Table of Contents

Biological Sciences

• Biochemistry

  • Open Access

    Bioactive cell-like hybrids from dendrimersomes with a human cell membrane and its components

    Srujana S. Yadavalli, Qi Xiao, Samuel E. Sherman, William D. Hasley, Michael L. Klein, Mark Goulian, and Virgil Percec

    PNAS January 15, 2019 116 (3) 744-752; first published December 27, 2018. https://doi.org/10.1073/pnas.1811307116
  • Open Access

    Mcm10 has potent strand-annealing activity and limits translocase-mediated fork regression

    Ryan Mayle, Lance Langston, Kelly R. Molloy, Dan Zhang, Brian T. Chait, and Michael E. O’Donnell

    PNAS January 15, 2019 116 (3) 798-803; first published December 31, 2018. https://doi.org/10.1073/pnas.1819107116
  • Open Access

    Structural basis for prodrug recognition by the SLC15 family of proton-coupled peptide transporters

    Gurdeep S. Minhas and Simon Newstead

    PNAS January 15, 2019 116 (3) 804-809; first published January 2, 2019. https://doi.org/10.1073/pnas.1813715116
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    Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification

    Nicole A. Perry, Tamer S. Kaoud, Oscar O. Ortega, Ali I. Kaya, David J. Marcus, John M. Pleinis, Sandra Berndt, Qiuyan Chen, Xuanzhi Zhan, Kevin N. Dalby, Carlos F. Lopez, T. M. Iverson, and Vsevolod V. Gurevich

    PNAS January 15, 2019 116 (3) 810-815; first published December 27, 2018. https://doi.org/10.1073/pnas.1819230116
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    DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells

    Alessio De Magis, Stefano G. Manzo, Marco Russo, Jessica Marinello, Rita Morigi, Olivier Sordet, and Giovanni Capranico

    PNAS January 15, 2019 116 (3) 816-825; first published December 27, 2018. https://doi.org/10.1073/pnas.1810409116
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    ParST is a widespread toxin–antitoxin module that targets nucleotide metabolism

    Frank J. Piscotta, Philip D. Jeffrey, and A. James Link

    PNAS January 15, 2019 116 (3) 826-834; first published December 31, 2018. https://doi.org/10.1073/pnas.1814633116
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    Biosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1-O-methyltransferase specific for 3-O-methylated mannosides

    Jorge Ripoll-Rozada, Mafalda Costa, José A. Manso, Ana Maranha, Vanessa Miranda, André Sequeira, M. Rita Ventura, Sandra Macedo-Ribeiro, Pedro José Barbosa Pereira, and Nuno Empadinhas

    PNAS January 15, 2019 116 (3) 835-844; first published January 3, 2019. https://doi.org/10.1073/pnas.1813450116

• Biophysics and Computational Biology

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    Two symmetric arginine residues play distinct roles in Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage

    Jinping Lei, Gang Sheng, Peter Pak-Hang Cheung, Shenglong Wang, Yu Li, Xin Gao, Yingkai Zhang, Yanli Wang, and Xuhui Huang

    PNAS January 15, 2019 116 (3) 845-853; first published December 27, 2018. https://doi.org/10.1073/pnas.1817041116
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    Role of domain interactions in the aggregation of full-length immunoglobulin light chains

    Enrico Rennella, Gareth J. Morgan, Jeffery W. Kelly, and Lewis E. Kay

    PNAS January 15, 2019 116 (3) 854-863; first published December 31, 2018. https://doi.org/10.1073/pnas.1817538116

• Cell Biology

  • Open Access

    Photoswitching FRET to monitor protein–protein interactions

    Kristin H. Rainey and George H. Patterson

    PNAS January 15, 2019 116 (3) 864-873; first published December 31, 2018. https://doi.org/10.1073/pnas.1805333116
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    Patched1–ArhGAP36–PKA–Inversin axis determines the ciliary translocation of Smoothened for Sonic Hedgehog pathway activation

    Boyan Zhang, Tenghan Zhuang, Qiaoyu Lin, Biying Yang, Xiaowei Xu, Guangwei Xin, Shicong Zhu, Gang Wang, Bin Yu, Tingting Zhang, Qing Jiang, and Chuanmao Zhang

