Proceedings of the National Academy of Sciences: 117 (8)

New Research In

February 25, 2020; vol. 117 no. 8

This Week in PNAS

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In This Issue
PNAS February 25, 2020 117 (8) 3885-3887; https://doi.org/10.1073/iti0820117

Opinion

Leading scientists discuss current issues.

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Opinion: Sustainable development must account for pandemic risk
Front Matter
Moreno Di Marco, Michelle L. Baker, Peter Daszak, Paul De Barro, Evan A. Eskew, Cecile M. Godde, Tom D. Harwood, Mario Herrero, Andrew J. Hoskins, Erica Johnson, William B. Karesh, Catherine Machalaba, Javier Navarro Garcia, Dean Paini, Rebecca Pirzl, Mark Stafford Smith, Carlos Zambrana-Torrelio, and Simon Ferrier

PNAS February 25, 2020 117 (8) 3888-3892; first published February 14, 2020. https://doi.org/10.1073/pnas.2001655117

QnAs

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QnAs with Bin Yu
Farooq Ahmed

PNAS February 25, 2020 117 (8) 3893-3894; first published February 12, 2020. https://doi.org/10.1073/pnas.2001302117
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Veridical data science
- Feb 25, 2020

Commentaries

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Insight into the multifunctional RNA synthesis machine of rabies virus
Ervin Fodor

PNAS February 25, 2020 117 (8) 3895-3897; first published January 28, 2020. https://doi.org/10.1073/pnas.2000120117
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Structure of a rabies virus polymerase complex from electron cryo-microscopy
- Jan 28, 2020
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A Plasmodium key fits a mosquito lock
Sung-Jae Cha and Marcelo Jacobs-Lorena

PNAS February 25, 2020 117 (8) 3898-3900; first published February 5, 2020. https://doi.org/10.1073/pnas.2000122117
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Plasmodium falciparum evades immunity of anopheline mosquitoes by interacting with a Pfs47 midgut receptor
- Feb 04, 2020
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How the brain pays attention to others’ attention
David A. Leopold and Richard J. Krauzlis

PNAS February 25, 2020 117 (8) 3901-3903; first published February 6, 2020. https://doi.org/10.1073/pnas.2000121117
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Decoding of the other’s focus of attention by a temporal cortex module
- Feb 04, 2020
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Understanding the genetic architecture of human retinal degenerations
J. Fielding Hejtmancik and Stephen P. Daiger

PNAS February 25, 2020 117 (8) 3904-3906; first published February 7, 2020. https://doi.org/10.1073/pnas.1922925117
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Worldwide carrier frequency and genetic prevalence of autosomal recessive inherited retinal diseases
- Feb 04, 2020
Open Access
Frogs give new insights into vertebrate novelties
Marvalee H. Wake

PNAS February 25, 2020 117 (8) 3907-3909; first published February 5, 2020. https://doi.org/10.1073/pnas.1922922117
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Ontogeny of the anuran urostyle and the developmental context of evolutionary novelty
- Feb 11, 2020

Letters

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Antibiotic treatment and selection for glpK mutations in patients with active tuberculosis disease
Roger Vargas Jr and Maha R. Farhat

PNAS February 25, 2020 117 (8) 3910-3912; first published February 19, 2020. https://doi.org/10.1073/pnas.1920788117
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Reply to Vargas and Farhat: Mycobacterium tuberculosis glpK mutants in human tuberculosis
Hassan Safi, David R. Sherman, Thomas Dick, and David Alland

PNAS February 25, 2020 117 (8) 3913-3914; first published February 19, 2020. https://doi.org/10.1073/pnas.1922199117
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Phase variation in Mycobacterium tuberculosis glpK produces transiently heritable drug tolerance
- Sep 24, 2019
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Reduction in TOM1 expression exacerbates Alzheimer’s disease
Jiajie Peng and Tianyi Zhao

PNAS February 25, 2020 117 (8) 3915-3916; first published February 11, 2020. https://doi.org/10.1073/pnas.1917589117
Open Access
Reply to Peng and Zhao: Loss of endocytic protein TOM1 in Alzheimer’s disease
Alessandra C. Martini, David Baglietto-Vargas, Rodrigo Medeiros, and Frank M. LaFerla

PNAS February 25, 2020 117 (8) 3917-3919; first published February 11, 2020. https://doi.org/10.1073/pnas.1917743117
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Amyloid-beta impairs TOM1-mediated IL-1R1 signaling
- Oct 15, 2019

