Proceedings of the National Academy of Sciences: 117 (47)

New Research In

November 24, 2020; vol. 117 no. 47

This Week in PNAS

This week's research highlights

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In This Issue
PNAS November 24, 2020 117 (47) 29243-29245; https://doi.org/10.1073/iti4720117

Opinion

Leading scientists discuss current issues

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Opinion: To stop the next pandemic, we need to unravel the origins of COVID-19
Front Matter
David A. Relman

PNAS November 24, 2020 117 (47) 29246-29248; first published November 3, 2020. https://doi.org/10.1073/pnas.2021133117

Inner Workings

An over-the-shoulder look at scientists at work

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Inner Workings: Physicists look to a new telescope to understand neutron stars and matter at the extremes
Front Matter
Stephen Ornes

PNAS November 24, 2020 117 (47) 29249-29252; first published November 4, 2020. https://doi.org/10.1073/pnas.2021447117

QnAs

Interviews with leading scientific researchers and newsmakers

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QnAs with Enquye Negash, Zeresenay Alemseged, and Jonathan Wynn
Tinsley H. Davis

PNAS November 24, 2020 117 (47) 29253-29256; first published November 16, 2020. https://doi.org/10.1073/pnas.2021561117
See companion article:
Dietary trends in herbivores from the Shungura Formation, southwestern Ethiopia
- Aug 24, 2020

Isotopic evidence for the timing of the dietary shift toward C₄ foods in eastern African Paranthropus
- Aug 24, 2020

Retrospective

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David Blackwell, 1919–2010: An explorer in mathematics and statistics
Peter J. Bickel

PNAS November 24, 2020 117 (47) 29257-29259; first published November 13, 2020. https://doi.org/10.1073/pnas.2020164117

Commentaries

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Pest pressure relates to similarity of crops and native plants
George G. Kennedy and Anders S. Huseth

PNAS November 24, 2020 117 (47) 29260-29262; first published November 9, 2020. https://doi.org/10.1073/pnas.2020945117
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Phylogenetic escape from pests reduces pesticides on some crop plants
- Oct 12, 2020
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On the way to understanding Yb₂Ti₂O₇
Sylvain Petit

PNAS November 24, 2020 117 (47) 29263-29264; first published November 9, 2020. https://doi.org/10.1073/pnas.2020105117
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Multiphase magnetism in Yb₂Ti₂O₇
- Oct 23, 2020
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Transforming abstract plans into concrete actions
Melvyn A. Goodale

PNAS November 24, 2020 117 (47) 29265-29267; first published November 11, 2020. https://doi.org/10.1073/pnas.2020708117
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Evidence for an effector-independent action system from people born without hands
- Oct 26, 2020
Open Access
Deep learning in deep time
Alexander E. White

PNAS November 24, 2020 117 (47) 29268-29270; first published November 9, 2020. https://doi.org/10.1073/pnas.2020870117
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Improving the taxonomy of fossil pollen using convolutional neural networks and superresolution microscopy
- Oct 23, 2020
Open Access
The first step in the success or failure of emerging pathogens
W. Ryan Easterday

PNAS November 24, 2020 117 (47) 29271-29273; first published November 13, 2020. https://doi.org/10.1073/pnas.2020709117
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Virulence mismatches in index hosts shape the outcomes of cross-species transmission
- Oct 29, 2020

Perspective

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Targeting the renin−angiotensin signaling pathway in COVID-19: Unanswered questions, opportunities, and challenges
Krishna Sriram, Rohit Loomba, and Paul A. Insel

PNAS November 24, 2020 117 (47) 29274-29282; first published November 17, 2020. https://doi.org/10.1073/pnas.2009875117

Letters

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rs1769793 variant reduces EGLN1 expression in skeletal muscle and hippocampus and contributes to high aerobic capacity in hypoxia
Guiyou Liu, Wenbo Zhao, Haihua Zhang, Tao Wang, Zhifa Han, and Xunming Ji

PNAS November 24, 2020 117 (47) 29283-29285; first published October 27, 2020. https://doi.org/10.1073/pnas.2010073117
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Reply to Liu et al.: The Andean EGLN1 adaptive allele could be a loss of function variant that increases HIF1-α in skeletal muscle
Tom D. Brutsaert, Melissa Kiyamu, Gianpietro Elias Revollendo, Jenna L. Isherwood, Frank S. Lee, Maria Rivera-Ch, Fabiola Leon-Velarde, Sudipta Ghosh, and Abigail W. Bigham

PNAS November 24, 2020 117 (47) 29286-29287; first published October 27, 2020. https://doi.org/10.1073/pnas.2012199117
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Association of EGLN1 gene with high aerobic capacity of Peruvian Quechua at high altitude
- Nov 11, 2019
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What is the correct stoichiometry of Kv2.1:Kv6.4 heteromers?
Aditya Pisupati, Keith J. Mickolajczyk, William O. Hancock, and Timothy Jegla

PNAS November 24, 2020 117 (47) 29288-29289; first published October 20, 2020. https://doi.org/10.1073/pnas.2017827117
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Reply to Pisupati et al.: Evaluating single subunit counting data to find the correct stoichiometry
Lena Möller, Glenn Regnier, Alain J. Labro, Dirk J. Snyders, and Rikard Blunck

PNAS November 24, 2020 117 (47) 29290-29291; first published October 20, 2020. https://doi.org/10.1073/pnas.2018077117
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Determining the correct stoichiometry of Kv2.1/Kv6.4 heterotetramers, functional in multiple stoichiometrical configurations
- Apr 13, 2020

Colloquium on Brain Produces Mind by Modeling

Introduction
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  The brain produces mind by modeling
  Richard M. Shiffrin, Danielle S. Bassett, Nikolaus Kriegeskorte, and Joshua B. Tenenbaum
  
  PNAS November 24, 2020 117 (47) 29299-29301; first published November 23, 2020. https://doi.org/10.1073/pnas.1912340117
Colloquium Papers
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  Rapid trial-and-error learning with simulation supports flexible tool use and physical reasoning
  Kelsey R. Allen, Kevin A. Smith, and Joshua B. Tenenbaum
  
