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Table of Contents

December 26, 2019; vol. 116 no. 52

This Week in PNAS

  • You have access
    In This Issue
    PNAS December 26, 2019 116 (52) 26091-26093; https://doi.org/10.1073/iti5219116

Guest Editor and Reviewer Acknowledgments (Online Only)

  • You have access
    Acknowledgment of Guest Editors, 2019
    PNAS December 26, 2019 116 (52) 26094-26098; https://doi.org/10.1073/pnas.guesteditors116
  • You have access
    Acknowledgment of Reviewers, 2019
    PNAS December 26, 2019 116 (52) 26099-26138; https://doi.org/10.1073/pnas.reviewers116

Opinion

Leading scientists discuss current issues.
  • You have access
    Opinion: Why green “climate gentrification” threatens poor and vulnerable populations
    • Front Matter
    Isabelle Anguelovski, James J. T. Connolly, Hamil Pearsall, Galia Shokry, Melissa Checker, Juliana Maantay, Kenneth Gould, Tammy Lewis, Andrew Maroko, and J. Timmons Roberts
    PNAS December 26, 2019 116 (52) 26139-26143; https://doi.org/10.1073/pnas.1920490117

Profile

  • You have access
    Profile of Dennis L. Kasper
    Jennifer Viegas
    PNAS December 26, 2019 116 (52) 26144-26146; first published December 2, 2019. https://doi.org/10.1073/pnas.1920088116

    See companion article:

    • Symbionts exploit complex signaling to educate the immune system
      - Dec 06, 2019

Commentary

  • You have access
    Toward treatment and cure of epidermolysis bullosa
    Jouni Uitto
    PNAS December 26, 2019 116 (52) 26147-26149; first published December 11, 2019. https://doi.org/10.1073/pnas.1919347117

    See companion article:

    • CRISPR/Cas9-based targeted genome editing for correction of recessive dystrophic epidermolysis bullosa using iPS cells
      - Dec 09, 2019

Letters

  • You have access
    Ca2+/CaM interaction with voltage-gated Na+ channels
    Geoffrey S. Pitt and Seok-Yong Lee
    PNAS December 26, 2019 116 (52) 26150-26151; first published December 3, 2019. https://doi.org/10.1073/pnas.1909835116
  • Open Access
    Reply to Pitt and Lee: Occupancies of Ca2+ in complexes of calmodulin with voltage-gated sodium channels
    Filip Van Petegem and Bernd R. Gardill
    PNAS December 26, 2019 116 (52) 26152; first published December 3, 2019. https://doi.org/10.1073/pnas.1918159116

    See companion article:

    • Crystal structures of Ca2+–calmodulin bound to NaV C-terminal regions suggest role for EF-hand domain in binding and inactivation
      - May 09, 2019
  • You have access
    Urban heating and canopy cover need to be considered as matters of environmental justice
    Michael Drescher
    PNAS December 26, 2019 116 (52) 26153-26154; first published December 17, 2019. https://doi.org/10.1073/pnas.1917213116
  • You have access
    Reply to Drescher: Interdisciplinary collaboration is essential to understand and implement climate-resilient strategies in cities
    Carly D. Ziter, Eric J. Pedersen, Christopher J. Kucharik, and Monica G. Turner
    PNAS December 26, 2019 116 (52) 26155-26156; first published December 17, 2019. https://doi.org/10.1073/pnas.1918746116

    See companion article:

    • Scale-dependent interactions between tree canopy cover and impervious surfaces reduce daytime urban heat during summer
      - Mar 25, 2019

Arthur M. Sackler Colloquium on Using Monkey Models to Understand and Develop Treatments for Human Brain Disorders (Free Online)

  • Introduction

    • You have access
      From basic brain research to treating human brain disorders
      • From the Cover
      Elizabeth A. Buffalo, J. Anthony Movshon, and Robert H. Wurtz
      PNAS December 26, 2019 116 (52) 26167-26172; first published December 23, 2019. https://doi.org/10.1073/pnas.1919895116
  • Colloquium Papers

    • BRAINS AND BEHAVIOR: MICE, MONKEYS AND HUMANS

      • You have access
        Cerebral cortical folding, parcellation, and connectivity in humans, nonhuman primates, and mice
        David C. Van Essen, Chad J. Donahue, Timothy S. Coalson, Henry Kennedy, Takuya Hayashi, and Matthew F. Glasser
        PNAS December 26, 2019 116 (52) 26173-26180; first published December 23, 2019. https://doi.org/10.1073/pnas.1902299116
      • You have access
        Translational implications of the anatomical nonequivalence of functionally equivalent cholinergic circuit motifs
        Anita A. Disney and Jason S. Robert
        PNAS December 26, 2019 116 (52) 26181-26186; first published December 23, 2019. https://doi.org/10.1073/pnas.1902280116
      • You have access
        Attention can be subdivided into neurobiological components corresponding to distinct behavioral effects
        Thomas Zhihao Luo and John H. R. Maunsell
        PNAS December 26, 2019 116 (52) 26187-26194; first published December 23, 2019. https://doi.org/10.1073/pnas.1902286116
      • You have access
        Primate optogenetics: Progress and prognosis
        Yasmine El-Shamayleh and Gregory D. Horwitz
        PNAS December 26, 2019 116 (52) 26195-26203; first published December 23, 2019. https://doi.org/10.1073/pnas.1902284116
    • DISORDERS OF DEVELOPMENT

      • You have access
        Contributions of nonhuman primate research to understanding the consequences of human brain injury during development
        Francesca Cacucci and Faraneh Vargha-Khadem
        PNAS December 26, 2019 116 (52) 26204-26209; first published December 23, 2019. https://doi.org/10.1073/pnas.1912952116
      • You have access
        Nonhuman primate models of hippocampal development and dysfunction
        Jocelyne Bachevalier
        PNAS December 26, 2019 116 (52) 26210-26216; first published December 23, 2019. https://doi.org/10.1073/pnas.1902278116
      • You have access
        Understanding the development of amblyopia using macaque monkey models
        Lynne Kiorpes
        PNAS December 26, 2019 116 (52) 26217-26223; first published December 23, 2019. https://doi.org/10.1073/pnas.1902285116
    • DISORDERS OF AGING

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        Alzheimer’s disease: A clinical perspective and future nonhuman primate research opportunities
        Rafi U. Haque and Allan I. Levey
        PNAS December 26, 2019 116 (52) 26224-26229; first published December 23, 2019. https://doi.org/10.1073/pnas.1912954116
      • You have access
        Alzheimer’s-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer’s disease
        Amy F. T. Arnsten, Dibyadeep Datta, Shannon Leslie, Sheng-Tao Yang, Min Wang, and Angus C. Nairn
        PNAS December 26, 2019 116 (52) 26230-26238; first published December 23, 2019. https://doi.org/10.1073/pnas.1903671116
      • You have access
        Oligomeric Aβ in the monkey brain impacts synaptic integrity and induces accelerated cortical aging
        Danielle Beckman, Sean Ott, Kristine Donis-Cox, William G. Janssen, Eliza Bliss-Moreau, Peter H. Rudebeck, Mark G. Baxter, and John H. Morrison
        PNAS December 26, 2019 116 (52) 26239-26246; first published December 23, 2019. https://doi.org/10.1073/pnas.1902301116
      • You have access
        Experiments in macaque monkeys provide critical insights into age-associated changes in cognitive and sensory function
        Daniel T. Gray and Carol A. Barnes
        PNAS December 26, 2019 116 (52) 26247-26254; first published December 23, 2019. https://doi.org/10.1073/pnas.1902279116
    • RESTORING MOTOR AND SENSORY FUNCTION

      • You have access
        The neurology clinic needs monkey research
        Michael E. Goldberg
        PNAS December 26, 2019 116 (52) 26255-26258; first published December 23, 2019. https://doi.org/10.1073/pnas.1907759116
      • You have access
        Understanding Parkinson’s disease and deep brain stimulation: Role of monkey models
        Jerrold L. Vitek and Luke A. Johnson
        PNAS December 26, 2019 116 (52) 26259-26265; first published December 23, 2019. https://doi.org/10.1073/pnas.1902300116
      • You have access
        Distributed processing of movement signaling
        Scott D. Kennedy and Andrew B. Schwartz
        PNAS December 26, 2019 116 (52) 26266-26273; first published December 23, 2019. https://doi.org/10.1073/pnas.1902296116
      • You have access
        From thought to action: The brain–machine interface in posterior parietal cortex
        Richard A. Andersen, Tyson Aflalo, and Spencer Kellis
        PNAS December 26, 2019 116 (52) 26274-26279; first published December 23, 2019. https://doi.org/10.1073/pnas.1902276116
      • You have access
        The primate model for understanding and restoring vision
        Serge Picaud, Deniz Dalkara, Katia Marazova, Olivier Goureau, Botond Roska, and José-Alain Sahel
        PNAS December 26, 2019 116 (52) 26280-26287; first published December 23, 2019. https://doi.org/10.1073/pnas.1902292116
    • DISORDERS OF MOOD

