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Edited by Alexander M. Klibanov, Massachusetts Institute of Technology, Cambridge, MA, and approved August 17, 2020 (received for review April 8, 2020)
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Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors
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- Biological Sciences
- Biophysics and Computational Biology
- Physical Sciences
- Chemistry
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- Abstract
- Aggregation Kinetics in the Presence of an Inhibitor
- Integrated Rate Laws for Inhibited-Aggregation Kinetics
- The Interplay between Kinetics and Thermodynamics Generates a Rich Inhibition-Phase Behavior
- Physical Design Principles for Effective Inhibitors and Illustrative Examples on Experimental Data
- Summary and Outlook
- Data Availability.
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