Physical Sciences

Applied Physical Sciences
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  Anharmonic lattice dynamics and superionic transition in AgCrSe₂
  Jingxuan Ding, Jennifer L. Niedziela, Dipanshu Bansal, Jiuling Wang, Xing He, Andrew F. May, Georg Ehlers, Douglas L. Abernathy, Ayman Said, Ahmet Alatas, Yang Ren, Gaurav Arya, and Olivier Delaire
  
  PNAS February 25, 2020 117 (8) 3930-3937; first published February 6, 2020. https://doi.org/10.1073/pnas.1913916117
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  Mesoscale structure of wrinkle patterns and defect-proliferated liquid crystalline phases
  Oleh Tovkach, Junbo Chen, Monica M. Ripp, Teng Zhang, Joseph D. Paulsen, and Benny Davidovitch
  
  PNAS February 25, 2020 117 (8) 3938-3943; first published February 11, 2020. https://doi.org/10.1073/pnas.1916221117
Biophysics and Computational Biology
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  Molecular underpinnings of cytoskeletal cross-talk
  Angela Oberhofer, Emanuel Reithmann, Peter Spieler, Willi L. Stepp, Dennis Zimmermann, Bettina Schmid, Erwin Frey, and Zeynep Ökten
  
  PNAS February 25, 2020 117 (8) 3944-3952; first published February 10, 2020. https://doi.org/10.1073/pnas.1917964117
- Open Access
  Mechanism for neurotransmitter-receptor matching
  Dena R. Hammond-Weinberger, Yunxin Wang, Alex Glavis-Bloom, and Nicholas C. Spitzer
  
  PNAS February 25, 2020 117 (8) 4368-4374; first published February 10, 2020. https://doi.org/10.1073/pnas.1916600117
Chemistry
- Open Access
  Opto-chemo-mechanical transduction in photoresponsive gels elicits switchable self-trapped beams with remote interactions
  Derek R. Morim, Amos Meeks, Ankita Shastri, Andy Tran, Anna V. Shneidman, Victor V. Yashin, Fariha Mahmood, Anna C. Balazs, Joanna Aizenberg, and Kalaichelvi Saravanamuttu
  
  PNAS February 25, 2020 117 (8) 3953-3959; first published February 6, 2020. https://doi.org/10.1073/pnas.1902872117
Earth, Atmospheric, and Planetary Sciences
- Open Access
  An unexpected catalyst dominates formation and radiative forcing of regional haze
  Fang Zhang, Yuan Wang, Jianfei Peng, Lu Chen, Yele Sun, Lian Duan, Xinlei Ge, Yixin Li, Jiayun Zhao, Chao Liu, Xiaochun Zhang, Gen Zhang, Yuepeng Pan, Yuesi Wang, Annie L. Zhang, Yuemeng Ji, Gehui Wang, Min Hu, Mario J. Molina, and Renyi Zhang
  
  PNAS February 25, 2020 117 (8) 3960-3966; first published February 10, 2020. https://doi.org/10.1073/pnas.1919343117
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  Early atmospheric contamination on the top of the Himalayas since the onset of the European Industrial Revolution
  From the Cover
  
  Paolo Gabrielli, Anna Wegner, M. Roxana Sierra-Hernández, Emilie Beaudon, Mary Davis, Joel D. Barker, and Lonnie G. Thompson
  
  PNAS February 25, 2020 117 (8) 3967-3973; first published February 10, 2020. https://doi.org/10.1073/pnas.1910485117
- Open Access
  Orbital pacing and secular evolution of the Early Jurassic carbon cycle
  Marisa S. Storm, Stephen P. Hesselbo, Hugh C. Jenkyns, Micha Ruhl, Clemens V. Ullmann, Weimu Xu, Melanie J. Leng, James B. Riding, and Olga Gorbanenko
  
  PNAS February 25, 2020 117 (8) 3974-3982; first published February 10, 2020. https://doi.org/10.1073/pnas.1912094117
- Open Access
  The typhoon-induced drying of the Maritime Continent
  Enrico Scoccimarro, Silvio Gualdi, Alessio Bellucci, Daniele Peano, Annalisa Cherchi, Gabriel A. Vecchi, and Antonio Navarra
  