      • You have access
        From bed to bench side: Reverse translation to optimize neuromodulation for mood disorders
        Peter H. Rudebeck, Erin L. Rich, and Helen S. Mayberg
        PNAS December 26, 2019 116 (52) 26288-26296; first published December 23, 2019. https://doi.org/10.1073/pnas.1902287116
      • You have access
        Why we need nonhuman primates to study the role of ventromedial prefrontal cortex in the regulation of threat- and reward-elicited responses
        Angela C. Roberts and Hannah F. Clarke
        PNAS December 26, 2019 116 (52) 26297-26304; first published December 23, 2019. https://doi.org/10.1073/pnas.1902288116
      • You have access
        The contribution of nonhuman primate research to the understanding of emotion and cognition and its clinical relevance
        Silvia Bernardi and C. Daniel Salzman
        PNAS December 26, 2019 116 (52) 26305-26312; first published December 23, 2019. https://doi.org/10.1073/pnas.1902293116
      • You have access
        Multiple neuronal circuits for variable object–action choices based on short- and long-term memories
        Okihide Hikosaka, Masaharu Yasuda, Kae Nakamura, Masaki Isoda, Hyoung F. Kim, Yasuo Terao, Hidetoshi Amita, and Kazutaka Maeda
        PNAS December 26, 2019 116 (52) 26313-26320; first published December 23, 2019. https://doi.org/10.1073/pnas.1902283116
      • You have access
        The mind–body problem: Circuits that link the cerebral cortex to the adrenal medulla
        Richard P. Dum, David J. Levinthal, and Peter L. Strick
        PNAS December 26, 2019 116 (52) 26321-26328; first published December 23, 2019. https://doi.org/10.1073/pnas.1902297116

Brief Report

  • Open Access
    Reactivation of critical period plasticity in adult auditory cortex through chemogenetic silencing of parvalbumin-positive interneurons
    J. Miguel Cisneros-Franco and Étienne de Villers-Sidani
    PNAS December 26, 2019 116 (52) 26329-26331; first published December 16, 2019. https://doi.org/10.1073/pnas.1913227117

Physical Sciences

  • Applied Mathematics

    • You have access
      A formula for the value of a stochastic game
      Luc Attia and Miquel Oliu-Barton
      PNAS December 26, 2019 116 (52) 26435-26443; first published December 16, 2019. https://doi.org/10.1073/pnas.1908643116
  • Applied Physical Sciences

    • Open Access
      Sono-optogenetics facilitated by a circulation-delivered rechargeable light source for minimally invasive optogenetics
      Xiang Wu, Xingjun Zhu, Paul Chong, Junlang Liu, Louis N. Andre, Kyrstyn S. Ong, Kenneth Brinson Jr, Ali I. Mahdi, Jiachen Li, Lief E. Fenno, Huiliang Wang, and Guosong Hong
      PNAS December 26, 2019 116 (52) 26332-26342; first published December 6, 2019. https://doi.org/10.1073/pnas.1914387116
    • Open Access
      Autonomous bioluminescence imaging of single mammalian cells with the bacterial bioluminescence system
      • From the Cover
      Carola Gregor, Jasmin K. Pape, Klaus C. Gwosch, Tanja Gilat, Steffen J. Sahl, and Stefan W. Hell
      PNAS December 26, 2019 116 (52) 26491-26496; first published December 2, 2019. https://doi.org/10.1073/pnas.1913616116
  • Biophysics and Computational Biology

    • You have access
      Anticipating critical transitions in epithelial–hybrid-mesenchymal cell-fate determination
      Sukanta Sarkar, Sudipta Kumar Sinha, Herbert Levine, Mohit Kumar Jolly, and Partha Sharathi Dutta
      PNAS December 26, 2019 116 (52) 26343-26352; first published December 16, 2019. https://doi.org/10.1073/pnas.1913773116
    • You have access
      Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1
      Petros Giastas, Anastasia Mpakali, Athanasios Papakyriakou, Aggelos Lelis, Paraskevi Kokkala, Margarete Neu, Paul Rowland, John Liddle, Dimitris Georgiadis, and Efstratios Stratikos
      PNAS December 26, 2019 116 (52) 26709-26716; first published December 16, 2019. https://doi.org/10.1073/pnas.1912070116
    • Open Access
      Precise timing is ubiquitous, consistent, and coordinated across a comprehensive, spike-resolved flight motor program
      Joy Putney, Rachel Conn, and Simon Sponberg
      PNAS December 26, 2019 116 (52) 26951-26960; first published December 16, 2019. https://doi.org/10.1073/pnas.1907513116
  • Chemistry

    • You have access
      Steering CO2 electroreduction toward ethanol production by a surface-bound Ru polypyridyl carbene catalyst on N-doped porous carbon
      Yanming Liu, Xinfei Fan, Animesh Nayak, Ying Wang, Bing Shan, Xie Quan, and Thomas J. Meyer
      PNAS December 26, 2019 116 (52) 26353-26358; first published December 10, 2019. https://doi.org/10.1073/pnas.1907740116
    • Open Access
      Nanoscale spectroscopic origins of photoinduced tip–sample force in the midinfrared
      Junghoon Jahng, Eric O. Potma, and Eun Seong Lee
      PNAS December 26, 2019 116 (52) 26359-26366; first published December 11, 2019. https://doi.org/10.1073/pnas.1913729116
  • Computer Sciences

    • Open Access
      Individual structural features constrain the mouse functional connectome
      Francesca Melozzi, Eyal Bergmann, Julie A. Harris, Itamar Kahn, Viktor Jirsa, and Christophe Bernard
      PNAS December 26, 2019 116 (52) 26961-26969; first published December 11, 2019. https://doi.org/10.1073/pnas.1906694116
    • You have access
      Deep learning for inferring gene relationships from single-cell expression data
      Ye Yuan and Ziv Bar-Joseph
      PNAS December 26, 2019 116 (52) 27151-27158; first published December 10, 2019. https://doi.org/10.1073/pnas.1911536116
  • Earth, Atmospheric, and Planetary Sciences

    • Open Access
      Triple junction kinematics accounts for the 2016 Mw 7.8 Kaikoura earthquake rupture complexity
      Xuhua Shi, Paul Tapponnier, Teng Wang, Shengji Wei, Yu Wang, Xin Wang, and Liqing Jiao
      PNAS December 26, 2019 116 (52) 26367-26375; first published December 10, 2019. https://doi.org/10.1073/pnas.1916770116
    • You have access
      Satellite observations reveal extreme methane leakage from a natural gas well blowout
      Sudhanshu Pandey, Ritesh Gautam, Sander Houweling, Hugo Denier van der Gon, Pankaj Sadavarte, Tobias Borsdorff, Otto Hasekamp, Jochen Landgraf, Paul Tol, Tim van Kempen, Ruud Hoogeveen, Richard van Hees, Steven P. Hamburg, Joannes D. Maasakkers, and Ilse Aben
      PNAS December 26, 2019 116 (52) 26376-26381; first published December 16, 2019. https://doi.org/10.1073/pnas.1908712116
    • You have access
      Disappearance of the last tropical glaciers in the Western Pacific Warm Pool (Papua, Indonesia) appears imminent
      Donaldi S. Permana, Lonnie G. Thompson, Ellen Mosley-Thompson, Mary E. Davis, Ping-Nan Lin, Julien P. Nicolas, John F. Bolzan, Broxton W. Bird, Vladimir N. Mikhalenko, Paolo Gabrielli, Victor Zagorodnov, Keith R. Mountain, Ulrich Schotterer, Wido Hanggoro, Muhammad N. Habibie, Yohanes Kaize, Dodo Gunawan, Gesang Setyadi, Raden D. Susanto, Alfonso Fernández, and Bryan G. Mark
      PNAS December 26, 2019 116 (52) 26382-26388; first published December 9, 2019. https://doi.org/10.1073/pnas.1822037116
    • You have access
      Anisotropic diffusion creep in postperovskite provides a new model for deformation at the core−mantle boundary
      David P. Dobson, Alexander Lindsay-Scott, Simon A. Hunt, Edward Bailey, Ian G. Wood, John P. Brodholt, Lidunka Vocadlo, and John Wheeler
      PNAS December 26, 2019 116 (52) 26389-26393; first published December 11, 2019. https://doi.org/10.1073/pnas.1914826116
    • You have access
      Microbial chemolithotrophy mediates oxidative weathering of granitic bedrock
      Stephanie A. Napieralski, Heather L. Buss, Susan L. Brantley, Seungyeol Lee, Huifang Xu, and Eric E. Roden
      PNAS December 26, 2019 116 (52) 26394-26401; first published December 16, 2019. https://doi.org/10.1073/pnas.1909970117
  • Engineering

