Table of Contents

Biological Sciences

• Applied Biological Sciences

  • Open Access

    Elucidating aromatic acid tolerance at low pH in Saccharomyces cerevisiae using adaptive laboratory evolution

    Rui Pereira, Elsayed T. Mohamed, Mohammad S. Radi, Markus J. Herrgård, Adam M. Feist, Jens Nielsen, and Yun Chen

    PNAS November 10, 2020 117 (45) 27954-27961; first published October 26, 2020. https://doi.org/10.1073/pnas.2013044117

• Biochemistry

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    A far-red cyanobacteriochrome lineage specific for verdins

    Marcus V. Moreno, Nathan C. Rockwell, Manuel Mora, Andrew J. Fisher, and J. Clark Lagarias

    PNAS November 10, 2020 117 (45) 27962-27970; first published October 26, 2020. https://doi.org/10.1073/pnas.2016047117
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    The human CRY1 tail controls circadian timing by regulating its association with CLOCK:BMAL1

    Gian Carlo G. Parico, Ivette Perez, Jennifer L. Fribourgh, Britney N. Hernandez, Hsiau-Wei Lee, and Carrie L. Partch

    PNAS November 10, 2020 117 (45) 27971-27979; first published October 26, 2020. https://doi.org/10.1073/pnas.1920653117
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    Mcl-1 and Bok transmembrane domains: Unexpected players in the modulation of apoptosis

    Estefanía Lucendo, Mónica Sancho, Fabio Lolicato, Matti Javanainen, Waldemar Kulig, Diego Leiva, Gerard Duart, Vicente Andreu-Fernández, Ismael Mingarro, and Mar Orzáez

    PNAS November 10, 2020 117 (45) 27980-27988; first published October 22, 2020. https://doi.org/10.1073/pnas.2008885117
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    Reversible autoinhibitory regulation of Escherichia coli metallopeptidase BepA for selective β-barrel protein degradation

    Yasushi Daimon, Shin-ichiro Narita, Ryoji Miyazaki, Yohei Hizukuri, Hiroyuki Mori, Yoshiki Tanaka, Tomoya Tsukazaki, and Yoshinori Akiyama

    PNAS November 10, 2020 117 (45) 27989-27996; first published October 22, 2020. https://doi.org/10.1073/pnas.2010301117
  • Open Access

    Amyloid formation of fish β-parvalbumin involves primary nucleation triggered by disulfide-bridged protein dimers

    Tony E. R. Werner, David Bernson, Elin K. Esbjörner, Sandra Rocha, and Pernilla Wittung-Stafshede

    PNAS November 10, 2020 117 (45) 27997-28004; first published October 22, 2020. https://doi.org/10.1073/pnas.2015503117
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    Multistep substrate binding and engagement by the AAA+ ClpXP protease

    Reuben A. Saunders, Benjamin M. Stinson, Tania A. Baker, and Robert T. Sauer

    PNAS November 10, 2020 117 (45) 28005-28013; first published October 26, 2020. https://doi.org/10.1073/pnas.2010804117

• Biophysics and Computational Biology

  • Open Access

    Origin of exponential growth in nonlinear reaction networks

    Wei-Hsiang Lin, Edo Kussell, Lai-Sang Young, and Christine Jacobs-Wagner

    PNAS November 10, 2020 117 (45) 27795-27804; first published October 22, 2020. https://doi.org/10.1073/pnas.2013061117
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    Multistep substrate binding and engagement by the AAA+ ClpXP protease

    Reuben A. Saunders, Benjamin M. Stinson, Tania A. Baker, and Robert T. Sauer

    PNAS November 10, 2020 117 (45) 28005-28013; first published October 26, 2020. https://doi.org/10.1073/pnas.2010804117
  • Open Access

    Visualization of the HIV-1 Env glycan shield across scales

    Zachary T. Berndsen, Srirupa Chakraborty, Xiaoning Wang, Christopher A. Cottrell, Jonathan L. Torres, Jolene K. Diedrich, Cesar A. López, John R. Yates III, Marit J. van Gils, James C. Paulson, Sandrasegaram Gnanakaran, and Andrew B. Ward

    PNAS November 10, 2020 117 (45) 28014-28025; first published October 22, 2020. https://doi.org/10.1073/pnas.2000260117
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    SurA is a cryptically grooved chaperone that expands unfolded outer membrane proteins

