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Table of Contents
December 01, 2020; vol. 117 no. 48
Opinion
Leading scientists discuss current issues
- You have accessOpinion: Biodiversity conservation during a global crisis: Consequences and the way forward
- Front Matter
Alok Bang and Suvarna KhadakkarPNAS December 1, 2020 117 (48) 29995-29999; first published November 11, 2020. https://doi.org/10.1073/pnas.2021460117
Profile
The life and work of NAS members
- You have accessProfile of Joel D. BlumJennifer ViegasPNAS December 1, 2020 117 (48) 30000-30002; first published November 23, 2020. https://doi.org/10.1073/pnas.2022416117
See companion article:
Perspective
- You have accessEthics in field experimentation: A call to establish new standards to protect the public from unwanted manipulation and real harmsRose McDermott and Peter K. HatemiPNAS December 1, 2020 117 (48) 30014-30021; first published November 23, 2020. https://doi.org/10.1073/pnas.2012021117
Letters
- Open AccessAspect ratio dependence of the ultimate-state transition in turbulent thermal convectionXiaozhou He, Eberhard Bodenschatz, and Guenter AhlersPNAS December 1, 2020 117 (48) 30022-30023; first published November 24, 2020. https://doi.org/10.1073/pnas.2007399117
- You have accessReply to He et al.: The dependence of heat transport law on aspect ratio is still unclearKartik P. Iyer, Janet D. Scheel, Jörg Schumacher, and Katepalli R. SreenivasanPNAS December 1, 2020 117 (48) 30024; first published November 24, 2020. https://doi.org/10.1073/pnas.2007913117
See companion article:
- Classical 1/3 scaling of convection holds up to Ra = 1015- Mar 25, 2020
- You have accessSafety concerns regarding concomitant use of tocilizumab and glucocorticoids in COVID-19 patientsChengliang Yang, Elizabeth Liu, and Mingyao LiuPNAS December 1, 2020 117 (48) 30025-30026; first published November 12, 2020. https://doi.org/10.1073/pnas.2009253117
- You have accessReply to Yang et al.: Tocilizumab treatment in COVID-19 patients needs the assessment of the disease severity and timely interventionXiaoling Xu, Mingfeng Han, Tiantian Li, Wei Sun, Dongsheng Wang, Binqing Fu, Yonggang Zhou, Xiaohu Zheng, Yun Yang, Xiuyong Li, Xiaohua Zhang, Aijun Pan, and Haiming WeiPNAS December 1, 2020 117 (48) 30027-30028; first published November 12, 2020. https://doi.org/10.1073/pnas.2011616117
See companion article:
Colloquium on the Science of Deep Learning
Introduction
- You have accessThe science of deep learning
- From the Cover
Richard Baraniuk, David Donoho, and Matan GavishPNAS December 1, 2020 117 (48) 30029-30032; first published November 23, 2020. https://doi.org/10.1073/pnas.2020596117
Colloquium Papers
- You have accessThe unreasonable effectiveness of deep learning in artificial intelligenceTerrence J. SejnowskiPNAS December 1, 2020 117 (48) 30033-30038; first published January 28, 2020. https://doi.org/10.1073/pnas.1907373117
- You have accessTheoretical issues in deep networksTomaso Poggio, Andrzej Banburski, and Qianli LiaoPNAS December 1, 2020 117 (48) 30039-30045; first published June 9, 2020. https://doi.org/10.1073/pnas.1907369117
- You have accessEmergent linguistic structure in artificial neural networks trained by self-supervisionChristopher D. Manning, Kevin Clark, John Hewitt, Urvashi Khandelwal, and Omer LevyPNAS December 1, 2020 117 (48) 30046-30054; first published June 3, 2020. https://doi.org/10.1073/pnas.1907367117
- You have accessThe frontier of simulation-based inferenceKyle Cranmer, Johann Brehmer, and Gilles LouppePNAS December 1, 2020 117 (48) 30055-30062; first published May 29, 2020. https://doi.org/10.1073/pnas.1912789117
- You have accessBenign overfitting in linear regressionPeter L. Bartlett, Philip M. Long, Gábor Lugosi, and Alexander TsiglerPNAS December 1, 2020 117 (48) 30063-30070; first published April 24, 2020. https://doi.org/10.1073/pnas.1907378117
- You have accessUnderstanding the role of individual units in a deep neural networkDavid Bau, Jun-Yan Zhu, Hendrik Strobelt, Agata Lapedriza, Bolei Zhou, and Antonio TorralbaPNAS December 1, 2020 117 (48) 30071-30078; first published September 1, 2020. https://doi.org/10.1073/pnas.1907375117
- You have accessFast reinforcement learning with generalized policy updatesAndré Barreto, Shaobo Hou, Diana Borsa, David Silver, and Doina PrecupPNAS December 1, 2020 117 (48) 30079-30087; first published August 17, 2020. https://doi.org/10.1073/pnas.1907370117
- You have accessOn instabilities of deep learning in image reconstruction and the potential costs of AIVegard Antun, Francesco Renna, Clarice Poon, Ben Adcock, and Anders C. HansenPNAS December 1, 2020 117 (48) 30088-30095; first published May 11, 2020. https://doi.org/10.1073/pnas.1907377117
- You have accessAlgorithms as discrimination detectorsJon Kleinberg, Jens Ludwig, Sendhil Mullainathan, and Cass R. SunsteinPNAS December 1, 2020 117 (48) 30096-30100; first published July 28, 2020. https://doi.org/10.1073/pnas.1912790117
Brief Reports
- Open AccessThe effect of tethering on the clearance rate of suspension-feeding planktonAnders Andersen and Thomas KiørboePNAS December 1, 2020 117 (48) 30101-30103; first published November 16, 2020. https://doi.org/10.1073/pnas.2017441117
