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Table of Contents
December 26, 2019; vol. 116 no. 52
This Week in PNAS
Guest Editor and Reviewer Acknowledgments (Online Only)
Opinion
Leading scientists discuss current issues.
- You have accessOpinion: Why green “climate gentrification” threatens poor and vulnerable populations
- Front Matter
Isabelle Anguelovski, James J. T. Connolly, Hamil Pearsall, Galia Shokry, Melissa Checker, Juliana Maantay, Kenneth Gould, Tammy Lewis, Andrew Maroko, and J. Timmons Roberts
Profile
- You have accessProfile of Dennis L. KasperJennifer ViegasPNAS December 26, 2019 116 (52) 26144-26146; first published December 2, 2019. https://doi.org/10.1073/pnas.1920088116
See companion article:
Letters
- You have accessCa2+/CaM interaction with voltage-gated Na+ channelsGeoffrey S. Pitt and Seok-Yong LeePNAS December 26, 2019 116 (52) 26150-26151; first published December 3, 2019. https://doi.org/10.1073/pnas.1909835116
- Open AccessReply to Pitt and Lee: Occupancies of Ca2+ in complexes of calmodulin with voltage-gated sodium channelsFilip Van Petegem and Bernd R. GardillPNAS December 26, 2019 116 (52) 26152; first published December 3, 2019. https://doi.org/10.1073/pnas.1918159116
See companion article:
- You have accessUrban heating and canopy cover need to be considered as matters of environmental justiceMichael DrescherPNAS December 26, 2019 116 (52) 26153-26154; first published December 17, 2019. https://doi.org/10.1073/pnas.1917213116
- You have accessReply to Drescher: Interdisciplinary collaboration is essential to understand and implement climate-resilient strategies in citiesCarly D. Ziter, Eric J. Pedersen, Christopher J. Kucharik, and Monica G. TurnerPNAS December 26, 2019 116 (52) 26155-26156; first published December 17, 2019. https://doi.org/10.1073/pnas.1918746116
See companion article:
Arthur M. Sackler Colloquium on Using Monkey Models to Understand and Develop Treatments for Human Brain Disorders (Free Online)
Introduction
- You have accessFrom basic brain research to treating human brain disorders
- From the Cover
Elizabeth A. Buffalo, J. Anthony Movshon, and Robert H. WurtzPNAS December 26, 2019 116 (52) 26167-26172; first published December 23, 2019. https://doi.org/10.1073/pnas.1919895116
Colloquium Papers
BRAINS AND BEHAVIOR: MICE, MONKEYS AND HUMANS
- You have accessCerebral cortical folding, parcellation, and connectivity in humans, nonhuman primates, and miceDavid C. Van Essen, Chad J. Donahue, Timothy S. Coalson, Henry Kennedy, Takuya Hayashi, and Matthew F. GlasserPNAS December 26, 2019 116 (52) 26173-26180; first published December 23, 2019. https://doi.org/10.1073/pnas.1902299116
- You have accessTranslational implications of the anatomical nonequivalence of functionally equivalent cholinergic circuit motifsAnita A. Disney and Jason S. RobertPNAS December 26, 2019 116 (52) 26181-26186; first published December 23, 2019. https://doi.org/10.1073/pnas.1902280116
- You have accessAttention can be subdivided into neurobiological components corresponding to distinct behavioral effectsThomas Zhihao Luo and John H. R. MaunsellPNAS December 26, 2019 116 (52) 26187-26194; first published December 23, 2019. https://doi.org/10.1073/pnas.1902286116
- You have accessPrimate optogenetics: Progress and prognosisYasmine El-Shamayleh and Gregory D. HorwitzPNAS December 26, 2019 116 (52) 26195-26203; first published December 23, 2019. https://doi.org/10.1073/pnas.1902284116
DISORDERS OF DEVELOPMENT
- You have accessContributions of nonhuman primate research to understanding the consequences of human brain injury during developmentFrancesca Cacucci and Faraneh Vargha-KhademPNAS December 26, 2019 116 (52) 26204-26209; first published December 23, 2019. https://doi.org/10.1073/pnas.1912952116
- You have accessNonhuman primate models of hippocampal development and dysfunctionJocelyne BachevalierPNAS December 26, 2019 116 (52) 26210-26216; first published December 23, 2019. https://doi.org/10.1073/pnas.1902278116
- You have accessUnderstanding the development of amblyopia using macaque monkey modelsLynne KiorpesPNAS December 26, 2019 116 (52) 26217-26223; first published December 23, 2019. https://doi.org/10.1073/pnas.1902285116
DISORDERS OF AGING
- You have accessAlzheimer’s disease: A clinical perspective and future nonhuman primate research opportunitiesRafi U. Haque and Allan I. LeveyPNAS December 26, 2019 116 (52) 26224-26229; first published December 23, 2019. https://doi.org/10.1073/pnas.1912954116
- You have accessAlzheimer’s-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer’s diseaseAmy F. T. Arnsten, Dibyadeep Datta, Shannon Leslie, Sheng-Tao Yang, Min Wang, and Angus C. NairnPNAS December 26, 2019 116 (52) 26230-26238; first published December 23, 2019. https://doi.org/10.1073/pnas.1903671116
- You have accessOligomeric Aβ in the monkey brain impacts synaptic integrity and induces accelerated cortical agingDanielle Beckman, Sean Ott, Kristine Donis-Cox, William G. Janssen, Eliza Bliss-Moreau, Peter H. Rudebeck, Mark G. Baxter, and John H. MorrisonPNAS December 26, 2019 116 (52) 26239-26246; first published December 23, 2019. https://doi.org/10.1073/pnas.1902301116
- You have accessExperiments in macaque monkeys provide critical insights into age-associated changes in cognitive and sensory functionDaniel T. Gray and Carol A. BarnesPNAS December 26, 2019 116 (52) 26247-26254; first published December 23, 2019. https://doi.org/10.1073/pnas.1902279116
RESTORING MOTOR AND SENSORY FUNCTION
- You have accessThe neurology clinic needs monkey researchMichael E. GoldbergPNAS December 26, 2019 116 (52) 26255-26258; first published December 23, 2019. https://doi.org/10.1073/pnas.1907759116
- You have accessUnderstanding Parkinson’s disease and deep brain stimulation: Role of monkey modelsJerrold L. Vitek and Luke A. JohnsonPNAS December 26, 2019 116 (52) 26259-26265; first published December 23, 2019. https://doi.org/10.1073/pnas.1902300116
- You have accessDistributed processing of movement signalingScott D. Kennedy and Andrew B. SchwartzPNAS December 26, 2019 116 (52) 26266-26273; first published December 23, 2019. https://doi.org/10.1073/pnas.1902296116
- You have accessFrom thought to action: The brain–machine interface in posterior parietal cortexRichard A. Andersen, Tyson Aflalo, and Spencer KellisPNAS December 26, 2019 116 (52) 26274-26279; first published December 23, 2019. https://doi.org/10.1073/pnas.1902276116
- You have accessThe primate model for understanding and restoring visionSerge Picaud, Deniz Dalkara, Katia Marazova, Olivier Goureau, Botond Roska, and José-Alain SahelPNAS December 26, 2019 116 (52) 26280-26287; first published December 23, 2019. https://doi.org/10.1073/pnas.1902292116
DISORDERS OF MOOD
- You have accessFrom bed to bench side: Reverse translation to optimize neuromodulation for mood disordersPeter H. Rudebeck, Erin L. Rich, and Helen S. MaybergPNAS December 26, 2019 116 (52) 26288-26296; first published December 23, 2019. https://doi.org/10.1073/pnas.1902287116
