Table of Contents

Biological Sciences

• Applied Biological Sciences

  • Open Access

    Sonoselective transfection of cerebral vasculature without blood–brain barrier disruption

    Catherine M. Gorick, Alexander S. Mathew, William J. Garrison, E. Andrew Thim, Delaney G. Fisher, Caitleen A. Copeland, Ji Song, Alexander L. Klibanov, G. Wilson Miller, and Richard J. Price

    PNAS March 17, 2020 117 (11) 5644-5654; first published March 2, 2020. https://doi.org/10.1073/pnas.1914595117

• Biochemistry

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    Systematic identification of engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugation

    Susanna K. Elledge, Hai L. Tran, Alec H. Christian, Veronica Steri, Byron Hann, F. Dean Toste, Christopher J. Chang, and James A. Wells

    PNAS March 17, 2020 117 (11) 5733-5740; first published March 2, 2020. https://doi.org/10.1073/pnas.1920561117
  • Open Access

    In vitro selection of ribozyme ligases that use prebiotically plausible 2-aminoimidazole–activated substrates

    Travis Walton, Saurja DasGupta, Daniel Duzdevich, Seung Soo Oh, and Jack W. Szostak

    PNAS March 17, 2020 117 (11) 5741-5748; first published March 2, 2020. https://doi.org/10.1073/pnas.1914367117
  • Open Access

    Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism

    Eylan Yutuc, Roberto Angelini, Mark Baumert, Natalia Mast, Irina Pikuleva, Jillian Newton, Malcolm R. Clench, David O. F. Skibinski, Owain W. Howell, Yuqin Wang, and William J. Griffiths

    PNAS March 17, 2020 117 (11) 5749-5760; first published March 4, 2020. https://doi.org/10.1073/pnas.1917421117
  • Open Access

    Circadian control of interferon-sensitive gene expression in murine skin

    Elyse Noelani Greenberg, Michaela Ellen Marshall, Suoqin Jin, Sanan Venkatesh, Morgan Dragan, Lam C. Tsoi, Johann E. Gudjonsson, Qing Nie, Joseph S. Takahashi, and Bogi Andersen

    PNAS March 17, 2020 117 (11) 5761-5771; first published March 4, 2020. https://doi.org/10.1073/pnas.1915773117
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    Conformational control of small GTPases by AMPylation

    Katja Barthelmes, Evelyn Ramcke, Hyun-Seo Kang, Michael Sattler, and Aymelt Itzen

    PNAS March 17, 2020 117 (11) 5772-5781; first published March 2, 2020. https://doi.org/10.1073/pnas.1917549117
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    SOX4-mediated repression of specific tRNAs inhibits proliferation of human glioblastoma cells

    Jianjing Yang, Derek K. Smith, Haoqi Ni, Ke Wu, Dongdong Huang, Sishi Pan, Adwait A. Sathe, Yu Tang, Meng-Lu Liu, Chao Xing, Chun-Li Zhang, and Qichuan Zhuge

    PNAS March 17, 2020 117 (11) 5782-5790; first published March 2, 2020. https://doi.org/10.1073/pnas.1920200117
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    bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA)

    Shuhui Lim, Regina Khoo, Khong Ming Peh, Jinkai Teo, Shih Chieh Chang, Simon Ng, Greg L. Beilhartz, Roman A. Melnyk, Charles W. Johannes, Christopher J. Brown, David P. Lane, Brian Henry, and Anthony W. Partridge

    PNAS March 17, 2020 117 (11) 5791-5800; first published March 2, 2020. https://doi.org/10.1073/pnas.1920251117
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    RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription

    Lingting Li, Vadim Molodtsov, Wei Lin, Richard H. Ebright, and Yu Zhang

    PNAS March 17, 2020 117 (11) 5801-5809; first published March 3, 2020. https://doi.org/10.1073/pnas.1920747117
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    Plasmodium chaperonin TRiC/CCT identified as a target of the antihistamine clemastine using parallel chemoproteomic strategy

    Kuan-Yi Lu, Baiyi Quan, Kayla Sylvester, Tamanna Srivastava, Michael C. Fitzgerald, and Emily R. Derbyshire

