Proceedings of the National Academy of Sciences: 117 (44)

New Research In

November 03, 2020; vol. 117 no. 44

This Week in PNAS

This week's research highlights

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In This Issue
PNAS November 3, 2020 117 (44) 27063-27065; https://doi.org/10.1073/iti4420117

Inner Workings

An over-the-shoulder look at scientists at work

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Inner Workings: Crop researchers harness artificial intelligence to breed crops for the changing climate
Front Matter
Carolyn Beans

PNAS November 3, 2020 117 (44) 27066-27069; first published October 14, 2020. https://doi.org/10.1073/pnas.2018732117

Commentaries

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Another step toward demystifying deep neural networks
Michael Elad, Dror Simon, and Aviad Aberdam

PNAS November 3, 2020 117 (44) 27070-27072; first published October 15, 2020. https://doi.org/10.1073/pnas.2018957117
See companion article:
Prevalence of neural collapse during the terminal phase of deep learning training
- Sep 21, 2020
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The human quest for discovering mathematical beauty in the arts
Stefano Balietti

PNAS November 3, 2020 117 (44) 27073-27075; first published October 23, 2020. https://doi.org/10.1073/pnas.2018652117
See companion article:
Dissecting landscape art history with information theory
- Oct 12, 2020

Letters

Open Access
Protective effect of mandatory face masks in the public—relevant variables with likely impact on outcome were not considered
Günter Kampf

PNAS November 3, 2020 117 (44) 27076-27077; first published October 13, 2020. https://doi.org/10.1073/pnas.2012415117
Open Access
Do face masks help? is not the question
Qin Xiang Ng, Michelle Lee Zhi Qing De Deyn, and Wee Song Yeo

PNAS November 3, 2020 117 (44) 27078-27079; first published October 6, 2020. https://doi.org/10.1073/pnas.2012241117
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The Kinsey scale is ill-suited to most sexuality research because it does not measure a single construct
Brendan P. Zietsch and Morgan J. Sidari

PNAS November 3, 2020 117 (44) 27080; https://doi.org/10.1073/pnas.2015820117
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Reply to Zietsch and Sidari: Male sexual arousal patterns (and sexual orientation) are partly unidimensional
J. Michael Bailey and J. Jabbour

PNAS November 3, 2020 117 (44) 27081; https://doi.org/10.1073/pnas.2018061117
See companion article:
Robust evidence for bisexual orientation among men
- Jul 20, 2020
Open Access
β-Arrestin2 is increased in liver fibrosis in humans and rodents
Robert Schierwagen, Peter Dietrich, Sabine Klein, Frank Erhard Uschner, Cristina Ortiz, Olaf Tyc, Sandra Torres, Claus Hellerbrand, Tilman Sauerbruch, and Jonel Trebicka

PNAS November 3, 2020 117 (44) 27082-27084; https://doi.org/10.1073/pnas.2014337117
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Reply to Schierwagen et al.: β-Arrestins in liver disease
Songling Liu, Louis M. Luttrell, Richard T. Premont, and Don C. Rockey

PNAS November 3, 2020 117 (44) 27085-27086; https://doi.org/10.1073/pnas.2014931117
See companion article:
β-Arrestin2 is a critical component of the GPCR–eNOS signalosome
- May 13, 2020

Brief Report

Open Access
Mobile device data reveal the dynamics in a positive relationship between human mobility and COVID-19 infections
Chenfeng Xiong, Songhua Hu, Mofeng Yang, Weiyu Luo, and Lei Zhang

PNAS November 3, 2020 117 (44) 27087-27089; first published October 15, 2020. https://doi.org/10.1073/pnas.2010836117

Physical Sciences

Applied Physical Sciences
- Open Access
  Prediction and prevention of disproportionally dominant agents in complex networks
  Sandro Claudio Lera, Alex Pentland, and Didier Sornette
  
  PNAS November 3, 2020 117 (44) 27090-27095; first published October 16, 2020. https://doi.org/10.1073/pnas.2003632117
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  Behavior and mechanics of dense microgel suspensions
  Svetoslav V. Nikolov, Alberto Fernandez-Nieves, and Alexander Alexeev
  
  PNAS November 3, 2020 117 (44) 27096-27103; first published October 19, 2020. https://doi.org/10.1073/pnas.2008076117
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  Optical signatures of multifold fermions in the chiral topological semimetal CoSi
  Bing Xu, Zhenyao Fang, Miguel-Ángel Sánchez-Martínez, Jorn W. F. Venderbos, Zhuoliang Ni, Tian Qiu, Kaustuv Manna, Kefeng Wang, Johnpierre Paglione, Christian Bernhard, Claudia Felser, Eugene J. Mele, Adolfo G. Grushin, Andrew M. Rappe, and Liang Wu
  
  PNAS November 3, 2020 117 (44) 27104-27110; first published October 19, 2020. https://doi.org/10.1073/pnas.2010752117
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  Entropy-controlled cross-linking in linker-mediated vitrimers
  Qun-Li Lei, Xiuyang Xia, Juan Yang, Massimo Pica Ciamarra, and Ran Ni
  