    • You have access
      Temperature-independent thermal radiation
      Alireza Shahsafi, Patrick Roney, You Zhou, Zhen Zhang, Yuzhe Xiao, Chenghao Wan, Raymond Wambold, Jad Salman, Zhaoning Yu, Jiarui Li, Jerzy T. Sadowski, Riccardo Comin, Shriram Ramanathan, and Mikhail A. Kats
      PNAS December 26, 2019 116 (52) 26402-26406; first published December 17, 2019. https://doi.org/10.1073/pnas.1911244116
    • You have access
      Programmable active kirigami metasheets with more freedom of actuation
      Yichao Tang, Yanbin Li, Yaoye Hong, Shu Yang, and Jie Yin
      PNAS December 26, 2019 116 (52) 26407-26413; first published December 16, 2019. https://doi.org/10.1073/pnas.1906435116
    • Open Access
      Deep learning predicts path-dependent plasticity
      M. Mozaffar, R. Bostanabad, W. Chen, K. Ehmann, J. Cao, and M. A. Bessa
      PNAS December 26, 2019 116 (52) 26414-26420; first published December 16, 2019. https://doi.org/10.1073/pnas.1911815116
    • You have access
      Performance-advantaged ether diesel bioblendstock production by a priori design
      Nabila A. Huq, Xiangchen Huo, Glenn R. Hafenstine, Stephen M. Tifft, Jim Stunkel, Earl D. Christensen, Gina M. Fioroni, Lisa Fouts, Robert L. McCormick, Patrick A. Cherry, Charles S. McEnally, Lisa D. Pfefferle, Matthew R. Wiatrowski, P. Thathiana Benavides, Mary J. Biddy, Raynella M. Connatser, Michael D. Kass, Teresa L. Alleman, Peter C. St. John, Seonah Kim, and Derek R. Vardon
      PNAS December 26, 2019 116 (52) 26421-26430; first published December 16, 2019. https://doi.org/10.1073/pnas.1911107116
  • Physics

    • You have access
      Universal Fermi-surface anisotropy renormalization for interacting Dirac fermions with long-range interactions
      Jia Ning Leaw, Ho-Kin Tang, Maxim Trushin, Fakher F. Assaad, and Shaffique Adam
      PNAS December 26, 2019 116 (52) 26431-26434; first published December 9, 2019. https://doi.org/10.1073/pnas.1913096116
  • Sustainability Science

    • Open Access
      Provincial and sector-level material footprints in China
      Meng Jiang, Paul Behrens, Tao Wang, Zhipeng Tang, Yadong Yu, Dingjiang Chen, Lin Liu, Zijian Ren, Wenji Zhou, Shengjun Zhu, Canfei He, Arnold Tukker, and Bing Zhu
      PNAS December 26, 2019 116 (52) 26484-26490; first published December 16, 2019. https://doi.org/10.1073/pnas.1903028116

Social Sciences

  • Economic Sciences

    • You have access
      A formula for the value of a stochastic game
      Luc Attia and Miquel Oliu-Barton
      PNAS December 26, 2019 116 (52) 26435-26443; first published December 16, 2019. https://doi.org/10.1073/pnas.1908643116
    • Open Access
      Climate variability reduces employment in New England fisheries
      Kimberly L. Oremus
      PNAS December 26, 2019 116 (52) 26444-26449; first published December 9, 2019. https://doi.org/10.1073/pnas.1820154116
  • Environmental Sciences

    • You have access
      Persistent, bioaccumulative, and toxic properties of liquid crystal monomers and their detection in indoor residential dust
      Huijun Su, Shaobo Shi, Ming Zhu, Doug Crump, Robert J. Letcher, John P. Giesy, and Guanyong Su
      PNAS December 26, 2019 116 (52) 26450-26458; first published December 9, 2019. https://doi.org/10.1073/pnas.1915322116
  • Psychological and Cognitive Sciences

    • Open Access
      Social media-predicted personality traits and values can help match people to their ideal jobs
      Margaret L. Kern, Paul X. McCarthy, Deepanjan Chakrabarty, and Marian-Andrei Rizoiu
      PNAS December 26, 2019 116 (52) 26459-26464; first published December 16, 2019. https://doi.org/10.1073/pnas.1917942116
    • You have access
      Ventral hippocampus interacts with prelimbic cortex during inhibition of threat response via learned safety in both mice and humans
      Heidi C. Meyer, Paola Odriozola, Emily M. Cohodes, Jeffrey D. Mandell, Anfei Li, Ruirong Yang, Baila S. Hall, Jason T. Haberman, Sadie J. Zacharek, Conor Liston, Francis S. Lee, and Dylan G. Gee
      PNAS December 26, 2019 116 (52) 26970-26979; first published December 10, 2019. https://doi.org/10.1073/pnas.1910481116
  • Sustainability Science

    • You have access
      A social–ecological analysis of the global agrifood system
      Elisa Oteros-Rozas, Adriana Ruiz-Almeida, Mateo Aguado, José A. González, and Marta G. Rivera-Ferre
      PNAS December 26, 2019 116 (52) 26465-26473; first published December 16, 2019. https://doi.org/10.1073/pnas.1912710116
    • Open Access
      Sixteen years of social and ecological dynamics reveal challenges and opportunities for adaptive management in sustaining the commons
      J. E. Cinner, J. D. Lau, A. G. Bauman, D. A. Feary, F. A. Januchowski-Hartley, C. A. Rojas, M. L. Barnes, B. J. Bergseth, E. Shum, R. Lahari, J. Ben, and N. A. J. Graham
      PNAS December 26, 2019 116 (52) 26474-26483; first published December 16, 2019. https://doi.org/10.1073/pnas.1914812116
    • Open Access
      Provincial and sector-level material footprints in China
      Meng Jiang, Paul Behrens, Tao Wang, Zhipeng Tang, Yadong Yu, Dingjiang Chen, Lin Liu, Zijian Ren, Wenji Zhou, Shengjun Zhu, Canfei He, Arnold Tukker, and Bing Zhu
      PNAS December 26, 2019 116 (52) 26484-26490; first published December 16, 2019. https://doi.org/10.1073/pnas.1903028116

Biological Sciences

  • Biochemistry

    • Open Access
      Autonomous bioluminescence imaging of single mammalian cells with the bacterial bioluminescence system
      • From the Cover
      Carola Gregor, Jasmin K. Pape, Klaus C. Gwosch, Tanja Gilat, Steffen J. Sahl, and Stefan W. Hell
      PNAS December 26, 2019 116 (52) 26491-26496; first published December 2, 2019. https://doi.org/10.1073/pnas.1913616116
    • You have access
      Molybdate pumping into the molybdenum storage protein via an ATP-powered piercing mechanism
      Steffen Brünle, Martin L. Eisinger, Juliane Poppe, Deryck J. Mills, Julian D. Langer, Janet Vonck, and Ulrich Ermler
      PNAS December 26, 2019 116 (52) 26497-26504; first published December 6, 2019. https://doi.org/10.1073/pnas.1913031116
    • You have access
      Combining conservation and species-specific differences to determine how human telomerase binds telomeres
      Valerie M. Tesmer, Eric M. Smith, Oana Danciu, Shilpa Padmanaban, and Jayakrishnan Nandakumar
      PNAS December 26, 2019 116 (52) 26505-26515; first published December 10, 2019. https://doi.org/10.1073/pnas.1911912116
    • Open Access
      The antimicrobial peptide ZY4 combats multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii infection
      James Mwangi, Yizhu Yin, Gan Wang, Min Yang, Ya Li, Zhiye Zhang, and Ren Lai
      PNAS December 26, 2019 116 (52) 26516-26522; first published December 16, 2019. https://doi.org/10.1073/pnas.1909585117
    • Open Access
      Approaching infinite affinity through engineering of peptide–protein interaction
      Anthony H. Keeble, Paula Turkki, Samuel Stokes, Irsyad N. A. Khairil Anuar, Rolle Rahikainen, Vesa P. Hytönen, and Mark Howarth
      PNAS December 26, 2019 116 (52) 26523-26533; first published December 10, 2019. https://doi.org/10.1073/pnas.1909653116
  • Biophysics and Computational Biology