  PNAS November 24, 2020 117 (47) 29302-29310; first published November 23, 2020. https://doi.org/10.1073/pnas.1912341117
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  Rational thoughts in neural codes
  Zhengwei Wu, Minhae Kwon, Saurabh Daptardar, Paul Schrater, and Xaq Pitkow
  
  PNAS November 24, 2020 117 (47) 29311-29320; first published November 23, 2020. https://doi.org/10.1073/pnas.1912336117
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  Low rank mechanisms underlying flexible visual representations
  Douglas A. Ruff, Cheng Xue, Lily E. Kramer, Faisal Baqai, and Marlene R. Cohen
  
  PNAS November 24, 2020 117 (47) 29321-29329; first published November 23, 2020. https://doi.org/10.1073/pnas.2005797117
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  Controversial stimuli: Pitting neural networks against each other as models of human cognition
  Tal Golan, Prashant C. Raju, and Nikolaus Kriegeskorte
  
  PNAS November 24, 2020 117 (47) 29330-29337; first published November 23, 2020. https://doi.org/10.1073/pnas.1912334117
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  Representations of common event structure in medial temporal lobe and frontoparietal cortex support efficient inference
  Neal W Morton, Margaret L. Schlichting, and Alison R. Preston
  
  PNAS November 24, 2020 117 (47) 29338-29345; first published November 23, 2020. https://doi.org/10.1073/pnas.1912338117
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  Aging and the encoding of changes in events: The role of neural activity pattern reinstatement
  David Stawarczyk, Christopher N. Wahlheim, Joset A. Etzel, Abraham Z. Snyder, and Jeffrey M. Zacks
  
  PNAS November 24, 2020 117 (47) 29346-29353; first published November 23, 2020. https://doi.org/10.1073/pnas.1918063117
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  Large-scale dissociations between views of objects, scenes, and reachable-scale environments in visual cortex
  Emilie L. Josephs and Talia Konkle
  
  PNAS November 24, 2020 117 (47) 29354-29362; first published November 23, 2020. https://doi.org/10.1073/pnas.1912333117
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  Local reliability weighting explains identification of partially masked objects in natural images
  Stephen Sebastian, Eric S. Seemiller, and Wilson S. Geisler
  
  PNAS November 24, 2020 117 (47) 29363-29370; first published November 23, 2020. https://doi.org/10.1073/pnas.1912331117
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  From likely to likable: The role of statistical typicality in human social assessment of faces
  Chaitanya K. Ryali, Stanny Goffin, Piotr Winkielman, and Angela J. Yu
  
  PNAS November 24, 2020 117 (47) 29371-29380; first published November 23, 2020. https://doi.org/10.1073/pnas.1912343117
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  Computational evidence for hierarchically structured reinforcement learning in humans
  Maria K. Eckstein and Anne G. E. Collins
  
  PNAS November 24, 2020 117 (47) 29381-29389; first published November 23, 2020. https://doi.org/10.1073/pnas.1912330117
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  AI, visual imagery, and a case study on the challenges posed by human intelligence tests
  Maithilee Kunda
  
  PNAS November 24, 2020 117 (47) 29390-29397; first published November 23, 2020. https://doi.org/10.1073/pnas.1912335117
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  Gaussian process linking functions for mind, brain, and behavior
  Giwon Bahg, Daniel G. Evans, Matthew Galdo, and Brandon M. Turner
  
  PNAS November 24, 2020 117 (47) 29398-29406; first published November 23, 2020. https://doi.org/10.1073/pnas.1912342117
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  How humans learn and represent networks
  Christopher W. Lynn and Danielle S. Bassett
  
  PNAS November 24, 2020 117 (47) 29407-29415; first published November 23, 2020. https://doi.org/10.1073/pnas.1912328117

Brief Reports

Open Access
Evidence that coronavirus superspreading is fat-tailed
Felix Wong and James J. Collins

PNAS November 24, 2020 117 (47) 29416-29418; first published November 2, 2020. https://doi.org/10.1073/pnas.2018490117
Open Access
COVID-19 pandemic impacts on global inland fisheries
Gretchen L. Stokes, Abigail J. Lynch, Benjamin S. Lowe, Simon Funge-Smith, John Valbo‐Jørgensen, and Samuel J. Smidt

PNAS November 24, 2020 117 (47) 29419-29421; first published November 2, 2020. https://doi.org/10.1073/pnas.2014016117

Physical Sciences

Applied Mathematics
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  How humans learn and represent networks
  Christopher W. Lynn and Danielle S. Bassett
  
  PNAS November 24, 2020 117 (47) 29407-29415; first published November 23, 2020. https://doi.org/10.1073/pnas.1912328117
Applied Physical Sciences
- Open Access
  Coupling of light and mechanics in a photonic crystal waveguide
  J.-B. Béguin, Z. Qin, X. Luan, and H. J. Kimble
  
  PNAS November 24, 2020 117 (47) 29422-29430; first published November 9, 2020. https://doi.org/10.1073/pnas.2014851117
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  Scaling confirmation of the thermodynamic dislocation theory
  J. S. Langer and K. C. Le
  
  PNAS November 24, 2020 117 (47) 29431-29434; first published November 9, 2020. https://doi.org/10.1073/pnas.2018647117
Biophysics and Computational Biology
- Open Access
  Master curve of boosted diffusion for 10 catalytic enzymes
  Ah-Young Jee, Tsvi Tlusty, and Steve Granick
  
  PNAS November 24, 2020 117 (47) 29435-29441; first published November 9, 2020. https://doi.org/10.1073/pnas.2019810117
  
