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Table of Contents
March 17, 2020; vol. 117 no. 11
This Week in PNAS
Inner Workings
An over-the-shoulder look at scientists at work.
- You have accessInner Workings: Understanding the evolution of cell types to explain the roots of animal diversity
- Front Matter
Viviane Callier
Perspective
- You have accessScience is not a signal detection problemBrent M. Wilson, Christine R. Harris, and John T. WixtedPNAS March 17, 2020 117 (11) 5559-5567; first published March 3, 2020. https://doi.org/10.1073/pnas.1914237117
See companion article:
Letters
- You have accessComplex “human−vegetation−climate” interactions in the Late Holocene and their significance for paleotemperature reconstructionsYunxia Li, Yiping Tian, Haichun Guo, Shikai Wei, Jiantao Cao, Chao Huang, Fuxi Shi, and Zhiguo RaoPNAS March 17, 2020 117 (11) 5568-5570; first published February 21, 2020. https://doi.org/10.1073/pnas.1922325117
- You have accessReply to Li et al.: Human societies began to play a significant role in global sediment transfer 4,000 years agoJean-Philippe Jenny, Sujan Koirala, Irene Gregory-Eaves, Pierre Francus, Bernhard Ahrens, Victor Brovkin, Antti E. K. Ojala, Bernd Zolitschka, Juergen Bader, and Nuno CarvalhaisPNAS March 17, 2020 117 (11) 5571-5572; first published February 21, 2020. https://doi.org/10.1073/pnas.1922723117
See companion article:
- You have accessApes, adaptations, and artifacts of anestheticsBjarke Jensen and Tobias WangPNAS March 17, 2020 117 (11) 5573; first published February 20, 2020. https://doi.org/10.1073/pnas.1921494117
- You have accessReply to Jensen and Wang: Chimpanzees under pressure—Selection of a left ventricular structural and functional phenotypeRobert E. Shave, Daniel E. Lieberman, Aimee L. Drane, and Aaron L. BaggishPNAS March 17, 2020 117 (11) 5574-5575; first published February 20, 2020. https://doi.org/10.1073/pnas.1922202117
See companion article:
Physical Sciences
Applied Physical Sciences
- You have accessPossibility for inhibited spontaneous emission in electromagnetically open parity–time-symmetric guiding structuresYakir Hadad and Nader EnghetaPNAS March 17, 2020 117 (11) 5576-5581; first published March 2, 2020. https://doi.org/10.1073/pnas.1914279117
- You have accessCoherent phonon dynamics in spatially separated graphene mechanical resonatorsZhuo-Zhi Zhang, Xiang-Xiang Song, Gang Luo, Zi-Jia Su, Kai-Long Wang, Gang Cao, Hai-Ou Li, Ming Xiao, Guang-Can Guo, Lin Tian, Guang-Wei Deng, and Guo-Ping GuoPNAS March 17, 2020 117 (11) 5582-5587; first published March 2, 2020. https://doi.org/10.1073/pnas.1916978117
- You have accessIn situ healing of dendrites in a potassium metal batteryPrateek Hundekar, Swastik Basu, Xiulin Fan, Lu Li, Anthony Yoshimura, Tushar Gupta, Varun Sarbada, Aniruddha Lakhnot, Rishabh Jain, Shankar Narayanan, Yunfeng Shi, Chunsheng Wang, and Nikhil KoratkarPNAS March 17, 2020 117 (11) 5588-5594; first published March 2, 2020. https://doi.org/10.1073/pnas.1915470117
Biophysics and Computational Biology
- You have accessInvestigations of the underlying mechanisms of HIF-1α and CITED2 binding to TAZ1Wen-Ting Chu, Xiakun Chu, and Jin WangPNAS March 17, 2020 117 (11) 5595-5603; first published March 2, 2020. https://doi.org/10.1073/pnas.1915333117
- You have accessActive volume regulation in adhered cellsRam M. Adar and Samuel A. SafranPNAS March 17, 2020 117 (11) 5604-5609; first published March 4, 2020. https://doi.org/10.1073/pnas.1918203117
- You have accessThe atomistic level structure for the activated human κ-opioid receptor bound to the full Gi protein and the MP1104 agonist
- From the Cover
Amirhossein Mafi, Soo-Kyung Kim, and William A. Goddard IIIPNAS March 17, 2020 117 (11) 5836-5843; first published March 3, 2020. https://doi.org/10.1073/pnas.1910006117See companion article:
- You have accessAbrogation of prenucleation, transient oligomerization of the Huntingtin exon 1 protein by human profilin IAlberto Ceccon, Vitali Tugarinov, Rodolfo Ghirlando, and G. Marius ClorePNAS March 17, 2020 117 (11) 5844-5852; first published March 3, 2020. https://doi.org/10.1073/pnas.1922264117
- You have accessCas9 interrogates DNA in discrete steps modulated by mismatches and supercoilingIvan E. Ivanov, Addison V. Wright, Joshua C. Cofsky, Kevin D. Palacio Aris, Jennifer A. Doudna, and Zev BryantPNAS March 17, 2020 117 (11) 5853-5860; first published March 2, 2020. https://doi.org/10.1073/pnas.1913445117
- Open AccessCharge-dependent interactions of monomeric and filamentous actin with lipid bilayersCarsten F. E. Schroer, Lucia Baldauf, Lennard van Buren, Tsjerk A. Wassenaar, Manuel N. Melo, Gijsje H. Koenderink, and Siewert J. MarrinkPNAS March 17, 2020 117 (11) 5861-5872; first published March 2, 2020. https://doi.org/10.1073/pnas.1914884117
