Skip to main content
  • Submit
  • About
    • Editorial Board
    • PNAS Staff
    • FAQ
    • Rights and Permissions
    • Site Map
  • Contact
  • Journal Club
  • Subscribe
    • Subscription Rates
    • Subscriptions FAQ
    • Open Access
    • Recommend PNAS to Your Librarian
  • Log in
  • My Cart

Main menu

  • Home
  • Articles
    • Current
    • Latest Articles
    • Special Features
    • Colloquia
    • Collected Articles
    • PNAS Classics
    • Archive
  • Front Matter
  • News
    • For the Press
    • Highlights from Latest Articles
    • PNAS in the News
  • Podcasts
  • Authors
    • Information for Authors
    • Purpose and Scope
    • Editorial and Journal Policies
    • Submission Procedures
    • For Reviewers
    • Author FAQ
  • Submit
  • About
    • Editorial Board
    • PNAS Staff
    • FAQ
    • Rights and Permissions
    • Site Map
  • Contact
  • Journal Club
  • Subscribe
    • Subscription Rates
    • Subscriptions FAQ
    • Open Access
    • Recommend PNAS to Your Librarian

User menu

  • Log in
  • My Cart

Search

  • Advanced search
Home
Home

Advanced Search

  • Home
  • Articles
    • Current
    • Latest Articles
    • Special Features
    • Colloquia
    • Collected Articles
    • PNAS Classics
    • Archive
  • Front Matter
  • News
    • For the Press
    • Highlights from Latest Articles
    • PNAS in the News
  • Podcasts
  • Authors
    • Information for Authors
    • Purpose and Scope
    • Editorial and Journal Policies
    • Submission Procedures
    • For Reviewers
    • Author FAQ

New Research In

Physical Sciences

Featured Portals

  • Physics
  • Chemistry
  • Sustainability Science

Articles by Topic

  • Applied Mathematics
  • Applied Physical Sciences
  • Astronomy
  • Computer Sciences
  • Earth, Atmospheric, and Planetary Sciences
  • Engineering
  • Environmental Sciences
  • Mathematics
  • Statistics

Social Sciences

Featured Portals

  • Anthropology
  • Sustainability Science

Articles by Topic

  • Economic Sciences
  • Environmental Sciences
  • Political Sciences
  • Psychological and Cognitive Sciences
  • Social Sciences

Biological Sciences

Featured Portals

  • Sustainability Science

Articles by Topic

  • Agricultural Sciences
  • Anthropology
  • Applied Biological Sciences
  • Biochemistry
  • Biophysics and Computational Biology
  • Cell Biology
  • Developmental Biology
  • Ecology
  • Environmental Sciences
  • Evolution
  • Genetics
  • Immunology and Inflammation
  • Medical Sciences
  • Microbiology
  • Neuroscience
  • Pharmacology
  • Physiology
  • Plant Biology
  • Population Biology
  • Psychological and Cognitive Sciences
  • Sustainability Science
  • Systems Biology

Fluorescent reconstitution on deposition of PM2.5 in lung and extrapulmonary organs

Donghai Li, Yongjian Li, Guiling Li, Yu Zhang, Jiang Li, and Haosheng Chen
PNAS February 12, 2019 116 (7) 2488-2493; published ahead of print February 12, 2019 https://doi.org/10.1073/pnas.1818134116
Donghai Li
aState Key Laboratory of Tribology, Tsinghua University, 100084 Beijing, China;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Donghai Li
Yongjian Li
aState Key Laboratory of Tribology, Tsinghua University, 100084 Beijing, China;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Guiling Li
bSchool of Pharmaceutical Sciences, Tsinghua University, 100084 Beijing, China;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yu Zhang
cSchool of Medicine, Tsinghua University, 100084 Beijing, China;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jiang Li
dSchool of Mechanical Engineering, University of Science and Technology, 100083 Beijing, China
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jiang Li
Haosheng Chen
aState Key Laboratory of Tribology, Tsinghua University, 100084 Beijing, China;
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Haosheng Chen
  • For correspondence: chenhs@tsinghua.edu.cn
  1. Edited by David A. Weitz, Harvard University, Cambridge, MA, and approved December 24, 2018 (received for review October 23, 2018)

  • Article
  • Figures & SI
  • Info & Metrics
  • PDF
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Significance

It is always a challenge to see the deposition of single PM2.5 particles, the harmful inhalable aerosols in the polluted air, in alveolar region, and their invasion to the extrapulmonary organs. The dynamic deposition process and the nonuniform deposition pattern of PM2.5 in the alveolar region are revealed using a fluorescent imaging method with high temporal and spatial resolutions. This observation technology would also bring insight in the study of the public health in air pollution and lung administration.

Abstract

The deposition of PM2.5 (fine particulate matter in air with diameter smaller than 2.5 μm) in lungs is harmful to human health. However, real-time observation on the deposition of particles in the acinar area of the lung is still a challenge in experiments. Here, a fluorescent imaging method is developed to visualize the deposition process with a high temporal and spatial resolution. The observations reveal that the deposition pattern is nonuniform, and the maximum deposition rate in the acinar area differs significantly from the prediction of the widely used average deposition model. The method is also used to find single particles in the kidney and liver, though such particles are commonly believed to be too large to enter the extrapulmonary organs.

