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Research Article

Cancer stemness, intratumoral heterogeneity, and immune response across cancers

Alex Miranda, Phineas T. Hamilton, Allen W. Zhang, Swetansu Pattnaik, Etienne Becht, View ORCID ProfileArtur Mezheyeuski, Jarle Bruun, Patrick Micke, Aurélien de Reynies, and Brad H. Nelson
  1. aDeeley Research Centre, BC Cancer, Victoria, BC V8R 6V5, Canada;
  2. bDepartment of Molecular Oncology, BC Cancer, Vancouver, BC V5Z 4E6, Canada;
  3. cCentre for Molecular Medicine and Therapeutics, BC Children’s Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada;
  4. dGraduate Bioinformatics Training Program, University of British Columbia, Vancouver, BC V6T 1Z3, Canada;
  5. eThe Kinghorn Cancer Centre and Cancer Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia;
  6. fSingapore Immunology Network, Agency for Science, Technology and Research, 138648 Singapore;
  7. gDepartment of Immunology, Genetics, and Pathology, Uppsala University, 751 85 Uppsala, Sweden;
  8. hDepartment of Molecular Oncology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, 0379 Oslo, Norway;
  9. iProgramme Cartes d’Identité des Tumeurs, Ligue Nationale Contre le Cancer, 75013 Paris, France;
  10. jDepartment of Biochemistry and Microbiology, University of Victoria, Victoria, BC V8P 3E6, Canada;
  11. kDepartment of Medical Genetics, University of British Columbia, Vancouver, BC V6T 1Z3, Canada

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PNAS April 30, 2019 116 (18) 9020-9029; first published April 17, 2019; https://doi.org/10.1073/pnas.1818210116
Alex Miranda
aDeeley Research Centre, BC Cancer, Victoria, BC V8R 6V5, Canada;
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Phineas T. Hamilton
aDeeley Research Centre, BC Cancer, Victoria, BC V8R 6V5, Canada;
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Allen W. Zhang
bDepartment of Molecular Oncology, BC Cancer, Vancouver, BC V5Z 4E6, Canada;
cCentre for Molecular Medicine and Therapeutics, BC Children’s Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada;
dGraduate Bioinformatics Training Program, University of British Columbia, Vancouver, BC V6T 1Z3, Canada;
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Swetansu Pattnaik
eThe Kinghorn Cancer Centre and Cancer Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia;
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Etienne Becht
fSingapore Immunology Network, Agency for Science, Technology and Research, 138648 Singapore;
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Artur Mezheyeuski
gDepartment of Immunology, Genetics, and Pathology, Uppsala University, 751 85 Uppsala, Sweden;
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  • ORCID record for Artur Mezheyeuski
Jarle Bruun
hDepartment of Molecular Oncology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, 0379 Oslo, Norway;
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Patrick Micke
gDepartment of Immunology, Genetics, and Pathology, Uppsala University, 751 85 Uppsala, Sweden;
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Aurélien de Reynies
iProgramme Cartes d’Identité des Tumeurs, Ligue Nationale Contre le Cancer, 75013 Paris, France;
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Brad H. Nelson
aDeeley Research Centre, BC Cancer, Victoria, BC V8R 6V5, Canada;
jDepartment of Biochemistry and Microbiology, University of Victoria, Victoria, BC V8P 3E6, Canada;
kDepartment of Medical Genetics, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
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  • For correspondence: bnelson@bccrc.ca
  1. Edited by Douglas Hanahan, Swiss Federal Institute of Technology Lausanne, Lausanne, Switzerland, and approved March 22, 2019 (received for review October 22, 2018)

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Article Information

vol. 116 no. 18 9020-9029
DOI: 
https://doi.org/10.1073/pnas.1818210116
PubMed: 
30996127

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue April 30, 2019.
  • Published first April 17, 2019.

Article Versions

  • Previous version (April 17, 2019 - 11:51).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
© 2019 Published under the PNAS license.

