russell G. Jones, and Mark R. Boothby
      PNAS April 30, 2019 116 (18) 8975-8984; first published April 15, 2019. https://doi.org/10.1073/pnas.1811702116
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      DNA threads released by activated CD4+ T lymphocytes provide autocrine costimulation
      Massimo Costanza, Pietro L. Poliani, Paola Portararo, Barbara Cappetti, Silvia Musio, Francesca Pagani, Lawrence Steinman, Mario P. Colombo, Rosetta Pedotti, and Sabina Sangaletti
      PNAS April 30, 2019 116 (18) 8985-8994; first published April 15, 2019. https://doi.org/10.1073/pnas.1822013116
    • Open Access
      Select sequencing of clonally expanded CD8+ T cells reveals limits to clonal expansion
      Huang Huang, Michael J. Sikora, Saiful Islam, Roshni Roy Chowdhury, Yueh-hsiu Chien, Thomas J. Scriba, Mark M. Davis, and Lars M. Steinmetz
      PNAS April 30, 2019 116 (18) 8995-9001; first published April 16, 2019. https://doi.org/10.1073/pnas.1902649116
  • Medical Sciences

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      Rapid screening of engineered microbial therapies in a 3D multicellular model
      Tetsuhiro Harimoto, Zakary S. Singer, Oscar S. Velazquez, Joanna Zhang, Samuel Castro, Taylor E. Hinchliffe, William Mather, and Tal Danino
      PNAS April 30, 2019 116 (18) 9002-9007; first published April 17, 2019. https://doi.org/10.1073/pnas.1820824116
    • You have access
      Inherited predisposition to malignant mesothelioma and overall survival following platinum chemotherapy
      Raffit Hassan, Betsy Morrow, Anish Thomas, Tom Walsh, Ming K. Lee, Suleyman Gulsuner, Meghana Gadiraju, Vasiliki Panou, Shaojian Gao, Idrees Mian, Javed Khan, Mark Raffeld, Snehal Patel, Liqiang Xi, Jun S. Wei, Mary Hesdorffer, Jingli Zhang, Kathleen Calzone, Arpita Desai, Emerson Padiernos, Christine Alewine, David S. Schrump, Seth M. Steinberg, Hedy L. Kindler, Mary-Claire King, and Jane E. Churpek
      PNAS April 30, 2019 116 (18) 9008-9013; first published April 11, 2019. https://doi.org/10.1073/pnas.1821510116
    • Open Access
      Single-cell whole-genome sequencing reveals the functional landscape of somatic mutations in B lymphocytes across the human lifespan
      Lei Zhang, Xiao Dong, Moonsook Lee, Alexander Y. Maslov, Tao Wang, and Jan Vijg
      PNAS April 30, 2019 116 (18) 9014-9019; first published April 16, 2019. https://doi.org/10.1073/pnas.1902510116
    • You have access
      Cancer stemness, intratumoral heterogeneity, and immune response across cancers
      Alex Miranda, Phineas T. Hamilton, Allen W. Zhang, Swetansu Pattnaik, Etienne Becht, Artur Mezheyeuski, Jarle Bruun, Patrick Micke, Aurélien de Reynies, and Brad H. Nelson
      PNAS April 30, 2019 116 (18) 9020-9029; first published April 17, 2019. https://doi.org/10.1073/pnas.1818210116
    • Open Access
      Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis
      • From the Cover
      Alexandra M. Nicaise, Laura J. Wagstaff, Cory M. Willis, Carolyn Paisie, Harshpreet Chandok, Paul Robson, Valentina Fossati, Anna Williams, and Stephen J. Crocker
      PNAS April 30, 2019 116 (18) 9030-9039; first published March 25, 2019. https://doi.org/10.1073/pnas.1818348116

      See companion article:

      • New age for progressive multiple sclerosis
        - Apr 19, 2019
  • Microbiology

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      Mutations in the HIV-1 envelope glycoprotein can broadly rescue blocks at multiple steps in the virus replication cycle
      Rachel Van Duyne, Lillian S. Kuo, Phuong Pham, Ken Fujii, and Eric O. Freed
      PNAS April 30, 2019 116 (18) 9040-9049; first published April 11, 2019. https://doi.org/10.1073/pnas.1820333116
  • Neuroscience

