PPARα-targeted mitochondrial bioenergetics mediate repair of intestinal barriers at the host–microbe intersection during SIV infection

^aDepartment of Medical Microbiology & Immunology, University of California Davis School of Medicine, Davis, CA 95616;
^bDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616;
^cDepartment of Food Science & Technology, University of California, Davis, CA 95616;
^dMedical Investigations of Neurodevelopmental Disorders Institute, University of California, Davis, CA 95616

Edited by Malcolm A. Martin, National Institutes of Health, Bethesda, MD, and approved October 3, 2019 (received for review May 24, 2019)

Footnotes

↵¹Present address: Department of Microbiology, Oregon State University, Corvallis, OR 97331.
↵²To whom correspondence may be addressed. Email: sdandekar{at}ucdavis.edu.

Author contributions: K.R.C. and S. Dandekar designed research; K.R.C., C.S.R., I.G., L.A.H., C.A.G., A.F., J.A., and S.S.-W. performed research; K.R.C., E.N., S. Datta, M.L.M., G.C., C.G., and S. Dandekar contributed new reagents/analytic tools; K.R.C., C.S.R., I.G., L.A.H., E.N., C.A.G., A.F., S. Datta, M.L.M., S.S.-W., C.G., and S. Dandekar analyzed data; and K.R.C., C.G., and S. Dandekar wrote the paper.
The authors declare no competing interest.
This article is a PNAS Direct Submission.
Data deposition: The data reported in this paper have been deposited in the Gene Expression Omnibus (GEO) database, https://www.ncbi.nlm.nih.gov/geo (accession no. GSE139271) and National Center for Biotechnology Information (NCBI) Bioproject (accession no. PRJNA578916).
This article contains supporting information online at https://www.pnas.org/lookup/suppl/doi:10.1073/pnas.1908977116/-/DCSupplemental.