- Open AccessThe interplay of movement and spatiotemporal variation in transmission degrades pandemic controlNicholas Kortessis, Margaret W. Simon, Michael Barfield, Gregory E. Glass, Burton H. Singer, and Robert D. HoltPNAS December 1, 2020 117 (48) 30104-30106; first published November 10, 2020. https://doi.org/10.1073/pnas.2018286117
Physical Sciences
Applied Mathematics
- You have accessTheoretical issues in deep networksTomaso Poggio, Andrzej Banburski, and Qianli LiaoPNAS December 1, 2020 117 (48) 30039-30045; first published June 9, 2020. https://doi.org/10.1073/pnas.1907369117
- You have accessOn instabilities of deep learning in image reconstruction and the potential costs of AIVegard Antun, Francesco Renna, Clarice Poon, Ben Adcock, and Anders C. HansenPNAS December 1, 2020 117 (48) 30088-30095; first published May 11, 2020. https://doi.org/10.1073/pnas.1907377117
Applied Physical Sciences
- Open AccessHyperchromatic structural color for perceptually enhanced sensing by the naked eyeTahmid H. Talukdar, Bria McCoy, Sarah K. Timmins, Taufiquar Khan, and Judson D. RyckmanPNAS December 1, 2020 117 (48) 30107-30117; first published November 16, 2020. https://doi.org/10.1073/pnas.2009162117
- You have accessHeterogeneity in social and epidemiological factors determines the risk of measles outbreaksPaolo Bosetti, Piero Poletti, Massimo Stella, Bruno Lepri, Stefano Merler, and Manlio De DomenicoPNAS December 1, 2020 117 (48) 30118-30125; first published November 17, 2020. https://doi.org/10.1073/pnas.1920986117
Biophysics and Computational Biology
- You have accessStructure and regulation of the BsYetJ calcium channel in lipid nanodiscsChieh-Chin Li, Te-Yu Kao, Chu-Chun Cheng, and Yun-Wei ChiangPNAS December 1, 2020 117 (48) 30126-30134; first published November 18, 2020. https://doi.org/10.1073/pnas.2014094117
- Open AccessStructure of eukaryotic DNA polymerase δ bound to the PCNA clamp while encircling DNAFengwei Zheng, Roxana E. Georgescu, Huilin Li, and Michael E. O’DonnellPNAS December 1, 2020 117 (48) 30344-30353; first published November 17, 2020. https://doi.org/10.1073/pnas.2017637117
- Open AccessReplisome bypass of a protein-based R-loop block by Pif1Grant D. Schauer, Lisanne M. Spenkelink, Jacob S. Lewis, Olga Yurieva, Stefan H. Mueller, Antoine M. van Oijen, and Michael E. O’DonnellPNAS December 1, 2020 117 (48) 30354-30361; first published November 16, 2020. https://doi.org/10.1073/pnas.2020189117
- Open AccessTight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusionShane J. Caldwell, Ian C. Haydon, Nikoletta Piperidou, Po-Ssu Huang, Matthew J. Bick, H. Sebastian Sjöström, Donald Hilvert, David Baker, and Cathleen ZeymerPNAS December 1, 2020 117 (48) 30362-30369; first published November 17, 2020. https://doi.org/10.1073/pnas.2008535117
- You have accessAn S/T motif controls reversible oligomerization of the Hsp40 chaperone DNAJB6b through subtle reorganization of a β sheet backboneTheodoros K. Karamanos, Vitali Tugarinov, and G. Marius ClorePNAS December 1, 2020 117 (48) 30441-30450; first published November 16, 2020. https://doi.org/10.1073/pnas.2020306117
- You have accessMarkov state modeling reveals alternative unbinding pathways for peptide–MHC complexesJayvee R. Abella, Dinler Antunes, Kyle Jackson, Gregory Lizée, Cecilia Clementi, and Lydia E. KavrakiPNAS December 1, 2020 117 (48) 30610-30618; first published November 12, 2020. https://doi.org/10.1073/pnas.2007246117
- Open AccessmGreenLantern: a bright monomeric fluorescent protein with rapid expression and cell filling properties for neuronal imagingBenjamin C. Campbell, Elisa M. Nabel, Mitchell H. Murdock, Cristina Lao-Peregrin, Pantelis Tsoulfas, Murray G. Blackmore, Francis S. Lee, Conor Liston, Hirofumi Morishita, and Gregory A. PetskoPNAS December 1, 2020 117 (48) 30710-30721; first published November 18, 2020. https://doi.org/10.1073/pnas.2000942117
Chemistry
- You have accessStable metal anodes enabled by a labile organic molecule bonded to a reduced graphene oxide aerogelYue Gao, Daiwei Wang, Yun Kyung Shin, Zhifei Yan, Zhuo Han, Ke Wang, Md Jamil Hossain, Shuling Shen, Atif AlZahrani, Adri C. T. van Duin, Thomas E. Mallouk, and Donghai WangPNAS December 1, 2020 117 (48) 30135-30141; first published November 16, 2020. https://doi.org/10.1073/pnas.2001837117
- You have accessA chemical dynamics study on the gas-phase formation of triplet and singlet C5H2 carbenesChao He, Galiya R. Galimova, Yuheng Luo, Long Zhao, André K. Eckhardt, Rui Sun, Alexander M. Mebel, and Ralf I. KaiserPNAS December 1, 2020 117 (48) 30142-30150; first published November 16, 2020. https://doi.org/10.1073/pnas.2019257117
- You have accessAbsolute ion hydration free energy scale and the surface potential of water via quantum simulationYu Shi and Thomas L. BeckPNAS December 1, 2020 117 (48) 30151-30158; first published November 17, 2020. https://doi.org/10.1073/pnas.2017214117
Computer Sciences
- You have accessThe unreasonable effectiveness of deep learning in artificial intelligenceTerrence J. SejnowskiPNAS December 1, 2020 117 (48) 30033-30038; first published January 28, 2020. https://doi.org/10.1073/pnas.1907373117
- You have accessEmergent linguistic structure in artificial neural networks trained by self-supervisionChristopher D. Manning, Kevin Clark, John Hewitt, Urvashi Khandelwal, and Omer LevyPNAS December 1, 2020 117 (48) 30046-30054; first published June 3, 2020. https://doi.org/10.1073/pnas.1907367117
