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Research Article

PPARα-targeted mitochondrial bioenergetics mediate repair of intestinal barriers at the host–microbe intersection during SIV infection

View ORCID ProfileKatti R. Crakes, Clarissa Santos Rocha, Irina Grishina, Lauren A. Hirao, Eleonora Napoli, View ORCID ProfileChristopher A. Gaulke, View ORCID ProfileAnne Fenton, Sandipan Datta, Juan Arredondo, Maria L. Marco, Sumathi Sankaran-Walters, Gino Cortopassi, Cecilia Giulivi, and View ORCID ProfileSatya Dandekar
PNAS December 3, 2019 116 (49) 24819-24829; first published November 18, 2019; https://doi.org/10.1073/pnas.1908977116
Katti R. Crakes
aDepartment of Medical Microbiology & Immunology, University of California Davis School of Medicine, Davis, CA 95616;
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  • ORCID record for Katti R. Crakes
Clarissa Santos Rocha
aDepartment of Medical Microbiology & Immunology, University of California Davis School of Medicine, Davis, CA 95616;
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Irina Grishina
aDepartment of Medical Microbiology & Immunology, University of California Davis School of Medicine, Davis, CA 95616;
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Lauren A. Hirao
aDepartment of Medical Microbiology & Immunology, University of California Davis School of Medicine, Davis, CA 95616;
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Eleonora Napoli
bDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616;
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Christopher A. Gaulke
aDepartment of Medical Microbiology & Immunology, University of California Davis School of Medicine, Davis, CA 95616;
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  • ORCID record for Christopher A. Gaulke
Anne Fenton
aDepartment of Medical Microbiology & Immunology, University of California Davis School of Medicine, Davis, CA 95616;
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  • ORCID record for Anne Fenton
Sandipan Datta
bDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616;
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Juan Arredondo
aDepartment of Medical Microbiology & Immunology, University of California Davis School of Medicine, Davis, CA 95616;
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Maria L. Marco
cDepartment of Food Science & Technology, University of California, Davis, CA 95616;
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Sumathi Sankaran-Walters
aDepartment of Medical Microbiology & Immunology, University of California Davis School of Medicine, Davis, CA 95616;
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Gino Cortopassi
bDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616;
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Cecilia Giulivi
bDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616;
dMedical Investigations of Neurodevelopmental Disorders Institute, University of California, Davis, CA 95616
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Satya Dandekar
aDepartment of Medical Microbiology & Immunology, University of California Davis School of Medicine, Davis, CA 95616;
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  • ORCID record for Satya Dandekar
  • For correspondence: sdandekar@ucdavis.edu
  1. Edited by Malcolm A. Martin, National Institutes of Health, Bethesda, MD, and approved October 3, 2019 (received for review May 24, 2019)

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Article Information

vol. 116 no. 49 24819-24829
DOI: 
https://doi.org/10.1073/pnas.1908977116
PubMed: 
31740620

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue December 3, 2019.
  • Published first November 18, 2019.

Article Versions

  • Previous version (November 18, 2019 - 12:03).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
Copyright © 2019 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

Author Information

  1. Katti R. Crakesa,
  2. Clarissa Santos Rochaa,
  3. Irina Grishinaa,
  4. Lauren A. Hiraoa,
  5. Eleonora Napolib,
  6. Christopher A. Gaulkea,1,
  7. Anne Fentona,
  8. Sandipan Dattab,
  9. Juan Arredondoa,
  10. Maria L. Marcoc,
  11. Sumathi Sankaran-Waltersa,
  12. Gino Cortopassib,
  13. Cecilia Giulivib,d, and
  14. Satya Dandekara,2
  1. aDepartment of Medical Microbiology & Immunology, University of California Davis School of Medicine, Davis, CA 95616;
  2. bDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616;
  3. cDepartment of Food Science & Technology, University of California, Davis, CA 95616;
  4. dMedical Investigations of Neurodevelopmental Disorders Institute, University of California, Davis, CA 95616
  1. Edited by Malcolm A. Martin, National Institutes of Health, Bethesda, MD, and approved October 3, 2019 (received for review May 24, 2019)

Footnotes

  • ↵1Present address: Department of Microbiology, Oregon State University, Corvallis, OR 97331.

  • ↵2To whom correspondence may be addressed. Email: sdandekar{at}ucdavis.edu.
  • Author contributions: K.R.C. and S. Dandekar designed research; K.R.C., C.S.R., I.G., L.A.H., C.A.G., A.F., J.A., and S.S.-W. performed research; K.R.C., E.N., S. Datta, M.L.M., G.C., C.G., and S. Dandekar contributed new reagents/analytic tools; K.R.C., C.S.R., I.G., L.A.H., E.N., C.A.G., A.F., S. Datta, M.L.M., S.S.-W., C.G., and S. Dandekar analyzed data; and K.R.C., C.G., and S. Dandekar wrote the paper.

  • The authors declare no competing interest.

  • This article is a PNAS Direct Submission.

  • Data deposition: The data reported in this paper have been deposited in the Gene Expression Omnibus (GEO) database, https://www.ncbi.nlm.nih.gov/geo (accession no. GSE139271) and National Center for Biotechnology Information (NCBI) Bioproject (accession no. PRJNA578916).

  • This article contains supporting information online at https://www.pnas.org/lookup/suppl/doi:10.1073/pnas.1908977116/-/DCSupplemental.

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Jan 20208628189
Feb 202036364103
Mar 20201831685
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PPARα-targeted mitochondrial bioenergetics mediate repair of intestinal barriers at the host–microbe intersection during SIV infection
Katti R. Crakes, Clarissa Santos Rocha, Irina Grishina, Lauren A. Hirao, Eleonora Napoli, Christopher A. Gaulke, Anne Fenton, Sandipan Datta, Juan Arredondo, Maria L. Marco, Sumathi Sankaran-Walters, Gino Cortopassi, Cecilia Giulivi, Satya Dandekar
Proceedings of the National Academy of Sciences Dec 2019, 116 (49) 24819-24829; DOI: 10.1073/pnas.1908977116

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PPARα-targeted mitochondrial bioenergetics mediate repair of intestinal barriers at the host–microbe intersection during SIV infection
Katti R. Crakes, Clarissa Santos Rocha, Irina Grishina, Lauren A. Hirao, Eleonora Napoli, Christopher A. Gaulke, Anne Fenton, Sandipan Datta, Juan Arredondo, Maria L. Marco, Sumathi Sankaran-Walters, Gino Cortopassi, Cecilia Giulivi, Satya Dandekar
Proceedings of the National Academy of Sciences Dec 2019, 116 (49) 24819-24829; DOI: 10.1073/pnas.1908977116
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