Table of Contents

Biological Sciences

• Agricultural Sciences

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    Smallholder farmers and contract farming in developing countries

    Eva-Marie Meemken and Marc F. Bellemare

    PNAS January 7, 2020 117 (1) 259-264; first published December 13, 2019. https://doi.org/10.1073/pnas.1909501116
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    An R2R3 MYB transcription factor confers brown planthopper resistance by regulating the phenylalanine ammonia-lyase pathway in rice

    Jun He, Yuqiang Liu, Dingyang Yuan, Meijuan Duan, Yanling Liu, Zijie Shen, Chunyan Yang, Zeyu Qiu, Daoming Liu, Peizheng Wen, Jie Huang, Dejia Fan, Shizhuo Xiao, Yeyun Xin, Xianian Chen, Ling Jiang, Haiyang Wang, Longping Yuan, and Jianmin Wan

    PNAS January 7, 2020 117 (1) 271-277; first published December 17, 2019. https://doi.org/10.1073/pnas.1902771116

• Anthropology

  • Open Access

    Insights into the lower torso in late Miocene hominoid Oreopithecus bambolii

    Ashley S. Hammond, Lorenzo Rook, Alisha D. Anaya, Elisabetta Cioppi, Loïc Costeur, Salvador Moyà-Solà, and Sergio Almécija

    PNAS January 7, 2020 117 (1) 278-284; first published December 23, 2019. https://doi.org/10.1073/pnas.1911896116

• Applied Biological Sciences

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    High-density chemical cross-linking for modeling protein interactions

    Julian Mintseris and Steven P. Gygi

    PNAS January 7, 2020 117 (1) 93-102; first published December 17, 2019. https://doi.org/10.1073/pnas.1902931116
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    Ultrasmall silica nanoparticles directly ligate the T cell receptor complex

    Bradley Vis, Rachel E. Hewitt, Tom P. Monie, Camilla Fairbairn, Suzanne D. Turner, Stephen D. Kinrade, and Jonathan J. Powell

    PNAS January 7, 2020 117 (1) 285-291; first published December 23, 2019. https://doi.org/10.1073/pnas.1911360117
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    Kappa-on-Heavy (KoH) bodies are a distinct class of fully-human antibody-like therapeutic agents with antigen-binding properties

    Lynn E. Macdonald, Karoline A. Meagher, Matthew C. Franklin, Natasha Levenkova, Johanna Hansen, Ashok T. Badithe, Maggie Zhong, Pamela Krueger, Ashique Rafique, Naxin Tu, James Shevchuk, Saurabh Wadhwa, George Ehrlich, Joannie Bautista, Craig Grant, Lakeisha Esau, William T. Poueymirou, Wojtek Auerbach, Lori Morton, Robert Babb, Gang Chen, Tammy Huang, Douglas MacDonald, Kenneth Graham, Cagan Gurer, Vera A. Voronina, John R. McWhirter, Chunguang Guo, George D. Yancopoulos, and Andrew J. Murphy

    PNAS January 7, 2020 117 (1) 292-299; first published December 26, 2019. https://doi.org/10.1073/pnas.1901734117

• Biochemistry

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    Light-driven carbon−carbon bond formation via CO₂ reduction catalyzed by complexes of CdS nanorods and a 2-oxoacid oxidoreductase

    Hayden Hamby, Bin Li, Katherine E. Shinopoulos, Helena R. Keller, Sean J. Elliott, and Gordana Dukovic

    PNAS January 7, 2020 117 (1) 135-140; first published December 18, 2019. https://doi.org/10.1073/pnas.1903948116
  • Open Access

    Photoreversible interconversion of a phytochrome photosensory module in the crystalline state

    E. Sethe Burgie, Jonathan A. Clinger, Mitchell D. Miller, Aaron S. Brewster, Pierre Aller, Agata Butryn, Franklin D. Fuller, Sheraz Gul, Iris D. Young, Cindy C. Pham, In-Sik Kim, Asmit Bhowmick, Lee J. O’Riordan, Kyle D. Sutherlin, Joshua V. Heinemann, Alexander Batyuk, Roberto Alonso-Mori, Mark S. Hunter, Jason E. Koglin, Junko Yano, Vittal K. Yachandra, Nicholas K. Sauter, Aina E. Cohen, Jan Kern, Allen M. Orville, George N. Phillips Jr, and Richard D. Vierstra

