New Research In
Physical Sciences
Social Sciences
Featured Portals
Articles by Topic
Biological Sciences
Featured Portals
Articles by Topic
- Agricultural Sciences
- Anthropology
- Applied Biological Sciences
- Biochemistry
- Biophysics and Computational Biology
- Cell Biology
- Developmental Biology
- Ecology
- Environmental Sciences
- Evolution
- Genetics
- Immunology and Inflammation
- Medical Sciences
- Microbiology
- Neuroscience
- Pharmacology
- Physiology
- Plant Biology
- Population Biology
- Psychological and Cognitive Sciences
- Sustainability Science
- Systems Biology
Table of Contents
January 15, 2019; vol. 116 no. 3
This Week in PNAS
Editorial
- You have accessProceedings of the National Academy of Sciences—Its evolution and adaptationMay R. BerenbaumPNAS January 15, 2019 116 (3) 704-706; published ahead of print January 7, 2019. https://doi.org/10.1073/pnas.1821201116
Science and Culture
How science intersects with culture.
- You have accessScience and Culture: Searching for the science behind art therapy
- Front Matter
Carolyn Beans
Inner Workings
An over-the-shoulder look at scientists at work.
- You have accessInner Workings: How bacteria could help recycle electronic waste
- Front Matter
Roberta Kwok
Perspective
- Open AccessNutrition, the visceral immune system, and the evolutionary origins of pathogenic obesityMary Jane West-EberhardPNAS January 15, 2019 116 (3) 723-731; published ahead of print December 31, 2018. https://doi.org/10.1073/pnas.1809046116
Physical Sciences
Applied Mathematics
- You have accessLinear variational principle for Riemann mappings and discrete conformalityNadav Dym, Raz Slutsky, and Yaron LipmanPNAS January 15, 2019 116 (3) 732-737; published ahead of print December 28, 2018. https://doi.org/10.1073/pnas.1809731116
Applied Physical Sciences
- You have accessInterfacial fluid transport is a key to hydrogel bioadhesionRaphaël Michel, Léna Poirier, Quentin van Poelvoorde, Josette Legagneux, Mathieu Manassero, and Laurent CortéPNAS January 15, 2019 116 (3) 738-743; published ahead of print January 2, 2019. https://doi.org/10.1073/pnas.1813208116
Biophysics and Computational Biology
- Open AccessPhotoswitching FRET to monitor protein–protein interactionsKristin H. Rainey and George H. PattersonPNAS January 15, 2019 116 (3) 864-873; published ahead of print December 31, 2018. https://doi.org/10.1073/pnas.1805333116
- Open AccessRigidification of the Escherichia coli cytoplasm by the human antimicrobial peptide LL-37 revealed by superresolution fluorescence microscopyYanyu Zhu, Sonisilpa Mohapatra, and James C. WeisshaarPNAS January 15, 2019 116 (3) 1017-1026; published ahead of print December 31, 2018. https://doi.org/10.1073/pnas.1814924116
- You have accessCa2+-activated Cl− current ensures robust and reliable signal amplification in vertebrate olfactory receptor neuronsJohannes Reisert and Jürgen ReingruberPNAS January 15, 2019 116 (3) 1053-1058; published ahead of print December 31, 2018. https://doi.org/10.1073/pnas.1816371116
Chemistry
- Open AccessBioactive cell-like hybrids from dendrimersomes with a human cell membrane and its componentsSrujana S. Yadavalli, Qi Xiao, Samuel E. Sherman, William D. Hasley, Michael L. Klein, Mark Goulian, and Virgil PercecPNAS January 15, 2019 116 (3) 744-752; published ahead of print December 27, 2018. https://doi.org/10.1073/pnas.1811307116