    PNAS January 15, 2019 116 (3) 874-879; first published December 31, 2018. https://doi.org/10.1073/pnas.1804042116
  • Open Access

    Single-molecule imaging of the transcription factor SRF reveals prolonged chromatin-binding kinetics upon cell stimulation

    Lisa Hipp, Judith Beer, Oliver Kuchler, Matthias Reisser, Daniela Sinske, Jens Michaelis, J. Christof M. Gebhardt, and Bernd Knöll

    PNAS January 15, 2019 116 (3) 880-889; first published December 31, 2018. https://doi.org/10.1073/pnas.1812734116
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    Different roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesis

    Na Liu, Junhong Song, Yangyang Xie, Xiao-Lin Wang, Bowen Rong, Na Man, Meng-Meng Zhang, Qunling Zhang, Fei-Fei Gao, Mei-Rong Du, Ying Zhang, Jian Shen, Chun-Hui Xu, Cheng-Long Hu, Ji-Chuan Wu, Ping Liu, Yuan-Liang Zhang, Yin-Yin Xie, Ping Liu, Jin-Yan Huang, Qiu-Hua Huang, Fei Lan, Shuhong Shen, Stephen D. Nimer, Zhu Chen, Sai-Juan Chen, Robert G. Roeder, Lan Wang, and Xiao-Jian Sun

    PNAS January 15, 2019 116 (3) 890-899; first published December 28, 2018. https://doi.org/10.1073/pnas.1809327116

• Developmental Biology

  • Open Access

    Exploiting regulatory heterogeneity to systematically identify enhancers with high accuracy

    Hamutal Arbel, Sumanta Basu, William W. Fisher, Ann S. Hammonds, Kenneth H. Wan, Soo Park, Richard Weiszmann, Benjamin W. Booth, Soile V. Keranen, Clara Henriquez, Omid Shams Solari, Peter J. Bickel, Mark D. Biggin, Susan E. Celniker, and James B. Brown

    PNAS January 15, 2019 116 (3) 900-908; first published December 31, 2018. https://doi.org/10.1073/pnas.1808833115

• Ecology

  • Open Access

    Global synthesis of conservation studies reveals the importance of small habitat patches for biodiversity

    • From the Cover

    Brendan A. Wintle, Heini Kujala, Amy Whitehead, Alison Cameron, Sam Veloz, Aija Kukkala, Atte Moilanen, Ascelin Gordon, Pia E. Lentini, Natasha C. R. Cadenhead, and Sarah A. Bekessy

    PNAS January 15, 2019 116 (3) 909-914; first published December 10, 2018. https://doi.org/10.1073/pnas.1813051115

    See companion article:

    • Small patches make critical contributions to biodiversity conservation

      - Dec 27, 2018
  • Open Access

    Global-scale dispersal and connectivity in mangroves

    • From the Cover

    Tom Van der Stocken, Dustin Carroll, Dimitris Menemenlis, Marc Simard, and Nico Koedam

    PNAS January 15, 2019 116 (3) 915-922; first published December 31, 2018. https://doi.org/10.1073/pnas.1812470116

• Evolution

  • Open Access

    The genomic basis of Red Queen dynamics during rapid reciprocal host–pathogen coevolution

    Andrei Papkou, Thiago Guzella, Wentao Yang, Svenja Koepper, Barbara Pees, Rebecca Schalkowski, Mike-Christoph Barg, Philip C. Rosenstiel, Henrique Teotónio, and Hinrich Schulenburg

    PNAS January 15, 2019 116 (3) 923-928; first published December 31, 2018. https://doi.org/10.1073/pnas.1810402116
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    Climate-induced phenological shifts in a Batesian mimicry complex

    • From the Cover

    Christopher Hassall, Jac Billington, and Thomas N. Sherratt

    PNAS January 15, 2019 116 (3) 929-933; first published December 3, 2018. https://doi.org/10.1073/pnas.1813367115

    See companion article:

    • Creative citizen science illuminates complex ecological responses to climate change

      - Jan 04, 2019
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    Novel genetic code and record-setting AT-richness in the highly reduced plastid genome of the holoparasitic plant Balanophora