- You have accessUnderstanding the role of individual units in a deep neural networkDavid Bau, Jun-Yan Zhu, Hendrik Strobelt, Agata Lapedriza, Bolei Zhou, and Antonio TorralbaPNAS December 1, 2020 117 (48) 30071-30078; first published September 1, 2020. https://doi.org/10.1073/pnas.1907375117
- You have accessFast reinforcement learning with generalized policy updatesAndré Barreto, Shaobo Hou, Diana Borsa, David Silver, and Doina PrecupPNAS December 1, 2020 117 (48) 30079-30087; first published August 17, 2020. https://doi.org/10.1073/pnas.1907370117
- You have accessAlgorithms as discrimination detectorsJon Kleinberg, Jens Ludwig, Sendhil Mullainathan, and Cass R. SunsteinPNAS December 1, 2020 117 (48) 30096-30100; first published July 28, 2020. https://doi.org/10.1073/pnas.1912790117
Earth, Atmospheric, and Planetary Sciences
- Open AccessFrom particle attachment to space-filling coral skeletonsChang-Yu Sun, Cayla A. Stifler, Rajesh V. Chopdekar, Connor A. Schmidt, Ganesh Parida, Vanessa Schoeppler, Benjamin I. Fordyce, Jack H. Brau, Tali Mass, Sylvie Tambutté, and Pupa U. P. A. GilbertPNAS December 1, 2020 117 (48) 30159-30170; first published November 13, 2020. https://doi.org/10.1073/pnas.2012025117
- You have accessMolecular and isotopic evidence reveals the end-Triassic carbon isotope excursion is not from massive exogenous light carbonCalum P. Fox, Xingqian Cui, Jessica H. Whiteside, Paul E. Olsen, Roger E. Summons, and Kliti GricePNAS December 1, 2020 117 (48) 30171-30178; first published November 16, 2020. https://doi.org/10.1073/pnas.1917661117
- You have accessSolar geoengineering may not prevent strong warming from direct effects of CO2 on stratocumulus cloud coverTapio Schneider, Colleen M. Kaul, and Kyle G. PresselPNAS December 1, 2020 117 (48) 30179-30185; first published November 16, 2020. https://doi.org/10.1073/pnas.2003730117
Engineering
- You have accessDirac cones and chiral selection of elastic waves in a soft stripMaxime Lanoy, Fabrice Lemoult, Antonin Eddi, and Claire PradaPNAS December 1, 2020 117 (48) 30186-30190; first published November 18, 2020. https://doi.org/10.1073/pnas.2010812117
- You have accessIonization behavior of nanoporous polyamide membranesCody L. Ritt, Jay R. Werber, Mengyi Wang, Zhongyue Yang, Yumeng Zhao, Heather J. Kulik, and Menachem ElimelechPNAS December 1, 2020 117 (48) 30191-30200; first published November 12, 2020. https://doi.org/10.1073/pnas.2008421117
- You have accessSwimming microorganisms acquire optimal efficiency with multiple ciliaToshihiro Omori, Hiroaki Ito, and Takuji IshikawaPNAS December 1, 2020 117 (48) 30201-30207; first published November 16, 2020. https://doi.org/10.1073/pnas.2011146117
- You have accessConstitutive relationship and governing physical properties for magnetophoresisAyankola O. Ayansiji, Anish V. Dighe, Andreas A. Linninger, and Meenesh R. SinghPNAS December 1, 2020 117 (48) 30208-30214; first published November 17, 2020. https://doi.org/10.1073/pnas.2018568117
Physics
- Open AccessCritical point for Bose–Einstein condensation of excitons in graphiteJinhua Wang, Pan Nie, Xiaokang Li, Huakun Zuo, Benoît Fauqué, Zengwei Zhu, and Kamran BehniaPNAS December 1, 2020 117 (48) 30215-30219; first published November 16, 2020. https://doi.org/10.1073/pnas.2012811117
- Open AccessFrom antiferromagnetic and hidden order to Pauli paramagnetism in UM2Si2 compounds with 5f electron dualityAndrea Amorese, Martin Sundermann, Brett Leedahl, Andrea Marino, Daisuke Takegami, Hlynur Gretarsson, Andrei Gloskovskii, Christoph Schlueter, Maurits W. Haverkort, Yingkai Huang, Maria Szlawska, Dariusz Kaczorowski, Sheng Ran, M. Brian Maple, Eric D. Bauer, Andreas Leithe-Jasper, Philipp Hansmann, Peter Thalmeier, Liu Hao Tjeng, and Andrea SeveringPNAS December 1, 2020 117 (48) 30220-30227; first published November 17, 2020. https://doi.org/10.1073/pnas.2005701117
- Open AccessFlow-induced choking of a compliant Hele-Shaw cellFinn Box, Gunnar G. Peng, Draga Pihler-Puzović, and Anne JuelPNAS December 1, 2020 117 (48) 30228-30233; first published November 16, 2020. https://doi.org/10.1073/pnas.2008273117
- You have accessMachine-learning iterative calculation of entropy for physical systemsAmit Nir, Eran Sela, Roy Beck, and Yohai Bar-SinaiPNAS December 1, 2020 117 (48) 30234-30240; first published November 19, 2020. https://doi.org/10.1073/pnas.2017042117
- You have accessMultiscale structural complexity of natural patternsAndrey A. Bagrov, Ilia A. Iakovlev, Askar A. Iliasov, Mikhail I. Katsnelson, and Vladimir V. MazurenkoPNAS December 1, 2020 117 (48) 30241-30251; first published November 18, 2020. https://doi.org/10.1073/pnas.2004976117
- You have accessHidden symmetries generate rigid folding mechanisms in periodic origamiJames McInerney, Bryan Gin-ge Chen, Louis Theran, Christian D. Santangelo, and D. Zeb RocklinPNAS December 1, 2020 117 (48) 30252-30259; first published November 16, 2020. https://doi.org/10.1073/pnas.2005089117
- You have accessTopological Weaire–Thorpe models of amorphous matterQuentin Marsal, Dániel Varjas, and Adolfo G. GrushinPNAS December 1, 2020 117 (48) 30260-30265; first published November 18, 2020. https://doi.org/10.1073/pnas.2007384117
Statistics
- You have accessThe frontier of simulation-based inferenceKyle Cranmer, Johann Brehmer, and Gilles LouppePNAS December 1, 2020 117 (48) 30055-30062; first published May 29, 2020. https://doi.org/10.1073/pnas.1912789117