  PNAS November 3, 2020 117 (44) 27111-27115; first published October 21, 2020. https://doi.org/10.1073/pnas.2015672117
Biophysics and Computational Biology
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  Broad distributions of transition-path times are fingerprints of multidimensionality of the underlying free energy landscapes
  Rohit Satija, Alexander M. Berezhkovskii, and Dmitrii E. Makarov
  
  PNAS November 3, 2020 117 (44) 27116-27123; first published October 21, 2020. https://doi.org/10.1073/pnas.2008307117
- Open Access
  Phase separation at the nanoscale quantified by dcFCCS
  Sijia Peng, Weiping Li, Yirong Yao, Wenjing Xing, Pilong Li, and Chunlai Chen
  
  PNAS November 3, 2020 117 (44) 27124-27131; first published October 21, 2020. https://doi.org/10.1073/pnas.2008447117
- Open Access
  Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography
  Mateusz Sikora, Utz H. Ermel, Anna Seybold, Michael Kunz, Giulia Calloni, Julian Reitz, R. Martin Vabulas, Gerhard Hummer, and Achilleas S. Frangakis
  
  PNAS November 3, 2020 117 (44) 27132-27140; first published October 16, 2020. https://doi.org/10.1073/pnas.2004563117
Chemistry
- Open Access
  Decoy nanoparticles protect against COVID-19 by concurrently adsorbing viruses and inflammatory cytokines
  From the Cover
  
  Lang Rao, Shuai Xia, Wei Xu, Rui Tian, Guocan Yu, Chenjian Gu, Pan Pan, Qian-Fang Meng, Xia Cai, Di Qu, Lu Lu, Youhua Xie, Shibo Jiang, and Xiaoyuan Chen
  
  PNAS November 3, 2020 117 (44) 27141-27147; first published October 6, 2020. https://doi.org/10.1073/pnas.2014352117
- Open Access
  Plasmonic probing of the adhesion strength of single microbial cells
  Yi-Nan Liu, Zhen-Ting Lv, Wen-Li Lv, and Xian-Wei Liu
  
  PNAS November 3, 2020 117 (44) 27148-27153; first published October 15, 2020. https://doi.org/10.1073/pnas.2010136117
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  Strong sequentially bridged MXene sheets
  Sijie Wan, Xiang Li, Yanlei Wang, Ying Chen, Xi Xie, Rui Yang, Antoni P. Tomsia, Lei Jiang, and Qunfeng Cheng
  
  PNAS November 3, 2020 117 (44) 27154-27161; first published October 21, 2020. https://doi.org/10.1073/pnas.2009432117
- Open Access
  Mapping glycan-mediated galectin-3 interactions by live cell proximity labeling
  Eugene Joeh, Timothy O’Leary, Weichao Li, Richard Hawkins, Jonathan R. Hung, Christopher G. Parker, and Mia L. Huang
  
  PNAS November 3, 2020 117 (44) 27329-27338; first published October 16, 2020. https://doi.org/10.1073/pnas.2009206117
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  Experimentally determined strengths of favorable and unfavorable interactions of amide atoms involved in protein self-assembly in water
  Xian Cheng, Irina A. Shkel, Kevin O’Connor, and M. Thomas Record Jr
  
  PNAS November 3, 2020 117 (44) 27339-27345; first published October 21, 2020. https://doi.org/10.1073/pnas.2012481117
- Open Access
  Unexpected specificity within dynamic transcriptional protein–protein complexes
  Matthew J. Henley, Brian M. Linhares, Brittany S. Morgan, Tomasz Cierpicki, Carol A. Fierke, and Anna K. Mapp
  
  PNAS November 3, 2020 117 (44) 27346-27353; first published October 19, 2020. https://doi.org/10.1073/pnas.2013244117
Computer Sciences
- Open Access
  Overparameterized neural networks implement associative memory
  Adityanarayanan Radhakrishnan, Mikhail Belkin, and Caroline Uhler
  
  PNAS November 3, 2020 117 (44) 27162-27170; first published October 16, 2020. https://doi.org/10.1073/pnas.2005013117
Earth, Atmospheric, and Planetary Sciences
- Open Access
  Annually resolved Atlantic sea surface temperature variability over the past 2,900 y
  Francois Lapointe, Raymond S. Bradley, Pierre Francus, Nicholas L. Balascio, Mark B. Abbott, Joseph S. Stoner, Guillaume St-Onge, Arnaud De Coninck, and Thibault Labarre
  
  PNAS November 3, 2020 117 (44) 27171-27178; first published October 12, 2020. https://doi.org/10.1073/pnas.2014166117
- Open Access
  Chaos in a simple model of a delta network
  Gerard Salter, Vaughan R. Voller, and Chris Paola
  
  PNAS November 3, 2020 117 (44) 27179-27187; first published October 19, 2020. https://doi.org/10.1073/pnas.2010416117
Engineering
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  Superhydrophobic surfaces for extreme environmental conditions
  Henry Lambley, Thomas M. Schutzius, and Dimos Poulikakos
  