    Dagan C. Marx, Ashlee M. Plummer, Anneliese M. Faustino, Taylor Devlin, Michaela A. Roskopf, Mathis J. Leblanc, Henry J. Lessen, Barbara T. Amann, Patrick J. Fleming, Susan Krueger, Stephen D. Fried, and Karen G. Fleming

    PNAS November 10, 2020 117 (45) 28026-28035; first published October 22, 2020. https://doi.org/10.1073/pnas.2008175117
  • Open Access

    The role of Ca²⁺ and protein scaffolding in the formation of nature’s water oxidizing complex

    Anton P. Avramov, Hong J. Hwang, and Robert L. Burnap

    PNAS November 10, 2020 117 (45) 28036-28045; first published October 26, 2020. https://doi.org/10.1073/pnas.2011315117
  • Open Access

    Engineered ACE2 receptor traps potently neutralize SARS-CoV-2

    Anum Glasgow, Jeff Glasgow, Daniel Limonta, Paige Solomon, Irene Lui, Yang Zhang, Matthew A. Nix, Nicholas J. Rettko, Shoshana Zha, Rachel Yamin, Kevin Kao, Oren S. Rosenberg, Jeffrey V. Ravetch, Arun P. Wiita, Kevin K. Leung, Shion A. Lim, Xin X. Zhou, Tom C. Hobman, Tanja Kortemme, and James A. Wells

    PNAS November 10, 2020 117 (45) 28046-28055; first published October 22, 2020. https://doi.org/10.1073/pnas.2016093117

• Cell Biology

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    PtdIns(3,4,5)P₃-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis

    Nuthasuda Srijakotre, Heng-Jia Liu, Max Nobis, Joey Man, Hon Yan Kelvin Yip, Antonella Papa, Helen E. Abud, Kurt I. Anderson, Heidi C. E. Welch, Tony Tiganis, Paul Timpson, Catriona A. McLean, Lisa M. Ooms, and Christina A. Mitchell

    PNAS November 10, 2020 117 (45) 28056-28067; first published October 23, 2020. https://doi.org/10.1073/pnas.2006445117
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    Targeted CRISPR screening identifies PRMT5 as synthetic lethality combinatorial target with gemcitabine in pancreatic cancer cells

    Xiaolong Wei, Jiekun Yang, Sara J. Adair, Harun Ozturk, Cem Kuscu, Kyung Yong Lee, William J. Kane, Patrick E. O’Hara, Denis Liu, Yusuf Mert Demirlenk, Alaa Hamdi Habieb, Ebru Yilmaz, Anindya Dutta, Todd W. Bauer, and Mazhar Adli

    PNAS November 10, 2020 117 (45) 28068-28079; first published October 23, 2020. https://doi.org/10.1073/pnas.2009899117
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    Identification of a degradation signal at the carboxy terminus of SREBP2: A new role for this domain in cholesterol homeostasis

    Daniel L. Kober, Shimeng Xu, Shili Li, Bilkish Bajaj, Guosheng Liang, Daniel M. Rosenbaum, and Arun Radhakrishnan

    PNAS November 10, 2020 117 (45) 28080-28091; first published October 26, 2020. https://doi.org/10.1073/pnas.2018578117
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    RNA-binding protein DDX3 mediates posttranscriptional regulation of androgen receptor: A mechanism of castration resistance

    Jordan E. Vellky, Sean T. McSweeney, Emily A. Ricke, and William A. Ricke

    PNAS November 10, 2020 117 (45) 28092-28101; first published October 26, 2020. https://doi.org/10.1073/pnas.2008479117
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    Myelination of peripheral nerves is controlled by PI4KB through regulation of Schwann cell Golgi function

    • From the Cover

    Takashi Baba, Alejandro Alvarez-Prats, Yeun Ju Kim, Daniel Abebe, Steve Wilson, Zane Aldworth, Mark A. Stopfer, John Heuser, and Tamas Balla

    PNAS November 10, 2020 117 (45) 28102-28113; first published October 26, 2020. https://doi.org/10.1073/pnas.2007432117

    See companion article:

    • A Golgi-associated lipid kinase controls peripheral nerve myelination

      - Nov 13, 2020
  • Open Access

    USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L–SMAD pathway

    Tao Zhang, Goran Periz, Yu-Ning Lu, and Jiou Wang

    PNAS November 10, 2020 117 (45) 28114-28125; first published October 26, 2020. https://doi.org/10.1073/pnas.2014349117

• Ecology

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    Insect pectinate antennae maximize odor capture efficiency at intermediate flight speeds