    PNAS January 7, 2020 117 (1) 300-307; first published December 18, 2019. https://doi.org/10.1073/pnas.1912041116
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    In situ self-assembling Au-DNA complexes for targeted cancer bioimaging and inhibition

    Maonan Wang, Yun Chen, Weijuan Cai, Huan Feng, Tianyu Du, Weiwei Liu, Hui Jiang, Alberto Pasquarelli, Yossi Weizmann, and Xuemei Wang

    PNAS January 7, 2020 117 (1) 308-316; first published December 16, 2019. https://doi.org/10.1073/pnas.1915512116
  • Open Access

    Molecular mechanism of leukocidin GH–integrin CD11b/CD18 recognition and species specificity

    Nikolina Trstenjak, Dalibor Milić, Melissa A. Graewert, Harald Rouha, Dmitri Svergun, Kristina Djinović-Carugo, Eszter Nagy, and Adriana Badarau

    PNAS January 7, 2020 117 (1) 317-327; first published December 18, 2019. https://doi.org/10.1073/pnas.1913690116
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    Reversible phosphorylation of Rpn1 regulates 26S proteasome assembly and function

    Xiaoyan Liu, Weidi Xiao, Yanan Zhang, Sandra E. Wiley, Tao Zuo, Yingying Zheng, Natalie Chen, Lu Chen, Xiaorong Wang, Yawen Zheng, Lan Huang, Shixian Lin, Anne N. Murphy, Jack E. Dixon, Ping Xu, and Xing Guo

    PNAS January 7, 2020 117 (1) 328-336; first published December 16, 2019. https://doi.org/10.1073/pnas.1912531117
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    Structure, function, and evolution of Gga-AvBD11, the archetype of the structural avian-double-β-defensin family

    Nicolas Guyot, Hervé Meudal, Sascha Trapp, Sophie Iochmann, Anne Silvestre, Guillaume Jousset, Valérie Labas, Pascale Reverdiau, Karine Loth, Virginie Hervé, Vincent Aucagne, Agnès F. Delmas, Sophie Rehault-Godbert, and Céline Landon

    PNAS January 7, 2020 117 (1) 337-345; first published December 23, 2019. https://doi.org/10.1073/pnas.1912941117
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    Analysis of allosteric communication in a multienzyme complex by ancestral sequence reconstruction

    Michael Schupfner, Kristina Straub, Florian Busch, Rainer Merkl, and Reinhard Sterner

    PNAS January 7, 2020 117 (1) 346-354; first published December 23, 2019. https://doi.org/10.1073/pnas.1912132117
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    Uncovering the functional residues of Arabidopsis isoprenoid biosynthesis enzyme HDS

    Jin-Zheng Wang, Yongxing Lei, Yanmei Xiao, Xiang He, Jiubo Liang, Jishan Jiang, Shangzhi Dong, Haiyan Ke, Patricia Leon, Philipp Zerbe, Youli Xiao, and Katayoon Dehesh

    PNAS January 7, 2020 117 (1) 355-361; first published December 26, 2019. https://doi.org/10.1073/pnas.1916434117
  • Open Access

    An inhibitor of complement C5 provides structural insights into activation

    Martin P. Reichhardt, Steven Johnson, Terence Tang, Thomas Morgan, Nchimunya Tebeka, Niko Popitsch, Justin C. Deme, Matthijs M. Jore, and Susan M. Lea

    PNAS January 7, 2020 117 (1) 362-370; first published December 23, 2019. https://doi.org/10.1073/pnas.1909973116
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    DeepRiPP integrates multiomics data to automate discovery of novel ribosomally synthesized natural products

    Nishanth J. Merwin, Walaa K. Mousa, Chris A. Dejong, Michael A. Skinnider, Michael J. Cannon, Haoxin Li, Keshav Dial, Mathusan Gunabalasingam, Chad Johnston, and Nathan A. Magarvey

    PNAS January 7, 2020 117 (1) 371-380; first published December 23, 2019. https://doi.org/10.1073/pnas.1901493116
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    Insights into the mechanism and regulation of the CbbQO-type Rubisco activase, a MoxR AAA+ ATPase

    Yi-Chin Candace Tsai, Fuzhou Ye, Lynette Liew, Di Liu, Shashi Bhushan, Yong-Gui Gao, and Oliver Mueller-Cajar