  PNAS November 3, 2020 117 (44) 27188-27194; first published October 19, 2020. https://doi.org/10.1073/pnas.2008775117
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  Design principles for self-forming interfaces enabling stable lithium-metal anodes
  Yingying Zhu, Vikram Pande, Linsen Li, Bohua Wen, Menghsuan Sam Pan, David Wang, Zi-Feng Ma, Venkatasubramanian Viswanathan, and Yet-Ming Chiang
  
  PNAS November 3, 2020 117 (44) 27195-27203; first published October 15, 2020. https://doi.org/10.1073/pnas.2001923117
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  A 3D-printed molecular ferroelectric metamaterial
  Yong Hu, Zipeng Guo, Andrew Ragonese, Taishan Zhu, Saurabh Khuje, Changning Li, Jeffrey C. Grossman, Chi Zhou, Mostafa Nouh, and Shenqiang Ren
  
  PNAS November 3, 2020 117 (44) 27204-27210; first published October 19, 2020. https://doi.org/10.1073/pnas.2013934117
Environmental Sciences
- Open Access
  Changing nutrient cycling in Lake Baikal, the world’s oldest lake
  George E. A. Swann, Virginia N. Panizzo, Sebastiano Piccolroaz, Vanessa Pashley, Matthew S. A. Horstwood, Sarah Roberts, Elena Vologina, Natalia Piotrowska, Michael Sturm, Andre Zhdanov, Nikolay Granin, Charlotte Norman, Suzanne McGowan, and Anson W. Mackay
  
  PNAS November 3, 2020 117 (44) 27211-27217; first published October 19, 2020. https://doi.org/10.1073/pnas.2013181117
Physics
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  Funneled energy landscape unifies principles of protein binding and evolution
  Zhiqiang Yan and Jin Wang
  
  PNAS November 3, 2020 117 (44) 27218-27223; first published October 16, 2020. https://doi.org/10.1073/pnas.2013822117
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  Magnetized topological insulator multilayers
  Chao Lei, Shu Chen, and Allan H. MacDonald
  
  PNAS November 3, 2020 117 (44) 27224-27230; first published October 19, 2020. https://doi.org/10.1073/pnas.2014004117
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  Tuning the quantumness of simple Bose systems: A universal phase diagram
  Youssef Kora, Massimo Boninsegni, Dam Thanh Son, and Shiwei Zhang
  
  PNAS November 3, 2020 117 (44) 27231-27237; first published October 21, 2020. https://doi.org/10.1073/pnas.2017646117
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  Extremely small twist elastic constants in lyotropic nematic liquid crystals
  Clarissa F. Dietrich, Peter J. Collings, Thomas Sottmann, Per Rudquist, and Frank Giesselmann
  
  PNAS November 3, 2020 117 (44) 27238-27244; first published October 16, 2020. https://doi.org/10.1073/pnas.1922275117
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  Multiphase magnetism in Yb₂Ti₂O₇
  From the Cover
  
  Allen Scheie, Jonas Kindervater, Shu Zhang, Hitesh J. Changlani, Gabriele Sala, Georg Ehlers, Andre Heinemann, Gregory S. Tucker, Seyed M. Koohpayeh, and Collin Broholm
  
  PNAS November 3, 2020 117 (44) 27245-27254; first published October 23, 2020. https://doi.org/10.1073/pnas.2008791117
  
  See companion article:
  On the way to understanding Yb₂Ti₂O₇
  - Nov 09, 2020

Biological Sciences

Applied Biological Sciences
- Open Access
  Liquid drop of DNA libraries reveals total genome information
  Stanislav S. Terekhov, Igor E. Eliseev, Leyla A. Ovchinnikova, Marsel R. Kabilov, Andrey D. Prjibelski, Alexey E. Tupikin, Ivan V. Smirnov, Alexey A. Belogurov Jr, Konstantin V. Severinov, Yakov A. Lomakin, Sidney Altman, and Alexander G. Gabibov
  
  PNAS November 3, 2020 117 (44) 27300-27306; first published October 21, 2020. https://doi.org/10.1073/pnas.2017138117
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  In vitro evolution of antibody affinity via insertional scanning mutagenesis of an entire antibody variable region
  Kalliopi Skamaki, Stephane Emond, Matthieu Chodorge, John Andrews, D. Gareth Rees, Daniel Cannon, Bojana Popovic, Andrew Buchanan, Ralph R. Minter, and Florian Hollfelder
  
  PNAS November 3, 2020 117 (44) 27307-27318; first published October 16, 2020. https://doi.org/10.1073/pnas.2002954117
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  PLA2G6 guards placental trophoblasts against ferroptotic injury
  Ofer Beharier, Vladimir A. Tyurin, Julie P. Goff, Jennifer Guerrero-Santoro, Kazuhiro Kajiwara, Tianjiao Chu, Yulia Y. Tyurina, Claudette M. St Croix, Callen T. Wallace, Samuel Parry, W. Tony Parks, Valerian E. Kagan, and Yoel Sadovsky
  