- Open AccessMcm10 has potent strand-annealing activity and limits translocase-mediated fork regressionRyan Mayle, Lance Langston, Kelly R. Molloy, Dan Zhang, Brian T. Chait, and Michael E. O’DonnellPNAS January 15, 2019 116 (3) 798-803; published ahead of print December 31, 2018. https://doi.org/10.1073/pnas.1819107116
Earth, Atmospheric, and Planetary Sciences
- You have accessNanoscale infrared imaging analysis of carbonaceous chondrites to understand organic-mineral interactions during aqueous alterationYoko Kebukawa, Hanae Kobayashi, Norio Urayama, Naoki Baden, Masashi Kondo, Michael E. Zolensky, and Kensei KobayashiPNAS January 15, 2019 116 (3) 753-758; published ahead of print January 2, 2019. https://doi.org/10.1073/pnas.1816265116
Environmental Sciences
- Open AccessEconomic carbon cycle feedbacks may offset additional warming from natural feedbacks
- From the Cover
Dawn L. Woodard, Steven J. Davis, and James T. RandersonPNAS January 15, 2019 116 (3) 759-764; published ahead of print December 17, 2018. https://doi.org/10.1073/pnas.1805187115
Physics
- You have accessDirect electrochemical generation of supercooled sulfur microdroplets well below their melting temperatureNian Liu, Guangmin Zhou, Ankun Yang, Xiaoyun Yu, Feifei Shi, Jie Sun, Jinsong Zhang, Bofei Liu, Chun-Lan Wu, Xinyong Tao, Yongming Sun, Yi Cui, and Steven ChuPNAS January 15, 2019 116 (3) 765-770; published ahead of print January 2, 2019. https://doi.org/10.1073/pnas.1817286116
- Open AccessThermal disequilibration of ions and electrons by collisionless plasma turbulenceYohei Kawazura, Michael Barnes, and Alexander A. SchekochihinPNAS January 15, 2019 116 (3) 771-776; published ahead of print December 31, 2018. https://doi.org/10.1073/pnas.1812491116
- You have accessData-driven quantitative modeling of bacterial active nematicsHe Li, Xia-qing Shi, Mingji Huang, Xiao Chen, Minfeng Xiao, Chenli Liu, Hugues Chaté, and H. P. ZhangPNAS January 15, 2019 116 (3) 777-785; published ahead of print December 28, 2018. https://doi.org/10.1073/pnas.1812570116
Social Sciences
Economic Sciences
- You have accessDesigning combinatorial exchanges for the reallocation of resource rightsMartin Bichler, Vladimir Fux, and Jacob K. GoereePNAS January 15, 2019 116 (3) 786-791; published ahead of print December 31, 2018. https://doi.org/10.1073/pnas.1802123116
Social Sciences
- Open AccessIntegration in emerging social networks explains academic failure and success
- From the Cover
Christoph Stadtfeld, András Vörös, Timon Elmer, Zsófia Boda, and Isabel J. RaabePNAS January 15, 2019 116 (3) 792-797; published ahead of print December 24, 2018. https://doi.org/10.1073/pnas.1811388115
Biological Sciences
Biochemistry
- Open AccessBioactive cell-like hybrids from dendrimersomes with a human cell membrane and its componentsSrujana S. Yadavalli, Qi Xiao, Samuel E. Sherman, William D. Hasley, Michael L. Klein, Mark Goulian, and Virgil PercecPNAS January 15, 2019 116 (3) 744-752; published ahead of print December 27, 2018. https://doi.org/10.1073/pnas.1811307116
- Open AccessMcm10 has potent strand-annealing activity and limits translocase-mediated fork regressionRyan Mayle, Lance Langston, Kelly R. Molloy, Dan Zhang, Brian T. Chait, and Michael E. O’DonnellPNAS January 15, 2019 116 (3) 798-803; published ahead of print December 31, 2018. https://doi.org/10.1073/pnas.1819107116
- Open AccessStructural basis for prodrug recognition by the SLC15 family of proton-coupled peptide transportersGurdeep S. Minhas and Simon NewsteadPNAS January 15, 2019 116 (3) 804-809; published ahead of print January 2, 2019. https://doi.org/10.1073/pnas.1813715116