    PNAS January 7, 2020 117 (1) 381-387; first published December 17, 2019. https://doi.org/10.1073/pnas.1911123117

• Biophysics and Computational Biology

  • Open Access

    Accurate and rapid background estimation in single-molecule localization microscopy using the deep neural network BGnet

    Leonhard Möckl, Anish R. Roy, Petar N. Petrov, and W. E. Moerner

    PNAS January 7, 2020 117 (1) 60-67; first published December 23, 2019. https://doi.org/10.1073/pnas.1916219117
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    Assessment of the manganese cluster’s oxidation state via photoactivation of photosystem II microcrystals

    Mun Hon Cheah, Miao Zhang, Dmitry Shevela, Fikret Mamedov, Athina Zouni, and Johannes Messinger

    PNAS January 7, 2020 117 (1) 141-145; first published December 17, 2019. https://doi.org/10.1073/pnas.1915879117
  • Open Access

    A bacterial surface layer protein exploits multistep crystallization for rapid self-assembly

    Jonathan Herrmann, Po-Nan Li, Fatemeh Jabbarpour, Anson C. K. Chan, Ivan Rajkovic, Tsutomu Matsui, Lucy Shapiro, John Smit, Thomas M. Weiss, Michael E. P. Murphy, and Soichi Wakatsuki

    PNAS January 7, 2020 117 (1) 388-394; first published December 17, 2019. https://doi.org/10.1073/pnas.1909798116
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    Two closed ATP- and ADP-dependent conformations in yeast Hsp90 chaperone detected by Mn(II) EPR spectroscopic techniques

    Angeliki Giannoulis, Akiva Feintuch, Yoav Barak, Hisham Mazal, Shira Albeck, Tamar Unger, Feng Yang, Xun-Cheng Su, and Daniella Goldfarb

    PNAS January 7, 2020 117 (1) 395-404; first published December 20, 2019. https://doi.org/10.1073/pnas.1916030116
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    Microsecond-timescale simulations suggest 5-HT–mediated preactivation of the 5-HT_3A serotonin receptor

    Nicholas B. Guros, Arvind Balijepalli, and Jeffery B. Klauda

    PNAS January 7, 2020 117 (1) 405-414; first published December 23, 2019. https://doi.org/10.1073/pnas.1908848117

• Cell Biology

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    B2 and ALU retrotransposons are self-cleaving ribozymes whose activity is enhanced by EZH2

    Alfredo J. Hernandez, Athanasios Zovoilis, Catherine Cifuentes-Rojas, Lu Han, Bojan Bujisic, and Jeannie T. Lee

    PNAS January 7, 2020 117 (1) 415-425; first published December 23, 2019. https://doi.org/10.1073/pnas.1917190117
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    Immunity against cancer cells may promote their proliferation and metastasis

    Chih-Wei Lin, Jia Xie, Ding Zhang, Kyung Ho Han, Geramie Grande, Nicholas C. Wu, Zhuo Yang, Kyungmoo Yea, and Richard A. Lerner

    PNAS January 7, 2020 117 (1) 426-431; first published December 23, 2019. https://doi.org/10.1073/pnas.1916833117
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    Actin protrusions push at apical junctions to maintain E-cadherin adhesion

    John Xiao He Li, Vivian W. Tang, and William M. Brieher

    PNAS January 7, 2020 117 (1) 432-438; first published December 23, 2019. https://doi.org/10.1073/pnas.1908654117
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    Regulation of INF2-mediated actin polymerization through site-specific lysine acetylation of actin itself

    Mu A, Tak Shun Fung, Lisa M. Francomacaro, Thao Huynh, Tommi Kotila, Zdenek Svindrych, and Henry N. Higgs

    PNAS January 7, 2020 117 (1) 439-447; first published December 23, 2019. https://doi.org/10.1073/pnas.1914072117
  • Open Access

    Enhanced expression of β cell Ca_V3.1 channels impairs insulin release and glucose homeostasis

    Jia Yu, Yue Shi, Kaixuan Zhao, Guang Yang, Lina Yu, Yuxin Li, Eva-Marie Andersson, Carina Ämmälä, Shao-Nian Yang, and Per-Olof Berggren