  See companion article:
  A thermodynamic perspective on enhanced enzyme diffusion
  - Dec 09, 2020
Chemistry
- Open Access
  Enhanced and stabilized hydrogen production from methanol by ultrasmall Ni nanoclusters immobilized on defect-rich h-BN nanosheets
  Zhuolei Zhang, Ji Su, Ana Sanz Matias, Madeleine Gordon, Yi-Sheng Liu, Jinghua Guo, Chengyu Song, Chaochao Dun, David Prendergast, Gabor A. Somorjai, and Jeffrey J. Urban
  
  PNAS November 24, 2020 117 (47) 29442-29452; first published November 9, 2020. https://doi.org/10.1073/pnas.2015897117
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  Underpotential lithium plating on graphite anodes caused by temperature heterogeneity
  Hansen Wang, Yangying Zhu, Sang Cheol Kim, Allen Pei, Yanbin Li, David T. Boyle, Hongxia Wang, Zewen Zhang, Yusheng Ye, William Huang, Yayuan Liu, Jinwei Xu, Jun Li, Fang Liu, and Yi Cui
  
  PNAS November 24, 2020 117 (47) 29453-29461; first published November 9, 2020. https://doi.org/10.1073/pnas.2009221117
- Open Access
  Regulating kinetics and thermodynamics of electrochemical nitrogen reduction with metal single-atom catalysts in a pressurized electrolyser
  Haiyuan Zou, Weifeng Rong, Shuting Wei, Yongfei Ji, and Lele Duan
  
  PNAS November 24, 2020 117 (47) 29462-29468; first published November 10, 2020. https://doi.org/10.1073/pnas.2015108117
- Open Access
  Structure of human endo-α-1,2-mannosidase (MANEA), an antiviral host-glycosylation target
  Łukasz F. Sobala, Pearl Z. Fernandes, Zalihe Hakki, Andrew J. Thompson, Jonathon D. Howe, Michelle Hill, Nicole Zitzmann, Scott Davies, Zania Stamataki, Terry D. Butters, Dominic S. Alonzi, Spencer J. Williams, and Gideon J. Davies
  
  PNAS November 24, 2020 117 (47) 29595-29601; first published November 5, 2020. https://doi.org/10.1073/pnas.2013620117
Computer Sciences
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  AI, visual imagery, and a case study on the challenges posed by human intelligence tests
  Maithilee Kunda
  
  PNAS November 24, 2020 117 (47) 29390-29397; first published November 23, 2020. https://doi.org/10.1073/pnas.1912335117
Earth, Atmospheric, and Planetary Sciences
- Open Access
  Mercury isotopes identify near-surface marine mercury in deep-sea trench biota
  From the Cover
  
  Inaugural Article
  
  Joel D. Blum, Jeffrey C. Drazen, Marcus W. Johnson, Brian N. Popp, Laura C. Motta, and Alan J. Jamieson
  
  PNAS November 24, 2020 117 (47) 29292-29298; first published November 16, 2020. https://doi.org/10.1073/pnas.2012773117
  
  See companion article:
  Profile of Joel D. Blum
  - Nov 23, 2020
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  Quantification of organic aerosol and brown carbon evolution in fresh wildfire plumes
  Brett B. Palm, Qiaoyun Peng, Carley D. Fredrickson, Ben H. Lee, Lauren A. Garofalo, Matson A. Pothier, Sonia M. Kreidenweis, Delphine K. Farmer, Rudra P. Pokhrel, Yingjie Shen, Shane M. Murphy, Wade Permar, Lu Hu, Teresa L. Campos, Samuel R. Hall, Kirk Ullmann, Xuan Zhang, Frank Flocke, Emily V. Fischer, and Joel A. Thornton
  
  PNAS November 24, 2020 117 (47) 29469-29477; first published November 4, 2020. https://doi.org/10.1073/pnas.2012218117
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  Rapid reductions and millennial-scale variability in Nordic Seas sea ice cover during abrupt glacial climate changes
  Henrik Sadatzki, Niccolò Maffezzoli, Trond M. Dokken, Margit H. Simon, Sarah M. P. Berben, Kirsten Fahl, Helle A. Kjær, Andrea Spolaor, Ruediger Stein, Paul Vallelonga, Bo M. Vinther, and Eystein Jansen
  
  PNAS November 24, 2020 117 (47) 29478-29486; first published November 9, 2020. https://doi.org/10.1073/pnas.2005849117
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  Paleocene latitude of the Kohistan–Ladakh arc indicates multistage India–Eurasia collision
  Craig R. Martin, Oliver Jagoutz, Rajeev Upadhyay, Leigh H. Royden, Michael P. Eddy, Elizabeth Bailey, Claire I. O. Nichols, and Benjamin P. Weiss
  
  PNAS November 24, 2020 117 (47) 29487-29494; first published November 4, 2020. https://doi.org/10.1073/pnas.2009039117
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  Increasing risk of another Cape Town “Day Zero” drought in the 21st century
  Salvatore Pascale, Sarah B. Kapnick, Thomas L. Delworth, and William F. Cooke
  
  PNAS November 24, 2020 117 (47) 29495-29503; first published November 9, 2020. https://doi.org/10.1073/pnas.2009144117
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  The origin of secondary microseism Love waves
  Lucia Gualtieri, Etienne Bachmann, Frederik J. Simons, and Jeroen Tromp
  
  PNAS November 24, 2020 117 (47) 29504-29511; first published November 9, 2020. https://doi.org/10.1073/pnas.2013806117
Engineering
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  Dual self-regulated delivery of insulin and glucagon by a hybrid patch
  Zejun Wang, Jinqiang Wang, Hongjun Li, Jicheng Yu, Guojun Chen, Anna R. Kahkoska, Valerie Wu, Yi Zeng, Di Wen, Jayson R. Miedema, John B. Buse, and Zhen Gu
  
  PNAS November 24, 2020 117 (47) 29512-29517; first published November 11, 2020. https://doi.org/10.1073/pnas.2011099117
- Open Access
  Electric field-driven microfluidics for rapid CRISPR-based diagnostics and its application to detection of SARS-CoV-2
  Ashwin Ramachandran, Diego A. Huyke, Eesha Sharma, Malaya K. Sahoo, ChunHong Huang, Niaz Banaei, Benjamin A. Pinsky, and Juan G. Santiago
  