- You have accessWhy we need nonhuman primates to study the role of ventromedial prefrontal cortex in the regulation of threat- and reward-elicited responsesAngela C. Roberts and Hannah F. ClarkePNAS December 26, 2019 116 (52) 26297-26304; first published December 23, 2019. https://doi.org/10.1073/pnas.1902288116
- You have accessThe contribution of nonhuman primate research to the understanding of emotion and cognition and its clinical relevanceSilvia Bernardi and C. Daniel SalzmanPNAS December 26, 2019 116 (52) 26305-26312; first published December 23, 2019. https://doi.org/10.1073/pnas.1902293116
- You have accessMultiple neuronal circuits for variable object–action choices based on short- and long-term memoriesOkihide Hikosaka, Masaharu Yasuda, Kae Nakamura, Masaki Isoda, Hyoung F. Kim, Yasuo Terao, Hidetoshi Amita, and Kazutaka MaedaPNAS December 26, 2019 116 (52) 26313-26320; first published December 23, 2019. https://doi.org/10.1073/pnas.1902283116
- You have accessThe mind–body problem: Circuits that link the cerebral cortex to the adrenal medullaRichard P. Dum, David J. Levinthal, and Peter L. StrickPNAS December 26, 2019 116 (52) 26321-26328; first published December 23, 2019. https://doi.org/10.1073/pnas.1902297116
Brief Report
- Open AccessReactivation of critical period plasticity in adult auditory cortex through chemogenetic silencing of parvalbumin-positive interneuronsJ. Miguel Cisneros-Franco and Étienne de Villers-SidaniPNAS December 26, 2019 116 (52) 26329-26331; first published December 16, 2019. https://doi.org/10.1073/pnas.1913227117
Physical Sciences
Applied Mathematics
- You have accessA formula for the value of a stochastic gameLuc Attia and Miquel Oliu-BartonPNAS December 26, 2019 116 (52) 26435-26443; first published December 16, 2019. https://doi.org/10.1073/pnas.1908643116
Applied Physical Sciences
- Open AccessSono-optogenetics facilitated by a circulation-delivered rechargeable light source for minimally invasive optogeneticsXiang Wu, Xingjun Zhu, Paul Chong, Junlang Liu, Louis N. Andre, Kyrstyn S. Ong, Kenneth Brinson Jr, Ali I. Mahdi, Jiachen Li, Lief E. Fenno, Huiliang Wang, and Guosong HongPNAS December 26, 2019 116 (52) 26332-26342; first published December 6, 2019. https://doi.org/10.1073/pnas.1914387116
- Open AccessAutonomous bioluminescence imaging of single mammalian cells with the bacterial bioluminescence system
- From the Cover
Carola Gregor, Jasmin K. Pape, Klaus C. Gwosch, Tanja Gilat, Steffen J. Sahl, and Stefan W. HellPNAS December 26, 2019 116 (52) 26491-26496; first published December 2, 2019. https://doi.org/10.1073/pnas.1913616116
Biophysics and Computational Biology
- You have accessAnticipating critical transitions in epithelial–hybrid-mesenchymal cell-fate determinationSukanta Sarkar, Sudipta Kumar Sinha, Herbert Levine, Mohit Kumar Jolly, and Partha Sharathi DuttaPNAS December 26, 2019 116 (52) 26343-26352; first published December 16, 2019. https://doi.org/10.1073/pnas.1913773116
- You have accessMechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1Petros Giastas, Anastasia Mpakali, Athanasios Papakyriakou, Aggelos Lelis, Paraskevi Kokkala, Margarete Neu, Paul Rowland, John Liddle, Dimitris Georgiadis, and Efstratios StratikosPNAS December 26, 2019 116 (52) 26709-26716; first published December 16, 2019. https://doi.org/10.1073/pnas.1912070116
- Open AccessPrecise timing is ubiquitous, consistent, and coordinated across a comprehensive, spike-resolved flight motor programJoy Putney, Rachel Conn, and Simon SponbergPNAS December 26, 2019 116 (52) 26951-26960; first published December 16, 2019. https://doi.org/10.1073/pnas.1907513116
Chemistry
- You have accessSteering CO2 electroreduction toward ethanol production by a surface-bound Ru polypyridyl carbene catalyst on N-doped porous carbonYanming Liu, Xinfei Fan, Animesh Nayak, Ying Wang, Bing Shan, Xie Quan, and Thomas J. MeyerPNAS December 26, 2019 116 (52) 26353-26358; first published December 10, 2019. https://doi.org/10.1073/pnas.1907740116
- Open AccessNanoscale spectroscopic origins of photoinduced tip–sample force in the midinfraredJunghoon Jahng, Eric O. Potma, and Eun Seong LeePNAS December 26, 2019 116 (52) 26359-26366; first published December 11, 2019. https://doi.org/10.1073/pnas.1913729116
Computer Sciences
- Open AccessIndividual structural features constrain the mouse functional connectomeFrancesca Melozzi, Eyal Bergmann, Julie A. Harris, Itamar Kahn, Viktor Jirsa, and Christophe BernardPNAS December 26, 2019 116 (52) 26961-26969; first published December 11, 2019. https://doi.org/10.1073/pnas.1906694116
- You have accessDeep learning for inferring gene relationships from single-cell expression dataYe Yuan and Ziv Bar-JosephPNAS December 26, 2019 116 (52) 27151-27158; first published December 10, 2019. https://doi.org/10.1073/pnas.1911536116
Earth, Atmospheric, and Planetary Sciences
- Open AccessTriple junction kinematics accounts for the 2016 Mw 7.8 Kaikoura earthquake rupture complexityXuhua Shi, Paul Tapponnier, Teng Wang, Shengji Wei, Yu Wang, Xin Wang, and Liqing JiaoPNAS December 26, 2019 116 (52) 26367-26375; first published December 10, 2019. https://doi.org/10.1073/pnas.1916770116
- You have accessSatellite observations reveal extreme methane leakage from a natural gas well blowoutSudhanshu Pandey, Ritesh Gautam, Sander Houweling, Hugo Denier van der Gon, Pankaj Sadavarte, Tobias Borsdorff, Otto Hasekamp, Jochen Landgraf, Paul Tol, Tim van Kempen, Ruud Hoogeveen, Richard van Hees, Steven P. Hamburg, Joannes D. Maasakkers, and Ilse AbenPNAS December 26, 2019 116 (52) 26376-26381; first published December 16, 2019. https://doi.org/10.1073/pnas.1908712116
- You have accessDisappearance of the last tropical glaciers in the Western Pacific Warm Pool (Papua, Indonesia) appears imminentDonaldi S. Permana, Lonnie G. Thompson, Ellen Mosley-Thompson, Mary E. Davis, Ping-Nan Lin, Julien P. Nicolas, John F. Bolzan, Broxton W. Bird, Vladimir N. Mikhalenko, Paolo Gabrielli, Victor Zagorodnov, Keith R. Mountain, Ulrich Schotterer, Wido Hanggoro, Muhammad N. Habibie, Yohanes Kaize, Dodo Gunawan, Gesang Setyadi, Raden D. Susanto, Alfonso Fernández, and Bryan G. MarkPNAS December 26, 2019 116 (52) 26382-26388; first published December 9, 2019. https://doi.org/10.1073/pnas.1822037116
- You have accessAnisotropic diffusion creep in postperovskite provides a new model for deformation at the core−mantle boundaryDavid P. Dobson, Alexander Lindsay-Scott, Simon A. Hunt, Edward Bailey, Ian G. Wood, John P. Brodholt, Lidunka Vocadlo, and John WheelerPNAS December 26, 2019 116 (52) 26389-26393; first published December 11, 2019. https://doi.org/10.1073/pnas.1914826116
- You have accessMicrobial chemolithotrophy mediates oxidative weathering of granitic bedrockStephanie A. Napieralski, Heather L. Buss, Susan L. Brantley, Seungyeol Lee, Huifang Xu, and Eric E. RodenPNAS December 26, 2019 116 (52) 26394-26401; first published December 16, 2019. https://doi.org/10.1073/pnas.1909970117
Engineering