  PNAS November 3, 2020 117 (44) 27319-27328; first published October 21, 2020. https://doi.org/10.1073/pnas.2009201117
Biochemistry
- Open Access
  Mapping glycan-mediated galectin-3 interactions by live cell proximity labeling
  Eugene Joeh, Timothy O’Leary, Weichao Li, Richard Hawkins, Jonathan R. Hung, Christopher G. Parker, and Mia L. Huang
  
  PNAS November 3, 2020 117 (44) 27329-27338; first published October 16, 2020. https://doi.org/10.1073/pnas.2009206117
- You have access
  Experimentally determined strengths of favorable and unfavorable interactions of amide atoms involved in protein self-assembly in water
  Xian Cheng, Irina A. Shkel, Kevin O’Connor, and M. Thomas Record Jr
  
  PNAS November 3, 2020 117 (44) 27339-27345; first published October 21, 2020. https://doi.org/10.1073/pnas.2012481117
- Open Access
  Unexpected specificity within dynamic transcriptional protein–protein complexes
  Matthew J. Henley, Brian M. Linhares, Brittany S. Morgan, Tomasz Cierpicki, Carol A. Fierke, and Anna K. Mapp
  
  PNAS November 3, 2020 117 (44) 27346-27353; first published October 19, 2020. https://doi.org/10.1073/pnas.2013244117
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  Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression
  Siddhant U. Jain, Sima Khazaei, Dylan M. Marchione, Stefan M. Lundgren, Xiaoshi Wang, Daniel N. Weinberg, Shriya Deshmukh, Nikoleta Juretic, Chao Lu, C. David Allis, Benjamin A. Garcia, Nada Jabado, and Peter W. Lewis
  
  PNAS November 3, 2020 117 (44) 27354-27364; first published October 16, 2020. https://doi.org/10.1073/pnas.2006076117
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  DOT1L-controlled cell-fate determination and transcription elongation are independent of H3K79 methylation
  Kaixiang Cao, Michal Ugarenko, Patrick A. Ozark, Juan Wang, Stacy A. Marshall, Emily J. Rendleman, Kaiwei Liang, Lu Wang, Lihua Zou, Edwin R. Smith, Feng Yue, and Ali Shilatifard
  
  PNAS November 3, 2020 117 (44) 27365-27373; first published October 19, 2020. https://doi.org/10.1073/pnas.2001075117
Biophysics and Computational Biology
- You have access
  Broad distributions of transition-path times are fingerprints of multidimensionality of the underlying free energy landscapes
  Rohit Satija, Alexander M. Berezhkovskii, and Dmitrii E. Makarov
  
  PNAS November 3, 2020 117 (44) 27116-27123; first published October 21, 2020. https://doi.org/10.1073/pnas.2008307117
- Open Access
  Phase separation at the nanoscale quantified by dcFCCS
  Sijia Peng, Weiping Li, Yirong Yao, Wenjing Xing, Pilong Li, and Chunlai Chen
  
  PNAS November 3, 2020 117 (44) 27124-27131; first published October 21, 2020. https://doi.org/10.1073/pnas.2008447117
- You have access
  Funneled energy landscape unifies principles of protein binding and evolution
  Zhiqiang Yan and Jin Wang
  
  PNAS November 3, 2020 117 (44) 27218-27223; first published October 16, 2020. https://doi.org/10.1073/pnas.2013822117
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  Three-dimensional deconvolution processing for STEM cryotomography
  Barnali Waugh, Sharon G. Wolf, Deborah Fass, Eric Branlund, Zvi Kam, John W. Sedat, and Michael Elbaum
  
  PNAS November 3, 2020 117 (44) 27374-27380; first published October 19, 2020. https://doi.org/10.1073/pnas.2000700117
- Open Access
  Identify potent SARS-CoV-2 main protease inhibitors via accelerated free energy perturbation-based virtual screening of existing drugs
  Zhe Li, Xin Li, Yi-You Huang, Yaoxing Wu, Runduo Liu, Lingli Zhou, Yuxi Lin, Deyan Wu, Lei Zhang, Hao Liu, Ximing Xu, Kunqian Yu, Yuxia Zhang, Jun Cui, Chang-Guo Zhan, Xin Wang, and Hai-Bin Luo
  
  PNAS November 3, 2020 117 (44) 27381-27387; first published October 13, 2020. https://doi.org/10.1073/pnas.2010470117
  
  See companion article:
  Reply to Ma and Wang: Reliability of various in vitro activity assays on SARS-CoV-2 main protease inhibitors
  - Feb 10, 2021
  
  Reply to Behnam and Klein: Potential role of the His-tag in C-terminal His-tagged SARS-CoV-2 main protease
  - Sep 02, 2021
Cell Biology
- Open Access
  Computationally enhanced quantitative phase microscopy reveals autonomous oscillations in mammalian cell growth
  Xili Liu, Seungeun Oh, Leonid Peshkin, and Marc W. Kirschner
  