- You have accessArrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplificationNicole A. Perry, Tamer S. Kaoud, Oscar O. Ortega, Ali I. Kaya, David J. Marcus, John M. Pleinis, Sandra Berndt, Qiuyan Chen, Xuanzhi Zhan, Kevin N. Dalby, Carlos F. Lopez, T. M. Iverson, and Vsevolod V. GurevichPNAS January 15, 2019 116 (3) 810-815; published ahead of print December 27, 2018. https://doi.org/10.1073/pnas.1819230116
- You have accessDNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cellsAlessio De Magis, Stefano G. Manzo, Marco Russo, Jessica Marinello, Rita Morigi, Olivier Sordet, and Giovanni CapranicoPNAS January 15, 2019 116 (3) 816-825; published ahead of print December 27, 2018. https://doi.org/10.1073/pnas.1810409116
- You have accessParST is a widespread toxin–antitoxin module that targets nucleotide metabolismFrank J. Piscotta, Philip D. Jeffrey, and A. James LinkPNAS January 15, 2019 116 (3) 826-834; published ahead of print December 31, 2018. https://doi.org/10.1073/pnas.1814633116
- You have accessBiosynthesis of mycobacterial methylmannose polysaccharides requires a unique 1-O-methyltransferase specific for 3-O-methylated mannosidesJorge Ripoll-Rozada, Mafalda Costa, José A. Manso, Ana Maranha, Vanessa Miranda, André Sequeira, M. Rita Ventura, Sandra Macedo-Ribeiro, Pedro José Barbosa Pereira, and Nuno EmpadinhasPNAS January 15, 2019 116 (3) 835-844; published ahead of print January 3, 2019. https://doi.org/10.1073/pnas.1813450116
Biophysics and Computational Biology
- You have accessTwo symmetric arginine residues play distinct roles in Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavageJinping Lei, Gang Sheng, Peter Pak-Hang Cheung, Shenglong Wang, Yu Li, Xin Gao, Yingkai Zhang, Yanli Wang, and Xuhui HuangPNAS January 15, 2019 116 (3) 845-853; published ahead of print December 27, 2018. https://doi.org/10.1073/pnas.1817041116
- You have accessRole of domain interactions in the aggregation of full-length immunoglobulin light chainsEnrico Rennella, Gareth J. Morgan, Jeffery W. Kelly, and Lewis E. KayPNAS January 15, 2019 116 (3) 854-863; published ahead of print December 31, 2018. https://doi.org/10.1073/pnas.1817538116
Cell Biology
- Open AccessPhotoswitching FRET to monitor protein–protein interactionsKristin H. Rainey and George H. PattersonPNAS January 15, 2019 116 (3) 864-873; published ahead of print December 31, 2018. https://doi.org/10.1073/pnas.1805333116
- You have accessPatched1–ArhGAP36–PKA–Inversin axis determines the ciliary translocation of Smoothened for Sonic Hedgehog pathway activationBoyan Zhang, Tenghan Zhuang, Qiaoyu Lin, Biying Yang, Xiaowei Xu, Guangwei Xin, Shicong Zhu, Gang Wang, Bin Yu, Tingting Zhang, Qing Jiang, and Chuanmao ZhangPNAS January 15, 2019 116 (3) 874-879; published ahead of print December 31, 2018. https://doi.org/10.1073/pnas.1804042116
- Open AccessSingle-molecule imaging of the transcription factor SRF reveals prolonged chromatin-binding kinetics upon cell stimulationLisa Hipp, Judith Beer, Oliver Kuchler, Matthias Reisser, Daniela Sinske, Jens Michaelis, J. Christof M. Gebhardt, and Bernd KnöllPNAS January 15, 2019 116 (3) 880-889; published ahead of print December 31, 2018. https://doi.org/10.1073/pnas.1812734116