  PNAS February 25, 2020 117 (8) 3983-3988; first published February 10, 2020. https://doi.org/10.1073/pnas.1915364117
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  Isotopic evidence for quasi-equilibrium chemistry in thermally mature natural gases
  Nivedita Thiagarajan, Hao Xie, Camilo Ponton, Nami Kitchen, Brian Peterson, Michael Lawson, Michael Formolo, Yitian Xiao, and John Eiler
  
  PNAS February 25, 2020 117 (8) 3989-3995; first published February 11, 2020. https://doi.org/10.1073/pnas.1906507117
- Open Access
  Early Last Interglacial ocean warming drove substantial ice mass loss from Antarctica
  Chris S. M. Turney, Christopher J. Fogwill, Nicholas R. Golledge, Nicholas P. McKay, Erik van Sebille, Richard T. Jones, David Etheridge, Mauro Rubino, David P. Thornton, Siwan M. Davies, Christopher Bronk Ramsey, Zoë A. Thomas, Michael I. Bird, Niels C. Munksgaard, Mika Kohno, John Woodward, Kate Winter, Laura S. Weyrich, Camilla M. Rootes, Helen Millman, Paul G. Albert, Andres Rivera, Tas van Ommen, Mark Curran, Andrew Moy, Stefan Rahmstorf, Kenji Kawamura, Claus-Dieter Hillenbrand, Michael E. Weber, Christina J. Manning, Jennifer Young, and Alan Cooper
  
  PNAS February 25, 2020 117 (8) 3996-4006; first published February 11, 2020. https://doi.org/10.1073/pnas.1902469117
Engineering
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  Short-wavelength optoacoustic spectroscopy based on water muting
  Jaya Prakash, Mir Mehdi Seyedebrahimi, Ara Ghazaryan, Jaber Malekzadeh-Najafabadi, Vipul Gujrati, and Vasilis Ntziachristos
  
  PNAS February 25, 2020 117 (8) 4007-4014; first published February 6, 2020. https://doi.org/10.1073/pnas.1910597117
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  Harnessing transition waves to realize deployable structures
  Ahmad Zareei, Bolei Deng, and Katia Bertoldi
  
  PNAS February 25, 2020 117 (8) 4015-4020; first published February 10, 2020. https://doi.org/10.1073/pnas.1917887117
- Open Access
  In situ genetic engineering of tumors for long-lasting and systemic immunotherapy
  Stephany Y. Tzeng, Kisha K. Patel, David R. Wilson, Randall A. Meyer, Kelly R. Rhodes, and Jordan J. Green
  
  PNAS February 25, 2020 117 (8) 4043-4052; first published February 7, 2020. https://doi.org/10.1073/pnas.1916039117
Physics
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  Inelastic neutron scattering evidence for anomalous H–H distances in metal hydrides
  Andreas Borgschulte, Jasmin Terreni, Emanuel Billeter, Luke Daemen, Yongqiang Cheng, Anup Pandey, Zbigniew Łodziana, Russell J. Hemley, and Anibal J. Ramirez-Cuesta
  
  PNAS February 25, 2020 117 (8) 4021-4026; first published February 6, 2020. https://doi.org/10.1073/pnas.1912900117
Statistics
- Open Access
  Veridical data science
  Inaugural Article
  
  Bin Yu and Karl Kumbier
  
  PNAS February 25, 2020 117 (8) 3920-3929; first published February 13, 2020. https://doi.org/10.1073/pnas.1901326117
  
  See companion article:
  QnAs with Bin Yu
  - Feb 25, 2020

Biological Sciences

Applied Biological Sciences
- Open Access
  In situ genetic engineering of tumors for long-lasting and systemic immunotherapy
  Stephany Y. Tzeng, Kisha K. Patel, David R. Wilson, Randall A. Meyer, Kelly R. Rhodes, and Jordan J. Green
  
  PNAS February 25, 2020 117 (8) 4043-4052; first published February 7, 2020. https://doi.org/10.1073/pnas.1916039117
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  The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning
  Peter M. Bruno, Mengrou Lu, Kady A. Dennis, Haider Inam, Connor J. Moore, John Sheehe, Stephen J. Elledge, Michael T. Hemann, and Justin R. Pritchard
  