    Huei-Jiun Su, Todd J. Barkman, Weilong Hao, Samuel S. Jones, Julia Naumann, Elizabeth Skippington, Eric K. Wafula, Jer-Ming Hu, Jeffrey D. Palmer, and Claude W. dePamphilis

    PNAS January 15, 2019 116 (3) 934-943; first published December 31, 2018. https://doi.org/10.1073/pnas.1816822116

• Genetics

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    HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control

    Jatin Arora, Paul J. McLaren, Nimisha Chaturvedi, Mary Carrington, Jacques Fellay, and Tobias L. Lenz

    PNAS January 15, 2019 116 (3) 944-949; first published January 2, 2019. https://doi.org/10.1073/pnas.1812548116
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    Blacklisting variants common in private cohorts but not in public databases optimizes human exome analysis

    Patrick Maffucci, Benedetta Bigio, Franck Rapaport, Aurélie Cobat, Alessandro Borghesi, Marie Lopez, Etienne Patin, Alexandre Bolze, Lei Shang, Matthieu Bendavid, Eric M. Scott, Peter D. Stenson, Charlotte Cunningham-Rundles, David N. Cooper, Joseph G. Gleeson, Jacques Fellay, Lluis Quintana-Murci, Jean-Laurent Casanova, Laurent Abel, Bertrand Boisson, and Yuval Itan

    PNAS January 15, 2019 116 (3) 950-959; first published December 27, 2018. https://doi.org/10.1073/pnas.1808403116
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    Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo

    Neeraj K. Aryal, Vinod Pant, Amanda R. Wasylishen, Jan Parker-Thornburg, Laura Baseler, Adel K. El-Naggar, Bin Liu, Awdhesh Kalia, Guillermina Lozano, and Swathi Arur

    PNAS January 15, 2019 116 (3) 960-969; first published December 28, 2018. https://doi.org/10.1073/pnas.1814377116

• Immunology and Inflammation

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    Human RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseases

    Yue Li, Marita Führer, Ehsan Bahrami, Piotr Socha, Maja Klaudel-Dreszler, Amira Bouzidi, Yanshan Liu, Anna S. Lehle, Thomas Magg, Sebastian Hollizeck, Meino Rohlfs, Raffaele Conca, Michael Field, Neil Warner, Slae Mordechai, Eyal Shteyer, Dan Turner, Rachida Boukari, Reda Belbouab, Christoph Walz, Moritz M. Gaidt, Veit Hornung, Bernd Baumann, Ulrich Pannicke, Eman Al Idrissi, Hamza Ali Alghamdi, Fernando E. Sepulveda, Marine Gil, Geneviève de Saint Basile, Manfred Hönig, Sibylle Koletzko, Aleixo M. Muise, Scott B. Snapper, Klaus Schwarz, Christoph Klein, and Daniel Kotlarz

    PNAS January 15, 2019 116 (3) 970-975; first published December 27, 2018. https://doi.org/10.1073/pnas.1813582116
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    RNA-binding protein YTHDF3 suppresses interferon-dependent antiviral responses by promoting FOXO3 translation

    Yuan Zhang, Xin Wang, Xiao Zhang, Jiaming Wang, Yuanwu Ma, Lianfeng Zhang, and Xuetao Cao

    PNAS January 15, 2019 116 (3) 976-981; first published December 27, 2018. https://doi.org/10.1073/pnas.1812536116
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    Phosphatase PP2A is essential for T_H17 differentiation

    Qin Xu, Xuexiao Jin, Mingzhu Zheng, Deepak Rohila, Guotong Fu, Zhuoyu Wen, Jun Lou, Songquan Wu, Richard Sloan, Lie Wang, Hu Hu, Xiang Gao, and Linrong Lu

    PNAS January 15, 2019 116 (3) 982-987; first published December 28, 2018. https://doi.org/10.1073/pnas.1807484116
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    Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5

    Han Wang, Jianxun Qi, Shuijun Zhang, Yan Li, Shuguang Tan, and George F. Gao

    PNAS January 15, 2019 116 (3) 988-996; first published December 27, 2018. https://doi.org/10.1073/pnas.1815716116
  • Open Access

