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Research Article

Genome mapping of a LYST mutation in corn snakes indicates that vertebrate chromatophore vesicles are lysosome-related organelles

View ORCID ProfileAsier Ullate-Agote, Ingrid Burgelin, Adrien Debry, Carine Langrez, Florent Montange, View ORCID ProfileRodrigue Peraldi, View ORCID ProfileJean Daraspe, View ORCID ProfileHenrik Kaessmann, View ORCID ProfileMichel C. Milinkovitch, and View ORCID ProfileAthanasia C. Tzika
PNAS October 20, 2020 117 (42) 26307-26317; first published October 5, 2020; https://doi.org/10.1073/pnas.2003724117
Asier Ullate-Agote
aLaboratory of Artificial & Natural Evolution (LANE), Department of Genetics & Evolution, University of Geneva, CH-1211 Geneva, Switzerland;
bSIB Swiss Institute of Bioinformatics, Switzerland;
cInstitute of Genetics and Genomics of Geneva (iGE3), University of Geneva, Geneva, Switzerland;
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  • ORCID record for Asier Ullate-Agote
Ingrid Burgelin
aLaboratory of Artificial & Natural Evolution (LANE), Department of Genetics & Evolution, University of Geneva, CH-1211 Geneva, Switzerland;
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Adrien Debry
aLaboratory of Artificial & Natural Evolution (LANE), Department of Genetics & Evolution, University of Geneva, CH-1211 Geneva, Switzerland;
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Carine Langrez
aLaboratory of Artificial & Natural Evolution (LANE), Department of Genetics & Evolution, University of Geneva, CH-1211 Geneva, Switzerland;
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Florent Montange
aLaboratory of Artificial & Natural Evolution (LANE), Department of Genetics & Evolution, University of Geneva, CH-1211 Geneva, Switzerland;
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Rodrigue Peraldi
aLaboratory of Artificial & Natural Evolution (LANE), Department of Genetics & Evolution, University of Geneva, CH-1211 Geneva, Switzerland;
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  • ORCID record for Rodrigue Peraldi
Jean Daraspe
dFaculté de Biologie et de Médecine, Electron Microscopy Facility, University of Lausanne, CH-1015 Lausanne, Switzerland;
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  • ORCID record for Jean Daraspe
Henrik Kaessmann
eDKFZ-ZMBH Alliance, Center for Molecular Biology of Heidelberg University (ZMBH), D-69120 Heidelberg, Germany
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  • ORCID record for Henrik Kaessmann
Michel C. Milinkovitch
aLaboratory of Artificial & Natural Evolution (LANE), Department of Genetics & Evolution, University of Geneva, CH-1211 Geneva, Switzerland;
bSIB Swiss Institute of Bioinformatics, Switzerland;
cInstitute of Genetics and Genomics of Geneva (iGE3), University of Geneva, Geneva, Switzerland;
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  • ORCID record for Michel C. Milinkovitch
Athanasia C. Tzika
aLaboratory of Artificial & Natural Evolution (LANE), Department of Genetics & Evolution, University of Geneva, CH-1211 Geneva, Switzerland;
bSIB Swiss Institute of Bioinformatics, Switzerland;
cInstitute of Genetics and Genomics of Geneva (iGE3), University of Geneva, Geneva, Switzerland;
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  • ORCID record for Athanasia C. Tzika
  • For correspondence: athanasia.tzika@unige.ch
  1. Edited by Günter P. Wagner, Yale University, New Haven, CT, and approved September 3, 2020 (received for review February 27, 2020)

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Article Information

vol. 117 no. 42 26307-26317
DOI: 
https://doi.org/10.1073/pnas.2003724117
PubMed: 
33020272

Published By: 
National Academy of Sciences
Print ISSN: 
0027-8424
Online ISSN: 
1091-6490
History: 
  • Published in issue October 20, 2020.
  • Published first October 5, 2020.

Article Versions

  • Previous version (October 5, 2020 - 12:05).
  • You are viewing the most recent version of this article.
Copyright & Usage: 
Copyright © 2020 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY).

Author Information

  1. Asier Ullate-Agotea,b,c,
  2. Ingrid Burgelina,
  3. Adrien Debrya,
  4. Carine Langreza,
  5. Florent Montangea,
  6. Rodrigue Peraldia,
  7. Jean Darasped,
  8. Henrik Kaessmanne,
  9. Michel C. Milinkovitcha,b,c, and
  10. Athanasia C. Tzikaa,b,c,1
  1. aLaboratory of Artificial & Natural Evolution (LANE), Department of Genetics & Evolution, University of Geneva, CH-1211 Geneva, Switzerland;
  2. bSIB Swiss Institute of Bioinformatics, Switzerland;
  3. cInstitute of Genetics and Genomics of Geneva (iGE3), University of Geneva, Geneva, Switzerland;
  4. dFaculté de Biologie et de Médecine, Electron Microscopy Facility, University of Lausanne, CH-1015 Lausanne, Switzerland;
  5. eDKFZ-ZMBH Alliance, Center for Molecular Biology of Heidelberg University (ZMBH), D-69120 Heidelberg, Germany
  1. Edited by Günter P. Wagner, Yale University, New Haven, CT, and approved September 3, 2020 (received for review February 27, 2020)

Footnotes

  • ↵1To whom correspondence may be addressed. Email: athanasia.tzika{at}unige.ch.
  • Author contributions: A.C.T. designed research; I.B., A.D., C.L., F.M., R.P., J.D., H.K., and A.C.T. performed research; A.U.-A. and A.C.T. analyzed data; and A.U.-A., M.C.M., and A.C.T. wrote the paper.

  • The authors declare no competing interest.

  • This article is a PNAS Direct Submission.

  • This article contains supporting information online at https://www.pnas.org/lookup/suppl/doi:10.1073/pnas.2003724117/-/DCSupplemental.

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Genome mapping of a LYST mutation in corn snakes indicates that vertebrate chromatophore vesicles are lysosome-related organelles
Asier Ullate-Agote, Ingrid Burgelin, Adrien Debry, Carine Langrez, Florent Montange, Rodrigue Peraldi, Jean Daraspe, Henrik Kaessmann, Michel C. Milinkovitch, Athanasia C. Tzika
Proceedings of the National Academy of Sciences Oct 2020, 117 (42) 26307-26317; DOI: 10.1073/pnas.2003724117

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Genome mapping of a LYST mutation in corn snakes indicates that vertebrate chromatophore vesicles are lysosome-related organelles
Asier Ullate-Agote, Ingrid Burgelin, Adrien Debry, Carine Langrez, Florent Montange, Rodrigue Peraldi, Jean Daraspe, Henrik Kaessmann, Michel C. Milinkovitch, Athanasia C. Tzika
Proceedings of the National Academy of Sciences Oct 2020, 117 (42) 26307-26317; DOI: 10.1073/pnas.2003724117
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