Proceedings of the National Academy of Sciences: 116 (52)

New Research In

December 26, 2019; vol. 116 no. 52

This Week in PNAS

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In This Issue
PNAS December 26, 2019 116 (52) 26091-26093; https://doi.org/10.1073/iti5219116

Guest Editor and Reviewer Acknowledgments (Online Only)

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Acknowledgment of Guest Editors, 2019
PNAS December 26, 2019 116 (52) 26094-26098; https://doi.org/10.1073/pnas.guesteditors116
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Acknowledgment of Reviewers, 2019
PNAS December 26, 2019 116 (52) 26099-26138; https://doi.org/10.1073/pnas.reviewers116

Opinion

Leading scientists discuss current issues.

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Opinion: Why green “climate gentrification” threatens poor and vulnerable populations
Front Matter
Isabelle Anguelovski, James J. T. Connolly, Hamil Pearsall, Galia Shokry, Melissa Checker, Juliana Maantay, Kenneth Gould, Tammy Lewis, Andrew Maroko, and J. Timmons Roberts

PNAS December 26, 2019 116 (52) 26139-26143; https://doi.org/10.1073/pnas.1920490117

Profile

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Profile of Dennis L. Kasper
Jennifer Viegas

PNAS December 26, 2019 116 (52) 26144-26146; first published December 2, 2019. https://doi.org/10.1073/pnas.1920088116
See companion article:
Symbionts exploit complex signaling to educate the immune system
- Dec 06, 2019

Commentary

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Toward treatment and cure of epidermolysis bullosa
Jouni Uitto

PNAS December 26, 2019 116 (52) 26147-26149; first published December 11, 2019. https://doi.org/10.1073/pnas.1919347117
See companion article:
CRISPR/Cas9-based targeted genome editing for correction of recessive dystrophic epidermolysis bullosa using iPS cells
- Dec 09, 2019

Letters

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Ca²⁺/CaM interaction with voltage-gated Na⁺ channels
Geoffrey S. Pitt and Seok-Yong Lee

PNAS December 26, 2019 116 (52) 26150-26151; first published December 3, 2019. https://doi.org/10.1073/pnas.1909835116
Open Access
Reply to Pitt and Lee: Occupancies of Ca²⁺ in complexes of calmodulin with voltage-gated sodium channels
Filip Van Petegem and Bernd R. Gardill

PNAS December 26, 2019 116 (52) 26152; first published December 3, 2019. https://doi.org/10.1073/pnas.1918159116
See companion article:
Crystal structures of Ca²⁺–calmodulin bound to Na_V C-terminal regions suggest role for EF-hand domain in binding and inactivation
- May 09, 2019
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Urban heating and canopy cover need to be considered as matters of environmental justice
Michael Drescher

PNAS December 26, 2019 116 (52) 26153-26154; first published December 17, 2019. https://doi.org/10.1073/pnas.1917213116
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Reply to Drescher: Interdisciplinary collaboration is essential to understand and implement climate-resilient strategies in cities
Carly D. Ziter, Eric J. Pedersen, Christopher J. Kucharik, and Monica G. Turner

PNAS December 26, 2019 116 (52) 26155-26156; first published December 17, 2019. https://doi.org/10.1073/pnas.1918746116
See companion article:
Scale-dependent interactions between tree canopy cover and impervious surfaces reduce daytime urban heat during summer
- Mar 25, 2019

Arthur M. Sackler Colloquium on Using Monkey Models to Understand and Develop Treatments for Human Brain Disorders (Free Online)

Introduction
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  From basic brain research to treating human brain disorders
  From the Cover
  
  Elizabeth A. Buffalo, J. Anthony Movshon, and Robert H. Wurtz
  
  PNAS December 26, 2019 116 (52) 26167-26172; first published December 23, 2019. https://doi.org/10.1073/pnas.1919895116
Colloquium Papers
- BRAINS AND BEHAVIOR: MICE, MONKEYS AND HUMANS
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    Cerebral cortical folding, parcellation, and connectivity in humans, nonhuman primates, and mice
    David C. Van Essen, Chad J. Donahue, Timothy S. Coalson, Henry Kennedy, Takuya Hayashi, and Matthew F. Glasser
    
    PNAS December 26, 2019 116 (52) 26173-26180; first published December 23, 2019. https://doi.org/10.1073/pnas.1902299116
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    Translational implications of the anatomical nonequivalence of functionally equivalent cholinergic circuit motifs
    Anita A. Disney and Jason S. Robert
    
    PNAS December 26, 2019 116 (52) 26181-26186; first published December 23, 2019. https://doi.org/10.1073/pnas.1902280116
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    Attention can be subdivided into neurobiological components corresponding to distinct behavioral effects
    Thomas Zhihao Luo and John H. R. Maunsell
    
    PNAS December 26, 2019 116 (52) 26187-26194; first published December 23, 2019. https://doi.org/10.1073/pnas.1902286116
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    Primate optogenetics: Progress and prognosis
    Yasmine El-Shamayleh and Gregory D. Horwitz
    
    PNAS December 26, 2019 116 (52) 26195-26203; first published December 23, 2019. https://doi.org/10.1073/pnas.1902284116
- DISORDERS OF DEVELOPMENT
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    Contributions of nonhuman primate research to understanding the consequences of human brain injury during development
    Francesca Cacucci and Faraneh Vargha-Khadem
    
    PNAS December 26, 2019 116 (52) 26204-26209; first published December 23, 2019. https://doi.org/10.1073/pnas.1912952116
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    Nonhuman primate models of hippocampal development and dysfunction
    Jocelyne Bachevalier
    
    PNAS December 26, 2019 116 (52) 26210-26216; first published December 23, 2019. https://doi.org/10.1073/pnas.1902278116
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    Understanding the development of amblyopia using macaque monkey models
    Lynne Kiorpes
    
    PNAS December 26, 2019 116 (52) 26217-26223; first published December 23, 2019. https://doi.org/10.1073/pnas.1902285116
- DISORDERS OF AGING
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    Alzheimer’s disease: A clinical perspective and future nonhuman primate research opportunities
    Rafi U. Haque and Allan I. Levey
    
    PNAS December 26, 2019 116 (52) 26224-26229; first published December 23, 2019. https://doi.org/10.1073/pnas.1912954116
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    Alzheimer’s-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer’s disease
    Amy F. T. Arnsten, Dibyadeep Datta, Shannon Leslie, Sheng-Tao Yang, Min Wang, and Angus C. Nairn
    
    PNAS December 26, 2019 116 (52) 26230-26238; first published December 23, 2019. https://doi.org/10.1073/pnas.1903671116
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    Oligomeric Aβ in the monkey brain impacts synaptic integrity and induces accelerated cortical aging
    Danielle Beckman, Sean Ott, Kristine Donis-Cox, William G. Janssen, Eliza Bliss-Moreau, Peter H. Rudebeck, Mark G. Baxter, and John H. Morrison
    
    PNAS December 26, 2019 116 (52) 26239-26246; first published December 23, 2019. https://doi.org/10.1073/pnas.1902301116
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    Experiments in macaque monkeys provide critical insights into age-associated changes in cognitive and sensory function
    Daniel T. Gray and Carol A. Barnes
    
    PNAS December 26, 2019 116 (52) 26247-26254; first published December 23, 2019. https://doi.org/10.1073/pnas.1902279116
- RESTORING MOTOR AND SENSORY FUNCTION
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    The neurology clinic needs monkey research
    Michael E. Goldberg
    
    PNAS December 26, 2019 116 (52) 26255-26258; first published December 23, 2019. https://doi.org/10.1073/pnas.1907759116
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    Understanding Parkinson’s disease and deep brain stimulation: Role of monkey models
    Jerrold L. Vitek and Luke A. Johnson
    
    PNAS December 26, 2019 116 (52) 26259-26265; first published December 23, 2019. https://doi.org/10.1073/pnas.1902300116
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    Distributed processing of movement signaling
    Scott D. Kennedy and Andrew B. Schwartz
    
    PNAS December 26, 2019 116 (52) 26266-26273; first published December 23, 2019. https://doi.org/10.1073/pnas.1902296116
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    From thought to action: The brain–machine interface in posterior parietal cortex
    Richard A. Andersen, Tyson Aflalo, and Spencer Kellis
    
