Proceedings of the National Academy of Sciences: 116 (48)

New Research In

November 26, 2019; vol. 116 no. 48

This Week in PNAS

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In This Issue
PNAS November 26, 2019 116 (48) 23863-23865; https://doi.org/10.1073/iti4819116

News Feature

An in-depth look at trending science issues.

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News Feature: Gene therapy successes point to better therapies
Front Matter
Elie Dolgin

PNAS November 26, 2019 116 (48) 23866-23870; https://doi.org/10.1073/pnas.1918306116

Commentaries

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Understanding how people detect social class from speech requires taking a cultural psychological perspective
Nicole M. Stephens and Sarah S. M. Townsend

PNAS November 26, 2019 116 (48) 23871-23873; first published November 6, 2019. https://doi.org/10.1073/pnas.1916908116
See companion article:
Evidence for the reproduction of social class in brief speech
- Nov 12, 2019
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Playing the long game wins the cohesion–adhesion rivalry
Richard C. Remsing

PNAS November 26, 2019 116 (48) 23874-23876; first published October 28, 2019. https://doi.org/10.1073/pnas.1916911116
See companion article:
A unified description of hydrophilic and superhydrophobic surfaces in terms of the wetting and drying transitions of liquids
- Nov 26, 2019
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Stress during pregnancy: Fetal males pay the price
Margaret M. McCarthy

PNAS November 26, 2019 116 (48) 23877-23879; first published November 6, 2019. https://doi.org/10.1073/pnas.1916909116
See companion article:
Maternal prenatal stress phenotypes associate with fetal neurodevelopment and birth outcomes
- Nov 26, 2019
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The DAGs of war
David Fisman and Ashleigh Tuite

PNAS November 26, 2019 116 (48) 23880-23882; first published November 7, 2019. https://doi.org/10.1073/pnas.1916910116
See companion article:
The exacerbation of Ebola outbreaks by conflict in the Democratic Republic of the Congo
- Nov 26, 2019

Letters

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The minimum mean paradox: A mechanical explanation for apparent experiment aversion
Robert Mislavsky, Berkeley J. Dietvorst, and Uri Simonsohn

PNAS November 26, 2019 116 (48) 23883-23884; first published November 6, 2019. https://doi.org/10.1073/pnas.1912413116
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Reply to Mislavsky et al.: Sometimes people really are averse to experiments
Michelle N. Meyer, Patrick R. Heck, Geoffrey S. Holtzman, Stephen M. Anderson, William Cai, Duncan J. Watts, and Christopher F. Chabris

PNAS November 26, 2019 116 (48) 23885-23886; first published November 12, 2019. https://doi.org/10.1073/pnas.1914509116
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Objecting to experiments that compare two unobjectionable policies or treatments
- May 28, 2019
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Rainfall regulation of grazed grasslands
Maowei Liang and Elise S. Gornish

PNAS November 26, 2019 116 (48) 23887-23888; first published October 29, 2019. https://doi.org/10.1073/pnas.1915399116
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Reply to Liang and Gornish: Climate and livestock grazing jointly regulate grassland ecosystem multifunctionality
Ling Wang and Deli Wang

PNAS November 26, 2019 116 (48) 23889-23890; first published October 29, 2019. https://doi.org/10.1073/pnas.1916205116
See companion article:
Diversifying livestock promotes multidiversity and multifunctionality in managed grasslands
- Mar 26, 2019

Brief Report

Open Access
WEE1 kinase inhibitor AZD1775 induces CDK1 kinase-dependent origin firing in unperturbed G1- and S-phase cells
Tatiana N. Moiseeva, Chenao Qian, Norie Sugitani, Hatice U. Osmanbeyoglu, and Christopher J. Bakkenist

PNAS November 26, 2019 116 (48) 23891-23893; first published November 11, 2019. https://doi.org/10.1073/pnas.1915108116

Physical Sciences

Applied Mathematics
- Open Access
  On the energy efficiency of cell migration in diverse physical environments
  Yizeng Li, Lingxing Yao, Yoichiro Mori, and Sean X. Sun
  
  PNAS November 26, 2019 116 (48) 23894-23900; first published November 12, 2019. https://doi.org/10.1073/pnas.1907625116
Applied Physical Sciences
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  A unified description of hydrophilic and superhydrophobic surfaces in terms of the wetting and drying transitions of liquids
  From the Cover
  