  PNAS November 24, 2020 117 (47) 29518-29525; first published November 4, 2020. https://doi.org/10.1073/pnas.2010254117
Environmental Sciences
- Open Access
  Potential for sustainable irrigation expansion in a 3 °C warmer climate
  Lorenzo Rosa, Davide Danilo Chiarelli, Matteo Sangiorgio, Areidy Aracely Beltran-Peña, Maria Cristina Rulli, Paolo D’Odorico, and Inez Fung
  
  PNAS November 24, 2020 117 (47) 29526-29534; first published November 9, 2020. https://doi.org/10.1073/pnas.2017796117
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  The quest for improved air quality may push China to continue its CO₂ reduction beyond the Paris Commitment
  Jia Xing, Xi Lu, Shuxiao Wang, Tong Wang, Dian Ding, Sha Yu, Drew Shindell, Yang Ou, Lidia Morawska, Siwei Li, Lu Ren, Yuqiang Zhang, Dan Loughlin, Haotian Zheng, Bin Zhao, Shuchang Liu, Kirk R. Smith, and Jiming Hao
  
  PNAS November 24, 2020 117 (47) 29535-29542; first published November 9, 2020. https://doi.org/10.1073/pnas.2013297117
Physics
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  Superconductivity, correlated insulators, and Wess–Zumino–Witten terms in twisted bilayer graphene
  Maine Christos, Subir Sachdev, and Mathias S. Scheurer
  
  PNAS November 24, 2020 117 (47) 29543-29554; first published November 9, 2020. https://doi.org/10.1073/pnas.2014691117
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  Quantum spin-liquid states in an organic magnetic layer and molecular rotor hybrid
  Péter Szirmai, Cécile Mézière, Guillaume Bastien, Pawel Wzietek, Patrick Batail, Edoardo Martino, Konstantins Mantulnikovs, Andrea Pisoni, Kira Riedl, Stephen Cottrell, Christopher Baines, László Forró, and Bálint Náfrádi
  
  PNAS November 24, 2020 117 (47) 29555-29560; first published November 5, 2020. https://doi.org/10.1073/pnas.2000188117
- Open Access
  Observation of non-Hermitian topology and its bulk–edge correspondence in an active mechanical metamaterial
  Ananya Ghatak, Martin Brandenbourger, Jasper van Wezel, and Corentin Coulais
  
  PNAS November 24, 2020 117 (47) 29561-29568; first published November 9, 2020. https://doi.org/10.1073/pnas.2010580117
Sustainability Science
- Open Access
  Marine wild-capture fisheries after nuclear war
  Kim J. N. Scherrer, Cheryl S. Harrison, Ryan F. Heneghan, Eric Galbraith, Charles G. Bardeen, Joshua Coupe, Jonas Jägermeyr, Nicole S. Lovenduski, August Luna, Alan Robock, Jessica Stevens, Samantha Stevenson, Owen B. Toon, and Lili Xia
  
  PNAS November 24, 2020 117 (47) 29748-29758; first published November 9, 2020. https://doi.org/10.1073/pnas.2008256117

Biological Sciences

Agricultural Sciences
- Open Access
  Potential for sustainable irrigation expansion in a 3 °C warmer climate
  Lorenzo Rosa, Davide Danilo Chiarelli, Matteo Sangiorgio, Areidy Aracely Beltran-Peña, Maria Cristina Rulli, Paolo D’Odorico, and Inez Fung
  
  PNAS November 24, 2020 117 (47) 29526-29534; first published November 9, 2020. https://doi.org/10.1073/pnas.2017796117
Applied Biological Sciences
- You have access
  Dual self-regulated delivery of insulin and glucagon by a hybrid patch
  Zejun Wang, Jinqiang Wang, Hongjun Li, Jicheng Yu, Guojun Chen, Anna R. Kahkoska, Valerie Wu, Yi Zeng, Di Wen, Jayson R. Miedema, John B. Buse, and Zhen Gu
  
  PNAS November 24, 2020 117 (47) 29512-29517; first published November 11, 2020. https://doi.org/10.1073/pnas.2011099117
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  A facile method of mapping HIV-1 neutralizing epitopes using chemically masked cysteines and deep sequencing
  Rohini Datta, Rohan Roy Chowdhury, Kavyashree Manjunath, Luke Elizabeth Hanna, and Raghavan Varadarajan
  
  PNAS November 24, 2020 117 (47) 29584-29594; first published November 9, 2020. https://doi.org/10.1073/pnas.2010256117
Biochemistry
- Open Access
  Structure of human endo-α-1,2-mannosidase (MANEA), an antiviral host-glycosylation target
  Łukasz F. Sobala, Pearl Z. Fernandes, Zalihe Hakki, Andrew J. Thompson, Jonathon D. Howe, Michelle Hill, Nicole Zitzmann, Scott Davies, Zania Stamataki, Terry D. Butters, Dominic S. Alonzi, Spencer J. Williams, and Gideon J. Davies
  
  PNAS November 24, 2020 117 (47) 29595-29601; first published November 5, 2020. https://doi.org/10.1073/pnas.2013620117
- Open Access
  Assembly of the peripheral stalk of ATP synthase in human mitochondria
  Jiuya He, Joe Carroll, Shujing Ding, Ian M. Fearnley, Martin G. Montgomery, and John E. Walker
  
  PNAS November 24, 2020 117 (47) 29602-29608; first published November 9, 2020. https://doi.org/10.1073/pnas.2017987117
- Open Access
  Reversing the direction of drug transport mediated by the human multidrug transporter P-glycoprotein
  Andaleeb Sajid, Sabrina Lusvarghi, Megumi Murakami, Eduardo E. Chufan, Biebele Abel, Michael M. Gottesman, Stewart R. Durell, and Suresh V. Ambudkar
  