- You have accessBenign overfitting in linear regressionPeter L. Bartlett, Philip M. Long, Gábor Lugosi, and Alexander TsiglerPNAS December 1, 2020 117 (48) 30063-30070; first published April 24, 2020. https://doi.org/10.1073/pnas.1907378117
- Open AccessMethods for correcting inference based on outcomes predicted by machine learningSiruo Wang, Tyler H. McCormick, and Jeffrey T. LeekPNAS December 1, 2020 117 (48) 30266-30275; first published November 18, 2020. https://doi.org/10.1073/pnas.2001238117
- Open AccessEstimating and forecasting spatial population dynamics of apex predators using transnational genetic monitoringRichard Bischof, Cyril Milleret, Pierre Dupont, Joseph Chipperfield, Mahdieh Tourani, Andrés Ordiz, Perry de Valpine, Daniel Turek, J. Andrew Royle, Olivier Gimenez, Øystein Flagstad, Mikael Åkesson, Linn Svensson, Henrik Brøseth, and Jonas KindbergPNAS December 1, 2020 117 (48) 30531-30538; first published November 16, 2020. https://doi.org/10.1073/pnas.2011383117
Social Sciences
Anthropology
- You have accessMatriliny reverses gender disparities in inflammation and hypertension among the Mosuo of ChinaAdam Z. Reynolds, Katherine Wander, Chun-Yi Sum, Mingjie Su, Melissa Emery Thompson, Paul L. Hooper, Hui Li, Mary K. Shenk, Kathrine E. Starkweather, Tami Blumenfield, and Siobhán M. MattisonPNAS December 1, 2020 117 (48) 30324-30327; first published November 16, 2020. https://doi.org/10.1073/pnas.2014403117
Psychological and Cognitive Sciences
- Open AccessReconciling print-size and display-size constraints on reading
- From the Cover
Nilsu Atilgan, Ying-Zi Xiong, and Gordon E. LeggePNAS December 1, 2020 117 (48) 30276-30284; first published November 9, 2020. https://doi.org/10.1073/pnas.2007514117
Social Sciences
- Open AccessNetwork interventions for managing the COVID-19 pandemic and sustaining economyAkihiro Nishi, George Dewey, Akira Endo, Sophia Neman, Sage K. Iwamoto, Michael Y. Ni, Yusuke Tsugawa, Georgios Iosifidis, Justin D. Smith, and Sean D. YoungPNAS December 1, 2020 117 (48) 30285-30294; first published November 11, 2020. https://doi.org/10.1073/pnas.2014297117
See companion article:
- Considering network interventions- Dec 21, 2020
- Open AccessThe social patterning of autism diagnoses reversed in California between 1992 and 2018Alix S. Winter, Christine Fountain, Keely Cheslack-Postava, and Peter S. BearmanPNAS December 1, 2020 117 (48) 30295-30302; first published November 16, 2020. https://doi.org/10.1073/pnas.2015762117
- Open AccessThe confidence gap predicts the gender pay gap among STEM graduates
- From the Cover
Adina D. Sterling, Marissa E. Thompson, Shiya Wang, Abisola Kusimo, Shannon Gilmartin, and Sheri SheppardPNAS December 1, 2020 117 (48) 30303-30308; first published November 16, 2020. https://doi.org/10.1073/pnas.2010269117 - You have accessThe changing geography of social mobility in the United StatesDylan Shane Connor and Michael StorperPNAS December 1, 2020 117 (48) 30309-30317; first published November 16, 2020. https://doi.org/10.1073/pnas.2010222117
Sustainability Science
- Open AccessConsequences of seafood mislabeling for marine populations and fisheries managementKailin Kroetz, Gloria M. Luque, Jessica A. Gephart, Sunny L. Jardine, Patrick Lee, Katrina Chicojay Moore, Cassandra Cole, Andrew Steinkruger, and C. Josh DonlanPNAS December 1, 2020 117 (48) 30318-30323; first published November 16, 2020. https://doi.org/10.1073/pnas.2003741117
Biological Sciences
Anthropology
- You have accessMatriliny reverses gender disparities in inflammation and hypertension among the Mosuo of ChinaAdam Z. Reynolds, Katherine Wander, Chun-Yi Sum, Mingjie Su, Melissa Emery Thompson, Paul L. Hooper, Hui Li, Mary K. Shenk, Kathrine E. Starkweather, Tami Blumenfield, and Siobhán M. MattisonPNAS December 1, 2020 117 (48) 30324-30327; first published November 16, 2020. https://doi.org/10.1073/pnas.2014403117
Applied Biological Sciences
- You have accessGlutaric acid production by systems metabolic engineering of an l-lysine–overproducing Corynebacterium glutamicumTaehee Han, Gi Bae Kim, and Sang Yup LeePNAS December 1, 2020 117 (48) 30328-30334; first published November 16, 2020. https://doi.org/10.1073/pnas.2017483117
- You have accessDelivery of muscle-derived exosomal miRNAs induced by HIIT improves insulin sensitivity through down-regulation of hepatic FoxO1 in miceCarlos Castaño, Mercedes Mirasierra, Mario Vallejo, Anna Novials, and Marcelina PárrizasPNAS December 1, 2020 117 (48) 30335-30343; first published November 16, 2020. https://doi.org/10.1073/pnas.2016112117
Biochemistry
- You have accessStructure and regulation of the BsYetJ calcium channel in lipid nanodiscsChieh-Chin Li, Te-Yu Kao, Chu-Chun Cheng, and Yun-Wei ChiangPNAS December 1, 2020 117 (48) 30126-30134; first published November 18, 2020. https://doi.org/10.1073/pnas.2014094117
- Open AccessStructure of eukaryotic DNA polymerase δ bound to the PCNA clamp while encircling DNAFengwei Zheng, Roxana E. Georgescu, Huilin Li, and Michael E. O’DonnellPNAS December 1, 2020 117 (48) 30344-30353; first published November 17, 2020. https://doi.org/10.1073/pnas.2017637117
- Open AccessReplisome bypass of a protein-based R-loop block by Pif1Grant D. Schauer, Lisanne M. Spenkelink, Jacob S. Lewis, Olga Yurieva, Stefan H. Mueller, Antoine M. van Oijen, and Michael E. O’DonnellPNAS December 1, 2020 117 (48) 30354-30361; first published November 16, 2020. https://doi.org/10.1073/pnas.2020189117