  Robert Evans, Maria C. Stewart, and Nigel B. Wilding
  
  PNAS November 26, 2019 116 (48) 23901-23908; first published October 14, 2019. https://doi.org/10.1073/pnas.1913587116
  
  See companion article:
  Playing the long game wins the cohesion–adhesion rivalry
  - Nov 26, 2019
- Open Access
  Crack engineering for the construction of arbitrary hierarchical architectures
  Wanbo Li, Miao Yu, Jing Sun, Kentaro Mochizuki, Siyu Chen, Huanxi Zheng, Jiaqian Li, Shuhuai Yao, Hongkai Wu, Beng S. Ong, Satoshi Kawata, Zuankai Wang, and Kangning Ren
  
  PNAS November 26, 2019 116 (48) 23909-23914; first published November 7, 2019. https://doi.org/10.1073/pnas.1915332116
Chemistry
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  Highly active oxygen evolution integrated with efficient CO₂ to CO electroreduction
  Yongtao Meng, Xiao Zhang, Wei-Hsuan Hung, Junkai He, Yi-Sheng Tsai, Yun Kuang, Michael J. Kenney, Jing-Jong Shyue, Yijin Liu, Kevin H. Stone, Xueli Zheng, Steven L. Suib, Meng-Chang Lin, Yongye Liang, and Hongjie Dai
  
  PNAS November 26, 2019 116 (48) 23915-23922; first published November 13, 2019. https://doi.org/10.1073/pnas.1915319116
- Open Access
  Real-time probing of chirality during a chemical reaction
  Denitsa Baykusheva, Daniel Zindel, Vít Svoboda, Elias Bommeli, Manuel Ochsner, Andres Tehlar, and Hans Jakob Wörner
  
  PNAS November 26, 2019 116 (48) 23923-23929; first published November 13, 2019. https://doi.org/10.1073/pnas.1907189116
Computer Sciences
- Open Access
  Quantification of the resilience of primary care networks by stress testing the health care system
  Donald Ruggiero Lo Sardo, Stefan Thurner, Johannes Sorger, Georg Duftschmid, Gottfried Endel, and Peter Klimek
  
  PNAS November 26, 2019 116 (48) 23930-23935; first published November 11, 2019. https://doi.org/10.1073/pnas.1904826116
Earth, Atmospheric, and Planetary Sciences
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  Heightened levels and seasonal inversion of riverine suspended sediment in a tropical biodiversity hot spot due to artisanal gold mining
  Evan N. Dethier, Shannon L. Sartain, and David A. Lutz
  
  PNAS November 26, 2019 116 (48) 23936-23941; first published November 11, 2019. https://doi.org/10.1073/pnas.1907842116
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  Normalized US hurricane damage estimates using area of total destruction, 1900−2018
  Aslak Grinsted, Peter Ditlevsen, and Jens Hesselbjerg Christensen
  
  PNAS November 26, 2019 116 (48) 23942-23946; first published November 11, 2019. https://doi.org/10.1073/pnas.1912277116
- Open Access
  Unraveling driving forces explaining significant reduction in satellite-inferred Arctic surface albedo since the 1980s
  Rudong Zhang, Hailong Wang, Qiang Fu, Philip J. Rasch, and Xuanji Wang
  
  PNAS November 26, 2019 116 (48) 23947-23953; first published November 11, 2019. https://doi.org/10.1073/pnas.1915258116
Engineering
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  Solvent fluctuations in the solvation shell determine the activation barrier for crystal growth rates
  Anish V. Dighe and Meenesh R. Singh
  
  PNAS November 26, 2019 116 (48) 23954-23959; first published November 11, 2019. https://doi.org/10.1073/pnas.1910691116
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  Metamaterials with engineered failure load and stiffness
  Sai Sharan Injeti, Chiara Daraio, and Kaushik Bhattacharya
  
  PNAS November 26, 2019 116 (48) 23960-23965; first published November 11, 2019. https://doi.org/10.1073/pnas.1911535116
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  Shockley–Queisser triangle predicts the thermodynamic efficiency limits of arbitrarily complex multijunction bifacial solar cells
  Muhammad A. Alam and M. Ryyan Khan
  