- Open AccessActive efficient coding explains the development of binocular vision and its failure in amblyopiaSamuel Eckmann, Lukas Klimmasch, Bertram E. Shi, and Jochen TrieschPNAS March 17, 2020 117 (11) 6156-6162; first published March 2, 2020. https://doi.org/10.1073/pnas.1908100117
Chemistry
- You have accessAssociation of Cl with C2H2 by unified variable-reaction-coordinate and reaction-path variational transition-state theoryLinyao Zhang, Donald G. Truhlar, and Shaozeng SunPNAS March 17, 2020 117 (11) 5610-5616; first published March 2, 2020. https://doi.org/10.1073/pnas.1920018117
- You have accessProgramming colloidal bonding using DNA strand-displacement circuitryXiang Zhou, Dongbao Yao, Wenqiang Hua, Ningdong Huang, Xiaowei Chen, Liangbin Li, Miao He, Yunhan Zhang, Yijun Guo, Shiyan Xiao, Fenggang Bian, and Haojun LiangPNAS March 17, 2020 117 (11) 5617-5623; first published March 4, 2020. https://doi.org/10.1073/pnas.1917941117
- You have accessSystematic identification of engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugationSusanna K. Elledge, Hai L. Tran, Alec H. Christian, Veronica Steri, Byron Hann, F. Dean Toste, Christopher J. Chang, and James A. WellsPNAS March 17, 2020 117 (11) 5733-5740; first published March 2, 2020. https://doi.org/10.1073/pnas.1920561117
Computer Sciences
- You have accessCommunication cost of consensus for nodes with limited memoryGiulia Fanti, Nina Holden, Yuval Peres, and Gireeja RanadePNAS March 17, 2020 117 (11) 5624-5630; first published March 4, 2020. https://doi.org/10.1073/pnas.1912980117
- Open AccessThe impossibility of low-rank representations for triangle-rich complex networksC. Seshadhri, Aneesh Sharma, Andrew Stolman, and Ashish GoelPNAS March 17, 2020 117 (11) 5631-5637; first published March 2, 2020. https://doi.org/10.1073/pnas.1911030117
Earth, Atmospheric, and Planetary Sciences
- You have accessStability of H3O at extreme conditions and implications for the magnetic fields of Uranus and NeptunePeihao Huang, Hanyu Liu, Jian Lv, Quan Li, Chunhong Long, Yanchao Wang, Changfeng Chen, Russell J. Hemley, and Yanming MaPNAS March 17, 2020 117 (11) 5638-5643; first published March 3, 2020. https://doi.org/10.1073/pnas.1921811117
- Open AccessMicrobial evolutionary strategies in a dynamic oceanNathan G. Walworth, Emily J. Zakem, John P. Dunne, Sinéad Collins, and Naomi M. LevinePNAS March 17, 2020 117 (11) 5943-5948; first published March 2, 2020. https://doi.org/10.1073/pnas.1919332117
Engineering
- Open AccessSonoselective transfection of cerebral vasculature without blood–brain barrier disruptionCatherine M. Gorick, Alexander S. Mathew, William J. Garrison, E. Andrew Thim, Delaney G. Fisher, Caitleen A. Copeland, Ji Song, Alexander L. Klibanov, G. Wilson Miller, and Richard J. PricePNAS March 17, 2020 117 (11) 5644-5654; first published March 2, 2020. https://doi.org/10.1073/pnas.1914595117
- You have accessMechanophenotyping of 3D multicellular clusters using displacement arrays of rendered tractionsSusan E. Leggett, Mohak Patel, Thomas M. Valentin, Lena Gamboa, Amanda S. Khoo, Evelyn Kendall Williams, Christian Franck, and Ian Y. WongPNAS March 17, 2020 117 (11) 5655-5663; first published March 2, 2020. https://doi.org/10.1073/pnas.1918296117
- You have accessThe effects of evolutionary adaptations on spreading processes in complex networksRashad Eletreby, Yong Zhuang, Kathleen M. Carley, Osman Yağan, and H. Vincent PoorPNAS March 17, 2020 117 (11) 5664-5670; first published March 2, 2020. https://doi.org/10.1073/pnas.1918529117
- Open AccessEmbedded droplet printing in yield-stress fluidsArif Z. Nelson, Binu Kundukad, Wai Kuan Wong, Saif A. Khan, and Patrick S. DoylePNAS March 17, 2020 117 (11) 5671-5679; first published March 3, 2020. https://doi.org/10.1073/pnas.1919363117
- You have accessHierarchically porous Au nanostructures with interconnected channels for efficient mass transport in electrocatalytic CO2 reductionGayea Hyun, Jun Tae Song, Changui Ahn, Youngjin Ham, Donghwi Cho, Jihun Oh, and Seokwoo JeonPNAS March 17, 2020 117 (11) 5680-5685; first published March 4, 2020. https://doi.org/10.1073/pnas.1918837117
- You have accessExtreme mechanical resilience of self-assembled nanolabyrinthine materialsCarlos M. Portela, A. Vidyasagar, Sebastian Krödel, Tamara Weissenbach, Daryl W. Yee, Julia R. Greer, and Dennis M. KochmannPNAS March 17, 2020 117 (11) 5686-5693; first published March 4, 2020. https://doi.org/10.1073/pnas.1916817117