  PNAS February 25, 2020 117 (8) 4053-4060; first published February 10, 2020. https://doi.org/10.1073/pnas.1921649117
Biochemistry
- Open Access
  Structural analysis of a trimeric assembly of the mitochondrial dynamin-like GTPase Mgm1
  Liming Yan, Yuanbo Qi, Derek Ricketson, Lei Li, Kelly Subramanian, Jinghua Zhao, Caiting Yu, Lijie Wu, Reta Sarsam, Melissa Wong, Zhiyong Lou, Zihe Rao, Jodi Nunnari, and Junjie Hu
  
  PNAS February 25, 2020 117 (8) 4061-4070; first published February 10, 2020. https://doi.org/10.1073/pnas.1919116117
- Open Access
  High-resolution neutron crystallography visualizes an OH-bound resting state of a copper-containing nitrite reductase
  Yohta Fukuda, Yu Hirano, Katsuhiro Kusaka, Tsuyoshi Inoue, and Taro Tamada
  
  PNAS February 25, 2020 117 (8) 4071-4077; first published February 10, 2020. https://doi.org/10.1073/pnas.1918125117
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  Erk1/2 inactivation promotes a rapid redistribution of COP1 and degradation of COP1 substrates
  Weiming Ouyang, Pengfei Guo, Kazuyo Takeda, Qiong Fu, Hui Fang, and David M. Frucht
  
  PNAS February 25, 2020 117 (8) 4078-4087; first published February 10, 2020. https://doi.org/10.1073/pnas.1913698117
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  Structural dynamics of the human COP9 signalosome revealed by cross-linking mass spectrometry and integrative modeling
  Craig Gutierrez, Ilan E. Chemmama, Haibin Mao, Clinton Yu, Ignacia Echeverria, Sarah A. Block, Scott D. Rychnovsky, Ning Zheng, Andrej Sali, and Lan Huang
  
  PNAS February 25, 2020 117 (8) 4088-4098; first published February 7, 2020. https://doi.org/10.1073/pnas.1915542117
- Open Access
  Role for ribosome-associated quality control in sampling proteins for MHC class I-mediated antigen presentation
  Débora Broch Trentini, Matteo Pecoraro, Shivani Tiwary, Jürgen Cox, Matthias Mann, Mark S. Hipp, and F. Ulrich Hartl
  
  PNAS February 25, 2020 117 (8) 4099-4108; first published February 11, 2020. https://doi.org/10.1073/pnas.1914401117
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  Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics
  Jae Cho, Minhee Lee, C. Skyler Cochrane, Caroline G. Webster, Benjamin A. Fenton, Jinshi Zhao, Jiyong Hong, and Pei Zhou
  
  PNAS February 25, 2020 117 (8) 4109-4116; first published February 10, 2020. https://doi.org/10.1073/pnas.1912876117
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  Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome
  Hong Lin, Xiaozhe Zhang, Li Liu, Qiuyu Fu, Chuanlong Zang, Yan Ding, Yang Su, Zhixue Xu, Sining He, Xiaoli Yang, Xiayun Wei, Haibin Mao, Yasong Cui, Yi Wei, Chuanzheng Zhou, Lilin Du, Niu Huang, Ning Zheng, Tao Wang, and Feng Rao
  
  PNAS February 25, 2020 117 (8) 4117-4124; first published February 11, 2020. https://doi.org/10.1073/pnas.1911998117
Biophysics and Computational Biology
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  Molecular underpinnings of cytoskeletal cross-talk
  Angela Oberhofer, Emanuel Reithmann, Peter Spieler, Willi L. Stepp, Dennis Zimmermann, Bettina Schmid, Erwin Frey, and Zeynep Ökten
  
  PNAS February 25, 2020 117 (8) 3944-3952; first published February 10, 2020. https://doi.org/10.1073/pnas.1917964117
- You have access
  Short-wavelength optoacoustic spectroscopy based on water muting
  Jaya Prakash, Mir Mehdi Seyedebrahimi, Ara Ghazaryan, Jaber Malekzadeh-Najafabadi, Vipul Gujrati, and Vasilis Ntziachristos
  
  PNAS February 25, 2020 117 (8) 4007-4014; first published February 6, 2020. https://doi.org/10.1073/pnas.1910597117
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  Exploring the interplay between fibrillization and amorphous aggregation channels on the energy landscapes of tau repeat isoforms
  Xun Chen, Mingchen Chen, Nicholas P. Schafer, and Peter G. Wolynes
  