    PNAS March 17, 2020 117 (11) 5810-5817; first published March 3, 2020. https://doi.org/10.1073/pnas.1913525117
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    Mechanism of proton transfer in class A β-lactamase catalysis and inhibition by avibactam

    Orville A. Pemberton, Radwan E. Noor, Vasantha Kumar M. V., Ruslan Sanishvili, M. Trent Kemp, Fiona L. Kearns, H. Lee Woodcock, Ioannis Gelis, and Yu Chen

    PNAS March 17, 2020 117 (11) 5818-5825; first published March 2, 2020. https://doi.org/10.1073/pnas.1922203117
  • Open Access

    Composition-based prediction and rational manipulation of prion-like domain recruitment to stress granules

    Amy E. Boncella, Jenifer E. Shattuck, Sean M. Cascarina, Kacy R. Paul, Matthew H. Baer, Anastasia Fomicheva, Andrew K. Lamb, and Eric D. Ross

    PNAS March 17, 2020 117 (11) 5826-5835; first published March 3, 2020. https://doi.org/10.1073/pnas.1912723117

• Biophysics and Computational Biology

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    Investigations of the underlying mechanisms of HIF-1α and CITED2 binding to TAZ1

    Wen-Ting Chu, Xiakun Chu, and Jin Wang

    PNAS March 17, 2020 117 (11) 5595-5603; first published March 2, 2020. https://doi.org/10.1073/pnas.1915333117
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    Mechanophenotyping of 3D multicellular clusters using displacement arrays of rendered tractions

    Susan E. Leggett, Mohak Patel, Thomas M. Valentin, Lena Gamboa, Amanda S. Khoo, Evelyn Kendall Williams, Christian Franck, and Ian Y. Wong

    PNAS March 17, 2020 117 (11) 5655-5663; first published March 2, 2020. https://doi.org/10.1073/pnas.1918296117
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    The atomistic level structure for the activated human κ-opioid receptor bound to the full Gi protein and the MP1104 agonist

    • From the Cover

    Amirhossein Mafi, Soo-Kyung Kim, and William A. Goddard III

    PNAS March 17, 2020 117 (11) 5836-5843; first published March 3, 2020. https://doi.org/10.1073/pnas.1910006117

    See companion article:

    • The quest for high-resolution G protein-coupled receptor–G protein structures

      - Mar 16, 2020
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    Abrogation of prenucleation, transient oligomerization of the Huntingtin exon 1 protein by human profilin I

    Alberto Ceccon, Vitali Tugarinov, Rodolfo Ghirlando, and G. Marius Clore

    PNAS March 17, 2020 117 (11) 5844-5852; first published March 3, 2020. https://doi.org/10.1073/pnas.1922264117
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    Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling

    Ivan E. Ivanov, Addison V. Wright, Joshua C. Cofsky, Kevin D. Palacio Aris, Jennifer A. Doudna, and Zev Bryant

    PNAS March 17, 2020 117 (11) 5853-5860; first published March 2, 2020. https://doi.org/10.1073/pnas.1913445117
  • Open Access

    Charge-dependent interactions of monomeric and filamentous actin with lipid bilayers

    Carsten F. E. Schroer, Lucia Baldauf, Lennard van Buren, Tsjerk A. Wassenaar, Manuel N. Melo, Gijsje H. Koenderink, and Siewert J. Marrink

    PNAS March 17, 2020 117 (11) 5861-5872; first published March 2, 2020. https://doi.org/10.1073/pnas.1914884117
  • Open Access

    Epistatic contributions promote the unification of incompatible models of neutral molecular evolution

    Jose Alberto de la Paz, Charisse M. Nartey, Monisha Yuvaraj, and Faruck Morcos

    PNAS March 17, 2020 117 (11) 5873-5882; first published March 2, 2020. https://doi.org/10.1073/pnas.1913071117

    See companion article:

    • Reply to Patel and Kumar: Epistasis not critical to rate distributions but key in heterotachy, overdispersion, and evolutionary Stokes shift

