Better explicating the strengths and shortcomings of these models will help refine projections and improve transparency in the years ahead.
Image credit: Witsawat.S.
Edited by Douglas Hanahan, Swiss Federal Institute of Technology Lausanne, Lausanne, Switzerland, and approved March 22, 2019 (received for review October 22, 2018)
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- Published in issue April 30, 2019.
- Published first April 17, 2019.
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- Previous version (April 17, 2019 - 11:51).
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Author Information
- Alex Mirandaa,1,
- Phineas T. Hamiltona,1,
- Allen W. Zhangb,c,d,
- Swetansu Pattnaike,
- Etienne Bechtf,
- Artur Mezheyeuskig,
- Jarle Bruunh,
- Patrick Mickeg,
- Aurélien de Reyniesi, and
- Brad H. Nelsona,j,k,2
- aDeeley Research Centre, BC Cancer, Victoria, BC V8R 6V5, Canada;
- bDepartment of Molecular Oncology, BC Cancer, Vancouver, BC V5Z 4E6, Canada;
- cCentre for Molecular Medicine and Therapeutics, BC Children’s Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada;
- dGraduate Bioinformatics Training Program, University of British Columbia, Vancouver, BC V6T 1Z3, Canada;
- eThe Kinghorn Cancer Centre and Cancer Division, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia;
- fSingapore Immunology Network, Agency for Science, Technology and Research, 138648 Singapore;
- gDepartment of Immunology, Genetics, and Pathology, Uppsala University, 751 85 Uppsala, Sweden;
- hDepartment of Molecular Oncology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, 0379 Oslo, Norway;
- iProgramme Cartes d’Identité des Tumeurs, Ligue Nationale Contre le Cancer, 75013 Paris, France;
- jDepartment of Biochemistry and Microbiology, University of Victoria, Victoria, BC V8P 3E6, Canada;
- kDepartment of Medical Genetics, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
Edited by Douglas Hanahan, Swiss Federal Institute of Technology Lausanne, Lausanne, Switzerland, and approved March 22, 2019 (received for review October 22, 2018)
Footnotes
↵1A. Miranda. and P.T.H. contributed equally to this work.
- ↵2To whom correspondence should be addressed. Email: bnelson{at}bccrc.ca.
Author contributions: A. Miranda, P.T.H., and B.H.N. designed research; A. Miranda and P.T.H. performed research; E.B., A. Mezheyeuski, J.B., P.M., and A.d.R. contributed new reagents/analytic tools; A. Miranda, P.T.H., A.W.Z., S.P., and B.H.N. analyzed data; B.H.N. conducted study supervision; and A. Miranda, P.T.H., and B.H.N. wrote the paper.
The authors declare no conflict of interest.
This article is a PNAS Direct Submission.
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1818210116/-/DCSupplemental.
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