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Table of Contents
November 26, 2019; vol. 116 no. 48
This Week in PNAS
News Feature
An in-depth look at trending science issues.
- You have accessNews Feature: Gene therapy successes point to better therapies
- Front Matter
Elie Dolgin
Letters
- You have accessThe minimum mean paradox: A mechanical explanation for apparent experiment aversionRobert Mislavsky, Berkeley J. Dietvorst, and Uri SimonsohnPNAS November 26, 2019 116 (48) 23883-23884; first published November 6, 2019. https://doi.org/10.1073/pnas.1912413116
- You have accessReply to Mislavsky et al.: Sometimes people really are averse to experimentsMichelle N. Meyer, Patrick R. Heck, Geoffrey S. Holtzman, Stephen M. Anderson, William Cai, Duncan J. Watts, and Christopher F. ChabrisPNAS November 26, 2019 116 (48) 23885-23886; first published November 12, 2019. https://doi.org/10.1073/pnas.1914509116
See companion article:
- You have accessRainfall regulation of grazed grasslandsMaowei Liang and Elise S. GornishPNAS November 26, 2019 116 (48) 23887-23888; first published October 29, 2019. https://doi.org/10.1073/pnas.1915399116
- You have accessReply to Liang and Gornish: Climate and livestock grazing jointly regulate grassland ecosystem multifunctionalityLing Wang and Deli WangPNAS November 26, 2019 116 (48) 23889-23890; first published October 29, 2019. https://doi.org/10.1073/pnas.1916205116
See companion article:
Brief Report
- Open AccessWEE1 kinase inhibitor AZD1775 induces CDK1 kinase-dependent origin firing in unperturbed G1- and S-phase cellsTatiana N. Moiseeva, Chenao Qian, Norie Sugitani, Hatice U. Osmanbeyoglu, and Christopher J. BakkenistPNAS November 26, 2019 116 (48) 23891-23893; first published November 11, 2019. https://doi.org/10.1073/pnas.1915108116
Physical Sciences
Applied Mathematics
- Open AccessOn the energy efficiency of cell migration in diverse physical environmentsYizeng Li, Lingxing Yao, Yoichiro Mori, and Sean X. SunPNAS November 26, 2019 116 (48) 23894-23900; first published November 12, 2019. https://doi.org/10.1073/pnas.1907625116
Applied Physical Sciences
- You have accessA unified description of hydrophilic and superhydrophobic surfaces in terms of the wetting and drying transitions of liquids
- From the Cover
Robert Evans, Maria C. Stewart, and Nigel B. WildingPNAS November 26, 2019 116 (48) 23901-23908; first published October 14, 2019. https://doi.org/10.1073/pnas.1913587116See companion article:
- Playing the long game wins the cohesion–adhesion rivalry- Nov 26, 2019
- Open AccessCrack engineering for the construction of arbitrary hierarchical architecturesWanbo Li, Miao Yu, Jing Sun, Kentaro Mochizuki, Siyu Chen, Huanxi Zheng, Jiaqian Li, Shuhuai Yao, Hongkai Wu, Beng S. Ong, Satoshi Kawata, Zuankai Wang, and Kangning RenPNAS November 26, 2019 116 (48) 23909-23914; first published November 7, 2019. https://doi.org/10.1073/pnas.1915332116
Chemistry
- You have accessHighly active oxygen evolution integrated with efficient CO2 to CO electroreductionYongtao Meng, Xiao Zhang, Wei-Hsuan Hung, Junkai He, Yi-Sheng Tsai, Yun Kuang, Michael J. Kenney, Jing-Jong Shyue, Yijin Liu, Kevin H. Stone, Xueli Zheng, Steven L. Suib, Meng-Chang Lin, Yongye Liang, and Hongjie DaiPNAS November 26, 2019 116 (48) 23915-23922; first published November 13, 2019. https://doi.org/10.1073/pnas.1915319116
- Open AccessReal-time probing of chirality during a chemical reactionDenitsa Baykusheva, Daniel Zindel, Vít Svoboda, Elias Bommeli, Manuel Ochsner, Andres Tehlar, and Hans Jakob WörnerPNAS November 26, 2019 116 (48) 23923-23929; first published November 13, 2019. https://doi.org/10.1073/pnas.1907189116
