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Table of Contents

April 06, 2021; vol. 118 no. 14

This Week in PNAS

This week's research highlights
  • You have access
    In This Issue
    PNAS April 6, 2021 118 (14) eiti1421118; https://doi.org/10.1073/iti1421118

Core Concepts

A brief introduction to emerging topics in science
  • You have access
    Core Concept: Muography offers a new way to see inside a multitude of objects
    • Front Matter
    David Adam
    PNAS April 6, 2021 118 (14) e2104652118; https://doi.org/10.1073/pnas.2104652118

Retrospective

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    Alexander Spirin (1931–2020): A visionary scientist, a teacher, a colleague, a friend
    Valentina Evdokimova, Yuri Svitkin, and Nahum Sonenberg
    PNAS April 6, 2021 118 (14) e2103938118; https://doi.org/10.1073/pnas.2103938118

Commentaries

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    A slime mold’s remembrance of things past
    Robert H. Austin
    PNAS April 6, 2021 118 (14) e2102056118; https://doi.org/10.1073/pnas.2102056118

    See companion article:

    • Encoding memory in tube diameter hierarchy of living flow network
      - Feb 22, 2021
  • You have access
    Metabolic plasticity allows cancer cells to thrive under nutrient starvation
    Wilhelm Palm
    PNAS April 6, 2021 118 (14) e2102057118; https://doi.org/10.1073/pnas.2102057118

    See companion article:

    • Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1
      - Mar 02, 2021
  • Open Access
    Why does passion matter more in individualistic cultures?
    Jeanne L. Tsai
    PNAS April 6, 2021 118 (14) e2102055118; https://doi.org/10.1073/pnas.2102055118

    See companion article:

    • Passion matters but not equally everywhere: Predicting achievement from interest, enjoyment, and efficacy in 59 societies
      - Mar 12, 2021

Perspective

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    Climate change and state evolution
    Giacomo Benati and Carmine Guerriero
    PNAS April 6, 2021 118 (14) e2020893118; https://doi.org/10.1073/pnas.2020893118

Letters

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    No evidence that collective-good appeals best promote COVID-related health behaviors
    Nathaniel Rabb, David Glick, Attiyya Houston, Jake Bowers, and David Yokum
    PNAS April 6, 2021 118 (14) e2100662118; https://doi.org/10.1073/pnas.2100662118
  • You have access
    Reply to Rabb et al.: Why promoting COVID-19 vaccines with community immunity is not a good strategy (yet)
    Lars Korn, Robert Böhm, and Cornelia Betsch
    PNAS April 6, 2021 118 (14) e2102054118; https://doi.org/10.1073/pnas.2102054118

    See companion article:

    • Vaccination as a social contract
      - Jun 15, 2020

Brief Reports

  • Open Access
    Task-specific information outperforms surveillance-style big data in predictive analytics
    Andreas Bjerre-Nielsen, Valentin Kassarnig, David Dreyer Lassen, and Sune Lehmann
    PNAS April 6, 2021 118 (14) e2020258118; https://doi.org/10.1073/pnas.2020258118
  • Open Access
    Deep genetic affinity between coastal Pacific and Amazonian natives evidenced by Australasian ancestry
    Marcos Araújo Castro e Silva, Tiago Ferraz, Maria Cátira Bortolini, David Comas, and Tábita Hünemeier
    PNAS April 6, 2021 118 (14) e2025739118; https://doi.org/10.1073/pnas.2025739118