  PNAS November 26, 2019 116 (48) 23966-23971; first published November 12, 2019. https://doi.org/10.1073/pnas.1910745116
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  Label-free visualization and characterization of extracellular vesicles in breast cancer
  From the Cover
  
  Sixian You, Ronit Barkalifa, Eric J. Chaney, Haohua Tu, Jaena Park, Janet Elise Sorrells, Yi Sun, Yuan-Zhi Liu, Lin Yang, Danny Z. Chen, Marina Marjanovic, Saurabh Sinha, and Stephen A. Boppart
  
  PNAS November 26, 2019 116 (48) 24012-24018; first published November 15, 2019. https://doi.org/10.1073/pnas.1909243116
Physics
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  Superlattice-induced ferroelectricity in charge-ordered La_1/3Sr_2/3FeO₃
  Se Young Park, Karin M. Rabe, and Jeffrey B. Neaton
  
  PNAS November 26, 2019 116 (48) 23972-23976; first published November 11, 2019. https://doi.org/10.1073/pnas.1906513116
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  How collective asperity detachments nucleate slip at frictional interfaces
  Tom W. J. de Geus, Marko Popović, Wencheng Ji, Alberto Rosso, and Matthieu Wyart
  
  PNAS November 26, 2019 116 (48) 23977-23983; first published November 7, 2019. https://doi.org/10.1073/pnas.1906551116

Biological Sciences

Anthropology
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  Association of EGLN1 gene with high aerobic capacity of Peruvian Quechua at high altitude
  Tom D. Brutsaert, Melisa Kiyamu, Gianpietro Elias Revollendo, Jenna L. Isherwood, Frank S. Lee, Maria Rivera-Ch, Fabiola Leon-Velarde, Sudipta Ghosh, and Abigail W. Bigham
  
  PNAS November 26, 2019 116 (48) 24006-24011; first published November 11, 2019. https://doi.org/10.1073/pnas.1906171116
Applied Biological Sciences
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  Label-free visualization and characterization of extracellular vesicles in breast cancer
  From the Cover
  
  Sixian You, Ronit Barkalifa, Eric J. Chaney, Haohua Tu, Jaena Park, Janet Elise Sorrells, Yi Sun, Yuan-Zhi Liu, Lin Yang, Danny Z. Chen, Marina Marjanovic, Saurabh Sinha, and Stephen A. Boppart
  
  PNAS November 26, 2019 116 (48) 24012-24018; first published November 15, 2019. https://doi.org/10.1073/pnas.1909243116
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  Fast fit-free analysis of fluorescence lifetime imaging via deep learning
  Jason T. Smith, Ruoyang Yao, Nattawut Sinsuebphon, Alena Rudkouskaya, Nathan Un, Joseph Mazurkiewicz, Margarida Barroso, Pingkun Yan, and Xavier Intes
  
  PNAS November 26, 2019 116 (48) 24019-24030; first published November 12, 2019. https://doi.org/10.1073/pnas.1912707116
Biochemistry
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  Roles of singleton tryptophan motifs in COPI coat stability and vesicle tethering
  Sophie M. Travis, Bashkim Kokona, Robert Fairman, and Frederick M. Hughson
  
  PNAS November 26, 2019 116 (48) 24031-24040; first published November 11, 2019. https://doi.org/10.1073/pnas.1909697116
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  Probing the rice Rubisco–Rubisco activase interaction via subunit heterooligomerization
  Devendra Shivhare, Jediael Ng, Yi-Chin Candace Tsai, and Oliver Mueller-Cajar
  
  PNAS November 26, 2019 116 (48) 24041-24048; first published November 11, 2019. https://doi.org/10.1073/pnas.1914245116
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  Steric complementarity directs sequence promiscuous leader binding in RiPP biosynthesis
  Jonathan R. Chekan, Chayanid Ongpipattanakul, and Satish K. Nair
  
  PNAS November 26, 2019 116 (48) 24049-24055; first published November 12, 2019. https://doi.org/10.1073/pnas.1908364116
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  Structural studies of the eIF4E–VPg complex reveal a direct competition for capped RNA: Implications for translation
  Luciana Coutinho de Oliveira, Laurent Volpon, Amanda K. Rahardjo, Michael J. Osborne, Biljana Culjkovic-Kraljacic, Christian Trahan, Marlene Oeffinger, Benjamin H. Kwok, and Katherine L. B. Borden
  