Computer Sciences
- Open AccessQuantification of the resilience of primary care networks by stress testing the health care systemDonald Ruggiero Lo Sardo, Stefan Thurner, Johannes Sorger, Georg Duftschmid, Gottfried Endel, and Peter KlimekPNAS November 26, 2019 116 (48) 23930-23935; first published November 11, 2019. https://doi.org/10.1073/pnas.1904826116
Earth, Atmospheric, and Planetary Sciences
- You have accessHeightened levels and seasonal inversion of riverine suspended sediment in a tropical biodiversity hot spot due to artisanal gold miningEvan N. Dethier, Shannon L. Sartain, and David A. LutzPNAS November 26, 2019 116 (48) 23936-23941; first published November 11, 2019. https://doi.org/10.1073/pnas.1907842116
- You have accessNormalized US hurricane damage estimates using area of total destruction, 1900−2018Aslak Grinsted, Peter Ditlevsen, and Jens Hesselbjerg ChristensenPNAS November 26, 2019 116 (48) 23942-23946; first published November 11, 2019. https://doi.org/10.1073/pnas.1912277116
- Open AccessUnraveling driving forces explaining significant reduction in satellite-inferred Arctic surface albedo since the 1980sRudong Zhang, Hailong Wang, Qiang Fu, Philip J. Rasch, and Xuanji WangPNAS November 26, 2019 116 (48) 23947-23953; first published November 11, 2019. https://doi.org/10.1073/pnas.1915258116
Engineering
- You have accessSolvent fluctuations in the solvation shell determine the activation barrier for crystal growth ratesAnish V. Dighe and Meenesh R. SinghPNAS November 26, 2019 116 (48) 23954-23959; first published November 11, 2019. https://doi.org/10.1073/pnas.1910691116
- You have accessMetamaterials with engineered failure load and stiffnessSai Sharan Injeti, Chiara Daraio, and Kaushik BhattacharyaPNAS November 26, 2019 116 (48) 23960-23965; first published November 11, 2019. https://doi.org/10.1073/pnas.1911535116
- You have accessShockley–Queisser triangle predicts the thermodynamic efficiency limits of arbitrarily complex multijunction bifacial solar cellsMuhammad A. Alam and M. Ryyan KhanPNAS November 26, 2019 116 (48) 23966-23971; first published November 12, 2019. https://doi.org/10.1073/pnas.1910745116
- You have accessLabel-free visualization and characterization of extracellular vesicles in breast cancer
- From the Cover
Sixian You, Ronit Barkalifa, Eric J. Chaney, Haohua Tu, Jaena Park, Janet Elise Sorrells, Yi Sun, Yuan-Zhi Liu, Lin Yang, Danny Z. Chen, Marina Marjanovic, Saurabh Sinha, and Stephen A. BoppartPNAS November 26, 2019 116 (48) 24012-24018; first published November 15, 2019. https://doi.org/10.1073/pnas.1909243116
Physics
- You have accessSuperlattice-induced ferroelectricity in charge-ordered La1/3Sr2/3FeO3Se Young Park, Karin M. Rabe, and Jeffrey B. NeatonPNAS November 26, 2019 116 (48) 23972-23976; first published November 11, 2019. https://doi.org/10.1073/pnas.1906513116
- You have accessHow collective asperity detachments nucleate slip at frictional interfacesTom W. J. de Geus, Marko Popović, Wencheng Ji, Alberto Rosso, and Matthieu WyartPNAS November 26, 2019 116 (48) 23977-23983; first published November 7, 2019. https://doi.org/10.1073/pnas.1906551116
Social Sciences
Economic Sciences
- You have accessNormalized US hurricane damage estimates using area of total destruction, 1900−2018Aslak Grinsted, Peter Ditlevsen, and Jens Hesselbjerg ChristensenPNAS November 26, 2019 116 (48) 23942-23946; first published November 11, 2019. https://doi.org/10.1073/pnas.1912277116