  PNAS November 24, 2020 117 (47) 29609-29617; first published November 9, 2020. https://doi.org/10.1073/pnas.2016270117
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  Evolution of insulin at the edge of foldability and its medical implications
  Nischay K. Rege, Ming Liu, Yanwu Yang, Balamurugan Dhayalan, Nalinda P. Wickramasinghe, Yen-Shan Chen, Leili Rahimi, Huan Guo, Leena Haataja, Jinhong Sun, Faramarz Ismail-Beigi, Nelson B. Phillips, Peter Arvan, and Michael A. Weiss
  
  PNAS November 24, 2020 117 (47) 29618-29628; first published November 5, 2020. https://doi.org/10.1073/pnas.2010908117
- Open Access
  Water oxidation by photosystem II is the primary source of electrons for sustained H₂ photoproduction in nutrient-replete green algae
  Sergey Kosourov, Valéria Nagy, Dmitry Shevela, Martina Jokel, Johannes Messinger, and Yagut Allahverdiyeva
  
  PNAS November 24, 2020 117 (47) 29629-29636; first published November 9, 2020. https://doi.org/10.1073/pnas.2009210117
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  Structural and functional characterization of the pore-forming domain of pinholin S²¹68
  Lena M. E. Steger, Annika Kohlmeyer, Parvesh Wadhwani, Jochen Bürck, Erik Strandberg, Johannes Reichert, Stephan L. Grage, Sergii Afonin, Marin Kempfer, Anne C. Görner, Julia Koch, Torsten H. Walther, and Anne S. Ulrich
  
  PNAS November 24, 2020 117 (47) 29637-29646; first published November 5, 2020. https://doi.org/10.1073/pnas.2007979117
- Open Access
  The 3 × 120° rotary mechanism of Paracoccus denitrificans F₁-ATPase is different from that of the bacterial and mitochondrial F₁-ATPases
  Mariel Zarco-Zavala, Ryo Watanabe, Duncan G. G. McMillan, Toshiharu Suzuki, Hiroshi Ueno, Francisco Mendoza-Hoffmann, José J. García-Trejo, and Hiroyuki Noji
  
  PNAS November 24, 2020 117 (47) 29647-29657; first published November 9, 2020. https://doi.org/10.1073/pnas.2003163117
- Open Access
  A majority of Rhodobacter sphaeroides promoters lack a crucial RNA polymerase recognition feature, enabling coordinated transcription activation
  Kemardo K. Henry, Wilma Ross, Kevin S. Myers, Kimberly C. Lemmer, Jessica M. Vera, Robert Landick, Timothy J. Donohue, and Richard L. Gourse
  
  PNAS November 24, 2020 117 (47) 29658-29668; first published November 9, 2020. https://doi.org/10.1073/pnas.2010087117
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  Lipoteichoic acid polymer length is determined by competition between free starter units
  Anthony R. Hesser, Kaitlin Schaefer, Wonsik Lee, and Suzanne Walker
  
  PNAS November 24, 2020 117 (47) 29669-29676; first published November 10, 2020. https://doi.org/10.1073/pnas.2008929117
Biophysics and Computational Biology
- Open Access
  Master curve of boosted diffusion for 10 catalytic enzymes
  Ah-Young Jee, Tsvi Tlusty, and Steve Granick
  
  PNAS November 24, 2020 117 (47) 29435-29441; first published November 9, 2020. https://doi.org/10.1073/pnas.2019810117
  
  See companion article:
  A thermodynamic perspective on enhanced enzyme diffusion
  - Dec 09, 2020
- You have access
  Michler’s hydrol blue elucidates structural differences in prion strains
  Yiling Xiao, Sandra Rocha, Catherine C. Kitts, Anna Reymer, Tamás Beke-Somfai, Kendra K. Frederick, and Bengt Nordén
  
  PNAS November 24, 2020 117 (47) 29677-29683; first published November 9, 2020. https://doi.org/10.1073/pnas.2001732117
- Open Access
  Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells
  Matthias Barone, Matthias Müller, Slim Chiha, Jiang Ren, Dominik Albat, Arne Soicke, Stephan Dohmen, Marco Klein, Judith Bruns, Maarten van Dinther, Robert Opitz, Peter Lindemann, Monika Beerbaum, Kathrin Motzny, Yvette Roske, Peter Schmieder, Rudolf Volkmer, Marc Nazaré, Udo Heinemann, Hartmut Oschkinat, Peter ten Dijke, Hans-Günther Schmalz, and Ronald Kühne
  
  PNAS November 24, 2020 117 (47) 29684-29690; first published November 12, 2020. https://doi.org/10.1073/pnas.2007213117
Cell Biology
- You have access
  Degenerative and regenerative pathways underlying Duchenne muscular dystrophy revealed by single-nucleus RNA sequencing
  Francesco Chemello, Zhaoning Wang, Hui Li, John R. McAnally, Ning Liu, Rhonda Bassel-Duby, and Eric N. Olson
  
  PNAS November 24, 2020 117 (47) 29691-29701; first published November 4, 2020. https://doi.org/10.1073/pnas.2018391117
  
  See companion article:
  Decoding DMD transcriptional networks using single‐nucleus RNA sequencing
  - Dec 02, 2020
- Open Access
  Correlated cryogenic fluorescence microscopy and electron cryo-tomography shows that exogenous TRIM5α can form hexagonal lattices or autophagy aggregates in vivo
  Stephen D. Carter, João I. Mamede, Thomas J. Hope, and Grant J. Jensen
  
  PNAS November 24, 2020 117 (47) 29702-29711; first published November 5, 2020. https://doi.org/10.1073/pnas.1920323117
- Open Access
  Ammonium transporter expression in sperm of the disease vector Aedes aegypti mosquito influences male fertility
  Andrea C. Durant and Andrew Donini
  