    Mourad Jaffar-Bandjee, Thomas Steinmann, Gijs Krijnen, and Jérôme Casas

    PNAS November 10, 2020 117 (45) 28126-28133; first published October 29, 2020. https://doi.org/10.1073/pnas.2007871117
  • Open Access

    A global network of marine protected areas for food

    • From the Cover

    Reniel B. Cabral, Darcy Bradley, Juan Mayorga, Whitney Goodell, Alan M. Friedlander, Enric Sala, Christopher Costello, and Steven D. Gaines

    PNAS November 10, 2020 117 (45) 28134-28139; first published October 26, 2020. https://doi.org/10.1073/pnas.2000174117
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    Land-use intensity alters networks between biodiversity, ecosystem functions, and services

    María R. Felipe-Lucia, Santiago Soliveres, Caterina Penone, Markus Fischer, Christian Ammer, Steffen Boch, Runa S. Boeddinghaus, Michael Bonkowski, François Buscot, Anna Maria Fiore-Donno, Kevin Frank, Kezia Goldmann, Martin M. Gossner, Norbert Hölzel, Malte Jochum, Ellen Kandeler, Valentin H. Klaus, Till Kleinebecker, Sophia Leimer, Peter Manning, Yvonne Oelmann, Hugo Saiz, Peter Schall, Michael Schloter, Ingo Schöning, Marion Schrumpf, Emily F. Solly, Barbara Stempfhuber, Wolfgang W. Weisser, Wolfgang Wilcke, Tesfaye Wubet, and Eric Allan

    PNAS November 10, 2020 117 (45) 28140-28149; first published October 22, 2020. https://doi.org/10.1073/pnas.2016210117
  • Open Access

    Ancient genomes reveal tropical bovid species in the Tibetan Plateau contributed to the prevalence of hunting game until the late Neolithic

    Ningbo Chen, Lele Ren, Linyao Du, Jiawen Hou, Victoria E. Mullin, Duo Wu, Xueye Zhao, Chunmei Li, Jiahui Huang, Xuebin Qi, Marco Rosario Capodiferro, Alessandro Achilli, Chuzhao Lei, Fahu Chen, Bing Su, Guanghui Dong, and Xiaoming Zhang

    PNAS November 10, 2020 117 (45) 28150-28159; first published October 19, 2020. https://doi.org/10.1073/pnas.2011696117
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    Climate drives the geography of marine consumption by changing predator communities

    Matthew A. Whalen, Ross D. B. Whippo, John J. Stachowicz, Paul H. York, Erin Aiello, Teresa Alcoverro, Andrew H. Altieri, Lisandro Benedetti-Cecchi, Camilla Bertolini, Midoli Bresch, Fabio Bulleri, Paul E. Carnell, Stéphanie Cimon, Rod M. Connolly, Mathieu Cusson, Meredith S. Diskin, Elrika D’Souza, Augusto A. V. Flores, F. Joel Fodrie, Aaron W. E. Galloway, Leo C. Gaskins, Olivia J. Graham, Torrance C. Hanley, Christopher J. Henderson, Clara M. Hereu, Margot Hessing-Lewis, Kevin A. Hovel, Brent B. Hughes, A. Randall Hughes, Kristin M. Hultgren, Holger Jänes, Dean S. Janiak, Lane N. Johnston, Pablo Jorgensen, Brendan P. Kelaher, Claudia Kruschel, Brendan S. Lanham, Kun-Seop Lee, Jonathan S. Lefcheck, Enrique Lozano-Álvarez, Peter I. Macreadie, Zachary L. Monteith, Nessa E. O’Connor, Andrew D. Olds, Jennifer K. O’Leary, Christopher J. Patrick, Oscar Pino, Alistair G. B. Poore, Michael A. Rasheed, Wendel W. Raymond, Katrin Reiss, O. Kennedy Rhoades, Max T. Robinson, Paige G. Ross, Francesca Rossi, Thomas A. Schlacher, Janina Seemann, Brian R. Silliman, Delbert L. Smee, Martin Thiel, Richard K. F. Unsworth, Brigitta I. van Tussenbroek, Adriana Vergés, Mallarie E. Yeager, Bree K. Yednock, Shelby L. Ziegler, and J. Emmett Duffy

    PNAS November 10, 2020 117 (45) 28160-28166; first published October 26, 2020. https://doi.org/10.1073/pnas.2005255117
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    Modular genetic control of social status in a cichlid fish

    Beau A. Alward, Vibhav A. Laud, Christopher J. Skalnik, Ryan A. York, Scott A. Juntti, and Russell D. Fernald