  PNAS November 3, 2020 117 (44) 27388-27399; first published October 21, 2020. https://doi.org/10.1073/pnas.2002152117
- Open Access
  Macropinocytosis-mediated membrane recycling drives neural crest migration by delivering F-actin to the lamellipodium
  Yuwei Li, Walter G. Gonzalez, Andrey Andreev, Weiyi Tang, Shashank Gandhi, Alexandre Cunha, David Prober, Carlos Lois, and Marianne E. Bronner
  
  PNAS November 3, 2020 117 (44) 27400-27411; first published October 21, 2020. https://doi.org/10.1073/pnas.2007229117
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  Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression
  Peng-bo Yang, Pei-pei Hou, Fu-yuan Liu, Wen-bin Hong, Hang-zi Chen, Xiao-yu Sun, Peng Li, Yi Zhang, Cui-yu Ju, Li-juan Luo, Sheng-fu Wu, Jia-xin Zhou, Zhi-jing Wang, Jian-ping He, Li Li, Tong-Jin Zhao, Xianming Deng, Tianwei Lin, and Qiao Wu
  
  PNAS November 3, 2020 117 (44) 27412-27422; first published October 21, 2020. https://doi.org/10.1073/pnas.2002997117
- Open Access
  Collective cancer cell invasion requires RNA accumulation at the invasive front
  George Chrisafis, Tianhong Wang, Konstadinos Moissoglu, Alexander N. Gasparski, Yeap Ng, Roberto Weigert, Stephen J. Lockett, and Stavroula Mili
  
  PNAS November 3, 2020 117 (44) 27423-27434; first published October 15, 2020. https://doi.org/10.1073/pnas.2010872117
Developmental Biology
- Open Access
  B3GALT5 knockout alters glycosphingolipid profile and facilitates transition to human naïve pluripotency
  Ruey-Jen Lin, Ming-Wei Kuo, Bei-Chia Yang, Hsiu-Hui Tsai, Kowa Chen, Jing-Rong Huang, Yun-Shien Lee, Alice L. Yu, and John Yu
  
  PNAS November 3, 2020 117 (44) 27435-27444; first published October 21, 2020. https://doi.org/10.1073/pnas.2003155117
Ecology
- Open Access
  Diatom modulation of select bacteria through use of two unique secondary metabolites
  Ahmed A. Shibl, Ashley Isaac, Michael A. Ochsenkühn, Anny Cárdenas, Cong Fei, Gregory Behringer, Marc Arnoux, Nizar Drou, Miraflor P. Santos, Kristin C. Gunsalus, Christian R. Voolstra, and Shady A. Amin
  
  PNAS November 3, 2020 117 (44) 27445-27455; first published October 16, 2020. https://doi.org/10.1073/pnas.2012088117
- Open Access
  Seasonality and uncertainty in global COVID-19 growth rates
  Cory Merow and Mark C. Urban
  
  PNAS November 3, 2020 117 (44) 27456-27464; first published October 13, 2020. https://doi.org/10.1073/pnas.2008590117
Evolution
- Open Access
  Revealing mechanisms of mating plug function under sexual selection
  Paula Stockley, Catarina Franco, Amy J. Claydon, Amanda Davidson, Dean E. Hammond, Philip J. Brownridge, Jane L. Hurst, and Robert J. Beynon
  
  PNAS November 3, 2020 117 (44) 27465-27473; first published October 19, 2020. https://doi.org/10.1073/pnas.1920526117
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  A release from developmental bias accelerates morphological diversification in butterfly eyespots
  Oskar Brattström, Kwaku Aduse-Poku, Erik van Bergen, Vernon French, and Paul M. Brakefield
  
  PNAS November 3, 2020 117 (44) 27474-27480; first published October 22, 2020. https://doi.org/10.1073/pnas.2008253117
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  Toxin-like neuropeptides in the sea anemone Nematostella unravel recruitment from the nervous system to venom
  Maria Y. Sachkova, Morani Landau, Joachim M. Surm, Jason Macrander, Shir A. Singer, Adam M. Reitzel, and Yehu Moran
  
  PNAS November 3, 2020 117 (44) 27481-27492; first published October 15, 2020. https://doi.org/10.1073/pnas.2011120117
Genetics
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  Nucleosome Positioning Regulates the Establishment, Stability, and Inheritance of Heterochromatin in Saccharomyces cerevisiae
  Daniel S. Saxton and Jasper Rine
  
  PNAS November 3, 2020 117 (44) 27493-27501; first published October 19, 2020. https://doi.org/10.1073/pnas.2004111117
Immunology and Inflammation
- Open Access
  Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling
  Denis Chang, Aaron T. Whiteley, Katlynn Bugda Gwilt, Wayne I. Lencer, John J. Mekalanos, and Jay R. Thiagarajah
  