    • You have access
      Anticipating critical transitions in epithelial–hybrid-mesenchymal cell-fate determination
      Sukanta Sarkar, Sudipta Kumar Sinha, Herbert Levine, Mohit Kumar Jolly, and Partha Sharathi Dutta
      PNAS December 26, 2019 116 (52) 26343-26352; first published December 16, 2019. https://doi.org/10.1073/pnas.1913773116
    • Open Access
      Supercoiling DNA optically
      Graeme A. King, Federica Burla, Erwin J. G. Peterman, and Gijs J. L. Wuite
      PNAS December 26, 2019 116 (52) 26534-26539; first published December 5, 2019. https://doi.org/10.1073/pnas.1908826116
    • Open Access
      Defining the remarkable structural malleability of a bacterial surface protein Rib domain implicated in infection
      Fiona Whelan, Aleix Lafita, Samuel C. Griffiths, Rachael E. M. Cooper, Jean L. Whittingham, Johan P. Turkenburg, Iain W. Manfield, Alexander N. St. John, Emanuele Paci, Alex Bateman, and Jennifer R. Potts
      PNAS December 26, 2019 116 (52) 26540-26548; first published December 9, 2019. https://doi.org/10.1073/pnas.1911776116
    • You have access
      Valproic acid interactions with the NavMs voltage-gated sodium channel
      Geancarlo Zanatta, Altin Sula, Andrew J. Miles, Leo C. T. Ng, Rubben Torella, David C. Pryde, Paul G. DeCaen, and B. A. Wallace
      PNAS December 26, 2019 116 (52) 26549-26554; first published December 10, 2019. https://doi.org/10.1073/pnas.1909696116
    • You have access
      Increased stiffness and flow resistance of the inner wall of Schlemm’s canal in glaucomatous human eyes
      Amir Vahabikashi, Ariel Gelman, Biqin Dong, Lihua Gong, Elliott D. K. Cha, Margit Schimmel, Ernst R. Tamm, Kristin Perkumas, W. Daniel Stamer, Cheng Sun, Hao F. Zhang, Haiyan Gong, and Mark Johnson
      PNAS December 26, 2019 116 (52) 26555-26563; first published December 5, 2019. https://doi.org/10.1073/pnas.1911837116
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      Microtubule binding kinetics of membrane-bound kinesin-1 predicts high motor copy numbers on intracellular cargo
      Rui Jiang, Steven Vandal, SooHyun Park, Sheereen Majd, Erkan Tüzel, and William O. Hancock
      PNAS December 26, 2019 116 (52) 26564-26570; first published December 10, 2019. https://doi.org/10.1073/pnas.1916204116
    • You have access
      On the possible origin of protein homochirality, structure, and biochemical function
      Jeffrey Skolnick, Hongyi Zhou, and Mu Gao
      PNAS December 26, 2019 116 (52) 26571-26579; first published December 10, 2019. https://doi.org/10.1073/pnas.1908241116
  • Cell Biology

    • You have access
      Pancreatic cancer organoids recapitulate disease and allow personalized drug screening
      Else Driehuis, Arne van Hoeck, Kat Moore, Sigrid Kolders, Hayley E. Francies, M. Can Gulersonmez, Edwin C. A. Stigter, Boudewijn Burgering, Veerle Geurts, Ana Gracanin, Gergana Bounova, Folkert H. Morsink, Robert Vries, Sylvia Boj, Johan van Es, G. Johan A. Offerhaus, Onno Kranenburg, Mathew J. Garnett, Lodewyk Wessels, Edwin Cuppen, Lodewijk A. A. Brosens, and Hans Clevers
      PNAS December 26, 2019 116 (52) 26580-26590; first published December 9, 2019. https://doi.org/10.1073/pnas.1911273116
    • You have access
      The role of translationally controlled tumor protein in proliferation of Drosophila intestinal stem cells
      Young V. Kwon, Bingqing Zhao, Chiwei Xu, Jiae Lee, Chiao-Lin Chen, Arunachalam Vinayagam, Bruce A. Edgar, and Norbert Perrimon
      PNAS December 26, 2019 116 (52) 26591-26598; first published December 16, 2019. https://doi.org/10.1073/pnas.1910850116
    • You have access
      Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion
      Johan H. van Es, Kay Wiebrands, Carmen López-Iglesias, Marc van de Wetering, Laura Zeinstra, Maaike van den Born, Jeroen Korving, Nobuo Sasaki, Peter J. Peters, Alexander van Oudenaarden, and Hans Clevers
      PNAS December 26, 2019 116 (52) 26599-26605; first published December 16, 2019. https://doi.org/10.1073/pnas.1801888117
    • Open Access
      Loss of p57KIP2 expression confers resistance to contact inhibition in human androgenetic trophoblast stem cells
      Sota Takahashi, Hiroaki Okae, Norio Kobayashi, Akane Kitamura, Kanako Kumada, Nobuo Yaegashi, and Takahiro Arima
      PNAS December 26, 2019 116 (52) 26606-26613; first published December 2, 2019. https://doi.org/10.1073/pnas.1916019116
    • Open Access
      Reactivation of Epstein–Barr virus by a dual-responsive fluorescent EBNA1-targeting agent with Zn2+-chelating function
      Lijun Jiang, Hong Lok Lung, Tao Huang, Rongfeng Lan, Shuai Zha, Lai Sheung Chan, Waygen Thor, Tik-Hung Tsoi, Ho-Fai Chau, Cecilia Boreström, Steven L. Cobb, Sai Wah Tsao, Zhao-Xiang Bian, Ga-Lai Law, Wing-Tak Wong, William Chi-Shing Tai, Wai Yin Chau, Yujun Du, Lucas Hao Xi Tang, Alan Kwok Shing Chiang, Jaap M. Middeldorp, Kwok-Wai Lo, Nai Ki Mak, Nicholas J. Long, and Ka-Leung Wong
      PNAS December 26, 2019 116 (52) 26614-26624; first published December 10, 2019. https://doi.org/10.1073/pnas.1915372116
    • You have access
      SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis
      Kai Su Greene, Michael J. Lukey, Xueying Wang, Bryant Blank, Joseph E. Druso, Miao-chong J. Lin, Clint A. Stalnecker, Chengliang Zhang, Yashira Negrón Abril, Jon W. Erickson, Kristin F. Wilson, Hening Lin, Robert S. Weiss, and Richard A. Cerione
      PNAS December 26, 2019 116 (52) 26625-26632; first published December 16, 2019. https://doi.org/10.1073/pnas.1911954116
    • Open Access
      Peripheral (not central) corneal epithelia contribute to the closure of an annular debridement injury
      Mijeong Park, Alexander Richardson, Elvis Pandzic, Erwin P. Lobo, J. Guy Lyons, and Nick Di Girolamo
      PNAS December 26, 2019 116 (52) 26633-26643; first published December 16, 2019. https://doi.org/10.1073/pnas.1912260116
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      A cis-element within the ARF locus mediates repression of p16INK4A expression via long-range chromatin interactions
      Yang Zhang, Judith Hyle, Shaela Wright, Ying Shao, Xujie Zhao, Hui Zhang, and Chunliang Li
      PNAS December 26, 2019 116 (52) 26644-26652; first published December 9, 2019. https://doi.org/10.1073/pnas.1909720116
  • Ecology

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      Toward a metabolic theory of life history
      Joseph Robert Burger, Chen Hou, and James H. Brown
      PNAS December 26, 2019 116 (52) 26653-26661; first published December 10, 2019. https://doi.org/10.1073/pnas.1907702116
    • You have access
      Modeling active sensing reveals echo detection even in large groups of bats
      Thejasvi Beleyur and Holger R. Goerlitz
      PNAS December 26, 2019 116 (52) 26662-26668; first published December 10, 2019. https://doi.org/10.1073/pnas.1821722116
    • Open Access
      Postreproductive killer whale grandmothers improve the survival of their grandoffspring
      Stuart Nattrass, Darren P. Croft, Samuel Ellis, Michael A. Cant, Michael N. Weiss, Brianna M. Wright, Eva Stredulinsky, Thomas Doniol-Valcroze, John K. B. Ford, Kenneth C. Balcomb, and Daniel W. Franks
      PNAS December 26, 2019 116 (52) 26669-26673; first published December 9, 2019. https://doi.org/10.1073/pnas.1903844116
    • Open Access
      Human activities have opposing effects on distributions of narrow-ranged and widespread plant species in China
      Wu-Bing Xu, Jens-Christian Svenning, Guo-Ke Chen, Ming-Gang Zhang, Ji-Hong Huang, Bin Chen, Alejandro Ordonez, and Ke-Ping Ma
      PNAS December 26, 2019 116 (52) 26674-26681; first published December 16, 2019. https://doi.org/10.1073/pnas.1911851116
    • Open Access
      Resurgence of an apex marine predator and the decline in prey body size
      Jan Ohlberger, Daniel E. Schindler, Eric J. Ward, Timothy E. Walsworth, and Timothy E. Essington
      PNAS December 26, 2019 116 (52) 26682-26689; first published December 16, 2019. https://doi.org/10.1073/pnas.1910930116
  • Environmental Sciences

