QnAs with NAS member and bioengineer Sangeeta Bhatia.
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In Guglielmini et al. (1), we analyze the evolutionary relationships between Nucleo-Cytoplasmic Large DNA Viruses (NCLDVs) and the cellular domains based on the two largest universal markers, that is, the two largest RNA polymerase subunits (RNAP). We conclude that NCLDVs diversified before the emergence of the last eukaryotic common ancestor (LECA). Our results now draw criticism from Ku and Sun (2).
They notably describe as a flaw the three-domain (3d) topology displayed by our RNAP trees, exposing an unjustified prejudice in favor of the two-domain (2d) topology. Indeed, the debate between the 2d and 3d scenarios is still open, as exemplified by the still unsolved phylogenomic challenges and the recent robust multigene phylogenies …
↵1To whom correspondence may be addressed. Email: morgan.gaia{at}live.fr or patrick.forterre{at}pasteur.fr.
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Reply to Ku and Sun: Ancestors of modern giant and large eukaryotic dsDNA viruses infected proto-eukaryotes
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