Physical Sciences

  • Applied Physical Sciences

    • Open Access
      Deep generative selection models of T and B cell receptor repertoires with soNNia
      Giulio Isacchini, Aleksandra M. Walczak, Thierry Mora, and Armita Nourmohammad
      PNAS April 6, 2021 118 (14) e2023141118; https://doi.org/10.1073/pnas.2023141118
    • You have access
      Molecular mechanism of abnormally large nonsoftening deformation in a tough hydrogel
      Ya Nan Ye, Kunpeng Cui, Wei Hong, Xueyu Li, Chengtao Yu, Dominique Hourdet, Tasuku Nakajima, Takayuki Kurokawa, and Jian Ping Gong
      PNAS April 6, 2021 118 (14) e2014694118; https://doi.org/10.1073/pnas.2014694118
    • You have access
      Vapor condensation with daytime radiative cooling
      Ming Zhou, Haomin Song, Xingyu Xu, Alireza Shahsafi, Yurui Qu, Zhenyang Xia, Zhenqiang Ma, Mikhail A. Kats, Jia Zhu, Boon S. Ooi, Qiaoqiang Gan, and Zongfu Yu
      PNAS April 6, 2021 118 (14) e2019292118; https://doi.org/10.1073/pnas.2019292118
    • You have access
      Tuning interactions between spins in a superconductor
      Hao Ding, Yuwen Hu, Mallika T. Randeria, Silas Hoffman, Oindrila Deb, Jelena Klinovaja, Daniel Loss, and Ali Yazdani
      PNAS April 6, 2021 118 (14) e2024837118; https://doi.org/10.1073/pnas.2024837118
    • Open Access
      Hidden order and multipolar exchange striction in a correlated f-electron system
      Leonid V. Pourovskii and Sergii Khmelevskyi
      PNAS April 6, 2021 118 (14) e2025317118; https://doi.org/10.1073/pnas.2025317118
  • Biophysics and Computational Biology

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      Interplays of electron and nuclear motions along CO dissociation trajectory in myoglobin revealed by ultrafast X-rays and quantum dynamics calculations
      Megan L. Shelby, Andrew Wildman, Dugan Hayes, Michael W. Mara, Patrick J. Lestrange, Marco Cammarata, Lodovico Balducci, Maxim Artamonov, Henrik T. Lemke, Diling Zhu, Tamar Seideman, Brian M. Hoffman, Xiaosong Li, and Lin X. Chen
      PNAS April 6, 2021 118 (14) e2018966118; https://doi.org/10.1073/pnas.2018966118
    • Open Access
      Overdispersion in COVID-19 increases the effectiveness of limiting nonrepetitive contacts for transmission control
      Kim Sneppen, Bjarke Frost Nielsen, Robert J. Taylor, and Lone Simonsen
      PNAS April 6, 2021 118 (14) e2016623118; https://doi.org/10.1073/pnas.2016623118
  • Chemistry

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      In situ small-angle X-ray scattering reveals solution phase discharge of Li–O2 batteries with weakly solvating electrolytes
      Christian Prehal, Aleksej Samojlov, Manfred Nachtnebel, Ludek Lovicar, Manfred Kriechbaum, Heinz Amenitsch, and Stefan A. Freunberger
      PNAS April 6, 2021 118 (14) e2021893118; https://doi.org/10.1073/pnas.2021893118
    • Open Access
      Turn-on mode diarylethenes for bioconjugation and fluorescence microscopy of cellular structures
      Kakishi Uno, Ayse Aktalay, Mariano L. Bossi, Masahiro Irie, Vladimir N. Belov, and Stefan W. Hell
      PNAS April 6, 2021 118 (14) e2100165118; https://doi.org/10.1073/pnas.2100165118
  • Earth, Atmospheric, and Planetary Sciences

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      Reconciling early Deccan Traps CO2 outgassing and pre-KPB global climate
      Andres Hernandez Nava, Benjamin A. Black, Sally A. Gibson, Robert J. Bodnar, Paul R. Renne, and Loÿc Vanderkluysen
      PNAS April 6, 2021 118 (14) e2007797118; https://doi.org/10.1073/pnas.2007797118
    • Open Access
      Supercell tornadoes are much stronger and wider than damage-based ratings indicate
      • From the Cover
      Joshua Wurman, Karen Kosiba, Trevor White, and Paul Robinson
      PNAS April 6, 2021 118 (14) e2021535118; https://doi.org/10.1073/pnas.2021535118
    • You have access
      Fluid-like elastic response of superionic NH3 in Uranus and Neptune
      Tomoaki Kimura and Motohiko Murakami
      PNAS April 6, 2021 118 (14) e2021810118; https://doi.org/10.1073/pnas.2021810118
  • Engineering