    • Open Access
      Climate variability reduces employment in New England fisheries
      Kimberly L. Oremus
      PNAS December 26, 2019 116 (52) 26444-26449; first published December 9, 2019. https://doi.org/10.1073/pnas.1820154116
  • Evolution

    • You have access
      Receding ice drove parallel expansions in Southern Ocean penguins
      Theresa L. Cole, Ludovic Dutoit, Nicolas Dussex, Tom Hart, Alana Alexander, Jane L. Younger, Gemma V. Clucas, María José Frugone, Yves Cherel, Richard Cuthbert, Ursula Ellenberg, Steven R. Fiddaman, Johanna Hiscock, David Houston, Pierre Jouventin, Thomas Mattern, Gary Miller, Colin Miskelly, Paul Nolan, Michael J. Polito, Petra Quillfeldt, Peter G. Ryan, Adrian Smith, Alan J. D. Tennyson, David Thompson, Barbara Wienecke, Juliana A. Vianna, and Jonathan M. Waters
      PNAS December 26, 2019 116 (52) 26690-26696; first published December 16, 2019. https://doi.org/10.1073/pnas.1904048116
  • Genetics

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      Gene- and tissue-level interactions in normal gastrointestinal development and Hirschsprung disease
      Sumantra Chatterjee, Priyanka Nandakumar, Dallas R. Auer, Stacey B. Gabriel, and Aravinda Chakravarti
      PNAS December 26, 2019 116 (52) 26697-26708; first published December 9, 2019. https://doi.org/10.1073/pnas.1908756116
  • Immunology and Inflammation

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      Symbionts exploit complex signaling to educate the immune system
      • Inaugural Article
      Deniz Erturk-Hasdemir, Sungwhan F. Oh, Nihal A. Okan, Giuseppe Stefanetti, Francesca S. Gazzaniga, Peter H. Seeberger, Scott E. Plevy, and Dennis L. Kasper
      PNAS December 26, 2019 116 (52) 26157-26166; first published December 6, 2019. https://doi.org/10.1073/pnas.1915978116

      See companion article:

      • Profile of Dennis L. Kasper
        - Dec 02, 2019
    • You have access
      Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1
      Petros Giastas, Anastasia Mpakali, Athanasios Papakyriakou, Aggelos Lelis, Paraskevi Kokkala, Margarete Neu, Paul Rowland, John Liddle, Dimitris Georgiadis, and Efstratios Stratikos
      PNAS December 26, 2019 116 (52) 26709-26716; first published December 16, 2019. https://doi.org/10.1073/pnas.1912070116
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      Neutralization of IL-1α ameliorates Crohn’s disease-like ileitis by functional alterations of the gut microbiome
      Paola Menghini, Daniele Corridoni, Ludovica F. Buttó, Abdullah Osme, Sushma Shivaswamy, Minh Lam, Giorgos Bamias, Theresa T. Pizarro, Alexander Rodriguez-Palacios, Charles A. Dinarello, and Fabio Cominelli
      PNAS December 26, 2019 116 (52) 26717-26726; first published December 16, 2019. https://doi.org/10.1073/pnas.1915043116
    • You have access
      T cell receptor specificity drives accumulation of a reparative population of regulatory T cells within acutely injured skeletal muscle
      Jun Cho, Wilson Kuswanto, Christophe Benoist, and Diane Mathis
      PNAS December 26, 2019 116 (52) 26727-26733; first published December 10, 2019. https://doi.org/10.1073/pnas.1914848116
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      Comprehensive analysis of a mouse model of spontaneous uveoretinitis using single-cell RNA sequencing
      Jacob S. Heng, Sean F. Hackett, Genevieve L. Stein-O’Brien, Briana L. Winer, John Williams, Loyal A. Goff, and Jeremy Nathans
      PNAS December 26, 2019 116 (52) 26734-26744; first published December 16, 2019. https://doi.org/10.1073/pnas.1915571116
    • Open Access
      Affinity maturation in a human humoral response to influenza hemagglutinin
      Kevin R. McCarthy, Donald D. Raymond, Khoi T. Do, Aaron G. Schmidt, and Stephen C. Harrison
      PNAS December 26, 2019 116 (52) 26745-26751; first published December 16, 2019. https://doi.org/10.1073/pnas.1915620116
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      Intermittent rolling is a defect of the extravasation cascade caused by Myosin1e-deficiency in neutrophils
      Eduardo Vadillo, Sandra Chánez-Paredes, Hilda Vargas-Robles, Idaira María Guerrero-Fonseca, Ramón Castellanos-Martínez, Alexander García-Ponce, Porfirio Nava, Daniel Alberto Girón-Pérez, Leopoldo Santos-Argumedo, and Michael Schnoor
      PNAS December 26, 2019 116 (52) 26752-26758; first published December 6, 2019. https://doi.org/10.1073/pnas.1902502116
    • Open Access
      Evolutionary transition from degenerate to nonredundant cytokine signaling networks supporting intrathymic T cell development
      Divine-Fondzenyuy Lawir, Isabell Hess, Katarzyna Sikora, Norimasa Iwanami, Iliana Siamishi, Michael Schorpp, and Thomas Boehm
      PNAS December 26, 2019 116 (52) 26759-26767; first published December 10, 2019. https://doi.org/10.1073/pnas.1915223116
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      Ly49R activation receptor drives self-MHC–educated NK cell immunity against cytomegalovirus infection
      Awndre Gamache, John M. Cronk, William T. Nash, Patryk Puchalski, Alyssa Gillespie, Hairong Wei, Laurie Gray, Marie-Louise Hammarskjold, Wenhao Xu, and Michael G. Brown
      PNAS December 26, 2019 116 (52) 26768-26778; first published December 16, 2019. https://doi.org/10.1073/pnas.1913064117
    • Open Access
      Parent-of-origin differences in DNA methylation of X chromosome genes in T lymphocytes
      • From the Cover
      Lisa C. Golden, Yuichiro Itoh, Noriko Itoh, Sonia Iyengar, Patrick Coit, Youstina Salama, Arthur P. Arnold, Amr H. Sawalha, and Rhonda R. Voskuhl
      PNAS December 26, 2019 116 (52) 26779-26787; first published December 10, 2019. https://doi.org/10.1073/pnas.1910072116
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      Activation-induced cell death of self-reactive regulatory T cells drives autoimmunity
      Ester Badami, Olivier N. F. Cexus, and Sonia Quaratino
      PNAS December 26, 2019 116 (52) 26788-26797; first published December 9, 2019. https://doi.org/10.1073/pnas.1910281116
  • Medical Sciences