    PNAS December 26, 2019 116 (52) 26274-26279; first published December 23, 2019. https://doi.org/10.1073/pnas.1902276116
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    The primate model for understanding and restoring vision
    Serge Picaud, Deniz Dalkara, Katia Marazova, Olivier Goureau, Botond Roska, and José-Alain Sahel
    
    PNAS December 26, 2019 116 (52) 26280-26287; first published December 23, 2019. https://doi.org/10.1073/pnas.1902292116
- DISORDERS OF MOOD
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    From bed to bench side: Reverse translation to optimize neuromodulation for mood disorders
    Peter H. Rudebeck, Erin L. Rich, and Helen S. Mayberg
    
    PNAS December 26, 2019 116 (52) 26288-26296; first published December 23, 2019. https://doi.org/10.1073/pnas.1902287116
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    Why we need nonhuman primates to study the role of ventromedial prefrontal cortex in the regulation of threat- and reward-elicited responses
    Angela C. Roberts and Hannah F. Clarke
    
    PNAS December 26, 2019 116 (52) 26297-26304; first published December 23, 2019. https://doi.org/10.1073/pnas.1902288116
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    The contribution of nonhuman primate research to the understanding of emotion and cognition and its clinical relevance
    Silvia Bernardi and C. Daniel Salzman
    
    PNAS December 26, 2019 116 (52) 26305-26312; first published December 23, 2019. https://doi.org/10.1073/pnas.1902293116
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    Multiple neuronal circuits for variable object–action choices based on short- and long-term memories
    Okihide Hikosaka, Masaharu Yasuda, Kae Nakamura, Masaki Isoda, Hyoung F. Kim, Yasuo Terao, Hidetoshi Amita, and Kazutaka Maeda
    
    PNAS December 26, 2019 116 (52) 26313-26320; first published December 23, 2019. https://doi.org/10.1073/pnas.1902283116
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    The mind–body problem: Circuits that link the cerebral cortex to the adrenal medulla
    Richard P. Dum, David J. Levinthal, and Peter L. Strick
    
    PNAS December 26, 2019 116 (52) 26321-26328; first published December 23, 2019. https://doi.org/10.1073/pnas.1902297116

Brief Report

Open Access
Reactivation of critical period plasticity in adult auditory cortex through chemogenetic silencing of parvalbumin-positive interneurons
J. Miguel Cisneros-Franco and Étienne de Villers-Sidani

PNAS December 26, 2019 116 (52) 26329-26331; first published December 16, 2019. https://doi.org/10.1073/pnas.1913227117

Physical Sciences

Applied Mathematics
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  A formula for the value of a stochastic game
  Luc Attia and Miquel Oliu-Barton
  
  PNAS December 26, 2019 116 (52) 26435-26443; first published December 16, 2019. https://doi.org/10.1073/pnas.1908643116
Applied Physical Sciences
- Open Access
  Sono-optogenetics facilitated by a circulation-delivered rechargeable light source for minimally invasive optogenetics
  Xiang Wu, Xingjun Zhu, Paul Chong, Junlang Liu, Louis N. Andre, Kyrstyn S. Ong, Kenneth Brinson Jr, Ali I. Mahdi, Jiachen Li, Lief E. Fenno, Huiliang Wang, and Guosong Hong
  
  PNAS December 26, 2019 116 (52) 26332-26342; first published December 6, 2019. https://doi.org/10.1073/pnas.1914387116
- Open Access
  Autonomous bioluminescence imaging of single mammalian cells with the bacterial bioluminescence system
  From the Cover
  
  Carola Gregor, Jasmin K. Pape, Klaus C. Gwosch, Tanja Gilat, Steffen J. Sahl, and Stefan W. Hell
  
  PNAS December 26, 2019 116 (52) 26491-26496; first published December 2, 2019. https://doi.org/10.1073/pnas.1913616116
Biophysics and Computational Biology
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  Anticipating critical transitions in epithelial–hybrid-mesenchymal cell-fate determination
  Sukanta Sarkar, Sudipta Kumar Sinha, Herbert Levine, Mohit Kumar Jolly, and Partha Sharathi Dutta
  
  PNAS December 26, 2019 116 (52) 26343-26352; first published December 16, 2019. https://doi.org/10.1073/pnas.1913773116
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  Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1
  Petros Giastas, Anastasia Mpakali, Athanasios Papakyriakou, Aggelos Lelis, Paraskevi Kokkala, Margarete Neu, Paul Rowland, John Liddle, Dimitris Georgiadis, and Efstratios Stratikos
  
  PNAS December 26, 2019 116 (52) 26709-26716; first published December 16, 2019. https://doi.org/10.1073/pnas.1912070116
- Open Access
  Precise timing is ubiquitous, consistent, and coordinated across a comprehensive, spike-resolved flight motor program
  Joy Putney, Rachel Conn, and Simon Sponberg
  
  PNAS December 26, 2019 116 (52) 26951-26960; first published December 16, 2019. https://doi.org/10.1073/pnas.1907513116
Chemistry
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  Steering CO₂ electroreduction toward ethanol production by a surface-bound Ru polypyridyl carbene catalyst on N-doped porous carbon
  Yanming Liu, Xinfei Fan, Animesh Nayak, Ying Wang, Bing Shan, Xie Quan, and Thomas J. Meyer
  
  PNAS December 26, 2019 116 (52) 26353-26358; first published December 10, 2019. https://doi.org/10.1073/pnas.1907740116
- Open Access
  Nanoscale spectroscopic origins of photoinduced tip–sample force in the midinfrared
  Junghoon Jahng, Eric O. Potma, and Eun Seong Lee
  
  PNAS December 26, 2019 116 (52) 26359-26366; first published December 11, 2019. https://doi.org/10.1073/pnas.1913729116
Computer Sciences
- Open Access
  Individual structural features constrain the mouse functional connectome
  Francesca Melozzi, Eyal Bergmann, Julie A. Harris, Itamar Kahn, Viktor Jirsa, and Christophe Bernard
  
  PNAS December 26, 2019 116 (52) 26961-26969; first published December 11, 2019. https://doi.org/10.1073/pnas.1906694116
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  Deep learning for inferring gene relationships from single-cell expression data
  Ye Yuan and Ziv Bar-Joseph
  
  PNAS December 26, 2019 116 (52) 27151-27158; first published December 10, 2019. https://doi.org/10.1073/pnas.1911536116
Earth, Atmospheric, and Planetary Sciences
- Open Access
  Triple junction kinematics accounts for the 2016 M_w 7.8 Kaikoura earthquake rupture complexity
  Xuhua Shi, Paul Tapponnier, Teng Wang, Shengji Wei, Yu Wang, Xin Wang, and Liqing Jiao
  
  PNAS December 26, 2019 116 (52) 26367-26375; first published December 10, 2019. https://doi.org/10.1073/pnas.1916770116
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  Satellite observations reveal extreme methane leakage from a natural gas well blowout
  Sudhanshu Pandey, Ritesh Gautam, Sander Houweling, Hugo Denier van der Gon, Pankaj Sadavarte, Tobias Borsdorff, Otto Hasekamp, Jochen Landgraf, Paul Tol, Tim van Kempen, Ruud Hoogeveen, Richard van Hees, Steven P. Hamburg, Joannes D. Maasakkers, and Ilse Aben
  
  PNAS December 26, 2019 116 (52) 26376-26381; first published December 16, 2019. https://doi.org/10.1073/pnas.1908712116
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  Disappearance of the last tropical glaciers in the Western Pacific Warm Pool (Papua, Indonesia) appears imminent
  Donaldi S. Permana, Lonnie G. Thompson, Ellen Mosley-Thompson, Mary E. Davis, Ping-Nan Lin, Julien P. Nicolas, John F. Bolzan, Broxton W. Bird, Vladimir N. Mikhalenko, Paolo Gabrielli, Victor Zagorodnov, Keith R. Mountain, Ulrich Schotterer, Wido Hanggoro, Muhammad N. Habibie, Yohanes Kaize, Dodo Gunawan, Gesang Setyadi, Raden D. Susanto, Alfonso Fernández, and Bryan G. Mark
  