    PNAS January 7, 2020 117 (1) 448-453; first published December 23, 2019. https://doi.org/10.1073/pnas.1908691117
  • Open Access

    Identification of Pparγ-modulated miRNA hubs that target the fibrotic tumor microenvironment

    Ivana Winkler, Catrin Bitter, Sebastian Winkler, Dieter Weichenhan, Abhishek Thavamani, Jan G. Hengstler, Erawan Borkham-Kamphorst, Oliver Kohlbacher, Christoph Plass, Robert Geffers, Ralf Weiskirchen, and Alfred Nordheim

    PNAS January 7, 2020 117 (1) 454-463; first published December 23, 2019. https://doi.org/10.1073/pnas.1909145117

• Developmental Biology

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    An in vivo RNAi screen uncovers the role of AdoR signaling and adenosine deaminase in controlling intestinal stem cell activity

    Chiwei Xu, Brian Franklin, Hong-Wen Tang, Yannik Regimbald-Dumas, Yanhui Hu, Justine Ramos, Justin A. Bosch, Christians Villalta, Xi He, and Norbert Perrimon

    PNAS January 7, 2020 117 (1) 464-471; first published December 18, 2019. https://doi.org/10.1073/pnas.1900103117

• Ecology

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    Predator-informed looming stimulus experiments reveal how large filter feeding whales capture highly maneuverable forage fish

    • From the Cover

    David E. Cade, Nicholas Carey, Paolo Domenici, Jean Potvin, and Jeremy A. Goldbogen

    PNAS January 7, 2020 117 (1) 472-478; first published December 23, 2019. https://doi.org/10.1073/pnas.1911099116
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    Hidden similarities in the dynamics of a weakly synchronous marine metapopulation

    Tanya L. Rogers and Stephan B. Munch

    PNAS January 7, 2020 117 (1) 479-485; first published December 23, 2019. https://doi.org/10.1073/pnas.1910964117

• Environmental Sciences

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    Long-term effects of cultural filtering on megafauna species distributions across China

    Shuqing N. Teng, Chi Xu, Licheng Teng, and Jens-Christian Svenning

    PNAS January 7, 2020 117 (1) 486-493; first published December 23, 2019. https://doi.org/10.1073/pnas.1909896116

• Evolution

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    Mechanics unlocks the morphogenetic puzzle of interlocking bivalved shells

    • Cozzarelli Prize Winner

    Derek E. Moulton, Alain Goriely, and Régis Chirat

    PNAS January 7, 2020 117 (1) 43-51; first published December 16, 2019. https://doi.org/10.1073/pnas.1916520116
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    Genetically barcoded SIV reveals the emergence of escape mutations in multiple viral lineages during immune escape

    Taina T. Immonen, Celine Camus, Carolyn Reid, Christine M. Fennessey, Gregory Q. Del Prete, Miles P. Davenport, Jeffrey D. Lifson, and Brandon F. Keele

    PNAS January 7, 2020 117 (1) 494-502; first published December 16, 2019. https://doi.org/10.1073/pnas.1914967117
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    Dorsoventral decoupling of Hox gene expression underpins the diversification of molluscs

    Pin Huan, Qian Wang, Sujian Tan, and Baozhong Liu

    PNAS January 7, 2020 117 (1) 503-512; first published December 23, 2019. https://doi.org/10.1073/pnas.1907328117

• Genetics

  • Open Access

    CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer

    Sheng Rong Ng, William M. Rideout III, Elliot H. Akama-Garren, Arjun Bhutkar, Kim L. Mercer, Jason M. Schenkel, Roderick T. Bronson, and Tyler Jacks

    PNAS January 7, 2020 117 (1) 513-521; first published December 23, 2019. https://doi.org/10.1073/pnas.1821893117

• Immunology and Inflammation

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    Trans-endocytosis of intact IL-15Rα–IL-15 complex from presenting cells into NK cells favors signaling for proliferation

    Olga M. Anton, Mary E. Peterson, Michael J. Hollander, David W. Dorward, Gunjan Arora, Javier Traba, Sumati Rajagopalan, Erik L. Snapp, K. Christopher Garcia, Thomas A. Waldmann, and Eric O. Long

    PNAS January 7, 2020 117 (1) 522-531; first published December 23, 2019. https://doi.org/10.1073/pnas.1911678117
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    Determinants governing T cell receptor α/β-chain pairing in repertoire formation of identical twins