- You have accessTemperature-independent thermal radiationAlireza Shahsafi, Patrick Roney, You Zhou, Zhen Zhang, Yuzhe Xiao, Chenghao Wan, Raymond Wambold, Jad Salman, Zhaoning Yu, Jiarui Li, Jerzy T. Sadowski, Riccardo Comin, Shriram Ramanathan, and Mikhail A. KatsPNAS December 26, 2019 116 (52) 26402-26406; first published December 17, 2019. https://doi.org/10.1073/pnas.1911244116
- You have accessProgrammable active kirigami metasheets with more freedom of actuationYichao Tang, Yanbin Li, Yaoye Hong, Shu Yang, and Jie YinPNAS December 26, 2019 116 (52) 26407-26413; first published December 16, 2019. https://doi.org/10.1073/pnas.1906435116
- Open AccessDeep learning predicts path-dependent plasticityM. Mozaffar, R. Bostanabad, W. Chen, K. Ehmann, J. Cao, and M. A. BessaPNAS December 26, 2019 116 (52) 26414-26420; first published December 16, 2019. https://doi.org/10.1073/pnas.1911815116
- You have accessPerformance-advantaged ether diesel bioblendstock production by a priori designNabila A. Huq, Xiangchen Huo, Glenn R. Hafenstine, Stephen M. Tifft, Jim Stunkel, Earl D. Christensen, Gina M. Fioroni, Lisa Fouts, Robert L. McCormick, Patrick A. Cherry, Charles S. McEnally, Lisa D. Pfefferle, Matthew R. Wiatrowski, P. Thathiana Benavides, Mary J. Biddy, Raynella M. Connatser, Michael D. Kass, Teresa L. Alleman, Peter C. St. John, Seonah Kim, and Derek R. VardonPNAS December 26, 2019 116 (52) 26421-26430; first published December 16, 2019. https://doi.org/10.1073/pnas.1911107116
Physics
- You have accessUniversal Fermi-surface anisotropy renormalization for interacting Dirac fermions with long-range interactionsJia Ning Leaw, Ho-Kin Tang, Maxim Trushin, Fakher F. Assaad, and Shaffique AdamPNAS December 26, 2019 116 (52) 26431-26434; first published December 9, 2019. https://doi.org/10.1073/pnas.1913096116
Sustainability Science
- Open AccessProvincial and sector-level material footprints in ChinaMeng Jiang, Paul Behrens, Tao Wang, Zhipeng Tang, Yadong Yu, Dingjiang Chen, Lin Liu, Zijian Ren, Wenji Zhou, Shengjun Zhu, Canfei He, Arnold Tukker, and Bing ZhuPNAS December 26, 2019 116 (52) 26484-26490; first published December 16, 2019. https://doi.org/10.1073/pnas.1903028116
Social Sciences
Economic Sciences
- You have accessA formula for the value of a stochastic gameLuc Attia and Miquel Oliu-BartonPNAS December 26, 2019 116 (52) 26435-26443; first published December 16, 2019. https://doi.org/10.1073/pnas.1908643116
- Open AccessClimate variability reduces employment in New England fisheriesKimberly L. OremusPNAS December 26, 2019 116 (52) 26444-26449; first published December 9, 2019. https://doi.org/10.1073/pnas.1820154116
Environmental Sciences
- You have accessPersistent, bioaccumulative, and toxic properties of liquid crystal monomers and their detection in indoor residential dustHuijun Su, Shaobo Shi, Ming Zhu, Doug Crump, Robert J. Letcher, John P. Giesy, and Guanyong SuPNAS December 26, 2019 116 (52) 26450-26458; first published December 9, 2019. https://doi.org/10.1073/pnas.1915322116
Psychological and Cognitive Sciences
- Open AccessSocial media-predicted personality traits and values can help match people to their ideal jobsMargaret L. Kern, Paul X. McCarthy, Deepanjan Chakrabarty, and Marian-Andrei RizoiuPNAS December 26, 2019 116 (52) 26459-26464; first published December 16, 2019. https://doi.org/10.1073/pnas.1917942116
- You have accessVentral hippocampus interacts with prelimbic cortex during inhibition of threat response via learned safety in both mice and humansHeidi C. Meyer, Paola Odriozola, Emily M. Cohodes, Jeffrey D. Mandell, Anfei Li, Ruirong Yang, Baila S. Hall, Jason T. Haberman, Sadie J. Zacharek, Conor Liston, Francis S. Lee, and Dylan G. GeePNAS December 26, 2019 116 (52) 26970-26979; first published December 10, 2019. https://doi.org/10.1073/pnas.1910481116
Sustainability Science
- You have accessA social–ecological analysis of the global agrifood systemElisa Oteros-Rozas, Adriana Ruiz-Almeida, Mateo Aguado, José A. González, and Marta G. Rivera-FerrePNAS December 26, 2019 116 (52) 26465-26473; first published December 16, 2019. https://doi.org/10.1073/pnas.1912710116
- Open AccessSixteen years of social and ecological dynamics reveal challenges and opportunities for adaptive management in sustaining the commonsJ. E. Cinner, J. D. Lau, A. G. Bauman, D. A. Feary, F. A. Januchowski-Hartley, C. A. Rojas, M. L. Barnes, B. J. Bergseth, E. Shum, R. Lahari, J. Ben, and N. A. J. GrahamPNAS December 26, 2019 116 (52) 26474-26483; first published December 16, 2019. https://doi.org/10.1073/pnas.1914812116
- Open AccessProvincial and sector-level material footprints in ChinaMeng Jiang, Paul Behrens, Tao Wang, Zhipeng Tang, Yadong Yu, Dingjiang Chen, Lin Liu, Zijian Ren, Wenji Zhou, Shengjun Zhu, Canfei He, Arnold Tukker, and Bing ZhuPNAS December 26, 2019 116 (52) 26484-26490; first published December 16, 2019. https://doi.org/10.1073/pnas.1903028116
Biological Sciences
Biochemistry
- Open AccessAutonomous bioluminescence imaging of single mammalian cells with the bacterial bioluminescence system
- From the Cover
Carola Gregor, Jasmin K. Pape, Klaus C. Gwosch, Tanja Gilat, Steffen J. Sahl, and Stefan W. HellPNAS December 26, 2019 116 (52) 26491-26496; first published December 2, 2019. https://doi.org/10.1073/pnas.1913616116 - You have accessMolybdate pumping into the molybdenum storage protein via an ATP-powered piercing mechanismSteffen Brünle, Martin L. Eisinger, Juliane Poppe, Deryck J. Mills, Julian D. Langer, Janet Vonck, and Ulrich ErmlerPNAS December 26, 2019 116 (52) 26497-26504; first published December 6, 2019. https://doi.org/10.1073/pnas.1913031116
- You have accessCombining conservation and species-specific differences to determine how human telomerase binds telomeresValerie M. Tesmer, Eric M. Smith, Oana Danciu, Shilpa Padmanaban, and Jayakrishnan NandakumarPNAS December 26, 2019 116 (52) 26505-26515; first published December 10, 2019. https://doi.org/10.1073/pnas.1911912116
- Open AccessThe antimicrobial peptide ZY4 combats multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii infectionJames Mwangi, Yizhu Yin, Gan Wang, Min Yang, Ya Li, Zhiye Zhang, and Ren LaiPNAS December 26, 2019 116 (52) 26516-26522; first published December 16, 2019. https://doi.org/10.1073/pnas.1909585117
- Open AccessApproaching infinite affinity through engineering of peptide–protein interactionAnthony H. Keeble, Paula Turkki, Samuel Stokes, Irsyad N. A. Khairil Anuar, Rolle Rahikainen, Vesa P. Hytönen, and Mark HowarthPNAS December 26, 2019 116 (52) 26523-26533; first published December 10, 2019. https://doi.org/10.1073/pnas.1909653116
Biophysics and Computational Biology
- You have accessAnticipating critical transitions in epithelial–hybrid-mesenchymal cell-fate determinationSukanta Sarkar, Sudipta Kumar Sinha, Herbert Levine, Mohit Kumar Jolly, and Partha Sharathi DuttaPNAS December 26, 2019 116 (52) 26343-26352; first published December 16, 2019. https://doi.org/10.1073/pnas.1913773116
