Battery-free, lightweight, injectable microsystem for in vivo wireless pharmacology and optogenetics

Yi Zhang; Daniel C. Castro; Yuan Han; Yixin Wu; Hexia Guo; Zhengyan Weng; Yeguang Xue; Jokubas Ausra; Xueju Wang; Rui Li; Guangfu Wu; Abraham Vázquez-Guardado; Yiwen Xie; Zhaoqian Xie; Diana Ostojich; Dongsheng Peng; Rujie Sun; Binbin Wang; Yongjoon Yu; John P. Leshock; Subing Qu; Chun-Ju Su; Wen Shen; Tao Hang; Anthony Banks; Yonggang Huang; Jelena Radulovic; Philipp Gutruf; Michael R. Bruchas; John A. Rogers

doi:10.1073/pnas.1909850116

New Research In

Physical Sciences

Featured Portals

Physics
Chemistry
Sustainability Science

Articles by Topic

Applied Mathematics
Applied Physical Sciences
Astronomy
Computer Sciences
Earth, Atmospheric, and Planetary Sciences
Engineering
Environmental Sciences
Mathematics
Statistics

Social Sciences

Featured Portals

Anthropology
Sustainability Science

Articles by Topic

Economic Sciences
Environmental Sciences
Political Sciences
Psychological and Cognitive Sciences
Social Sciences

Biological Sciences

Featured Portals

Sustainability Science

Articles by Topic

Agricultural Sciences
Anthropology
Applied Biological Sciences
Biochemistry
Biophysics and Computational Biology
Cell Biology
Developmental Biology
Ecology
Environmental Sciences
Evolution
Genetics
Immunology and Inflammation
Medical Sciences
Microbiology
Neuroscience
Pharmacology
Physiology
Plant Biology
Population Biology
Psychological and Cognitive Sciences
Sustainability Science
Systems Biology

Research Article

Battery-free, lightweight, injectable microsystem for in vivo wireless pharmacology and optogenetics

Yi Zhang, Daniel C. Castro, Yuan Han, Yixin Wu, Hexia Guo, Zhengyan Weng, View ORCID ProfileYeguang Xue, Jokubas Ausra, Xueju Wang, Rui Li, Guangfu Wu, Abraham Vázquez-Guardado, Yiwen Xie, Zhaoqian Xie, Diana Ostojich, Dongsheng Peng, Rujie Sun, Binbin Wang, Yongjoon Yu, John P. Leshock, Subing Qu, Chun-Ju Su, Wen Shen, Tao Hang, Anthony Banks, Yonggang Huang, Jelena Radulovic, Philipp Gutruf, Michael R. Bruchas, and John A. Rogers

PNAS October 22, 2019 116 (43) 21427-21437; first published October 10, 2019 https://doi.org/10.1073/pnas.1909850116

Yi Zhang

aDepartment of Biomedical, Biological, and Chemical Engineering, University of Missouri, Columbia, MO 65211;bDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL 60208;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Daniel C. Castro

cDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98195;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Yuan Han

dDepartment of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL 60611;eDepartment of Anesthesiology, Eye & ENT Hospital, Fudan University, 200031 Shanghai, China;fJiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, 221004 Xuzhou, China;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Yixin Wu

bDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL 60208;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Hexia Guo

bDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL 60208;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Zhengyan Weng

aDepartment of Biomedical, Biological, and Chemical Engineering, University of Missouri, Columbia, MO 65211;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Yeguang Xue

bDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL 60208;gDepartment of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208;hDepartment of Mechanical Engineering, Northwestern University, Evanston, IL 60208;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Yeguang Xue