  PNAS November 3, 2020 117 (44) 27502-27508; first published October 21, 2020. https://doi.org/10.1073/pnas.2015919117
- Open Access
  Bifidobacterium alters the gut microbiota and modulates the functional metabolism of T regulatory cells in the context of immune checkpoint blockade
  Shan Sun, Lingjie Luo, Wenhua Liang, Qian Yin, Jing Guo, Anthony M. Rush, Zhibao Lv, Qiming Liang, Michael A. Fischbach, Justin L. Sonnenburg, Dylan Dodd, Mark M. Davis, and Feng Wang
  
  PNAS November 3, 2020 117 (44) 27509-27515; first published October 19, 2020. https://doi.org/10.1073/pnas.1921223117
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  Interactions between host genetics and gut microbiota determine susceptibility to CNS autoimmunity
  From the Cover
  
  Theresa L. Montgomery, Axel Künstner, Josephine J. Kennedy, Qian Fang, Lori Asarian, Rachel Culp-Hill, Angelo D’Alessandro, Cory Teuscher, Hauke Busch, and Dimitry N. Krementsov
  
  PNAS November 3, 2020 117 (44) 27516-27527; first published October 19, 2020. https://doi.org/10.1073/pnas.2002817117
  
  See companion article:
  The microbiome requires a genetically susceptible host to induce central nervous system autoimmunity
  - Oct 29, 2020
- Open Access
  Selective tumor antigen vaccine delivery to human CD169⁺ antigen-presenting cells using ganglioside-liposomes
  Alsya J. Affandi, Joanna Grabowska, Katarzyna Olesek, Miguel Lopez Venegas, Arnaud Barbaria, Ernesto Rodríguez, Patrick P. G. Mulder, Helen J. Pijffers, Martino Ambrosini, Hakan Kalay, Tom O’Toole, Eline S. Zwart, Geert Kazemier, Kamran Nazmi, Floris J. Bikker, Johannes Stöckl, Alfons J. M. van den Eertwegh, Tanja D. de Gruijl, Gert Storm, Yvette van Kooyk, and Joke M. M. den Haan
  
  PNAS November 3, 2020 117 (44) 27528-27539; first published October 16, 2020. https://doi.org/10.1073/pnas.2006186117
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  IL-36R signaling integrates innate and adaptive immune-mediated protection against enteropathogenic bacteria
  Vu L. Ngo, Hirohito Abo, Michal Kuczma, Edyta Szurek, Nora Moore, Oscar Medina-Contreras, Asma Nusrat, Didier Merlin, Andrew T. Gewirtz, Leszek Ignatowicz, and Timothy L. Denning
  
  PNAS November 3, 2020 117 (44) 27540-27548; first published October 21, 2020. https://doi.org/10.1073/pnas.2004484117
Medical Sciences
- Open Access
  Decoy nanoparticles protect against COVID-19 by concurrently adsorbing viruses and inflammatory cytokines
  From the Cover
  
  Lang Rao, Shuai Xia, Wei Xu, Rui Tian, Guocan Yu, Chenjian Gu, Pan Pan, Qian-Fang Meng, Xia Cai, Di Qu, Lu Lu, Youhua Xie, Shibo Jiang, and Xiaoyuan Chen
  
  PNAS November 3, 2020 117 (44) 27141-27147; first published October 6, 2020. https://doi.org/10.1073/pnas.2014352117
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  Prenatal and early-life exposure to the Great Chinese Famine increased the risk of tuberculosis in adulthood across two generations
  From the Cover
  
  Qu Cheng, Robert Trangucci, Kristin N. Nelson, Wenjiang Fu, Philip A. Collender, Jennifer R. Head, Christopher M. Hoover, Nicholas K. Skaff, Ting Li, Xintong Li, Yue You, Liqun Fang, Song Liang, Changhong Yang, Jin’ge He, Jonathan L. Zelner, and Justin V. Remais
  
  PNAS November 3, 2020 117 (44) 27549-27555; first published October 19, 2020. https://doi.org/10.1073/pnas.2008336117
  
  See companion article:
  Reply to Li et al.: Estimate of the association between TB risk and famine intensity is robust to various famine intensity estimators
  - Apr 16, 2021
- You have access
  MNK2 governs the macrophage antiinflammatory phenotype
  Margarita Bartish, Dongmei Tong, Yangxun Pan, Majken Wallerius, Hui Liu, Johannes Ristau, Sabrina de Souza Ferreira, Tatjana Wallmann, Vincent van Hoef, Laia Masvidal, Thomas Kerzel, Anne-Laure Joly, Christophe Goncalves, Samuel E. J. Preston, Talin Ebrahimian, Christina Seitz, Jonas Bergh, Kristian Pietras, Stephanie Lehoux, Luigi Naldini, John Andersson, Mario Leonardo Squadrito, Sonia V. del Rincón, Ola Larsson, and Charlotte Rolny
  