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      Characterization of splice-altering mutations in inherited predisposition to cancer
      Silvia Casadei, Suleyman Gulsuner, Brian H. Shirts, Jessica B. Mandell, Hannah M. Kortbawi, Barbara S. Norquist, Elizabeth M. Swisher, Ming K. Lee, Yael Goldberg, Robert O’Connor, Zheng Tan, Colin C. Pritchard, Mary-Claire King, and Tom Walsh
      PNAS December 26, 2019 116 (52) 26798-26807; first published December 16, 2019. https://doi.org/10.1073/pnas.1915608116
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      Oxytocin regulates body composition
      Li Sun, Daria Lizneva, Yaoting Ji, Graziana Colaianni, Elina Hadelia, Anisa Gumerova, Kseniia Ievleva, Tan-Chun Kuo, Funda Korkmaz, Vitaly Ryu, Alina Rahimova, Sakshi Gera, Charit Taneja, Ayesha Khan, Naseer Ahmad, Roberto Tamma, Zhuan Bian, Alberta Zallone, Se-Min Kim, Maria I. New, Jameel Iqbal, Tony Yuen, and Mone Zaidi
      PNAS December 26, 2019 116 (52) 26808-26815; first published December 16, 2019. https://doi.org/10.1073/pnas.1913611116
    • Open Access
      IgGs from patients with amyotrophic lateral sclerosis and diabetes target CaVα2δ1 subunits impairing islet cell function and survival
      Yue Shi, Kyoung Sun Park, Seung Hyun Kim, Jia Yu, Kaixuan Zhao, Lina Yu, Ki Wook Oh, Kayoung Lee, Jaeyoon Kim, Kanchan Chaggar, Yuxin Li, Annette C. Dolphin, William A. Catterall, Sung Ho Ryu, Shao-Nian Yang, and Per-Olof Berggren
      PNAS December 26, 2019 116 (52) 26816-26822; first published December 11, 2019. https://doi.org/10.1073/pnas.1911956116
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      FOXA1 upregulation promotes enhancer and transcriptional reprogramming in endocrine-resistant breast cancer
      Xiaoyong Fu, Resel Pereira, Carmine De Angelis, Jamunarani Veeraraghavan, Sarmistha Nanda, Lanfang Qin, Maria L. Cataldo, Vidyalakshmi Sethunath, Sepideh Mehravaran, Carolina Gutierrez, Gary C. Chamness, Qin Feng, Bert W. O’Malley, Pier Selenica, Britta Weigelt, Jorge S. Reis-Filho, Ofir Cohen, Nikhil Wagle, Agostina Nardone, Rinath Jeselsohn, Myles Brown, Mothaffar F. Rimawi, C. Kent Osborne, and Rachel Schiff
      PNAS December 26, 2019 116 (52) 26823-26834; first published December 11, 2019. https://doi.org/10.1073/pnas.1911584116
    • Open Access
      Epithelial to mesenchymal plasticity and differential response to therapies in pancreatic ductal adenocarcinoma
      Rebecca L. Porter, Neelima K. C. Magnus, Vishal Thapar, Robert Morris, Annamaria Szabolcs, Azfar Neyaz, Anupriya S. Kulkarni, Eric Tai, Abhijit Chougule, Alessandra Hillis, Gabriel Golczer, Hongshan Guo, Teppei Yamada, Tomohiro Kurokawa, Chittampalli Yashaswini, Matteo Ligorio, Kevin D. Vo, Linda Nieman, Andrew S. Liss, Vikram Deshpande, Michael S. Lawrence, Shyamala Maheswaran, Carlos Fernandez-Del Castillo, Theodore S. Hong, David P. Ryan, Peter J. O’Dwyer, Jeffrey A. Drebin, Cristina R. Ferrone, Daniel A. Haber, and David T. Ting
      PNAS December 26, 2019 116 (52) 26835-26845; first published December 16, 2019. https://doi.org/10.1073/pnas.1914915116
    • You have access
      CRISPR/Cas9-based targeted genome editing for correction of recessive dystrophic epidermolysis bullosa using iPS cells
      • From the Cover
      Joanna Jacków, Zongyou Guo, Corey Hansen, Hasan E. Abaci, Yanne S. Doucet, Jung U Shin, Ryota Hayashi, Dominick DeLorenzo, Yudai Kabata, Satoru Shinkuma, Julio C. Salas-Alanis, and Angela M. Christiano
      PNAS December 26, 2019 116 (52) 26846-26852; first published December 9, 2019. https://doi.org/10.1073/pnas.1907081116

      See companion article:

      • Toward treatment and cure of epidermolysis bullosa
        - Dec 11, 2019
    • You have access
      The emergence of classical BSE from atypical/Nor98 scrapie
      Alvina Huor, Juan Carlos Espinosa, Enric Vidal, Hervé Cassard, Jean-Yves Douet, Séverine Lugan, Naima Aron, Alba Marín-Moreno, Patricia Lorenzo, Patricia Aguilar-Calvo, Juan Badiola, Rosa Bolea, Martí Pumarola, Sylvie L. Benestad, Leonore Orge, Alana M. Thackray, Raymond Bujdoso, Juan-Maria Torres, and Olivier Andreoletti
      PNAS December 26, 2019 116 (52) 26853-26862; first published December 16, 2019. https://doi.org/10.1073/pnas.1915737116
    • Open Access
      Extensive subclonal mutational diversity in human colorectal cancer and its significance
      Lawrence A. Loeb, Brendan F. Kohrn, Kaitlyn J. Loubet-Senear, Yasmin J. Dunn, Eun Hyun Ahn, Jacintha N. O’Sullivan, Jesse J. Salk, Mary P. Bronner, and Robert A. Beckman
      PNAS December 26, 2019 116 (52) 26863-26872; first published December 5, 2019. https://doi.org/10.1073/pnas.1910301116
    • You have access
      A tumorigenic index for quantitative analysis of liver cancer initiation and progression
      Gaowei Wang, Xiaolin Luo, Yan Liang, Kota Kaneko, Hairi Li, Xiang-Dong Fu, and Gen-Sheng Feng
      PNAS December 26, 2019 116 (52) 26873-26880; first published December 16, 2019. https://doi.org/10.1073/pnas.1911193116
  • Microbiology

    • You have access
      Evolution of resistance in vitro reveals mechanisms of artemisinin activity in Toxoplasma gondii
      Alex Rosenberg, Madeline R. Luth, Elizabeth A. Winzeler, Michael Behnke, and L. David Sibley
      PNAS December 26, 2019 116 (52) 26881-26891; first published December 5, 2019. https://doi.org/10.1073/pnas.1914732116
    • You have access
      Extracellular electron transfer powers flavinylated extracellular reductases in Gram-positive bacteria
      Samuel H. Light, Raphaël Méheust, Jessica L. Ferrell, Jooyoung Cho, David Deng, Marco Agostoni, Anthony T. Iavarone, Jillian F. Banfield, Sarah E. F. D’Orazio, and Daniel A. Portnoy
      PNAS December 26, 2019 116 (52) 26892-26899; first published December 9, 2019. https://doi.org/10.1073/pnas.1915678116
    • Open Access
      Cross-genotype protection of live-attenuated vaccine candidate for severe fever with thrombocytopenia syndrome virus in a ferret model
      Kwang-Min Yu, Su-Jin Park, Min-Ah Yu, Young-Il Kim, Younho Choi, Jae U. Jung, Benjamin Brennan, and Young Ki Choi
      PNAS December 26, 2019 116 (52) 26900-26908; first published December 9, 2019. https://doi.org/10.1073/pnas.1914704116
    • You have access
      Antitumor astins originate from the fungal endophyte Cyanodermella asteris living within the medicinal plant Aster tataricus
      Thomas Schafhauser, Linda Jahn, Norbert Kirchner, Andreas Kulik, Liane Flor, Alexander Lang, Thibault Caradec, David P. Fewer, Kaarina Sivonen, Willem J. H. van Berkel, Philippe Jacques, Tilmann Weber, Harald Gross, Karl-Heinz van Pée, Wolfgang Wohlleben, and Jutta Ludwig-Müller
      PNAS December 26, 2019 116 (52) 26909-26917; first published December 6, 2019. https://doi.org/10.1073/pnas.1910527116
    • You have access
      A population shift between two heritable cell types of the pathogen Candida albicans is based both on switching and selective proliferation
      Chiraj K. Dalal, Ignacio A. Zuleta, Matthew B. Lohse, Rebecca E. Zordan, Hana El-Samad, and Alexander D. Johnson
      PNAS December 26, 2019 116 (52) 26918-26924; first published December 10, 2019. https://doi.org/10.1073/pnas.1908986116
    • Open Access
      Antimicrobial sensing coupled with cell membrane remodeling mediates antibiotic resistance and virulence in Enterococcus faecalis
      Ayesha Khan, Milya Davlieva, Diana Panesso, Sandra Rincon, William R. Miller, Lorena Diaz, Jinnethe Reyes, Melissa R. Cruz, Orville Pemberton, April H. Nguyen, Sara D. Siegel, Paul J. Planet, Apurva Narechania, Mauricio Latorre, Rafael Rios, Kavindra V. Singh, Hung Ton-That, Danielle A. Garsin, Truc T. Tran, Yousif Shamoo, and Cesar A. Arias
      PNAS December 26, 2019 116 (52) 26925-26932; first published December 9, 2019. https://doi.org/10.1073/pnas.1916037116
    • Open Access
      Viral neutralization by antibody-imposed physical disruption
      Qingbing Zheng, Jie Jiang, Maozhou He, Zizheng Zheng, Hai Yu, Tingting Li, Wenhui Xue, Zimin Tang, Dong Ying, Zekai Li, Shuo Song, Xinlin Liu, Kaihang Wang, Zhiqing Zhang, Daning Wang, Yingbin Wang, Xiaodong Yan, Qinjian Zhao, Jun Zhang, Ying Gu, Shaowei Li, and Ningshao Xia
      PNAS December 26, 2019 116 (52) 26933-26940; first published December 9, 2019. https://doi.org/10.1073/pnas.1916028116
    • You have access
      Inhibition of ULK1 and Beclin1 by an α-herpesvirus Akt-like Ser/Thr kinase limits autophagy to stimulate virus replication
      Rosa M. Rubio and Ian Mohr
      PNAS December 26, 2019 116 (52) 26941-26950; first published December 16, 2019. https://doi.org/10.1073/pnas.1915139116
  • Neuroscience

