Hypnotic effect of thalidomide is independent of teratogenic ubiquitin/proteasome pathway

^aInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan;
^bDepartment of Cellular Neurobiology, Brain Research Institute, Niigata University, Chuo-ku Niigata 951-8585 Japan;
^cDepartment of Anatomy, Faculty of Medicine, Toho University, Ota-ku, Tokyo 143-8540, Japan;
^dDepartment of Chemical Biology, Tokyo Medical University, Shinjuku-ku, Tokyo 160-8402, Japan;
^eDepartment of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390;
^fLife Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba, 305-8575 Tsukuba, Japan;
^gR&D Center for Frontiers of MIRAI in Policy and Technology, University of Tsukuba, 305-8575 Tsukuba, Japan

Contributed by Masashi Yanagisawa, July 19, 2020 (sent for review October 10, 2019; reviewed by Ying-Hui Fu and Toru Takumi)

Footnotes

↵¹To whom correspondence may be addressed. Email: yanagisawa.masa.fu{at}u.tsukuba.ac.jp.

Author contributions: Y.H., H.F., K.E.V., and M.Y. designed research; Y.H., T.K., and M.S. performed research; M.A., K.S., and H.H. contributed new reagents/analytic tools; Y.H. and T.K. analyzed data; and Y.H., K.E.V., and M.Y. wrote the paper.
Reviewers: Y.-H.F., University of California, San Francisco; and T.T., RIKEN.
The authors declare no competing interest.