      - Apr 19, 2021
  • Open Access

    TDP-43 α-helical structure tunes liquid–liquid phase separation and function

    Alexander E. Conicella, Gregory L. Dignon, Gül H. Zerze, Hermann Broder Schmidt, Alexandra M. D’Ordine, Young C. Kim, Rajat Rohatgi, Yuna M. Ayala, Jeetain Mittal, and Nicolas L. Fawzi

    PNAS March 17, 2020 117 (11) 5883-5894; first published March 4, 2020. https://doi.org/10.1073/pnas.1912055117
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    An allosteric switch regulates Mycobacterium tuberculosis ClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR

    Siavash Vahidi, Zev A. Ripstein, Jordan B. Juravsky, Enrico Rennella, Alfred L. Goldberg, Anthony K. Mittermaier, John L. Rubinstein, and Lewis E. Kay

    PNAS March 17, 2020 117 (11) 5895-5906; first published March 2, 2020. https://doi.org/10.1073/pnas.1921630117

    See companion article:

    • Could confounding the allosteric communication of biotic machinery be an alternative path to antibiotics?

      - Mar 20, 2020
  • Open Access

    Frameshifting preserves key physicochemical properties of proteins

    Lukas Bartonek, Daniel Braun, and Bojan Zagrovic

    PNAS March 17, 2020 117 (11) 5907-5912; first published March 3, 2020. https://doi.org/10.1073/pnas.1911203117

• Cell Biology

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    Tetraspanin-6 negatively regulates exosome production

    Rania Ghossoub, Marion Chéry, Stéphane Audebert, Raphael Leblanc, Antonio Luis Egea-Jimenez, Frédérique Lembo, Sarah Mammar, Flavien Le Dez, Luc Camoin, Jean-Paul Borg, Eric Rubinstein, Guido David, and Pascale Zimmermann

    PNAS March 17, 2020 117 (11) 5913-5922; first published February 27, 2020. https://doi.org/10.1073/pnas.1922447117
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    Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancer

    Rushendhiran Kesavan, Timo Frömel, Sven Zukunft, Hebatullah Laban, Alexandra Geyer, Zumer Naeem, Juliana Heidler, Ilka Wittig, Eiman Elwakeel, Bernhard Brüne, Andreas Weigert, Rüdiger Popp, and Ingrid Fleming

    PNAS March 17, 2020 117 (11) 5923-5930; first published March 2, 2020. https://doi.org/10.1073/pnas.1921381117
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    The functional activity of E-cadherin controls tumor cell metastasis at multiple steps

    Tae-Young Na, Leslayann Schecterson, Alisha M. Mendonsa, and Barry M. Gumbiner

    PNAS March 17, 2020 117 (11) 5931-5937; first published March 3, 2020. https://doi.org/10.1073/pnas.1918167117

• Developmental Biology

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    Unique reproductive strategy in the swamp wallaby

    Brandon R. Menzies, Thomas B. Hildebrandt, and Marilyn B. Renfree

    PNAS March 17, 2020 117 (11) 5938-5942; first published March 2, 2020. https://doi.org/10.1073/pnas.1922678117

• Ecology

  • Open Access

    Algal photophysiology drives darkening and melt of the Greenland Ice Sheet

    • From the Cover

    Christopher J. Williamson, Joseph Cook, Andrew Tedstone, Marian Yallop, Jenine McCutcheon, Ewa Poniecka, Douglas Campbell, Tristram Irvine-Fynn, James McQuaid, Martyn Tranter, Rupert Perkins, and Alexandre Anesio

    PNAS March 17, 2020 117 (11) 5694-5705; first published February 24, 2020. https://doi.org/10.1073/pnas.1918412117

• Environmental Sciences

  • Open Access

    Microbial evolutionary strategies in a dynamic ocean

    Nathan G. Walworth, Emily J. Zakem, John P. Dunne, Sinéad Collins, and Naomi M. Levine

    PNAS March 17, 2020 117 (11) 5943-5948; first published March 2, 2020. https://doi.org/10.1073/pnas.1919332117
  • Open Access

    Assessing the role of live poultry trade in community-structured transmission of avian influenza in China