  PNAS February 25, 2020 117 (8) 4125-4130; first published February 6, 2020. https://doi.org/10.1073/pnas.1921702117
- Open Access
  High-resolution structural insights into the heliorhodopsin family
  K. Kovalev, D. Volkov, R. Astashkin, A. Alekseev, I. Gushchin, J. M. Haro-Moreno, I. Chizhov, S. Siletsky, M. Mamedov, A. Rogachev, T. Balandin, V. Borshchevskiy, A. Popov, G. Bourenkov, E. Bamberg, F. Rodriguez-Valera, G. Büldt, and V. Gordeliy
  
  PNAS February 25, 2020 117 (8) 4131-4141; first published February 7, 2020. https://doi.org/10.1073/pnas.1915888117
- Open Access
  Radiation damage and dose limits in serial synchrotron crystallography at cryo- and room temperatures
  Eugenio de la Mora, Nicolas Coquelle, Charles S. Bury, Martin Rosenthal, James M. Holton, Ian Carmichael, Elspeth F. Garman, Manfred Burghammer, Jacques-Philippe Colletier, and Martin Weik
  
  PNAS February 25, 2020 117 (8) 4142-4151; first published February 11, 2020. https://doi.org/10.1073/pnas.1821522117
Cell Biology
- Open Access
  Loss of phenotypic inheritance associated with ydcI mutation leads to increased frequency of small, slow persisters in Escherichia coli
  Suzanne M. Hingley-Wilson, Nan Ma, Yin Hu, Rosalyn Casey, Anders Bramming, Richard J. Curry, Hongying Lilian Tang, Huihai Wu, Rachel E. Butler, William R. Jacobs Jr, Andrea Rocco, and Johnjoe McFadden
  
  PNAS February 25, 2020 117 (8) 4152-4157; first published February 6, 2020. https://doi.org/10.1073/pnas.1914741117
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  Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects
  Zhihua Jiao, Huaqing Cai, Yu Long, Orit Katarina Sirka, Veena Padmanaban, Andrew J. Ewald, and Peter N. Devreotes
  
  PNAS February 25, 2020 117 (8) 4158-4168; first published February 12, 2020. https://doi.org/10.1073/pnas.1917938117
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  Actin reduction by MsrB2 is a key component of the cytokinetic abscission checkpoint and prevents tetraploidy
  Jian Bai, Hugo Wioland, Tamara Advedissian, Frédérique Cuvelier, Guillaume Romet-Lemonne, and Arnaud Echard
  
  PNAS February 25, 2020 117 (8) 4169-4179; first published February 6, 2020. https://doi.org/10.1073/pnas.1911629117
- Open Access
  The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition
  Simone F. Glaser, Andreas W. Heumüller, Lukas Tombor, Patrick Hofmann, Marion Muhly-Reinholz, Ariane Fischer, Stefan Günther, Karoline E. Kokot, David Hassel, Sandeep Kumar, Hanjoong Jo, Reinier A. Boon, Wesley Abplanalp, David John, Jes-Niels Boeckel, and Stefanie Dimmeler
  
  PNAS February 25, 2020 117 (8) 4180-4187; first published February 7, 2020. https://doi.org/10.1073/pnas.1913481117
Developmental Biology
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  A chordate species lacking Nodal utilizes calcium oscillation and Bmp for left–right patterning
  Takeshi A. Onuma, Momoko Hayashi, Fuki Gyoja, Kanae Kishi, Kai Wang, and Hiroki Nishida
  
  PNAS February 25, 2020 117 (8) 4188-4198; first published February 6, 2020. https://doi.org/10.1073/pnas.1916858117
- Open Access
  Fbxo9 functions downstream of Sox10 to determine neuron-glial fate choice in the dorsal root ganglia through Neurog2 destabilization
  Jessica Aijia Liu, Andrew Tai, Jialin Hong, May Pui Lai Cheung, Mai Har Sham, Kathryn S. E. Cheah, Chi Wai Cheung, and Martin Cheung
  
  PNAS February 25, 2020 117 (8) 4199-4210; first published February 6, 2020. https://doi.org/10.1073/pnas.1916164117
Ecology
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  Recent responses to climate change reveal the drivers of species extinction and survival
  From the Cover
  