  PNAS December 26, 2019 116 (52) 26382-26388; first published December 9, 2019. https://doi.org/10.1073/pnas.1822037116
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  Anisotropic diffusion creep in postperovskite provides a new model for deformation at the core−mantle boundary
  David P. Dobson, Alexander Lindsay-Scott, Simon A. Hunt, Edward Bailey, Ian G. Wood, John P. Brodholt, Lidunka Vocadlo, and John Wheeler
  
  PNAS December 26, 2019 116 (52) 26389-26393; first published December 11, 2019. https://doi.org/10.1073/pnas.1914826116
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  Microbial chemolithotrophy mediates oxidative weathering of granitic bedrock
  Stephanie A. Napieralski, Heather L. Buss, Susan L. Brantley, Seungyeol Lee, Huifang Xu, and Eric E. Roden
  
  PNAS December 26, 2019 116 (52) 26394-26401; first published December 16, 2019. https://doi.org/10.1073/pnas.1909970117
Engineering
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  Temperature-independent thermal radiation
  Alireza Shahsafi, Patrick Roney, You Zhou, Zhen Zhang, Yuzhe Xiao, Chenghao Wan, Raymond Wambold, Jad Salman, Zhaoning Yu, Jiarui Li, Jerzy T. Sadowski, Riccardo Comin, Shriram Ramanathan, and Mikhail A. Kats
  
  PNAS December 26, 2019 116 (52) 26402-26406; first published December 17, 2019. https://doi.org/10.1073/pnas.1911244116
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  Programmable active kirigami metasheets with more freedom of actuation
  Yichao Tang, Yanbin Li, Yaoye Hong, Shu Yang, and Jie Yin
  
  PNAS December 26, 2019 116 (52) 26407-26413; first published December 16, 2019. https://doi.org/10.1073/pnas.1906435116
- Open Access
  Deep learning predicts path-dependent plasticity
  M. Mozaffar, R. Bostanabad, W. Chen, K. Ehmann, J. Cao, and M. A. Bessa
  
  PNAS December 26, 2019 116 (52) 26414-26420; first published December 16, 2019. https://doi.org/10.1073/pnas.1911815116
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  Performance-advantaged ether diesel bioblendstock production by a priori design
  Nabila A. Huq, Xiangchen Huo, Glenn R. Hafenstine, Stephen M. Tifft, Jim Stunkel, Earl D. Christensen, Gina M. Fioroni, Lisa Fouts, Robert L. McCormick, Patrick A. Cherry, Charles S. McEnally, Lisa D. Pfefferle, Matthew R. Wiatrowski, P. Thathiana Benavides, Mary J. Biddy, Raynella M. Connatser, Michael D. Kass, Teresa L. Alleman, Peter C. St. John, Seonah Kim, and Derek R. Vardon
  
  PNAS December 26, 2019 116 (52) 26421-26430; first published December 16, 2019. https://doi.org/10.1073/pnas.1911107116
Physics
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  Universal Fermi-surface anisotropy renormalization for interacting Dirac fermions with long-range interactions
  Jia Ning Leaw, Ho-Kin Tang, Maxim Trushin, Fakher F. Assaad, and Shaffique Adam
  
  PNAS December 26, 2019 116 (52) 26431-26434; first published December 9, 2019. https://doi.org/10.1073/pnas.1913096116
Sustainability Science
- Open Access
  Provincial and sector-level material footprints in China
  Meng Jiang, Paul Behrens, Tao Wang, Zhipeng Tang, Yadong Yu, Dingjiang Chen, Lin Liu, Zijian Ren, Wenji Zhou, Shengjun Zhu, Canfei He, Arnold Tukker, and Bing Zhu
  
  PNAS December 26, 2019 116 (52) 26484-26490; first published December 16, 2019. https://doi.org/10.1073/pnas.1903028116

Biological Sciences

Biochemistry
- Open Access
  Autonomous bioluminescence imaging of single mammalian cells with the bacterial bioluminescence system
  From the Cover
  
  Carola Gregor, Jasmin K. Pape, Klaus C. Gwosch, Tanja Gilat, Steffen J. Sahl, and Stefan W. Hell
  
  PNAS December 26, 2019 116 (52) 26491-26496; first published December 2, 2019. https://doi.org/10.1073/pnas.1913616116
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  Molybdate pumping into the molybdenum storage protein via an ATP-powered piercing mechanism
  Steffen Brünle, Martin L. Eisinger, Juliane Poppe, Deryck J. Mills, Julian D. Langer, Janet Vonck, and Ulrich Ermler
  
  PNAS December 26, 2019 116 (52) 26497-26504; first published December 6, 2019. https://doi.org/10.1073/pnas.1913031116
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  Combining conservation and species-specific differences to determine how human telomerase binds telomeres
  Valerie M. Tesmer, Eric M. Smith, Oana Danciu, Shilpa Padmanaban, and Jayakrishnan Nandakumar
  
  PNAS December 26, 2019 116 (52) 26505-26515; first published December 10, 2019. https://doi.org/10.1073/pnas.1911912116
- Open Access
  The antimicrobial peptide ZY4 combats multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii infection
  James Mwangi, Yizhu Yin, Gan Wang, Min Yang, Ya Li, Zhiye Zhang, and Ren Lai
  
  PNAS December 26, 2019 116 (52) 26516-26522; first published December 16, 2019. https://doi.org/10.1073/pnas.1909585117
- Open Access
  Approaching infinite affinity through engineering of peptide–protein interaction
  Anthony H. Keeble, Paula Turkki, Samuel Stokes, Irsyad N. A. Khairil Anuar, Rolle Rahikainen, Vesa P. Hytönen, and Mark Howarth
  
  PNAS December 26, 2019 116 (52) 26523-26533; first published December 10, 2019. https://doi.org/10.1073/pnas.1909653116
Biophysics and Computational Biology
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  Anticipating critical transitions in epithelial–hybrid-mesenchymal cell-fate determination
  Sukanta Sarkar, Sudipta Kumar Sinha, Herbert Levine, Mohit Kumar Jolly, and Partha Sharathi Dutta
  
  PNAS December 26, 2019 116 (52) 26343-26352; first published December 16, 2019. https://doi.org/10.1073/pnas.1913773116
- Open Access
  Supercoiling DNA optically
  Graeme A. King, Federica Burla, Erwin J. G. Peterman, and Gijs J. L. Wuite
  
  PNAS December 26, 2019 116 (52) 26534-26539; first published December 5, 2019. https://doi.org/10.1073/pnas.1908826116
- Open Access
  Defining the remarkable structural malleability of a bacterial surface protein Rib domain implicated in infection
  Fiona Whelan, Aleix Lafita, Samuel C. Griffiths, Rachael E. M. Cooper, Jean L. Whittingham, Johan P. Turkenburg, Iain W. Manfield, Alexander N. St. John, Emanuele Paci, Alex Bateman, and Jennifer R. Potts
  
  PNAS December 26, 2019 116 (52) 26540-26548; first published December 9, 2019. https://doi.org/10.1073/pnas.1911776116
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  Valproic acid interactions with the NavMs voltage-gated sodium channel
  Geancarlo Zanatta, Altin Sula, Andrew J. Miles, Leo C. T. Ng, Rubben Torella, David C. Pryde, Paul G. DeCaen, and B. A. Wallace
  
  PNAS December 26, 2019 116 (52) 26549-26554; first published December 10, 2019. https://doi.org/10.1073/pnas.1909696116
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  Increased stiffness and flow resistance of the inner wall of Schlemm’s canal in glaucomatous human eyes
  Amir Vahabikashi, Ariel Gelman, Biqin Dong, Lihua Gong, Elliott D. K. Cha, Margit Schimmel, Ernst R. Tamm, Kristin Perkumas, W. Daniel Stamer, Cheng Sun, Hao F. Zhang, Haiyan Gong, and Mark Johnson
  
  PNAS December 26, 2019 116 (52) 26555-26563; first published December 5, 2019. https://doi.org/10.1073/pnas.1911837116
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  Microtubule binding kinetics of membrane-bound kinesin-1 predicts high motor copy numbers on intracellular cargo
  Rui Jiang, Steven Vandal, SooHyun Park, Sheereen Majd, Erkan Tüzel, and William O. Hancock
  