    • Open Access
      Functional connectomics of affective and psychotic pathology
      Justin T. Baker, Daniel G. Dillon, Lauren M. Patrick, Joshua L. Roffman, Roscoe O. Brady Jr., Diego A. Pizzagalli, Dost Öngür, and Avram J. Holmes
      PNAS April 30, 2019 116 (18) 9050-9059; first published April 15, 2019. https://doi.org/10.1073/pnas.1820780116
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      Causal inference accounts for heading perception in the presence of object motion
      Kalpana Dokka, Hyeshin Park, Michael Jansen, Gregory C. DeAngelis, and Dora E. Angelaki
      PNAS April 30, 2019 116 (18) 9060-9065; first published April 17, 2019. https://doi.org/10.1073/pnas.1820373116
    • You have access
      Compulsive drug use is associated with imbalance of orbitofrontal- and prelimbic-striatal circuits in punishment-resistant individuals
      Yuzheng Hu, Betty Jo Salmeron, Irina N. Krasnova, Hong Gu, Hanbing Lu, Antonello Bonci, Jean L. Cadet, Elliot A. Stein, and Yihong Yang
      PNAS April 30, 2019 116 (18) 9066-9071; first published April 15, 2019. https://doi.org/10.1073/pnas.1819978116
    • You have access
      Modulation of fear generalization by the zona incerta
      Archana Venkataraman, Natalia Brody, Preethi Reddi, Jidong Guo, Donald Gordon Rainnie, and Brian George Dias
      PNAS April 30, 2019 116 (18) 9072-9077; first published April 9, 2019. https://doi.org/10.1073/pnas.1820541116
    • Open Access
      Reduced default mode network functional connectivity in patients with recurrent major depressive disorder
      Chao-Gan Yan, Xiao Chen, Le Li, Francisco Xavier Castellanos, Tong-Jian Bai, Qi-Jing Bo, Jun Cao, Guan-Mao Chen, Ning-Xuan Chen, Wei Chen, Chang Cheng, Yu-Qi Cheng, Xi-Long Cui, Jia Duan, Yi-Ru Fang, Qi-Yong Gong, Wen-Bin Guo, Zheng-Hua Hou, Lan Hu, Li Kuang, Feng Li, Kai-Ming Li, Tao Li, Yan-Song Liu, Zhe-Ning Liu, Yi-Cheng Long, Qing-Hua Luo, Hua-Qing Meng, Dai-Hui Peng, Hai-Tang Qiu, Jiang Qiu, Yue-Di Shen, Yu-Shu Shi, Chuan-Yue Wang, Fei Wang, Kai Wang, Li Wang, Xiang Wang, Ying Wang, Xiao-Ping Wu, Xin-Ran Wu, Chun-Ming Xie, Guang-Rong Xie, Hai-Yan Xie, Peng Xie, Xiu-Feng Xu, Hong Yang, Jian Yang, Jia-Shu Yao, Shu-Qiao Yao, Ying-Ying Yin, Yong-Gui Yuan, Ai-Xia Zhang, Hong Zhang, Ke-Rang Zhang, Lei Zhang, Zhi-Jun Zhang, Ru-Bai Zhou, Yi-Ting Zhou, Jun-Juan Zhu, Chao-Jie Zou, Tian-Mei Si, Xi-Nian Zuo, Jing-Ping Zhao, and Yu-Feng Zang
      PNAS April 30, 2019 116 (18) 9078-9083; first published April 12, 2019. https://doi.org/10.1073/pnas.1900390116
    • You have access
      Intrinsic planar polarity mechanisms influence the position-dependent regulation of synapse properties in inner hair cells
      Philippe Jean, Özge Demet Özçete, Basile Tarchini, and Tobias Moser
      PNAS April 30, 2019 116 (18) 9084-9093; first published April 11, 2019. https://doi.org/10.1073/pnas.1818358116
    • You have access
      Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer’s disease pathologies
      Jie Xiang, Zhi-Hao Wang, Eun Hee Ahn, Xia Liu, Shan-Ping Yu, Fredric P. Manfredsson, Ivette M. Sandoval, Gong Ju, Shengxi Wu, and Keqiang Ye
      PNAS April 30, 2019 116 (18) 9094-9102; first published April 19, 2019. https://doi.org/10.1073/pnas.1901348116
    • You have access
      Hypoxia tolerance in the Norrin-deficient retina and the chronically hypoxic brain studied at single-cell resolution
      Jacob S. Heng, Amir Rattner, Genevieve L. Stein-O’Brien, Briana L. Winer, Bryan W. Jones, Hilary J. Vernon, Loyal A. Goff, and Jeremy Nathans
      PNAS April 30, 2019 116 (18) 9103-9114; first published April 15, 2019. https://doi.org/10.1073/pnas.1821122116
    • You have access
      Protease-independent action of tissue plasminogen activator in brain plasticity and neurological recovery after ischemic stroke
      Hongjian Pu, Yejie Shi, Lili Zhang, Zhengyu Lu, Qing Ye, Rehana K. Leak, Fei Xu, Shubei Ma, Hongfeng Mu, Zhishuo Wei, Na Xu, Yuguo Xia, Xiaoming Hu, T. Kevin Hitchens, Michael V. L. Bennett, and Jun Chen
      PNAS April 30, 2019 116 (18) 9115-9124; first published April 17, 2019. https://doi.org/10.1073/pnas.1821979116
  • Physiology

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      Constitutive release of CPS1 in bile and its role as a protective cytokine during acute liver injury
      Min-Jung Park, Louis G. D’Alecy, Michelle A. Anderson, Venkatesha Basrur, Yongjia Feng, Graham F. Brady, Dong-il Kim, Jun Wu, Alexey I. Nesvizhskii, Joerg Lahann, Nicholas W. Lukacs, Robert J. Fontana, and M. Bishr Omary
      PNAS April 30, 2019 116 (18) 9125-9134; first published April 12, 2019. https://doi.org/10.1073/pnas.1822173116

Corrections

  • You have access
    Correction for Drollette et al., Elevated levels of diesel range organic compounds in groundwater near Marcellus gas operations are derived from surface activities
    PNAS April 30, 2019 116 (18) 9135; first published April 22, 2019. https://doi.org/10.1073/pnas.1905353116
  • You have access
    Correction for Khoddami et al., Transcriptome-wide profiling of multiple RNA modifications simultaneously at single-base resolution
    PNAS April 30, 2019 116 (18) 9136; first published April 22, 2019. https://doi.org/10.1073/pnas.1905628116
  • You have access
    Correction for Tang and Dubayah, Light-driven growth in Amazon evergreen forests explained by seasonal variations of vertical canopy structure
    PNAS April 30, 2019 116 (18) 9137; first published April 23, 2019. https://doi.org/10.1073/pnas.1905220116
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Proceedings of the National Academy of Sciences: 116 (18)
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