- You have accessDifferent roles of E proteins in t(8;21) leukemia: E2-2 compromises the function of AETFC and negatively regulates leukemogenesisNa Liu, Junhong Song, Yangyang Xie, Xiao-Lin Wang, Bowen Rong, Na Man, Meng-Meng Zhang, Qunling Zhang, Fei-Fei Gao, Mei-Rong Du, Ying Zhang, Jian Shen, Chun-Hui Xu, Cheng-Long Hu, Ji-Chuan Wu, Ping Liu, Yuan-Liang Zhang, Yin-Yin Xie, Ping Liu, Jin-Yan Huang, Qiu-Hua Huang, Fei Lan, Shuhong Shen, Stephen D. Nimer, Zhu Chen, Sai-Juan Chen, Robert G. Roeder, Lan Wang, and Xiao-Jian SunPNAS January 15, 2019 116 (3) 890-899; published ahead of print December 28, 2018. https://doi.org/10.1073/pnas.1809327116
Developmental Biology
- Open AccessExploiting regulatory heterogeneity to systematically identify enhancers with high accuracyHamutal Arbel, Sumanta Basu, William W. Fisher, Ann S. Hammonds, Kenneth H. Wan, Soo Park, Richard Weiszmann, Benjamin W. Booth, Soile V. Keranen, Clara Henriquez, Omid Shams Solari, Peter J. Bickel, Mark D. Biggin, Susan E. Celniker, and James B. BrownPNAS January 15, 2019 116 (3) 900-908; published ahead of print December 31, 2018. https://doi.org/10.1073/pnas.1808833115
Ecology
- Open AccessGlobal synthesis of conservation studies reveals the importance of small habitat patches for biodiversity
- From the Cover
Brendan A. Wintle, Heini Kujala, Amy Whitehead, Alison Cameron, Sam Veloz, Aija Kukkala, Atte Moilanen, Ascelin Gordon, Pia E. Lentini, Natasha C. R. Cadenhead, and Sarah A. BekessyPNAS January 15, 2019 116 (3) 909-914; published ahead of print December 10, 2018. https://doi.org/10.1073/pnas.1813051115 - Open AccessGlobal-scale dispersal and connectivity in mangroves
- From the Cover
Tom Van der Stocken, Dustin Carroll, Dimitris Menemenlis, Marc Simard, and Nico KoedamPNAS January 15, 2019 116 (3) 915-922; published ahead of print December 31, 2018. https://doi.org/10.1073/pnas.1812470116
Evolution
- Open AccessThe genomic basis of Red Queen dynamics during rapid reciprocal host–pathogen coevolutionAndrei Papkou, Thiago Guzella, Wentao Yang, Svenja Koepper, Barbara Pees, Rebecca Schalkowski, Mike-Christoph Barg, Philip C. Rosenstiel, Henrique Teotónio, and Hinrich SchulenburgPNAS January 15, 2019 116 (3) 923-928; published ahead of print December 31, 2018. https://doi.org/10.1073/pnas.1810402116
- You have accessClimate-induced phenological shifts in a Batesian mimicry complex
- From the Cover
Christopher Hassall, Jac Billington, and Thomas N. SherrattPNAS January 15, 2019 116 (3) 929-933; published ahead of print December 3, 2018. https://doi.org/10.1073/pnas.1813367115 - You have accessNovel genetic code and record-setting AT-richness in the highly reduced plastid genome of the holoparasitic plant BalanophoraHuei-Jiun Su, Todd J. Barkman, Weilong Hao, Samuel S. Jones, Julia Naumann, Elizabeth Skippington, Eric K. Wafula, Jer-Ming Hu, Jeffrey D. Palmer, and Claude W. dePamphilisPNAS January 15, 2019 116 (3) 934-943; published ahead of print December 31, 2018. https://doi.org/10.1073/pnas.1816822116
Genetics
- You have accessHIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV controlJatin Arora, Paul J. McLaren, Nimisha Chaturvedi, Mary Carrington, Jacques Fellay, and Tobias L. LenzPNAS January 15, 2019 116 (3) 944-949; published ahead of print January 2, 2019. https://doi.org/10.1073/pnas.1812548116