  PNAS November 26, 2019 116 (48) 24056-24065; first published November 11, 2019. https://doi.org/10.1073/pnas.1904752116
Biophysics and Computational Biology
- Open Access
  Intrinsic elasticity of nucleosomes is encoded by histone variants and calibrated by their binding partners
  Daniël P. Melters, Mary Pitman, Tatini Rakshit, Emilios K. Dimitriadis, Minh Bui, Garegin A. Papoian, and Yamini Dalal
  
  PNAS November 26, 2019 116 (48) 24066-24074; first published November 11, 2019. https://doi.org/10.1073/pnas.1911880116
- Open Access
  mRNA structure regulates protein expression through changes in functional half-life
  David M. Mauger, B. Joseph Cabral, Vladimir Presnyak, Stephen V. Su, David W. Reid, Brooke Goodman, Kristian Link, Nikhil Khatwani, John Reynders, Melissa J. Moore, and Iain J. McFadyen
  
  PNAS November 26, 2019 116 (48) 24075-24083; first published November 11, 2019. https://doi.org/10.1073/pnas.1908052116
Cell Biology
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  T6SS and ExoA of flesh-eating Aeromonas hydrophila in peritonitis and necrotizing fasciitis during mono- and polymicrobial infections
  Ana Fernández-Bravo, Paul B. Kilgore, Jourdan A. Andersson, Elizabeth Blears, Maria José Figueras, Nur A. Hasan, Rita R. Colwell, Jian Sha, and Ashok K. Chopra
  
  PNAS November 26, 2019 116 (48) 24084-24092; first published November 11, 2019. https://doi.org/10.1073/pnas.1914395116
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  RAMP3 determines rapid recycling of atypical chemokine receptor-3 for guided angiogenesis
  Duncan I. Mackie, Natalie R. Nielsen, Matthew Harris, Smriti Singh, Reema B. Davis, Danica Dy, Graham Ladds, and Kathleen M. Caron
  
  PNAS November 26, 2019 116 (48) 24093-24099; first published November 11, 2019. https://doi.org/10.1073/pnas.1905561116
- Open Access
  Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration
  Andrew P. Voigt, Kelly Mulfaul, Nathaniel K. Mullin, Miles J. Flamme-Wiese, Joseph C. Giacalone, Edwin M. Stone, Budd A. Tucker, Todd E. Scheetz, and Robert F. Mullins
  
  PNAS November 26, 2019 116 (48) 24100-24107; first published November 11, 2019. https://doi.org/10.1073/pnas.1914143116
- Open Access
  aPKCi triggers basal extrusion of luminal mammary epithelial cells by tuning contractility and vinculin localization at cell junctions
  Clémentine Villeneuve, Emilie Lagoutte, Ludmilla de Plater, Samuel Mathieu, Jean-Baptiste Manneville, Jean-Léon Maître, Philippe Chavrier, and Carine Rossé
  
  PNAS November 26, 2019 116 (48) 24108-24114; first published November 7, 2019. https://doi.org/10.1073/pnas.1906779116
Developmental Biology
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  Early sarcomere and metabolic defects in a zebrafish pitx2c cardiac arrhythmia model
  Michelle M. Collins, Gustav Ahlberg, Camilla Vestergaard Hansen, Stefan Guenther, Rubén Marín-Juez, Anna M. Sokol, Hadil El-Sammak, Janett Piesker, Ylva Hellsten, Morten S. Olesen, Didier Y. R. Stainier, and Pia R. Lundegaard
  
  PNAS November 26, 2019 116 (48) 24115-24121; first published November 8, 2019. https://doi.org/10.1073/pnas.1913905116
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  Neural progenitor cells mediated by H2A.Z.2 regulate microglial development via Cxcl14 in the embryonic brain
  Zhongqiu Li, Yanxin Li, and Jianwei Jiao
  
  PNAS November 26, 2019 116 (48) 24122-24132; first published November 11, 2019. https://doi.org/10.1073/pnas.1913978116
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  Hepatocyte nuclear factor-1β regulates Wnt signaling through genome-wide competition with β-catenin/lymphoid enhancer binding factor
  Siu Chiu Chan, Ying Zhang, Marco Pontoglio, and Peter Igarashi
  