- Open AccessSupercoiling DNA opticallyGraeme A. King, Federica Burla, Erwin J. G. Peterman, and Gijs J. L. WuitePNAS December 26, 2019 116 (52) 26534-26539; first published December 5, 2019. https://doi.org/10.1073/pnas.1908826116
- Open AccessDefining the remarkable structural malleability of a bacterial surface protein Rib domain implicated in infectionFiona Whelan, Aleix Lafita, Samuel C. Griffiths, Rachael E. M. Cooper, Jean L. Whittingham, Johan P. Turkenburg, Iain W. Manfield, Alexander N. St. John, Emanuele Paci, Alex Bateman, and Jennifer R. PottsPNAS December 26, 2019 116 (52) 26540-26548; first published December 9, 2019. https://doi.org/10.1073/pnas.1911776116
- You have accessValproic acid interactions with the NavMs voltage-gated sodium channelGeancarlo Zanatta, Altin Sula, Andrew J. Miles, Leo C. T. Ng, Rubben Torella, David C. Pryde, Paul G. DeCaen, and B. A. WallacePNAS December 26, 2019 116 (52) 26549-26554; first published December 10, 2019. https://doi.org/10.1073/pnas.1909696116
- You have accessIncreased stiffness and flow resistance of the inner wall of Schlemm’s canal in glaucomatous human eyesAmir Vahabikashi, Ariel Gelman, Biqin Dong, Lihua Gong, Elliott D. K. Cha, Margit Schimmel, Ernst R. Tamm, Kristin Perkumas, W. Daniel Stamer, Cheng Sun, Hao F. Zhang, Haiyan Gong, and Mark JohnsonPNAS December 26, 2019 116 (52) 26555-26563; first published December 5, 2019. https://doi.org/10.1073/pnas.1911837116
- You have accessMicrotubule binding kinetics of membrane-bound kinesin-1 predicts high motor copy numbers on intracellular cargoRui Jiang, Steven Vandal, SooHyun Park, Sheereen Majd, Erkan Tüzel, and William O. HancockPNAS December 26, 2019 116 (52) 26564-26570; first published December 10, 2019. https://doi.org/10.1073/pnas.1916204116
- You have accessOn the possible origin of protein homochirality, structure, and biochemical functionJeffrey Skolnick, Hongyi Zhou, and Mu GaoPNAS December 26, 2019 116 (52) 26571-26579; first published December 10, 2019. https://doi.org/10.1073/pnas.1908241116
Cell Biology
- You have accessPancreatic cancer organoids recapitulate disease and allow personalized drug screeningElse Driehuis, Arne van Hoeck, Kat Moore, Sigrid Kolders, Hayley E. Francies, M. Can Gulersonmez, Edwin C. A. Stigter, Boudewijn Burgering, Veerle Geurts, Ana Gracanin, Gergana Bounova, Folkert H. Morsink, Robert Vries, Sylvia Boj, Johan van Es, G. Johan A. Offerhaus, Onno Kranenburg, Mathew J. Garnett, Lodewyk Wessels, Edwin Cuppen, Lodewijk A. A. Brosens, and Hans CleversPNAS December 26, 2019 116 (52) 26580-26590; first published December 9, 2019. https://doi.org/10.1073/pnas.1911273116
- You have accessThe role of translationally controlled tumor protein in proliferation of Drosophila intestinal stem cellsYoung V. Kwon, Bingqing Zhao, Chiwei Xu, Jiae Lee, Chiao-Lin Chen, Arunachalam Vinayagam, Bruce A. Edgar, and Norbert PerrimonPNAS December 26, 2019 116 (52) 26591-26598; first published December 16, 2019. https://doi.org/10.1073/pnas.1910850116
- You have accessEnteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletionJohan H. van Es, Kay Wiebrands, Carmen López-Iglesias, Marc van de Wetering, Laura Zeinstra, Maaike van den Born, Jeroen Korving, Nobuo Sasaki, Peter J. Peters, Alexander van Oudenaarden, and Hans CleversPNAS December 26, 2019 116 (52) 26599-26605; first published December 16, 2019. https://doi.org/10.1073/pnas.1801888117
- Open AccessLoss of p57KIP2 expression confers resistance to contact inhibition in human androgenetic trophoblast stem cellsSota Takahashi, Hiroaki Okae, Norio Kobayashi, Akane Kitamura, Kanako Kumada, Nobuo Yaegashi, and Takahiro ArimaPNAS December 26, 2019 116 (52) 26606-26613; first published December 2, 2019. https://doi.org/10.1073/pnas.1916019116
- Open AccessReactivation of Epstein–Barr virus by a dual-responsive fluorescent EBNA1-targeting agent with Zn2+-chelating functionLijun Jiang, Hong Lok Lung, Tao Huang, Rongfeng Lan, Shuai Zha, Lai Sheung Chan, Waygen Thor, Tik-Hung Tsoi, Ho-Fai Chau, Cecilia Boreström, Steven L. Cobb, Sai Wah Tsao, Zhao-Xiang Bian, Ga-Lai Law, Wing-Tak Wong, William Chi-Shing Tai, Wai Yin Chau, Yujun Du, Lucas Hao Xi Tang, Alan Kwok Shing Chiang, Jaap M. Middeldorp, Kwok-Wai Lo, Nai Ki Mak, Nicholas J. Long, and Ka-Leung WongPNAS December 26, 2019 116 (52) 26614-26624; first published December 10, 2019. https://doi.org/10.1073/pnas.1915372116
- You have accessSIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesisKai Su Greene, Michael J. Lukey, Xueying Wang, Bryant Blank, Joseph E. Druso, Miao-chong J. Lin, Clint A. Stalnecker, Chengliang Zhang, Yashira Negrón Abril, Jon W. Erickson, Kristin F. Wilson, Hening Lin, Robert S. Weiss, and Richard A. CerionePNAS December 26, 2019 116 (52) 26625-26632; first published December 16, 2019. https://doi.org/10.1073/pnas.1911954116
- Open AccessPeripheral (not central) corneal epithelia contribute to the closure of an annular debridement injuryMijeong Park, Alexander Richardson, Elvis Pandzic, Erwin P. Lobo, J. Guy Lyons, and Nick Di GirolamoPNAS December 26, 2019 116 (52) 26633-26643; first published December 16, 2019. https://doi.org/10.1073/pnas.1912260116
- You have accessA cis-element within the ARF locus mediates repression of p16INK4A expression via long-range chromatin interactionsYang Zhang, Judith Hyle, Shaela Wright, Ying Shao, Xujie Zhao, Hui Zhang, and Chunliang LiPNAS December 26, 2019 116 (52) 26644-26652; first published December 9, 2019. https://doi.org/10.1073/pnas.1909720116
Ecology
- You have accessToward a metabolic theory of life historyJoseph Robert Burger, Chen Hou, and James H. BrownPNAS December 26, 2019 116 (52) 26653-26661; first published December 10, 2019. https://doi.org/10.1073/pnas.1907702116
- You have accessModeling active sensing reveals echo detection even in large groups of batsThejasvi Beleyur and Holger R. GoerlitzPNAS December 26, 2019 116 (52) 26662-26668; first published December 10, 2019. https://doi.org/10.1073/pnas.1821722116
- Open AccessPostreproductive killer whale grandmothers improve the survival of their grandoffspringStuart Nattrass, Darren P. Croft, Samuel Ellis, Michael A. Cant, Michael N. Weiss, Brianna M. Wright, Eva Stredulinsky, Thomas Doniol-Valcroze, John K. B. Ford, Kenneth C. Balcomb, and Daniel W. FranksPNAS December 26, 2019 116 (52) 26669-26673; first published December 9, 2019. https://doi.org/10.1073/pnas.1903844116
- Open AccessHuman activities have opposing effects on distributions of narrow-ranged and widespread plant species in ChinaWu-Bing Xu, Jens-Christian Svenning, Guo-Ke Chen, Ming-Gang Zhang, Ji-Hong Huang, Bin Chen, Alejandro Ordonez, and Ke-Ping MaPNAS December 26, 2019 116 (52) 26674-26681; first published December 16, 2019. https://doi.org/10.1073/pnas.1911851116
- Open AccessResurgence of an apex marine predator and the decline in prey body sizeJan Ohlberger, Daniel E. Schindler, Eric J. Ward, Timothy E. Walsworth, and Timothy E. EssingtonPNAS December 26, 2019 116 (52) 26682-26689; first published December 16, 2019. https://doi.org/10.1073/pnas.1910930116
Environmental Sciences
