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Research Article

IL-10–producing B cells are enriched in murine pericardial adipose tissues and ameliorate the outcome of acute myocardial infarction

View ORCID ProfileLan Wu, Rajeev Dalal, Connie D. Cao, J. Luke Postoak, Guan Yang, Qinkun Zhang, Zhizhang Wang, Hind Lal, and Luc Van Kaer
PNAS October 22, 2019 116 (43) 21673-21684; first published October 7, 2019 https://doi.org/10.1073/pnas.1911464116
Lan Wu
aDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232;
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  • ORCID record for Lan Wu
  • For correspondence: lan.wu.1@vumc.org luc.van.kaer@vumc.org
Rajeev Dalal
aDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232;
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Connie D. Cao
aDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232;
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J. Luke Postoak
aDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232;
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Guan Yang
aDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232;
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Qinkun Zhang
bDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232;
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Zhizhang Wang
cVanderbilt–NIH Mouse Metabolic Phenotyping Center, Vanderbilt University Medical Center, Nashville, TN 37232
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Hind Lal
bDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232;
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Luc Van Kaer
aDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232;
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  • For correspondence: lan.wu.1@vumc.org luc.van.kaer@vumc.org
  1. Edited by Ajay Chawla, University of California, San Francisco, CA, and accepted by Editorial Board Member Philippa Marrack September 13, 2019 (received for review July 9, 2019)

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Article Information

vol. 116 no. 43 21673-21684
DOI: 
https://doi.org/10.1073/pnas.1911464116
PubMed: 
31591231

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue October 22, 2019.
  • Published first October 7, 2019.

Copyright & Usage: 
© 2019 Published under the PNAS license.

Author Information

  1. Lan Wua,1,
  2. Rajeev Dalala,
  3. Connie D. Caoa,
  4. J. Luke Postoaka,
  5. Guan Yanga,
  6. Qinkun Zhangb,
  7. Zhizhang Wangc,
  8. Hind Lalb, and
  9. Luc Van Kaera,1
  1. aDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232;
  2. bDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232;
  3. cVanderbilt–NIH Mouse Metabolic Phenotyping Center, Vanderbilt University Medical Center, Nashville, TN 37232
  1. Edited by Ajay Chawla, University of California, San Francisco, CA, and accepted by Editorial Board Member Philippa Marrack September 13, 2019 (received for review July 9, 2019)

Footnotes

  • ↵1To whom correspondence may be addressed. Email: lan.wu.1{at}vumc.org or luc.van.kaer{at}vumc.org.
  • Author contributions: L.W. and L.V.K. designed research; L.W., R.D., C.D.C., J.L.P., G.Y., Q.Z., and Z.W. performed research; L.W. and H.L. analyzed data; and L.W. and L.V.K. wrote the paper.

  • The authors declare no competing interest.

  • This article is a PNAS Direct Submission. A.C. is a guest editor invited by the Editorial Board.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1911464116/-/DCSupplemental.

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Article usage: October 2019 to December 2019

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IL-10–producing B cells are enriched in murine pericardial adipose tissues and ameliorate the outcome of acute myocardial infarction
Lan Wu, Rajeev Dalal, Connie D. Cao, J. Luke Postoak, Guan Yang, Qinkun Zhang, Zhizhang Wang, Hind Lal, Luc Van Kaer
Proceedings of the National Academy of Sciences Oct 2019, 116 (43) 21673-21684; DOI: 10.1073/pnas.1911464116

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IL-10–producing B cells are enriched in murine pericardial adipose tissues and ameliorate the outcome of acute myocardial infarction
Lan Wu, Rajeev Dalal, Connie D. Cao, J. Luke Postoak, Guan Yang, Qinkun Zhang, Zhizhang Wang, Hind Lal, Luc Van Kaer
Proceedings of the National Academy of Sciences Oct 2019, 116 (43) 21673-21684; DOI: 10.1073/pnas.1911464116
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