Psychological and Cognitive Sciences
- You have accessPubertal stress recalibration reverses the effects of early life stress in postinstitutionalized childrenMegan R. Gunnar, Carrie E. DePasquale, Brie M. Reid, and Bonny DonzellaPNAS November 26, 2019 116 (48) 23984-23988; first published November 11, 2019. https://doi.org/10.1073/pnas.1909699116
- You have accessVeil-of-ignorance reasoning favors the greater goodKaren Huang, Joshua D. Greene, and Max BazermanPNAS November 26, 2019 116 (48) 23989-23995; first published November 12, 2019. https://doi.org/10.1073/pnas.1910125116
- You have accessMaternal prenatal stress phenotypes associate with fetal neurodevelopment and birth outcomes
- From the Cover
Kate Walsh, Clare A. McCormack, Rachel Webster, Anita Pinto, Seonjoo Lee, Tianshu Feng, H. Sloan Krakovsky, Sinclaire M. O’Grady, Benjamin Tycko, Frances A. Champagne, Elizabeth A. Werner, Grace Liu, and Catherine MonkPNAS November 26, 2019 116 (48) 23996-24005; first published October 14, 2019. https://doi.org/10.1073/pnas.1905890116See companion article:
- Stress during pregnancy: Fetal males pay the price- Nov 26, 2019
Social Sciences
- Open AccessQuantification of the resilience of primary care networks by stress testing the health care systemDonald Ruggiero Lo Sardo, Stefan Thurner, Johannes Sorger, Georg Duftschmid, Gottfried Endel, and Peter KlimekPNAS November 26, 2019 116 (48) 23930-23935; first published November 11, 2019. https://doi.org/10.1073/pnas.1904826116
Biological Sciences
Anthropology
- You have accessAssociation of EGLN1 gene with high aerobic capacity of Peruvian Quechua at high altitudeTom D. Brutsaert, Melisa Kiyamu, Gianpietro Elias Revollendo, Jenna L. Isherwood, Frank S. Lee, Maria Rivera-Ch, Fabiola Leon-Velarde, Sudipta Ghosh, and Abigail W. BighamPNAS November 26, 2019 116 (48) 24006-24011; first published November 11, 2019. https://doi.org/10.1073/pnas.1906171116
Applied Biological Sciences
- You have accessLabel-free visualization and characterization of extracellular vesicles in breast cancer
- From the Cover
Sixian You, Ronit Barkalifa, Eric J. Chaney, Haohua Tu, Jaena Park, Janet Elise Sorrells, Yi Sun, Yuan-Zhi Liu, Lin Yang, Danny Z. Chen, Marina Marjanovic, Saurabh Sinha, and Stephen A. BoppartPNAS November 26, 2019 116 (48) 24012-24018; first published November 15, 2019. https://doi.org/10.1073/pnas.1909243116 - You have accessFast fit-free analysis of fluorescence lifetime imaging via deep learningJason T. Smith, Ruoyang Yao, Nattawut Sinsuebphon, Alena Rudkouskaya, Nathan Un, Joseph Mazurkiewicz, Margarida Barroso, Pingkun Yan, and Xavier IntesPNAS November 26, 2019 116 (48) 24019-24030; first published November 12, 2019. https://doi.org/10.1073/pnas.1912707116
Biochemistry
- You have accessRoles of singleton tryptophan motifs in COPI coat stability and vesicle tetheringSophie M. Travis, Bashkim Kokona, Robert Fairman, and Frederick M. HughsonPNAS November 26, 2019 116 (48) 24031-24040; first published November 11, 2019. https://doi.org/10.1073/pnas.1909697116
- You have accessProbing the rice Rubisco–Rubisco activase interaction via subunit heterooligomerizationDevendra Shivhare, Jediael Ng, Yi-Chin Candace Tsai, and Oliver Mueller-CajarPNAS November 26, 2019 116 (48) 24041-24048; first published November 11, 2019. https://doi.org/10.1073/pnas.1914245116
- You have accessSteric complementarity directs sequence promiscuous leader binding in RiPP biosynthesisJonathan R. Chekan, Chayanid Ongpipattanakul, and Satish K. NairPNAS November 26, 2019 116 (48) 24049-24055; first published November 12, 2019. https://doi.org/10.1073/pnas.1908364116
