Table of Contents

Biological Sciences

• Applied Biological Sciences

  • Open Access

    Apex structures enhance water drainage on leaves

    Ting Wang, Yifan Si, Haoyu Dai, Chuxin Li, Can Gao, Zhichao Dong, and Lei Jiang

    PNAS January 28, 2020 117 (4) 1890-1894; first published January 14, 2020. https://doi.org/10.1073/pnas.1909924117
  • Open Access

    Controlled phage therapy by photothermal ablation of specific bacterial species using gold nanorods targeted by chimeric phages

    Huan Peng, Raymond E. Borg, Liam P. Dow, Beth L. Pruitt, and Irene A. Chen

    PNAS January 28, 2020 117 (4) 1951-1961; first published January 13, 2020. https://doi.org/10.1073/pnas.1913234117

• Biochemistry

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    CK1α, CK1δ, and CK1ε are necrosome components which phosphorylate serine 227 of human RIPK3 to activate necroptosis

    Sarah Hanna-Addams, Shuzhen Liu, Hua Liu, She Chen, and Zhigao Wang

    PNAS January 28, 2020 117 (4) 1962-1970; first published January 13, 2020. https://doi.org/10.1073/pnas.1917112117
  • Open Access

    A long-distance rRNA base pair impacts the ability of macrolide antibiotics to kill bacteria

    Maxim S. Svetlov, Sophie Cohen, Nada Alsuhebany, Nora Vázquez-Laslop, and Alexander S. Mankin

    PNAS January 28, 2020 117 (4) 1971-1975; first published January 13, 2020. https://doi.org/10.1073/pnas.1918948117
  • Open Access

    Missing regions within the molecular architecture of human fibrin clots structurally resolved by XL-MS and integrative structural modeling

    Oleg Klykov, Carmen van der Zwaan, Albert J. R. Heck, Alexander B. Meijer, and Richard A. Scheltema

    PNAS January 28, 2020 117 (4) 1976-1987; first published January 10, 2020. https://doi.org/10.1073/pnas.1911785117

• Biophysics and Computational Biology

  • Open Access

    Polymeric sheet actuators with programmable bioinstructivity

    Zijun Deng, Weiwei Wang, Xun Xu, Oliver E. C. Gould, Karl Kratz, Nan Ma, and Andreas Lendlein

    PNAS January 28, 2020 117 (4) 1895-1901; first published January 13, 2020. https://doi.org/10.1073/pnas.1910668117
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    Resting state structure of the hyperdepolarization activated two-pore channel 3

    Miles Sasha Dickinson, Alexander Myasnikov, Jacob Eriksen, Nicole Poweleit, and Robert M. Stroud

    PNAS January 28, 2020 117 (4) 1988-1993; first published January 10, 2020. https://doi.org/10.1073/pnas.1915144117

• Cell Biology

  • Open Access

    Innate immune receptor NOD2 mediates LGR5⁺ intestinal stem cell protection against ROS cytotoxicity via mitophagy stimulation

    Antonin Levy, Aline Stedman, Eric Deutsch, Françoise Donnadieu, Herbert W. Virgin, Philippe J. Sansonetti, and Giulia Nigro

    PNAS January 28, 2020 117 (4) 1994-2003; first published January 9, 2020. https://doi.org/10.1073/pnas.1902788117
  • Open Access

    The nutrient sensor OGT regulates Hipk stability and tumorigenic-like activities in Drosophila

    Kenneth Kin Lam Wong, Ta-Wei Liu, Jessica M. Parker, Donald A. R. Sinclair, Yi-Yun Chen, Kay-Hooi Khoo, David J. Vocadlo, and Esther M. Verheyen

    PNAS January 28, 2020 117 (4) 2004-2013; first published January 13, 2020. https://doi.org/10.1073/pnas.1912894117
  • Open Access

    Single-cell tracking demonstrates copper chaperone Atox1 to be required for breast cancer cell migration

    Stéphanie Blockhuys, Xiaolu Zhang, and Pernilla Wittung-Stafshede

    PNAS January 28, 2020 117 (4) 2014-2019; first published January 13, 2020. https://doi.org/10.1073/pnas.1910722117
  • Open Access

    CTCF mediates chromatin looping via N-terminal domain-dependent cohesin retention

    Elena M. Pugacheva, Naoki Kubo, Dmitri Loukinov, Md Tajmul, Sungyun Kang, Alexander L. Kovalchuk, Alexander V. Strunnikov, Gabriel E. Zentner, Bing Ren, and Victor V. Lobanenkov

    PNAS January 28, 2020 117 (4) 2020-2031; first published January 14, 2020. https://doi.org/10.1073/pnas.1911708117
  • Open Access

