Proceedings of the National Academy of Sciences: 117 (11)

New Research In

March 17, 2020; vol. 117 no. 11

This Week in PNAS

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In This Issue
PNAS March 17, 2020 117 (11) 5545-5546; https://doi.org/10.1073/iti1120117

Inner Workings

An over-the-shoulder look at scientists at work.

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Inner Workings: Understanding the evolution of cell types to explain the roots of animal diversity
Front Matter
Viviane Callier

PNAS March 17, 2020 117 (11) 5547-5549; https://doi.org/10.1073/pnas.2002403117

Commentaries

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Histamine provides an original vista on cardiorenal syndrome
Pierre-Louis Tharaux

PNAS March 17, 2020 117 (11) 5550-5552; first published March 2, 2020. https://doi.org/10.1073/pnas.2001336117
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Do the social roles that women and men occupy in science allow equal access to publication?
Alice H. Eagly

PNAS March 17, 2020 117 (11) 5553-5555; first published March 3, 2020. https://doi.org/10.1073/pnas.2001684117
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Late-life costs of raising sons in bighorn sheep
Hannah Froy and Marlène Gamelon

PNAS March 17, 2020 117 (11) 5556-5558; first published February 25, 2020. https://doi.org/10.1073/pnas.2001659117
See companion article:
Sons accelerate maternal aging in a wild mammal
- Feb 18, 2020

Perspective

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Science is not a signal detection problem
Brent M. Wilson, Christine R. Harris, and John T. Wixted

PNAS March 17, 2020 117 (11) 5559-5567; first published March 3, 2020. https://doi.org/10.1073/pnas.1914237117

Letters

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Complex “human−vegetation−climate” interactions in the Late Holocene and their significance for paleotemperature reconstructions
Yunxia Li, Yiping Tian, Haichun Guo, Shikai Wei, Jiantao Cao, Chao Huang, Fuxi Shi, and Zhiguo Rao

PNAS March 17, 2020 117 (11) 5568-5570; first published February 21, 2020. https://doi.org/10.1073/pnas.1922325117
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Reply to Li et al.: Human societies began to play a significant role in global sediment transfer 4,000 years ago
Jean-Philippe Jenny, Sujan Koirala, Irene Gregory-Eaves, Pierre Francus, Bernhard Ahrens, Victor Brovkin, Antti E. K. Ojala, Bernd Zolitschka, Juergen Bader, and Nuno Carvalhais

PNAS March 17, 2020 117 (11) 5571-5572; first published February 21, 2020. https://doi.org/10.1073/pnas.1922723117
See companion article:
Human and climate global-scale imprint on sediment transfer during the Holocene
- Oct 28, 2019
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Apes, adaptations, and artifacts of anesthetics
Bjarke Jensen and Tobias Wang

PNAS March 17, 2020 117 (11) 5573; first published February 20, 2020. https://doi.org/10.1073/pnas.1921494117
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Reply to Jensen and Wang: Chimpanzees under pressure—Selection of a left ventricular structural and functional phenotype
Robert E. Shave, Daniel E. Lieberman, Aimee L. Drane, and Aaron L. Baggish

PNAS March 17, 2020 117 (11) 5574-5575; first published February 20, 2020. https://doi.org/10.1073/pnas.1922202117
See companion article:
Selection of endurance capabilities and the trade-off between pressure and volume in the evolution of the human heart
- Sep 16, 2019

Physical Sciences

Applied Physical Sciences
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  Possibility for inhibited spontaneous emission in electromagnetically open parity–time-symmetric guiding structures
  Yakir Hadad and Nader Engheta
  
  PNAS March 17, 2020 117 (11) 5576-5581; first published March 2, 2020. https://doi.org/10.1073/pnas.1914279117
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  Coherent phonon dynamics in spatially separated graphene mechanical resonators
  Zhuo-Zhi Zhang, Xiang-Xiang Song, Gang Luo, Zi-Jia Su, Kai-Long Wang, Gang Cao, Hai-Ou Li, Ming Xiao, Guang-Can Guo, Lin Tian, Guang-Wei Deng, and Guo-Ping Guo
  
  PNAS March 17, 2020 117 (11) 5582-5587; first published March 2, 2020. https://doi.org/10.1073/pnas.1916978117
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  In situ healing of dendrites in a potassium metal battery
  Prateek Hundekar, Swastik Basu, Xiulin Fan, Lu Li, Anthony Yoshimura, Tushar Gupta, Varun Sarbada, Aniruddha Lakhnot, Rishabh Jain, Shankar Narayanan, Yunfeng Shi, Chunsheng Wang, and Nikhil Koratkar
  
  PNAS March 17, 2020 117 (11) 5588-5594; first published March 2, 2020. https://doi.org/10.1073/pnas.1915470117
Biophysics and Computational Biology
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  Investigations of the underlying mechanisms of HIF-1α and CITED2 binding to TAZ1
  Wen-Ting Chu, Xiakun Chu, and Jin Wang
  
  PNAS March 17, 2020 117 (11) 5595-5603; first published March 2, 2020. https://doi.org/10.1073/pnas.1915333117
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  Active volume regulation in adhered cells
  Ram M. Adar and Samuel A. Safran
  
  PNAS March 17, 2020 117 (11) 5604-5609; first published March 4, 2020. https://doi.org/10.1073/pnas.1918203117
- You have access
  The atomistic level structure for the activated human κ-opioid receptor bound to the full Gi protein and the MP1104 agonist
  From the Cover
  
  Amirhossein Mafi, Soo-Kyung Kim, and William A. Goddard III
  
  PNAS March 17, 2020 117 (11) 5836-5843; first published March 3, 2020. https://doi.org/10.1073/pnas.1910006117
  
  See companion article:
  The quest for high-resolution G protein-coupled receptor–G protein structures
  - Mar 16, 2020
  