- You have accessStructural studies of the eIF4E–VPg complex reveal a direct competition for capped RNA: Implications for translationLuciana Coutinho de Oliveira, Laurent Volpon, Amanda K. Rahardjo, Michael J. Osborne, Biljana Culjkovic-Kraljacic, Christian Trahan, Marlene Oeffinger, Benjamin H. Kwok, and Katherine L. B. BordenPNAS November 26, 2019 116 (48) 24056-24065; first published November 11, 2019. https://doi.org/10.1073/pnas.1904752116
Biophysics and Computational Biology
- Open AccessIntrinsic elasticity of nucleosomes is encoded by histone variants and calibrated by their binding partnersDaniël P. Melters, Mary Pitman, Tatini Rakshit, Emilios K. Dimitriadis, Minh Bui, Garegin A. Papoian, and Yamini DalalPNAS November 26, 2019 116 (48) 24066-24074; first published November 11, 2019. https://doi.org/10.1073/pnas.1911880116
- Open AccessmRNA structure regulates protein expression through changes in functional half-lifeDavid M. Mauger, B. Joseph Cabral, Vladimir Presnyak, Stephen V. Su, David W. Reid, Brooke Goodman, Kristian Link, Nikhil Khatwani, John Reynders, Melissa J. Moore, and Iain J. McFadyenPNAS November 26, 2019 116 (48) 24075-24083; first published November 11, 2019. https://doi.org/10.1073/pnas.1908052116
Cell Biology
- You have accessT6SS and ExoA of flesh-eating Aeromonas hydrophila in peritonitis and necrotizing fasciitis during mono- and polymicrobial infectionsAna Fernández-Bravo, Paul B. Kilgore, Jourdan A. Andersson, Elizabeth Blears, Maria José Figueras, Nur A. Hasan, Rita R. Colwell, Jian Sha, and Ashok K. ChopraPNAS November 26, 2019 116 (48) 24084-24092; first published November 11, 2019. https://doi.org/10.1073/pnas.1914395116
- You have accessRAMP3 determines rapid recycling of atypical chemokine receptor-3 for guided angiogenesisDuncan I. Mackie, Natalie R. Nielsen, Matthew Harris, Smriti Singh, Reema B. Davis, Danica Dy, Graham Ladds, and Kathleen M. CaronPNAS November 26, 2019 116 (48) 24093-24099; first published November 11, 2019. https://doi.org/10.1073/pnas.1905561116
- Open AccessSingle-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degenerationAndrew P. Voigt, Kelly Mulfaul, Nathaniel K. Mullin, Miles J. Flamme-Wiese, Joseph C. Giacalone, Edwin M. Stone, Budd A. Tucker, Todd E. Scheetz, and Robert F. MullinsPNAS November 26, 2019 116 (48) 24100-24107; first published November 11, 2019. https://doi.org/10.1073/pnas.1914143116
- Open AccessaPKCi triggers basal extrusion of luminal mammary epithelial cells by tuning contractility and vinculin localization at cell junctionsClémentine Villeneuve, Emilie Lagoutte, Ludmilla de Plater, Samuel Mathieu, Jean-Baptiste Manneville, Jean-Léon Maître, Philippe Chavrier, and Carine RosséPNAS November 26, 2019 116 (48) 24108-24114; first published November 7, 2019. https://doi.org/10.1073/pnas.1906779116
Developmental Biology
- You have accessEarly sarcomere and metabolic defects in a zebrafish pitx2c cardiac arrhythmia modelMichelle M. Collins, Gustav Ahlberg, Camilla Vestergaard Hansen, Stefan Guenther, Rubén Marín-Juez, Anna M. Sokol, Hadil El-Sammak, Janett Piesker, Ylva Hellsten, Morten S. Olesen, Didier Y. R. Stainier, and Pia R. LundegaardPNAS November 26, 2019 116 (48) 24115-24121; first published November 8, 2019. https://doi.org/10.1073/pnas.1913905116
- You have accessNeural progenitor cells mediated by H2A.Z.2 regulate microglial development via Cxcl14 in the embryonic brainZhongqiu Li, Yanxin Li, and Jianwei JiaoPNAS November 26, 2019 116 (48) 24122-24132; first published November 11, 2019. https://doi.org/10.1073/pnas.1913978116