  PNAS November 24, 2020 117 (47) 29712-29719; first published November 9, 2020. https://doi.org/10.1073/pnas.2011648117
Ecology
- Open Access
  Forest and woodland replacement patterns following drought-related mortality
  Enric Batllori, Francisco Lloret, Tuomas Aakala, William R. L. Anderegg, Ermias Aynekulu, Devin P. Bendixsen, Abdallah Bentouati, Christof Bigler, C. John Burk, J. Julio Camarero, Michele Colangelo, Jonathan D. Coop, Roderick Fensham, M. Lisa Floyd, Lucía Galiano, Joseph L. Ganey, Patrick Gonzalez, Anna L. Jacobsen, Jeffrey Michael Kane, Thomas Kitzberger, Juan C. Linares, Suzanne B. Marchetti, George Matusick, Michael Michaelian, Rafael M. Navarro-Cerrillo, Robert Brandon Pratt, Miranda D. Redmond, Andreas Rigling, Francesco Ripullone, Gabriel Sangüesa-Barreda, Yamila Sasal, Sandra Saura-Mas, Maria Laura Suarez, Thomas T. Veblen, Albert Vilà-Cabrera, Caroline Vincke, and Ben Zeeman
  
  PNAS November 24, 2020 117 (47) 29720-29729; first published November 2, 2020. https://doi.org/10.1073/pnas.2002314117
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  A climatic dipole drives short- and long-term patterns of postfire forest recovery in the western United States
  Caitlin E. Littlefield, Solomon Z. Dobrowski, John T. Abatzoglou, Sean A. Parks, and Kimberley T. Davis
  
  PNAS November 24, 2020 117 (47) 29730-29737; first published November 9, 2020. https://doi.org/10.1073/pnas.2007434117
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  Seasonal and diel patterns of abundance and activity of viruses in the Red Sea
  Gur Hevroni, José Flores-Uribe, Oded Béjà, and Alon Philosof
  
  PNAS November 24, 2020 117 (47) 29738-29747; first published November 10, 2020. https://doi.org/10.1073/pnas.2010783117
Environmental Sciences
- Open Access
  Marine wild-capture fisheries after nuclear war
  Kim J. N. Scherrer, Cheryl S. Harrison, Ryan F. Heneghan, Eric Galbraith, Charles G. Bardeen, Joshua Coupe, Jonas Jägermeyr, Nicole S. Lovenduski, August Luna, Alan Robock, Jessica Stevens, Samantha Stevenson, Owen B. Toon, and Lili Xia
  
  PNAS November 24, 2020 117 (47) 29748-29758; first published November 9, 2020. https://doi.org/10.1073/pnas.2008256117
Evolution
- Open Access
  Exploitative leaders incite intergroup warfare in a social mammal
  From the Cover
  
  Rufus A. Johnstone, Michael A. Cant, Dominic Cram, and Faye J. Thompson
  
  PNAS November 24, 2020 117 (47) 29759-29766; first published November 9, 2020. https://doi.org/10.1073/pnas.2003745117
  
  See companion article:
  Hawks, Doves, and mongooses
  - Nov 13, 2020
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  Selection on phenotypic plasticity favors thermal canalization
  Erik I. Svensson, Miguel Gomez-Llano, and John T. Waller
  
  PNAS November 24, 2020 117 (47) 29767-29774; first published November 9, 2020. https://doi.org/10.1073/pnas.2012454117
Genetics
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  The evolutionary origin and domestication history of goldfish (Carassius auratus)
  From the Cover
  
  Duo Chen, Qing Zhang, Weiqi Tang, Zhen Huang, Gang Wang, Yongjun Wang, Jiaxian Shi, Huimin Xu, Lianyu Lin, Zhen Li, Wenchao Chi, Likun Huang, Jing Xia, Xingtan Zhang, Lin Guo, Yuanyuan Wang, Panpan Ma, Juan Tang, Gang Zhou, Min Liu, Fuyan Liu, Xiuting Hua, Baiyu Wang, Qiaochu Shen, Qing Jiang, Jingxian Lin, Xuequn Chen, Hongbo Wang, Meijie Dou, Lei Liu, Haoran Pan, Yiying Qi, Bin Wu, Jingping Fang, Yitao Zhou, Wan Cen, Wenjin He, Qiujin Zhang, Ting Xue, Gang Lin, Wenchun Zhang, Zhongjian Liu, Liming Qu, Aiming Wang, Qichang Ye, Jianming Chen, Yanding Zhang, Ray Ming, Marc Van Montagu, Haibao Tang, Yves Van de Peer, Youqiang Chen, and Jisen Zhang
  
  PNAS November 24, 2020 117 (47) 29775-29785; first published November 2, 2020. https://doi.org/10.1073/pnas.2005545117
- Open Access
  Oncogenic allelic interaction in Xiphophorus highlights hybrid incompatibility
  Yuan Lu, Angel Sandoval, Sarah Voss, Zhao Lai, Susanne Kneitz, Will Boswell, Mikki Boswell, Markita Savage, Christi Walter, Wes Warren, Manfred Schartl, and Ronald Walter
  
  PNAS November 24, 2020 117 (47) 29786-29794; first published November 9, 2020. https://doi.org/10.1073/pnas.2010133117
  
  See companion article:
  A cancer in hybrids
  - Dec 30, 2020
Immunology and Inflammation
- Open Access
  Structure of a protective epitope reveals the importance of acetylation of Neisseria meningitidis serogroup A capsular polysaccharide
  Pedro Henriques, Lucia Dello Iacono, Ana Gimeno, Alessia Biolchi, Maria Rosaria Romano, Ana Arda, Gonҫalo J. L. Bernardes, Jesus Jimenez-Barbero, Francesco Berti, Rino Rappuoli, and Roberto Adamo
  
  PNAS November 24, 2020 117 (47) 29795-29802; first published November 6, 2020. https://doi.org/10.1073/pnas.2011385117
- Open Access
  Identification of a brainstem locus that inhibits tumor necrosis factor
  Adam M. Kressel, Tea Tsaava, Yaakov A. Levine, Eric H. Chang, Meghan E. Addorisio, Qing Chang, Barry J. Burbach, Daniela Carnevale, Giuseppe Lembo, Anthony M. Zador, Ulf Andersson, Valentin A. Pavlov, Sangeeta S. Chavan, and Kevin J. Tracey
  