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      Imaging in vivo acetylcholine release in the peripheral nervous system with a fluorescent nanosensor
      Junfei Xia, Hongrong Yang, Michelle Mu, Nicholas Micovic, Kira E. Poskanzer, James R. Monaghan, and Heather A. Clark
      PNAS April 6, 2021 118 (14) e2023807118; https://doi.org/10.1073/pnas.2023807118
    • You have access
      Invariant plastic deformation mechanism in paramagnetic nickel–iron alloys
      Zhihua Dong, Wei Li, Stephan Schönecker, Bin Jiang, and Levente Vitos
      PNAS April 6, 2021 118 (14) e2023181118; https://doi.org/10.1073/pnas.2023181118
  • Environmental Sciences

    • Open Access
      Public data from three US states provide new insights into well integrity
      • From the Cover
      Greg Lackey, Harihar Rajaram, James Bolander, Owen A. Sherwood, Joseph N. Ryan, Chung Yan Shih, Grant S. Bromhal, and Robert M. Dilmore
      PNAS April 6, 2021 118 (14) e2013894118; https://doi.org/10.1073/pnas.2013894118
  • Physics

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      Self-shaping liquid crystal droplets by balancing bulk elasticity and interfacial tension
      Karthik Peddireddy, Simon Čopar, Khoa V. Le, Igor Muševič, Christian Bahr, and Venkata. S. R. Jampani
      PNAS April 6, 2021 118 (14) e2011174118; https://doi.org/10.1073/pnas.2011174118
    • You have access
      “Extraordinary” modulation instability in optics and hydrodynamics
      Guillaume Vanderhaegen, Corentin Naveau, Pascal Szriftgiser, Alexandre Kudlinski, Matteo Conforti, Arnaud Mussot, Miguel Onorato, Stefano Trillo, Amin Chabchoub, and Nail Akhmediev
      PNAS April 6, 2021 118 (14) e2019348118; https://doi.org/10.1073/pnas.2019348118
    • You have access
      A jamming plane of sphere packings
      Yuliang Jin and Hajime Yoshino
      PNAS April 6, 2021 118 (14) e2021794118; https://doi.org/10.1073/pnas.2021794118
    • You have access
      Structural relaxation and crystallization in supercooled water from 170 to 260 K
      Loni Kringle, Wyatt A. Thornley, Bruce D. Kay, and Greg A. Kimmel
      PNAS April 6, 2021 118 (14) e2022884118; https://doi.org/10.1073/pnas.2022884118
    • Open Access
      Van der Waals interaction affects wrinkle formation in two-dimensional materials
      Pablo Ares, Yi Bo Wang, Colin R. Woods, James Dougherty, Laura Fumagalli, Francisco Guinea, Benny Davidovitch, and Kostya S. Novoselov
      PNAS April 6, 2021 118 (14) e2025870118; https://doi.org/10.1073/pnas.2025870118
  • Sustainability Science

    • Open Access
      A coupled human–natural system analysis of freshwater security under climate and population change
      Jim Yoon, Christian Klassert, Philip Selby, Thibaut Lachaut, Stephen Knox, Nicolas Avisse, Julien Harou, Amaury Tilmant, Bernd Klauer, Daanish Mustafa, Katja Sigel, Samer Talozi, Erik Gawel, Josue Medellín-Azuara, Bushra Bataineh, Hua Zhang, and Steven M. Gorelick
      PNAS April 6, 2021 118 (14) e2020431118; https://doi.org/10.1073/pnas.2020431118