- You have accessHepatocyte nuclear factor-1β regulates Wnt signaling through genome-wide competition with β-catenin/lymphoid enhancer binding factorSiu Chiu Chan, Ying Zhang, Marco Pontoglio, and Peter IgarashiPNAS November 26, 2019 116 (48) 24133-24142; first published November 11, 2019. https://doi.org/10.1073/pnas.1909452116
Ecology
- You have accessHeightened levels and seasonal inversion of riverine suspended sediment in a tropical biodiversity hot spot due to artisanal gold miningEvan N. Dethier, Shannon L. Sartain, and David A. LutzPNAS November 26, 2019 116 (48) 23936-23941; first published November 11, 2019. https://doi.org/10.1073/pnas.1907842116
- Open AccessPrey-size plastics are invading larval fish nurseriesJamison M. Gove, Jonathan L. Whitney, Margaret A. McManus, Joey Lecky, Felipe C. Carvalho, Jennifer M. Lynch, Jiwei Li, Philipp Neubauer, Katharine A. Smith, Jana E. Phipps, Donald R. Kobayashi, Karla B. Balagso, Emily A. Contreras, Mark E. Manuel, Mark A. Merrifield, Jeffrey J. Polovina, Gregory P. Asner, Jeffrey A. Maynard, and Gareth J. WilliamsPNAS November 26, 2019 116 (48) 24143-24149; first published November 11, 2019. https://doi.org/10.1073/pnas.1907496116
Evolution
- You have accessIntrogression drives repeated evolution of winter coat color polymorphism in haresIwona Giska, Liliana Farelo, João Pimenta, Fernando A. Seixas, Mafalda S. Ferreira, João P. Marques, Inês Miranda, Jérôme Letty, Hannes Jenny, Klaus Hackländer, Eyðfinn Magnussen, and José Melo-FerreiraPNAS November 26, 2019 116 (48) 24150-24156; first published November 11, 2019. https://doi.org/10.1073/pnas.1910471116
- You have accessSexually antagonistic selection promotes genetic divergence between males and females in an antPierre-André Eyer, Alexander J. Blumenfeld, and Edward L. VargoPNAS November 26, 2019 116 (48) 24157-24163; first published November 12, 2019. https://doi.org/10.1073/pnas.1906568116
- Open AccessHidden resources in the Escherichia coli genome restore PLP synthesis and robust growth after deletion of the essential gene pdxBJuhan Kim, Jake J. Flood, Michael R. Kristofich, Cyrus Gidfar, Andrew B. Morgenthaler, Tobias Fuhrer, Uwe Sauer, Daniel Snyder, Vaughn S. Cooper, Christopher C. Ebmeier, William M. Old, and Shelley D. CopleyPNAS November 26, 2019 116 (48) 24164-24173; first published November 11, 2019. https://doi.org/10.1073/pnas.1915569116
- You have accessParallel evolution of ancient, pleiotropic enhancers underlies butterfly wing pattern mimicryJames J. Lewis, Rachel C. Geltman, Patrick C. Pollak, Kathleen E. Rondem, Steven M. Van Belleghem, Melissa J. Hubisz, Paul R. Munn, Linlin Zhang, Caleb Benson, Anyi Mazo-Vargas, Charles G. Danko, Brian A. Counterman, Riccardo Papa, and Robert D. ReedPNAS November 26, 2019 116 (48) 24174-24183; first published November 11, 2019. https://doi.org/10.1073/pnas.1907068116
Genetics
- Open AccessA set of microRNAs coordinately controls tumorigenesis, invasion, and metastasisIacovos P. Michael, Sadegh Saghafinia, and Douglas HanahanPNAS November 26, 2019 116 (48) 24184-24195; first published November 8, 2019. https://doi.org/10.1073/pnas.1913307116
- You have accessGenomic sites hypersensitive to ultraviolet radiationSanjay Premi, Lynn Han, Sameet Mehta, James Knight, Dejian Zhao, Meg A. Palmatier, Karl Kornacker, and Douglas E. BrashPNAS November 26, 2019 116 (48) 24196-24205; first published November 13, 2019. https://doi.org/10.1073/pnas.1907860116