    PNAS November 10, 2020 117 (45) 28167-28174; first published October 26, 2020. https://doi.org/10.1073/pnas.2008925117

• Environmental Sciences

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    Outsized nutrient contributions from small tributaries to a Great Lake

    Robert J. Mooney, Emily H. Stanley, William C. Rosenthal, Peter C. Esselman, Anthony D. Kendall, and Peter B. McIntyre

    PNAS November 10, 2020 117 (45) 28175-28182; first published October 26, 2020. https://doi.org/10.1073/pnas.2001376117
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    Floristic evidence for alternative biome states in tropical Africa

    J. C. Aleman, A. Fayolle, C. Favier, A. C. Staver, K. G. Dexter, C. M. Ryan, A. F. Azihou, D. Bauman, M. te Beest, E. N. Chidumayo, J. A. Comiskey, J. P. G. M. Cromsigt, H. Dessard, J.-L. Doucet, M. Finckh, J.-F. Gillet, S. Gourlet-Fleury, G. P. Hempson, R. M. Holdo, B. Kirunda, F. N. Kouame, G. Mahy, F. Maiato P. Gonçalves, I. McNicol, P. Nieto Quintano, A. J. Plumptre, R. C. Pritchard, R. Revermann, C. B. Schmitt, A. M. Swemmer, H. Talila, E. Woollen, and M. D. Swaine

    PNAS November 10, 2020 117 (45) 28183-28190; first published October 27, 2020. https://doi.org/10.1073/pnas.2011515117

• Genetics

  • Open Access

    Genome-wide mapping of spontaneous genetic alterations in diploid yeast cells

    Yang Sui, Lei Qi, Jian-Kun Wu, Xue-Ping Wen, Xing-Xing Tang, Zhong-Jun Ma, Xue-Chang Wu, Ke Zhang, Robert J. Kokoska, Dao-Qiong Zheng, and Thomas D. Petes

    PNAS November 10, 2020 117 (45) 28191-28200; first published October 26, 2020. https://doi.org/10.1073/pnas.2018633117

    See companion article:

    • Hundreds of thousands of cell generations reveal a treasure chest of genome alterations

      - Nov 16, 2020
  • Open Access

    Comprehensive characterization of amino acid positions in protein structures reveals molecular effect of missense variants

    Sumaiya Iqbal, Eduardo Pérez-Palma, Jakob B. Jespersen, Patrick May, David Hoksza, Henrike O. Heyne, Shehab S. Ahmed, Zaara T. Rifat, M. Sohel Rahman, Kasper Lage, Aarno Palotie, Jeffrey R. Cottrell, Florence F. Wagner, Mark J. Daly, Arthur J. Campbell, and Dennis Lal

    PNAS November 10, 2020 117 (45) 28201-28211; first published October 26, 2020. https://doi.org/10.1073/pnas.2002660117
  • Open Access

    A mosaic analysis system with Cre or Tomato expression in the mouse

    Qun Wang, Yen-Yu Lin, Baojun Zhang, Jianxuan Wu, Sumedha Roy, Jeremy J. Ratiu, Yanping Xu, Meifang Dai, Laura P. Hale, Yue Xiong, Qi-Jing Li, and Yuan Zhuang

    PNAS November 10, 2020 117 (45) 28212-28220; first published October 26, 2020. https://doi.org/10.1073/pnas.2014308117

    See companion article:

    • A MASCOT for mosaic analysis

      - Nov 16, 2020
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    Characterization of systemic genomic instability in budding yeast

    Nadia M. V. Sampaio, V. P. Ajith, Ruth A. Watson, Lydia R. Heasley, Parijat Chakraborty, Aline Rodrigues-Prause, Ewa P. Malc, Piotr A. Mieczkowski, Koodali T. Nishant, and Juan Lucas Argueso

    PNAS November 10, 2020 117 (45) 28221-28231; first published October 26, 2020. https://doi.org/10.1073/pnas.2010303117

• Immunology and Inflammation

  • Open Access

    Nearly free surface silanols are the critical molecular moieties that initiate the toxicity of silica particles

    Cristina Pavan, Rosangela Santalucia, Riccardo Leinardi, Marco Fabbiani, Yousof Yakoub, Francine Uwambayinema, Piero Ugliengo, Maura Tomatis, Gianmario Martra, Francesco Turci, Dominique Lison, and Bice Fubini

    PNAS November 10, 2020 117 (45) 27836-27846; first published October 23, 2020. https://doi.org/10.1073/pnas.2008006117

    See companion article:

    • Are nearly free silanols a unifying structural determinant of silica particle toxicity?