  The quest for high-resolution G protein-coupled receptor–G protein structures
  - Mar 16, 2020
- You have access
  Abrogation of prenucleation, transient oligomerization of the Huntingtin exon 1 protein by human profilin I
  Alberto Ceccon, Vitali Tugarinov, Rodolfo Ghirlando, and G. Marius Clore
  
  PNAS March 17, 2020 117 (11) 5844-5852; first published March 3, 2020. https://doi.org/10.1073/pnas.1922264117
- You have access
  Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
  Ivan E. Ivanov, Addison V. Wright, Joshua C. Cofsky, Kevin D. Palacio Aris, Jennifer A. Doudna, and Zev Bryant
  
  PNAS March 17, 2020 117 (11) 5853-5860; first published March 2, 2020. https://doi.org/10.1073/pnas.1913445117
- Open Access
  Charge-dependent interactions of monomeric and filamentous actin with lipid bilayers
  Carsten F. E. Schroer, Lucia Baldauf, Lennard van Buren, Tsjerk A. Wassenaar, Manuel N. Melo, Gijsje H. Koenderink, and Siewert J. Marrink
  
  PNAS March 17, 2020 117 (11) 5861-5872; first published March 2, 2020. https://doi.org/10.1073/pnas.1914884117
- Open Access
  Active efficient coding explains the development of binocular vision and its failure in amblyopia
  Samuel Eckmann, Lukas Klimmasch, Bertram E. Shi, and Jochen Triesch
  
  PNAS March 17, 2020 117 (11) 6156-6162; first published March 2, 2020. https://doi.org/10.1073/pnas.1908100117
Chemistry
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  Association of Cl with C₂H₂ by unified variable-reaction-coordinate and reaction-path variational transition-state theory
  Linyao Zhang, Donald G. Truhlar, and Shaozeng Sun
  
  PNAS March 17, 2020 117 (11) 5610-5616; first published March 2, 2020. https://doi.org/10.1073/pnas.1920018117
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  Programming colloidal bonding using DNA strand-displacement circuitry
  Xiang Zhou, Dongbao Yao, Wenqiang Hua, Ningdong Huang, Xiaowei Chen, Liangbin Li, Miao He, Yunhan Zhang, Yijun Guo, Shiyan Xiao, Fenggang Bian, and Haojun Liang
  
  PNAS March 17, 2020 117 (11) 5617-5623; first published March 4, 2020. https://doi.org/10.1073/pnas.1917941117
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  Systematic identification of engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugation
  Susanna K. Elledge, Hai L. Tran, Alec H. Christian, Veronica Steri, Byron Hann, F. Dean Toste, Christopher J. Chang, and James A. Wells
  
  PNAS March 17, 2020 117 (11) 5733-5740; first published March 2, 2020. https://doi.org/10.1073/pnas.1920561117
Computer Sciences
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  Communication cost of consensus for nodes with limited memory
  Giulia Fanti, Nina Holden, Yuval Peres, and Gireeja Ranade
  
  PNAS March 17, 2020 117 (11) 5624-5630; first published March 4, 2020. https://doi.org/10.1073/pnas.1912980117
- Open Access
  The impossibility of low-rank representations for triangle-rich complex networks
  C. Seshadhri, Aneesh Sharma, Andrew Stolman, and Ashish Goel
  
  PNAS March 17, 2020 117 (11) 5631-5637; first published March 2, 2020. https://doi.org/10.1073/pnas.1911030117
Earth, Atmospheric, and Planetary Sciences
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  Stability of H₃O at extreme conditions and implications for the magnetic fields of Uranus and Neptune
  Peihao Huang, Hanyu Liu, Jian Lv, Quan Li, Chunhong Long, Yanchao Wang, Changfeng Chen, Russell J. Hemley, and Yanming Ma
  
  PNAS March 17, 2020 117 (11) 5638-5643; first published March 3, 2020. https://doi.org/10.1073/pnas.1921811117
- Open Access
  Microbial evolutionary strategies in a dynamic ocean
  Nathan G. Walworth, Emily J. Zakem, John P. Dunne, Sinéad Collins, and Naomi M. Levine
  
  PNAS March 17, 2020 117 (11) 5943-5948; first published March 2, 2020. https://doi.org/10.1073/pnas.1919332117
Engineering
- Open Access
  Sonoselective transfection of cerebral vasculature without blood–brain barrier disruption
  Catherine M. Gorick, Alexander S. Mathew, William J. Garrison, E. Andrew Thim, Delaney G. Fisher, Caitleen A. Copeland, Ji Song, Alexander L. Klibanov, G. Wilson Miller, and Richard J. Price
  
  PNAS March 17, 2020 117 (11) 5644-5654; first published March 2, 2020. https://doi.org/10.1073/pnas.1914595117
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  Mechanophenotyping of 3D multicellular clusters using displacement arrays of rendered tractions
  Susan E. Leggett, Mohak Patel, Thomas M. Valentin, Lena Gamboa, Amanda S. Khoo, Evelyn Kendall Williams, Christian Franck, and Ian Y. Wong
  
  PNAS March 17, 2020 117 (11) 5655-5663; first published March 2, 2020. https://doi.org/10.1073/pnas.1918296117
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  The effects of evolutionary adaptations on spreading processes in complex networks
  Rashad Eletreby, Yong Zhuang, Kathleen M. Carley, Osman Yağan, and H. Vincent Poor
  
  PNAS March 17, 2020 117 (11) 5664-5670; first published March 2, 2020. https://doi.org/10.1073/pnas.1918529117
- Open Access
  Embedded droplet printing in yield-stress fluids
  Arif Z. Nelson, Binu Kundukad, Wai Kuan Wong, Saif A. Khan, and Patrick S. Doyle
  