- Open AccessDefinitive demonstration by synthesis of genome annotation completenessPaul R. Jaschke, Gabrielle A. Dotson, Kay S. Hung, Diane Liu, and Drew EndyPNAS November 26, 2019 116 (48) 24206-24213; first published November 12, 2019. https://doi.org/10.1073/pnas.1905990116
Immunology and Inflammation
- You have accessCRIg plays an essential role in intravascular clearance of bloodborne parasites by interacting with complementGongguan Liu, Yong Fu, Mohammed Yosri, Yanli Chen, Peng Sun, Jinjun Xu, Mingshun Zhang, Donglei Sun, Ashley B. Strickland, Zachary B. Mackey, and Meiqing ShiPNAS November 26, 2019 116 (48) 24214-24220; first published November 13, 2019. https://doi.org/10.1073/pnas.1913443116
- Open AccessNeutrophils promote VLA-4–dependent B cell antigen presentation and accumulation within the meninges during neuroinflammationChelsea R. Parker Harp, Angela S. Archambault, Matthew Cheung, Jesse W. Williams, Rafael S. Czepielewski, Patrick C. Duncker, Aaron J. Kilgore, Aidan T. Miller, Benjamin M. Segal, Alfred H. J. Kim, Gwendalyn J. Randolph, and Gregory F. WuPNAS November 26, 2019 116 (48) 24221-24230; first published November 7, 2019. https://doi.org/10.1073/pnas.1909098116
- Open AccessTrisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivityPaula Araya, Katherine A. Waugh, Kelly D. Sullivan, Nicolás G. Núñez, Emiliano Roselli, Keith P. Smith, Ross E. Granrath, Angela L. Rachubinski, Belinda Enriquez Estrada, Eric T. Butcher, Ross Minter, Kathryn D. Tuttle, Tullia C. Bruno, Mariana Maccioni, and Joaquín M. EspinosaPNAS November 26, 2019 116 (48) 24231-24241; first published November 7, 2019. https://doi.org/10.1073/pnas.1908129116
- Open AccessSingle-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenariansKosuke Hashimoto, Tsukasa Kouno, Tomokatsu Ikawa, Norihito Hayatsu, Yurina Miyajima, Haruka Yabukami, Tommy Terooatea, Takashi Sasaki, Takahiro Suzuki, Matthew Valentine, Giovanni Pascarella, Yasushi Okazaki, Harukazu Suzuki, Jay W. Shin, Aki Minoda, Ichiro Taniuchi, Hideyuki Okano, Yasumichi Arai, Nobuyoshi Hirose, and Piero CarninciPNAS November 26, 2019 116 (48) 24242-24251; first published November 12, 2019. https://doi.org/10.1073/pnas.1907883116
Medical Sciences
- You have accessDysregulation of different classes of tRNA fragments in chronic lymphocytic leukemiaDario Veneziano, Luisa Tomasello, Veronica Balatti, Alexey Palamarchuk, Laura Z. Rassenti, Thomas J. Kipps, Yuri Pekarsky, and Carlo M. CrocePNAS November 26, 2019 116 (48) 24252-24258; first published November 13, 2019. https://doi.org/10.1073/pnas.1913695116
- You have accessMutant p53 antagonizes p63/p73-mediated tumor suppression via Notch1Jin Zhang, Wenqiang Sun, Xiangmudong Kong, Yanhong Zhang, Hee Jung Yang, Cong Ren, Yuqian Jiang, Mingyi Chen, and Xinbin ChenPNAS November 26, 2019 116 (48) 24259-24267; first published November 11, 2019. https://doi.org/10.1073/pnas.1913919116
- Open AccessAn open challenge to advance probabilistic forecasting for dengue epidemicsMichael A. Johansson, Karyn M. Apfeldorf, Scott Dobson, Jason Devita, Anna L. Buczak, Benjamin Baugher, Linda J. Moniz, Thomas Bagley, Steven M. Babin, Erhan Guven, Teresa K. Yamana, Jeffrey Shaman, Terry Moschou, Nick Lothian, Aaron Lane, Grant Osborne, Gao Jiang, Logan C. Brooks, David C. Farrow, Sangwon Hyun, Ryan J. Tibshirani, Roni Rosenfeld, Justin Lessler, Nicholas G. Reich, Derek A. T. Cummings, Stephen A. Lauer, Sean M. Moore, Hannah E. Clapham, Rachel Lowe, Trevor C. Bailey, Markel García-Díez, Marilia Sá Carvalho, Xavier Rodó, Tridip Sardar, Richard Paul, Evan L. Ray, Krzysztof Sakrejda, Alexandria