  Cristian Román-Palacios and John J. Wiens
  
  PNAS February 25, 2020 117 (8) 4211-4217; first published February 10, 2020. https://doi.org/10.1073/pnas.1913007117
- Open Access
  Global gene flow releases invasive plants from environmental constraints on genetic diversity
  Annabel L. Smith, Trevor R. Hodkinson, Jesus Villellas, Jane A. Catford, Anna Mária Csergő, Simone P. Blomberg, Elizabeth E. Crone, Johan Ehrlén, Maria B. Garcia, Anna-Liisa Laine, Deborah A. Roach, Roberto Salguero-Gómez, Glenda M. Wardle, Dylan Z. Childs, Bret D. Elderd, Alain Finn, Sergi Munné-Bosch, Maude E. A. Baudraz, Judit Bódis, Francis Q. Brearley, Anna Bucharova, Christina M. Caruso, Richard P. Duncan, John M. Dwyer, Ben Gooden, Ronny Groenteman, Liv Norunn Hamre, Aveliina Helm, Ruth Kelly, Lauri Laanisto, Michele Lonati, Joslin L. Moore, Melanie Morales, Siri Lie Olsen, Meelis Pärtel, William K. Petry, Satu Ramula, Pil U. Rasmussen, Simone Ravetto Enri, Anna Roeder, Christiane Roscher, Marjo Saastamoinen, Ayco J. M. Tack, Joachim Paul Töpper, Gregory E. Vose, Elizabeth M. Wandrag, Astrid Wingler, and Yvonne M. Buckley
  
  PNAS February 25, 2020 117 (8) 4218-4227; first published February 7, 2020. https://doi.org/10.1073/pnas.1915848117
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  Urban warming advances spring phenology but reduces the response of phenology to temperature in the conterminous United States
  Lin Meng, Jiafu Mao, Yuyu Zhou, Andrew D. Richardson, Xuhui Lee, Peter E. Thornton, Daniel M. Ricciuto, Xuecao Li, Yongjiu Dai, Xiaoying Shi, and Gensuo Jia
  
  PNAS February 25, 2020 117 (8) 4228-4233; first published February 10, 2020. https://doi.org/10.1073/pnas.1911117117
Evolution
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  Continual evolution through coupled fast and slow feedbacks
  Meike T. Wortel, Han Peters, Juan A. Bonachela, and Nils Chr. Stenseth
  
  PNAS February 25, 2020 117 (8) 4234-4242; first published February 6, 2020. https://doi.org/10.1073/pnas.1916345117
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  Genomics of sorghum local adaptation to a parasitic plant
  From the Cover
  
  Emily S. Bellis, Elizabeth A. Kelly, Claire M. Lorts, Huirong Gao, Victoria L. DeLeo, Germinal Rouhan, Andrew Budden, Govinal B. Bhaskara, Zhenbin Hu, Robert Muscarella, Michael P. Timko, Baloua Nebie, Steven M. Runo, N. Doane Chilcoat, Thomas E. Juenger, Geoffrey P. Morris, Claude W. dePamphilis, and Jesse R. Lasky
  
  PNAS February 25, 2020 117 (8) 4243-4251; first published February 11, 2020. https://doi.org/10.1073/pnas.1908707117
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  A hemipteran insect reveals new genetic mechanisms and evolutionary insights into tracheal system development
  Lisa Hanna and Aleksandar Popadić
  
  PNAS February 25, 2020 117 (8) 4252-4261; first published February 10, 2020. https://doi.org/10.1073/pnas.1908975117
Genetics
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  Widespread organ tolerance to Xist loss and X reactivation except under chronic stress in the gut
  Lin Yang, Eda Yildirim, James E. Kirby, William Press, and Jeannie T. Lee
  
  PNAS February 25, 2020 117 (8) 4262-4272; first published February 10, 2020. https://doi.org/10.1073/pnas.1917203117
- Open Access
  Coalescence modeling of intrainfection Bacillus anthracis populations allows estimation of infection parameters in wild populations
  From the Cover
  
  W. Ryan Easterday, José Miguel Ponciano, Juan Pablo Gomez, Matthew N. Van Ert, Ted Hadfield, Karoun Bagamian, Jason K. Blackburn, Nils Chr. Stenseth, and Wendy C. Turner
  
  PNAS February 25, 2020 117 (8) 4273-4280; first published February 13, 2020. https://doi.org/10.1073/pnas.1920790117
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  Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination
  Su Jin Ham, Daewon Lee, Heesuk Yoo, Kyoungho Jun, Heejin Shin, and Jongkyeong Chung
  