  PNAS March 17, 2020 117 (11) 5671-5679; first published March 3, 2020. https://doi.org/10.1073/pnas.1919363117
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  Hierarchically porous Au nanostructures with interconnected channels for efficient mass transport in electrocatalytic CO₂ reduction
  Gayea Hyun, Jun Tae Song, Changui Ahn, Youngjin Ham, Donghwi Cho, Jihun Oh, and Seokwoo Jeon
  
  PNAS March 17, 2020 117 (11) 5680-5685; first published March 4, 2020. https://doi.org/10.1073/pnas.1918837117
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  Extreme mechanical resilience of self-assembled nanolabyrinthine materials
  Carlos M. Portela, A. Vidyasagar, Sebastian Krödel, Tamara Weissenbach, Daryl W. Yee, Julia R. Greer, and Dennis M. Kochmann
  
  PNAS March 17, 2020 117 (11) 5686-5693; first published March 4, 2020. https://doi.org/10.1073/pnas.1916817117
Environmental Sciences
- Open Access
  Algal photophysiology drives darkening and melt of the Greenland Ice Sheet
  From the Cover
  
  Christopher J. Williamson, Joseph Cook, Andrew Tedstone, Marian Yallop, Jenine McCutcheon, Ewa Poniecka, Douglas Campbell, Tristram Irvine-Fynn, James McQuaid, Martyn Tranter, Rupert Perkins, and Alexandre Anesio
  
  PNAS March 17, 2020 117 (11) 5694-5705; first published February 24, 2020. https://doi.org/10.1073/pnas.1918412117
Physics
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  Topological transition in measurement-induced geometric phases
  Valentin Gebhart, Kyrylo Snizhko, Thomas Wellens, Andreas Buchleitner, Alessandro Romito, and Yuval Gefen
  
  PNAS March 17, 2020 117 (11) 5706-5713; first published March 2, 2020. https://doi.org/10.1073/pnas.1911620117
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  Experimental observation of the marginal glass phase in a colloidal glass
  Andrew P. Hammond and Eric I. Corwin
  
  PNAS March 17, 2020 117 (11) 5714-5718; first published March 3, 2020. https://doi.org/10.1073/pnas.1917283117

Biological Sciences

Applied Biological Sciences
- Open Access
  Sonoselective transfection of cerebral vasculature without blood–brain barrier disruption
  Catherine M. Gorick, Alexander S. Mathew, William J. Garrison, E. Andrew Thim, Delaney G. Fisher, Caitleen A. Copeland, Ji Song, Alexander L. Klibanov, G. Wilson Miller, and Richard J. Price
  
  PNAS March 17, 2020 117 (11) 5644-5654; first published March 2, 2020. https://doi.org/10.1073/pnas.1914595117
Biochemistry
- You have access
  Systematic identification of engineered methionines and oxaziridines for efficient, stable, and site-specific antibody bioconjugation
  Susanna K. Elledge, Hai L. Tran, Alec H. Christian, Veronica Steri, Byron Hann, F. Dean Toste, Christopher J. Chang, and James A. Wells
  
  PNAS March 17, 2020 117 (11) 5733-5740; first published March 2, 2020. https://doi.org/10.1073/pnas.1920561117
- Open Access
  In vitro selection of ribozyme ligases that use prebiotically plausible 2-aminoimidazole–activated substrates
  Travis Walton, Saurja DasGupta, Daniel Duzdevich, Seung Soo Oh, and Jack W. Szostak
  
  PNAS March 17, 2020 117 (11) 5741-5748; first published March 2, 2020. https://doi.org/10.1073/pnas.1914367117
- Open Access
  Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism
  Eylan Yutuc, Roberto Angelini, Mark Baumert, Natalia Mast, Irina Pikuleva, Jillian Newton, Malcolm R. Clench, David O. F. Skibinski, Owain W. Howell, Yuqin Wang, and William J. Griffiths
  
  PNAS March 17, 2020 117 (11) 5749-5760; first published March 4, 2020. https://doi.org/10.1073/pnas.1917421117
- Open Access
  Circadian control of interferon-sensitive gene expression in murine skin
  Elyse Noelani Greenberg, Michaela Ellen Marshall, Suoqin Jin, Sanan Venkatesh, Morgan Dragan, Lam C. Tsoi, Johann E. Gudjonsson, Qing Nie, Joseph S. Takahashi, and Bogi Andersen
  
  PNAS March 17, 2020 117 (11) 5761-5771; first published March 4, 2020. https://doi.org/10.1073/pnas.1915773117
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  Conformational control of small GTPases by AMPylation
  Katja Barthelmes, Evelyn Ramcke, Hyun-Seo Kang, Michael Sattler, and Aymelt Itzen
  
  PNAS March 17, 2020 117 (11) 5772-5781; first published March 2, 2020. https://doi.org/10.1073/pnas.1917549117
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  SOX4-mediated repression of specific tRNAs inhibits proliferation of human glioblastoma cells
  Jianjing Yang, Derek K. Smith, Haoqi Ni, Ke Wu, Dongdong Huang, Sishi Pan, Adwait A. Sathe, Yu Tang, Meng-Lu Liu, Chao Xing, Chun-Li Zhang, and Qichuan Zhuge
  
  PNAS March 17, 2020 117 (11) 5782-5790; first published March 2, 2020. https://doi.org/10.1073/pnas.1920200117
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  bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA)
  Shuhui Lim, Regina Khoo, Khong Ming Peh, Jinkai Teo, Shih Chieh Chang, Simon Ng, Greg L. Beilhartz, Roman A. Melnyk, Charles W. Johannes, Christopher J. Brown, David P. Lane, Brian Henry, and Anthony W. Partridge
  
  PNAS March 17, 2020 117 (11) 5791-5800; first published March 2, 2020. https://doi.org/10.1073/pnas.1920251117
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  RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription
  Lingting Li, Vadim Molodtsov, Wei Lin, Richard H. Ebright, and Yu Zhang
  
