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Research Article

Development and validation of a potent and specific inhibitor for the CLC-2 chloride channel

View ORCID ProfileAnna K. Koster, View ORCID ProfileAustin L. Reese, Yuri Kuryshev, Xianlan Wen, View ORCID ProfileKeri A. McKiernan, View ORCID ProfileErin E. Gray, Caiyun Wu, View ORCID ProfileJohn R. Huguenard, View ORCID ProfileMerritt Maduke, and View ORCID ProfileJ. Du Bois
  1. aDepartment of Chemistry, Stanford University, Stanford, CA 94305;
  2. bDepartment of Molecular & Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305;
  3. cDepartment of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305;
  4. dCharles River Laboratories Cleveland, Inc., Cleveland, OH 44128

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PNAS December 22, 2020 117 (51) 32711-32721; first published December 4, 2020; https://doi.org/10.1073/pnas.2009977117
Anna K. Koster
aDepartment of Chemistry, Stanford University, Stanford, CA 94305;
bDepartment of Molecular & Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305;
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  • ORCID record for Anna K. Koster
Austin L. Reese
cDepartment of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305;
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  • ORCID record for Austin L. Reese
Yuri Kuryshev
dCharles River Laboratories Cleveland, Inc., Cleveland, OH 44128
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Xianlan Wen
bDepartment of Molecular & Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305;
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Keri A. McKiernan
aDepartment of Chemistry, Stanford University, Stanford, CA 94305;
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Erin E. Gray
aDepartment of Chemistry, Stanford University, Stanford, CA 94305;
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Caiyun Wu
dCharles River Laboratories Cleveland, Inc., Cleveland, OH 44128
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John R. Huguenard
cDepartment of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305;
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  • ORCID record for John R. Huguenard
  • For correspondence: john.huguenard@stanford.edu maduke@stanford.edu jdubois@stanford.edu
Merritt Maduke
bDepartment of Molecular & Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305;
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  • For correspondence: john.huguenard@stanford.edu maduke@stanford.edu jdubois@stanford.edu
J. Du Bois
aDepartment of Chemistry, Stanford University, Stanford, CA 94305;
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  • For correspondence: john.huguenard@stanford.edu maduke@stanford.edu jdubois@stanford.edu
  1. Edited by Richard W. Aldrich, The University of Texas at Austin, Austin, TX, and approved October 22, 2020 (received for review May 21, 2020)

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Development and validation of a potent and specific inhibitor for the CLC-2 chloride channel
Anna K. Koster, Austin L. Reese, Yuri Kuryshev, Xianlan Wen, Keri A. McKiernan, Erin E. Gray, Caiyun Wu, John R. Huguenard, Merritt Maduke, J. Du Bois
Proceedings of the National Academy of Sciences Dec 2020, 117 (51) 32711-32721; DOI: 10.1073/pnas.2009977117

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Development and validation of a potent and specific inhibitor for the CLC-2 chloride channel
Anna K. Koster, Austin L. Reese, Yuri Kuryshev, Xianlan Wen, Keri A. McKiernan, Erin E. Gray, Caiyun Wu, John R. Huguenard, Merritt Maduke, J. Du Bois
Proceedings of the National Academy of Sciences Dec 2020, 117 (51) 32711-32721; DOI: 10.1073/pnas.2009977117
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Proceedings of the National Academy of Sciences: 117 (51)
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