  PNAS November 26, 2019 116 (48) 24133-24142; first published November 11, 2019. https://doi.org/10.1073/pnas.1909452116
Ecology
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  Heightened levels and seasonal inversion of riverine suspended sediment in a tropical biodiversity hot spot due to artisanal gold mining
  Evan N. Dethier, Shannon L. Sartain, and David A. Lutz
  
  PNAS November 26, 2019 116 (48) 23936-23941; first published November 11, 2019. https://doi.org/10.1073/pnas.1907842116
- Open Access
  Prey-size plastics are invading larval fish nurseries
  Jamison M. Gove, Jonathan L. Whitney, Margaret A. McManus, Joey Lecky, Felipe C. Carvalho, Jennifer M. Lynch, Jiwei Li, Philipp Neubauer, Katharine A. Smith, Jana E. Phipps, Donald R. Kobayashi, Karla B. Balagso, Emily A. Contreras, Mark E. Manuel, Mark A. Merrifield, Jeffrey J. Polovina, Gregory P. Asner, Jeffrey A. Maynard, and Gareth J. Williams
  
  PNAS November 26, 2019 116 (48) 24143-24149; first published November 11, 2019. https://doi.org/10.1073/pnas.1907496116
Evolution
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  Introgression drives repeated evolution of winter coat color polymorphism in hares
  Iwona Giska, Liliana Farelo, João Pimenta, Fernando A. Seixas, Mafalda S. Ferreira, João P. Marques, Inês Miranda, Jérôme Letty, Hannes Jenny, Klaus Hackländer, Eyðfinn Magnussen, and José Melo-Ferreira
  
  PNAS November 26, 2019 116 (48) 24150-24156; first published November 11, 2019. https://doi.org/10.1073/pnas.1910471116
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  Sexually antagonistic selection promotes genetic divergence between males and females in an ant
  Pierre-André Eyer, Alexander J. Blumenfeld, and Edward L. Vargo
  
  PNAS November 26, 2019 116 (48) 24157-24163; first published November 12, 2019. https://doi.org/10.1073/pnas.1906568116
- Open Access
  Hidden resources in the Escherichia coli genome restore PLP synthesis and robust growth after deletion of the essential gene pdxB
  Juhan Kim, Jake J. Flood, Michael R. Kristofich, Cyrus Gidfar, Andrew B. Morgenthaler, Tobias Fuhrer, Uwe Sauer, Daniel Snyder, Vaughn S. Cooper, Christopher C. Ebmeier, William M. Old, and Shelley D. Copley
  
  PNAS November 26, 2019 116 (48) 24164-24173; first published November 11, 2019. https://doi.org/10.1073/pnas.1915569116
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  Parallel evolution of ancient, pleiotropic enhancers underlies butterfly wing pattern mimicry
  James J. Lewis, Rachel C. Geltman, Patrick C. Pollak, Kathleen E. Rondem, Steven M. Van Belleghem, Melissa J. Hubisz, Paul R. Munn, Linlin Zhang, Caleb Benson, Anyi Mazo-Vargas, Charles G. Danko, Brian A. Counterman, Riccardo Papa, and Robert D. Reed
  
  PNAS November 26, 2019 116 (48) 24174-24183; first published November 11, 2019. https://doi.org/10.1073/pnas.1907068116
Genetics
- Open Access
  A set of microRNAs coordinately controls tumorigenesis, invasion, and metastasis
  Iacovos P. Michael, Sadegh Saghafinia, and Douglas Hanahan
  
  PNAS November 26, 2019 116 (48) 24184-24195; first published November 8, 2019. https://doi.org/10.1073/pnas.1913307116
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  Genomic sites hypersensitive to ultraviolet radiation
  Sanjay Premi, Lynn Han, Sameet Mehta, James Knight, Dejian Zhao, Meg A. Palmatier, Karl Kornacker, and Douglas E. Brash
  
  PNAS November 26, 2019 116 (48) 24196-24205; first published November 13, 2019. https://doi.org/10.1073/pnas.1907860116
- Open Access
  Definitive demonstration by synthesis of genome annotation completeness
  Paul R. Jaschke, Gabrielle A. Dotson, Kay S. Hung, Diane Liu, and Drew Endy
  
  PNAS November 26, 2019 116 (48) 24206-24213; first published November 12, 2019. https://doi.org/10.1073/pnas.1905990116
Immunology and Inflammation
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  CRIg plays an essential role in intravascular clearance of bloodborne parasites by interacting with complement
  Gongguan Liu, Yong Fu, Mohammed Yosri, Yanli Chen, Peng Sun, Jinjun Xu, Mingshun Zhang, Donglei Sun, Ashley B. Strickland, Zachary B. Mackey, and Meiqing Shi
  