  PNAS March 17, 2020 117 (11) 5801-5809; first published March 3, 2020. https://doi.org/10.1073/pnas.1920747117
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  Plasmodium chaperonin TRiC/CCT identified as a target of the antihistamine clemastine using parallel chemoproteomic strategy
  Kuan-Yi Lu, Baiyi Quan, Kayla Sylvester, Tamanna Srivastava, Michael C. Fitzgerald, and Emily R. Derbyshire
  
  PNAS March 17, 2020 117 (11) 5810-5817; first published March 3, 2020. https://doi.org/10.1073/pnas.1913525117
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  Mechanism of proton transfer in class A β-lactamase catalysis and inhibition by avibactam
  Orville A. Pemberton, Radwan E. Noor, Vasantha Kumar M. V., Ruslan Sanishvili, M. Trent Kemp, Fiona L. Kearns, H. Lee Woodcock, Ioannis Gelis, and Yu Chen
  
  PNAS March 17, 2020 117 (11) 5818-5825; first published March 2, 2020. https://doi.org/10.1073/pnas.1922203117
- Open Access
  Composition-based prediction and rational manipulation of prion-like domain recruitment to stress granules
  Amy E. Boncella, Jenifer E. Shattuck, Sean M. Cascarina, Kacy R. Paul, Matthew H. Baer, Anastasia Fomicheva, Andrew K. Lamb, and Eric D. Ross
  
  PNAS March 17, 2020 117 (11) 5826-5835; first published March 3, 2020. https://doi.org/10.1073/pnas.1912723117
Biophysics and Computational Biology
- You have access
  Investigations of the underlying mechanisms of HIF-1α and CITED2 binding to TAZ1
  Wen-Ting Chu, Xiakun Chu, and Jin Wang
  
  PNAS March 17, 2020 117 (11) 5595-5603; first published March 2, 2020. https://doi.org/10.1073/pnas.1915333117
- You have access
  Mechanophenotyping of 3D multicellular clusters using displacement arrays of rendered tractions
  Susan E. Leggett, Mohak Patel, Thomas M. Valentin, Lena Gamboa, Amanda S. Khoo, Evelyn Kendall Williams, Christian Franck, and Ian Y. Wong
  
  PNAS March 17, 2020 117 (11) 5655-5663; first published March 2, 2020. https://doi.org/10.1073/pnas.1918296117
- You have access
  The atomistic level structure for the activated human κ-opioid receptor bound to the full Gi protein and the MP1104 agonist
  From the Cover
  
  Amirhossein Mafi, Soo-Kyung Kim, and William A. Goddard III
  
  PNAS March 17, 2020 117 (11) 5836-5843; first published March 3, 2020. https://doi.org/10.1073/pnas.1910006117
  
  See companion article:
  The quest for high-resolution G protein-coupled receptor–G protein structures
  - Mar 16, 2020
  
  The quest for high-resolution G protein-coupled receptor–G protein structures
  - Mar 16, 2020
- You have access
  Abrogation of prenucleation, transient oligomerization of the Huntingtin exon 1 protein by human profilin I
  Alberto Ceccon, Vitali Tugarinov, Rodolfo Ghirlando, and G. Marius Clore
  
  PNAS March 17, 2020 117 (11) 5844-5852; first published March 3, 2020. https://doi.org/10.1073/pnas.1922264117
- You have access
  Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
  Ivan E. Ivanov, Addison V. Wright, Joshua C. Cofsky, Kevin D. Palacio Aris, Jennifer A. Doudna, and Zev Bryant
  
  PNAS March 17, 2020 117 (11) 5853-5860; first published March 2, 2020. https://doi.org/10.1073/pnas.1913445117
- Open Access
  Charge-dependent interactions of monomeric and filamentous actin with lipid bilayers
  Carsten F. E. Schroer, Lucia Baldauf, Lennard van Buren, Tsjerk A. Wassenaar, Manuel N. Melo, Gijsje H. Koenderink, and Siewert J. Marrink
  
  PNAS March 17, 2020 117 (11) 5861-5872; first published March 2, 2020. https://doi.org/10.1073/pnas.1914884117
- Open Access
  Epistatic contributions promote the unification of incompatible models of neutral molecular evolution
  Jose Alberto de la Paz, Charisse M. Nartey, Monisha Yuvaraj, and Faruck Morcos
  
  PNAS March 17, 2020 117 (11) 5873-5882; first published March 2, 2020. https://doi.org/10.1073/pnas.1913071117
- Open Access
  TDP-43 α-helical structure tunes liquid–liquid phase separation and function
  Alexander E. Conicella, Gregory L. Dignon, Gül H. Zerze, Hermann Broder Schmidt, Alexandra M. D’Ordine, Young C. Kim, Rajat Rohatgi, Yuna M. Ayala, Jeetain Mittal, and Nicolas L. Fawzi
  
  PNAS March 17, 2020 117 (11) 5883-5894; first published March 4, 2020. https://doi.org/10.1073/pnas.1912055117
- You have access
  An allosteric switch regulates Mycobacterium tuberculosis ClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR
  Siavash Vahidi, Zev A. Ripstein, Jordan B. Juravsky, Enrico Rennella, Alfred L. Goldberg, Anthony K. Mittermaier, John L. Rubinstein, and Lewis E. Kay
  
  PNAS March 17, 2020 117 (11) 5895-5906; first published March 2, 2020. https://doi.org/10.1073/pnas.1921630117
- Open Access
  Frameshifting preserves key physicochemical properties of proteins
  Lukas Bartonek, Daniel Braun, and Bojan Zagrovic
  
  PNAS March 17, 2020 117 (11) 5907-5912; first published March 3, 2020. https://doi.org/10.1073/pnas.1911203117
Cell Biology
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  Tetraspanin-6 negatively regulates exosome production
  Rania Ghossoub, Marion Chéry, Stéphane Audebert, Raphael Leblanc, Antonio Luis Egea-Jimenez, Frédérique Lembo, Sarah Mammar, Flavien Le Dez, Luc Camoin, Jean-Paul Borg, Eric Rubinstein, Guido David, and Pascale Zimmermann
  