  PNAS November 24, 2020 117 (47) 29803-29810; first published November 9, 2020. https://doi.org/10.1073/pnas.2008213117
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  Type 1 interferon-dependent repression of NLRC4 and iPLA2 licenses down-regulation of Salmonella flagellin inside macrophages
  Ajay Suresh Akhade, Shaikh M. Atif, Bhavana S. Lakshmi, Neha Dikshit, Kelly T. Hughes, Ayub Qadri, and Naeha Subramanian
  
  PNAS November 24, 2020 117 (47) 29811-29822; first published November 11, 2020. https://doi.org/10.1073/pnas.2002747117
Medical Sciences
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  Excess of the NF-ĸB p50 subunit generated by the ubiquitin ligase KPC1 suppresses tumors via PD-L1– and chemokines-mediated mechanisms
  Yelena Kravtsova-Ivantsiv, Gilad Goldhirsh, Alexandra Ivantsiv, Ofer Ben Itzhak, Yong Tae Kwon, Eli Pikarsky, and Aaron Ciechanover
  
  PNAS November 24, 2020 117 (47) 29823-29831; first published November 9, 2020. https://doi.org/10.1073/pnas.2019604117
Microbiology
- Open Access
  Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection
  Wei Li, Chuan Chen, Aleksandra Drelich, David R. Martinez, Lisa E. Gralinski, Zehua Sun, Alexandra Schäfer, Swarali S. Kulkarni, Xianglei Liu, Sarah R. Leist, Doncho V. Zhelev, Liyong Zhang, Ye-Jin Kim, Eric C. Peterson, Alex Conard, John W. Mellors, Chien-Te K. Tseng, Darryl Falzarano, Ralph S. Baric, and Dimiter S. Dimitrov
  
  PNAS November 24, 2020 117 (47) 29832-29838; first published November 2, 2020. https://doi.org/10.1073/pnas.2010197117
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  Discovery of small-molecule inhibitors of multidrug-resistance plasmid maintenance using a high-throughput screening approach
  Katelyn E. Zulauf and James E. Kirby
  
  PNAS November 24, 2020 117 (47) 29839-29850; first published November 9, 2020. https://doi.org/10.1073/pnas.2005948117
- Open Access
  Structure of the mature kinetoplastids mitoribosome and insights into its large subunit biogenesis
  Heddy Soufari, Florent Waltz, Camila Parrot, Stéphanie Durrieu-Gaillard, Anthony Bochler, Lauriane Kuhn, Marie Sissler, and Yaser Hashem
  
  PNAS November 24, 2020 117 (47) 29851-29861; first published November 9, 2020. https://doi.org/10.1073/pnas.2011301117
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  Type I interferon remodels lysosome function and modifies intestinal epithelial defense
  Hailong Zhang, Abdelrahim Zoued, Xu Liu, Brandon Sit, and Matthew K. Waldor
  
  PNAS November 24, 2020 117 (47) 29862-29871; first published November 10, 2020. https://doi.org/10.1073/pnas.2010723117
Neuroscience
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  Rational thoughts in neural codes
  Zhengwei Wu, Minhae Kwon, Saurabh Daptardar, Paul Schrater, and Xaq Pitkow
  
  PNAS November 24, 2020 117 (47) 29311-29320; first published November 23, 2020. https://doi.org/10.1073/pnas.1912336117
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  Low rank mechanisms underlying flexible visual representations
  Douglas A. Ruff, Cheng Xue, Lily E. Kramer, Faisal Baqai, and Marlene R. Cohen
  
  PNAS November 24, 2020 117 (47) 29321-29329; first published November 23, 2020. https://doi.org/10.1073/pnas.2005797117
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  Representations of common event structure in medial temporal lobe and frontoparietal cortex support efficient inference
  Neal W Morton, Margaret L. Schlichting, and Alison R. Preston
  
  PNAS November 24, 2020 117 (47) 29338-29345; first published November 23, 2020. https://doi.org/10.1073/pnas.1912338117
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  Aging and the encoding of changes in events: The role of neural activity pattern reinstatement
  David Stawarczyk, Christopher N. Wahlheim, Joset A. Etzel, Abraham Z. Snyder, and Jeffrey M. Zacks
  
  PNAS November 24, 2020 117 (47) 29346-29353; first published November 23, 2020. https://doi.org/10.1073/pnas.1918063117
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  From likely to likable: The role of statistical typicality in human social assessment of faces
  Chaitanya K. Ryali, Stanny Goffin, Piotr Winkielman, and Angela J. Yu
  
  PNAS November 24, 2020 117 (47) 29371-29380; first published November 23, 2020. https://doi.org/10.1073/pnas.1912343117
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  Computational evidence for hierarchically structured reinforcement learning in humans
  Maria K. Eckstein and Anne G. E. Collins
  
  PNAS November 24, 2020 117 (47) 29381-29389; first published November 23, 2020. https://doi.org/10.1073/pnas.1912330117
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  Gaussian process linking functions for mind, brain, and behavior
  Giwon Bahg, Daniel G. Evans, Matthew Galdo, and Brandon M. Turner
  
  PNAS November 24, 2020 117 (47) 29398-29406; first published November 23, 2020. https://doi.org/10.1073/pnas.1912342117
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  A modeling framework for adaptive lifelong learning with transfer and savings through gating in the prefrontal cortex
  Ben Tsuda, Kay M. Tye, Hava T. Siegelmann, and Terrence J. Sejnowski
  
  PNAS November 24, 2020 117 (47) 29872-29882; first published November 5, 2020. https://doi.org/10.1073/pnas.2009591117
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  Neuropsychological and neuropathological observations of a long-studied case of memory impairment
  Larry R. Squire, Soyun Kim, Jennifer C. Frascino, Jacopo Annese, Jeffrey Bennett, Ricardo Insausti, and David G. Amaral
  