Environmental Sciences
- Open AccessAlgal photophysiology drives darkening and melt of the Greenland Ice Sheet
- From the Cover
Christopher J. Williamson, Joseph Cook, Andrew Tedstone, Marian Yallop, Jenine McCutcheon, Ewa Poniecka, Douglas Campbell, Tristram Irvine-Fynn, James McQuaid, Martyn Tranter, Rupert Perkins, and Alexandre AnesioPNAS March 17, 2020 117 (11) 5694-5705; first published February 24, 2020. https://doi.org/10.1073/pnas.1918412117
Physics
- You have accessTopological transition in measurement-induced geometric phasesValentin Gebhart, Kyrylo Snizhko, Thomas Wellens, Andreas Buchleitner, Alessandro Romito, and Yuval GefenPNAS March 17, 2020 117 (11) 5706-5713; first published March 2, 2020. https://doi.org/10.1073/pnas.1911620117
- You have accessExperimental observation of the marginal glass phase in a colloidal glassAndrew P. Hammond and Eric I. CorwinPNAS March 17, 2020 117 (11) 5714-5718; first published March 3, 2020. https://doi.org/10.1073/pnas.1917283117
Social Sciences
Environmental Sciences
- You have accessCoastal wetlands reduce property damage during tropical cyclonesFanglin Sun and Richard T. CarsonPNAS March 17, 2020 117 (11) 5719-5725; first published March 2, 2020. https://doi.org/10.1073/pnas.1915169117
Psychological and Cognitive Sciences
- Open AccessThe neural signature of numerosity by separating numerical and continuous magnitude extraction in visual cortex with frequency-tagged EEGAmandine Van Rinsveld, Mathieu Guillaume, Peter J. Kohler, Christine Schiltz, Wim Gevers, and Alain ContentPNAS March 17, 2020 117 (11) 5726-5732; first published March 2, 2020. https://doi.org/10.1073/pnas.1917849117
- You have accessConnectivity at the origins of domain specificity in the cortical face and place networksFrederik S. Kamps, Cassandra L. Hendrix, Patricia A. Brennan, and Daniel D. DilksPNAS March 17, 2020 117 (11) 6163-6169; first published March 2, 2020. https://doi.org/10.1073/pnas.1911359117
- You have accessEye movements support behavioral pattern completionJordana S. Wynn, Jennifer D. Ryan, and Bradley R. BuchsbaumPNAS March 17, 2020 117 (11) 6246-6254; first published March 2, 2020. https://doi.org/10.1073/pnas.1917586117
Biological Sciences
Applied Biological Sciences
- Open AccessSonoselective transfection of cerebral vasculature without blood–brain barrier disruptionCatherine M. Gorick, Alexander S. Mathew, William J. Garrison, E. Andrew Thim, Delaney G. Fisher, Caitleen A. Copeland, Ji Song, Alexander L. Klibanov, G. Wilson Miller, and Richard J. PricePNAS March 17, 2020 117 (11) 5644-5654; first published March 2, 2020. https://doi.org/10.1073/pnas.1914595117
Biochemistry
- You have accessSystematic identification of engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugationSusanna K. Elledge, Hai L. Tran, Alec H. Christian, Veronica Steri, Byron Hann, F. Dean Toste, Christopher J. Chang, and James A. WellsPNAS March 17, 2020 117 (11) 5733-5740; first published March 2, 2020. https://doi.org/10.1073/pnas.1920561117
- Open AccessIn vitro selection of ribozyme ligases that use prebiotically plausible 2-aminoimidazole–activated substratesTravis Walton, Saurja DasGupta, Daniel Duzdevich, Seung Soo Oh, and Jack W. SzostakPNAS March 17, 2020 117 (11) 5741-5748; first published March 2, 2020. https://doi.org/10.1073/pnas.1914367117
- Open AccessLocalization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolismEylan Yutuc, Roberto Angelini, Mark Baumert, Natalia Mast, Irina Pikuleva, Jillian Newton, Malcolm R. Clench, David O. F. Skibinski, Owain W. Howell, Yuqin Wang, and William J. GriffithsPNAS March 17, 2020 117 (11) 5749-5760; first published March 4, 2020. https://doi.org/10.1073/pnas.1917421117
- Open AccessCircadian control of interferon-sensitive gene expression in murine skinElyse Noelani Greenberg, Michaela Ellen Marshall, Suoqin Jin, Sanan Venkatesh, Morgan Dragan, Lam C. Tsoi, Johann E. Gudjonsson, Qing Nie, Joseph S. Takahashi, and Bogi AndersenPNAS March 17, 2020 117 (11) 5761-5771; first published March 4, 2020. https://doi.org/10.1073/pnas.1915773117
- You have accessConformational control of small GTPases by AMPylationKatja Barthelmes, Evelyn Ramcke, Hyun-Seo Kang, Michael Sattler, and Aymelt ItzenPNAS March 17, 2020 117 (11) 5772-5781; first published March 2, 2020. https://doi.org/10.1073/pnas.1917549117
- You have accessSOX4-mediated repression of specific tRNAs inhibits proliferation of human glioblastoma cellsJianjing Yang, Derek K. Smith, Haoqi Ni, Ke Wu, Dongdong Huang, Sishi Pan, Adwait A. Sathe, Yu Tang, Meng-Lu Liu, Chao Xing, Chun-Li Zhang, and Qichuan ZhugePNAS March 17, 2020 117 (11) 5782-5790; first published March 2, 2020. https://doi.org/10.1073/pnas.1920200117