  PNAS February 25, 2020 117 (8) 4281-4291; first published February 11, 2020. https://doi.org/10.1073/pnas.1909814117
Immunology and Inflammation
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  PD-1+ stemlike CD8 T cells are resident in lymphoid tissues during persistent LCMV infection
  Se Jin Im, Bogumila T Konieczny, William H. Hudson, David Masopust, and Rafi Ahmed
  
  PNAS February 25, 2020 117 (8) 4292-4299; first published February 7, 2020. https://doi.org/10.1073/pnas.1917298117
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  Nucleolar localization of RAG1 modulates V(D)J recombination activity
  Ryan M. Brecht, Catherine C. Liu, Helen A. Beilinson, Alexandra Khitun, Sarah A. Slavoff, and David G. Schatz
  
  PNAS February 25, 2020 117 (8) 4300-4309; first published February 11, 2020. https://doi.org/10.1073/pnas.1920021117
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  Centrioles control the capacity, but not the specificity, of cytotoxic T cell killing
  Fella Tamzalit, Diana Tran, Weiyang Jin, Vitaly Boyko, Hisham Bazzi, Ariella Kepecs, Lance C. Kam, Kathryn V. Anderson, and Morgan Huse
  
  PNAS February 25, 2020 117 (8) 4310-4319; first published February 10, 2020. https://doi.org/10.1073/pnas.1913220117
- Open Access
  IGLV3-21*01 is an inherited risk factor for CLL through the acquisition of a single-point mutation enabling autonomous BCR signaling
  Palash C. Maity, Mayas Bilal, Marvyn T. Koning, Marc Young, Cornelis A. M. van Bergen, Valerio Renna, Antonella Nicolò, Moumita Datta, Eva Gentner-Göbel, Rob S. Barendse, Sebastiaan F. Somers, Ruben A. L. de Groen, Joost S. P. Vermaat, Daniela Steinbrecher, Christof Schneider, Eugen Tausch, Tamara Bittolo, Riccardo Bomben, Andrea Nicola Mazzarello, Giovanni del Poeta, Wilma G. M. Kroes, J. Tom van Wezel, Katharina Imkeller, Christian E. Busse, Massimo Degano, Tamam Bakchoul, Axel Ronald Schulz, Henrik Mei, Paolo Ghia, Konstantia Kotta, Kostas Stamatopoulos, Hedda Wardemann, Antonella Zucchetto, Nicholas Chiorazzi, Valter Gattei, Stephan Stilgenbauer, Hendrik Veelken, and Hassan Jumaa
  
  PNAS February 25, 2020 117 (8) 4320-4327; first published February 11, 2020. https://doi.org/10.1073/pnas.1913810117
Medical Sciences
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  Impaired lipid metabolism by age-dependent DNA methylation alterations accelerates aging
  Xin Li, Jiaqiang Wang, Leyun Wang, Guihai Feng, Gen Li, Meixin Yu, Yufei Li, Chao Liu, Xuewei Yuan, Guangxi Zang, Zhihuan Li, Ling Zhao, Hong Ouyang, Qingli Quan, Guangyu Wang, Charlotte Zhang, Oulan Li, Junkai Xiang, Jian-Kang Zhu, Wei Li, Qi Zhou, and Kang Zhang
  
  PNAS February 25, 2020 117 (8) 4328-4336; first published February 6, 2020. https://doi.org/10.1073/pnas.1919403117
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  Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism
  Kristian K. Kristensen, Katrine Zinck Leth-Espensen, Haydyn D. T. Mertens, Gabriel Birrane, Muthuraman Meiyappan, Gunilla Olivecrona, Thomas J. D. Jørgensen, Stephen G. Young, and Michael Ploug
  
  PNAS February 25, 2020 117 (8) 4337-4346; first published February 7, 2020. https://doi.org/10.1073/pnas.1920202117
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  miR-196b-5p–mediated downregulation of TSPAN12 and GATA6 promotes tumor progression in non-small cell lung cancer
  Guang Liang, Wei Meng, Xiangjie Huang, Wangyu Zhu, Changtian Yin, Canwei Wang, Matteo Fassan, Yun Yu, Masahisa Kudo, Sisi Xiao, Chengguang Zhao, Peng Zou, Yumin Wang, Xiaokun Li, Carlo M. Croce, and Ri Cui
  