  PNAS December 26, 2019 116 (52) 26564-26570; first published December 10, 2019. https://doi.org/10.1073/pnas.1916204116
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  On the possible origin of protein homochirality, structure, and biochemical function
  Jeffrey Skolnick, Hongyi Zhou, and Mu Gao
  
  PNAS December 26, 2019 116 (52) 26571-26579; first published December 10, 2019. https://doi.org/10.1073/pnas.1908241116
Cell Biology
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  Pancreatic cancer organoids recapitulate disease and allow personalized drug screening
  Else Driehuis, Arne van Hoeck, Kat Moore, Sigrid Kolders, Hayley E. Francies, M. Can Gulersonmez, Edwin C. A. Stigter, Boudewijn Burgering, Veerle Geurts, Ana Gracanin, Gergana Bounova, Folkert H. Morsink, Robert Vries, Sylvia Boj, Johan van Es, G. Johan A. Offerhaus, Onno Kranenburg, Mathew J. Garnett, Lodewyk Wessels, Edwin Cuppen, Lodewijk A. A. Brosens, and Hans Clevers
  
  PNAS December 26, 2019 116 (52) 26580-26590; first published December 9, 2019. https://doi.org/10.1073/pnas.1911273116
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  The role of translationally controlled tumor protein in proliferation of Drosophila intestinal stem cells
  Young V. Kwon, Bingqing Zhao, Chiwei Xu, Jiae Lee, Chiao-Lin Chen, Arunachalam Vinayagam, Bruce A. Edgar, and Norbert Perrimon
  
  PNAS December 26, 2019 116 (52) 26591-26598; first published December 16, 2019. https://doi.org/10.1073/pnas.1910850116
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  Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion
  Johan H. van Es, Kay Wiebrands, Carmen López-Iglesias, Marc van de Wetering, Laura Zeinstra, Maaike van den Born, Jeroen Korving, Nobuo Sasaki, Peter J. Peters, Alexander van Oudenaarden, and Hans Clevers
  
  PNAS December 26, 2019 116 (52) 26599-26605; first published December 16, 2019. https://doi.org/10.1073/pnas.1801888117
- Open Access
  Loss of p57^KIP2 expression confers resistance to contact inhibition in human androgenetic trophoblast stem cells
  Sota Takahashi, Hiroaki Okae, Norio Kobayashi, Akane Kitamura, Kanako Kumada, Nobuo Yaegashi, and Takahiro Arima
  
  PNAS December 26, 2019 116 (52) 26606-26613; first published December 2, 2019. https://doi.org/10.1073/pnas.1916019116
- Open Access
  Reactivation of Epstein–Barr virus by a dual-responsive fluorescent EBNA1-targeting agent with Zn²⁺-chelating function
  Lijun Jiang, Hong Lok Lung, Tao Huang, Rongfeng Lan, Shuai Zha, Lai Sheung Chan, Waygen Thor, Tik-Hung Tsoi, Ho-Fai Chau, Cecilia Boreström, Steven L. Cobb, Sai Wah Tsao, Zhao-Xiang Bian, Ga-Lai Law, Wing-Tak Wong, William Chi-Shing Tai, Wai Yin Chau, Yujun Du, Lucas Hao Xi Tang, Alan Kwok Shing Chiang, Jaap M. Middeldorp, Kwok-Wai Lo, Nai Ki Mak, Nicholas J. Long, and Ka-Leung Wong
  
  PNAS December 26, 2019 116 (52) 26614-26624; first published December 10, 2019. https://doi.org/10.1073/pnas.1915372116
- You have access
  SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis
  Kai Su Greene, Michael J. Lukey, Xueying Wang, Bryant Blank, Joseph E. Druso, Miao-chong J. Lin, Clint A. Stalnecker, Chengliang Zhang, Yashira Negrón Abril, Jon W. Erickson, Kristin F. Wilson, Hening Lin, Robert S. Weiss, and Richard A. Cerione
  
  PNAS December 26, 2019 116 (52) 26625-26632; first published December 16, 2019. https://doi.org/10.1073/pnas.1911954116
- Open Access
  Peripheral (not central) corneal epithelia contribute to the closure of an annular debridement injury
  Mijeong Park, Alexander Richardson, Elvis Pandzic, Erwin P. Lobo, J. Guy Lyons, and Nick Di Girolamo
  
  PNAS December 26, 2019 116 (52) 26633-26643; first published December 16, 2019. https://doi.org/10.1073/pnas.1912260116
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  A cis-element within the ARF locus mediates repression of p16^INK4A expression via long-range chromatin interactions
  Yang Zhang, Judith Hyle, Shaela Wright, Ying Shao, Xujie Zhao, Hui Zhang, and Chunliang Li
  
  PNAS December 26, 2019 116 (52) 26644-26652; first published December 9, 2019. https://doi.org/10.1073/pnas.1909720116
Ecology
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  Toward a metabolic theory of life history
  Joseph Robert Burger, Chen Hou, and James H. Brown
  
  PNAS December 26, 2019 116 (52) 26653-26661; first published December 10, 2019. https://doi.org/10.1073/pnas.1907702116
- You have access
  Modeling active sensing reveals echo detection even in large groups of bats
  Thejasvi Beleyur and Holger R. Goerlitz
  
  PNAS December 26, 2019 116 (52) 26662-26668; first published December 10, 2019. https://doi.org/10.1073/pnas.1821722116
- Open Access
  Postreproductive killer whale grandmothers improve the survival of their grandoffspring
  Stuart Nattrass, Darren P. Croft, Samuel Ellis, Michael A. Cant, Michael N. Weiss, Brianna M. Wright, Eva Stredulinsky, Thomas Doniol-Valcroze, John K. B. Ford, Kenneth C. Balcomb, and Daniel W. Franks
  
  PNAS December 26, 2019 116 (52) 26669-26673; first published December 9, 2019. https://doi.org/10.1073/pnas.1903844116
- Open Access
  Human activities have opposing effects on distributions of narrow-ranged and widespread plant species in China
  Wu-Bing Xu, Jens-Christian Svenning, Guo-Ke Chen, Ming-Gang Zhang, Ji-Hong Huang, Bin Chen, Alejandro Ordonez, and Ke-Ping Ma
  
  PNAS December 26, 2019 116 (52) 26674-26681; first published December 16, 2019. https://doi.org/10.1073/pnas.1911851116
- Open Access
  Resurgence of an apex marine predator and the decline in prey body size
  Jan Ohlberger, Daniel E. Schindler, Eric J. Ward, Timothy E. Walsworth, and Timothy E. Essington
  
  PNAS December 26, 2019 116 (52) 26682-26689; first published December 16, 2019. https://doi.org/10.1073/pnas.1910930116
Environmental Sciences
- Open Access
  Climate variability reduces employment in New England fisheries
  Kimberly L. Oremus
  
  PNAS December 26, 2019 116 (52) 26444-26449; first published December 9, 2019. https://doi.org/10.1073/pnas.1820154116
Evolution
- You have access
  Receding ice drove parallel expansions in Southern Ocean penguins
  Theresa L. Cole, Ludovic Dutoit, Nicolas Dussex, Tom Hart, Alana Alexander, Jane L. Younger, Gemma V. Clucas, María José Frugone, Yves Cherel, Richard Cuthbert, Ursula Ellenberg, Steven R. Fiddaman, Johanna Hiscock, David Houston, Pierre Jouventin, Thomas Mattern, Gary Miller, Colin Miskelly, Paul Nolan, Michael J. Polito, Petra Quillfeldt, Peter G. Ryan, Adrian Smith, Alan J. D. Tennyson, David Thompson, Barbara Wienecke, Juliana A. Vianna, and Jonathan M. Waters
  
  PNAS December 26, 2019 116 (52) 26690-26696; first published December 16, 2019. https://doi.org/10.1073/pnas.1904048116
Genetics
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  Gene- and tissue-level interactions in normal gastrointestinal development and Hirschsprung disease
  Sumantra Chatterjee, Priyanka Nandakumar, Dallas R. Auer, Stacey B. Gabriel, and Aravinda Chakravarti
  