- You have accessbioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA)Shuhui Lim, Regina Khoo, Khong Ming Peh, Jinkai Teo, Shih Chieh Chang, Simon Ng, Greg L. Beilhartz, Roman A. Melnyk, Charles W. Johannes, Christopher J. Brown, David P. Lane, Brian Henry, and Anthony W. PartridgePNAS March 17, 2020 117 (11) 5791-5800; first published March 2, 2020. https://doi.org/10.1073/pnas.1920251117
- You have accessRNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcriptionLingting Li, Vadim Molodtsov, Wei Lin, Richard H. Ebright, and Yu ZhangPNAS March 17, 2020 117 (11) 5801-5809; first published March 3, 2020. https://doi.org/10.1073/pnas.1920747117
- You have accessPlasmodium chaperonin TRiC/CCT identified as a target of the antihistamine clemastine using parallel chemoproteomic strategyKuan-Yi Lu, Baiyi Quan, Kayla Sylvester, Tamanna Srivastava, Michael C. Fitzgerald, and Emily R. DerbyshirePNAS March 17, 2020 117 (11) 5810-5817; first published March 3, 2020. https://doi.org/10.1073/pnas.1913525117
- You have accessMechanism of proton transfer in class A β-lactamase catalysis and inhibition by avibactamOrville A. Pemberton, Radwan E. Noor, Vasantha Kumar M. V., Ruslan Sanishvili, M. Trent Kemp, Fiona L. Kearns, H. Lee Woodcock, Ioannis Gelis, and Yu ChenPNAS March 17, 2020 117 (11) 5818-5825; first published March 2, 2020. https://doi.org/10.1073/pnas.1922203117
- Open AccessComposition-based prediction and rational manipulation of prion-like domain recruitment to stress granulesAmy E. Boncella, Jenifer E. Shattuck, Sean M. Cascarina, Kacy R. Paul, Matthew H. Baer, Anastasia Fomicheva, Andrew K. Lamb, and Eric D. RossPNAS March 17, 2020 117 (11) 5826-5835; first published March 3, 2020. https://doi.org/10.1073/pnas.1912723117
Biophysics and Computational Biology
- You have accessInvestigations of the underlying mechanisms of HIF-1α and CITED2 binding to TAZ1Wen-Ting Chu, Xiakun Chu, and Jin WangPNAS March 17, 2020 117 (11) 5595-5603; first published March 2, 2020. https://doi.org/10.1073/pnas.1915333117
- You have accessMechanophenotyping of 3D multicellular clusters using displacement arrays of rendered tractionsSusan E. Leggett, Mohak Patel, Thomas M. Valentin, Lena Gamboa, Amanda S. Khoo, Evelyn Kendall Williams, Christian Franck, and Ian Y. WongPNAS March 17, 2020 117 (11) 5655-5663; first published March 2, 2020. https://doi.org/10.1073/pnas.1918296117
- You have accessThe atomistic level structure for the activated human κ-opioid receptor bound to the full Gi protein and the MP1104 agonist
- From the Cover
Amirhossein Mafi, Soo-Kyung Kim, and William A. Goddard IIIPNAS March 17, 2020 117 (11) 5836-5843; first published March 3, 2020. https://doi.org/10.1073/pnas.1910006117See companion article:
- You have accessAbrogation of prenucleation, transient oligomerization of the Huntingtin exon 1 protein by human profilin IAlberto Ceccon, Vitali Tugarinov, Rodolfo Ghirlando, and G. Marius ClorePNAS March 17, 2020 117 (11) 5844-5852; first published March 3, 2020. https://doi.org/10.1073/pnas.1922264117
- You have accessCas9 interrogates DNA in discrete steps modulated by mismatches and supercoilingIvan E. Ivanov, Addison V. Wright, Joshua C. Cofsky, Kevin D. Palacio Aris, Jennifer A. Doudna, and Zev BryantPNAS March 17, 2020 117 (11) 5853-5860; first published March 2, 2020. https://doi.org/10.1073/pnas.1913445117
- Open AccessCharge-dependent interactions of monomeric and filamentous actin with lipid bilayersCarsten F. E. Schroer, Lucia Baldauf, Lennard van Buren, Tsjerk A. Wassenaar, Manuel N. Melo, Gijsje H. Koenderink, and Siewert J. MarrinkPNAS March 17, 2020 117 (11) 5861-5872; first published March 2, 2020. https://doi.org/10.1073/pnas.1914884117
- Open AccessEpistatic contributions promote the unification of incompatible models of neutral molecular evolutionJose Alberto de la Paz, Charisse M. Nartey, Monisha Yuvaraj, and Faruck MorcosPNAS March 17, 2020 117 (11) 5873-5882; first published March 2, 2020. https://doi.org/10.1073/pnas.1913071117
See companion article:
- Open AccessTDP-43 α-helical structure tunes liquid–liquid phase separation and functionAlexander E. Conicella, Gregory L. Dignon, Gül H. Zerze, Hermann Broder Schmidt, Alexandra M. D’Ordine, Young C. Kim, Rajat Rohatgi, Yuna M. Ayala, Jeetain Mittal, and Nicolas L. FawziPNAS March 17, 2020 117 (11) 5883-5894; first published March 4, 2020. https://doi.org/10.1073/pnas.1912055117