  PNAS November 26, 2019 116 (48) 24214-24220; first published November 13, 2019. https://doi.org/10.1073/pnas.1913443116
- Open Access
  Neutrophils promote VLA-4–dependent B cell antigen presentation and accumulation within the meninges during neuroinflammation
  Chelsea R. Parker Harp, Angela S. Archambault, Matthew Cheung, Jesse W. Williams, Rafael S. Czepielewski, Patrick C. Duncker, Aaron J. Kilgore, Aidan T. Miller, Benjamin M. Segal, Alfred H. J. Kim, Gwendalyn J. Randolph, and Gregory F. Wu
  
  PNAS November 26, 2019 116 (48) 24221-24230; first published November 7, 2019. https://doi.org/10.1073/pnas.1909098116
- Open Access
  Trisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity
  Paula Araya, Katherine A. Waugh, Kelly D. Sullivan, Nicolás G. Núñez, Emiliano Roselli, Keith P. Smith, Ross E. Granrath, Angela L. Rachubinski, Belinda Enriquez Estrada, Eric T. Butcher, Ross Minter, Kathryn D. Tuttle, Tullia C. Bruno, Mariana Maccioni, and Joaquín M. Espinosa
  
  PNAS November 26, 2019 116 (48) 24231-24241; first published November 7, 2019. https://doi.org/10.1073/pnas.1908129116
- Open Access
  Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians
  Kosuke Hashimoto, Tsukasa Kouno, Tomokatsu Ikawa, Norihito Hayatsu, Yurina Miyajima, Haruka Yabukami, Tommy Terooatea, Takashi Sasaki, Takahiro Suzuki, Matthew Valentine, Giovanni Pascarella, Yasushi Okazaki, Harukazu Suzuki, Jay W. Shin, Aki Minoda, Ichiro Taniuchi, Hideyuki Okano, Yasumichi Arai, Nobuyoshi Hirose, and Piero Carninci
  
  PNAS November 26, 2019 116 (48) 24242-24251; first published November 12, 2019. https://doi.org/10.1073/pnas.1907883116
Medical Sciences
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  Dysregulation of different classes of tRNA fragments in chronic lymphocytic leukemia
  Dario Veneziano, Luisa Tomasello, Veronica Balatti, Alexey Palamarchuk, Laura Z. Rassenti, Thomas J. Kipps, Yuri Pekarsky, and Carlo M. Croce
  
  PNAS November 26, 2019 116 (48) 24252-24258; first published November 13, 2019. https://doi.org/10.1073/pnas.1913695116
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  Mutant p53 antagonizes p63/p73-mediated tumor suppression via Notch1
  Jin Zhang, Wenqiang Sun, Xiangmudong Kong, Yanhong Zhang, Hee Jung Yang, Cong Ren, Yuqian Jiang, Mingyi Chen, and Xinbin Chen
  
  PNAS November 26, 2019 116 (48) 24259-24267; first published November 11, 2019. https://doi.org/10.1073/pnas.1913919116
- Open Access
  An open challenge to advance probabilistic forecasting for dengue epidemics
  Michael A. Johansson, Karyn M. Apfeldorf, Scott Dobson, Jason Devita, Anna L. Buczak, Benjamin Baugher, Linda J. Moniz, Thomas Bagley, Steven M. Babin, Erhan Guven, Teresa K. Yamana, Jeffrey Shaman, Terry Moschou, Nick Lothian, Aaron Lane, Grant Osborne, Gao Jiang, Logan C. Brooks, David C. Farrow, Sangwon Hyun, Ryan J. Tibshirani, Roni Rosenfeld, Justin Lessler, Nicholas G. Reich, Derek A. T. Cummings, Stephen A. Lauer, Sean M. Moore, Hannah E. Clapham, Rachel Lowe, Trevor C. Bailey, Markel García-Díez, Marilia Sá Carvalho, Xavier Rodó, Tridip Sardar, Richard Paul, Evan L. Ray, Krzysztof Sakrejda, Alexandria C. Brown, Xi Meng, Osonde Osoba, Raffaele Vardavas, David Manheim, Melinda Moore, Dhananjai M. Rao, Travis C. Porco, Sarah Ackley, Fengchen Liu, Lee Worden, Matteo Convertino, Yang Liu, Abraham Reddy, Eloy Ortiz, Jorge Rivero, Humberto Brito, Alicia Juarrero, Leah R. Johnson, Robert B. Gramacy, Jeremy M. Cohen, Erin A. Mordecai, Courtney C. Murdock, Jason R. Rohr, Sadie J. Ryan, Anna M. Stewart-Ibarra, Daniel P. Weikel, Antarpreet Jutla, Rakibul Khan, Marissa Poultney, Rita R. Colwell, Brenda Rivera-García, Christopher M. Barker, Jesse E. Bell, Matthew Biggerstaff, David Swerdlow, Luis Mier-y-Teran-Romero, Brett M. Forshey, Juli Trtanj, Jason Asher, Matt Clay, Harold S. Margolis, Andrew M. Hebbeler, Dylan George, and Jean-Paul Chretien
  