      - Nov 13, 2020
  • Open Access

    HLA tapasin independence: broader peptide repertoire and HIV control

    Arman A. Bashirova, Mathias Viard, Vivek Naranbhai, Alba Grifoni, Wilfredo Garcia-Beltran, Marjan Akdag, Yuko Yuki, Xiaojiang Gao, Colm O’hUigin, Malini Raghavan, Steven Wolinsky, Jay H. Bream, Priya Duggal, Jeremy Martinson, Nelson L. Michael, Gregory D. Kirk, Susan P. Buchbinder, David Haas, James J. Goedert, Steven G. Deeks, Jacques Fellay, Bruce Walker, Philip Goulder, Peter Cresswell, Tim Elliott, Alessandro Sette, Jonathan Carlson, and Mary Carrington

    PNAS November 10, 2020 117 (45) 28232-28238; first published October 23, 2020. https://doi.org/10.1073/pnas.2013554117

    See companion article:

    • HLA polymorphism and tapasin independence influence outcomes of HIV and dengue virus infection

      - Nov 25, 2020
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    KLHL22 maintains PD-1 homeostasis and prevents excessive T cell suppression

    Xiao Albert Zhou, Jiadong Zhou, Long Zhao, Guihui Yu, Jun Zhan, Chanyi Shi, Ruoshi Yuan, Yan Wang, Changfeng Chen, Wenjia Zhang, Donghao Xu, Yingjiang Ye, Weibin Wang, Zhanlong Shen, Wei Wang, and Jiadong Wang

    PNAS November 10, 2020 117 (45) 28239-28250; first published October 27, 2020. https://doi.org/10.1073/pnas.2004570117
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    Phosphatidylinositol-4-kinase IIα licenses phagosomes for TLR4 signaling and MHC-II presentation in dendritic cells

    Cynthia López-Haber, Roni Levin-Konigsberg, Yueyao Zhu, Jing Bi-Karchin, Tamas Balla, Sergio Grinstein, Michael S. Marks, and Adriana R. Mantegazza

    PNAS November 10, 2020 117 (45) 28251-28262; first published October 27, 2020. https://doi.org/10.1073/pnas.2001948117
  • Open Access

    Stimulation of soluble guanylate cyclase exerts antiinflammatory actions in the liver through a VASP/NF-κB/NLRP3 inflammasome circuit

    Roger Flores-Costa, Marta Duran-Güell, Mireia Casulleras, Cristina López-Vicario, José Alcaraz-Quiles, Alba Diaz, Juan J. Lozano, Esther Titos, Katherine Hall, Renee Sarno, Jaime L. Masferrer, and Joan Clària

    PNAS November 10, 2020 117 (45) 28263-28274; first published October 26, 2020. https://doi.org/10.1073/pnas.2000466117

• Medical Sciences

  • Open Access

    Abnormal morphology biases hematocrit distribution in tumor vasculature and contributes to heterogeneity in tissue oxygenation

    Miguel O. Bernabeu, Jakub Köry, James A. Grogan, Bostjan Markelc, Albert Beardo, Mayeul d’Avezac, Romain Enjalbert, Jakob Kaeppler, Nicholas Daly, James Hetherington, Timm Krüger, Philip K. Maini, Joe M. Pitt-Francis, Ruth J. Muschel, Tomás Alarcón, and Helen M. Byrne

    PNAS November 10, 2020 117 (45) 27811-27819; first published October 27, 2020. https://doi.org/10.1073/pnas.2007770117
  • Open Access

    GPR56/ADGRG1 is a platelet collagen-responsive GPCR and hemostatic sensor of shear force

    Jennifer Yeung, Reheman Adili, Emily N. Stringham, Rong Luo, Alexander Vizurraga, Luciana K. Rosselli-Murai, Hannah M. Stoveken, Maiya Yu, Xianhua Piao, Michael Holinstat, and Gregory G. Tall

    PNAS November 10, 2020 117 (45) 28275-28286; first published October 23, 2020. https://doi.org/10.1073/pnas.2008921117
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    FOXM1 drives HPV+ HNSCC sensitivity to WEE1 inhibition