    • From the Cover

    Qiqi Yang, Xiang Zhao, Philippe Lemey, Marc A. Suchard, Yuhai Bi, Weifeng Shi, Di Liu, Wenbao Qi, Guogang Zhang, Nils Chr. Stenseth, Oliver G. Pybus, and Huaiyu Tian

    PNAS March 17, 2020 117 (11) 5949-5954; first published March 2, 2020. https://doi.org/10.1073/pnas.1906954117

• Evolution

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    Sympatric speciation of wild emmer wheat driven by ecology and chromosomal rearrangements

    Hongwei Wang, Huayan Yin, Chengzhi Jiao, Xiaojian Fang, Guiping Wang, Guangrong Li, Fei Ni, Penghuan Li, Peisen Su, Wenyang Ge, Zhongfan Lyu, Shoushen Xu, Yanhong Yang, Yongchao Hao, Xinxin Cheng, Jinxiao Zhao, Cheng Liu, Fengfeng Xu, Xin Ma, Silong Sun, Yan Zhao, Yinguang Bao, Cheng Liu, Jingjing Zhang, Tomas Pavlicek, Anfei Li, Zujun Yang, Eviatar Nevo, and Lingrang Kong

    PNAS March 17, 2020 117 (11) 5955-5963; first published March 2, 2020. https://doi.org/10.1073/pnas.1920415117
  • Open Access

    Dramatic dietary shift maintains sequestered toxins in chemically defended snakes

    Tatsuya Yoshida, Rinako Ujiie, Alan H. Savitzky, Teppei Jono, Takato Inoue, Naoko Yoshinaga, Shunsuke Aburaya, Wataru Aoki, Hirohiko Takeuchi, Li Ding, Qin Chen, Chengquan Cao, Tein-Shun Tsai, Anslem de Silva, Dharshani Mahaulpatha, Tao Thien Nguyen, Yezhong Tang, Naoki Mori, and Akira Mori

    PNAS March 17, 2020 117 (11) 5964-5969; first published February 24, 2020. https://doi.org/10.1073/pnas.1919065117
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    Clonemate cotransmission supports a role for kin selection in a puppeteer parasite

    Charles D. Criscione, Bradley J. van Paridon, John S. Gilleard, and Cameron P. Goater

    PNAS March 17, 2020 117 (11) 5970-5976; first published March 2, 2020. https://doi.org/10.1073/pnas.1922272117
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    Integrated structural and evolutionary analysis reveals common mechanisms underlying adaptive evolution in mammals

    Greg Slodkowicz and Nick Goldman

    PNAS March 17, 2020 117 (11) 5977-5986; first published March 2, 2020. https://doi.org/10.1073/pnas.1916786117

• Genetics

  • Open Access

    Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons

    Sylvia E. J. Fischer and Gary Ruvkun

    PNAS March 17, 2020 117 (11) 5987-5996; first published March 2, 2020. https://doi.org/10.1073/pnas.1919028117
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    Assessing thyroid cancer risk using polygenic risk scores

    Sandya Liyanarachchi, Julius Gudmundsson, Egil Ferkingstad, Huiling He, Jon G. Jonasson, Vinicius Tragante, Folkert W. Asselbergs, Li Xu, Lambertus A. Kiemeney, Romana T. Netea-Maier, Jose I. Mayordomo, Theo S. Plantinga, Hannes Hjartarson, Jon Hrafnkelsson, Erich M. Sturgis, Pamela Brock, Fadi Nabhan, Gudmar Thorleifsson, Matthew D. Ringel, Kari Stefansson, and Albert de la Chapelle

    PNAS March 17, 2020 117 (11) 5997-6002; first published March 4, 2020. https://doi.org/10.1073/pnas.1919976117
  • Open Access

    The regulatory and transcriptional landscape associated with carbon utilization in a filamentous fungus

    Vincent W. Wu, Nils Thieme, Lori B. Huberman, Axel Dietschmann, David J. Kowbel, Juna Lee, Sara Calhoun, Vasanth R. Singan, Anna Lipzen, Yi Xiong, Remo Monti, Matthew J. Blow, Ronan C. O’Malley, Igor V. Grigoriev, J. Philipp Benz, and N. Louise Glass