  PNAS February 25, 2020 117 (8) 4347-4357; first published February 10, 2020. https://doi.org/10.1073/pnas.1917531117
Microbiology
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  Heat-shock proteases promote survival of Pseudomonas aeruginosa during growth arrest
  David W. Basta, David Angeles-Albores, Melanie A. Spero, John A. Ciemniecki, and Dianne K. Newman
  
  PNAS February 25, 2020 117 (8) 4358-4367; first published February 6, 2020. https://doi.org/10.1073/pnas.1912082117
Neuroscience
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  Mechanism for neurotransmitter-receptor matching
  Dena R. Hammond-Weinberger, Yunxin Wang, Alex Glavis-Bloom, and Nicholas C. Spitzer
  
  PNAS February 25, 2020 117 (8) 4368-4374; first published February 10, 2020. https://doi.org/10.1073/pnas.1916600117
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  Connect-seq to superimpose molecular on anatomical neural circuit maps
  Naresh K. Hanchate, Eun Jeong Lee, Andria Ellis, Kunio Kondoh, Donghui Kuang, Ryan Basom, Cole Trapnell, and Linda B. Buck
  
  PNAS February 25, 2020 117 (8) 4375-4384; first published February 7, 2020. https://doi.org/10.1073/pnas.1912176117
- Open Access
  Brain and behavioral alterations in subjects with social anxiety dominated by empathic embarrassment
  Shisei Tei, Jukka-Pekka Kauppi, Kathryn F. Jankowski, Junya Fujino, Ricardo P. Monti, Jussi Tohka, Nobuhito Abe, Toshiya Murai, Hidehiko Takahashi, and Riitta Hari
  
  PNAS February 25, 2020 117 (8) 4385-4391; first published February 10, 2020. https://doi.org/10.1073/pnas.1918081117
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  Synaptotagmin-7 is a key factor for bipolar-like behavioral abnormalities in mice
  Wei Shen, Qiu-Wen Wang, Yao-Nan Liu, Maria C. Marchetto, Sara Linker, Si-Yao Lu, Yun Chen, Chuihong Liu, Chongye Guo, Zhikai Xing, Wei Shi, John R. Kelsoe, Martin Alda, Hongwei Wang, Yi Zhong, Sen-Fang Sui, Mei Zhao, Yiming Yang, Shuangli Mi, Liping Cao, Fred H. Gage, and Jun Yao
  
  PNAS February 25, 2020 117 (8) 4392-4399; first published February 10, 2020. https://doi.org/10.1073/pnas.1918165117
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  Multistep peripherin-2/rds self-assembly drives membrane curvature for outer segment disk architecture and photoreceptor viability
  Michelle L. Milstein, Breyanna L. Cavanaugh, Nicole M. Roussey, Stefanie Volland, David S. Williams, and Andrew F. X. Goldberg
  
  PNAS February 25, 2020 117 (8) 4400-4410; first published February 10, 2020. https://doi.org/10.1073/pnas.1912513117
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  Lack of RAN-mediated toxicity in Huntington’s disease knock-in mice
  Su Yang, Huiming Yang, Luoxiu Huang, Luxiao Chen, Zhaohui Qin, Shihua Li, and Xiao-Jiang Li
  
  PNAS February 25, 2020 117 (8) 4411-4417; first published February 6, 2020. https://doi.org/10.1073/pnas.1919197117
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  Sulfhydration of AKT triggers Tau-phosphorylation by activating glycogen synthase kinase 3β in Alzheimer’s disease
  Tanusree Sen, Pampa Saha, Tong Jiang, and Nilkantha Sen
  
  PNAS February 25, 2020 117 (8) 4418-4427; first published February 12, 2020. https://doi.org/10.1073/pnas.1916895117

Corrections

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Correction for Wang et al., Uncovering the functional residues of Arabidopsis isoprenoid biosynthesis enzyme HDS
PNAS February 25, 2020 117 (8) 4428; first published February 18, 2020. https://doi.org/10.1073/pnas.2001440117
You have access
Correction for Heng et al., BBX4, a phyB-interacting and modulated regulator, directly interacts with PIF3 to fine tune red light-mediated photomorphogenesis
PNAS February 25, 2020 117 (8) 4429-4430; first published February 18, 2020. https://doi.org/10.1073/pnas.2001373117

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