Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection | PNAS

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Edited by Michael B. A. Oldstone, Scripps Research Institute, La Jolla, CA, and approved February 7, 2020 (received for review December 16, 2019)

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vol. 117 no. 12 6771-6776

DOI:

https://doi.org/10.1073/pnas.1922083117

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National Academy of Sciences

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History:

Published in issue March 24, 2020.
Published first February 13, 2020.

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Previous version (February 13, 2020 - 11:24).
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Copyright © 2020 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).

Author Information

Emmie de Wit^a,¹,
Friederike Feldmann^b,
Jacqueline Cronin^a,
Robert Jordan^c,
Atsushi Okumura^d,
Tina Thomas^a,
Dana Scott^b,
Tomas Cihlar^c, and
Heinz Feldmann^a

^aLaboratory of Virology, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840;
^bRocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840;
^cBiology Department, Gilead Sciences, Foster City, CA 94404;
^dCenter for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032

Edited by Michael B. A. Oldstone, Scripps Research Institute, La Jolla, CA, and approved February 7, 2020 (received for review December 16, 2019)

Footnotes

↵¹To whom correspondence may be addressed. Email: Emmie.deWit{at}nih.gov.

Author contributions: E.d.W., R.J., and H.F. designed research; E.d.W., F.F., J.C., A.O., T.T., and D.S. performed research; T.C. contributed new reagents/analytic tools; E.d.W., A.O., and D.S. analyzed data; E.d.W. and H.F. wrote the paper; and F.F., J.C., R.J., A.O., T.T., D.S., and T.C. read and approved the manuscript.
Competing interest statement: The authors affiliated with Gilead Sciences are employees of the company and may own company stock; R.J. holds a patent on the use of remdesivir to treat Filovirus infections. The authors affiliated with NIH have no conflict of interest to report.
This article is a PNAS Direct Submission.
Data deposition: All data discussed here will be made available to readers upon request.
This article contains supporting information online at https://www.pnas.org/lookup/suppl/doi:10.1073/pnas.1922083117/-/DCSupplemental.

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Article usage

Article usage: February 2020 to January 2021

	Abstract	Full	Pdf
Feb 2020	1669	30455	3653
Mar 2020	2433	20888	6300
Apr 2020	1801	12079	5777
May 2020	1189	5832	2758
Jun 2020	384	2663	819
Jul 2020	255	2575	643
Aug 2020	170	1550	400
Sep 2020	228	1297	404
Oct 2020	391	1817	490
Nov 2020	245	1196	293
Dec 2020	183	822	180
Total 2020	8948	81174	21717
Jan 2021	119	843	178
Total 2021	119	843	178
Total	9067	82017	21895

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Proceedings of the National Academy of Sciences: 117 (12)

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Biological Sciences
Microbiology

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