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Targeting RNA polymerase II Mediator subunits in cancer therapy

Targeting Transcription Factors in Cancer
Human cancers undergo an extremely diverse range of DNA mutations and rearrangements to generate oncogenes and to inactivate tumor suppressors in the process of their malignant transformation. As a consequence, decades of research have focused on the genes and the molecular pathways as well as the mechanisms that promote the growth of specific tumor cell types. This in turn has motivated the discovery and development of precision drugs that can target tumor-specific mechanisms. Although notable successes have been achieved, particularly with the targeting of oncogenes that encode protein kinases, many known drivers of human cancers have remained hitherto “undruggable” (1). These include unmutated transcription factors (TFs) such as Myc, Myb, E2F, and nuclear factor κB or chimeric transcriptional regulators generated by chromosomal translocations and novel gene fusions such as those encoding E2A-PBX1 and E2A-HLF. The DNA-binding domains of such oncogenic TFs, which confer specificity to their genomic actions, have proven to be intractable surfaces for selective and potent small molecules that can be developed into drugs.
The Roeder laboratory, along with other groups, has been analyzing the molecular properties and functions of the E2A-PBX1 fusion protein given its import as an oncogenic driver in 5 to 7% of pediatric acute lymphoblastic leukemias (ALLs). The chimeric protein is generated by the t(1;19)(q23;p13) chromosomal translocation and contains the DNA-binding domain (homeobox) of PBX1 and the transcriptional activation domains of E2A (2). In PNAS, Li et al. (3) provide deeper molecular insight into the mechanism by which E2A-PBX1 promotes dysregulated expression of a set of target genes, including an E2F family …
↵1Email: harinder{at}pitt.edu.
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