Short and simple sequences favored the emergence of N-helix phospho-ligand binding sites in the first enzymes
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Edited by William F. DeGrado, University of California, San Francisco, CA, and approved January 25, 2020 (received for review July 10, 2019)

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- Published in issue March 10, 2020.
- Published first February 20, 2020.
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- aDepartment of Biomolecular Sciences, Weizmann Institute of Science, 7610001 Rehovot, Israel;
- bScience for Life Laboratory, Department of Chemistry-BMC, Uppsala University, S-751 23 Uppsala, Sweden
Edited by William F. DeGrado, University of California, San Francisco, CA, and approved January 25, 2020 (received for review July 10, 2019)
Footnotes
↵1Present address: Hit Discovery, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, 431 83 Gothenburg, Sweden.
- ↵2To whom correspondence may be addressed. Email: dan.tawfik{at}weizmann.ac.il.
Author contributions: L.M.L., D.P., S.C.L.K., and D.S.T. designed research; L.M.L. and D.P. performed research; L.M.L., D.P., S.C.L.K., and D.S.T. analyzed data; and L.M.L. and D.S.T. wrote the paper with feedback from D.P. and S.C.L.K.
The authors declare no competing interest.
This article is a PNAS Direct Submission.
This article contains supporting information online at https://www.pnas.org/lookup/suppl/doi:10.1073/pnas.1911742117/-/DCSupplemental.
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