Table of Contents

Biological Sciences

• Agricultural Sciences

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    Reviving rare chicken breeds using genetically engineered sterility in surrogate host birds

    Mark E. Woodcock, Almas A. Gheyas, Andrew S. Mason, Sunil Nandi, Lorna Taylor, Adrian Sherman, Jacqueline Smith, Dave W. Burt, Rachel Hawken, and Michael J. McGrew

    PNAS October 15, 2019 116 (42) 20930-20937; first published October 1, 2019. https://doi.org/10.1073/pnas.1906316116
  • Open Access

    Xanthomonas translucens commandeers the host rate-limiting step in ABA biosynthesis for disease susceptibility

    Zhao Peng, Ying Hu, Junli Zhang, Jose C. Huguet-Tapia, Anna K. Block, Sunghun Park, Suraj Sapkota, Zhaohui Liu, Sanzhen Liu, and Frank F. White

    PNAS October 15, 2019 116 (42) 20938-20946; first published October 1, 2019. https://doi.org/10.1073/pnas.1911660116

• Applied Biological Sciences

  • Open Access

    Engineering the stereoisomeric structure of seed oil to mimic human milk fat

    Harrie van Erp, Fiona M. Bryant, Jose Martin-Moreno, Louise V. Michaelson, Govindprasad Bhutada, and Peter J. Eastmond

    PNAS October 15, 2019 116 (42) 20947-20952; first published September 30, 2019. https://doi.org/10.1073/pnas.1907915116
  • Open Access

    A large-scale study reveals 24-h operational rhythms in hospital treatment

    Marc D. Ruben, Lauren J. Francey, Yuping Guo, Gang Wu, Edward B. Cooper, Amy S. Shah, John B. Hogenesch, and David F. Smith

    PNAS October 15, 2019 116 (42) 20953-20958; first published October 1, 2019. https://doi.org/10.1073/pnas.1909557116
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    Francisella novicida Cas9 interrogates genomic DNA with very high specificity and can be used for mammalian genome editing

    Sundaram Acharya, Arpit Mishra, Deepanjan Paul, Asgar Hussain Ansari, Mohd. Azhar, Manoj Kumar, Riya Rauthan, Namrata Sharma, Meghali Aich, Dipanjali Sinha, Saumya Sharma, Shivani Jain, Arjun Ray, Suman Jain, Sivaprakash Ramalingam, Souvik Maiti, and Debojyoti Chakraborty

    PNAS October 15, 2019 116 (42) 20959-20968; first published September 30, 2019. https://doi.org/10.1073/pnas.1818461116

• Biochemistry

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    Rationally engineered Staphylococcus aureus Cas9 nucleases with high genome-wide specificity

    Yuanyan Tan, Athena H. Y. Chu, Siyu Bao, Duc Anh Hoang, Firaol Tamiru Kebede, Wenjun Xiong, Mingfang Ji, Jiahai Shi, and Zongli Zheng

    PNAS October 15, 2019 116 (42) 20969-20976; first published September 30, 2019. https://doi.org/10.1073/pnas.1906843116
  • Open Access

    Rotational symmetry of the structured Chip/LDB-SSDP core module of the Wnt enhanceosome

    Miha Renko, Marc Fiedler, Trevor J. Rutherford, Jonas V. Schaefer, Andreas Plückthun, and Mariann Bienz

    PNAS October 15, 2019 116 (42) 20977-20983; first published September 30, 2019. https://doi.org/10.1073/pnas.1912705116
  • Open Access

    Structural basis of light-induced redox regulation in the Calvin–Benson cycle in cyanobacteria

    Ciaran R. McFarlane, Nita R. Shah, Burak V. Kabasakal, Blanca Echeverria, Charles A. R. Cotton, Doryen Bubeck, and James W. Murray

    PNAS October 15, 2019 116 (42) 20984-20990; first published September 30, 2019. https://doi.org/10.1073/pnas.1906722116
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    A CTG repeat-selective chemical screen identifies microtubule inhibitors as selective modulators of toxic CUG RNA levels

    Kaalak Reddy, Jana R. Jenquin, Ona L. McConnell, John D. Cleary, Jared I. Richardson, Belinda S. Pinto, Maja C. Haerle, Elizabeth Delgado, Lori Planco, Masayuki Nakamori, Eric T. Wang, and J. Andrew Berglund

    PNAS October 15, 2019 116 (42) 20991-21000; first published September 30, 2019. https://doi.org/10.1073/pnas.1901893116
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    Mapping low-affinity/high-specificity peptide–protein interactions using ligand-footprinting mass spectrometry