- You have accessAn allosteric switch regulates Mycobacterium tuberculosis ClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMRSiavash Vahidi, Zev A. Ripstein, Jordan B. Juravsky, Enrico Rennella, Alfred L. Goldberg, Anthony K. Mittermaier, John L. Rubinstein, and Lewis E. KayPNAS March 17, 2020 117 (11) 5895-5906; first published March 2, 2020. https://doi.org/10.1073/pnas.1921630117
See companion article:
- Open AccessFrameshifting preserves key physicochemical properties of proteinsLukas Bartonek, Daniel Braun, and Bojan ZagrovicPNAS March 17, 2020 117 (11) 5907-5912; first published March 3, 2020. https://doi.org/10.1073/pnas.1911203117
Cell Biology
- You have accessTetraspanin-6 negatively regulates exosome productionRania Ghossoub, Marion Chéry, Stéphane Audebert, Raphael Leblanc, Antonio Luis Egea-Jimenez, Frédérique Lembo, Sarah Mammar, Flavien Le Dez, Luc Camoin, Jean-Paul Borg, Eric Rubinstein, Guido David, and Pascale ZimmermannPNAS March 17, 2020 117 (11) 5913-5922; first published February 27, 2020. https://doi.org/10.1073/pnas.1922447117
- You have accessCyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancerRushendhiran Kesavan, Timo Frömel, Sven Zukunft, Hebatullah Laban, Alexandra Geyer, Zumer Naeem, Juliana Heidler, Ilka Wittig, Eiman Elwakeel, Bernhard Brüne, Andreas Weigert, Rüdiger Popp, and Ingrid FlemingPNAS March 17, 2020 117 (11) 5923-5930; first published March 2, 2020. https://doi.org/10.1073/pnas.1921381117
- You have accessThe functional activity of E-cadherin controls tumor cell metastasis at multiple stepsTae-Young Na, Leslayann Schecterson, Alisha M. Mendonsa, and Barry M. GumbinerPNAS March 17, 2020 117 (11) 5931-5937; first published March 3, 2020. https://doi.org/10.1073/pnas.1918167117
Developmental Biology
- You have accessUnique reproductive strategy in the swamp wallabyBrandon R. Menzies, Thomas B. Hildebrandt, and Marilyn B. RenfreePNAS March 17, 2020 117 (11) 5938-5942; first published March 2, 2020. https://doi.org/10.1073/pnas.1922678117
Ecology
- Open AccessAlgal photophysiology drives darkening and melt of the Greenland Ice Sheet
- From the Cover
Christopher J. Williamson, Joseph Cook, Andrew Tedstone, Marian Yallop, Jenine McCutcheon, Ewa Poniecka, Douglas Campbell, Tristram Irvine-Fynn, James McQuaid, Martyn Tranter, Rupert Perkins, and Alexandre AnesioPNAS March 17, 2020 117 (11) 5694-5705; first published February 24, 2020. https://doi.org/10.1073/pnas.1918412117
Environmental Sciences
- Open AccessMicrobial evolutionary strategies in a dynamic oceanNathan G. Walworth, Emily J. Zakem, John P. Dunne, Sinéad Collins, and Naomi M. LevinePNAS March 17, 2020 117 (11) 5943-5948; first published March 2, 2020. https://doi.org/10.1073/pnas.1919332117
- Open AccessAssessing the role of live poultry trade in community-structured transmission of avian influenza in China
- From the Cover
Qiqi Yang, Xiang Zhao, Philippe Lemey, Marc A. Suchard, Yuhai Bi, Weifeng Shi, Di Liu, Wenbao Qi, Guogang Zhang, Nils Chr. Stenseth, Oliver G. Pybus, and Huaiyu TianPNAS March 17, 2020 117 (11) 5949-5954; first published March 2, 2020. https://doi.org/10.1073/pnas.1906954117
Evolution
- You have accessSympatric speciation of wild emmer wheat driven by ecology and chromosomal rearrangementsHongwei Wang, Huayan Yin, Chengzhi Jiao, Xiaojian Fang, Guiping Wang, Guangrong Li, Fei Ni, Penghuan Li, Peisen Su, Wenyang Ge, Zhongfan Lyu, Shoushen Xu, Yanhong Yang, Yongchao Hao, Xinxin Cheng, Jinxiao Zhao, Cheng Liu, Fengfeng Xu, Xin Ma, Silong Sun, Yan Zhao, Yinguang Bao, Cheng Liu, Jingjing Zhang, Tomas Pavlicek, Anfei Li, Zujun Yang, Eviatar Nevo, and Lingrang KongPNAS March 17, 2020 117 (11) 5955-5963; first published March 2, 2020. https://doi.org/10.1073/pnas.1920415117
- Open AccessDramatic dietary shift maintains sequestered toxins in chemically defended snakesTatsuya Yoshida, Rinako Ujiie, Alan H. Savitzky, Teppei Jono, Takato Inoue, Naoko Yoshinaga, Shunsuke Aburaya, Wataru Aoki, Hirohiko Takeuchi, Li Ding, Qin Chen, Chengquan Cao, Tein-Shun Tsai, Anslem de Silva, Dharshani Mahaulpatha, Tao Thien Nguyen, Yezhong Tang, Naoki Mori, and Akira MoriPNAS March 17, 2020 117 (11) 5964-5969; first published February 24, 2020. https://doi.org/10.1073/pnas.1919065117
- You have accessClonemate cotransmission supports a role for kin selection in a puppeteer parasiteCharles D. Criscione, Bradley J. van Paridon, John S. Gilleard, and Cameron P. GoaterPNAS March 17, 2020 117 (11) 5970-5976; first published March 2, 2020. https://doi.org/10.1073/pnas.1922272117
- You have accessIntegrated structural and evolutionary analysis reveals common mechanisms underlying adaptive evolution in mammalsGreg Slodkowicz and Nick GoldmanPNAS March 17, 2020 117 (11) 5977-5986; first published March 2, 2020. https://doi.org/10.1073/pnas.1916786117
