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Letter

Does tocilizumab have a magical therapeutic effect on COVID-19 patients without obvious adverse reactions?

View ORCID ProfileYong Wang, View ORCID ProfileQing Mao, and View ORCID ProfileXiangdong Zhou
  1. aDepartment of Rheumatology, Southwest Hospital, Army Medical University (the Third Military Medical University), Chongqing 400038, People's Republic of China;
  2. bDepartment of Infection, Taikang Tongji COVID-19 Hospital, Wuhan 430000, People's Republic of China;
  3. cDepartment of Infection, Southwest Hospital, Army Medical University (the Third Military Medical University), Chongqing 400038, People's Republic of China;
  4. dDepartment of Infection, Huoshenshan COVID-19 Hospital, Wuhan 430000, People's Republic of China;
  5. eDepartment of Respiratory and Critical Care Medicine, Southwest Hospital, Army Medical University (the Third Military Medical University), Chongqing 400038, People's Republic of China

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PNAS December 8, 2020 117 (49) 30896-30897; first published November 17, 2020; https://doi.org/10.1073/pnas.2009961117
Yong Wang
aDepartment of Rheumatology, Southwest Hospital, Army Medical University (the Third Military Medical University), Chongqing 400038, People's Republic of China;
bDepartment of Infection, Taikang Tongji COVID-19 Hospital, Wuhan 430000, People's Republic of China;
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Qing Mao
cDepartment of Infection, Southwest Hospital, Army Medical University (the Third Military Medical University), Chongqing 400038, People's Republic of China;
dDepartment of Infection, Huoshenshan COVID-19 Hospital, Wuhan 430000, People's Republic of China;
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  • For correspondence: xiangdongzhou@126.com qingmao@tmmu.edu.cn
Xiangdong Zhou
bDepartment of Infection, Taikang Tongji COVID-19 Hospital, Wuhan 430000, People's Republic of China;
eDepartment of Respiratory and Critical Care Medicine, Southwest Hospital, Army Medical University (the Third Military Medical University), Chongqing 400038, People's Republic of China
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  • For correspondence: xiangdongzhou@126.com qingmao@tmmu.edu.cn
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Coronavirus disease 2019 (COVID-19) may cause a cytokine storm, which may lead to respiratory failure or even death, and the mortality rate for critically ill cases reached 60.5% (1, 2). In a retrospective observational study conducted by Xu et al. (3), all 21 patients, including 17 seriously ill and 4 critically ill cases (4), had been discharged after an average of 15.1 d, and no patient died after taking tocilizumab (TCZ). This indicates that TCZ has almost a magical therapeutic effect on COVID-19 patients. However, our findings are not optimistic. In Taikang Tongji Hospital, all 12 patients with elevated interleukin-6 (IL-6) levels, …

↵1To whom correspondence may be addressed. Email: xiangdongzhou{at}126.com or qingmao{at}tmmu.edu.cn.

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Does tocilizumab have a magical therapeutic effect on COVID-19 patients without obvious adverse reactions?
Yong Wang, Qing Mao, Xiangdong Zhou
Proceedings of the National Academy of Sciences Dec 2020, 117 (49) 30896-30897; DOI: 10.1073/pnas.2009961117

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Does tocilizumab have a magical therapeutic effect on COVID-19 patients without obvious adverse reactions?
Yong Wang, Qing Mao, Xiangdong Zhou
Proceedings of the National Academy of Sciences Dec 2020, 117 (49) 30896-30897; DOI: 10.1073/pnas.2009961117
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  • Biological Sciences
  • Immunology and Inflammation

This Letter has a Reply and related content. Please see:

  • Relationship between Letter and Reply - November 17, 2020
  • Effective treatment of severe COVID-19 patients with tocilizumab - April 29, 2020
Proceedings of the National Academy of Sciences: 117 (49)
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