- Open AccessClimate variability reduces employment in New England fisheriesKimberly L. OremusPNAS December 26, 2019 116 (52) 26444-26449; first published December 9, 2019. https://doi.org/10.1073/pnas.1820154116
Evolution
- You have accessReceding ice drove parallel expansions in Southern Ocean penguinsTheresa L. Cole, Ludovic Dutoit, Nicolas Dussex, Tom Hart, Alana Alexander, Jane L. Younger, Gemma V. Clucas, María José Frugone, Yves Cherel, Richard Cuthbert, Ursula Ellenberg, Steven R. Fiddaman, Johanna Hiscock, David Houston, Pierre Jouventin, Thomas Mattern, Gary Miller, Colin Miskelly, Paul Nolan, Michael J. Polito, Petra Quillfeldt, Peter G. Ryan, Adrian Smith, Alan J. D. Tennyson, David Thompson, Barbara Wienecke, Juliana A. Vianna, and Jonathan M. WatersPNAS December 26, 2019 116 (52) 26690-26696; first published December 16, 2019. https://doi.org/10.1073/pnas.1904048116
Genetics
- You have accessGene- and tissue-level interactions in normal gastrointestinal development and Hirschsprung diseaseSumantra Chatterjee, Priyanka Nandakumar, Dallas R. Auer, Stacey B. Gabriel, and Aravinda ChakravartiPNAS December 26, 2019 116 (52) 26697-26708; first published December 9, 2019. https://doi.org/10.1073/pnas.1908756116
Immunology and Inflammation
- You have accessSymbionts exploit complex signaling to educate the immune system
- Inaugural Article
Deniz Erturk-Hasdemir, Sungwhan F. Oh, Nihal A. Okan, Giuseppe Stefanetti, Francesca S. Gazzaniga, Peter H. Seeberger, Scott E. Plevy, and Dennis L. KasperPNAS December 26, 2019 116 (52) 26157-26166; first published December 6, 2019. https://doi.org/10.1073/pnas.1915978116See companion article:
- Profile of Dennis L. Kasper- Dec 02, 2019
- You have accessMechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1Petros Giastas, Anastasia Mpakali, Athanasios Papakyriakou, Aggelos Lelis, Paraskevi Kokkala, Margarete Neu, Paul Rowland, John Liddle, Dimitris Georgiadis, and Efstratios StratikosPNAS December 26, 2019 116 (52) 26709-26716; first published December 16, 2019. https://doi.org/10.1073/pnas.1912070116
- You have accessNeutralization of IL-1α ameliorates Crohn’s disease-like ileitis by functional alterations of the gut microbiomePaola Menghini, Daniele Corridoni, Ludovica F. Buttó, Abdullah Osme, Sushma Shivaswamy, Minh Lam, Giorgos Bamias, Theresa T. Pizarro, Alexander Rodriguez-Palacios, Charles A. Dinarello, and Fabio CominelliPNAS December 26, 2019 116 (52) 26717-26726; first published December 16, 2019. https://doi.org/10.1073/pnas.1915043116
- You have accessT cell receptor specificity drives accumulation of a reparative population of regulatory T cells within acutely injured skeletal muscleJun Cho, Wilson Kuswanto, Christophe Benoist, and Diane MathisPNAS December 26, 2019 116 (52) 26727-26733; first published December 10, 2019. https://doi.org/10.1073/pnas.1914848116
- You have accessComprehensive analysis of a mouse model of spontaneous uveoretinitis using single-cell RNA sequencingJacob S. Heng, Sean F. Hackett, Genevieve L. Stein-O’Brien, Briana L. Winer, John Williams, Loyal A. Goff, and Jeremy NathansPNAS December 26, 2019 116 (52) 26734-26744; first published December 16, 2019. https://doi.org/10.1073/pnas.1915571116
- Open AccessAffinity maturation in a human humoral response to influenza hemagglutininKevin R. McCarthy, Donald D. Raymond, Khoi T. Do, Aaron G. Schmidt, and Stephen C. HarrisonPNAS December 26, 2019 116 (52) 26745-26751; first published December 16, 2019. https://doi.org/10.1073/pnas.1915620116
- You have accessIntermittent rolling is a defect of the extravasation cascade caused by Myosin1e-deficiency in neutrophilsEduardo Vadillo, Sandra Chánez-Paredes, Hilda Vargas-Robles, Idaira María Guerrero-Fonseca, Ramón Castellanos-Martínez, Alexander García-Ponce, Porfirio Nava, Daniel Alberto Girón-Pérez, Leopoldo Santos-Argumedo, and Michael SchnoorPNAS December 26, 2019 116 (52) 26752-26758; first published December 6, 2019. https://doi.org/10.1073/pnas.1902502116
- Open AccessEvolutionary transition from degenerate to nonredundant cytokine signaling networks supporting intrathymic T cell developmentDivine-Fondzenyuy Lawir, Isabell Hess, Katarzyna Sikora, Norimasa Iwanami, Iliana Siamishi, Michael Schorpp, and Thomas BoehmPNAS December 26, 2019 116 (52) 26759-26767; first published December 10, 2019. https://doi.org/10.1073/pnas.1915223116
- You have accessLy49R activation receptor drives self-MHC–educated NK cell immunity against cytomegalovirus infectionAwndre Gamache, John M. Cronk, William T. Nash, Patryk Puchalski, Alyssa Gillespie, Hairong Wei, Laurie Gray, Marie-Louise Hammarskjold, Wenhao Xu, and Michael G. BrownPNAS December 26, 2019 116 (52) 26768-26778; first published December 16, 2019. https://doi.org/10.1073/pnas.1913064117
- Open AccessParent-of-origin differences in DNA methylation of X chromosome genes in T lymphocytes
- From the Cover
Lisa C. Golden, Yuichiro Itoh, Noriko Itoh, Sonia Iyengar, Patrick Coit, Youstina Salama, Arthur P. Arnold, Amr H. Sawalha, and Rhonda R. VoskuhlPNAS December 26, 2019 116 (52) 26779-26787; first published December 10, 2019. https://doi.org/10.1073/pnas.1910072116 - You have accessActivation-induced cell death of self-reactive regulatory T cells drives autoimmunityEster Badami, Olivier N. F. Cexus, and Sonia QuaratinoPNAS December 26, 2019 116 (52) 26788-26797; first published December 9, 2019. https://doi.org/10.1073/pnas.1910281116
Medical Sciences
- You have accessCharacterization of splice-altering mutations in inherited predisposition to cancerSilvia Casadei, Suleyman Gulsuner, Brian H. Shirts, Jessica B. Mandell, Hannah M. Kortbawi, Barbara S. Norquist, Elizabeth M. Swisher, Ming K. Lee, Yael Goldberg, Robert O’Connor, Zheng Tan, Colin C. Pritchard, Mary-Claire King, and Tom WalshPNAS December 26, 2019 116 (52) 26798-26807; first published December 16, 2019. https://doi.org/10.1073/pnas.1915608116
- You have accessOxytocin regulates body compositionLi Sun, Daria Lizneva, Yaoting Ji, Graziana Colaianni, Elina Hadelia, Anisa Gumerova, Kseniia Ievleva, Tan-Chun Kuo, Funda Korkmaz, Vitaly Ryu, Alina Rahimova, Sakshi Gera, Charit Taneja, Ayesha Khan, Naseer Ahmad, Roberto Tamma, Zhuan Bian, Alberta Zallone, Se-Min Kim, Maria I. New, Jameel Iqbal, Tony Yuen, and Mone ZaidiPNAS December 26, 2019 116 (52) 26808-26815; first published December 16, 2019. https://doi.org/10.1073/pnas.1913611116
- Open AccessIgGs from patients with amyotrophic lateral sclerosis and diabetes target CaVα2δ1 subunits impairing islet cell function and survivalYue Shi, Kyoung Sun Park, Seung Hyun Kim, Jia Yu, Kaixuan Zhao, Lina Yu, Ki Wook Oh, Kayoung Lee, Jaeyoon Kim, Kanchan Chaggar, Yuxin Li, Annette C. Dolphin, William A. Catterall, Sung Ho Ryu, Shao-Nian Yang, and Per-Olof BerggrenPNAS December 26, 2019 116 (52) 26816-26822; first published December 11, 2019. https://doi.org/10.1073/pnas.1911956116