    PNAS March 17, 2020 117 (11) 6003-6013; first published February 28, 2020. https://doi.org/10.1073/pnas.1915611117
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    Sensory cilia as the Achilles heel of nematodes when attacked by carnivorous mushrooms

    • From the Cover

    Ching-Han Lee, Han-Wen Chang, Ching-Ting Yang, Niaz Wali, Jiun-Jie Shie, and Yen-Ping Hsueh

    PNAS March 17, 2020 117 (11) 6014-6022; first published March 2, 2020. https://doi.org/10.1073/pnas.1918473117

    See companion article:

    • Natural diversity in the predatory behavior facilitates the establishment of a robust model strain for nematode-trapping fungi

      - Mar 11, 2020

    See companion article:

    • Mechanism of murderous mushrooms paves path for parasitic helminth halt

      - Mar 09, 2020
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    Loss-of-function BK channel mutation causes impaired mitochondria and progressive cerebellar ataxia

    Xiaofei Du, Joao L. Carvalho-de-Souza, Cenfu Wei, Willy Carrasquel-Ursulaez, Yenisleidy Lorenzo, Naileth Gonzalez, Tomoya Kubota, Julia Staisch, Timothy Hain, Natalie Petrossian, Michael Xu, Ramon Latorre, Francisco Bezanilla, and Christopher M. Gomez

    PNAS March 17, 2020 117 (11) 6023-6034; first published March 4, 2020. https://doi.org/10.1073/pnas.1920008117
  • Open Access

    DNA polymerase δ proofreads errors made by DNA polymerase ε

    Chelsea R. Bulock, Xuanxuan Xing, and Polina V. Shcherbakova

    PNAS March 17, 2020 117 (11) 6035-6041; first published March 2, 2020. https://doi.org/10.1073/pnas.1917624117

• Immunology and Inflammation

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    Regulatory CD8 T cells that recognize Qa-1 expressed by CD4 T-helper cells inhibit rejection of heart allografts

    John Y. Choi, Siawosh K. Eskandari, Songjie Cai, Ina Sulkaj, Jean Pierre Assaker, Hazim Allos, Juliano AlHaddad, Saif A. Muhsin, Eman Alhussain, Amr Mansouri, Melissa Y. Yeung, Marc A. J. Seelen, Hye-Jung Kim, Harvey Cantor, and Jamil R. Azzi

    PNAS March 17, 2020 117 (11) 6042-6046; first published February 28, 2020. https://doi.org/10.1073/pnas.1918950117
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    Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8⁺ T cell stemness and antitumor immunity

    Dalton Hermans, Sanjivan Gautam, Juan C. García-Cañaveras, Daniel Gromer, Suman Mitra, Rosanne Spolski, Peng Li, Stephen Christensen, Rosa Nguyen, Jian-Xin Lin, Jangsuk Oh, Ning Du, Sharon Veenbergen, Jessica Fioravanti, Risa Ebina-Shibuya, Christopher Bleck, Leonard M. Neckers, Joshua D. Rabinowitz, Luca Gattinoni, and Warren J. Leonard

    PNAS March 17, 2020 117 (11) 6047-6055; first published March 2, 2020. https://doi.org/10.1073/pnas.1920413117
  • Open Access

    Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism

    Adam P. Cribbs, Stefan Terlecki-Zaniewicz, Martin Philpott, Jeroen Baardman, David Ahern, Morten Lindow, Susanna Obad, Henrik Oerum, Brante Sampey, Palwinder K. Mander, Henry Penn, Paul Wordsworth, Paul Bowness, Menno de Winther, Rab K. Prinjha, Marc Feldmann, and Udo Oppermann

    PNAS March 17, 2020 117 (11) 6056-6066; first published March 2, 2020. https://doi.org/10.1073/pnas.1919893117
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    Signaling mechanisms of growth hormone-releasing hormone receptor in LPS-induced acute ocular inflammation

    Wei Cheng Liang, Jia Lin Ren, Qiu Xiao Yu, Jian Li, Tsz Kin Ng, Wai Kit Chu, Yong Jie Qin, Kai On Chu, Andrew V. Schally, Chi Pui Pang, and Sun On Chan