- Open AccessTight and specific lanthanide binding in a de novo TIM barrel with a large internal cavity designed by symmetric domain fusionShane J. Caldwell, Ian C. Haydon, Nikoletta Piperidou, Po-Ssu Huang, Matthew J. Bick, H. Sebastian Sjöström, Donald Hilvert, David Baker, and Cathleen ZeymerPNAS December 1, 2020 117 (48) 30362-30369; first published November 17, 2020. https://doi.org/10.1073/pnas.2008535117
- You have accessStructure-function analysis of microRNA 3′-end trimming by NibblerWei Xie, Ivica Sowemimo, Rippei Hayashi, Juncheng Wang, Thomas R. Burkard, Julius Brennecke, Stefan L. Ameres, and Dinshaw J. PatelPNAS December 1, 2020 117 (48) 30370-30379; first published November 16, 2020. https://doi.org/10.1073/pnas.2018156117
- You have accessCrystal structure of a guanine nucleotide exchange factor encoded by the scrub typhus pathogen Orientia tsutsugamushiChristopher Lim, Jason M. Berk, Alyssa Blaise, Josie Bircher, Anthony J. Koleske, Mark Hochstrasser, and Yong XiongPNAS December 1, 2020 117 (48) 30380-30390; first published November 12, 2020. https://doi.org/10.1073/pnas.2018163117
- You have accessNAP1-Related Protein 1 (NRP1) has multiple interaction modes for chaperoning histones H2A-H2BQiang Luo, Baihui Wang, Zhen Wu, Wen Jiang, Yueyue Wang, Kangxi Du, Nana Zhou, Lina Zheng, Jianhua Gan, Wen-Hui Shen, Jinbiao Ma, and Aiwu DongPNAS December 1, 2020 117 (48) 30391-30399; first published November 16, 2020. https://doi.org/10.1073/pnas.2011089117
- You have accessFMRP links optimal codons to mRNA stability in neuronsHuan Shu, Elisa Donnard, Botao Liu, Suna Jung, Ruijia Wang, and Joel D. RichterPNAS December 1, 2020 117 (48) 30400-30411; first published November 16, 2020. https://doi.org/10.1073/pnas.2009161117
- You have accessMobile loop dynamics in adenosyltransferase control binding and reactivity of coenzyme B12Romila Mascarenhas, Markus Ruetz, Liam McDevitt, Markos Koutmos, and Ruma BanerjeePNAS December 1, 2020 117 (48) 30412-30422; first published November 16, 2020. https://doi.org/10.1073/pnas.2007332117
- You have accessThe antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymeraseMirjana Lilic, James Chen, Hande Boyaci, Nathaniel Braffman, Elizabeth A. Hubin, Jennifer Herrmann, Rolf Müller, Rachel Mooney, Robert Landick, Seth A. Darst, and Elizabeth A. CampbellPNAS December 1, 2020 117 (48) 30423-30432; first published November 16, 2020. https://doi.org/10.1073/pnas.2013706117
- You have accessInterface switch mediates signal transmission in a two-component systemMingxing Wang, Qiong Guo, Kongfu Zhu, Bo Fang, Yifan Yang, Maikun Teng, Xu Li, and Yuyong TaoPNAS December 1, 2020 117 (48) 30433-30440; first published November 16, 2020. https://doi.org/10.1073/pnas.1912080117
Biophysics and Computational Biology
- Open AccessFrom particle attachment to space-filling coral skeletonsChang-Yu Sun, Cayla A. Stifler, Rajesh V. Chopdekar, Connor A. Schmidt, Ganesh Parida, Vanessa Schoeppler, Benjamin I. Fordyce, Jack H. Brau, Tali Mass, Sylvie Tambutté, and Pupa U. P. A. GilbertPNAS December 1, 2020 117 (48) 30159-30170; first published November 13, 2020. https://doi.org/10.1073/pnas.2012025117
- You have accessAn S/T motif controls reversible oligomerization of the Hsp40 chaperone DNAJB6b through subtle reorganization of a β sheet backboneTheodoros K. Karamanos, Vitali Tugarinov, and G. Marius ClorePNAS December 1, 2020 117 (48) 30441-30450; first published November 16, 2020. https://doi.org/10.1073/pnas.2020306117
- You have accessBiophysical analysis of the structural evolution of substrate specificity in RuBisCOSaroj Poudel, Douglas H. Pike, Hagai Raanan, Joshua A. Mancini, Vikas Nanda, Rosalind E. M. Rickaby, and Paul G. FalkowskiPNAS December 1, 2020 117 (48) 30451-30457; first published November 16, 2020. https://doi.org/10.1073/pnas.2018939117
- You have accessStructural basis for polarized elongation of actin filamentsVilmos Zsolnay, Harshwardhan H. Katkar, Steven Z. Chou, Thomas D. Pollard, and Gregory A. VothPNAS December 1, 2020 117 (48) 30458-30464; first published November 16, 2020. https://doi.org/10.1073/pnas.2011128117
- Open AccessSingle-molecule and in silico dissection of the interaction between Polycomb repressive complex 2 and chromatinRachel Leicher, Eva J. Ge, Xingcheng Lin, Matthew J. Reynolds, Wenjun Xie, Thomas Walz, Bin Zhang, Tom W. Muir, and Shixin LiuPNAS December 1, 2020 117 (48) 30465-30475; first published November 18, 2020. https://doi.org/10.1073/pnas.2003395117
Cell Biology
- You have accessModular transient nanoclustering of activated β2-adrenergic receptors revealed by single-molecule tracking of conformation-specific nanobodiesRachel S. Gormal, Pranesh Padmanabhan, Ravikiran Kasula, Adekunle T. Bademosi, Sean Coakley, Jean Giacomotto, Ailisa Blum, Merja Joensuu, Tristan P. Wallis, Harriet P. Lo, Srikanth Budnar, James Rae, Charles Ferguson, Michele Bastiani, Walter G. Thomas, Els Pardon, Jan Steyaert, Alpha S. Yap, Geoffrey J. Goodhill, Massimo A. Hilliard, Robert G. Parton, and Frédéric A. MeunierPNAS December 1, 2020 117 (48) 30476-30487; first published November 19, 2020. https://doi.org/10.1073/pnas.2007443117
- You have accessFoxO1 is a crucial mediator of TGF-β/TAK1 signaling and protects against osteoarthritis by maintaining articular cartilage homeostasisCuicui Wang, Jie Shen, Jun Ying, Ding Xiao, and Regis J. O’KeefePNAS December 1, 2020 117 (48) 30488-30497; first published November 16, 2020. https://doi.org/10.1073/pnas.2017056117