- You have accessFOXA1 upregulation promotes enhancer and transcriptional reprogramming in endocrine-resistant breast cancerXiaoyong Fu, Resel Pereira, Carmine De Angelis, Jamunarani Veeraraghavan, Sarmistha Nanda, Lanfang Qin, Maria L. Cataldo, Vidyalakshmi Sethunath, Sepideh Mehravaran, Carolina Gutierrez, Gary C. Chamness, Qin Feng, Bert W. O’Malley, Pier Selenica, Britta Weigelt, Jorge S. Reis-Filho, Ofir Cohen, Nikhil Wagle, Agostina Nardone, Rinath Jeselsohn, Myles Brown, Mothaffar F. Rimawi, C. Kent Osborne, and Rachel SchiffPNAS December 26, 2019 116 (52) 26823-26834; first published December 11, 2019. https://doi.org/10.1073/pnas.1911584116
- Open AccessEpithelial to mesenchymal plasticity and differential response to therapies in pancreatic ductal adenocarcinomaRebecca L. Porter, Neelima K. C. Magnus, Vishal Thapar, Robert Morris, Annamaria Szabolcs, Azfar Neyaz, Anupriya S. Kulkarni, Eric Tai, Abhijit Chougule, Alessandra Hillis, Gabriel Golczer, Hongshan Guo, Teppei Yamada, Tomohiro Kurokawa, Chittampalli Yashaswini, Matteo Ligorio, Kevin D. Vo, Linda Nieman, Andrew S. Liss, Vikram Deshpande, Michael S. Lawrence, Shyamala Maheswaran, Carlos Fernandez-Del Castillo, Theodore S. Hong, David P. Ryan, Peter J. O’Dwyer, Jeffrey A. Drebin, Cristina R. Ferrone, Daniel A. Haber, and David T. TingPNAS December 26, 2019 116 (52) 26835-26845; first published December 16, 2019. https://doi.org/10.1073/pnas.1914915116
- You have accessCRISPR/Cas9-based targeted genome editing for correction of recessive dystrophic epidermolysis bullosa using iPS cells
- From the Cover
Joanna Jacków, Zongyou Guo, Corey Hansen, Hasan E. Abaci, Yanne S. Doucet, Jung U Shin, Ryota Hayashi, Dominick DeLorenzo, Yudai Kabata, Satoru Shinkuma, Julio C. Salas-Alanis, and Angela M. ChristianoPNAS December 26, 2019 116 (52) 26846-26852; first published December 9, 2019. https://doi.org/10.1073/pnas.1907081116See companion article:
- Toward treatment and cure of epidermolysis bullosa- Dec 11, 2019
- You have accessThe emergence of classical BSE from atypical/Nor98 scrapieAlvina Huor, Juan Carlos Espinosa, Enric Vidal, Hervé Cassard, Jean-Yves Douet, Séverine Lugan, Naima Aron, Alba Marín-Moreno, Patricia Lorenzo, Patricia Aguilar-Calvo, Juan Badiola, Rosa Bolea, Martí Pumarola, Sylvie L. Benestad, Leonore Orge, Alana M. Thackray, Raymond Bujdoso, Juan-Maria Torres, and Olivier AndreolettiPNAS December 26, 2019 116 (52) 26853-26862; first published December 16, 2019. https://doi.org/10.1073/pnas.1915737116
- Open AccessExtensive subclonal mutational diversity in human colorectal cancer and its significanceLawrence A. Loeb, Brendan F. Kohrn, Kaitlyn J. Loubet-Senear, Yasmin J. Dunn, Eun Hyun Ahn, Jacintha N. O’Sullivan, Jesse J. Salk, Mary P. Bronner, and Robert A. BeckmanPNAS December 26, 2019 116 (52) 26863-26872; first published December 5, 2019. https://doi.org/10.1073/pnas.1910301116
- You have accessA tumorigenic index for quantitative analysis of liver cancer initiation and progressionGaowei Wang, Xiaolin Luo, Yan Liang, Kota Kaneko, Hairi Li, Xiang-Dong Fu, and Gen-Sheng FengPNAS December 26, 2019 116 (52) 26873-26880; first published December 16, 2019. https://doi.org/10.1073/pnas.1911193116
Microbiology
- You have accessEvolution of resistance in vitro reveals mechanisms of artemisinin activity in Toxoplasma gondiiAlex Rosenberg, Madeline R. Luth, Elizabeth A. Winzeler, Michael Behnke, and L. David SibleyPNAS December 26, 2019 116 (52) 26881-26891; first published December 5, 2019. https://doi.org/10.1073/pnas.1914732116
- You have accessExtracellular electron transfer powers flavinylated extracellular reductases in Gram-positive bacteriaSamuel H. Light, Raphaël Méheust, Jessica L. Ferrell, Jooyoung Cho, David Deng, Marco Agostoni, Anthony T. Iavarone, Jillian F. Banfield, Sarah E. F. D’Orazio, and Daniel A. PortnoyPNAS December 26, 2019 116 (52) 26892-26899; first published December 9, 2019. https://doi.org/10.1073/pnas.1915678116
- Open AccessCross-genotype protection of live-attenuated vaccine candidate for severe fever with thrombocytopenia syndrome virus in a ferret modelKwang-Min Yu, Su-Jin Park, Min-Ah Yu, Young-Il Kim, Younho Choi, Jae U. Jung, Benjamin Brennan, and Young Ki ChoiPNAS December 26, 2019 116 (52) 26900-26908; first published December 9, 2019. https://doi.org/10.1073/pnas.1914704116
- You have accessAntitumor astins originate from the fungal endophyte Cyanodermella asteris living within the medicinal plant Aster tataricusThomas Schafhauser, Linda Jahn, Norbert Kirchner, Andreas Kulik, Liane Flor, Alexander Lang, Thibault Caradec, David P. Fewer, Kaarina Sivonen, Willem J. H. van Berkel, Philippe Jacques, Tilmann Weber, Harald Gross, Karl-Heinz van Pée, Wolfgang Wohlleben, and Jutta Ludwig-MüllerPNAS December 26, 2019 116 (52) 26909-26917; first published December 6, 2019. https://doi.org/10.1073/pnas.1910527116
- You have accessA population shift between two heritable cell types of the pathogen Candida albicans is based both on switching and selective proliferationChiraj K. Dalal, Ignacio A. Zuleta, Matthew B. Lohse, Rebecca E. Zordan, Hana El-Samad, and Alexander D. JohnsonPNAS December 26, 2019 116 (52) 26918-26924; first published December 10, 2019. https://doi.org/10.1073/pnas.1908986116
- Open AccessAntimicrobial sensing coupled with cell membrane remodeling mediates antibiotic resistance and virulence in Enterococcus faecalisAyesha Khan, Milya Davlieva, Diana Panesso, Sandra Rincon, William R. Miller, Lorena Diaz, Jinnethe Reyes, Melissa R. Cruz, Orville Pemberton, April H. Nguyen, Sara D. Siegel, Paul J. Planet, Apurva Narechania, Mauricio Latorre, Rafael Rios, Kavindra V. Singh, Hung Ton-That, Danielle A. Garsin, Truc T. Tran, Yousif Shamoo, and Cesar A. AriasPNAS December 26, 2019 116 (52) 26925-26932; first published December 9, 2019. https://doi.org/10.1073/pnas.1916037116
- Open AccessViral neutralization by antibody-imposed physical disruptionQingbing Zheng, Jie Jiang, Maozhou He, Zizheng Zheng, Hai Yu, Tingting Li, Wenhui Xue, Zimin Tang, Dong Ying, Zekai Li, Shuo Song, Xinlin Liu, Kaihang Wang, Zhiqing Zhang, Daning Wang, Yingbin Wang, Xiaodong Yan, Qinjian Zhao, Jun Zhang, Ying Gu, Shaowei Li, and Ningshao XiaPNAS December 26, 2019 116 (52) 26933-26940; first published December 9, 2019. https://doi.org/10.1073/pnas.1916028116
- You have accessInhibition of ULK1 and Beclin1 by an α-herpesvirus Akt-like Ser/Thr kinase limits autophagy to stimulate virus replicationRosa M. Rubio and Ian MohrPNAS December 26, 2019 116 (52) 26941-26950; first published December 16, 2019. https://doi.org/10.1073/pnas.1915139116
Neuroscience
- You have accessCerebral cortical folding, parcellation, and connectivity in humans, nonhuman primates, and miceDavid C. Van Essen, Chad J. Donahue, Timothy S. Coalson, Henry Kennedy, Takuya Hayashi, and Matthew F. GlasserPNAS December 26, 2019 116 (52) 26173-26180; first published December 23, 2019. https://doi.org/10.1073/pnas.1902299116
- You have accessTranslational implications of the anatomical nonequivalence of functionally equivalent cholinergic circuit motifsAnita A. Disney and Jason S. RobertPNAS December 26, 2019 116 (52) 26181-26186; first published December 23, 2019. https://doi.org/10.1073/pnas.1902280116