    PNAS March 17, 2020 117 (11) 6067-6074; first published March 2, 2020. https://doi.org/10.1073/pnas.1904532117

• Medical Sciences

  • Open Access

    Abrogation of esophageal carcinoma development in miR-31 knockout rats

    Louise Y. Fong, Cristian Taccioli, Alexey Palamarchuk, Guidantonio Malagoli Tagliazucchi, Ruiyan Jing, Karl J. Smalley, Sili Fan, Joseph Altemus, Oliver Fiehn, Kay Huebner, John L. Farber, and Carlo M. Croce

    PNAS March 17, 2020 117 (11) 6075-6085; first published March 2, 2020. https://doi.org/10.1073/pnas.1920333117
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    Immunotoxin SS1P is rapidly removed by proximal tubule cells of kidney, whose damage contributes to albumin loss in urine

    Xui-Fen Liu, Junxia Wei, Qi Zhou, Bruce A. Molitoris, Ruben Sandoval, Hisataka Kobayashi, Ryuhei Okada, Tadanobu Nagaya, Baktiar Karim, Donna Butcher, and Ira Pastan

    PNAS March 17, 2020 117 (11) 6086-6091; first published March 2, 2020. https://doi.org/10.1073/pnas.1919038117
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    Regulation of B cell receptor-dependent NF-κB signaling by the tumor suppressor KLHL14

    Jaewoo Choi, James D. Phelan, George W. Wright, Björn Häupl, Da Wei Huang, Arthur L. Shaffer III, Ryan M. Young, Zhuo Wang, Hong Zhao, Xin Yu, Thomas Oellerich, and Louis M. Staudt

    PNAS March 17, 2020 117 (11) 6092-6102; first published March 3, 2020. https://doi.org/10.1073/pnas.1921187117
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    A hepatocyte differentiation model reveals two subtypes of liver cancer with different oncofetal properties and therapeutic targets

    Ming Liu, Qian Yan, Yi Sun, Yoonhee Nam, Liang Hu, Jane HC Loong, Qi Ouyang, Yu Zhang, Hao-Long Li, Fan-En Kong, Lei Li, Yan Li, Mei-Mei Li, Wei Cheng, Ling-Xi Jiang, Shuo Fang, Xiao-Dong Yang, Jia-Qiang Mo, Yuan-Feng Gong, Yun-Qiang Tang, Yan Li, Yun-Fei Yuan, Ning-Fang Ma, Ge Lin, Stephanie Ma, Ji-Guang Wang, and Xin-Yuan Guan

    PNAS March 17, 2020 117 (11) 6103-6113; first published March 2, 2020. https://doi.org/10.1073/pnas.1912146117

• Microbiology

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    Biphasic chemotaxis of Escherichia coli to the microbiota metabolite indole

    Jingyun Yang, Ravi Chawla, Kathy Y. Rhee, Rachit Gupta, Michael D. Manson, Arul Jayaraman, and Pushkar P. Lele

    PNAS March 17, 2020 117 (11) 6114-6120; first published March 2, 2020. https://doi.org/10.1073/pnas.1916974117
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    Cell-penetrating peptide inhibits retromer-mediated human papillomavirus trafficking during virus entry

    Pengwei Zhang, Ruben Moreno, Paul F. Lambert, and Daniel DiMaio

    PNAS March 17, 2020 117 (11) 6121-6128; first published March 2, 2020. https://doi.org/10.1073/pnas.1917748117
  • Open Access

    Class A PBPs have a distinct and unique role in the construction of the pneumococcal cell wall

    Daniel Straume, Katarzyna Wiaroslawa Piechowiak, Silje Olsen, Gro Anita Stamsås, Kari Helene Berg, Morten Kjos, Maria Victoria Heggenhougen, Martín Alcorlo, Juan A. Hermoso, and Leiv Sigve Håvarstein

    PNAS March 17, 2020 117 (11) 6129-6138; first published March 2, 2020. https://doi.org/10.1073/pnas.1917820117
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    Structural elucidation of the Clostridioides difficile transferase toxin reveals a single-site binding mode for the enzyme