  PNAS March 17, 2020 117 (11) 5913-5922; first published February 27, 2020. https://doi.org/10.1073/pnas.1922447117
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  Cyp2c44 regulates prostaglandin synthesis, lymphangiogenesis, and metastasis in a mouse model of breast cancer
  Rushendhiran Kesavan, Timo Frömel, Sven Zukunft, Hebatullah Laban, Alexandra Geyer, Zumer Naeem, Juliana Heidler, Ilka Wittig, Eiman Elwakeel, Bernhard Brüne, Andreas Weigert, Rüdiger Popp, and Ingrid Fleming
  
  PNAS March 17, 2020 117 (11) 5923-5930; first published March 2, 2020. https://doi.org/10.1073/pnas.1921381117
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  The functional activity of E-cadherin controls tumor cell metastasis at multiple steps
  Tae-Young Na, Leslayann Schecterson, Alisha M. Mendonsa, and Barry M. Gumbiner
  
  PNAS March 17, 2020 117 (11) 5931-5937; first published March 3, 2020. https://doi.org/10.1073/pnas.1918167117
Developmental Biology
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  Unique reproductive strategy in the swamp wallaby
  Brandon R. Menzies, Thomas B. Hildebrandt, and Marilyn B. Renfree
  
  PNAS March 17, 2020 117 (11) 5938-5942; first published March 2, 2020. https://doi.org/10.1073/pnas.1922678117
Ecology
- Open Access
  Algal photophysiology drives darkening and melt of the Greenland Ice Sheet
  From the Cover
  
  Christopher J. Williamson, Joseph Cook, Andrew Tedstone, Marian Yallop, Jenine McCutcheon, Ewa Poniecka, Douglas Campbell, Tristram Irvine-Fynn, James McQuaid, Martyn Tranter, Rupert Perkins, and Alexandre Anesio
  
  PNAS March 17, 2020 117 (11) 5694-5705; first published February 24, 2020. https://doi.org/10.1073/pnas.1918412117
Environmental Sciences
- Open Access
  Microbial evolutionary strategies in a dynamic ocean
  Nathan G. Walworth, Emily J. Zakem, John P. Dunne, Sinéad Collins, and Naomi M. Levine
  
  PNAS March 17, 2020 117 (11) 5943-5948; first published March 2, 2020. https://doi.org/10.1073/pnas.1919332117
- Open Access
  Assessing the role of live poultry trade in community-structured transmission of avian influenza in China
  From the Cover
  
  Qiqi Yang, Xiang Zhao, Philippe Lemey, Marc A. Suchard, Yuhai Bi, Weifeng Shi, Di Liu, Wenbao Qi, Guogang Zhang, Nils Chr. Stenseth, Oliver G. Pybus, and Huaiyu Tian
  
  PNAS March 17, 2020 117 (11) 5949-5954; first published March 2, 2020. https://doi.org/10.1073/pnas.1906954117
Evolution
- You have access
  Sympatric speciation of wild emmer wheat driven by ecology and chromosomal rearrangements
  Hongwei Wang, Huayan Yin, Chengzhi Jiao, Xiaojian Fang, Guiping Wang, Guangrong Li, Fei Ni, Penghuan Li, Peisen Su, Wenyang Ge, Zhongfan Lyu, Shoushen Xu, Yanhong Yang, Yongchao Hao, Xinxin Cheng, Jinxiao Zhao, Cheng Liu, Fengfeng Xu, Xin Ma, Silong Sun, Yan Zhao, Yinguang Bao, Cheng Liu, Jingjing Zhang, Tomas Pavlicek, Anfei Li, Zujun Yang, Eviatar Nevo, and Lingrang Kong
  
  PNAS March 17, 2020 117 (11) 5955-5963; first published March 2, 2020. https://doi.org/10.1073/pnas.1920415117
- Open Access
  Dramatic dietary shift maintains sequestered toxins in chemically defended snakes
  Tatsuya Yoshida, Rinako Ujiie, Alan H. Savitzky, Teppei Jono, Takato Inoue, Naoko Yoshinaga, Shunsuke Aburaya, Wataru Aoki, Hirohiko Takeuchi, Li Ding, Qin Chen, Chengquan Cao, Tein-Shun Tsai, Anslem de Silva, Dharshani Mahaulpatha, Tao Thien Nguyen, Yezhong Tang, Naoki Mori, and Akira Mori
  
  PNAS March 17, 2020 117 (11) 5964-5969; first published February 24, 2020. https://doi.org/10.1073/pnas.1919065117
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  Clonemate cotransmission supports a role for kin selection in a puppeteer parasite
  Charles D. Criscione, Bradley J. van Paridon, John S. Gilleard, and Cameron P. Goater
  
  PNAS March 17, 2020 117 (11) 5970-5976; first published March 2, 2020. https://doi.org/10.1073/pnas.1922272117
- You have access
  Integrated structural and evolutionary analysis reveals common mechanisms underlying adaptive evolution in mammals
  Greg Slodkowicz and Nick Goldman
  
  PNAS March 17, 2020 117 (11) 5977-5986; first published March 2, 2020. https://doi.org/10.1073/pnas.1916786117
Genetics
- Open Access
  Caenorhabditis elegans ADAR editing and the ERI-6/7/MOV10 RNAi pathway silence endogenous viral elements and LTR retrotransposons
  Sylvia E. J. Fischer and Gary Ruvkun
  