    Benjamin W. Parker, Edward J. Goncz, David T. Krist, Alexander V. Statsyuk, Alexey I. Nesvizhskii, and Eric L. Weiss

    PNAS October 15, 2019 116 (42) 21001-21011; first published October 2, 2019. https://doi.org/10.1073/pnas.1819533116
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    Overcoming insecticide resistance through computational inhibitor design

    Galen J. Correy, Daniel Zaidman, Alon Harmelin, Silvia Carvalho, Peter D. Mabbitt, Viviane Calaora, Peter J. James, Andrew C. Kotze, Colin J. Jackson, and Nir London

    PNAS October 15, 2019 116 (42) 21012-21021; first published October 1, 2019. https://doi.org/10.1073/pnas.1909130116

• Biophysics and Computational Biology

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    Theory and simulations for RNA folding in mixtures of monovalent and divalent cations

    Hung T. Nguyen, Naoto Hori, and D. Thirumalai

    PNAS October 15, 2019 116 (42) 21022-21030; first published September 30, 2019. https://doi.org/10.1073/pnas.1911632116
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    How internal cavities destabilize a protein

    Mengjun Xue, Takuro Wakamoto, Camilla Kejlberg, Yuichi Yoshimura, Tania Aaquist Nielsen, Michael Wulff Risør, Kristian Wejse Sanggaard, Ryo Kitahara, and Frans A. A. Mulder

    PNAS October 15, 2019 116 (42) 21031-21036; first published September 30, 2019. https://doi.org/10.1073/pnas.1911181116
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    Capsid expansion of bacteriophage T5 revealed by high resolution cryoelectron microscopy

    Alexis Huet, Robert L. Duda, Pascale Boulanger, and James F. Conway

    PNAS October 15, 2019 116 (42) 21037-21046; first published October 2, 2019. https://doi.org/10.1073/pnas.1909645116

• Developmental Biology

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    Paternal knockout of Slc38a4/SNAT4 causes placental hypoplasia associated with intrauterine growth restriction in mice

    Shogo Matoba, Shoko Nakamuta, Kento Miura, Michiko Hirose, Hirosuke Shiura, Takashi Kohda, Nobuaki Nakamuta, and Atsuo Ogura

    PNAS October 15, 2019 116 (42) 21047-21053; first published September 30, 2019. https://doi.org/10.1073/pnas.1907884116
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    β-Catenin is required for radial cell patterning and identity in the developing mouse cochlea

    Lina Jansson, Michael Ebeid, Jessica W. Shen, Tara E. Mokhtari, Lee A. Quiruz, David M. Ornitz, Sung-Ho Huh, and Alan G. Cheng

    PNAS October 15, 2019 116 (42) 21054-21060; first published September 30, 2019. https://doi.org/10.1073/pnas.1910223116

• Ecology

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    The conflict between adaptation and dispersal for maintaining biodiversity in changing environments

    Patrick L. Thompson and Emanuel A. Fronhofer

    PNAS October 15, 2019 116 (42) 21061-21067; first published September 30, 2019. https://doi.org/10.1073/pnas.1911796116

• Evolution

  • Open Access

    On the feasibility of saltational evolution

    Mikhail I. Katsnelson, Yuri I. Wolf, and Eugene V. Koonin

    PNAS October 15, 2019 116 (42) 21068-21075; first published September 30, 2019. https://doi.org/10.1073/pnas.1909031116
  • Open Access

    Multiple modes of convergent adaptation in the spread of glyphosate-resistant Amaranthus tuberculatus

    Julia M. Kreiner, Darci Ann Giacomini, Felix Bemm, Bridgit Waithaka, Julian Regalado, Christa Lanz, Julia Hildebrandt, Peter H. Sikkema, Patrick J. Tranel, Detlef Weigel, John R. Stinchcombe, and Stephen I. Wright

    PNAS October 15, 2019 116 (42) 21076-21084; first published September 30, 2019. https://doi.org/10.1073/pnas.1900870116
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    Empirical measures of mutational effects define neutral models of regulatory evolution in Saccharomyces cerevisiae

    Andrea Hodgins-Davis, Fabien Duveau, Elizabeth A. Walker, and Patricia J. Wittkopp

    PNAS October 15, 2019 116 (42) 21085-21093; first published September 30, 2019. https://doi.org/10.1073/pnas.1902823116
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    A functional enrichment test for molecular convergent evolution finds a clear protein-coding signal in echolocating bats and whales

    Amir Marcovitz, Yatish Turakhia, Heidi I. Chen, Michael Gloudemans, Benjamin A. Braun, Haoqing Wang, and Gill Bejerano