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      Cerebral cortical folding, parcellation, and connectivity in humans, nonhuman primates, and mice
      David C. Van Essen, Chad J. Donahue, Timothy S. Coalson, Henry Kennedy, Takuya Hayashi, and Matthew F. Glasser
      PNAS December 26, 2019 116 (52) 26173-26180; first published December 23, 2019. https://doi.org/10.1073/pnas.1902299116
    • You have access
      Translational implications of the anatomical nonequivalence of functionally equivalent cholinergic circuit motifs
      Anita A. Disney and Jason S. Robert
      PNAS December 26, 2019 116 (52) 26181-26186; first published December 23, 2019. https://doi.org/10.1073/pnas.1902280116
    • You have access
      Attention can be subdivided into neurobiological components corresponding to distinct behavioral effects
      Thomas Zhihao Luo and John H. R. Maunsell
      PNAS December 26, 2019 116 (52) 26187-26194; first published December 23, 2019. https://doi.org/10.1073/pnas.1902286116
    • You have access
      Primate optogenetics: Progress and prognosis
      Yasmine El-Shamayleh and Gregory D. Horwitz
      PNAS December 26, 2019 116 (52) 26195-26203; first published December 23, 2019. https://doi.org/10.1073/pnas.1902284116
    • You have access
      Nonhuman primate models of hippocampal development and dysfunction
      Jocelyne Bachevalier
      PNAS December 26, 2019 116 (52) 26210-26216; first published December 23, 2019. https://doi.org/10.1073/pnas.1902278116
    • You have access
      Understanding the development of amblyopia using macaque monkey models
      Lynne Kiorpes
      PNAS December 26, 2019 116 (52) 26217-26223; first published December 23, 2019. https://doi.org/10.1073/pnas.1902285116
    • You have access
      Alzheimer’s-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer’s disease
      Amy F. T. Arnsten, Dibyadeep Datta, Shannon Leslie, Sheng-Tao Yang, Min Wang, and Angus C. Nairn
      PNAS December 26, 2019 116 (52) 26230-26238; first published December 23, 2019. https://doi.org/10.1073/pnas.1903671116
    • You have access
      Oligomeric Aβ in the monkey brain impacts synaptic integrity and induces accelerated cortical aging
      Danielle Beckman, Sean Ott, Kristine Donis-Cox, William G. Janssen, Eliza Bliss-Moreau, Peter H. Rudebeck, Mark G. Baxter, and John H. Morrison
      PNAS December 26, 2019 116 (52) 26239-26246; first published December 23, 2019. https://doi.org/10.1073/pnas.1902301116
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      Experiments in macaque monkeys provide critical insights into age-associated changes in cognitive and sensory function
      Daniel T. Gray and Carol A. Barnes
      PNAS December 26, 2019 116 (52) 26247-26254; first published December 23, 2019. https://doi.org/10.1073/pnas.1902279116
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      Understanding Parkinson’s disease and deep brain stimulation: Role of monkey models
      Jerrold L. Vitek and Luke A. Johnson
      PNAS December 26, 2019 116 (52) 26259-26265; first published December 23, 2019. https://doi.org/10.1073/pnas.1902300116
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      Distributed processing of movement signaling
      Scott D. Kennedy and Andrew B. Schwartz
      PNAS December 26, 2019 116 (52) 26266-26273; first published December 23, 2019. https://doi.org/10.1073/pnas.1902296116
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      From thought to action: The brain–machine interface in posterior parietal cortex
      Richard A. Andersen, Tyson Aflalo, and Spencer Kellis
      PNAS December 26, 2019 116 (52) 26274-26279; first published December 23, 2019. https://doi.org/10.1073/pnas.1902276116
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      The primate model for understanding and restoring vision
      Serge Picaud, Deniz Dalkara, Katia Marazova, Olivier Goureau, Botond Roska, and José-Alain Sahel
      PNAS December 26, 2019 116 (52) 26280-26287; first published December 23, 2019. https://doi.org/10.1073/pnas.1902292116
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      Why we need nonhuman primates to study the role of ventromedial prefrontal cortex in the regulation of threat- and reward-elicited responses
      Angela C. Roberts and Hannah F. Clarke
      PNAS December 26, 2019 116 (52) 26297-26304; first published December 23, 2019. https://doi.org/10.1073/pnas.1902288116
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      The contribution of nonhuman primate research to the understanding of emotion and cognition and its clinical relevance
      Silvia Bernardi and C. Daniel Salzman
      PNAS December 26, 2019 116 (52) 26305-26312; first published December 23, 2019. https://doi.org/10.1073/pnas.1902293116
    • You have access
      Multiple neuronal circuits for variable object–action choices based on short- and long-term memories
      Okihide Hikosaka, Masaharu Yasuda, Kae Nakamura, Masaki Isoda, Hyoung F. Kim, Yasuo Terao, Hidetoshi Amita, and Kazutaka Maeda
      PNAS December 26, 2019 116 (52) 26313-26320; first published December 23, 2019. https://doi.org/10.1073/pnas.1902283116
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      The mind–body problem: Circuits that link the cerebral cortex to the adrenal medulla
      Richard P. Dum, David J. Levinthal, and Peter L. Strick
      PNAS December 26, 2019 116 (52) 26321-26328; first published December 23, 2019. https://doi.org/10.1073/pnas.1902297116
    • Open Access
      Precise timing is ubiquitous, consistent, and coordinated across a comprehensive, spike-resolved flight motor program
      Joy Putney, Rachel Conn, and Simon Sponberg
      PNAS December 26, 2019 116 (52) 26951-26960; first published December 16, 2019. https://doi.org/10.1073/pnas.1907513116
    • Open Access
      Individual structural features constrain the mouse functional connectome
      Francesca Melozzi, Eyal Bergmann, Julie A. Harris, Itamar Kahn, Viktor Jirsa, and Christophe Bernard
      PNAS December 26, 2019 116 (52) 26961-26969; first published December 11, 2019. https://doi.org/10.1073/pnas.1906694116
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      Ventral hippocampus interacts with prelimbic cortex during inhibition of threat response via learned safety in both mice and humans
      Heidi C. Meyer, Paola Odriozola, Emily M. Cohodes, Jeffrey D. Mandell, Anfei Li, Ruirong Yang, Baila S. Hall, Jason T. Haberman, Sadie J. Zacharek, Conor Liston, Francis S. Lee, and Dylan G. Gee
      PNAS December 26, 2019 116 (52) 26970-26979; first published December 10, 2019. https://doi.org/10.1073/pnas.1910481116
    • Open Access
      Molecular profiling of single neurons of known identity in two ganglia from the crab Cancer borealis
      Adam J. Northcutt, Daniel R. Kick, Adriane G. Otopalik, Benjamin M. Goetz, Rayna M. Harris, Joseph M. Santin, Hans A. Hofmann, Eve Marder, and David J. Schulz
      PNAS December 26, 2019 116 (52) 26980-26990; first published December 5, 2019. https://doi.org/10.1073/pnas.1911413116
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      The network architecture of rat intrinsic interbrain (diencephalic) macroconnections
      Larry W. Swanson, Olaf Sporns, and Joel D. Hahn
      PNAS December 26, 2019 116 (52) 26991-27000; first published December 5, 2019. https://doi.org/10.1073/pnas.1915446116
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      Sources of off-target expression from recombinase-dependent AAV vectors and mitigation with cross-over insensitive ATG-out vectors
      Kyle B. Fischer, Hannah K. Collins, and Edward M. Callaway
      PNAS December 26, 2019 116 (52) 27001-27010; first published December 16, 2019. https://doi.org/10.1073/pnas.1915974116
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      Synaptic control of spinal GRPR+ neurons by local and long-range inhibitory inputs
      Ming-Zhe Liu, Xiao-Jun Chen, Tong-Yu Liang, Qing Li, Meng Wang, Xin-Yan Zhang, Yu-Zhuo Li, Qiang Sun, and Yan-Gang Sun
      PNAS December 26, 2019 116 (52) 27011-27017; first published December 5, 2019. https://doi.org/10.1073/pnas.1905658116
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      Second-order cues to figure motion enable object detection during prey capture by praying mantises
      Vivek Nityananda, James O’Keeffe, Diana Umeton, Adam Simmons, and Jenny C. A. Read
      PNAS December 26, 2019 116 (52) 27018-27027; first published December 9, 2019. https://doi.org/10.1073/pnas.1912310116
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      5-HT2A receptor activation normalizes stress-induced dysregulation of GABAergic signaling in the ventral tegmental area
      Blake A. Kimmey, Alexey Ostroumov, and John A. Dani
      PNAS December 26, 2019 116 (52) 27028-27034; first published December 5, 2019. https://doi.org/10.1073/pnas.1911446116
    • Open Access
      Position–theta-phase model of hippocampal place cell activity applied to quantification of running speed modulation of firing rate
      Kathryn McClain, David Tingley, David J. Heeger, and György Buzsáki
      PNAS December 26, 2019 116 (52) 27035-27042; first published December 16, 2019. https://doi.org/10.1073/pnas.1912792116
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      Photoreceptor disc membranes are formed through an Arp2/3-dependent lamellipodium-like mechanism
      William J. Spencer, Tylor R. Lewis, Sebastien Phan, Martha A. Cady, Ekaterina O. Serebrovskaya, Nicholas F. Schneider, Keun-Young Kim, Lisa A. Cameron, Nikolai P. Skiba, Mark H. Ellisman, and Vadim Y. Arshavsky
      PNAS December 26, 2019 116 (52) 27043-27052; first published December 16, 2019. https://doi.org/10.1073/pnas.1913518117
    • Open Access
      A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism
      Marcus Davidsson, Gang Wang, Patrick Aldrin-Kirk, Tiago Cardoso, Sara Nolbrant, Morgan Hartnor, Janitha Mudannayake, Malin Parmar, and Tomas Björklund
      PNAS December 26, 2019 116 (52) 27053-27062; first published December 9, 2019. https://doi.org/10.1073/pnas.1910061116
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      Perineuronal nets protect long-term memory by limiting activity-dependent inhibition from parvalbumin interneurons
      Wei Shi, Xiangbo Wei, Xiaofei Wang, Shuwen Du, Weixuan Liu, Jian Song, and Yun Wang
      PNAS December 26, 2019 116 (52) 27063-27073; first published December 16, 2019. https://doi.org/10.1073/pnas.1902680116
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      Evoked potentials as a biomarker of remyelination
      Moones Heidari, Abigail B. Radcliff, Gillian J. McLellan, James N. Ver Hoeve, Kore Chan, Julie A. Kiland, Nicholas S. Keuler, Benjamin K. August, Dylan Sebo, Aaron S. Field, and Ian D. Duncan
      PNAS December 26, 2019 116 (52) 27074-27083; first published December 16, 2019. https://doi.org/10.1073/pnas.1906358116
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      Descending projections from the substantia nigra pars reticulata differentially control seizures
      Evan Wicker, Veronica C. Beck, Colin Kulick-Soper, Catherine V. Kulick-Soper, Safwan K. Hyder, Carolina Campos-Rodriguez, Tahiyana Khan, Prosper N’Gouemo, and Patrick A. Forcelli
      PNAS December 26, 2019 116 (52) 27084-27094; first published December 16, 2019. https://doi.org/10.1073/pnas.1908176117
  • Physiology