C. Brown, Xi Meng, Osonde Osoba, Raffaele Vardavas, David Manheim, Melinda Moore, Dhananjai M. Rao, Travis C. Porco, Sarah Ackley, Fengchen Liu, Lee Worden, Matteo Convertino, Yang Liu, Abraham Reddy, Eloy Ortiz, Jorge Rivero, Humberto Brito, Alicia Juarrero, Leah R. Johnson, Robert B. Gramacy, Jeremy M. Cohen, Erin A. Mordecai, Courtney C. Murdock, Jason R. Rohr, Sadie J. Ryan, Anna M. Stewart-Ibarra, Daniel P. Weikel, Antarpreet Jutla, Rakibul Khan, Marissa Poultney, Rita R. Colwell, Brenda Rivera-García, Christopher M. Barker, Jesse E. Bell, Matthew Biggerstaff, David Swerdlow, Luis Mier-y-Teran-Romero, Brett M. Forshey, Juli Trtanj, Jason Asher, Matt Clay, Harold S. Margolis, Andrew M. Hebbeler, Dylan George, and Jean-Paul ChretienPNAS November 26, 2019 116 (48) 24268-24274; first published November 11, 2019. https://doi.org/10.1073/pnas.1909865116
- Open AccessLong-term in vivo microscopy of CAR T cell dynamics during eradication of CNS lymphoma in miceMatthias Mulazzani, Simon P. Fräßle, Iven von Mücke-Heim, Sigrid Langer, Xiaolan Zhou, Hellen Ishikawa-Ankerhold, Justin Leube, Wenlong Zhang, Sarah Dötsch, Mortimer Svec, Martina Rudelius, Martin Dreyling, Michael von Bergwelt-Baildon, Andreas Straube, Veit R. Buchholz, Dirk H. Busch, and Louisa von BaumgartenPNAS November 26, 2019 116 (48) 24275-24284; first published November 11, 2019. https://doi.org/10.1073/pnas.1903854116
Microbiology
- You have accessColorectal cancer-associated microbiota contributes to oncogenic epigenetic signaturesIradj Sobhani, Emma Bergsten, Séverine Couffin, Aurélien Amiot, Biba Nebbad, Caroline Barau, Nicola de’Angelis, Sylvie Rabot, Florence Canoui-Poitrine, Denis Mestivier, Thierry Pédron, Khashayarsha Khazaie, and Philippe J. SansonettiPNAS November 26, 2019 116 (48) 24285-24295; first published November 11, 2019. https://doi.org/10.1073/pnas.1912129116
- You have accessA DNA virus-encoded immune antagonist fully masks the potent antiviral activity of RNAi in DrosophilaAlfred W. Bronkhorst, Rob Vogels, Gijs J. Overheul, Bas Pennings, Valérie Gausson-Dorey, Pascal Miesen, and Ronald P. van RijPNAS November 26, 2019 116 (48) 24296-24302; first published November 11, 2019. https://doi.org/10.1073/pnas.1909183116
- You have accessStructure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequencesJennifer L. Meagher, Matthew Takata, Daniel Gonçalves-Carneiro, Sarah C. Keane, Antoine Rebendenne, Heley Ong, Victoria K. Orr, Margaret R. MacDonald, Jeanne A. Stuckey, Paul D. Bieniasz, and Janet L. SmithPNAS November 26, 2019 116 (48) 24303-24309; first published November 12, 2019. https://doi.org/10.1073/pnas.1913232116
Neuroscience
- You have accessHsp110 mitigates α-synuclein pathology in vivoYumiko V. Taguchi, Erica L. Gorenberg, Maria Nagy, Drake Thrasher, Wayne A. Fenton, Laura Volpicelli-Daley, Arthur L. Horwich, and Sreeganga S. ChandraPNAS November 26, 2019 116 (48) 24310-24316; first published November 4, 2019. https://doi.org/10.1073/pnas.1903268116
- Open AccessElovanoids counteract oligomeric β-amyloid-induced gene expression and protect photoreceptorsKhanh V. Do, Marie-Audrey I. Kautzmann, Bokkyoo Jun, William C. Gordon, Robert Nshimiyimana, Rong Yang, Nicos A. Petasis, and Nicolas G. BazanPNAS November 26, 2019 116 (48) 24317-24325; first published November 11, 2019. https://doi.org/10.1073/pnas.1912959116
- Open AccessMultistable properties of human subthalamic nucleus neurons in Parkinson’s diseaseJeremy W. Chopek, Hans Hultborn, and Robert M. BrownstonePNAS November 26, 2019 116 (48) 24326-24333; first published November 11, 2019. https://doi.org/10.1073/pnas.1912128116
