Does tocilizumab have a magical therapeutic effect on COVID-19 patients without obvious adverse reactions?
- aDepartment of Rheumatology, Southwest Hospital, Army Medical University (the Third Military Medical University), Chongqing 400038, People's Republic of China;
- bDepartment of Infection, Taikang Tongji COVID-19 Hospital, Wuhan 430000, People's Republic of China;
- cDepartment of Infection, Southwest Hospital, Army Medical University (the Third Military Medical University), Chongqing 400038, People's Republic of China;
- dDepartment of Infection, Huoshenshan COVID-19 Hospital, Wuhan 430000, People's Republic of China;
- eDepartment of Respiratory and Critical Care Medicine, Southwest Hospital, Army Medical University (the Third Military Medical University), Chongqing 400038, People's Republic of China
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Coronavirus disease 2019 (COVID-19) may cause a cytokine storm, which may lead to respiratory failure or even death, and the mortality rate for critically ill cases reached 60.5% (1, 2). In a retrospective observational study conducted by Xu et al. (3), all 21 patients, including 17 seriously ill and 4 critically ill cases (4), had been discharged after an average of 15.1 d, and no patient died after taking tocilizumab (TCZ). This indicates that TCZ has almost a magical therapeutic effect on COVID-19 patients. However, our findings are not optimistic. In Taikang Tongji Hospital, all 12 patients with elevated interleukin-6 (IL-6) levels, …
↵1To whom correspondence may be addressed. Email: xiangdongzhou{at}126.com or qingmao{at}tmmu.edu.cn.
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