    Ahmed Diab, Hakan Gem, Jherek Swanger, Hee Yeon Kim, Kaleb Smith, Grace Zou, Sharat Raju, Michael Kao, Matthew Fitzgibbon, Keith R. Loeb, Cristina P. Rodriguez, Eduardo Méndez, Denise A. Galloway, Julia M. Sidorova, and Bruce E. Clurman

    PNAS November 10, 2020 117 (45) 28287-28296; first published October 22, 2020. https://doi.org/10.1073/pnas.2013921117
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    An allosteric peptide inhibitor of HIF-1α regulates hypoxia-induced retinal neovascularization

    Ayumi Usui-Ouchi, Edith Aguilar, Salome Murinello, Mitchell Prins, Marin L. Gantner, Peter E. Wright, Rebecca B. Berlow, and Martin Friedlander

    PNAS November 10, 2020 117 (45) 28297-28306; first published October 26, 2020. https://doi.org/10.1073/pnas.2017234117
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    The adaptor protein APPL2 controls glucose-stimulated insulin secretion via F-actin remodeling in pancreatic β-cells

    Baile Wang, Huige Lin, Xiaomu Li, Wenqi Lu, Jae Bum Kim, Aimin Xu, and Kenneth K. Y. Cheng

    PNAS November 10, 2020 117 (45) 28307-28315; first published October 29, 2020. https://doi.org/10.1073/pnas.2016997117
  • Open Access

    Harnessing ⁶⁴Cu/⁶⁷Cu for a theranostic approach to pretargeted radioimmunotherapy

    Outi Keinänen, Kimberly Fung, James M. Brennan, Nicholas Zia, Matt Harris, Ellen van Dam, Colin Biggin, Amos Hedt, Jon Stoner, Paul S. Donnelly, Jason S. Lewis, and Brian M. Zeglis

    PNAS November 10, 2020 117 (45) 28316-28327; first published October 26, 2020. https://doi.org/10.1073/pnas.2009960117

• Microbiology

  • Open Access

    A genomic and historical synthesis of plague in 18th century Eurasia

    Meriam Guellil, Oliver Kersten, Amine Namouchi, Stefania Luciani, Isolina Marota, Caroline A. Arcini, Elisabeth Iregren, Robert A. Lindemann, Gunnar Warfvinge, Lela Bakanidze, Lia Bitadze, Mauro Rubini, Paola Zaio, Monica Zaio, Damiano Neri, N. C. Stenseth, and Barbara Bramanti

    PNAS November 10, 2020 117 (45) 28328-28335; first published October 26, 2020. https://doi.org/10.1073/pnas.2009677117
  • Open Access

    Transcriptional and proteomic insights into the host response in fatal COVID-19 cases

    • From the Cover

    Meng Wu, Yaobing Chen, Han Xia, Changli Wang, Chin Yee Tan, Xunhui Cai, Yufeng Liu, Fenghu Ji, Peng Xiong, Ran Liu, Yuanlin Guan, Yaqi Duan, Dong Kuang, Sanpeng Xu, Hanghang Cai, Qin Xia, Dehua Yang, Ming-Wei Wang, Isaac M. Chiu, Chao Cheng, Philip P. Ahern, Liang Liu, Guoping Wang, Neeraj K. Surana, Tian Xia, and Dennis L. Kasper

    PNAS November 10, 2020 117 (45) 28336-28343; first published October 20, 2020. https://doi.org/10.1073/pnas.2018030117

    See companion article:

    • In fatal COVID-19, the immune response can control the virus but kill the patient

      - Nov 11, 2020
  • Open Access

    SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling

    Lisa Miorin, Thomas Kehrer, Maria Teresa Sanchez-Aparicio, Ke Zhang, Phillip Cohen, Roosheel S. Patel, Anastasija Cupic, Tadashi Makio, Menghan Mei, Elena Moreno, Oded Danziger, Kris M. White, Raveen Rathnasinghe, Melissa Uccellini, Shengyan Gao, Teresa Aydillo, Ignacio Mena, Xin Yin, Laura Martin-Sancho, Nevan J. Krogan, Sumit K. Chanda, Michael Schotsaert, Richard W. Wozniak, Yi Ren, Brad R. Rosenberg, Beatriz M. A. Fontoura, and Adolfo García-Sastre

    PNAS November 10, 2020 117 (45) 28344-28354; first published October 23, 2020. https://doi.org/10.1073/pnas.2016650117
  • Open Access

    Insights into bacterial cell division from a structure of EnvC bound to the FtsX periplasmic domain

    Jonathan Cook, Tyler C. Baverstock, Martin B. L. McAndrew, Phillip J. Stansfeld, David I. Roper, and Allister Crow