    Microglia are effector cells of CD47-SIRPα antiphagocytic axis disruption against glioblastoma

    Gregor Hutter, Johanna Theruvath, Claus Moritz Graef, Michael Zhang, Matthew Kenneth Schoen, Eva Maria Manz, Mariko L. Bennett, Andrew Olson, Tej D. Azad, Rahul Sinha, Carmel Chan, Suzana Assad Kahn, Sharareh Gholamin, Christy Wilson, Gerald Grant, Joy He, Irving L. Weissman, Siddhartha S. Mitra, and Samuel H. Cheshier

    PNAS January 15, 2019 116 (3) 997-1006; first published January 2, 2019. https://doi.org/10.1073/pnas.1721434116
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    Unregulated antigen-presenting cell activation by T cells breaks self tolerance

    Jaeu Yi, Jisun Jung, Sung-Wook Hong, Jun Young Lee, Daehee Han, Kwang Soon Kim, Jonathan Sprent, and Charles D. Surh

    PNAS January 15, 2019 116 (3) 1007-1016; first published December 31, 2018. https://doi.org/10.1073/pnas.1818624116

• Medical Sciences

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    Interfacial fluid transport is a key to hydrogel bioadhesion

    Raphaël Michel, Léna Poirier, Quentin van Poelvoorde, Josette Legagneux, Mathieu Manassero, and Laurent Corté

    PNAS January 15, 2019 116 (3) 738-743; first published January 2, 2019. https://doi.org/10.1073/pnas.1813208116

• Microbiology

  • Open Access

    Rigidification of the Escherichia coli cytoplasm by the human antimicrobial peptide LL-37 revealed by superresolution fluorescence microscopy

    Yanyu Zhu, Sonisilpa Mohapatra, and James C. Weisshaar

    PNAS January 15, 2019 116 (3) 1017-1026; first published December 31, 2018. https://doi.org/10.1073/pnas.1814924116
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    Dual inhibition of MDM2 and MDM4 in virus-positive Merkel cell carcinoma enhances the p53 response

    Donglim Esther Park, Jingwei Cheng, Christian Berrios, Joan Montero, Marta Cortés-Cros, Stéphane Ferretti, Reety Arora, Michelle L. Tillgren, Prafulla C. Gokhale, and James A. DeCaprio

    PNAS January 15, 2019 116 (3) 1027-1032; first published December 31, 2018. https://doi.org/10.1073/pnas.1818798116
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    Herpes simplex virus 1 ICP8 mutant lacking annealing activity is deficient for viral DNA replication

    Savithri Weerasooriya, Katherine A. DiScipio, Anthar S. Darwish, Ping Bai, and Sandra K. Weller

    PNAS January 15, 2019 116 (3) 1033-1042; first published December 31, 2018. https://doi.org/10.1073/pnas.1817642116
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    Regulation of acetate metabolism and coordination with the TCA cycle via a processed small RNA

    François De Mets, Laurence Van Melderen, and Susan Gottesman

    PNAS January 15, 2019 116 (3) 1043-1052; first published December 27, 2018. https://doi.org/10.1073/pnas.1815288116

• Neuroscience

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    Ca²⁺-activated Cl⁻ current ensures robust and reliable signal amplification in vertebrate olfactory receptor neurons

    Johannes Reisert and Jürgen Reingruber

    PNAS January 15, 2019 116 (3) 1053-1058; first published December 31, 2018. https://doi.org/10.1073/pnas.1816371116
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    Conotoxin κM-RIIIJ, a tool targeting asymmetric heteromeric K_v1 channels

    Sönke Cordeiro, Rocio K. Finol-Urdaneta, David Köpfer, Anna Markushina, Jie Song, Robert J. French, Wojciech Kopec, Bert L. de Groot, Mario J. Giacobassi, Lee S. Leavitt, Shrinivasan Raghuraman, Russell W. Teichert, Baldomero M. Olivera, and Heinrich Terlau

    PNAS January 15, 2019 116 (3) 1059-1064; first published December 28, 2018. https://doi.org/10.1073/pnas.1813161116