- You have accessAttention can be subdivided into neurobiological components corresponding to distinct behavioral effectsThomas Zhihao Luo and John H. R. MaunsellPNAS December 26, 2019 116 (52) 26187-26194; first published December 23, 2019. https://doi.org/10.1073/pnas.1902286116
- You have accessPrimate optogenetics: Progress and prognosisYasmine El-Shamayleh and Gregory D. HorwitzPNAS December 26, 2019 116 (52) 26195-26203; first published December 23, 2019. https://doi.org/10.1073/pnas.1902284116
- You have accessNonhuman primate models of hippocampal development and dysfunctionJocelyne BachevalierPNAS December 26, 2019 116 (52) 26210-26216; first published December 23, 2019. https://doi.org/10.1073/pnas.1902278116
- You have accessUnderstanding the development of amblyopia using macaque monkey modelsLynne KiorpesPNAS December 26, 2019 116 (52) 26217-26223; first published December 23, 2019. https://doi.org/10.1073/pnas.1902285116
- You have accessAlzheimer’s-like pathology in aging rhesus macaques: Unique opportunity to study the etiology and treatment of Alzheimer’s diseaseAmy F. T. Arnsten, Dibyadeep Datta, Shannon Leslie, Sheng-Tao Yang, Min Wang, and Angus C. NairnPNAS December 26, 2019 116 (52) 26230-26238; first published December 23, 2019. https://doi.org/10.1073/pnas.1903671116
- You have accessOligomeric Aβ in the monkey brain impacts synaptic integrity and induces accelerated cortical agingDanielle Beckman, Sean Ott, Kristine Donis-Cox, William G. Janssen, Eliza Bliss-Moreau, Peter H. Rudebeck, Mark G. Baxter, and John H. MorrisonPNAS December 26, 2019 116 (52) 26239-26246; first published December 23, 2019. https://doi.org/10.1073/pnas.1902301116
- You have accessExperiments in macaque monkeys provide critical insights into age-associated changes in cognitive and sensory functionDaniel T. Gray and Carol A. BarnesPNAS December 26, 2019 116 (52) 26247-26254; first published December 23, 2019. https://doi.org/10.1073/pnas.1902279116
- You have accessUnderstanding Parkinson’s disease and deep brain stimulation: Role of monkey modelsJerrold L. Vitek and Luke A. JohnsonPNAS December 26, 2019 116 (52) 26259-26265; first published December 23, 2019. https://doi.org/10.1073/pnas.1902300116
- You have accessDistributed processing of movement signalingScott D. Kennedy and Andrew B. SchwartzPNAS December 26, 2019 116 (52) 26266-26273; first published December 23, 2019. https://doi.org/10.1073/pnas.1902296116
- You have accessFrom thought to action: The brain–machine interface in posterior parietal cortexRichard A. Andersen, Tyson Aflalo, and Spencer KellisPNAS December 26, 2019 116 (52) 26274-26279; first published December 23, 2019. https://doi.org/10.1073/pnas.1902276116
- You have accessThe primate model for understanding and restoring visionSerge Picaud, Deniz Dalkara, Katia Marazova, Olivier Goureau, Botond Roska, and José-Alain SahelPNAS December 26, 2019 116 (52) 26280-26287; first published December 23, 2019. https://doi.org/10.1073/pnas.1902292116
- You have accessWhy we need nonhuman primates to study the role of ventromedial prefrontal cortex in the regulation of threat- and reward-elicited responsesAngela C. Roberts and Hannah F. ClarkePNAS December 26, 2019 116 (52) 26297-26304; first published December 23, 2019. https://doi.org/10.1073/pnas.1902288116
- You have accessThe contribution of nonhuman primate research to the understanding of emotion and cognition and its clinical relevanceSilvia Bernardi and C. Daniel SalzmanPNAS December 26, 2019 116 (52) 26305-26312; first published December 23, 2019. https://doi.org/10.1073/pnas.1902293116
- You have accessMultiple neuronal circuits for variable object–action choices based on short- and long-term memoriesOkihide Hikosaka, Masaharu Yasuda, Kae Nakamura, Masaki Isoda, Hyoung F. Kim, Yasuo Terao, Hidetoshi Amita, and Kazutaka MaedaPNAS December 26, 2019 116 (52) 26313-26320; first published December 23, 2019. https://doi.org/10.1073/pnas.1902283116
- You have accessThe mind–body problem: Circuits that link the cerebral cortex to the adrenal medullaRichard P. Dum, David J. Levinthal, and Peter L. StrickPNAS December 26, 2019 116 (52) 26321-26328; first published December 23, 2019. https://doi.org/10.1073/pnas.1902297116
- Open AccessPrecise timing is ubiquitous, consistent, and coordinated across a comprehensive, spike-resolved flight motor programJoy Putney, Rachel Conn, and Simon SponbergPNAS December 26, 2019 116 (52) 26951-26960; first published December 16, 2019. https://doi.org/10.1073/pnas.1907513116
- Open AccessIndividual structural features constrain the mouse functional connectomeFrancesca Melozzi, Eyal Bergmann, Julie A. Harris, Itamar Kahn, Viktor Jirsa, and Christophe BernardPNAS December 26, 2019 116 (52) 26961-26969; first published December 11, 2019. https://doi.org/10.1073/pnas.1906694116
- You have accessVentral hippocampus interacts with prelimbic cortex during inhibition of threat response via learned safety in both mice and humansHeidi C. Meyer, Paola Odriozola, Emily M. Cohodes, Jeffrey D. Mandell, Anfei Li, Ruirong Yang, Baila S. Hall, Jason T. Haberman, Sadie J. Zacharek, Conor Liston, Francis S. Lee, and Dylan G. GeePNAS December 26, 2019 116 (52) 26970-26979; first published December 10, 2019. https://doi.org/10.1073/pnas.1910481116
- Open AccessMolecular profiling of single neurons of known identity in two ganglia from the crab Cancer borealisAdam J. Northcutt, Daniel R. Kick, Adriane G. Otopalik, Benjamin M. Goetz, Rayna M. Harris, Joseph M. Santin, Hans A. Hofmann, Eve Marder, and David J. SchulzPNAS December 26, 2019 116 (52) 26980-26990; first published December 5, 2019. https://doi.org/10.1073/pnas.1911413116
- You have accessThe network architecture of rat intrinsic interbrain (diencephalic) macroconnectionsLarry W. Swanson, Olaf Sporns, and Joel D. HahnPNAS December 26, 2019 116 (52) 26991-27000; first published December 5, 2019. https://doi.org/10.1073/pnas.1915446116
- You have accessSources of off-target expression from recombinase-dependent AAV vectors and mitigation with cross-over insensitive ATG-out vectorsKyle B. Fischer, Hannah K. Collins, and Edward M. CallawayPNAS December 26, 2019 116 (52) 27001-27010; first published December 16, 2019. https://doi.org/10.1073/pnas.1915974116
- You have accessSynaptic control of spinal GRPR+ neurons by local and long-range inhibitory inputsMing-Zhe Liu, Xiao-Jun Chen, Tong-Yu Liang, Qing Li, Meng Wang, Xin-Yan Zhang, Yu-Zhuo Li, Qiang Sun, and Yan-Gang SunPNAS December 26, 2019 116 (52) 27011-27017; first published December 5, 2019. https://doi.org/10.1073/pnas.1905658116
- You have accessSecond-order cues to figure motion enable object detection during prey capture by praying mantisesVivek Nityananda, James O’Keeffe, Diana Umeton, Adam Simmons, and Jenny C. A. ReadPNAS December 26, 2019 116 (52) 27018-27027; first published December 9, 2019. https://doi.org/10.1073/pnas.1912310116