  PNAS November 3, 2020 117 (44) 27556-27565; first published October 19, 2020. https://doi.org/10.1073/pnas.1920377117
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  Polymerase δ promotes chromosomal rearrangements and imprecise double-strand break repair
  Jacob V. Layer, Lydie Debaize, Alexandria Van Scoyk, Nealia C. House, Alexander J. Brown, Yunpeng Liu, Kristen E. Stevenson, Michael Hemann, Steven A. Roberts, Brendan D. Price, David M. Weinstock, and Tovah A. Day
  
  PNAS November 3, 2020 117 (44) 27566-27577; first published October 19, 2020. https://doi.org/10.1073/pnas.2014176117
Microbiology
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  The cytokine MIF controls daily rhythms of symbiont nutrition in an animal–bacterial association
  Eric J. Koch, Clotilde Bongrand, Brittany D. Bennett, Susannah Lawhorn, Silvia Moriano-Gutierrez, Marko Pende, Karim Vadiwala, Hans-Ulrich Dodt, Florian Raible, William Goldman, Edward G. Ruby, and Margaret McFall-Ngai
  
  PNAS November 3, 2020 117 (44) 27578-27586; first published October 16, 2020. https://doi.org/10.1073/pnas.2016864117
- Open Access
  Global diversity of microbial communities in marine sediment
  Tatsuhiko Hoshino, Hideyuki Doi, Go-Ichiro Uramoto, Lars Wörmer, Rishi R. Adhikari, Nan Xiao, Yuki Morono, Steven D’Hondt, Kai-Uwe Hinrichs, and Fumio Inagaki
  
  PNAS November 3, 2020 117 (44) 27587-27597; first published October 19, 2020. https://doi.org/10.1073/pnas.1919139117
- Open Access
  Stimulator of interferon genes (STING) is an essential proviral host factor for human rhinovirus species A and C
  Kevin L. McKnight, Karen V. Swanson, Kathryn Austgen, Cindy Richards, Jonathan K. Mitchell, David R. McGivern, Ethan Fritch, John Johnson, Katja Remlinger, Michal Magid-Slav, Maryna Kapustina, Shihyun You, and Stanley M. Lemon
  
  PNAS November 3, 2020 117 (44) 27598-27607; first published October 15, 2020. https://doi.org/10.1073/pnas.2014940117
- Open Access
  Synthetic gene-regulatory networks in the opportunistic human pathogen Streptococcus pneumoniae
  Robin A. Sorg, Clement Gallay, Laurye Van Maele, Jean-Claude Sirard, and Jan-Willem Veening
  
  PNAS November 3, 2020 117 (44) 27608-27619; first published October 21, 2020. https://doi.org/10.1073/pnas.1920015117
- Open Access
  Defining principles that influence antimicrobial peptide activity against capsulated Klebsiella pneumoniae
  Renee M. Fleeman, Luis A. Macias, Jennifer S. Brodbelt, and Bryan W. Davies
  
  PNAS November 3, 2020 117 (44) 27620-27626; first published October 21, 2020. https://doi.org/10.1073/pnas.2007036117
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  Mosquito metabolomics reveal that dengue virus replication requires phospholipid reconfiguration via the remodeling cycle
  Thomas Vial, Wei-Lian Tan, Eric Deharo, Dorothée Missé, Guillaume Marti, and Julien Pompon
  
  PNAS November 3, 2020 117 (44) 27627-27636; first published October 21, 2020. https://doi.org/10.1073/pnas.2015095117
- Open Access
  Structural basis of Chikungunya virus inhibition by monoclonal antibodies
  Qun Fei Zhou, Julie M. Fox, James T. Earnest, Thiam-Seng Ng, Arthur S. Kim, Guntur Fibriansah, Victor A. Kostyuchenko, Jian Shi, Bo Shu, Michael S. Diamond, and Shee-Mei Lok
  
  PNAS November 3, 2020 117 (44) 27637-27645; first published October 21, 2020. https://doi.org/10.1073/pnas.2008051117
Neuroscience
- Open Access
  Formation of global self-beliefs in the human brain
  Marion Rouault and Stephen M. Fleming
  
  PNAS November 3, 2020 117 (44) 27268-27276; first published October 15, 2020. https://doi.org/10.1073/pnas.2003094117
- Open Access
  Cell type-specific lipid storage changes in Parkinson’s disease patient brains are recapitulated by experimental glycolipid disturbance
  Oeystein Roed Brekk, Jonathan R. Honey, Seungil Lee, Penelope J. Hallett, and Ole Isacson
  
  PNAS November 3, 2020 117 (44) 27646-27654; first published October 15, 2020. https://doi.org/10.1073/pnas.2003021117
- Open Access
  Forelimb force direction and magnitude independently controlled by spinal modules in the macaque
  Amit Yaron, David Kowalski, Hiroaki Yaguchi, Tomohiko Takei, and Kazuhiko Seki
  