    PNAS October 15, 2019 116 (42) 21094-21103; first published September 30, 2019. https://doi.org/10.1073/pnas.1818532116
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    Allele-specific nonstationarity in evolution of influenza A virus surface proteins

    Anfisa V. Popova, Ksenia R. Safina, Vasily V. Ptushenko, Anastasia V. Stolyarova, Alexander V. Favorov, Alexey D. Neverov, and Georgii A. Bazykin

    PNAS October 15, 2019 116 (42) 21104-21112; first published October 2, 2019. https://doi.org/10.1073/pnas.1904246116

• Immunology and Inflammation

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    Cowpox virus encodes a protein that binds B7.1 and B7.2 and subverts T cell costimulation

    Xiaoli Wang, Sytse J. Piersma, Jabari I. Elliott, John M. Errico, Maria D. Gainey, Liping Yang, Christopher A. Nelson, Wayne M. Yokoyama, and Daved H. Fremont

    PNAS October 15, 2019 116 (42) 21113-21119; first published October 1, 2019. https://doi.org/10.1073/pnas.1909414116
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    IL-2 receptors preassemble and signal in the ER/Golgi causing resistance to antiproliferative anti–IL-2Rα therapies

    Julianna Volkó, Ádám Kenesei, Meili Zhang, Péter Várnai, Gábor Mocsár, Michael N. Petrus, Károly Jambrovics, Zoltán Balajthy, Gabriele Müller, Andrea Bodnár, Katalin Tóth, Thomas A. Waldmann, and György Vámosi

    PNAS October 15, 2019 116 (42) 21120-21130; first published September 30, 2019. https://doi.org/10.1073/pnas.1901382116
  • Open Access

    Extrapituitary prolactin promotes generation of Eomes-positive helper T cells mediating neuroinflammation

    Chenyang Zhang, Ben J. E. Raveney, Hirohiko Hohjoh, Chiharu Tomi, Shinji Oki, and Takashi Yamamura

    PNAS October 15, 2019 116 (42) 21131-21139; first published September 30, 2019. https://doi.org/10.1073/pnas.1906438116
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    RORα is crucial for attenuated inflammatory response to maintain intestinal homeostasis

    Se Kyu Oh, Dongha Kim, Kyeongkyu Kim, Kyungjin Boo, Young Suk Yu, Ik Soo Kim, Yoon Jeon, Sun-Kyoung Im, Su-Hyung Lee, Ji Min Lee, Younhee Ko, Ho Lee, Daechan Park, Sungsoon Fang, and Sung Hee Baek

    PNAS October 15, 2019 116 (42) 21140-21149; first published September 30, 2019. https://doi.org/10.1073/pnas.1907595116

• Medical Sciences

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    Lipid nanoparticle-targeted mRNA therapy as a treatment for the inherited metabolic liver disorder arginase deficiency

    • From the Cover

    Brian Truong, Gabriella Allegri, Xiao-Bo Liu, Kristine E. Burke, Xuling Zhu, Stephen D. Cederbaum, Johannes Häberle, Paolo G. V. Martini, and Gerald S. Lipshutz

    PNAS October 15, 2019 116 (42) 21150-21159; first published September 9, 2019. https://doi.org/10.1073/pnas.1906182116

    See companion article:

    • Messenger RNA therapy as an option for treating metabolic disorders

      - Sep 19, 2019

• Microbiology

  • Open Access

    Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell

    Mattie C. Pawlowic, Mastanbabu Somepalli, Adam Sateriale, Gillian T. Herbert, Alexis R. Gibson, Gregory D. Cuny, Lizbeth Hedstrom, and Boris Striepen

    PNAS October 15, 2019 116 (42) 21160-21165; first published September 30, 2019. https://doi.org/10.1073/pnas.1908239116
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    The cbb₃-type cytochrome oxidase assembly factor CcoG is a widely distributed cupric reductase

    Dorian Marckmann, Petru-Iulian Trasnea, Johannes Schimpf, Christine Winterstein, Andreea Andrei, Stefan Schmollinger, Crysten E. Blaby-Haas, Thorsten Friedrich, Fevzi Daldal, and Hans-Georg Koch

    PNAS October 15, 2019 116 (42) 21166-21175; first published September 30, 2019. https://doi.org/10.1073/pnas.1913803116

• Neuroscience

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    Photopotentiation of the GABA_A receptor with caged diazepam

    Lorenzo Sansalone, Joshua Bratsch-Prince, Sicheng Tang, Burjor Captain, David D. Mott, and Françisco M. Raymo