- You have accessAccelerated evolution of oligodendrocytes in the human brain
- From the Cover
Stefano Berto, Isabel Mendizabal, Noriyoshi Usui, Kazuya Toriumi, Paramita Chatterjee, Connor Douglas, Carol A. Tamminga, Todd M. Preuss, Soojin V. Yi, and Genevieve KonopkaPNAS November 26, 2019 116 (48) 24334-24342; first published November 11, 2019. https://doi.org/10.1073/pnas.1907982116 - You have accessHippocampal theta codes for distances in semantic and temporal spacesEthan A. Solomon, Bradley C. Lega, Michael R. Sperling, and Michael J. KahanaPNAS November 26, 2019 116 (48) 24343-24352; first published November 13, 2019. https://doi.org/10.1073/pnas.1906729116
Pharmacology
- You have accessDistinct effects of orexin receptor antagonist and GABAA agonist on sleep and physical/cognitive functions after forced awakeningJaehoon Seol, Yuya Fujii, Insung Park, Yoko Suzuki, Fusae Kawana, Katsuhiko Yajima, Shoji Fukusumi, Tomohiro Okura, Makoto Satoh, Kumpei Tokuyama, Toshio Kokubo, and Masashi YanagisawaPNAS November 26, 2019 116 (48) 24353-24358; first published November 11, 2019. https://doi.org/10.1073/pnas.1907354116
Physiology
- You have accessPubertal stress recalibration reverses the effects of early life stress in postinstitutionalized childrenMegan R. Gunnar, Carrie E. DePasquale, Brie M. Reid, and Bonny DonzellaPNAS November 26, 2019 116 (48) 23984-23988; first published November 11, 2019. https://doi.org/10.1073/pnas.1909699116
- You have accessOxidation of methionine residues activates the high-threshold heat-sensitive ion channel TRPV2Tabea C. Fricke, Frank Echtermeyer, Johannes Zielke, Jeanne de la Roche, Milos R. Filipovic, Stéphane Claverol, Christine Herzog, Makoto Tominaga, Ruth A. Pumroy, Vera Y. Moiseenkova-Bell, Peter M. Zygmunt, Andreas Leffler, and Mirjam J. EberhardtPNAS November 26, 2019 116 (48) 24359-24365; first published November 12, 2019. https://doi.org/10.1073/pnas.1904332116
Population Biology
- You have accessThe exacerbation of Ebola outbreaks by conflict in the Democratic Republic of the Congo
- From the Cover
Chad R. Wells, Abhishek Pandey, Martial L. Ndeffo Mbah, Bernard-A. Gaüzère, Denis Malvy, Burton H. Singer, and Alison P. GalvaniPNAS November 26, 2019 116 (48) 24366-24372; first published October 21, 2019. https://doi.org/10.1073/pnas.1913980116See companion article:
- The DAGs of war- Nov 26, 2019
Corrections
- You have accessCorrection for Zhou et al., Polar molecules catalyze CO insertion into metal-alkyl bonds through the displacement of an agostic C-H bondPNAS November 26, 2019 116 (48) 24373; first published November 18, 2019. https://doi.org/10.1073/pnas.1918870116
- You have accessCorrection for Kolitsida et al., Phosphorylation of mitochondrial matrix proteins regulates their selective mitophagic degradationPNAS November 26, 2019 116 (48) 24374; first published November 18, 2019. https://doi.org/10.1073/pnas.1918594116
- You have accessCorrection for Reimers et al., Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle painPNAS November 26, 2019 116 (48) 24375; first published November 18, 2019. https://doi.org/10.1073/pnas.1918947116
SI Correction
- You have accessCorrection to Supporting Information for Lee et al., Cell-type–specific transcriptome and histone modification dynamics during cellular reprogramming in the Arabidopsis stomatal lineagePNAS November 26, 2019 116 (48) 24376; first published November 18, 2019. https://doi.org/10.1073/pnas.1918946116
Commentaries
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