    PNAS November 10, 2020 117 (45) 28355-28365; first published October 23, 2020. https://doi.org/10.1073/pnas.2017134117
  • Open Access

    The polar Ras-like GTPase MglA activates type IV pilus via SgmX to enable twitching motility in Myxococcus xanthus

    Romain Mercier, Sarah Bautista, Maëlle Delannoy, Margaux Gibert, Annick Guiseppi, Julien Herrou, Emilia M. F. Mauriello, and Tâm Mignot

    PNAS November 10, 2020 117 (45) 28366-28373; first published October 22, 2020. https://doi.org/10.1073/pnas.2002783117
  • Open Access

    The shrimp nephrocomplex serves as a major portal of pathogen entry and is involved in the molting process

    Gaëtan M. A. De Gryse, Thuong Van Khuong, Benedicte Descamps, Wim Van Den Broeck, Christian Vanhove, Pieter Cornillie, Patrick Sorgeloos, Peter Bossier, and Hans J. Nauwynck

    PNAS November 10, 2020 117 (45) 28374-28383; first published October 23, 2020. https://doi.org/10.1073/pnas.2013518117
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    A CRISPR-Cas9 screen identifies mitochondrial translation as an essential process in latent KSHV infection of human endothelial cells

    Daniel L. Holmes, Daniel T. Vogt, and Michael Lagunoff

    PNAS November 10, 2020 117 (45) 28384-28392; first published October 29, 2020. https://doi.org/10.1073/pnas.2011645117

• Neuroscience

  • Open Access

    High-amplitude cofluctuations in cortical activity drive functional connectivity

    Farnaz Zamani Esfahlani, Youngheun Jo, Joshua Faskowitz, Lisa Byrge, Daniel P. Kennedy, Olaf Sporns, and Richard F. Betzel

    PNAS November 10, 2020 117 (45) 28393-28401; first published October 22, 2020. https://doi.org/10.1073/pnas.2005531117
  • Open Access

    Wake-sleep cycles are severely disrupted by diseases affecting cytoplasmic homeostasis

    Stephen Beesley, Dae Wook Kim, Matthew D’Alessandro, Yuanhu Jin, Kwangjun Lee, Hyunjeong Joo, Yang Young, Robert J. Tomko Jr, John Faulkner, Joshua Gamsby, Jae Kyoung Kim, and Choogon Lee

    PNAS November 10, 2020 117 (45) 28402-28411; first published October 26, 2020. https://doi.org/10.1073/pnas.2003524117
  • Open Access

    A spiking neural program for sensorimotor control during foraging in flying insects

    Hannes Rapp and Martin Paul Nawrot

    PNAS November 10, 2020 117 (45) 28412-28421; first published October 29, 2020. https://doi.org/10.1073/pnas.2009821117
  • Open Access

    Evolution of regulatory signatures in primate cortical neurons at cell-type resolution

    Alexey Kozlenkov, Marit W. Vermunt, Pasha Apontes, Junhao Li, Ke Hao, Chet C. Sherwood, Patrick R. Hof, John J. Ely, Michael Wegner, Eran A. Mukamel, Menno P. Creyghton, Eugene V. Koonin, and Stella Dracheva

    PNAS November 10, 2020 117 (45) 28422-28432; first published October 27, 2020. https://doi.org/10.1073/pnas.2011884117
  • Open Access

    Evidence for an effector-independent action system from people born without hands

    • From the Cover

    Yuqi Liu, Gilles Vannuscorps, Alfonso Caramazza, and Ella Striem-Amit

    PNAS November 10, 2020 117 (45) 28433-28441; first published October 26, 2020. https://doi.org/10.1073/pnas.2017789117

    See companion article:

    • Transforming abstract plans into concrete actions

      - Nov 11, 2020
  • Open Access

    Simple transformations capture auditory input to cortex

    Monzilur Rahman, Ben D. B. Willmore, Andrew J. King, and Nicol S. Harper

    PNAS November 10, 2020 117 (45) 28442-28451; first published October 23, 2020. https://doi.org/10.1073/pnas.1922033117
  • Open Access

    Differential functional connectivity underlying asymmetric reward-related activity in human and nonhuman primates

    Alizée Lopez-Persem, Léa Roumazeilles, Davide Folloni, Kévin Marche, Elsa F. Fouragnan, Nima Khalighinejad, Matthew F. S. Rushworth, and Jérôme Sallet