    Trop2 is a driver of metastatic prostate cancer with neuroendocrine phenotype via PARP1

    En-Chi Hsu, Meghan A. Rice, Abel Bermudez, Fernando Jose Garcia Marques, Merve Aslan, Shiqin Liu, Ali Ghoochani, Chiyuan Amy Zhang, Yun-Sheng Chen, Aimen Zlitni, Sahil Kumar, Rosalie Nolley, Frezghi Habte, Michelle Shen, Kashyap Koul, Donna M. Peehl, Amina Zoubeidi, Sanjiv S. Gambhir, Christian A. Kunder, Sharon J. Pitteri, James D. Brooks, and Tanya Stoyanova

    PNAS January 28, 2020 117 (4) 2032-2042; first published January 13, 2020. https://doi.org/10.1073/pnas.1905384117

• Ecology

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    Generalists are more specialized in low-resource habitats, increasing stability of ecological network structure

    Moria L. Robinson and Sharon Y. Strauss

    PNAS January 28, 2020 117 (4) 2043-2048; first published January 13, 2020. https://doi.org/10.1073/pnas.1820143117

• Environmental Sciences

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    Global warming accelerates uptake of atmospheric mercury in regions experiencing glacier retreat

    Xun Wang, Ji Luo, Wei Yuan, Che-Jen Lin, Feiyue Wang, Chen Liu, Genxu Wang, and Xinbin Feng

    PNAS January 28, 2020 117 (4) 2049-2055; first published January 13, 2020. https://doi.org/10.1073/pnas.1906930117

• Evolution

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    Extreme offspring ornamentation in American coots is favored by selection within families, not benefits to conspecific brood parasites

    • From the Cover

    Bruce E. Lyon and Daizaburo Shizuka

    PNAS January 28, 2020 117 (4) 2056-2064; first published December 30, 2019. https://doi.org/10.1073/pnas.1913615117

    See companion article:

    • Extreme offspring ornamentation in American coots is favored by selection within families, not benefits to conspecific brood parasites

      - Dec 30, 2019
    • The mystery of ornate offspring

      - Feb 04, 2020
  • You have access

    Anaerobic peroxisomes in Mastigamoeba balamuthi

    Tien Le, Vojtěch Žárský, Eva Nývltová, Petr Rada, Karel Harant, Marie Vancová, Zdeněk Verner, Ivan Hrdý, and Jan Tachezy

    PNAS January 28, 2020 117 (4) 2065-2075; first published January 13, 2020. https://doi.org/10.1073/pnas.1909755117

• Medical Sciences

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    Metabolic dysregulation in the Atp7b^−/− Wilson’s disease mouse model

    Clavia Ruth Wooton-Kee, Matthew Robertson, Ying Zhou, Bingning Dong, Zhen Sun, Kang Ho Kim, Hailan Liu, Yong Xu, Nagireddy Putluri, Pradip Saha, Cristian Coarfa, David D. Moore, and Alli M. Nuotio-Antar

    PNAS January 28, 2020 117 (4) 2076-2083; first published January 10, 2020. https://doi.org/10.1073/pnas.1914267117
  • Open Access

    RAP80 and BRCA1 PARsylation protect chromosome integrity by preventing retention of BRCA1-B/C complexes in DNA repair foci

    Jekaterina Vohhodina, Kimberly J. Toomire, Sarah A. Petit, Goran Micevic, Geeta Kumari, Vladimir V. Botchkarev Jr, Zhe Li, David M. Livingston, and Yiduo Hu

    PNAS January 28, 2020 117 (4) 2084-2091; first published January 13, 2020. https://doi.org/10.1073/pnas.1908003117
  • Open Access

    Imaging breast cancer using hyperpolarized carbon-13 MRI

    Ferdia A. Gallagher, Ramona Woitek, Mary A. McLean, Andrew B. Gill, Raquel Manzano Garcia, Elena Provenzano, Frank Riemer, Joshua Kaggie, Anita Chhabra, Stephan Ursprung, James T. Grist, Charlie J. Daniels, Fulvio Zaccagna, Marie-Christine Laurent, Matthew Locke, Sarah Hilborne, Amy Frary, Turid Torheim, Chris Boursnell, Amy Schiller, Ilse Patterson, Rhys Slough, Bruno Carmo, Justine Kane, Heather Biggs, Emma Harrison, Surrin S. Deen, Andrew Patterson, Titus Lanz, Zoya Kingsbury, Mark Ross, Bristi Basu, Richard Baird, David J. Lomas, Evis Sala, James Wason, Oscar M. Rueda, Suet-Feung Chin, Ian B. Wilkinson, Martin J. Graves, Jean E. Abraham, Fiona J. Gilbert, Carlos Caldas, and Kevin M. Brindle