Jokubas Ausra

iBiomedical Engineering, College of Engineering, The University of Arizona, Tucson, AZ 85721;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Xueju Wang

jDepartment of Mechanical and Aerospace Engineering, University of Missouri, Columbia, MO 65211;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Rui Li

kState Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, 116024 Dalian, China;lInternational Research Center for Computational Mechanics, Dalian University of Technology, 116024 Dalian, China;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Guangfu Wu

aDepartment of Biomedical, Biological, and Chemical Engineering, University of Missouri, Columbia, MO 65211;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Abraham Vázquez-Guardado

mCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Yiwen Xie

bDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL 60208;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Zhaoqian Xie

gDepartment of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208;hDepartment of Mechanical Engineering, Northwestern University, Evanston, IL 60208;kState Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, 116024 Dalian, China;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Diana Ostojich

bDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL 60208;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Dongsheng Peng

nCollege of Optoelectronic Engineering, Shenzhen University, 518060 Shenzhen, China;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Rujie Sun

oBristol Composites Institute, University of Bristol, BS8 1TR Bristol, United Kingdom;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Binbin Wang

pDepartment of Civil and Environmental Engineering, University of Missouri, Columbia, MO 65211;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Yongjoon Yu

qNeuroLux, Inc., Evanston, IL 60201;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

John P. Leshock

bDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL 60208;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Subing Qu

rDepartment of Materials Science and Engineering, Materials Research Laboratory, University of Illinois at Urbana–Champaign, Urbana, IL 61801;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Chun-Ju Su

bDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL 60208;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Wen Shen

sDepartment of Mechanical and Aerospace Engineering, University of Texas at Arlington, Arlington, TX 76019;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Tao Hang

tSchool of Materials Science and Engineering, Shanghai Jiao Tong University, 200240 Shanghai, China;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Anthony Banks

bDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL 60208;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Yonggang Huang

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jelena Radulovic

dDepartment of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL 60611;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Philipp Gutruf

iBiomedical Engineering, College of Engineering, The University of Arizona, Tucson, AZ 85721;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: pgutruf@email.arizona.edu mbruchas@uw.edu jrogers@northwestern.edu

Michael R. Bruchas

cDepartment of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98195;uCenter for Neurobiology of Addiction, Pain, and Emotion, University of Washington, Seattle, WA 98195;vDepartment of Pharmacology, University of Washington, Seattle, WA 98195;

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: pgutruf@email.arizona.edu mbruchas@uw.edu jrogers@northwestern.edu

John A. Rogers

bDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL 60208;mCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208;wSimpson Querrey Institute, Northwestern University, Chicago, IL 60611;xDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208;yDepartment of Chemistry, Northwestern University, Evanston, IL 60208;zDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
For correspondence: pgutruf@email.arizona.edu mbruchas@uw.edu jrogers@northwestern.edu

Edited by Marcus E. Raichle, Washington University in St. Louis, St. Louis, MO, and approved September 10, 2019 (received for review June 8, 2019)

Article
Figures & SI
Info & Metrics
PDF

Log in using your username and password

Username *

Password *

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.

Subscribers, for more details, please visit our Subscriptions FAQ.

Please click here to log into the PNAS submission website.

Data supplements

Supporting Information

Download Appendix (PDF)
Download Movie_S01 (MP4) - Mice implanted with the device show normal behaviors. Two mice implanted with the device show normal locomotor (e.g., rearing, walking, exploring) and social (e.g., sniffing, climbing) behaviors.

Article Alerts

User Name *

Password *

Email Article

Thank you for your interest in spreading the word on PNAS.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following Battery-free, lightweight, injectable microsystem for in vivo wireless pharmacology and optogenetics

Message Subject (Your Name) has sent you a message from PNAS

Message Body (Your Name) thought you would like to see the PNAS web site.

Your Personal Message

Citation Tools

Battery-free, lightweight, injectable microsystem for in vivo wireless pharmacology and optogenetics

Yi Zhang, Daniel C. Castro, Yuan Han, Yixin Wu, Hexia Guo, Zhengyan Weng, Yeguang Xue, Jokubas Ausra, Xueju Wang, Rui Li, Guangfu Wu, Abraham Vázquez-Guardado, Yiwen Xie, Zhaoqian Xie, Diana Ostojich, Dongsheng Peng, Rujie Sun, Binbin Wang, Yongjoon Yu, John P. Leshock, Subing Qu, Chun-Ju Su, Wen Shen, Tao Hang, Anthony Banks, Yonggang Huang, Jelena Radulovic, Philipp Gutruf, Michael R. Bruchas, John A. Rogers

Proceedings of the National Academy of Sciences Oct 2019, 116 (43) 21427-21437; DOI: 10.1073/pnas.1909850116