    PNAS November 10, 2020 117 (45) 28452-28462; first published October 29, 2020. https://doi.org/10.1073/pnas.2000759117
  • Open Access

    Time cells in the human hippocampus and entorhinal cortex support episodic memory

    Gray Umbach, Pranish Kantak, Joshua Jacobs, Michael Kahana, Brad E. Pfeiffer, Michael Sperling, and Bradley Lega

    PNAS November 10, 2020 117 (45) 28463-28474; first published October 27, 2020. https://doi.org/10.1073/pnas.2013250117
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    Echolocating bats detect but misperceive a multidimensional incongruent acoustic stimulus

    Sasha Danilovich, Gal Shalev, Arjan Boonman, Aya Goldshtein, and Yossi Yovel

    PNAS November 10, 2020 117 (45) 28475-28484; first published October 26, 2020. https://doi.org/10.1073/pnas.2005009117

• Physiology

  • Open Access

    The odorant receptor OR2W3 on airway smooth muscle evokes bronchodilation via a cooperative chemosensory tradeoff between TMEM16A and CFTR

    Jessie Huang, Hong Lam, Cynthia Koziol-White, Nathachit Limjunyawong, Donghwa Kim, Nicholas Kim, Nikhil Karmacharya, Premraj Rajkumar, Danielle Firer, Nicholas M. Dalesio, Joseph Jude, Richard C. Kurten, Jennifer L. Pluznick, Deepak A. Deshpande, Raymond B. Penn, Stephen B. Liggett, Reynold A. Panettieri Jr, Xinzhong Dong, and Steven S. An

    PNAS November 10, 2020 117 (45) 28485-28495; first published October 23, 2020. https://doi.org/10.1073/pnas.2003111117

• Plant Biology

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    Improving the taxonomy of fossil pollen using convolutional neural networks and superresolution microscopy

    • From the Cover

    Ingrid C. Romero, Shu Kong, Charless C. Fowlkes, Carlos Jaramillo, Michael A. Urban, Francisca Oboh-Ikuenobe, Carlos D’Apolito, and Surangi W. Punyasena

    PNAS November 10, 2020 117 (45) 28496-28505; first published October 23, 2020. https://doi.org/10.1073/pnas.2007324117

    See companion article:

    • Deep learning in deep time

      - Nov 09, 2020

• Population Biology

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    Fine-scale spatial clustering of measles nonvaccination that increases outbreak potential is obscured by aggregated reporting data

    Nina B. Masters, Marisa C. Eisenberg, Paul L. Delamater, Matthew Kay, Matthew L. Boulton, and Jon Zelner

    PNAS November 10, 2020 117 (45) 28506-28514; first published October 26, 2020. https://doi.org/10.1073/pnas.2011529117

• Sustainability Science

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    Land-use intensity alters networks between biodiversity, ecosystem functions, and services

    María R. Felipe-Lucia, Santiago Soliveres, Caterina Penone, Markus Fischer, Christian Ammer, Steffen Boch, Runa S. Boeddinghaus, Michael Bonkowski, François Buscot, Anna Maria Fiore-Donno, Kevin Frank, Kezia Goldmann, Martin M. Gossner, Norbert Hölzel, Malte Jochum, Ellen Kandeler, Valentin H. Klaus, Till Kleinebecker, Sophia Leimer, Peter Manning, Yvonne Oelmann, Hugo Saiz, Peter Schall, Michael Schloter, Ingo Schöning, Marion Schrumpf, Emily F. Solly, Barbara Stempfhuber, Wolfgang W. Weisser, Wolfgang Wilcke, Tesfaye Wubet, and Eric Allan

    PNAS November 10, 2020 117 (45) 28140-28149; first published October 22, 2020. https://doi.org/10.1073/pnas.2016210117
  • Open Access

    Improving rural health care reduces illegal logging and conserves carbon in a tropical forest

    Isabel J. Jones, Andrew J. MacDonald, Skylar R. Hopkins, Andrea J. Lund, Zac Yung-Chun Liu, Nurul Ihsan Fawzi, Mahardika Putra Purba, Katie Fankhauser, Andrew J. Chamberlin, Monica Nirmala, Arthur G. Blundell, Ashley Emerson, Jonathan Jennings, Lynne Gaffikin, Michele Barry, David Lopez-Carr, Kinari Webb, Giulio A. De Leo, and Susanne H. Sokolow

    PNAS November 10, 2020 117 (45) 28515-28524; first published October 26, 2020. https://doi.org/10.1073/pnas.2009240117