  PNAS March 17, 2020 117 (11) 5987-5996; first published March 2, 2020. https://doi.org/10.1073/pnas.1919028117
- You have access
  Assessing thyroid cancer risk using polygenic risk scores
  Sandya Liyanarachchi, Julius Gudmundsson, Egil Ferkingstad, Huiling He, Jon G. Jonasson, Vinicius Tragante, Folkert W. Asselbergs, Li Xu, Lambertus A. Kiemeney, Romana T. Netea-Maier, Jose I. Mayordomo, Theo S. Plantinga, Hannes Hjartarson, Jon Hrafnkelsson, Erich M. Sturgis, Pamela Brock, Fadi Nabhan, Gudmar Thorleifsson, Matthew D. Ringel, Kari Stefansson, and Albert de la Chapelle
  
  PNAS March 17, 2020 117 (11) 5997-6002; first published March 4, 2020. https://doi.org/10.1073/pnas.1919976117
- Open Access
  The regulatory and transcriptional landscape associated with carbon utilization in a filamentous fungus
  Vincent W. Wu, Nils Thieme, Lori B. Huberman, Axel Dietschmann, David J. Kowbel, Juna Lee, Sara Calhoun, Vasanth R. Singan, Anna Lipzen, Yi Xiong, Remo Monti, Matthew J. Blow, Ronan C. O’Malley, Igor V. Grigoriev, J. Philipp Benz, and N. Louise Glass
  
  PNAS March 17, 2020 117 (11) 6003-6013; first published February 28, 2020. https://doi.org/10.1073/pnas.1915611117
- You have access
  Sensory cilia as the Achilles heel of nematodes when attacked by carnivorous mushrooms
  From the Cover
  
  Ching-Han Lee, Han-Wen Chang, Ching-Ting Yang, Niaz Wali, Jiun-Jie Shie, and Yen-Ping Hsueh
  
  PNAS March 17, 2020 117 (11) 6014-6022; first published March 2, 2020. https://doi.org/10.1073/pnas.1918473117
  
  See companion article:
  Natural diversity in the predatory behavior facilitates the establishment of a robust model strain for nematode-trapping fungi
  - Mar 11, 2020
  
  See companion article:
  Mechanism of murderous mushrooms paves path for parasitic helminth halt
  - Mar 09, 2020
  
  Mechanism of murderous mushrooms paves path for parasitic helminth halt
  - Mar 09, 2020
- You have access
  Loss-of-function BK channel mutation causes impaired mitochondria and progressive cerebellar ataxia
  Xiaofei Du, Joao L. Carvalho-de-Souza, Cenfu Wei, Willy Carrasquel-Ursulaez, Yenisleidy Lorenzo, Naileth Gonzalez, Tomoya Kubota, Julia Staisch, Timothy Hain, Natalie Petrossian, Michael Xu, Ramon Latorre, Francisco Bezanilla, and Christopher M. Gomez
  
  PNAS March 17, 2020 117 (11) 6023-6034; first published March 4, 2020. https://doi.org/10.1073/pnas.1920008117
- Open Access
  DNA polymerase δ proofreads errors made by DNA polymerase ε
  Chelsea R. Bulock, Xuanxuan Xing, and Polina V. Shcherbakova
  
  PNAS March 17, 2020 117 (11) 6035-6041; first published March 2, 2020. https://doi.org/10.1073/pnas.1917624117
Immunology and Inflammation
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  Regulatory CD8 T cells that recognize Qa-1 expressed by CD4 T-helper cells inhibit rejection of heart allografts
  John Y. Choi, Siawosh K. Eskandari, Songjie Cai, Ina Sulkaj, Jean Pierre Assaker, Hazim Allos, Juliano AlHaddad, Saif A. Muhsin, Eman Alhussain, Amr Mansouri, Melissa Y. Yeung, Marc A. J. Seelen, Hye-Jung Kim, Harvey Cantor, and Jamil R. Azzi
  
  PNAS March 17, 2020 117 (11) 6042-6046; first published February 28, 2020. https://doi.org/10.1073/pnas.1918950117
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  Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8⁺ T cell stemness and antitumor immunity
  Dalton Hermans, Sanjivan Gautam, Juan C. García-Cañaveras, Daniel Gromer, Suman Mitra, Rosanne Spolski, Peng Li, Stephen Christensen, Rosa Nguyen, Jian-Xin Lin, Jangsuk Oh, Ning Du, Sharon Veenbergen, Jessica Fioravanti, Risa Ebina-Shibuya, Christopher Bleck, Leonard M. Neckers, Joshua D. Rabinowitz, Luca Gattinoni, and Warren J. Leonard
  
  PNAS March 17, 2020 117 (11) 6047-6055; first published March 2, 2020. https://doi.org/10.1073/pnas.1920413117
- Open Access
  Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism
  Adam P. Cribbs, Stefan Terlecki-Zaniewicz, Martin Philpott, Jeroen Baardman, David Ahern, Morten Lindow, Susanna Obad, Henrik Oerum, Brante Sampey, Palwinder K. Mander, Henry Penn, Paul Wordsworth, Paul Bowness, Menno de Winther, Rab K. Prinjha, Marc Feldmann, and Udo Oppermann
  
  PNAS March 17, 2020 117 (11) 6056-6066; first published March 2, 2020. https://doi.org/10.1073/pnas.1919893117
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  Signaling mechanisms of growth hormone-releasing hormone receptor in LPS-induced acute ocular inflammation
  Wei Cheng Liang, Jia Lin Ren, Qiu Xiao Yu, Jian Li, Tsz Kin Ng, Wai Kit Chu, Yong Jie Qin, Kai On Chu, Andrew V. Schally, Chi Pui Pang, and Sun On Chan
  
  PNAS March 17, 2020 117 (11) 6067-6074; first published March 2, 2020. https://doi.org/10.1073/pnas.1904532117
Medical Sciences
- Open Access
  Abrogation of esophageal carcinoma development in miR-31 knockout rats
  Louise Y. Fong, Cristian Taccioli, Alexey Palamarchuk, Guidantonio Malagoli Tagliazucchi, Ruiyan Jing, Karl J. Smalley, Sili Fan, Joseph Altemus, Oliver Fiehn, Kay Huebner, John L. Farber, and Carlo M. Croce
  