    PNAS January 28, 2020 117 (4) 2092-2098; first published January 21, 2020. https://doi.org/10.1073/pnas.1913841117

• Microbiology

  • Open Access

    Structure of a rabies virus polymerase complex from electron cryo-microscopy

    Joshua A. Horwitz, Simon Jenni, Stephen C. Harrison, and Sean P. J. Whelan

    PNAS January 28, 2020 117 (4) 2099-2107; first published January 17, 2020. https://doi.org/10.1073/pnas.1918809117

    See companion article:

    • Structure of a rabies virus polymerase complex from electron cryo-microscopy

      - Jan 17, 2020
    • Insight into the multifunctional RNA synthesis machine of rabies virus

      - Jan 28, 2020
  • You have access

    Precise CRISPR/Cas9 editing of the NHE1 gene renders chickens resistant to the J subgroup of avian leukosis virus

    Anna Koslová, Pavel Trefil, Jitka Mucksová, Markéta Reinišová, Jiří Plachý, Jiří Kalina, Dana Kučerová, Josef Geryk, Veronika Krchlíková, Barbora Lejčková, and Jiří Hejnar

    PNAS January 28, 2020 117 (4) 2108-2112; first published January 21, 2020. https://doi.org/10.1073/pnas.1913827117
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    Coordination of host and symbiont gene expression reveals a metabolic tug-of-war between aphids and Buchnera

    Thomas E. Smith and Nancy A. Moran

    PNAS January 28, 2020 117 (4) 2113-2121; first published January 21, 2020. https://doi.org/10.1073/pnas.1916748117
  • Open Access

    A molecularly engineered antiviral banana lectin inhibits fusion and is efficacious against influenza virus infection in vivo

    Evelyn M. Covés-Datson, Steven R. King, Maureen Legendre, Auroni Gupta, Susana M. Chan, Emily Gitlin, Vikram V. Kulkarni, Jezreel Pantaleón García, Donald F. Smee, Elke Lipka, Scott E. Evans, E. Bart Tarbet, Akira Ono, and David M. Markovitz

    PNAS January 28, 2020 117 (4) 2122-2132; first published January 13, 2020. https://doi.org/10.1073/pnas.1915152117

• Neuroscience

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    Ras acts as a molecular switch between two forms of consolidated memory in Drosophila

    Nathaniel C. Noyes, Erica Walkinshaw, and Ronald L. Davis

    PNAS January 28, 2020 117 (4) 2133-2139; first published January 13, 2020. https://doi.org/10.1073/pnas.1819925117
  • You have access

    Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA–GABA transmission in highly addicted rats

    • From the Cover

    Marsida Kallupi, Lieselot L. G. Carrette, Jenni Kononoff, Leah C. Solberg Woods, Abraham A. Palmer, Paul Schweitzer, Olivier George, and Giordano de Guglielmo

    PNAS January 28, 2020 117 (4) 2140-2148; first published January 13, 2020. https://doi.org/10.1073/pnas.1915143117
  • You have access

    Brain-wide functional architecture remodeling by alcohol dependence and abstinence

    Adam Kimbrough, Daniel J. Lurie, Andres Collazo, Max Kreifeldt, Harpreet Sidhu, Giovana Camila Macedo, Mark D’Esposito, Candice Contet, and Olivier George

    PNAS January 28, 2020 117 (4) 2149-2159; first published January 14, 2020. https://doi.org/10.1073/pnas.1909915117
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    Oligodendroglial connexin 47 regulates neuroinflammation upon autoimmune demyelination in a novel mouse model of multiple sclerosis

    Yinan Zhao, Ryo Yamasaki, Hiroo Yamaguchi, Satoshi Nagata, Hayato Une, Yiwen Cui, Katsuhisa Masaki, Yuko Nakamuta, Kyoko Iinuma, Mitsuru Watanabe, Takuya Matsushita, Noriko Isobe, and Jun-ichi Kira

    PNAS January 28, 2020 117 (4) 2160-2169; first published January 13, 2020. https://doi.org/10.1073/pnas.1901294117
  • Open Access

    TrkB hyperactivity contributes to brain dysconnectivity, epileptogenesis, and anxiety in zebrafish model of Tuberous Sclerosis Complex

    Magdalena Kedra, Katarzyna Banasiak, Katarzyna Kisielewska, Lidia Wolinska-Niziol, Jacek Jaworski, and Justyna Zmorzynska

    PNAS January 28, 2020 117 (4) 2170-2179; first published January 13, 2020. https://doi.org/10.1073/pnas.1910834117