    Hidetaka Tanno, Timothy M. Gould, Jonathan R. McDaniel, Wenqiang Cao, Yuri Tanno, Russell E. Durrett, Daechan Park, Steven J. Cate, William H. Hildebrand, Cornelia L. Dekker, Lu Tian, Cornelia M. Weyand, George Georgiou, and Jörg J. Goronzy

    PNAS January 7, 2020 117 (1) 532-540; first published December 26, 2019. https://doi.org/10.1073/pnas.1915008117
  • Open Access

    Optimized antiangiogenic reprogramming of the tumor microenvironment potentiates CD40 immunotherapy

    Abhishek S. Kashyap, Martina Schmittnaegel, Nicolò Rigamonti, Daniela Pais-Ferreira, Philipp Mueller, Melanie Buchi, Chia-Huey Ooi, Matthias Kreuzaler, Petra Hirschmann, Alan Guichard, Natascha Rieder, Ruben Bill, Frank Herting, Yvonne Kienast, Stefan Dirnhofer, Christian Klein, Sabine Hoves, Carola H. Ries, Emily Corse, Michele De Palma, and Alfred Zippelius

    PNAS January 7, 2020 117 (1) 541-551; first published December 30, 2019. https://doi.org/10.1073/pnas.1902145116

• Medical Sciences

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    Unexpected intracellular biodegradation and recrystallization of gold nanoparticles

    Alice Balfourier, Nathalie Luciani, Guillaume Wang, Gerald Lelong, Ovidiu Ersen, Abdelali Khelfa, Damien Alloyeau, Florence Gazeau, and Florent Carn

    PNAS January 7, 2020 117 (1) 103-113; first published December 18, 2019. https://doi.org/10.1073/pnas.1911734116
  • Open Access

    HLA and autoantibodies define scleroderma subtypes and risk in African and European Americans and suggest a role for molecular mimicry

    Pravitt Gourh, Sarah A. Safran, Theresa Alexander, Steven E. Boyden, Nadia D. Morgan, Ami A. Shah, Maureen D. Mayes, Ayo Doumatey, Amy R. Bentley, Daniel Shriner, Robyn T. Domsic, Thomas A. Medsger Jr, Paula S. Ramos, Richard M. Silver, Virginia D. Steen, John Varga, Vivien Hsu, Lesley Ann Saketkoo, Elena Schiopu, Dinesh Khanna, Jessica K. Gordon, Brynn Kron, Lindsey A. Criswell, Heather Gladue, Chris T. Derk, Elana J. Bernstein, S. Louis Bridges Jr, Victoria K. Shanmugam, Kathleen D. Kolstad, Lorinda Chung, Suzanne Kafaja, Reem Jan, Marcin Trojanowski, Avram Goldberg, Benjamin D. Korman, Peter J. Steinbach, Settara C. Chandrasekharappa, James C. Mullikin, Adebowale Adeyemo, Charles Rotimi, Fredrick M. Wigley, Daniel L. Kastner, Francesco Boin, and Elaine F. Remmers

    PNAS January 7, 2020 117 (1) 552-562; first published December 23, 2019. https://doi.org/10.1073/pnas.1906593116
  • Open Access

    A genetically defined disease model reveals that urothelial cells can initiate divergent bladder cancer phenotypes

    Liang Wang, Bryan A. Smith, Nikolas G. Balanis, Brandon L. Tsai, Kim Nguyen, Michael W. Cheng, Matthew B. Obusan, Favour N. Esedebe, Saahil J. Patel, Hanwei Zhang, Peter M. Clark, Anthony E. Sisk, Jonathan W. Said, Jiaoti Huang, Thomas G. Graeber, Owen N. Witte, Arnold I. Chin, and Jung Wook Park

    PNAS January 7, 2020 117 (1) 563-572; first published December 23, 2019. https://doi.org/10.1073/pnas.1915770117
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    Ultraviolet A light induces DNA damage and estrogen-DNA adducts in Fuchs endothelial corneal dystrophy causing females to be more affected

    Cailing Liu, Taiga Miyajima, Geetha Melangath, Takashi Miyai, Shivakumar Vasanth, Neha Deshpande, Varun Kumar, Stephan Ong Tone, Reena Gupta, Shan Zhu, Dijana Vojnovic, Yuming Chen, Eleanor G. Rogan, Bodhiswatta Mondal, Muhammad Zahid, and Ula V. Jurkunas