    PNAS October 15, 2019 116 (42) 21176-21184; first published October 1, 2019. https://doi.org/10.1073/pnas.1902383116
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    Laminar specific fMRI reveals directed interactions in distributed networks during language processing

    Daniel Sharoh, Tim van Mourik, Lauren J. Bains, Katrien Segaert, Kirsten Weber, Peter Hagoort, and David G. Norris

    PNAS October 15, 2019 116 (42) 21185-21190; first published September 30, 2019. https://doi.org/10.1073/pnas.1907858116
  • Open Access

    Genetic dissection of active forgetting in labile and consolidated memories in Drosophila

    • From the Cover

    Yang Gao, Yichun Shuai, Xuchen Zhang, Yuwei Peng, Lianzhang Wang, Jing He, Yi Zhong, and Qian Li

    PNAS October 15, 2019 116 (42) 21191-21197; first published September 5, 2019. https://doi.org/10.1073/pnas.1903763116

    See companion article:

    • Forgetting memories through distinct actin remodeling mechanisms

      - Sep 17, 2019
  • Open Access

    Amyloid-beta impairs TOM1-mediated IL-1R1 signaling

    Alessandra Cadete Martini, Angela Gomez-Arboledas, Stefania Forner, Carlos J. Rodriguez-Ortiz, Amanda McQuade, Emma Danhash, Jimmy Phan, Dominic Javonillo, Jordan-Vu Ha, Melanie Tram, Laura Trujillo-Estrada, Celia da Cunha, Rahasson R. Ager, Jose C. Davila, Masashi Kitazawa, Mathew Blurton-Jones, Antonia Gutierrez, David Baglietto-Vargas, Rodrigo Medeiros, and Frank M. LaFerla

    PNAS October 15, 2019 116 (42) 21198-21206; first published September 30, 2019. https://doi.org/10.1073/pnas.1914088116

    See companion article:

    • Reply to Peng and Zhao: Loss of endocytic protein TOM1 in Alzheimer’s disease

      - Feb 11, 2020
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    N-terminal alternative splicing of GluN1 regulates the maturation of excitatory synapses and seizure susceptibility

    Hong Liu, Hao Wang, Matthew Peterson, Wen Zhang, Guoqiang Hou, and Zhong-wei Zhang

    PNAS October 15, 2019 116 (42) 21207-21212; first published September 30, 2019. https://doi.org/10.1073/pnas.1905721116
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    Gray Matter Age Prediction as a Biomarker for Risk of Dementia

    Johnny Wang, Maria J. Knol, Aleksei Tiulpin, Florian Dubost, Marleen de Bruijne, Meike W. Vernooij, Hieab H. H. Adams, M. Arfan Ikram, Wiro J. Niessen, and Gennady V. Roshchupkin

    PNAS October 15, 2019 116 (42) 21213-21218; first published October 1, 2019. https://doi.org/10.1073/pnas.1902376116
  • Open Access

    Gradients of structure–function tethering across neocortex

    Bertha Vázquez-Rodríguez, Laura E. Suárez, Ross D. Markello, Golia Shafiei, Casey Paquola, Patric Hagmann, Martijn P. van den Heuvel, Boris C. Bernhardt, R. Nathan Spreng, and Bratislav Misic

    PNAS October 15, 2019 116 (42) 21219-21227; first published September 30, 2019. https://doi.org/10.1073/pnas.1903403116
  • Open Access

    Muscle acetylcholine receptor conversion into chloride conductance at positive potentials by a single mutation

    Hakan Cetin, Max Epstein, Wei W. Liu, Susan Maxwell, Pedro M. Rodriguez Cruz, Judith Cossins, Angela Vincent, Richard Webster, Philip C. Biggin, and David Beeson

    PNAS October 15, 2019 116 (42) 21228-21235; first published September 30, 2019. https://doi.org/10.1073/pnas.1908284116

• Pharmacology

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    KCNQ5 activation is a unifying molecular mechanism shared by genetically and culturally diverse botanical hypotensive folk medicines

    Rían W. Manville, Jennifer van der Horst, Kaitlyn E. Redford, Benjamin B. Katz, Thomas A. Jepps, and Geoffrey W. Abbott

    PNAS October 15, 2019 116 (42) 21236-21245; first published September 30, 2019. https://doi.org/10.1073/pnas.1907511116

• Plant Biology

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    Structure of a C₂S₂M₂N₂-type PSII–LHCII supercomplex from the green alga Chlamydomonas reinhardtii

    Liangliang Shen, Zihui Huang, Shenghai Chang, Wenda Wang, Jingfen Wang, Tingyun Kuang, Guangye Han, Jian-Ren Shen, and Xing Zhang