  PNAS December 26, 2019 116 (52) 26697-26708; first published December 9, 2019. https://doi.org/10.1073/pnas.1908756116
Immunology and Inflammation
- You have access
  Symbionts exploit complex signaling to educate the immune system
  Inaugural Article
  
  Deniz Erturk-Hasdemir, Sungwhan F. Oh, Nihal A. Okan, Giuseppe Stefanetti, Francesca S. Gazzaniga, Peter H. Seeberger, Scott E. Plevy, and Dennis L. Kasper
  
  PNAS December 26, 2019 116 (52) 26157-26166; first published December 6, 2019. https://doi.org/10.1073/pnas.1915978116
  
  See companion article:
  Profile of Dennis L. Kasper
  - Dec 02, 2019
- You have access
  Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1
  Petros Giastas, Anastasia Mpakali, Athanasios Papakyriakou, Aggelos Lelis, Paraskevi Kokkala, Margarete Neu, Paul Rowland, John Liddle, Dimitris Georgiadis, and Efstratios Stratikos
  
  PNAS December 26, 2019 116 (52) 26709-26716; first published December 16, 2019. https://doi.org/10.1073/pnas.1912070116
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  Neutralization of IL-1α ameliorates Crohn’s disease-like ileitis by functional alterations of the gut microbiome
  Paola Menghini, Daniele Corridoni, Ludovica F. Buttó, Abdullah Osme, Sushma Shivaswamy, Minh Lam, Giorgos Bamias, Theresa T. Pizarro, Alexander Rodriguez-Palacios, Charles A. Dinarello, and Fabio Cominelli
  
  PNAS December 26, 2019 116 (52) 26717-26726; first published December 16, 2019. https://doi.org/10.1073/pnas.1915043116
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  T cell receptor specificity drives accumulation of a reparative population of regulatory T cells within acutely injured skeletal muscle
  Jun Cho, Wilson Kuswanto, Christophe Benoist, and Diane Mathis
  
  PNAS December 26, 2019 116 (52) 26727-26733; first published December 10, 2019. https://doi.org/10.1073/pnas.1914848116
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  Comprehensive analysis of a mouse model of spontaneous uveoretinitis using single-cell RNA sequencing
  Jacob S. Heng, Sean F. Hackett, Genevieve L. Stein-O’Brien, Briana L. Winer, John Williams, Loyal A. Goff, and Jeremy Nathans
  
  PNAS December 26, 2019 116 (52) 26734-26744; first published December 16, 2019. https://doi.org/10.1073/pnas.1915571116
- Open Access
  Affinity maturation in a human humoral response to influenza hemagglutinin
  Kevin R. McCarthy, Donald D. Raymond, Khoi T. Do, Aaron G. Schmidt, and Stephen C. Harrison
  
  PNAS December 26, 2019 116 (52) 26745-26751; first published December 16, 2019. https://doi.org/10.1073/pnas.1915620116
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  Intermittent rolling is a defect of the extravasation cascade caused by Myosin1e-deficiency in neutrophils
  Eduardo Vadillo, Sandra Chánez-Paredes, Hilda Vargas-Robles, Idaira María Guerrero-Fonseca, Ramón Castellanos-Martínez, Alexander García-Ponce, Porfirio Nava, Daniel Alberto Girón-Pérez, Leopoldo Santos-Argumedo, and Michael Schnoor
  
  PNAS December 26, 2019 116 (52) 26752-26758; first published December 6, 2019. https://doi.org/10.1073/pnas.1902502116
- Open Access
  Evolutionary transition from degenerate to nonredundant cytokine signaling networks supporting intrathymic T cell development
  Divine-Fondzenyuy Lawir, Isabell Hess, Katarzyna Sikora, Norimasa Iwanami, Iliana Siamishi, Michael Schorpp, and Thomas Boehm
  
  PNAS December 26, 2019 116 (52) 26759-26767; first published December 10, 2019. https://doi.org/10.1073/pnas.1915223116
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  Ly49R activation receptor drives self-MHC–educated NK cell immunity against cytomegalovirus infection
  Awndre Gamache, John M. Cronk, William T. Nash, Patryk Puchalski, Alyssa Gillespie, Hairong Wei, Laurie Gray, Marie-Louise Hammarskjold, Wenhao Xu, and Michael G. Brown
  
  PNAS December 26, 2019 116 (52) 26768-26778; first published December 16, 2019. https://doi.org/10.1073/pnas.1913064117
- Open Access
  Parent-of-origin differences in DNA methylation of X chromosome genes in T lymphocytes
  From the Cover
  
  Lisa C. Golden, Yuichiro Itoh, Noriko Itoh, Sonia Iyengar, Patrick Coit, Youstina Salama, Arthur P. Arnold, Amr H. Sawalha, and Rhonda R. Voskuhl
  
  PNAS December 26, 2019 116 (52) 26779-26787; first published December 10, 2019. https://doi.org/10.1073/pnas.1910072116
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  Activation-induced cell death of self-reactive regulatory T cells drives autoimmunity
  Ester Badami, Olivier N. F. Cexus, and Sonia Quaratino
  
  PNAS December 26, 2019 116 (52) 26788-26797; first published December 9, 2019. https://doi.org/10.1073/pnas.1910281116
Medical Sciences
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  Characterization of splice-altering mutations in inherited predisposition to cancer
  Silvia Casadei, Suleyman Gulsuner, Brian H. Shirts, Jessica B. Mandell, Hannah M. Kortbawi, Barbara S. Norquist, Elizabeth M. Swisher, Ming K. Lee, Yael Goldberg, Robert O’Connor, Zheng Tan, Colin C. Pritchard, Mary-Claire King, and Tom Walsh
  
  PNAS December 26, 2019 116 (52) 26798-26807; first published December 16, 2019. https://doi.org/10.1073/pnas.1915608116
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  Oxytocin regulates body composition
  Li Sun, Daria Lizneva, Yaoting Ji, Graziana Colaianni, Elina Hadelia, Anisa Gumerova, Kseniia Ievleva, Tan-Chun Kuo, Funda Korkmaz, Vitaly Ryu, Alina Rahimova, Sakshi Gera, Charit Taneja, Ayesha Khan, Naseer Ahmad, Roberto Tamma, Zhuan Bian, Alberta Zallone, Se-Min Kim, Maria I. New, Jameel Iqbal, Tony Yuen, and Mone Zaidi
  
  PNAS December 26, 2019 116 (52) 26808-26815; first published December 16, 2019. https://doi.org/10.1073/pnas.1913611116
- Open Access
  IgGs from patients with amyotrophic lateral sclerosis and diabetes target Ca_Vα₂δ1 subunits impairing islet cell function and survival
  Yue Shi, Kyoung Sun Park, Seung Hyun Kim, Jia Yu, Kaixuan Zhao, Lina Yu, Ki Wook Oh, Kayoung Lee, Jaeyoon Kim, Kanchan Chaggar, Yuxin Li, Annette C. Dolphin, William A. Catterall, Sung Ho Ryu, Shao-Nian Yang, and Per-Olof Berggren
  
  PNAS December 26, 2019 116 (52) 26816-26822; first published December 11, 2019. https://doi.org/10.1073/pnas.1911956116
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  FOXA1 upregulation promotes enhancer and transcriptional reprogramming in endocrine-resistant breast cancer
  Xiaoyong Fu, Resel Pereira, Carmine De Angelis, Jamunarani Veeraraghavan, Sarmistha Nanda, Lanfang Qin, Maria L. Cataldo, Vidyalakshmi Sethunath, Sepideh Mehravaran, Carolina Gutierrez, Gary C. Chamness, Qin Feng, Bert W. O’Malley, Pier Selenica, Britta Weigelt, Jorge S. Reis-Filho, Ofir Cohen, Nikhil Wagle, Agostina Nardone, Rinath Jeselsohn, Myles Brown, Mothaffar F. Rimawi, C. Kent Osborne, and Rachel Schiff
  