  PNAS November 26, 2019 116 (48) 24268-24274; first published November 11, 2019. https://doi.org/10.1073/pnas.1909865116
- Open Access
  Long-term in vivo microscopy of CAR T cell dynamics during eradication of CNS lymphoma in mice
  Matthias Mulazzani, Simon P. Fräßle, Iven von Mücke-Heim, Sigrid Langer, Xiaolan Zhou, Hellen Ishikawa-Ankerhold, Justin Leube, Wenlong Zhang, Sarah Dötsch, Mortimer Svec, Martina Rudelius, Martin Dreyling, Michael von Bergwelt-Baildon, Andreas Straube, Veit R. Buchholz, Dirk H. Busch, and Louisa von Baumgarten
  
  PNAS November 26, 2019 116 (48) 24275-24284; first published November 11, 2019. https://doi.org/10.1073/pnas.1903854116
Microbiology
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  Colorectal cancer-associated microbiota contributes to oncogenic epigenetic signatures
  Iradj Sobhani, Emma Bergsten, Séverine Couffin, Aurélien Amiot, Biba Nebbad, Caroline Barau, Nicola de’Angelis, Sylvie Rabot, Florence Canoui-Poitrine, Denis Mestivier, Thierry Pédron, Khashayarsha Khazaie, and Philippe J. Sansonetti
  
  PNAS November 26, 2019 116 (48) 24285-24295; first published November 11, 2019. https://doi.org/10.1073/pnas.1912129116
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  A DNA virus-encoded immune antagonist fully masks the potent antiviral activity of RNAi in Drosophila
  Alfred W. Bronkhorst, Rob Vogels, Gijs J. Overheul, Bas Pennings, Valérie Gausson-Dorey, Pascal Miesen, and Ronald P. van Rij
  
  PNAS November 26, 2019 116 (48) 24296-24302; first published November 11, 2019. https://doi.org/10.1073/pnas.1909183116
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  Structure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequences
  Jennifer L. Meagher, Matthew Takata, Daniel Gonçalves-Carneiro, Sarah C. Keane, Antoine Rebendenne, Heley Ong, Victoria K. Orr, Margaret R. MacDonald, Jeanne A. Stuckey, Paul D. Bieniasz, and Janet L. Smith
  
  PNAS November 26, 2019 116 (48) 24303-24309; first published November 12, 2019. https://doi.org/10.1073/pnas.1913232116
Neuroscience
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  Hsp110 mitigates α-synuclein pathology in vivo
  Yumiko V. Taguchi, Erica L. Gorenberg, Maria Nagy, Drake Thrasher, Wayne A. Fenton, Laura Volpicelli-Daley, Arthur L. Horwich, and Sreeganga S. Chandra
  
  PNAS November 26, 2019 116 (48) 24310-24316; first published November 4, 2019. https://doi.org/10.1073/pnas.1903268116
- Open Access
  Elovanoids counteract oligomeric β-amyloid-induced gene expression and protect photoreceptors
  Khanh V. Do, Marie-Audrey I. Kautzmann, Bokkyoo Jun, William C. Gordon, Robert Nshimiyimana, Rong Yang, Nicos A. Petasis, and Nicolas G. Bazan
  