  • PM2.5
  • lung
  • air pollution
  • particle deposition
  • extrapulmonary organs

Footnotes

  • ↵1To whom correspondence should be addressed. Email: chenhs{at}tsinghua.edu.cn.
  • Author contributions: J.L. and H.C. designed research; D.L. performed research; H.C. contributed new reagents/analytic tools; Y.L., G.L., Y.Z., and H.C. analyzed data; and J.L. and H.C. wrote the paper.

  • The authors declare no conflict of interest.

  • This article is a PNAS Direct Submission.

  • This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1818134116/-/DCSupplemental.

Published under the PNAS license.

View Full Text

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.

Subscribers, for more details, please visit our Subscriptions FAQ.

Please click here to log into the PNAS submission website.

PreviousNext
Back to top
Article Alerts
Email Article

Thank you for your interest in spreading the word on PNAS.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Fluorescent reconstitution on deposition of PM2.5 in lung and extrapulmonary organs
(Your Name) has sent you a message from PNAS
(Your Name) thought you would like to see the PNAS web site.
Citation Tools
Fluorescent reconstitution on deposition of PM2.5 in lung and extrapulmonary organs
Donghai Li, Yongjian Li, Guiling Li, Yu Zhang, Jiang Li, Haosheng Chen
Proceedings of the National Academy of Sciences Feb 2019, 116 (7) 2488-2493; DOI: 10.1073/pnas.1818134116

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Request Permissions
Share
Fluorescent reconstitution on deposition of PM2.5 in lung and extrapulmonary organs
Donghai Li, Yongjian Li, Guiling Li, Yu Zhang, Jiang Li, Haosheng Chen
Proceedings of the National Academy of Sciences Feb 2019, 116 (7) 2488-2493; DOI: 10.1073/pnas.1818134116
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Mendeley logo Mendeley
Proceedings of the National Academy of Sciences: 116 (7)
Current Issue

Submit

Sign up for Article Alerts

Jump to section

  • Article
    • Abstract
    • Results
    • Materials and Methods
    • Conclusion
    • Acknowledgments
    • Footnotes
    • References
  • Figures & SI
  • Info & Metrics
  • PDF

You May Also be Interested in

Several aspects of the proposal, which aims to expand open access, require serious discussion and, in some cases, a rethink.
Opinion: “Plan S” falls short for society publishers—and for the researchers they serve
Several aspects of the proposal, which aims to expand open access, require serious discussion and, in some cases, a rethink.
Image credit: Dave Cutler (artist).
Several large or long-lived animals seem strangely resistant to developing cancer. Elucidating the reasons why could lead to promising cancer-fighting strategies in humans.
Core Concept: Solving Peto’s Paradox to better understand cancer
Several large or long-lived animals seem strangely resistant to developing cancer. Elucidating the reasons why could lead to promising cancer-fighting strategies in humans.
Image credit: Shutterstock.com/ronnybas frimages.
Featured Profile
PNAS Profile of NAS member and biochemist Hao Wu
 Nonmonogamous strawberry poison frog (Oophaga pumilio).  Image courtesy of Yusan Yang (University of Pittsburgh, Pittsburgh).
Putative signature of monogamy
A study suggests a putative gene-expression hallmark common to monogamous male vertebrates of some species, namely cichlid fishes, dendrobatid frogs, passeroid songbirds, common voles, and deer mice, and identifies 24 candidate genes potentially associated with monogamy.
Image courtesy of Yusan Yang (University of Pittsburgh, Pittsburgh).
Active lifestyles. Image courtesy of Pixabay/MabelAmber.
Meaningful life tied to healthy aging
Physical and social well-being in old age are linked to self-assessments of life worth, and a spectrum of behavioral, economic, health, and social variables may influence whether aging individuals believe they are leading meaningful lives.
Image courtesy of Pixabay/MabelAmber.

More Articles of This Classification

Physical Sciences

  • Deep elastic strain engineering of bandgap through machine learning
  • Single-molecule excitation–emission spectroscopy
  • Microscopic description of acid–base equilibrium
Show more

Environmental Sciences

  • Stratification of reactivity determines nitrate removal in groundwater
  • In utero ultrafine particulate matter exposure causes offspring pulmonary immunosuppression
Show more

Biological Sciences

  • Structural basis for activity of TRIC counter-ion channels in calcium release
  • PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin
  • Altered neural odometry in the vertical dimension
Show more

Applied Biological Sciences

  • Dynamically stiffened matrix promotes malignant transformation of mammary epithelial cells via collective mechanical signaling
  • Chronic and acute stress monitoring by electrophysiological signals from adrenal gland
Show more

Related Content

  • No related articles found.
  • Scopus
  • PubMed
  • Google Scholar

Cited by...

  • No citing articles found.
  • Google Scholar

Similar Articles

Site Logo
Powered by HighWire
  • Submit Manuscript
  • Twitter
  • Facebook
  • RSS Feeds
  • Email Alerts

Articles

  • Current Issue
  • Latest Articles
  • Archive

PNAS Portals

  • Classics
  • Front Matter
  • Teaching Resources
  • Anthropology
  • Chemistry
  • Physics
  • Sustainability Science

Information

  • Authors
  • Editorial Board
  • Reviewers
  • Press
  • Site Map

Feedback    Privacy/Legal

Copyright © 2019 National Academy of Sciences. Online ISSN 1091-6490