Genetics
- Open AccessCaenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposonsSylvia E. J. Fischer and Gary RuvkunPNAS March 17, 2020 117 (11) 5987-5996; first published March 2, 2020. https://doi.org/10.1073/pnas.1919028117
- You have accessAssessing thyroid cancer risk using polygenic risk scoresSandya Liyanarachchi, Julius Gudmundsson, Egil Ferkingstad, Huiling He, Jon G. Jonasson, Vinicius Tragante, Folkert W. Asselbergs, Li Xu, Lambertus A. Kiemeney, Romana T. Netea-Maier, Jose I. Mayordomo, Theo S. Plantinga, Hannes Hjartarson, Jon Hrafnkelsson, Erich M. Sturgis, Pamela Brock, Fadi Nabhan, Gudmar Thorleifsson, Matthew D. Ringel, Kari Stefansson, and Albert de la ChapellePNAS March 17, 2020 117 (11) 5997-6002; first published March 4, 2020. https://doi.org/10.1073/pnas.1919976117
- Open AccessThe regulatory and transcriptional landscape associated with carbon utilization in a filamentous fungusVincent W. Wu, Nils Thieme, Lori B. Huberman, Axel Dietschmann, David J. Kowbel, Juna Lee, Sara Calhoun, Vasanth R. Singan, Anna Lipzen, Yi Xiong, Remo Monti, Matthew J. Blow, Ronan C. O’Malley, Igor V. Grigoriev, J. Philipp Benz, and N. Louise GlassPNAS March 17, 2020 117 (11) 6003-6013; first published February 28, 2020. https://doi.org/10.1073/pnas.1915611117
- You have accessSensory cilia as the Achilles heel of nematodes when attacked by carnivorous mushrooms
- From the Cover
Ching-Han Lee, Han-Wen Chang, Ching-Ting Yang, Niaz Wali, Jiun-Jie Shie, and Yen-Ping HsuehPNAS March 17, 2020 117 (11) 6014-6022; first published March 2, 2020. https://doi.org/10.1073/pnas.1918473117See companion article:
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- You have accessLoss-of-function BK channel mutation causes impaired mitochondria and progressive cerebellar ataxiaXiaofei Du, Joao L. Carvalho-de-Souza, Cenfu Wei, Willy Carrasquel-Ursulaez, Yenisleidy Lorenzo, Naileth Gonzalez, Tomoya Kubota, Julia Staisch, Timothy Hain, Natalie Petrossian, Michael Xu, Ramon Latorre, Francisco Bezanilla, and Christopher M. GomezPNAS March 17, 2020 117 (11) 6023-6034; first published March 4, 2020. https://doi.org/10.1073/pnas.1920008117
- Open AccessDNA polymerase δ proofreads errors made by DNA polymerase εChelsea R. Bulock, Xuanxuan Xing, and Polina V. ShcherbakovaPNAS March 17, 2020 117 (11) 6035-6041; first published March 2, 2020. https://doi.org/10.1073/pnas.1917624117
Immunology and Inflammation
- You have accessRegulatory CD8 T cells that recognize Qa-1 expressed by CD4 T-helper cells inhibit rejection of heart allograftsJohn Y. Choi, Siawosh K. Eskandari, Songjie Cai, Ina Sulkaj, Jean Pierre Assaker, Hazim Allos, Juliano AlHaddad, Saif A. Muhsin, Eman Alhussain, Amr Mansouri, Melissa Y. Yeung, Marc A. J. Seelen, Hye-Jung Kim, Harvey Cantor, and Jamil R. AzziPNAS March 17, 2020 117 (11) 6042-6046; first published February 28, 2020. https://doi.org/10.1073/pnas.1918950117
- You have accessLactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunityDalton Hermans, Sanjivan Gautam, Juan C. García-Cañaveras, Daniel Gromer, Suman Mitra, Rosanne Spolski, Peng Li, Stephen Christensen, Rosa Nguyen, Jian-Xin Lin, Jangsuk Oh, Ning Du, Sharon Veenbergen, Jessica Fioravanti, Risa Ebina-Shibuya, Christopher Bleck, Leonard M. Neckers, Joshua D. Rabinowitz, Luca Gattinoni, and Warren J. LeonardPNAS March 17, 2020 117 (11) 6047-6055; first published March 2, 2020. https://doi.org/10.1073/pnas.1920413117
- Open AccessHistone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolismAdam P. Cribbs, Stefan Terlecki-Zaniewicz, Martin Philpott, Jeroen Baardman, David Ahern, Morten Lindow, Susanna Obad, Henrik Oerum, Brante Sampey, Palwinder K. Mander, Henry Penn, Paul Wordsworth, Paul Bowness, Menno de Winther, Rab K. Prinjha, Marc Feldmann, and Udo OppermannPNAS March 17, 2020 117 (11) 6056-6066; first published March 2, 2020. https://doi.org/10.1073/pnas.1919893117
- You have accessSignaling mechanisms of growth hormone-releasing hormone receptor in LPS-induced acute ocular inflammationWei Cheng Liang, Jia Lin Ren, Qiu Xiao Yu, Jian Li, Tsz Kin Ng, Wai Kit Chu, Yong Jie Qin, Kai On Chu, Andrew V. Schally, Chi Pui Pang, and Sun On ChanPNAS March 17, 2020 117 (11) 6067-6074; first published March 2, 2020. https://doi.org/10.1073/pnas.1904532117
Medical Sciences
- Open AccessAbrogation of esophageal carcinoma development in miR-31 knockout ratsLouise Y. Fong, Cristian Taccioli, Alexey Palamarchuk, Guidantonio Malagoli Tagliazucchi, Ruiyan Jing, Karl J. Smalley, Sili Fan, Joseph Altemus, Oliver Fiehn, Kay Huebner, John L. Farber, and Carlo M. CrocePNAS March 17, 2020 117 (11) 6075-6085; first published March 2, 2020. https://doi.org/10.1073/pnas.1920333117