- You have accessThe Cockayne syndrome group A and B proteins are part of a ubiquitin–proteasome degradation complex regulating cell divisionElena Paccosi, Federico Costanzo, Michele Costantino, Alessio Balzerano, Laura Monteonofrio, Silvia Soddu, Giorgio Prantera, Stefano Brancorsini, Jean-Marc Egly, and Luca Proietti-De-SantisPNAS December 1, 2020 117 (48) 30498-30508; first published November 16, 2020. https://doi.org/10.1073/pnas.2006543117
Developmental Biology
- Open AccessMammalian-specific ectodermal enhancers control the expression of Hoxc genes in developing nails and hair folliclesMarc Fernandez-Guerrero, Nayuta Yakushiji-Kaminatsui, Lucille Lopez-Delisle, Sofía Zdral, Fabrice Darbellay, Rocío Perez-Gomez, Christopher Chase Bolt, Manuel A. Sanchez-Martin, Denis Duboule, and Marian A. RosPNAS December 1, 2020 117 (48) 30509-30519; first published November 16, 2020. https://doi.org/10.1073/pnas.2011078117
- You have accessRox8 promotes microRNA-dependent yki messenger RNA decayXiaowei Guo, Yihao Sun, Taha Azad, H. J. Janse van Rensburg, Jingjing Luo, Shuai Yang, Peng Liu, Zhongwei Lv, Meixiao Zhan, Ligong Lu, Yingqun Zhou, Xianjue Ma, Xiaoping Zhang, Xiaolong Yang, and Lei XuePNAS December 1, 2020 117 (48) 30520-30530; first published November 17, 2020. https://doi.org/10.1073/pnas.2013449117
Ecology
- Open AccessEstimating and forecasting spatial population dynamics of apex predators using transnational genetic monitoringRichard Bischof, Cyril Milleret, Pierre Dupont, Joseph Chipperfield, Mahdieh Tourani, Andrés Ordiz, Perry de Valpine, Daniel Turek, J. Andrew Royle, Olivier Gimenez, Øystein Flagstad, Mikael Åkesson, Linn Svensson, Henrik Brøseth, and Jonas KindbergPNAS December 1, 2020 117 (48) 30531-30538; first published November 16, 2020. https://doi.org/10.1073/pnas.2011383117
- You have accessParental benefits and offspring costs reflect parent–offspring conflict over the age of fledging among songbirdsTodd M. Jones, Jeffrey D. Brawn, Ian J. Ausprey, Andrew C. Vitz, Amanda D. Rodewald, Douglas W. Raybuck, Than J. Boves, Cameron J. Fiss, Darin J. McNeil, Scott H. Stoleson, Jeffery L. Larkin, W. Andrew Cox, Amy C. Schwarzer, Noah P. Horsley, Evalynn M. Trumbo, and Michael P. WardPNAS December 1, 2020 117 (48) 30539-30546; first published November 16, 2020. https://doi.org/10.1073/pnas.2008955117
- You have accessThe impact of COVID-19 nonpharmaceutical interventions on the future dynamics of endemic infectionsRachel E. Baker, Sang Woo Park, Wenchang Yang, Gabriel A. Vecchi, C. Jessica E. Metcalf, and Bryan T. GrenfellPNAS December 1, 2020 117 (48) 30547-30553; first published November 9, 2020. https://doi.org/10.1073/pnas.2013182117
Evolution
- You have accessGenomic islands of differentiation in a rapid avian radiation have been driven by recent selective sweepsHussein A. Hejase, Ayelet Salman-Minkov, Leonardo Campagna, Melissa J. Hubisz, Irby J. Lovette, Ilan Gronau, and Adam SiepelPNAS December 1, 2020 117 (48) 30554-30565; first published November 16, 2020. https://doi.org/10.1073/pnas.2015987117
Genetics
- You have accessAneuploidy increases resistance to chemotherapeutics by antagonizing cell divisionJohn Michael Replogle, Wen Zhou, Adrianna E. Amaro, James M. McFarland, Mariana Villalobos-Ortiz, Jeremy Ryan, Anthony Letai, Omer Yilmaz, Jason Sheltzer, Stephen J. Lippard, Uri Ben-David, and Angelika AmonPNAS December 1, 2020 117 (48) 30566-30576; first published November 17, 2020. https://doi.org/10.1073/pnas.2009506117
- You have accessExo1 recruits Cdc5 polo kinase to MutLγ to ensure efficient meiotic crossover formationAurore Sanchez, Céline Adam, Felix Rauh, Yann Duroc, Lepakshi Ranjha, Bérangère Lombard, Xiaojing Mu, Mélody Wintrebert, Damarys Loew, Alba Guarné, Stefano Gnan, Chun-Long Chen, Scott Keeney, Petr Cejka, Raphaël Guérois, Franz Klein, Jean-Baptiste Charbonnier, and Valérie BordePNAS December 1, 2020 117 (48) 30577-30588; first published November 16, 2020. https://doi.org/10.1073/pnas.2013012117
- You have accessA microbial metabolite synergizes with endogenous serotonin to trigger C. elegans reproductive behaviorYen-Chih Chen, Mohammad R. Seyedsayamdost, and Niels RingstadPNAS December 1, 2020 117 (48) 30589-30598; first published November 16, 2020. https://doi.org/10.1073/pnas.2017918117
- You have accessIncompatibility between proliferation and plant invasion is mediated by a regulator of appressorium formation in the corn smut fungus Ustilago maydisAntonio de la Torre, Sónia Castanheira, and José Pérez-MartínPNAS December 1, 2020 117 (48) 30599-30609; first published November 16, 2020. https://doi.org/10.1073/pnas.2006909117
Immunology and Inflammation
- You have accessMarkov state modeling reveals alternative unbinding pathways for peptide–MHC complexesJayvee R. Abella, Dinler Antunes, Kyle Jackson, Gregory Lizée, Cecilia Clementi, and Lydia E. KavrakiPNAS December 1, 2020 117 (48) 30610-30618; first published November 12, 2020. https://doi.org/10.1073/pnas.2007246117
- You have accessLeukotriene B4 licenses inflammasome activation to enhance skin host defenseAna Carolina Guerta Salina, Stephanie L. Brandt, Nathan Klopfenstein, Amondrea Blackman, Júlia Miranda Ribeiro Bazzano, Anderson Sá-Nunes, Nicole Byers-Glosson, Claudia Brodskyn, Natalia Machado Tavares, Icaro Bonyek Santos Da Silva, Alexandra I. Medeiros, and C. Henrique SerezaniPNAS December 1, 2020 117 (48) 30619-30627; first published November 12, 2020. https://doi.org/10.1073/pnas.2002732117