    PNAS January 7, 2020 117 (1) 573-583; first published December 18, 2019. https://doi.org/10.1073/pnas.1912546116
  • Open Access

    FBXW7-mediated stability regulation of signal transducer and activator of transcription 2 in melanoma formation

    Cheol-Jung Lee, Hyun-Jung An, Seung-Min Kim, Sun-Mi Yoo, Juhee Park, Ga-Eun Lee, Woo-Young Kim, Dae Joon Kim, Han Chang Kang, Joo Young Lee, Hye Suk Lee, Sung-Jun Cho, and Yong-Yeon Cho

    PNAS January 7, 2020 117 (1) 584-594; first published December 16, 2019. https://doi.org/10.1073/pnas.1909879116

• Microbiology

  • Open Access

    Growth-rate dependent resource investment in bacterial motile behavior quantitatively follows potential benefit of chemotaxis

    Bin Ni, Remy Colin, Hannes Link, Robert G. Endres, and Victor Sourjik

    PNAS January 7, 2020 117 (1) 595-601; first published December 23, 2019. https://doi.org/10.1073/pnas.1910849117
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    Regulating vitamin B12 biosynthesis via the cbiMCbl riboswitch in Propionibacterium strain UF1

    Jing Li, Yong Ge, Mojgan Zadeh, Roy Curtiss III, and Mansour Mohamadzadeh

    PNAS January 7, 2020 117 (1) 602-609; first published December 13, 2019. https://doi.org/10.1073/pnas.1916576116
  • Open Access

    Retroviruses drive the rapid evolution of mammalian APOBEC3 genes

    Jumpei Ito, Robert J. Gifford, and Kei Sato

    PNAS January 7, 2020 117 (1) 610-618; first published December 16, 2019. https://doi.org/10.1073/pnas.1914183116
  • Open Access

    Divergent evolutionary trajectories of influenza B viruses underlie their contemporaneous epidemic activity

    Ramandeep K. Virk, Jayanthi Jayakumar, Ian H. Mendenhall, Mahesh Moorthy, Pauline Lam, Martin Linster, Julia Lim, Cui Lin, Lynette L. E. Oon, Hong Kai Lee, Evelyn S. C. Koay, Dhanasekaran Vijaykrishna, Gavin J. D. Smith, and Yvonne C. F. Su

    PNAS January 7, 2020 117 (1) 619-628; first published December 16, 2019. https://doi.org/10.1073/pnas.1916585116
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    Mycobacterial HflX is a ribosome splitting factor that mediates antibiotic resistance

    Paulami Rudra, Kelley R. Hurst-Hess, Katherine L. Cotten, Andrea Partida-Miranda, and Pallavi Ghosh

    PNAS January 7, 2020 117 (1) 629-634; first published December 23, 2019. https://doi.org/10.1073/pnas.1906748117
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    Abortive herpes simplex virus infection of nonneuronal cells results in quiescent viral genomes that can reactivate

    Efrat M. Cohen, Nir Avital, Meir Shamay, and Oren Kobiler

    PNAS January 7, 2020 117 (1) 635-640; first published December 23, 2019. https://doi.org/10.1073/pnas.1910537117

• Neuroscience

  • Open Access

    Early childhood deprivation is associated with alterations in adult brain structure despite subsequent environmental enrichment

    Nuria K. Mackes, Dennis Golm, Sagari Sarkar, Robert Kumsta, Michael Rutter, Graeme Fairchild, Mitul A. Mehta, Edmund J. S. Sonuga-Barke, and on behalf of the ERA Young Adult Follow-up team

    PNAS January 7, 2020 117 (1) 641-649; first published January 6, 2020. https://doi.org/10.1073/pnas.1911264116
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    Stress-induced modulation of endocannabinoid signaling leads to delayed strengthening of synaptic connectivity in the amygdala

    Farhana Yasmin, Roberto Colangeli, Maria Morena, Sarah Filipski, Mario van der Stelt, Quentin J. Pittman, Cecilia J. Hillard, G. Campbell Teskey, Bruce S. McEwen, Matthew N. Hill, and Sumantra Chattarji