  PNAS November 26, 2019 116 (48) 24317-24325; first published November 11, 2019. https://doi.org/10.1073/pnas.1912959116
- Open Access
  Multistable properties of human subthalamic nucleus neurons in Parkinson’s disease
  Jeremy W. Chopek, Hans Hultborn, and Robert M. Brownstone
  
  PNAS November 26, 2019 116 (48) 24326-24333; first published November 11, 2019. https://doi.org/10.1073/pnas.1912128116
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  Accelerated evolution of oligodendrocytes in the human brain
  From the Cover
  
  Stefano Berto, Isabel Mendizabal, Noriyoshi Usui, Kazuya Toriumi, Paramita Chatterjee, Connor Douglas, Carol A. Tamminga, Todd M. Preuss, Soojin V. Yi, and Genevieve Konopka
  
  PNAS November 26, 2019 116 (48) 24334-24342; first published November 11, 2019. https://doi.org/10.1073/pnas.1907982116
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  Hippocampal theta codes for distances in semantic and temporal spaces
  Ethan A. Solomon, Bradley C. Lega, Michael R. Sperling, and Michael J. Kahana
  
  PNAS November 26, 2019 116 (48) 24343-24352; first published November 13, 2019. https://doi.org/10.1073/pnas.1906729116
Pharmacology
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  Distinct effects of orexin receptor antagonist and GABA_A agonist on sleep and physical/cognitive functions after forced awakening
  Jaehoon Seol, Yuya Fujii, Insung Park, Yoko Suzuki, Fusae Kawana, Katsuhiko Yajima, Shoji Fukusumi, Tomohiro Okura, Makoto Satoh, Kumpei Tokuyama, Toshio Kokubo, and Masashi Yanagisawa
  
  PNAS November 26, 2019 116 (48) 24353-24358; first published November 11, 2019. https://doi.org/10.1073/pnas.1907354116
Physiology
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  Pubertal stress recalibration reverses the effects of early life stress in postinstitutionalized children
  Megan R. Gunnar, Carrie E. DePasquale, Brie M. Reid, and Bonny Donzella
  
  PNAS November 26, 2019 116 (48) 23984-23988; first published November 11, 2019. https://doi.org/10.1073/pnas.1909699116
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  Oxidation of methionine residues activates the high-threshold heat-sensitive ion channel TRPV2
  Tabea C. Fricke, Frank Echtermeyer, Johannes Zielke, Jeanne de la Roche, Milos R. Filipovic, Stéphane Claverol, Christine Herzog, Makoto Tominaga, Ruth A. Pumroy, Vera Y. Moiseenkova-Bell, Peter M. Zygmunt, Andreas Leffler, and Mirjam J. Eberhardt
  
  PNAS November 26, 2019 116 (48) 24359-24365; first published November 12, 2019. https://doi.org/10.1073/pnas.1904332116
Population Biology
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  The exacerbation of Ebola outbreaks by conflict in the Democratic Republic of the Congo
  From the Cover
  
  Chad R. Wells, Abhishek Pandey, Martial L. Ndeffo Mbah, Bernard-A. Gaüzère, Denis Malvy, Burton H. Singer, and Alison P. Galvani
  
  PNAS November 26, 2019 116 (48) 24366-24372; first published October 21, 2019. https://doi.org/10.1073/pnas.1913980116
  
  See companion article:
  The DAGs of war
  - Nov 26, 2019

Corrections

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Correction for Zhou et al., Polar molecules catalyze CO insertion into metal-alkyl bonds through the displacement of an agostic C-H bond
PNAS November 26, 2019 116 (48) 24373; first published November 18, 2019. https://doi.org/10.1073/pnas.1918870116
You have access
Correction for Kolitsida et al., Phosphorylation of mitochondrial matrix proteins regulates their selective mitophagic degradation
PNAS November 26, 2019 116 (48) 24374; first published November 18, 2019. https://doi.org/10.1073/pnas.1918594116
You have access
Correction for Reimers et al., Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain
PNAS November 26, 2019 116 (48) 24375; first published November 18, 2019. https://doi.org/10.1073/pnas.1918947116

SI Correction

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Correction to Supporting Information for Lee et al., Cell-type–specific transcriptome and histone modification dynamics during cellular reprogramming in the Arabidopsis stomatal lineage
PNAS November 26, 2019 116 (48) 24376; first published November 18, 2019. https://doi.org/10.1073/pnas.1918946116

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