- You have accessImmunotoxin SS1P is rapidly removed by proximal tubule cells of kidney, whose damage contributes to albumin loss in urineXui-Fen Liu, Junxia Wei, Qi Zhou, Bruce A. Molitoris, Ruben Sandoval, Hisataka Kobayashi, Ryuhei Okada, Tadanobu Nagaya, Baktiar Karim, Donna Butcher, and Ira PastanPNAS March 17, 2020 117 (11) 6086-6091; first published March 2, 2020. https://doi.org/10.1073/pnas.1919038117
- You have accessRegulation of B cell receptor-dependent NF-κB signaling by the tumor suppressor KLHL14Jaewoo Choi, James D. Phelan, George W. Wright, Björn Häupl, Da Wei Huang, Arthur L. Shaffer III, Ryan M. Young, Zhuo Wang, Hong Zhao, Xin Yu, Thomas Oellerich, and Louis M. StaudtPNAS March 17, 2020 117 (11) 6092-6102; first published March 3, 2020. https://doi.org/10.1073/pnas.1921187117
- You have accessA hepatocyte differentiation model reveals two subtypes of liver cancer with different oncofetal properties and therapeutic targetsMing Liu, Qian Yan, Yi Sun, Yoonhee Nam, Liang Hu, Jane HC Loong, Qi Ouyang, Yu Zhang, Hao-Long Li, Fan-En Kong, Lei Li, Yan Li, Mei-Mei Li, Wei Cheng, Ling-Xi Jiang, Shuo Fang, Xiao-Dong Yang, Jia-Qiang Mo, Yuan-Feng Gong, Yun-Qiang Tang, Yan Li, Yun-Fei Yuan, Ning-Fang Ma, Ge Lin, Stephanie Ma, Ji-Guang Wang, and Xin-Yuan GuanPNAS March 17, 2020 117 (11) 6103-6113; first published March 2, 2020. https://doi.org/10.1073/pnas.1912146117
Microbiology
- You have accessBiphasic chemotaxis of Escherichia coli to the microbiota metabolite indoleJingyun Yang, Ravi Chawla, Kathy Y. Rhee, Rachit Gupta, Michael D. Manson, Arul Jayaraman, and Pushkar P. LelePNAS March 17, 2020 117 (11) 6114-6120; first published March 2, 2020. https://doi.org/10.1073/pnas.1916974117
- You have accessCell-penetrating peptide inhibits retromer-mediated human papillomavirus trafficking during virus entryPengwei Zhang, Ruben Moreno, Paul F. Lambert, and Daniel DiMaioPNAS March 17, 2020 117 (11) 6121-6128; first published March 2, 2020. https://doi.org/10.1073/pnas.1917748117
- Open AccessClass A PBPs have a distinct and unique role in the construction of the pneumococcal cell wallDaniel Straume, Katarzyna Wiaroslawa Piechowiak, Silje Olsen, Gro Anita Stamsås, Kari Helene Berg, Morten Kjos, Maria Victoria Heggenhougen, Martín Alcorlo, Juan A. Hermoso, and Leiv Sigve HåvarsteinPNAS March 17, 2020 117 (11) 6129-6138; first published March 2, 2020. https://doi.org/10.1073/pnas.1917820117
- You have accessStructural elucidation of the Clostridioides difficile transferase toxin reveals a single-site binding mode for the enzymeMichael J. Sheedlo, David M. Anderson, Audrey K. Thomas, and D. Borden LacyPNAS March 17, 2020 117 (11) 6139-6144; first published March 2, 2020. https://doi.org/10.1073/pnas.1920555117
- You have accessVisualizing the translation and packaging of HIV-1 full-length RNAJianbo Chen, Yang Liu, Bin Wu, Olga A. Nikolaitchik, Preeti R. Mohan, Jiji Chen, Vinay K. Pathak, and Wei-Shau HuPNAS March 17, 2020 117 (11) 6145-6155; first published March 4, 2020. https://doi.org/10.1073/pnas.1917590117
Neuroscience
- Open AccessThe neural signature of numerosity by separating numerical and continuous magnitude extraction in visual cortex with frequency-tagged EEGAmandine Van Rinsveld, Mathieu Guillaume, Peter J. Kohler, Christine Schiltz, Wim Gevers, and Alain ContentPNAS March 17, 2020 117 (11) 5726-5732; first published March 2, 2020. https://doi.org/10.1073/pnas.1917849117
- Open AccessActive efficient coding explains the development of binocular vision and its failure in amblyopiaSamuel Eckmann, Lukas Klimmasch, Bertram E. Shi, and Jochen TrieschPNAS March 17, 2020 117 (11) 6156-6162; first published March 2, 2020. https://doi.org/10.1073/pnas.1908100117
- You have accessConnectivity at the origins of domain specificity in the cortical face and place networksFrederik S. Kamps, Cassandra L. Hendrix, Patricia A. Brennan, and Daniel D. DilksPNAS March 17, 2020 117 (11) 6163-6169; first published March 2, 2020. https://doi.org/10.1073/pnas.1911359117
- Open AccessDiet modulates brain network stability, a biomarker for brain aging, in young adultsLilianne R. Mujica-Parodi, Anar Amgalan, Syed Fahad Sultan, Botond Antal, Xiaofei Sun, Steven Skiena, Andrew Lithen, Noor Adra, Eva-Maria Ratai, Corey Weistuch, Sindhuja Tirumalai Govindarajan, Helmut H. Strey, Ken A. Dill, Steven M. Stufflebeam, Richard L. Veech, and Kieran ClarkePNAS March 17, 2020 117 (11) 6170-6177; first published March 3, 2020. https://doi.org/10.1073/pnas.1913042117