• Physiology

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    Physiological responses to gravity in an insect

    Jon F. Harrison, Khaled Adjerid, Anelia Kassi, C. Jaco Klok, John M. VandenBrooks, Meghan E. Duell, Jacob B. Campbell, Stav Talal, Christopher D. Abdo, Kamel Fezzaa, Hodjat Pendar, and John J. Socha

    PNAS January 28, 2020 117 (4) 2180-2186; first published January 13, 2020. https://doi.org/10.1073/pnas.1915424117
  • Open Access

    HSD3B1 genotype identifies glucocorticoid responsiveness in severe asthma

    Joe Zein, Benjamin Gaston, Peter Bazeley, Mark D. DeBoer, Robert P. Igo Jr, Eugene R. Bleecker, Deborah Meyers, Suzy Comhair, Nadzeya V. Marozkina, Calvin Cotton, Mona Patel, Mohammad Alyamani, Weiling Xu, William W. Busse, William J. Calhoun, Victor Ortega, Gregory A. Hawkins, Mario Castro, Kian Fan Chung, John V. Fahy, Anne M. Fitzpatrick, Elliot Israel, Nizar N. Jarjour, Bruce Levy, David T. Mauger, Wendy C. Moore, Patricia Noel, Stephen P. Peters, W. Gerald Teague, Sally E. Wenzel, Serpil C. Erzurum, and Nima Sharifi

    PNAS January 28, 2020 117 (4) 2187-2193; first published January 13, 2020. https://doi.org/10.1073/pnas.1918819117
  • Open Access

    LINGO1 is a regulatory subunit of large conductance, Ca²⁺-activated potassium channels

    Srikanth Dudem, Roddy J. Large, Shruti Kulkarni, Heather McClafferty, Irina G. Tikhonova, Gerard P. Sergeant, Keith D. Thornbury, Michael J. Shipston, Brian A. Perrino, and Mark A. Hollywood

    PNAS January 28, 2020 117 (4) 2194-2200; first published January 13, 2020. https://doi.org/10.1073/pnas.1916715117

• Plant Biology

  • Open Access

    Multifeature analyses of vascular cambial cells reveal longevity mechanisms in old Ginkgo biloba trees

    • From the Cover

    Li Wang, Jiawen Cui, Biao Jin, Jianguo Zhao, Huimin Xu, Zhaogeng Lu, Weixing Li, Xiaoxia Li, Linling Li, Eryuan Liang, Xiaolan Rao, Shufang Wang, Chunxiang Fu, Fuliang Cao, Richard A. Dixon, and Jinxing Lin

    PNAS January 28, 2020 117 (4) 2201-2210; first published January 13, 2020. https://doi.org/10.1073/pnas.1916548117
  • Open Access

    Insect herbivory antagonizes leaf cooling responses to elevated temperature in tomato

    Nathan E. Havko, Michael R. Das, Alan M. McClain, George Kapali, Thomas D. Sharkey, and Gregg A. Howe

    PNAS January 28, 2020 117 (4) 2211-2217; first published January 21, 2020. https://doi.org/10.1073/pnas.1913885117

• Population Biology

  • Open Access

    Effective fisheries management instrumental in improving fish stock status

    Ray Hilborn, Ricardo Oscar Amoroso, Christopher M. Anderson, Julia K. Baum, Trevor A. Branch, Christopher Costello, Carryn L. de Moor, Abdelmalek Faraj, Daniel Hively, Olaf P. Jensen, Hiroyuki Kurota, L. Richard Little, Pamela Mace, Tim McClanahan, Michael C. Melnychuk, Cóilín Minto, Giacomo Chato Osio, Ana M. Parma, Maite Pons, Susana Segurado, Cody S. Szuwalski, Jono R. Wilson, and Yimin Ye

    PNAS January 28, 2020 117 (4) 2218-2224; first published January 13, 2020. https://doi.org/10.1073/pnas.1909726116

• Systems Biology

  • Open Access

    A scalable pipeline for designing reconfigurable organisms

    • Cozzarelli Prize Winner

    Sam Kriegman, Douglas Blackiston, Michael Levin, and Josh Bongard

    PNAS January 28, 2020 117 (4) 1853-1859; first published January 13, 2020. https://doi.org/10.1073/pnas.1910837117
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    Membrane molecular crowding enhances MreB polymerization to shape synthetic cells from spheres to rods

    David Garenne, Albert Libchaber, and Vincent Noireaux

    PNAS January 28, 2020 117 (4) 1902-1909; first published January 13, 2020. https://doi.org/10.1073/pnas.1914656117