    PNAS January 7, 2020 117 (1) 650-655; first published December 16, 2019. https://doi.org/10.1073/pnas.1910322116
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    Systematic phenomics analysis of autism-associated genes reveals parallel networks underlying reversible impairments in habituation

    • From the Cover

    Troy A. McDiarmid, Manuel Belmadani, Joseph Liang, Fabian Meili, Eleanor A. Mathews, Gregory P. Mullen, Ardalan Hendi, Wan-Rong Wong, James B. Rand, Kota Mizumoto, Kurt Haas, Paul Pavlidis, and Catharine H. Rankin

    PNAS January 7, 2020 117 (1) 656-667; first published November 21, 2019. https://doi.org/10.1073/pnas.1912049116

    See companion article:

    • Functional testing of ASD-associated genes

      - Dec 10, 2019
  • Open Access

    Imaging the effect of the circadian light–dark cycle on the glymphatic system in awake rats

    Xuezhu Cai, Ju Qiao, Praveen Kulkarni, Ian C. Harding, Eno Ebong, and Craig F. Ferris

    PNAS January 7, 2020 117 (1) 668-676; first published December 17, 2019. https://doi.org/10.1073/pnas.1914017117
  • Open Access

    Chorea-related mutations in PDE10A result in aberrant compartmentalization and functionality of the enzyme

    Gonzalo S. Tejeda, Ellanor L. Whiteley, Tarek Z. Deeb, Roland W. Bürli, Stephen J. Moss, Eamonn Sheridan, Nicholas J. Brandon, and George S. Baillie

    PNAS January 7, 2020 117 (1) 677-688; first published December 23, 2019. https://doi.org/10.1073/pnas.1916398117
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    Distinct effects of reward and navigation history on hippocampal forward and reverse replays

    Baburam Bhattarai, Jong Won Lee, and Min Whan Jung

    PNAS January 7, 2020 117 (1) 689-697; first published December 23, 2019. https://doi.org/10.1073/pnas.1912533117
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    A dual role for peripheral GDNF signaling in nociception and cardiovascular reflexes in the mouse

    Luis F. Queme, Alex A. Weyler, Elysia R. Cohen, Renita C. Hudgins, and Michael P. Jankowski

    PNAS January 7, 2020 117 (1) 698-707; first published December 17, 2019. https://doi.org/10.1073/pnas.1910905116
  • Open Access

    The olfactory basis of orchid pollination by mosquitoes

    Chloé Lahondère, Clément Vinauger, Ryo P. Okubo, Gabriella H. Wolff, Jeremy K. Chan, Omar S. Akbari, and Jeffrey A. Riffell

    PNAS January 7, 2020 117 (1) 708-716; first published December 23, 2019. https://doi.org/10.1073/pnas.1910589117

• Physiology

  • Open Access

    Shear force sensing of epithelial Na⁺ channel (ENaC) relies on N-glycosylated asparagines in the palm and knuckle domains of αENaC

    Fenja Knoepp, Zoe Ashley, Daniel Barth, Jan-Peter Baldin, Michael Jennings, Marina Kazantseva, Eng Leng Saw, Rajesh Katare, Diego Alvarez de la Rosa, Norbert Weissmann, and Martin Fronius

    PNAS January 7, 2020 117 (1) 717-726; first published December 23, 2019. https://doi.org/10.1073/pnas.1911243117

• Plant Biology

  • Open Access

    OsmiR528 regulates rice-pollen intine formation by targeting an uclacyanin to influence flavonoid metabolism

    Yu-Chan Zhang, Rui-Rui He, Jian-Ping Lian, Yan-Fei Zhou, Fan Zhang, Quan-Feng Li, Yang Yu, Yan-Zhao Feng, Yu-Wei Yang, Meng-Qi Lei, Huang He, Zhi Zhang, and Yue-Qin Chen

    PNAS January 7, 2020 117 (1) 727-732; first published December 23, 2019. https://doi.org/10.1073/pnas.1810968117
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    Evolution of vascular plants through redeployment of ancient developmental regulators

    Kuan-Ju Lu, Nicole van ’t Wout Hofland, Eliana Mor, Sumanth Mutte, Paul Abrahams, Hirotaka Kato, Klaas Vandepoele, Dolf Weijers, and Bert De Rybel

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• Psychological and Cognitive Sciences

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• Systems Biology

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