Antagonists of growth hormone-releasing hormone (GHRH) inhibit the growth of human malignant pleural mesothelioma

Tania Villanova, Iacopo Gesmundo, Valentina Audrito, Nicoletta Vitale, Francesca Silvagno, Chiara Musuraca, Luisella Righi, Roberta Libener, Chiara Riganti, Paolo Bironzo, Silvia Deaglio, Mauro Papotti, Renzhi Cai, Wei Sha, Ezio Ghigo, Andrew V. Schally, and Riccarda Granata
PNAS February 5, 2019 116 (6) 2226-2231; published ahead of print February 5, 2019 https://doi.org/10.1073/pnas.1818865116

  1. Contributed by Andrew V. Schally, December 11, 2018 (sent for review November 6, 2018; reviewed by Justo P. Castano and Hippokratis Kiaris)

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Article Information

vol. 116 no. 6 2226-2231
DOI: 
https://doi.org/10.1073/pnas.1818865116
PubMed: 
30659154
Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published February 5, 2019.
Copyright & Usage: 
Copyright © 2019 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

Author Information

  1. Tania Villanovaa,1,
  2. Iacopo Gesmundoa,1,
  3. Valentina Audritob,c,
  4. Nicoletta Vitaled,
  5. Francesca Silvagnoe,
  6. Chiara Musuracae,
  7. Luisella Righif,
  8. Roberta Libenerg,
  9. Chiara Rigantie,
  10. Paolo Bironzof,
  11. Silvia Deagliob,c,
  12. Mauro Papottie,
  13. Renzhi Caih,i,
  14. Wei Shah,i,
  15. Ezio Ghigoa,
  16. Andrew V. Schallyh,i,j,k,l,2, and
  17. Riccarda Granataa,2
  1. aDivision of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, 10126 Turin, Italy;
  2. bDepartment of Medical Sciences, University of Turin, 10126 Turin, Italy;
  3. cItalian Institute for Genomic Medicine, 10126 Turin, Italy;
  4. dDepartment of Molecular Biotechnology and Health Sciences, University of Turin, 10126 Turin, Italy;
  5. eDepartment of Oncology, University of Turin, 10126 Turin, Italy;
  6. fDepartment of Oncology, San Luigi Gonzaga Hospital, University of Turin, 10043 Orbassano, Italy;
  7. gPathology Unit, SS. Antonio e Biagio General Hospital, 15121 Alessandria, Italy;
  8. hDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136;
  9. iEndocrine, Polypeptide and Cancer Institute, Veterans Affairs Medical Center, Miami, FL 33125;
  10. jSylvester Comprehensive Cancer Center, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136;
  11. kDivision of Hematology/Oncology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136;
  12. lDepartment of Pathology, Miller School of Medicine, University of Miami, Miami, FL 33136

  1. Contributed by Andrew V. Schally, December 11, 2018 (sent for review November 6, 2018; reviewed by Justo P. Castano and Hippokratis Kiaris)

Footnotes

  • ↵1T.V. and I.G. contributed equally to this work.

  • ↵2To whom correspondence may be addressed. Email: andrew.schally{at}va.gov or riccarda.granata{at}unito.it.

  • Author contributions: R.G. designed research; T.V., I.G., V.A., N.V., F.S., C.M., and L.R. performed research; R.L., C.R., P.B., M.P., R.C., W.S., and A.V.S. contributed new reagents/analytic tools; I.G., V.A., C.R., S.D., M.P., E.G., A.V.S., and R.G. analyzed data; and R.G. wrote the paper.

  • Reviewers: J.P.C., University of Cordoba; and H.K., University of South Carolina.

  • Conflict of interest statement: A.V.S. and R.C. are listed as co-inventors on the patent for GHRH agonists, assigned to the University of Miami, Miami, FL, and the Veterans Affairs Medical Center, Miami, FL. The remaining authors declare no conflict of interest.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1818865116/-/DCSupplemental.

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Antagonists of growth hormone-releasing hormone (GHRH) inhibit the growth of human malignant pleural mesothelioma
Tania Villanova, Iacopo Gesmundo, Valentina Audrito, Nicoletta Vitale, Francesca Silvagno, Chiara Musuraca, Luisella Righi, Roberta Libener, Chiara Riganti, Paolo Bironzo, Silvia Deaglio, Mauro Papotti, Renzhi Cai, Wei Sha, Ezio Ghigo, Andrew V. Schally, Riccarda Granata
Proceedings of the National Academy of Sciences Feb 2019, 116 (6) 2226-2231; DOI: 10.1073/pnas.1818865116
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