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      SUMO1 modification of PKD2 channels regulates arterial contractility
      Raquibul Hasan, M. Dennis Leo, Padmapriya Muralidharan, Alejandro Mata-Daboin, Wen Yin, Simon Bulley, Carlos Fernandez-Peña, Charles E. MacKay, and Jonathan H. Jaggar
      PNAS December 26, 2019 116 (52) 27095-27104; first published December 10, 2019. https://doi.org/10.1073/pnas.1917264116
  • Plant Biology

    • Open Access
      A noncanonical vacuolar sugar transferase required for biosynthesis of antimicrobial defense compounds in oat
      Anastasia Orme, Thomas Louveau, Michael J. Stephenson, Ingo Appelhagen, Rachel Melton, Jitender Cheema, Yan Li, Qiang Zhao, Lei Zhang, Danlin Fan, Qilin Tian, Robert J. Vickerstaff, Tim Langdon, Bin Han, and Anne Osbourn
      PNAS December 26, 2019 116 (52) 27105-27114; first published December 5, 2019. https://doi.org/10.1073/pnas.1914652116
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      The γ-tubulin complex protein GCP6 is crucial for spindle morphogenesis but not essential for microtubule reorganization in Arabidopsis
      Huiying Miao, Rongfang Guo, Junlin Chen, Qiaomei Wang, Yuh-Ru Julie Lee, and Bo Liu
      PNAS December 26, 2019 116 (52) 27115-27123; first published December 9, 2019. https://doi.org/10.1073/pnas.1912240116
    • Open Access
      Transcriptomic analysis of field-droughted sorghum from seedling to maturity reveals biotic and metabolic responses
      Nelle Varoquaux, Benjamin Cole, Cheng Gao, Grady Pierroz, Christopher R. Baker, Dhruv Patel, Mary Madera, Tim Jeffers, Joy Hollingsworth, Julie Sievert, Yuko Yoshinaga, Judith A. Owiti, Vasanth R. Singan, Stephanie DeGraaf, Ling Xu, Matthew J. Blow, Maria J. Harrison, Axel Visel, Christer Jansson, Krishna K. Niyogi, Robert Hutmacher, Devin Coleman-Derr, Ronan C. O’Malley, John W. Taylor, Jeffery Dahlberg, John P. Vogel, Peggy G. Lemaux, and Elizabeth Purdom
      PNAS December 26, 2019 116 (52) 27124-27132; first published December 5, 2019. https://doi.org/10.1073/pnas.1907500116
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      Cryptochrome 2 competes with COP1 substrates to repress COP1 ubiquitin ligase activity during Arabidopsis photomorphogenesis
      Jathish Ponnu, Tabea Riedel, Eva Penner, Andrea Schrader, and Ute Hoecker
      PNAS December 26, 2019 116 (52) 27133-27141; first published December 10, 2019. https://doi.org/10.1073/pnas.1909181116
  • Population Biology

    • Open Access
      Virus–virus interactions impact the population dynamics of influenza and the common cold
      Sema Nickbakhsh, Colette Mair, Louise Matthews, Richard Reeve, Paul C. D. Johnson, Fiona Thorburn, Beatrix von Wissmann, Arlene Reynolds, James McMenamin, Rory N. Gunson, and Pablo R. Murcia
      PNAS December 26, 2019 116 (52) 27142-27150; first published December 16, 2019. https://doi.org/10.1073/pnas.1911083116

      See companion article:

      • Reply to Kloepfer and Gern: Independent studies suggest an arms race between influenza and rhinovirus: What next?
        - Mar 03, 2020
  • Sustainability Science

    • Open Access
      Sixteen years of social and ecological dynamics reveal challenges and opportunities for adaptive management in sustaining the commons
      J. E. Cinner, J. D. Lau, A. G. Bauman, D. A. Feary, F. A. Januchowski-Hartley, C. A. Rojas, M. L. Barnes, B. J. Bergseth, E. Shum, R. Lahari, J. Ben, and N. A. J. Graham
      PNAS December 26, 2019 116 (52) 26474-26483; first published December 16, 2019. https://doi.org/10.1073/pnas.1914812116
  • Systems Biology

    • You have access
      Deep learning for inferring gene relationships from single-cell expression data
      Ye Yuan and Ziv Bar-Joseph
      PNAS December 26, 2019 116 (52) 27151-27158; first published December 10, 2019. https://doi.org/10.1073/pnas.1911536116

Corrections

  • You have access
    Correction for Kumra et al., Fibulin-4 exerts a dual role in LTBP-4L–mediated matrix assembly and function
    PNAS December 26, 2019 116 (52) 27159; first published December 16, 2019. https://doi.org/10.1073/pnas.1920843117
  • You have access
    Correction for Fan et al., Abscisic acid regulation of guard-cell K+ and anion channels in Gβ- and RGS-deficient Arabidopsis lines
    PNAS December 26, 2019 116 (52) 27160-27161; first published December 23, 2019. https://doi.org/10.1073/pnas.1920065116
  • You have access
    Correction for de la Cuesta et al., Oil and aid revenue produce equal demands for accountability as taxes in Ghana and Uganda
    PNAS December 26, 2019 116 (52) 27162; first published December 16, 2019. https://doi.org/10.1073/pnas.1920067116
  • You have access
    Correction for Duckworth et al., Cognitive and noncognitive predictors of success
    PNAS December 26, 2019 116 (52) 27163; first published December 16, 2019. https://doi.org/10.1073/pnas.1920625117
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Proceedings of the National Academy of Sciences: 116 (52)
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