    Michael J. Sheedlo, David M. Anderson, Audrey K. Thomas, and D. Borden Lacy

    PNAS March 17, 2020 117 (11) 6139-6144; first published March 2, 2020. https://doi.org/10.1073/pnas.1920555117
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    Visualizing the translation and packaging of HIV-1 full-length RNA

    Jianbo Chen, Yang Liu, Bin Wu, Olga A. Nikolaitchik, Preeti R. Mohan, Jiji Chen, Vinay K. Pathak, and Wei-Shau Hu

    PNAS March 17, 2020 117 (11) 6145-6155; first published March 4, 2020. https://doi.org/10.1073/pnas.1917590117

• Neuroscience

  • Open Access

    The neural signature of numerosity by separating numerical and continuous magnitude extraction in visual cortex with frequency-tagged EEG

    Amandine Van Rinsveld, Mathieu Guillaume, Peter J. Kohler, Christine Schiltz, Wim Gevers, and Alain Content

    PNAS March 17, 2020 117 (11) 5726-5732; first published March 2, 2020. https://doi.org/10.1073/pnas.1917849117
  • Open Access

    Active efficient coding explains the development of binocular vision and its failure in amblyopia

    Samuel Eckmann, Lukas Klimmasch, Bertram E. Shi, and Jochen Triesch

    PNAS March 17, 2020 117 (11) 6156-6162; first published March 2, 2020. https://doi.org/10.1073/pnas.1908100117
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    Connectivity at the origins of domain specificity in the cortical face and place networks

    Frederik S. Kamps, Cassandra L. Hendrix, Patricia A. Brennan, and Daniel D. Dilks

    PNAS March 17, 2020 117 (11) 6163-6169; first published March 2, 2020. https://doi.org/10.1073/pnas.1911359117
  • Open Access

    Diet modulates brain network stability, a biomarker for brain aging, in young adults

    Lilianne R. Mujica-Parodi, Anar Amgalan, Syed Fahad Sultan, Botond Antal, Xiaofei Sun, Steven Skiena, Andrew Lithen, Noor Adra, Eva-Maria Ratai, Corey Weistuch, Sindhuja Tirumalai Govindarajan, Helmut H. Strey, Ken A. Dill, Steven M. Stufflebeam, Richard L. Veech, and Kieran Clarke

    PNAS March 17, 2020 117 (11) 6170-6177; first published March 3, 2020. https://doi.org/10.1073/pnas.1913042117
  • Open Access

    Context-dependent operation of neural circuits underlies a navigation behavior in Caenorhabditis elegans

    Muneki Ikeda, Shunji Nakano, Andrew C. Giles, Linghuan Xu, Wagner Steuer Costa, Alexander Gottschalk, and Ikue Mori

    PNAS March 17, 2020 117 (11) 6178-6188; first published March 2, 2020. https://doi.org/10.1073/pnas.1918528117
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    Nf1 deletion results in depletion of the Lhx6 transcription factor and a specific loss of parvalbumin⁺ cortical interneurons

    Kartik Angara, Emily Ling-Lin Pai, Stephanie M. Bilinovich, April M. Stafford, Julie T. Nguyen, Katie X. Li, Anirban Paul, John L. Rubenstein, and Daniel Vogt

    PNAS March 17, 2020 117 (11) 6189-6195; first published March 2, 2020. https://doi.org/10.1073/pnas.1915458117
  • Open Access

    Anterior cingulate cortex is necessary for adaptation of action plans

    Adam T. Brockett, Stephen S. Tennyson, Coreylyn A. deBettencourt, Fatou Gaye, and Matthew R. Roesch

    PNAS March 17, 2020 117 (11) 6196-6204; first published March 4, 2020. https://doi.org/10.1073/pnas.1919303117

• Plant Biology

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    CUL3^BPM E3 ubiquitin ligases regulate MYC2, MYC3, and MYC4 stability and JA responses

    Jose Manuel Chico, Esther Lechner, Gemma Fernandez-Barbero, Esther Canibano, Gloria García-Casado, Jose Manuel Franco-Zorrilla, Philippe Hammann, Angel M. Zamarreño, Jose M. García-Mina, Vicente Rubio, Pascal Genschik, and Roberto Solano

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