Ventral hippocampus interacts with prelimbic cortex during inhibition of threat response via learned safety in both mice and humans

^aDepartment of Psychiatry, Weill Cornell Medicine, New York, NY 10065;
^bDepartment of Psychology, Yale University, New Haven, CT 06511;
^cProgram in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06511;
^dDepartment of Psychology, Brain Research Institute, University of California, Los Angeles, CA 90095;
^eSackler Institute for Developmental Psychobiology, Weill Cornell Medicine, New York, NY 10065;
^fFeil Family Brain & Mind Research Institute, Weill Cornell Medicine, New York, NY 10065

Edited by Bruce S. McEwen, Rockefeller University, New York, NY, and approved November 8, 2019 (received for review June 25, 2019)

Footnotes

↵¹H.C.M. and P.O. contributed equally to this work.
↵²F.S.L. and D.G.G. contributed equally to this work.
↵³To whom correspondence may be addressed. Email: fslee{at}med.cornell.edu or dylan.gee{at}yale.edu.

Author contributions: H.C.M., P.O., E.M.C., J.T.H., F.S.L., and D.G.G. designed research; H.C.M., P.O., E.M.C., R.Y., J.T.H., and S.J.Z. performed research; P.O., J.D.M., B.S.H., S.J.Z., and C.L. contributed new reagents/analytic tools; H.C.M., P.O., A.L., B.S.H., S.J.Z., C.L., and D.G.G. analyzed data; and H.C.M., P.O., E.M.C., F.S.L., and D.G.G. wrote the paper.
The authors declare no competing interest.
This article is a PNAS Direct Submission.
Data deposition: Data used for these studies have been deposited in the Open Science Framework Repository (https://osf.io/nqryd/).
This article contains supporting information online at https://www.pnas.org/lookup/suppl/doi:10.1073/pnas.1910481116/-/DCSupplemental.