  PNAS March 17, 2020 117 (11) 6075-6085; first published March 2, 2020. https://doi.org/10.1073/pnas.1920333117
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  Immunotoxin SS1P is rapidly removed by proximal tubule cells of kidney, whose damage contributes to albumin loss in urine
  Xui-Fen Liu, Junxia Wei, Qi Zhou, Bruce A. Molitoris, Ruben Sandoval, Hisataka Kobayashi, Ryuhei Okada, Tadanobu Nagaya, Baktiar Karim, Donna Butcher, and Ira Pastan
  
  PNAS March 17, 2020 117 (11) 6086-6091; first published March 2, 2020. https://doi.org/10.1073/pnas.1919038117
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  Regulation of B cell receptor-dependent NF-κB signaling by the tumor suppressor KLHL14
  Jaewoo Choi, James D. Phelan, George W. Wright, Björn Häupl, Da Wei Huang, Arthur L. Shaffer III, Ryan M. Young, Zhuo Wang, Hong Zhao, Xin Yu, Thomas Oellerich, and Louis M. Staudt
  
  PNAS March 17, 2020 117 (11) 6092-6102; first published March 3, 2020. https://doi.org/10.1073/pnas.1921187117
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  A hepatocyte differentiation model reveals two subtypes of liver cancer with different oncofetal properties and therapeutic targets
  Ming Liu, Qian Yan, Yi Sun, Yoonhee Nam, Liang Hu, Jane HC Loong, Qi Ouyang, Yu Zhang, Hao-Long Li, Fan-En Kong, Lei Li, Yan Li, Mei-Mei Li, Wei Cheng, Ling-Xi Jiang, Shuo Fang, Xiao-Dong Yang, Jia-Qiang Mo, Yuan-Feng Gong, Yun-Qiang Tang, Yan Li, Yun-Fei Yuan, Ning-Fang Ma, Ge Lin, Stephanie Ma, Ji-Guang Wang, and Xin-Yuan Guan
  
  PNAS March 17, 2020 117 (11) 6103-6113; first published March 2, 2020. https://doi.org/10.1073/pnas.1912146117
Microbiology
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  Biphasic chemotaxis of Escherichia coli to the microbiota metabolite indole
  Jingyun Yang, Ravi Chawla, Kathy Y. Rhee, Rachit Gupta, Michael D. Manson, Arul Jayaraman, and Pushkar P. Lele
  
  PNAS March 17, 2020 117 (11) 6114-6120; first published March 2, 2020. https://doi.org/10.1073/pnas.1916974117
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  Cell-penetrating peptide inhibits retromer-mediated human papillomavirus trafficking during virus entry
  Pengwei Zhang, Ruben Moreno, Paul F. Lambert, and Daniel DiMaio
  
  PNAS March 17, 2020 117 (11) 6121-6128; first published March 2, 2020. https://doi.org/10.1073/pnas.1917748117
- Open Access
  Class A PBPs have a distinct and unique role in the construction of the pneumococcal cell wall
  Daniel Straume, Katarzyna Wiaroslawa Piechowiak, Silje Olsen, Gro Anita Stamsås, Kari Helene Berg, Morten Kjos, Maria Victoria Heggenhougen, Martín Alcorlo, Juan A. Hermoso, and Leiv Sigve Håvarstein
  
  PNAS March 17, 2020 117 (11) 6129-6138; first published March 2, 2020. https://doi.org/10.1073/pnas.1917820117
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  Structural elucidation of the Clostridioides difficile transferase toxin reveals a single-site binding mode for the enzyme
  Michael J. Sheedlo, David M. Anderson, Audrey K. Thomas, and D. Borden Lacy
  
  PNAS March 17, 2020 117 (11) 6139-6144; first published March 2, 2020. https://doi.org/10.1073/pnas.1920555117
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  Visualizing the translation and packaging of HIV-1 full-length RNA
  Jianbo Chen, Yang Liu, Bin Wu, Olga A. Nikolaitchik, Preeti R. Mohan, Jiji Chen, Vinay K. Pathak, and Wei-Shau Hu
  
  PNAS March 17, 2020 117 (11) 6145-6155; first published March 4, 2020. https://doi.org/10.1073/pnas.1917590117
Neuroscience
- Open Access
  The neural signature of numerosity by separating numerical and continuous magnitude extraction in visual cortex with frequency-tagged EEG
  Amandine Van Rinsveld, Mathieu Guillaume, Peter J. Kohler, Christine Schiltz, Wim Gevers, and Alain Content
  
  PNAS March 17, 2020 117 (11) 5726-5732; first published March 2, 2020. https://doi.org/10.1073/pnas.1917849117
- Open Access
  Active efficient coding explains the development of binocular vision and its failure in amblyopia
  Samuel Eckmann, Lukas Klimmasch, Bertram E. Shi, and Jochen Triesch
  
  PNAS March 17, 2020 117 (11) 6156-6162; first published March 2, 2020. https://doi.org/10.1073/pnas.1908100117
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  Connectivity at the origins of domain specificity in the cortical face and place networks
  Frederik S. Kamps, Cassandra L. Hendrix, Patricia A. Brennan, and Daniel D. Dilks
  
  PNAS March 17, 2020 117 (11) 6163-6169; first published March 2, 2020. https://doi.org/10.1073/pnas.1911359117
- Open Access
  Diet modulates brain network stability, a biomarker for brain aging, in young adults
  Lilianne R. Mujica-Parodi, Anar Amgalan, Syed Fahad Sultan, Botond Antal, Xiaofei Sun, Steven Skiena, Andrew Lithen, Noor Adra, Eva-Maria Ratai, Corey Weistuch, Sindhuja Tirumalai Govindarajan, Helmut H. Strey, Ken A. Dill, Steven M. Stufflebeam, Richard L. Veech, and Kieran Clarke
  