  PNAS December 26, 2019 116 (52) 26823-26834; first published December 11, 2019. https://doi.org/10.1073/pnas.1911584116
- Open Access
  Epithelial to mesenchymal plasticity and differential response to therapies in pancreatic ductal adenocarcinoma
  Rebecca L. Porter, Neelima K. C. Magnus, Vishal Thapar, Robert Morris, Annamaria Szabolcs, Azfar Neyaz, Anupriya S. Kulkarni, Eric Tai, Abhijit Chougule, Alessandra Hillis, Gabriel Golczer, Hongshan Guo, Teppei Yamada, Tomohiro Kurokawa, Chittampalli Yashaswini, Matteo Ligorio, Kevin D. Vo, Linda Nieman, Andrew S. Liss, Vikram Deshpande, Michael S. Lawrence, Shyamala Maheswaran, Carlos Fernandez-Del Castillo, Theodore S. Hong, David P. Ryan, Peter J. O’Dwyer, Jeffrey A. Drebin, Cristina R. Ferrone, Daniel A. Haber, and David T. Ting
  
  PNAS December 26, 2019 116 (52) 26835-26845; first published December 16, 2019. https://doi.org/10.1073/pnas.1914915116
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  CRISPR/Cas9-based targeted genome editing for correction of recessive dystrophic epidermolysis bullosa using iPS cells
  From the Cover
  
  Joanna Jacków, Zongyou Guo, Corey Hansen, Hasan E. Abaci, Yanne S. Doucet, Jung U Shin, Ryota Hayashi, Dominick DeLorenzo, Yudai Kabata, Satoru Shinkuma, Julio C. Salas-Alanis, and Angela M. Christiano
  
  PNAS December 26, 2019 116 (52) 26846-26852; first published December 9, 2019. https://doi.org/10.1073/pnas.1907081116
  
  See companion article:
  Toward treatment and cure of epidermolysis bullosa
  - Dec 11, 2019
- You have access
  The emergence of classical BSE from atypical/Nor98 scrapie
  Alvina Huor, Juan Carlos Espinosa, Enric Vidal, Hervé Cassard, Jean-Yves Douet, Séverine Lugan, Naima Aron, Alba Marín-Moreno, Patricia Lorenzo, Patricia Aguilar-Calvo, Juan Badiola, Rosa Bolea, Martí Pumarola, Sylvie L. Benestad, Leonore Orge, Alana M. Thackray, Raymond Bujdoso, Juan-Maria Torres, and Olivier Andreoletti
  
  PNAS December 26, 2019 116 (52) 26853-26862; first published December 16, 2019. https://doi.org/10.1073/pnas.1915737116
- Open Access
  Extensive subclonal mutational diversity in human colorectal cancer and its significance
  Lawrence A. Loeb, Brendan F. Kohrn, Kaitlyn J. Loubet-Senear, Yasmin J. Dunn, Eun Hyun Ahn, Jacintha N. O’Sullivan, Jesse J. Salk, Mary P. Bronner, and Robert A. Beckman
  
  PNAS December 26, 2019 116 (52) 26863-26872; first published December 5, 2019. https://doi.org/10.1073/pnas.1910301116
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  A tumorigenic index for quantitative analysis of liver cancer initiation and progression
  Gaowei Wang, Xiaolin Luo, Yan Liang, Kota Kaneko, Hairi Li, Xiang-Dong Fu, and Gen-Sheng Feng
  
  PNAS December 26, 2019 116 (52) 26873-26880; first published December 16, 2019. https://doi.org/10.1073/pnas.1911193116
Microbiology
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  Evolution of resistance in vitro reveals mechanisms of artemisinin activity in Toxoplasma gondii
  Alex Rosenberg, Madeline R. Luth, Elizabeth A. Winzeler, Michael Behnke, and L. David Sibley
  
  PNAS December 26, 2019 116 (52) 26881-26891; first published December 5, 2019. https://doi.org/10.1073/pnas.1914732116
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  Extracellular electron transfer powers flavinylated extracellular reductases in Gram-positive bacteria
  Samuel H. Light, Raphaël Méheust, Jessica L. Ferrell, Jooyoung Cho, David Deng, Marco Agostoni, Anthony T. Iavarone, Jillian F. Banfield, Sarah E. F. D’Orazio, and Daniel A. Portnoy
  
  PNAS December 26, 2019 116 (52) 26892-26899; first published December 9, 2019. https://doi.org/10.1073/pnas.1915678116
- Open Access
  Cross-genotype protection of live-attenuated vaccine candidate for severe fever with thrombocytopenia syndrome virus in a ferret model
  Kwang-Min Yu, Su-Jin Park, Min-Ah Yu, Young-Il Kim, Younho Choi, Jae U. Jung, Benjamin Brennan, and Young Ki Choi
  
  PNAS December 26, 2019 116 (52) 26900-26908; first published December 9, 2019. https://doi.org/10.1073/pnas.1914704116
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  Antitumor astins originate from the fungal endophyte Cyanodermella asteris living within the medicinal plant Aster tataricus
  Thomas Schafhauser, Linda Jahn, Norbert Kirchner, Andreas Kulik, Liane Flor, Alexander Lang, Thibault Caradec, David P. Fewer, Kaarina Sivonen, Willem J. H. van Berkel, Philippe Jacques, Tilmann Weber, Harald Gross, Karl-Heinz van Pée, Wolfgang Wohlleben, and Jutta Ludwig-Müller
  
  PNAS December 26, 2019 116 (52) 26909-26917; first published December 6, 2019. https://doi.org/10.1073/pnas.1910527116
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  A population shift between two heritable cell types of the pathogen Candida albicans is based both on switching and selective proliferation
  Chiraj K. Dalal, Ignacio A. Zuleta, Matthew B. Lohse, Rebecca E. Zordan, Hana El-Samad, and Alexander D. Johnson
  
  PNAS December 26, 2019 116 (52) 26918-26924; first published December 10, 2019. https://doi.org/10.1073/pnas.1908986116
- Open Access
  Antimicrobial sensing coupled with cell membrane remodeling mediates antibiotic resistance and virulence in Enterococcus faecalis
  Ayesha Khan, Milya Davlieva, Diana Panesso, Sandra Rincon, William R. Miller, Lorena Diaz, Jinnethe Reyes, Melissa R. Cruz, Orville Pemberton, April H. Nguyen, Sara D. Siegel, Paul J. Planet, Apurva Narechania, Mauricio Latorre, Rafael Rios, Kavindra V. Singh, Hung Ton-That, Danielle A. Garsin, Truc T. Tran, Yousif Shamoo, and Cesar A. Arias
  
  PNAS December 26, 2019 116 (52) 26925-26932; first published December 9, 2019. https://doi.org/10.1073/pnas.1916037116
- Open Access
  Viral neutralization by antibody-imposed physical disruption
  Qingbing Zheng, Jie Jiang, Maozhou He, Zizheng Zheng, Hai Yu, Tingting Li, Wenhui Xue, Zimin Tang, Dong Ying, Zekai Li, Shuo Song, Xinlin Liu, Kaihang Wang, Zhiqing Zhang, Daning Wang, Yingbin Wang, Xiaodong Yan, Qinjian Zhao, Jun Zhang, Ying Gu, Shaowei Li, and Ningshao Xia
  
  PNAS December 26, 2019 116 (52) 26933-26940; first published December 9, 2019. https://doi.org/10.1073/pnas.1916028116
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  Inhibition of ULK1 and Beclin1 by an α-herpesvirus Akt-like Ser/Thr kinase limits autophagy to stimulate virus replication
  Rosa M. Rubio and Ian Mohr
  
  PNAS December 26, 2019 116 (52) 26941-26950; first published December 16, 2019. https://doi.org/10.1073/pnas.1915139116
Neuroscience
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  Cerebral cortical folding, parcellation, and connectivity in humans, nonhuman primates, and mice
  David C. Van Essen, Chad J. Donahue, Timothy S. Coalson, Henry Kennedy, Takuya Hayashi, and Matthew F. Glasser
  
  PNAS December 26, 2019 116 (52) 26173-26180; first published December 23, 2019. https://doi.org/10.1073/pnas.1902299116
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  Translational implications of the anatomical nonequivalence of functionally equivalent cholinergic circuit motifs
  Anita A. Disney and Jason S. Robert
  