    PNAS October 15, 2019 116 (42) 21246-21255; first published September 30, 2019. https://doi.org/10.1073/pnas.1912462116
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    Mining for protein S-sulfenylation in Arabidopsis uncovers redox-sensitive sites

    Jingjing Huang, Patrick Willems, Bo Wei, Caiping Tian, Renan B. Ferreira, Nandita Bodra, Santiago Agustín Martínez Gache, Khadija Wahni, Keke Liu, Didier Vertommen, Kris Gevaert, Kate S. Carroll, Marc Van Montagu, Jing Yang, Frank Van Breusegem, and Joris Messens

    PNAS October 15, 2019 116 (42) 21256-21261; first published October 2, 2019. https://doi.org/10.1073/pnas.1906768116
  • Open Access

    GWAS with principal component analysis identifies a gene comprehensively controlling rice architecture

    Kenji Yano, Yoichi Morinaka, Fanmiao Wang, Peng Huang, Sayaka Takehara, Takaaki Hirai, Aya Ito, Eriko Koketsu, Mayuko Kawamura, Kunihiko Kotake, Shinya Yoshida, Masaki Endo, Gen Tamiya, Hidemi Kitano, Miyako Ueguchi-Tanaka, Ko Hirano, and Makoto Matsuoka

    PNAS October 15, 2019 116 (42) 21262-21267; first published September 30, 2019. https://doi.org/10.1073/pnas.1904964116
  • Open Access

    Light-inducible expression of translation factor EF-Tu during acclimation to strong light enhances the repair of photosystem II

    Haruhiko Jimbo, Taichi Izuhara, Yukako Hihara, Toru Hisabori, and Yoshitaka Nishiyama

    PNAS October 15, 2019 116 (42) 21268-21273; first published September 30, 2019. https://doi.org/10.1073/pnas.1909520116
  • Open Access

    Salicylic acid-mediated plasmodesmal closure via Remorin-dependent lipid organization

    Dingquan Huang, Yanbiao Sun, Zhiming Ma, Meiyu Ke, Yong Cui, Zichen Chen, Chaofan Chen, Changyang Ji, Tuan Minh Tran, Liang Yang, Sin Man Lam, Yanhong Han, Guanghou Shui, Zhuang Wei, Shutang Tan, Kan Liao, Jiří Friml, Yansong Miao, Liwen Jiang, and Xu Chen

    PNAS October 15, 2019 116 (42) 21274-21284; first published October 1, 2019. https://doi.org/10.1073/pnas.1911892116
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    Noncanonical auxin signaling regulates cell division pattern during lateral root development

    Rongfeng Huang, Rui Zheng, Jun He, Zimin Zhou, Jiacheng Wang, Yan Xiong, and Tongda Xu

    PNAS October 15, 2019 116 (42) 21285-21290; first published September 30, 2019. https://doi.org/10.1073/pnas.1910916116
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    Interaction between VPS35 and RABG3f is necessary as a checkpoint to control fusion of late compartments with the vacuole

    Cecilia Rodriguez-Furlan, David Domozych, Weixing Qian, Per-Anders Enquist, Xiaohui Li, Chunhua Zhang, Rolf Schenk, Holly Saulsbery Winbigler, William Jackson, Natasha V. Raikhel, and Glenn R. Hicks

    PNAS October 15, 2019 116 (42) 21291-21301; first published September 30, 2019. https://doi.org/10.1073/pnas.1905321116

• Population Biology

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    Contemporary evolution of maize landraces and their wild relatives influenced by gene flow with modern maize varieties

    Idalia C. Rojas-Barrera, Ana Wegier, José de Jesús Sánchez González, Gregory L. Owens, Loren H. Rieseberg, and Daniel Piñero

    PNAS October 15, 2019 116 (42) 21302-21311; first published September 30, 2019. https://doi.org/10.1073/pnas.1817664116

• Psychological and Cognitive Sciences

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    Distinct representations of spatial and categorical relationships across human scene-selective cortex

    Andrew S. Persichetti and Daniel D. Dilks

    PNAS October 15, 2019 116 (42) 21312-21317; first published September 30, 2019. https://doi.org/10.1073/pnas.1903057116
  • Open Access

    Neural dynamics of semantic composition

    Bingjiang Lyu, Hun S. Choi, William D. Marslen-Wilson, Alex Clarke, Billi Randall, and Lorraine K. Tyler

    PNAS October 15, 2019 116 (42) 21318-21327; first published September 30, 2019. https://doi.org/10.1073/pnas.1903402116