- You have accessTLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylationRicardo A. Irizarry-Caro, Margaret M. McDaniel, Garrett R. Overcast, Viral G. Jain, Ty Dale Troutman, and Chandrashekhar PasarePNAS December 1, 2020 117 (48) 30628-30638; first published November 16, 2020. https://doi.org/10.1073/pnas.2009778117
- Open AccessAberrant expression of USF2 in refractory rheumatoid arthritis and its regulation of proinflammatory cytokines in Th17 cellsDan Hu, Emily C. Tjon, Karin M. Andersson, Gabriela M. Molica, Minh C. Pham, Brian Healy, Gopal Murugaiyan, Nathalie Pochet, Vijay K. Kuchroo, Maria I. Bokarewa, and Howard L. WeinerPNAS December 1, 2020 117 (48) 30639-30648; first published November 17, 2020. https://doi.org/10.1073/pnas.2007935117
- You have accessThymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravisRuoyi Jiang, Kenneth B. Hoehn, Casey S. Lee, Minh C. Pham, Robert J. Homer, Frank C. Detterbeck, Inmaculada Aban, Leslie Jacobson, Angela Vincent, Richard J. Nowak, Henry J. Kaminski, Steven H. Kleinstein, and Kevin C. O’ConnorPNAS December 1, 2020 117 (48) 30649-30660; first published November 16, 2020. https://doi.org/10.1073/pnas.2007206117
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- Thymectomy and myasthenia gravis- Dec 03, 2020
Medical Sciences
- Open AccessLabel-free adaptive optics imaging of human retinal macrophage distribution and dynamicsDaniel X. Hammer, Anant Agrawal, Ricardo Villanueva, Osamah Saeedi, and Zhuolin LiuPNAS December 1, 2020 117 (48) 30661-30669; first published November 9, 2020. https://doi.org/10.1073/pnas.2010943117
- Open AccessUnbiased in vivo preclinical evaluation of anticancer drugs identifies effective therapy for the treatment of pancreatic adenocarcinomaOlivera Grbovic-Huezo, Kenneth L. Pitter, Nicolas Lecomte, Joseph Saglimbeni, Gokce Askan, Matilda Holm, Jerry P. Melchor, Rohit Chandwani, Suhasini Joshi, Caj Haglund, Christine A. Iacobuzio-Donahue, Gabriela Chiosis, Tuomas Tammela, and Steven D. LeachPNAS December 1, 2020 117 (48) 30670-30678; first published November 16, 2020. https://doi.org/10.1073/pnas.1920240117
Microbiology
- Open AccessAnalysis of genomic distributions of SARS-CoV-2 reveals a dominant strain type with strong allelic associationsHsin-Chou Yang, Chun-houh Chen, Jen-Hung Wang, Hsiao-Chi Liao, Chih-Ting Yang, Chia-Wei Chen, Yin-Chun Lin, Chiun-How Kao, Mei-Yeh Jade Lu, and James C. LiaoPNAS December 1, 2020 117 (48) 30679-30686; first published November 12, 2020. https://doi.org/10.1073/pnas.2007840117
- You have accessThe SKI complex is a broad-spectrum, host-directed antiviral drug target for coronaviruses, influenza, and filovirusesStuart Weston, Lauren Baracco, Chloe Keller, Krystal Matthews, Marisa E. McGrath, James Logue, Janie Liang, Julie Dyall, Michael R. Holbrook, Lisa E. Hensley, Peter B. Jahrling, Wenbo Yu, Alexander D. MacKerell Jr, and Matthew B. FriemanPNAS December 1, 2020 117 (48) 30687-30698; first published November 12, 2020. https://doi.org/10.1073/pnas.2012939117
- You have accessTranscriptome-based design of antisense inhibitors potentiates carbapenem efficacy in CRE Escherichia coliThomas R. Aunins, Keesha E. Erickson, and Anushree ChatterjeePNAS December 1, 2020 117 (48) 30699-30709; first published November 16, 2020. https://doi.org/10.1073/pnas.1922187117
Neuroscience
- You have accessThe unreasonable effectiveness of deep learning in artificial intelligenceTerrence J. SejnowskiPNAS December 1, 2020 117 (48) 30033-30038; first published January 28, 2020. https://doi.org/10.1073/pnas.1907373117
- Open AccessmGreenLantern: a bright monomeric fluorescent protein with rapid expression and cell filling properties for neuronal imagingBenjamin C. Campbell, Elisa M. Nabel, Mitchell H. Murdock, Cristina Lao-Peregrin, Pantelis Tsoulfas, Murray G. Blackmore, Francis S. Lee, Conor Liston, Hirofumi Morishita, and Gregory A. PetskoPNAS December 1, 2020 117 (48) 30710-30721; first published November 18, 2020. https://doi.org/10.1073/pnas.2000942117
- Open AccessFast recovery of disrupted tip links induced by mechanical displacement of hair bundlesR. G. Alonso, M. Tobin, P. Martin, and A. J. HudspethPNAS December 1, 2020 117 (48) 30722-30727; first published November 16, 2020. https://doi.org/10.1073/pnas.2016858117
- You have accessEvidence accumulation for value computation in the prefrontal cortex during decision makingZhongqiao Lin, Chechang Nie, Yuanfeng Zhang, Yang Chen, and Tianming YangPNAS December 1, 2020 117 (48) 30728-30737; first published November 16, 2020. https://doi.org/10.1073/pnas.2019077117
- You have accessMaternally inherited peptides as strain-specific chemosignalsHideto Kaba, Hiroko Fujita, Takeshi Agatsuma, and Hiroaki MatsunamiPNAS December 1, 2020 117 (48) 30738-30743; first published November 16, 2020. https://doi.org/10.1073/pnas.2014712117
- Open AccessThirst recruits phasic dopamine signaling through subfornical organ neuronsTed M. Hsu, Paula Bazzino, Samantha J. Hurh, Vaibhav R. Konanur, Jamie D. Roitman, and Mitchell F. RoitmanPNAS December 1, 2020 117 (48) 30744-30754; first published November 16, 2020. https://doi.org/10.1073/pnas.2009233117
Pharmacology