  PNAS December 26, 2019 116 (52) 26181-26186; first published December 23, 2019. https://doi.org/10.1073/pnas.1902280116
- You have access
  Attention can be subdivided into neurobiological components corresponding to distinct behavioral effects
  Thomas Zhihao Luo and John H. R. Maunsell
  
  PNAS December 26, 2019 116 (52) 26187-26194; first published December 23, 2019. https://doi.org/10.1073/pnas.1902286116
- You have access
  Primate optogenetics: Progress and prognosis
  Yasmine El-Shamayleh and Gregory D. Horwitz
  
  PNAS December 26, 2019 116 (52) 26195-26203; first published December 23, 2019. https://doi.org/10.1073/pnas.1902284116
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  Nonhuman primate models of hippocampal development and dysfunction
  Jocelyne Bachevalier
  
  PNAS December 26, 2019 116 (52) 26210-26216; first published December 23, 2019. https://doi.org/10.1073/pnas.1902278116
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  Understanding the development of amblyopia using macaque monkey models
  Lynne Kiorpes
  
  PNAS December 26, 2019 116 (52) 26217-26223; first published December 23, 2019. https://doi.org/10.1073/pnas.1902285116
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  Alzheimer’s-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer’s disease
  Amy F. T. Arnsten, Dibyadeep Datta, Shannon Leslie, Sheng-Tao Yang, Min Wang, and Angus C. Nairn
  
  PNAS December 26, 2019 116 (52) 26230-26238; first published December 23, 2019. https://doi.org/10.1073/pnas.1903671116
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  Oligomeric Aβ in the monkey brain impacts synaptic integrity and induces accelerated cortical aging
  Danielle Beckman, Sean Ott, Kristine Donis-Cox, William G. Janssen, Eliza Bliss-Moreau, Peter H. Rudebeck, Mark G. Baxter, and John H. Morrison
  
  PNAS December 26, 2019 116 (52) 26239-26246; first published December 23, 2019. https://doi.org/10.1073/pnas.1902301116
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  Experiments in macaque monkeys provide critical insights into age-associated changes in cognitive and sensory function
  Daniel T. Gray and Carol A. Barnes
  
  PNAS December 26, 2019 116 (52) 26247-26254; first published December 23, 2019. https://doi.org/10.1073/pnas.1902279116
- You have access
  Understanding Parkinson’s disease and deep brain stimulation: Role of monkey models
  Jerrold L. Vitek and Luke A. Johnson
  
  PNAS December 26, 2019 116 (52) 26259-26265; first published December 23, 2019. https://doi.org/10.1073/pnas.1902300116
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  Distributed processing of movement signaling
  Scott D. Kennedy and Andrew B. Schwartz
  
  PNAS December 26, 2019 116 (52) 26266-26273; first published December 23, 2019. https://doi.org/10.1073/pnas.1902296116
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  From thought to action: The brain–machine interface in posterior parietal cortex
  Richard A. Andersen, Tyson Aflalo, and Spencer Kellis
  
  PNAS December 26, 2019 116 (52) 26274-26279; first published December 23, 2019. https://doi.org/10.1073/pnas.1902276116
- You have access
  The primate model for understanding and restoring vision
  Serge Picaud, Deniz Dalkara, Katia Marazova, Olivier Goureau, Botond Roska, and José-Alain Sahel
  
  PNAS December 26, 2019 116 (52) 26280-26287; first published December 23, 2019. https://doi.org/10.1073/pnas.1902292116
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  Why we need nonhuman primates to study the role of ventromedial prefrontal cortex in the regulation of threat- and reward-elicited responses
  Angela C. Roberts and Hannah F. Clarke
  
  PNAS December 26, 2019 116 (52) 26297-26304; first published December 23, 2019. https://doi.org/10.1073/pnas.1902288116
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  The contribution of nonhuman primate research to the understanding of emotion and cognition and its clinical relevance
  Silvia Bernardi and C. Daniel Salzman
  
  PNAS December 26, 2019 116 (52) 26305-26312; first published December 23, 2019. https://doi.org/10.1073/pnas.1902293116
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  Multiple neuronal circuits for variable object–action choices based on short- and long-term memories
  Okihide Hikosaka, Masaharu Yasuda, Kae Nakamura, Masaki Isoda, Hyoung F. Kim, Yasuo Terao, Hidetoshi Amita, and Kazutaka Maeda
  
  PNAS December 26, 2019 116 (52) 26313-26320; first published December 23, 2019. https://doi.org/10.1073/pnas.1902283116
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  The mind–body problem: Circuits that link the cerebral cortex to the adrenal medulla
  Richard P. Dum, David J. Levinthal, and Peter L. Strick
  
  PNAS December 26, 2019 116 (52) 26321-26328; first published December 23, 2019. https://doi.org/10.1073/pnas.1902297116
- Open Access
  Precise timing is ubiquitous, consistent, and coordinated across a comprehensive, spike-resolved flight motor program
  Joy Putney, Rachel Conn, and Simon Sponberg
  
  PNAS December 26, 2019 116 (52) 26951-26960; first published December 16, 2019. https://doi.org/10.1073/pnas.1907513116
- Open Access
  Individual structural features constrain the mouse functional connectome
  Francesca Melozzi, Eyal Bergmann, Julie A. Harris, Itamar Kahn, Viktor Jirsa, and Christophe Bernard
  
  PNAS December 26, 2019 116 (52) 26961-26969; first published December 11, 2019. https://doi.org/10.1073/pnas.1906694116
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  Ventral hippocampus interacts with prelimbic cortex during inhibition of threat response via learned safety in both mice and humans
  Heidi C. Meyer, Paola Odriozola, Emily M. Cohodes, Jeffrey D. Mandell, Anfei Li, Ruirong Yang, Baila S. Hall, Jason T. Haberman, Sadie J. Zacharek, Conor Liston, Francis S. Lee, and Dylan G. Gee
  
  PNAS December 26, 2019 116 (52) 26970-26979; first published December 10, 2019. https://doi.org/10.1073/pnas.1910481116
- Open Access
  Molecular profiling of single neurons of known identity in two ganglia from the crab Cancer borealis
  Adam J. Northcutt, Daniel R. Kick, Adriane G. Otopalik, Benjamin M. Goetz, Rayna M. Harris, Joseph M. Santin, Hans A. Hofmann, Eve Marder, and David J. Schulz
  
  PNAS December 26, 2019 116 (52) 26980-26990; first published December 5, 2019. https://doi.org/10.1073/pnas.1911413116
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  The network architecture of rat intrinsic interbrain (diencephalic) macroconnections
  Larry W. Swanson, Olaf Sporns, and Joel D. Hahn
  
  PNAS December 26, 2019 116 (52) 26991-27000; first published December 5, 2019. https://doi.org/10.1073/pnas.1915446116
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  Sources of off-target expression from recombinase-dependent AAV vectors and mitigation with cross-over insensitive ATG-out vectors
  Kyle B. Fischer, Hannah K. Collins, and Edward M. Callaway
  
  PNAS December 26, 2019 116 (52) 27001-27010; first published December 16, 2019. https://doi.org/10.1073/pnas.1915974116
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  Synaptic control of spinal GRPR⁺ neurons by local and long-range inhibitory inputs
  Ming-Zhe Liu, Xiao-Jun Chen, Tong-Yu Liang, Qing Li, Meng Wang, Xin-Yan Zhang, Yu-Zhuo Li, Qiang Sun, and Yan-Gang Sun
  
  PNAS December 26, 2019 116 (52) 27011-27017; first published December 5, 2019. https://doi.org/10.1073/pnas.1905658116
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  Second-order cues to figure motion enable object detection during prey capture by praying mantises
  Vivek Nityananda, James O’Keeffe, Diana Umeton, Adam Simmons, and Jenny C. A. Read
  
  PNAS December 26, 2019 116 (52) 27018-27027; first published December 9, 2019. https://doi.org/10.1073/pnas.1912310116
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  5-HT_2A receptor activation normalizes stress-induced dysregulation of GABAergic signaling in the ventral tegmental area
  Blake A. Kimmey, Alexey Ostroumov, and John A. Dani
  