  PNAS November 3, 2020 117 (44) 27655-27666; first published October 15, 2020. https://doi.org/10.1073/pnas.1919253117
- Open Access
  P7C3-A20 treatment one year after TBI in mice repairs the blood–brain barrier, arrests chronic neurodegeneration, and restores cognition
  Edwin Vázquez-Rosa, Min-Kyoo Shin, Matasha Dhar, Kalyani Chaubey, Coral J. Cintrón-Pérez, Xinmiao Tang, Xudong Liao, Emiko Miller, Yeojung Koh, Sarah Barker, Kathryn Franke, Danyel R. Crosby, Rachel Schroeder, Josie Emery, Terry C. Yin, Hisashi Fujioka, James D. Reynolds, Matthew M. Harper, Mukesh K. Jain, and Andrew A. Pieper
  
  PNAS November 3, 2020 117 (44) 27667-27675; first published October 21, 2020. https://doi.org/10.1073/pnas.2010430117
Physiology
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  Liquid-liquid phase separation promotes animal desiccation tolerance
  Clinton Belott, Brett Janis, and Michael A. Menze
  
  PNAS November 3, 2020 117 (44) 27676-27684; first published October 19, 2020. https://doi.org/10.1073/pnas.2014463117
Plant Biology
- Open Access
  N-glycosylation shields Phytophthora sojae apoplastic effector PsXEG1 from a specific host aspartic protease
  Yeqiang Xia, Zhenchuan Ma, Min Qiu, Baodian Guo, Qi Zhang, Haibin Jiang, Baiyu Zhang, Yachun Lin, Mingrun Xuan, Liang Sun, Haidong Shu, Junhua Xiao, Wenwu Ye, Yan Wang, Yiming Wang, Suomeng Dong, Brett M. Tyler, and Yuanchao Wang
  
  PNAS November 3, 2020 117 (44) 27685-27693; first published October 20, 2020. https://doi.org/10.1073/pnas.2012149117
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  The UBC27–AIRP3 ubiquitination complex modulates ABA signaling by promoting the degradation of ABI1 in Arabidopsis
  Wenbo Pan, Baoying Lin, Xiaoyuan Yang, Lijing Liu, Ran Xia, Jigang Li, Yaorong Wu, and Qi Xie
  
  PNAS November 3, 2020 117 (44) 27694-27702; first published October 19, 2020. https://doi.org/10.1073/pnas.2007366117
Population Biology
- Open Access
  Acceleration of plague outbreaks in the second pandemic
  David J. D. Earn, Junling Ma, Hendrik Poinar, Jonathan Dushoff, and Benjamin M. Bolker
  
  PNAS November 3, 2020 117 (44) 27703-27711; first published October 19, 2020. https://doi.org/10.1073/pnas.2004904117
Psychological and Cognitive Sciences
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  Economic hardship and mental health complaints during COVID-19
  Dirk Witteveen and Eva Velthorst
  
  PNAS November 3, 2020 117 (44) 27277-27284; first published October 12, 2020. https://doi.org/10.1073/pnas.2009609117
- Open Access
  Neurotypical individuals fail to understand action vitality form in children with autism spectrum disorder
  Luca Casartelli, Alessandra Federici, Lucia Fumagalli, Ambra Cesareo, Monica Nicoli, Luca Ronconi, Andrea Vitale, Massimo Molteni, Giacomo Rizzolatti, and Corrado Sinigaglia
  
  PNAS November 3, 2020 117 (44) 27712-27718; first published October 21, 2020. https://doi.org/10.1073/pnas.2011311117
- Open Access
  Model-free decision making is prioritized when learning to avoid harming others
  Patricia L. Lockwood, Miriam C. Klein-Flügge, Ayat Abdurahman, and Molly J. Crockett
  
  PNAS November 3, 2020 117 (44) 27719-27730; first published October 14, 2020. https://doi.org/10.1073/pnas.2010890117
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  Conservative and liberal attitudes drive polarized neural responses to political content
  From the Cover
  
  Yuan Chang Leong, Janice Chen, Robb Willer, and Jamil Zaki
  
  PNAS November 3, 2020 117 (44) 27731-27739; first published October 20, 2020. https://doi.org/10.1073/pnas.2008530117
  
  See companion article:
  Neural polarization and routes to depolarization
  - Nov 02, 2020

Corrections

You have access
Correction for Ishida et al., Novel electronic nematicity in heavily hole-doped iron pnictide superconductors
PNAS November 3, 2020 117 (44) 27740; first published October 12, 2020. https://doi.org/10.1073/pnas.2019840117
You have access
Correction for Escobar et al., BCG vaccine protection from severe coronavirus disease 2019 (COVID-19)
PNAS November 3, 2020 117 (44) 27741-27742; first published October 12, 2020. https://doi.org/10.1073/pnas.2019438117
You have access
Correction for Sim et al., High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D
PNAS November 3, 2020 117 (44) 27743-27744; first published October 19, 2020. https://doi.org/10.1073/pnas.2019815117
You have access
Correction for Shi et al., PIWIL1 promotes gastric cancer via a piRNA-independent mechanism
PNAS November 3, 2020 117 (44) 27745-27746; first published October 12, 2020. https://doi.org/10.1073/pnas.2019929117

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