  PNAS March 17, 2020 117 (11) 6170-6177; first published March 3, 2020. https://doi.org/10.1073/pnas.1913042117
- Open Access
  Context-dependent operation of neural circuits underlies a navigation behavior in Caenorhabditis elegans
  Muneki Ikeda, Shunji Nakano, Andrew C. Giles, Linghuan Xu, Wagner Steuer Costa, Alexander Gottschalk, and Ikue Mori
  
  PNAS March 17, 2020 117 (11) 6178-6188; first published March 2, 2020. https://doi.org/10.1073/pnas.1918528117
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  Nf1 deletion results in depletion of the Lhx6 transcription factor and a specific loss of parvalbumin⁺ cortical interneurons
  Kartik Angara, Emily Ling-Lin Pai, Stephanie M. Bilinovich, April M. Stafford, Julie T. Nguyen, Katie X. Li, Anirban Paul, John L. Rubenstein, and Daniel Vogt
  
  PNAS March 17, 2020 117 (11) 6189-6195; first published March 2, 2020. https://doi.org/10.1073/pnas.1915458117
- Open Access
  Anterior cingulate cortex is necessary for adaptation of action plans
  Adam T. Brockett, Stephen S. Tennyson, Coreylyn A. deBettencourt, Fatou Gaye, and Matthew R. Roesch
  
  PNAS March 17, 2020 117 (11) 6196-6204; first published March 4, 2020. https://doi.org/10.1073/pnas.1919303117
Plant Biology
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  CUL3^BPM E3 ubiquitin ligases regulate MYC2, MYC3, and MYC4 stability and JA responses
  Jose Manuel Chico, Esther Lechner, Gemma Fernandez-Barbero, Esther Canibano, Gloria García-Casado, Jose Manuel Franco-Zorrilla, Philippe Hammann, Angel M. Zamarreño, Jose M. García-Mina, Vicente Rubio, Pascal Genschik, and Roberto Solano
  
  PNAS March 17, 2020 117 (11) 6205-6215; first published March 2, 2020. https://doi.org/10.1073/pnas.1912199117
- You have access
  Triacylglycerol and phytyl ester synthesis in Synechocystis sp. PCC6803
  Mohammed Aizouq, Helga Peisker, Katharina Gutbrod, Michael Melzer, Georg Hölzl, and Peter Dörmann
  
  PNAS March 17, 2020 117 (11) 6216-6222; first published March 2, 2020. https://doi.org/10.1073/pnas.1915930117
- Open Access
  Carbon export from leaves is controlled via ubiquitination and phosphorylation of sucrose transporter SUC2
  From the Cover
  
  Qiyu Xu, Shijiao Yin, Yue Ma, Min Song, Yingjie Song, Shuaicheng Mu, Yunsong Li, Xiaohui Liu, Yunjuan Ren, Chen Gao, Shaolin Chen, and Johannes Liesche
  
  PNAS March 17, 2020 117 (11) 6223-6230; first published March 2, 2020. https://doi.org/10.1073/pnas.1912754117
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  Transcriptional repression specifies the central cell for double fertilization
  Meng-Xia Zhang, Shan-Shan Zhu, Yong-Chao Xu, Ya-Long Guo, Wei-Cai Yang, and Hong-Ju Li
  
  PNAS March 17, 2020 117 (11) 6231-6236; first published March 4, 2020. https://doi.org/10.1073/pnas.1909465117
- Open Access
  Regulation of stomatal development by stomatal lineage miRNAs
  Jiali Zhu, Ji-Hwan Park, Seulbee Lee, Jae Ho Lee, Daehee Hwang, June M. Kwak, and Yun Ju Kim
  
  PNAS March 17, 2020 117 (11) 6237-6245; first published March 2, 2020. https://doi.org/10.1073/pnas.1919722117
Psychological and Cognitive Sciences
- You have access
  Eye movements support behavioral pattern completion
  Jordana S. Wynn, Jennifer D. Ryan, and Bradley R. Buchsbaum
  
  PNAS March 17, 2020 117 (11) 6246-6254; first published March 2, 2020. https://doi.org/10.1073/pnas.1917586117
- You have access
  Speakers are able to categorize vowels based on tongue somatosensation
  Jean-François Patri, David J. Ostry, Julien Diard, Jean-Luc Schwartz, Pamela Trudeau-Fisette, Christophe Savariaux, and Pascal Perrier
  
  PNAS March 17, 2020 117 (11) 6255-6263; first published March 2, 2020. https://doi.org/10.1073/pnas.1911142117
Systems Biology
- Open Access
  Metabolic and genetic basis for auxotrophies in Gram-negative species
  Yara Seif, Kumari Sonal Choudhary, Ying Hefner, Amitesh Anand, Laurence Yang, and Bernhard O. Palsson
  
  PNAS March 17, 2020 117 (11) 6264-6273; first published March 4, 2020. https://doi.org/10.1073/pnas.1910499117

Corrections

You have access
Correction for Shi et al., Deep elastic strain engineering of bandgap through machine learning
PNAS March 17, 2020 117 (11) 6274; first published March 9, 2020. https://doi.org/10.1073/pnas.2002727117
You have access
Correction for Kovalev et al., High-resolution structural insights into the heliorhodopsin family
PNAS March 17, 2020 117 (11) 6275; first published March 16, 2020. https://doi.org/10.1073/pnas.2003117117
You have access
Correction for Hsu et al., Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration
PNAS March 17, 2020 117 (11) 6276; first published March 9, 2020. https://doi.org/10.1073/pnas.2003198117
You have access
Correction for Cristopher Bragg et al., Disease onset in X-linked dystonia-parkinsonism correlates with expansion of a hexameric repeat within an SVA retrotransposon in TAF1
PNAS March 17, 2020 117 (11) 6277; first published March 9, 2020. https://doi.org/10.1073/pnas.2003190117

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