- You have accessBlacklisting variants common in private cohorts but not in public databases optimizes human exome analysisPatrick Maffucci, Benedetta Bigio, Franck Rapaport, Aurélie Cobat, Alessandro Borghesi, Marie Lopez, Etienne Patin, Alexandre Bolze, Lei Shang, Matthieu Bendavid, Eric M. Scott, Peter D. Stenson, Charlotte Cunningham-Rundles, David N. Cooper, Joseph G. Gleeson, Jacques Fellay, Lluis Quintana-Murci, Jean-Laurent Casanova, Laurent Abel, Bertrand Boisson, and Yuval ItanPNAS January 15, 2019 116 (3) 950-959; published ahead of print December 27, 2018. https://doi.org/10.1073/pnas.1808403116
- You have accessConstitutive Dicer1 phosphorylation accelerates metabolism and aging in vivoNeeraj K. Aryal, Vinod Pant, Amanda R. Wasylishen, Jan Parker-Thornburg, Laura Baseler, Adel K. El-Naggar, Bin Liu, Awdhesh Kalia, Guillermina Lozano, and Swathi ArurPNAS January 15, 2019 116 (3) 960-969; published ahead of print December 28, 2018. https://doi.org/10.1073/pnas.1814377116
Immunology and Inflammation
- You have accessHuman RIPK1 deficiency causes combined immunodeficiency and inflammatory bowel diseasesYue Li, Marita Führer, Ehsan Bahrami, Piotr Socha, Maja Klaudel-Dreszler, Amira Bouzidi, Yanshan Liu, Anna S. Lehle, Thomas Magg, Sebastian Hollizeck, Meino Rohlfs, Raffaele Conca, Michael Field, Neil Warner, Slae Mordechai, Eyal Shteyer, Dan Turner, Rachida Boukari, Reda Belbouab, Christoph Walz, Moritz M. Gaidt, Veit Hornung, Bernd Baumann, Ulrich Pannicke, Eman Al Idrissi, Hamza Ali Alghamdi, Fernando E. Sepulveda, Marine Gil, Geneviève de Saint Basile, Manfred Hönig, Sibylle Koletzko, Aleixo M. Muise, Scott B. Snapper, Klaus Schwarz, Christoph Klein, and Daniel KotlarzPNAS January 15, 2019 116 (3) 970-975; published ahead of print December 27, 2018. https://doi.org/10.1073/pnas.1813582116
- You have accessRNA-binding protein YTHDF3 suppresses interferon-dependent antiviral responses by promoting FOXO3 translationYuan Zhang, Xin Wang, Xiao Zhang, Jiaming Wang, Yuanwu Ma, Lianfeng Zhang, and Xuetao CaoPNAS January 15, 2019 116 (3) 976-981; published ahead of print December 27, 2018. https://doi.org/10.1073/pnas.1812536116
- You have accessPhosphatase PP2A is essential for TH17 differentiationQin Xu, Xuexiao Jin, Mingzhu Zheng, Deepak Rohila, Guotong Fu, Zhuoyu Wen, Jun Lou, Songquan Wu, Richard Sloan, Lie Wang, Hu Hu, Xiang Gao, and Linrong LuPNAS January 15, 2019 116 (3) 982-987; published ahead of print December 28, 2018. https://doi.org/10.1073/pnas.1807484116
- You have accessBinding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5Han Wang, Jianxun Qi, Shuijun Zhang, Yan Li, Shuguang Tan, and George F. GaoPNAS January 15, 2019 116 (3) 988-996; published ahead of print December 27, 2018. https://doi.org/10.1073/pnas.1815716116
- Open AccessMicroglia are effector cells of CD47-SIRPα antiphagocytic axis disruption against glioblastomaGregor Hutter, Johanna Theruvath, Claus Moritz Graef, Michael Zhang, Matthew Kenneth Schoen, Eva Maria Manz, Mariko L. Bennett, Andrew Olson, Tej D. Azad, Rahul Sinha, Carmel Chan, Suzana Assad Kahn, Sharareh Gholamin, Christy Wilson, Gerald Grant, Joy He, Irving L. Weissman, Siddhartha S. Mitra, and Samuel H. CheshierPNAS January 15, 2019 116 (3) 997-1006; published ahead of print January 2, 2019. https://doi.org/10.1073/pnas.1721434116
- You have accessUnregulated antigen-presenting cell activation by T cells breaks self toleranceJaeu Yi, Jisun Jung, Sung-Wook Hong, Jun Young Lee, Daehee Han, Kwang Soon Kim, Jonathan Sprent, and Charles D. SurhPNAS January 15, 2019 116 (3) 1007-1016; published ahead of print December 31, 2018. https://doi.org/10.1073/pnas.1818624116
Medical Sciences