- Open AccessContext-dependent operation of neural circuits underlies a navigation behavior in Caenorhabditis elegansMuneki Ikeda, Shunji Nakano, Andrew C. Giles, Linghuan Xu, Wagner Steuer Costa, Alexander Gottschalk, and Ikue MoriPNAS March 17, 2020 117 (11) 6178-6188; first published March 2, 2020. https://doi.org/10.1073/pnas.1918528117
- You have accessNf1 deletion results in depletion of the Lhx6 transcription factor and a specific loss of parvalbumin+ cortical interneuronsKartik Angara, Emily Ling-Lin Pai, Stephanie M. Bilinovich, April M. Stafford, Julie T. Nguyen, Katie X. Li, Anirban Paul, John L. Rubenstein, and Daniel VogtPNAS March 17, 2020 117 (11) 6189-6195; first published March 2, 2020. https://doi.org/10.1073/pnas.1915458117
- Open AccessAnterior cingulate cortex is necessary for adaptation of action plansAdam T. Brockett, Stephen S. Tennyson, Coreylyn A. deBettencourt, Fatou Gaye, and Matthew R. RoeschPNAS March 17, 2020 117 (11) 6196-6204; first published March 4, 2020. https://doi.org/10.1073/pnas.1919303117
Plant Biology
- You have accessCUL3BPM E3 ubiquitin ligases regulate MYC2, MYC3, and MYC4 stability and JA responsesJose Manuel Chico, Esther Lechner, Gemma Fernandez-Barbero, Esther Canibano, Gloria García-Casado, Jose Manuel Franco-Zorrilla, Philippe Hammann, Angel M. Zamarreño, Jose M. García-Mina, Vicente Rubio, Pascal Genschik, and Roberto SolanoPNAS March 17, 2020 117 (11) 6205-6215; first published March 2, 2020. https://doi.org/10.1073/pnas.1912199117
- You have accessTriacylglycerol and phytyl ester synthesis in Synechocystis sp. PCC6803Mohammed Aizouq, Helga Peisker, Katharina Gutbrod, Michael Melzer, Georg Hölzl, and Peter DörmannPNAS March 17, 2020 117 (11) 6216-6222; first published March 2, 2020. https://doi.org/10.1073/pnas.1915930117
- Open AccessCarbon export from leaves is controlled via ubiquitination and phosphorylation of sucrose transporter SUC2
- From the Cover
Qiyu Xu, Shijiao Yin, Yue Ma, Min Song, Yingjie Song, Shuaicheng Mu, Yunsong Li, Xiaohui Liu, Yunjuan Ren, Chen Gao, Shaolin Chen, and Johannes LieschePNAS March 17, 2020 117 (11) 6223-6230; first published March 2, 2020. https://doi.org/10.1073/pnas.1912754117See companion article:
- You have accessTranscriptional repression specifies the central cell for double fertilizationMeng-Xia Zhang, Shan-Shan Zhu, Yong-Chao Xu, Ya-Long Guo, Wei-Cai Yang, and Hong-Ju LiPNAS March 17, 2020 117 (11) 6231-6236; first published March 4, 2020. https://doi.org/10.1073/pnas.1909465117
- Open AccessRegulation of stomatal development by stomatal lineage miRNAsJiali Zhu, Ji-Hwan Park, Seulbee Lee, Jae Ho Lee, Daehee Hwang, June M. Kwak, and Yun Ju KimPNAS March 17, 2020 117 (11) 6237-6245; first published March 2, 2020. https://doi.org/10.1073/pnas.1919722117
Psychological and Cognitive Sciences
- You have accessEye movements support behavioral pattern completionJordana S. Wynn, Jennifer D. Ryan, and Bradley R. BuchsbaumPNAS March 17, 2020 117 (11) 6246-6254; first published March 2, 2020. https://doi.org/10.1073/pnas.1917586117
- You have accessSpeakers are able to categorize vowels based on tongue somatosensationJean-François Patri, David J. Ostry, Julien Diard, Jean-Luc Schwartz, Pamela Trudeau-Fisette, Christophe Savariaux, and Pascal PerrierPNAS March 17, 2020 117 (11) 6255-6263; first published March 2, 2020. https://doi.org/10.1073/pnas.1911142117
Systems Biology
- Open AccessMetabolic and genetic basis for auxotrophies in Gram-negative speciesYara Seif, Kumari Sonal Choudhary, Ying Hefner, Amitesh Anand, Laurence Yang, and Bernhard O. PalssonPNAS March 17, 2020 117 (11) 6264-6273; first published March 4, 2020. https://doi.org/10.1073/pnas.1910499117
Corrections
- You have accessCorrection for Shi et al., Deep elastic strain engineering of bandgap through machine learningPNAS March 17, 2020 117 (11) 6274; first published March 9, 2020. https://doi.org/10.1073/pnas.2002727117
- You have accessCorrection for Kovalev et al., High-resolution structural insights into the heliorhodopsin familyPNAS March 17, 2020 117 (11) 6275; first published March 16, 2020. https://doi.org/10.1073/pnas.2003117117
- You have accessCorrection for Hsu et al., Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migrationPNAS March 17, 2020 117 (11) 6276; first published March 9, 2020. https://doi.org/10.1073/pnas.2003198117
- You have accessCorrection for Cristopher Bragg et al., Disease onset in X-linked dystonia-parkinsonism correlates with expansion of a hexameric repeat within an SVA retrotransposon in TAF1PNAS March 17, 2020 117 (11) 6277; first published March 9, 2020. https://doi.org/10.1073/pnas.2003190117
Commentaries
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