- Open AccessAn inactive receptor-G protein complex maintains the dynamic range of agonist-induced signalingWonjo Jang, C. Elizabeth Adams, Heng Liu, Cheng Zhang, Finn Olav Levy, Kjetil Wessel Andressen, and Nevin A. LambertPNAS December 1, 2020 117 (48) 30755-30762; first published November 16, 2020. https://doi.org/10.1073/pnas.2010801117
Physiology
- You have accessDirac cones and chiral selection of elastic waves in a soft stripMaxime Lanoy, Fabrice Lemoult, Antonin Eddi, and Claire PradaPNAS December 1, 2020 117 (48) 30186-30190; first published November 18, 2020. https://doi.org/10.1073/pnas.2010812117
- You have accessLack of adipocyte purinergic P2Y6 receptor greatly improves whole body glucose homeostasisShanu Jain, Sai P. Pydi, Kiran S. Toti, Bernard Robaye, Marco Idzko, Oksana Gavrilova, Jürgen Wess, and Kenneth A. JacobsonPNAS December 1, 2020 117 (48) 30763-30774; first published November 16, 2020. https://doi.org/10.1073/pnas.2006578117
- Open AccessThe intracellular Ca2+ release channel TRPML1 regulates lower urinary tract smooth muscle contractility
- From the Cover
Caoimhin S. Griffin, Michael G. Alvarado, Evan Yamasaki, Bernard T. Drumm, Vivek Krishnan, Sher Ali, Eleanor M. Nagle, Kenton M. Sanders, and Scott EarleyPNAS December 1, 2020 117 (48) 30775-30786; first published November 16, 2020. https://doi.org/10.1073/pnas.2016959117See companion article:
- Igniting Ca2+ sparks with TRPML1- Dec 01, 2020
- You have accessAllosteric modulation of alternatively spliced Ca2+-activated Cl− channels TMEM16A by PI(4,5)P2 and CaMKIIWoori Ko, Seung-Ryoung Jung, Kwon-Woo Kim, Jun-Hee Yeon, Cheon-Gyu Park, Joo Hyun Nam, Bertil Hille, and Byung-Chang SuhPNAS December 1, 2020 117 (48) 30787-30798; first published November 16, 2020. https://doi.org/10.1073/pnas.2014520117
Plant Biology
- You have accessBroad noncoding transcription suggests genome surveillance by RNA polymerase VMasayuki Tsuzuki, Shriya Sethuraman, Adriana N. Coke, M. Hafiz Rothi, Alan P. Boyle, and Andrzej T. WierzbickiPNAS December 1, 2020 117 (48) 30799-30804; first published November 16, 2020. https://doi.org/10.1073/pnas.2014419117
- Open AccessHOS15 is a transcriptional corepressor of NPR1-mediated gene activation of plant immunityMingzhe Shen, Chae Jin Lim, Junghoon Park, Jeong Eun Kim, Dongwon Baek, Jaesung Nam, Sang Yeol Lee, Jose M. Pardo, Woe-Yeon Kim, David Mackey, and Dae-Jin YunPNAS December 1, 2020 117 (48) 30805-30815; first published November 16, 2020. https://doi.org/10.1073/pnas.2016049117
- You have accessDissection of the general two-step di-C-glycosylation pathway for the biosynthesis of (iso)schaftosides in higher plantsZi-Long Wang, Hao-Meng Gao, Shuang Wang, Meng Zhang, Kuan Chen, Ya-Qun Zhang, Hai-Dong Wang, Bo-Yun Han, Lu-Lu Xu, Tian-Qiao Song, Cai-Hong Yun, Xue Qiao, and Min YePNAS December 1, 2020 117 (48) 30816-30823; first published November 16, 2020. https://doi.org/10.1073/pnas.2012745117
Population Biology
- Open AccessNetwork interventions for managing the COVID-19 pandemic and sustaining economyAkihiro Nishi, George Dewey, Akira Endo, Sophia Neman, Sage K. Iwamoto, Michael Y. Ni, Yusuke Tsugawa, Georgios Iosifidis, Justin D. Smith, and Sean D. YoungPNAS December 1, 2020 117 (48) 30285-30294; first published November 11, 2020. https://doi.org/10.1073/pnas.2014297117
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- Considering network interventions- Dec 21, 2020
- You have accessGlobal associations between macronutrient supply and age-specific mortalityAlistair M. Senior, Shinichi Nakagawa, David Raubenheimer, and Stephen J. SimpsonPNAS December 1, 2020 117 (48) 30824-30835; first published November 16, 2020. https://doi.org/10.1073/pnas.2015058117
Psychological and Cognitive Sciences
- You have accessA source for awareness-dependent figure–ground segregation in human prefrontal cortexLing Huang, Lijuan Wang, Wangming Shen, Mengsha Li, Shiyu Wang, Xiaotong Wang, Leslie G. Ungerleider, and Xilin ZhangPNAS December 1, 2020 117 (48) 30836-30847; first published November 16, 2020. https://doi.org/10.1073/pnas.1922832117
Systems Biology
- You have accessMutation bias within oncogene families is related to proliferation-specific codon usageHannah Benisty, Marc Weber, Xavier Hernandez-Alias, Martin H. Schaefer, and Luis SerranoPNAS December 1, 2020 117 (48) 30848-30856; first published November 16, 2020. https://doi.org/10.1073/pnas.2016119117
Corrections
- You have accessCorrection for Li et al., Multiorbital charge-density wave excitations and concomitant phonon anomalies in Bi2Sr2LaCuO6+δPNAS December 1, 2020 117 (48) 30857; first published November 16, 2020. https://doi.org/10.1073/pnas.2022009117
- You have accessCorrection for Ahmad et al., Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small moleculePNAS December 1, 2020 117 (48) 30858; first published November 9, 2020. https://doi.org/10.1073/pnas.2021828117
- You have accessCorrection for Yaron et al., Forelimb force direction and magnitude independently controlled by spinal modules in the macaquePNAS December 1, 2020 117 (48) 30859; first published November 9, 2020. https://doi.org/10.1073/pnas.2022015117
SI Correction
- You have accessCorrection to Supporting Information for Morales-Castilla et al., Diversity buffers winegrowing regions from climate change lossesPNAS December 1, 2020 117 (48) 30860; first published November 9, 2020. https://doi.org/10.1073/pnas.2019721117
Commentaries
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