- You have accessInterfacial fluid transport is a key to hydrogel bioadhesionRaphaël Michel, Léna Poirier, Quentin van Poelvoorde, Josette Legagneux, Mathieu Manassero, and Laurent CortéPNAS January 15, 2019 116 (3) 738-743; published ahead of print January 2, 2019. https://doi.org/10.1073/pnas.1813208116
Microbiology
- Open AccessRigidification of the Escherichia coli cytoplasm by the human antimicrobial peptide LL-37 revealed by superresolution fluorescence microscopyYanyu Zhu, Sonisilpa Mohapatra, and James C. WeisshaarPNAS January 15, 2019 116 (3) 1017-1026; published ahead of print December 31, 2018. https://doi.org/10.1073/pnas.1814924116
- You have accessDual inhibition of MDM2 and MDM4 in virus-positive Merkel cell carcinoma enhances the p53 responseDonglim Esther Park, Jingwei Cheng, Christian Berrios, Joan Montero, Marta Cortés-Cros, Stéphane Ferretti, Reety Arora, Michelle L. Tillgren, Prafulla C. Gokhale, and James A. DeCaprioPNAS January 15, 2019 116 (3) 1027-1032; published ahead of print December 31, 2018. https://doi.org/10.1073/pnas.1818798116
- You have accessHerpes simplex virus 1 ICP8 mutant lacking annealing activity is deficient for viral DNA replicationSavithri Weerasooriya, Katherine A. DiScipio, Anthar S. Darwish, Ping Bai, and Sandra K. WellerPNAS January 15, 2019 116 (3) 1033-1042; published ahead of print December 31, 2018. https://doi.org/10.1073/pnas.1817642116
- You have accessRegulation of acetate metabolism and coordination with the TCA cycle via a processed small RNAFrançois De Mets, Laurence Van Melderen, and Susan GottesmanPNAS January 15, 2019 116 (3) 1043-1052; published ahead of print December 27, 2018. https://doi.org/10.1073/pnas.1815288116
Neuroscience
- You have accessCa2+-activated Cl− current ensures robust and reliable signal amplification in vertebrate olfactory receptor neuronsJohannes Reisert and Jürgen ReingruberPNAS January 15, 2019 116 (3) 1053-1058; published ahead of print December 31, 2018. https://doi.org/10.1073/pnas.1816371116
- You have accessConotoxin κM-RIIIJ, a tool targeting asymmetric heteromeric Kv1 channelsSönke Cordeiro, Rocio K. Finol-Urdaneta, David Köpfer, Anna Markushina, Jie Song, Robert J. French, Wojciech Kopec, Bert L. de Groot, Mario J. Giacobassi, Lee S. Leavitt, Shrinivasan Raghuraman, Russell W. Teichert, Baldomero M. Olivera, and Heinrich TerlauPNAS January 15, 2019 116 (3) 1059-1064; published ahead of print December 28, 2018. https://doi.org/10.1073/pnas.1813161116
Corrections
- You have accessCorrection for Li et al., Pressure-induced phase transitions and superconductivity in a black phosphorus single crystalPNAS January 15, 2019 116 (3) 1065; published ahead of print January 7, 2019. https://doi.org/10.1073/pnas.1821331116
- You have accessCorrection for Paluck et al., Changing climates of conflict: A social network experiment in 56 schoolsPNAS January 15, 2019 116 (3) 1066; published ahead of print January 7, 2019. https://doi.org/10.1073/pnas.1821346116
- You have accessCorrection for Terui et al., Metapopulation stability in branching river networksPNAS January 15, 2019 116 (3) 1067-1068; published ahead of print January 7, 2019. https://doi.org/10.1073/pnas.1821107116
- You have accessCorrection for Zella et al., Mycoplasma promotes malignant transformation in vivo, and its DnaK, a bacterial chaperon protein, has broad oncogenic propertiesPNAS January 15, 2019 116 (3) 1069; published ahead of print January 7, 2019. https://doi.org/10.1073/pnas.1821037116
Commentaries