Author Information

  1. Alex Mirandaa,1,
  2. Phineas T. Hamiltona,1,
  3. Allen W. Zhangb,c,d,
  4. Swetansu Pattnaike,
  5. Etienne Bechtf,
  6. Artur Mezheyeuskig,
  7. Jarle Bruunh,
  8. Patrick Mickeg,
  9. Aurélien de Reyniesi, and
  10. Brad H. Nelsona,j,k,2
  1. aDeeley Research Centre, BC Cancer, Victoria, BC V8R 6V5, Canada;
  2. bDepartment of Molecular Oncology, BC Cancer, Vancouver, BC V5Z 4E6, Canada;
  3. cCentre for Molecular Medicine and Therapeutics, BC Children’s Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada;
  4. dGraduate Bioinformatics Training Program, University of British Columbia, Vancouver, BC V6T 1Z3, Canada;
  5. eThe Kinghorn Cancer Centre and Cancer Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia;
  6. fSingapore Immunology Network, Agency for Science, Technology and Research, 138648 Singapore;
  7. gDepartment of Immunology, Genetics, and Pathology, Uppsala University, 751 85 Uppsala, Sweden;
  8. hDepartment of Molecular Oncology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, 0379 Oslo, Norway;
  9. iProgramme Cartes d’Identité des Tumeurs, Ligue Nationale Contre le Cancer, 75013 Paris, France;
  10. jDepartment of Biochemistry and Microbiology, University of Victoria, Victoria, BC V8P 3E6, Canada;
  11. kDepartment of Medical Genetics, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
  1. Edited by Douglas Hanahan, Swiss Federal Institute of Technology Lausanne, Lausanne, Switzerland, and approved March 22, 2019 (received for review October 22, 2018)

Footnotes

  • ↵1A. Miranda. and P.T.H. contributed equally to this work.

  • ↵2To whom correspondence should be addressed. Email: bnelson{at}bccrc.ca.
  • Author contributions: A. Miranda, P.T.H., and B.H.N. designed research; A. Miranda and P.T.H. performed research; E.B., A. Mezheyeuski, J.B., P.M., and A.d.R. contributed new reagents/analytic tools; A. Miranda, P.T.H., A.W.Z., S.P., and B.H.N. analyzed data; B.H.N. conducted study supervision; and A. Miranda, P.T.H., and B.H.N. wrote the paper.

  • The authors declare no conflict of interest.

  • This article is a PNAS Direct Submission.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1818210116/-/DCSupplemental.

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Article usage: April 2019 to March 2021

AbstractFullPdf
Apr 20191932417332
May 20191919539292
Jun 201931917880
Jul 20192107855
Aug 20191807839
Sep 20191747438
Oct 201920311355
Nov 201933319137
Dec 20191531189
Total 2019498521071117
Jan 202030343104
Feb 20202328986
Mar 202030328104
Apr 202031370170
May 202033404182
Jun 202019299104
Jul 20202233899
Aug 202024346104
Sep 202026288137
Oct 20203329962
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Total 202033839661379
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Mar 2021116323
Total 202164695217
Total538767682713
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Cancer stemness, intratumoral heterogeneity, and immune response across cancers
Alex Miranda, Phineas T. Hamilton, Allen W. Zhang, Swetansu Pattnaik, Etienne Becht, Artur Mezheyeuski, Jarle Bruun, Patrick Micke, Aurélien de Reynies, Brad H. Nelson
Proceedings of the National Academy of Sciences Apr 2019, 116 (18) 9020-9029; DOI: 10.1073/pnas.1818210116

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Cancer stemness, intratumoral heterogeneity, and immune response across cancers
Alex Miranda, Phineas T. Hamilton, Allen W. Zhang, Swetansu Pattnaik, Etienne Becht, Artur Mezheyeuski, Jarle Bruun, Patrick Micke, Aurélien de Reynies, Brad H. Nelson
Proceedings of the National Academy of Sciences Apr 2019, 116 (18) 9020-9029; DOI: 10.1073/pnas.1818210116
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