  PNAS December 26, 2019 116 (52) 27028-27034; first published December 5, 2019. https://doi.org/10.1073/pnas.1911446116
- Open Access
  Position–theta-phase model of hippocampal place cell activity applied to quantification of running speed modulation of firing rate
  Kathryn McClain, David Tingley, David J. Heeger, and György Buzsáki
  
  PNAS December 26, 2019 116 (52) 27035-27042; first published December 16, 2019. https://doi.org/10.1073/pnas.1912792116
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  Photoreceptor disc membranes are formed through an Arp2/3-dependent lamellipodium-like mechanism
  William J. Spencer, Tylor R. Lewis, Sebastien Phan, Martha A. Cady, Ekaterina O. Serebrovskaya, Nicholas F. Schneider, Keun-Young Kim, Lisa A. Cameron, Nikolai P. Skiba, Mark H. Ellisman, and Vadim Y. Arshavsky
  
  PNAS December 26, 2019 116 (52) 27043-27052; first published December 16, 2019. https://doi.org/10.1073/pnas.1913518117
- Open Access
  A systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropism
  Marcus Davidsson, Gang Wang, Patrick Aldrin-Kirk, Tiago Cardoso, Sara Nolbrant, Morgan Hartnor, Janitha Mudannayake, Malin Parmar, and Tomas Björklund
  
  PNAS December 26, 2019 116 (52) 27053-27062; first published December 9, 2019. https://doi.org/10.1073/pnas.1910061116
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  Perineuronal nets protect long-term memory by limiting activity-dependent inhibition from parvalbumin interneurons
  Wei Shi, Xiangbo Wei, Xiaofei Wang, Shuwen Du, Weixuan Liu, Jian Song, and Yun Wang
  
  PNAS December 26, 2019 116 (52) 27063-27073; first published December 16, 2019. https://doi.org/10.1073/pnas.1902680116
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  Evoked potentials as a biomarker of remyelination
  Moones Heidari, Abigail B. Radcliff, Gillian J. McLellan, James N. Ver Hoeve, Kore Chan, Julie A. Kiland, Nicholas S. Keuler, Benjamin K. August, Dylan Sebo, Aaron S. Field, and Ian D. Duncan
  
  PNAS December 26, 2019 116 (52) 27074-27083; first published December 16, 2019. https://doi.org/10.1073/pnas.1906358116
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  Descending projections from the substantia nigra pars reticulata differentially control seizures
  Evan Wicker, Veronica C. Beck, Colin Kulick-Soper, Catherine V. Kulick-Soper, Safwan K. Hyder, Carolina Campos-Rodriguez, Tahiyana Khan, Prosper N’Gouemo, and Patrick A. Forcelli
  
  PNAS December 26, 2019 116 (52) 27084-27094; first published December 16, 2019. https://doi.org/10.1073/pnas.1908176117
Physiology
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  SUMO1 modification of PKD2 channels regulates arterial contractility
  Raquibul Hasan, M. Dennis Leo, Padmapriya Muralidharan, Alejandro Mata-Daboin, Wen Yin, Simon Bulley, Carlos Fernandez-Peña, Charles E. MacKay, and Jonathan H. Jaggar
  
  PNAS December 26, 2019 116 (52) 27095-27104; first published December 10, 2019. https://doi.org/10.1073/pnas.1917264116
Plant Biology
- Open Access
  A noncanonical vacuolar sugar transferase required for biosynthesis of antimicrobial defense compounds in oat
  Anastasia Orme, Thomas Louveau, Michael J. Stephenson, Ingo Appelhagen, Rachel Melton, Jitender Cheema, Yan Li, Qiang Zhao, Lei Zhang, Danlin Fan, Qilin Tian, Robert J. Vickerstaff, Tim Langdon, Bin Han, and Anne Osbourn
  
  PNAS December 26, 2019 116 (52) 27105-27114; first published December 5, 2019. https://doi.org/10.1073/pnas.1914652116
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  The γ-tubulin complex protein GCP6 is crucial for spindle morphogenesis but not essential for microtubule reorganization in Arabidopsis
  Huiying Miao, Rongfang Guo, Junlin Chen, Qiaomei Wang, Yuh-Ru Julie Lee, and Bo Liu
  
  PNAS December 26, 2019 116 (52) 27115-27123; first published December 9, 2019. https://doi.org/10.1073/pnas.1912240116
- Open Access
  Transcriptomic analysis of field-droughted sorghum from seedling to maturity reveals biotic and metabolic responses
  Nelle Varoquaux, Benjamin Cole, Cheng Gao, Grady Pierroz, Christopher R. Baker, Dhruv Patel, Mary Madera, Tim Jeffers, Joy Hollingsworth, Julie Sievert, Yuko Yoshinaga, Judith A. Owiti, Vasanth R. Singan, Stephanie DeGraaf, Ling Xu, Matthew J. Blow, Maria J. Harrison, Axel Visel, Christer Jansson, Krishna K. Niyogi, Robert Hutmacher, Devin Coleman-Derr, Ronan C. O’Malley, John W. Taylor, Jeffery Dahlberg, John P. Vogel, Peggy G. Lemaux, and Elizabeth Purdom
  
  PNAS December 26, 2019 116 (52) 27124-27132; first published December 5, 2019. https://doi.org/10.1073/pnas.1907500116
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  Cryptochrome 2 competes with COP1 substrates to repress COP1 ubiquitin ligase activity during Arabidopsis photomorphogenesis
  Jathish Ponnu, Tabea Riedel, Eva Penner, Andrea Schrader, and Ute Hoecker
  
  PNAS December 26, 2019 116 (52) 27133-27141; first published December 10, 2019. https://doi.org/10.1073/pnas.1909181116
Population Biology
- Open Access
  Virus–virus interactions impact the population dynamics of influenza and the common cold
  Sema Nickbakhsh, Colette Mair, Louise Matthews, Richard Reeve, Paul C. D. Johnson, Fiona Thorburn, Beatrix von Wissmann, Arlene Reynolds, James McMenamin, Rory N. Gunson, and Pablo R. Murcia
  
  PNAS December 26, 2019 116 (52) 27142-27150; first published December 16, 2019. https://doi.org/10.1073/pnas.1911083116
  
  See companion article:
  Reply to Kloepfer and Gern: Independent studies suggest an arms race between influenza and rhinovirus: What next?
  - Mar 03, 2020
Sustainability Science
- Open Access
  Sixteen years of social and ecological dynamics reveal challenges and opportunities for adaptive management in sustaining the commons
  J. E. Cinner, J. D. Lau, A. G. Bauman, D. A. Feary, F. A. Januchowski-Hartley, C. A. Rojas, M. L. Barnes, B. J. Bergseth, E. Shum, R. Lahari, J. Ben, and N. A. J. Graham
  
  PNAS December 26, 2019 116 (52) 26474-26483; first published December 16, 2019. https://doi.org/10.1073/pnas.1914812116
Systems Biology
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  Deep learning for inferring gene relationships from single-cell expression data
  Ye Yuan and Ziv Bar-Joseph
  
  PNAS December 26, 2019 116 (52) 27151-27158; first published December 10, 2019. https://doi.org/10.1073/pnas.1911536116

Corrections

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Correction for Kumra et al., Fibulin-4 exerts a dual role in LTBP-4L–mediated matrix assembly and function
PNAS December 26, 2019 116 (52) 27159; first published December 16, 2019. https://doi.org/10.1073/pnas.1920843117
You have access
Correction for Fan et al., Abscisic acid regulation of guard-cell K⁺ and anion channels in Gβ- and RGS-deficient Arabidopsis lines
PNAS December 26, 2019 116 (52) 27160-27161; first published December 23, 2019. https://doi.org/10.1073/pnas.1920065116
You have access
Correction for de la Cuesta et al., Oil and aid revenue produce equal demands for accountability as taxes in Ghana and Uganda
PNAS December 26, 2019 116 (52) 27162; first published December 16, 2019. https://doi.org/10.1073/pnas.1920067116
You have access
Correction for Duckworth et al., Cognitive and noncognitive predictors of success
PNAS December 26, 2019 116 (52) 27163; first published December 16, 2019. https://doi.org/10.1073/pnas.1920625117

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