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Research Article

Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis

Soumik BasuRay, Yang Wang, Eriks Smagris, Jonathan C. Cohen, and Helen H. Hobbs
PNAS May 7, 2019 116 (19) 9521-9526; first published April 24, 2019; https://doi.org/10.1073/pnas.1901974116
Soumik BasuRay
aDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390;
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Yang Wang
aDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390;
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Eriks Smagris
aDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390;
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Jonathan C. Cohen
bDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390;
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  • For correspondence: jonathan.cohen@utsouthwestern.edu helen.hobbs@utsouthwestern.edu
Helen H. Hobbs
aDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390;
bDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390;
cHoward Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390
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  • For correspondence: jonathan.cohen@utsouthwestern.edu helen.hobbs@utsouthwestern.edu
  1. Contributed by Helen H. Hobbs, March 19, 2019 (sent for review February 4, 2019; reviewed by Edward A. Fisher and Rudi Zechner)

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Article Information

vol. 116 no. 19 9521-9526
DOI: 
https://doi.org/10.1073/pnas.1901974116
PubMed: 
31019090

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue May 7, 2019.
  • Published first April 24, 2019.

Article Versions

  • Previous version (April 24, 2019 - 11:34).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
Copyright © 2019 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

Author Information

  1. Soumik BasuRaya,
  2. Yang Wanga,
  3. Eriks Smagrisa,
  4. Jonathan C. Cohenb,1, and
  5. Helen H. Hobbsa,b,c,1
  1. aDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390;
  2. bDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390;
  3. cHoward Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390
  1. Contributed by Helen H. Hobbs, March 19, 2019 (sent for review February 4, 2019; reviewed by Edward A. Fisher and Rudi Zechner)

Footnotes

  • ↵1To whom correspondence may be addressed. Email: jonathan.cohen{at}utsouthwestern.edu or helen.hobbs{at}utsouthwestern.edu.
  • Author contributions: S.B.R., Y.W., E.S., J.C.C., and H.H.H. designed research; S.B.R. and Y.W. performed research; S.B.R., Y.W., and E.S. contributed new reagents/analytic tools; S.B.R., Y.W., and H.H.H. analyzed data; and S.B.R., Y.W., E.S., J.C.C., and H.H.H. wrote the paper.

  • Reviewers: E.A.F., New York University School of Medicine; and R.Z., University of Graz.

  • The authors declare no conflicts of interest.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1901974116/-/DCSupplemental.

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Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis
Soumik BasuRay, Yang Wang, Eriks Smagris, Jonathan C. Cohen, Helen H. Hobbs
Proceedings of the National Academy of Sciences May 2019, 116 (19) 9521-9526; DOI: 10.1073/pnas.1901974116

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Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis
Soumik BasuRay, Yang Wang, Eriks Smagris, Jonathan C. Cohen, Helen H. Hobbs
Proceedings of the National Academy of Sciences May 2019, 116 (19) 9521-9526; DOI: 10.1073/pnas.1901974116
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