- You have access5-HT2A receptor activation normalizes stress-induced dysregulation of GABAergic signaling in the ventral tegmental areaBlake A. Kimmey, Alexey Ostroumov, and John A. DaniPNAS December 26, 2019 116 (52) 27028-27034; first published December 5, 2019. https://doi.org/10.1073/pnas.1911446116
- Open AccessPosition–theta-phase model of hippocampal place cell activity applied to quantification of running speed modulation of firing rateKathryn McClain, David Tingley, David J. Heeger, and György BuzsákiPNAS December 26, 2019 116 (52) 27035-27042; first published December 16, 2019. https://doi.org/10.1073/pnas.1912792116
- You have accessPhotoreceptor disc membranes are formed through an Arp2/3-dependent lamellipodium-like mechanismWilliam J. Spencer, Tylor R. Lewis, Sebastien Phan, Martha A. Cady, Ekaterina O. Serebrovskaya, Nicholas F. Schneider, Keun-Young Kim, Lisa A. Cameron, Nikolai P. Skiba, Mark H. Ellisman, and Vadim Y. ArshavskyPNAS December 26, 2019 116 (52) 27043-27052; first published December 16, 2019. https://doi.org/10.1073/pnas.1913518117
- Open AccessA systematic capsid evolution approach performed in vivo for the design of AAV vectors with tailored properties and tropismMarcus Davidsson, Gang Wang, Patrick Aldrin-Kirk, Tiago Cardoso, Sara Nolbrant, Morgan Hartnor, Janitha Mudannayake, Malin Parmar, and Tomas BjörklundPNAS December 26, 2019 116 (52) 27053-27062; first published December 9, 2019. https://doi.org/10.1073/pnas.1910061116
- You have accessPerineuronal nets protect long-term memory by limiting activity-dependent inhibition from parvalbumin interneuronsWei Shi, Xiangbo Wei, Xiaofei Wang, Shuwen Du, Weixuan Liu, Jian Song, and Yun WangPNAS December 26, 2019 116 (52) 27063-27073; first published December 16, 2019. https://doi.org/10.1073/pnas.1902680116
- You have accessEvoked potentials as a biomarker of remyelinationMoones Heidari, Abigail B. Radcliff, Gillian J. McLellan, James N. Ver Hoeve, Kore Chan, Julie A. Kiland, Nicholas S. Keuler, Benjamin K. August, Dylan Sebo, Aaron S. Field, and Ian D. DuncanPNAS December 26, 2019 116 (52) 27074-27083; first published December 16, 2019. https://doi.org/10.1073/pnas.1906358116
- You have accessDescending projections from the substantia nigra pars reticulata differentially control seizuresEvan Wicker, Veronica C. Beck, Colin Kulick-Soper, Catherine V. Kulick-Soper, Safwan K. Hyder, Carolina Campos-Rodriguez, Tahiyana Khan, Prosper N’Gouemo, and Patrick A. ForcelliPNAS December 26, 2019 116 (52) 27084-27094; first published December 16, 2019. https://doi.org/10.1073/pnas.1908176117
Physiology
- You have accessSUMO1 modification of PKD2 channels regulates arterial contractilityRaquibul Hasan, M. Dennis Leo, Padmapriya Muralidharan, Alejandro Mata-Daboin, Wen Yin, Simon Bulley, Carlos Fernandez-Peña, Charles E. MacKay, and Jonathan H. JaggarPNAS December 26, 2019 116 (52) 27095-27104; first published December 10, 2019. https://doi.org/10.1073/pnas.1917264116
Plant Biology
- Open AccessA noncanonical vacuolar sugar transferase required for biosynthesis of antimicrobial defense compounds in oatAnastasia Orme, Thomas Louveau, Michael J. Stephenson, Ingo Appelhagen, Rachel Melton, Jitender Cheema, Yan Li, Qiang Zhao, Lei Zhang, Danlin Fan, Qilin Tian, Robert J. Vickerstaff, Tim Langdon, Bin Han, and Anne OsbournPNAS December 26, 2019 116 (52) 27105-27114; first published December 5, 2019. https://doi.org/10.1073/pnas.1914652116
- You have accessThe γ-tubulin complex protein GCP6 is crucial for spindle morphogenesis but not essential for microtubule reorganization in ArabidopsisHuiying Miao, Rongfang Guo, Junlin Chen, Qiaomei Wang, Yuh-Ru Julie Lee, and Bo LiuPNAS December 26, 2019 116 (52) 27115-27123; first published December 9, 2019. https://doi.org/10.1073/pnas.1912240116
- Open AccessTranscriptomic analysis of field-droughted sorghum from seedling to maturity reveals biotic and metabolic responsesNelle Varoquaux, Benjamin Cole, Cheng Gao, Grady Pierroz, Christopher R. Baker, Dhruv Patel, Mary Madera, Tim Jeffers, Joy Hollingsworth, Julie Sievert, Yuko Yoshinaga, Judith A. Owiti, Vasanth R. Singan, Stephanie DeGraaf, Ling Xu, Matthew J. Blow, Maria J. Harrison, Axel Visel, Christer Jansson, Krishna K. Niyogi, Robert Hutmacher, Devin Coleman-Derr, Ronan C. O’Malley, John W. Taylor, Jeffery Dahlberg, John P. Vogel, Peggy G. Lemaux, and Elizabeth PurdomPNAS December 26, 2019 116 (52) 27124-27132; first published December 5, 2019. https://doi.org/10.1073/pnas.1907500116
- You have accessCryptochrome 2 competes with COP1 substrates to repress COP1 ubiquitin ligase activity during Arabidopsis photomorphogenesisJathish Ponnu, Tabea Riedel, Eva Penner, Andrea Schrader, and Ute HoeckerPNAS December 26, 2019 116 (52) 27133-27141; first published December 10, 2019. https://doi.org/10.1073/pnas.1909181116
Population Biology
- Open AccessVirus–virus interactions impact the population dynamics of influenza and the common coldSema Nickbakhsh, Colette Mair, Louise Matthews, Richard Reeve, Paul C. D. Johnson, Fiona Thorburn, Beatrix von Wissmann, Arlene Reynolds, James McMenamin, Rory N. Gunson, and Pablo R. MurciaPNAS December 26, 2019 116 (52) 27142-27150; first published December 16, 2019. https://doi.org/10.1073/pnas.1911083116
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Sustainability Science
- Open AccessSixteen years of social and ecological dynamics reveal challenges and opportunities for adaptive management in sustaining the commonsJ. E. Cinner, J. D. Lau, A. G. Bauman, D. A. Feary, F. A. Januchowski-Hartley, C. A. Rojas, M. L. Barnes, B. J. Bergseth, E. Shum, R. Lahari, J. Ben, and N. A. J. GrahamPNAS December 26, 2019 116 (52) 26474-26483; first published December 16, 2019. https://doi.org/10.1073/pnas.1914812116
Systems Biology
- You have accessDeep learning for inferring gene relationships from single-cell expression dataYe Yuan and Ziv Bar-JosephPNAS December 26, 2019 116 (52) 27151-27158; first published December 10, 2019. https://doi.org/10.1073/pnas.1911536116
Corrections
- You have accessCorrection for Kumra et al., Fibulin-4 exerts a dual role in LTBP-4L–mediated matrix assembly and functionPNAS December 26, 2019 116 (52) 27159; first published December 16, 2019. https://doi.org/10.1073/pnas.1920843117
- You have accessCorrection for Fan et al., Abscisic acid regulation of guard-cell K+ and anion channels in Gβ- and RGS-deficient Arabidopsis linesPNAS December 26, 2019 116 (52) 27160-27161; first published December 23, 2019. https://doi.org/10.1073/pnas.1920065116
- You have accessCorrection for de la Cuesta et al., Oil and aid revenue produce equal demands for accountability as taxes in Ghana and UgandaPNAS December 26, 2019 116 (52) 27162; first published December 16, 2019. https://doi.org/10.1073/pnas.1920067116
- You have accessCorrection for Duckworth et al., Cognitive and noncognitive predictors of successPNAS December 26, 2019 116 (52) 27163; first published December 16, 2019. https://doi.org/10.1073/pnas.1920625117
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