  PNAS November 24, 2020 117 (47) 29883-29893; first published November 9, 2020. https://doi.org/10.1073/pnas.2018960117
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  Deafness mutation D572N of TMC1 destabilizes TMC1 expression by disrupting LHFPL5 binding
  Xiaojie Yu, Qirui Zhao, Xiaofen Li, Yixuan Chen, Ye Tian, Shuang Liu, Wei Xiong, and Pingbo Huang
  
  PNAS November 24, 2020 117 (47) 29894-29903; first published November 9, 2020. https://doi.org/10.1073/pnas.2011147117
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  Reshaping circadian metabolism in the suprachiasmatic nucleus and prefrontal cortex by nutritional challenge
  Paola Tognini, Muntaha Samad, Kenichiro Kinouchi, Yu Liu, Jean-Christophe Helbling, Marie-Pierre Moisan, Kristin L. Eckel-Mahan, Pierre Baldi, and Paolo Sassone-Corsi
  
  PNAS November 24, 2020 117 (47) 29904-29913; first published November 10, 2020. https://doi.org/10.1073/pnas.2016589117
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  Stac protein regulates release of neuropeptides
  I-Uen Hsu, Jeremy W. Linsley, Xiaoli Zhang, Jade E. Varineau, Drew A. Berkhoudt, Lilly E. Reid, Miranda C. Lum, Allison M. Orzel, Ari Leflein, Haoxing Xu, Catherine A. Collins, Richard I. Hume, Edwin S. Levitan, and John Y. Kuwada
  
  PNAS November 24, 2020 117 (47) 29914-29924; first published November 9, 2020. https://doi.org/10.1073/pnas.2009224117
- Open Access
  Oscillations in the central brain of Drosophila are phase locked to attended visual features
  Martyna J. Grabowska, Rhiannon Jeans, James Steeves, and Bruno van Swinderen
  
  PNAS November 24, 2020 117 (47) 29925-29936; first published November 11, 2020. https://doi.org/10.1073/pnas.2010749117
- Open Access
  The potassium channel subunit K_vβ1 serves as a major control point for synaptic facilitation
  In Ha Cho, Lauren C. Panzera, Morven Chin, Scott A. Alpizar, Genaro E. Olveda, Robert A. Hill, and Michael B. Hoppa
  
  PNAS November 24, 2020 117 (47) 29937-29947; first published November 9, 2020. https://doi.org/10.1073/pnas.2000790117
- Open Access
  Characteristics of sequential activity in networks with temporally asymmetric Hebbian learning
  Maxwell Gillett, Ulises Pereira, and Nicolas Brunel
  
  PNAS November 24, 2020 117 (47) 29948-29958; first published November 11, 2020. https://doi.org/10.1073/pnas.1918674117
Pharmacology
- Open Access
  Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist
  Takahiro Kawai, Bingfa Sun, Hitoshi Yoshino, Dan Feng, Yoshiyuki Suzuki, Masanori Fukazawa, Shunsuke Nagao, David B. Wainscott, Aaron D. Showalter, Brian A. Droz, Tong Sun Kobilka, Matthew P. Coghlan, Francis S. Willard, Yoshiki Kawabe, Brian K. Kobilka, and Kyle W. Sloop
  
  PNAS November 24, 2020 117 (47) 29959-29967; first published November 11, 2020. https://doi.org/10.1073/pnas.2014879117
Physiology
- You have access
  Selectivity filter ion binding affinity determines inactivation in a potassium channel
  Céline Boiteux, David J. Posson, Toby W. Allen, and Crina M. Nimigean
  
  PNAS November 24, 2020 117 (47) 29968-29978; first published November 5, 2020. https://doi.org/10.1073/pnas.2009624117
Plant Biology
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  Rerouting of ribosomal proteins into splicing in plant organelles
  Chuande Wang, Rachel Fourdin, Martine Quadrado, Céline Dargel-Graffin, Dimitri Tolleter, David Macherel, and Hakim Mireau
  
  PNAS November 24, 2020 117 (47) 29979-29987; first published November 9, 2020. https://doi.org/10.1073/pnas.2004075117
Psychological and Cognitive Sciences
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  Controversial stimuli: Pitting neural networks against each other as models of human cognition
  Tal Golan, Prashant C. Raju, and Nikolaus Kriegeskorte
  
  PNAS November 24, 2020 117 (47) 29330-29337; first published November 23, 2020. https://doi.org/10.1073/pnas.1912334117
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  Large-scale dissociations between views of objects, scenes, and reachable-scale environments in visual cortex
  Emilie L. Josephs and Talia Konkle
  
  PNAS November 24, 2020 117 (47) 29354-29362; first published November 23, 2020. https://doi.org/10.1073/pnas.1912333117
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  Local reliability weighting explains identification of partially masked objects in natural images
  Stephen Sebastian, Eric S. Seemiller, and Wilson S. Geisler
  
  PNAS November 24, 2020 117 (47) 29363-29370; first published November 23, 2020. https://doi.org/10.1073/pnas.1912331117

Corrections

You have access
Correction for Polymenidou et al., Humoral immune response to native eukaryotic prion protein correlates with anti-prion protection
PNAS November 24, 2020 117 (47) 29988; first published November 9, 2020. https://doi.org/10.1073/pnas.2021354117
You have access
Correction for Huang et al., Mechanism of water extraction from gypsum rock by desert colonizing microorganisms
PNAS November 24, 2020 117 (47) 29989; first published November 9, 2020. https://doi.org/10.1073/pnas.2021524117
You have access
Correction for Kossin et al., Global increase in major tropical cyclone exceedance probability over the past four decades
PNAS November 24, 2020 117 (47) 29990; first published November 9, 2020. https://doi.org/10.1073/pnas.2021573117
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Correction for Goldstein and Lee, Demographic perspectives on the mortality of COVID-19 and other epidemics
PNAS November 24, 2020 117 (47) 29991; first published November 2, 2020. https://doi.org/10.1073/pnas.2021355117

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