Social Sciences

  • Economic Sciences

    • Open Access
      Twenty-year economic impacts of deworming
      Joan Hamory, Edward Miguel, Michael Walker, Michael Kremer, and Sarah Baird
      PNAS April 6, 2021 118 (14) e2023185118; https://doi.org/10.1073/pnas.2023185118
  • Environmental Sciences

    • Open Access
      A coupled human–natural system analysis of freshwater security under climate and population change
      Jim Yoon, Christian Klassert, Philip Selby, Thibaut Lachaut, Stephen Knox, Nicolas Avisse, Julien Harou, Amaury Tilmant, Bernd Klauer, Daanish Mustafa, Katja Sigel, Samer Talozi, Erik Gawel, Josue Medellín-Azuara, Bushra Bataineh, Hua Zhang, and Steven M. Gorelick
      PNAS April 6, 2021 118 (14) e2020431118; https://doi.org/10.1073/pnas.2020431118
    • Open Access
      A synthesis of health benefits of natural sounds and their distribution in national parks
      • From the Cover
      Rachel T. Buxton, Amber L. Pearson, Claudia Allou, Kurt Fristrup, and George Wittemyer
      PNAS April 6, 2021 118 (14) e2013097118; https://doi.org/10.1073/pnas.2013097118
  • Political Sciences

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      Diversity in health care institutions reduces Israeli patients’ prejudice toward Arabs
      Chagai M. Weiss
      PNAS April 6, 2021 118 (14) e2022634118; https://doi.org/10.1073/pnas.2022634118
    • You have access
      Using random assignment to measure court accessibility for low-income divorce seekers
      D. James Greiner, Ellen Lee Degnan, Thomas Ferriss, and Roseanna Sommers
      PNAS April 6, 2021 118 (14) e2009086118; https://doi.org/10.1073/pnas.2009086118
    • Open Access
      The consequences of online partisan media
      Andrew M. Guess, Pablo Barberá, Simon Munzert, and JungHwan Yang
      PNAS April 6, 2021 118 (14) e2013464118; https://doi.org/10.1073/pnas.2013464118
  • Psychological and Cognitive Sciences

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      Ideology selectively shapes attention to inequality
      Hannah B. Waldfogel, Jennifer Sheehy-Skeffington, Oliver P. Hauser, Arnold K. Ho, and Nour S. Kteily
      PNAS April 6, 2021 118 (14) e2023985118; https://doi.org/10.1073/pnas.2023985118
    • Open Access
      A scalable empathic supervision intervention to mitigate recidivism from probation and parole
      Jason A. Okonofua, Kimia Saadatian, Joseph Ocampo, Michael Ruiz, and Perfecta Delgado Oxholm
      PNAS April 6, 2021 118 (14) e2018036118; https://doi.org/10.1073/pnas.2018036118
    • You have access
      Associations between adolescent cannabis use and young-adult functioning in three longitudinal twin studies
      Jonathan D. Schaefer, Nayla R. Hamdi, Stephen M. Malone, Scott Vrieze, Sylia Wilson, Matt McGue, and William G. Iacono
      PNAS April 6, 2021 118 (14) e2013180118; https://doi.org/10.1073/pnas.2013180118
    • You have access
      Cortical ensembles selective for context
      Jordan P. Hamm, Yuriy Shymkiv, Shuting Han, Weijian Yang, and Rafael Yuste
      PNAS April 6, 2021 118 (14) e2026179118; https://doi.org/10.1073/pnas.2026179118
    • Open Access
      Synchronous caregiving from birth to adulthood tunes humans’ social brain
      Adi Ulmer Yaniv, Roy Salomon, Shani Waidergoren, Ortal Shimon-Raz, Amir Djalovski, and Ruth Feldman
      PNAS April 6, 2021 118 (14) e2012900118; https://doi.org/10.1073/pnas.2012900118
  • Sustainability Science

    • Open Access
      The producer benefits of implicit fossil fuel subsidies in the United States
      Matthew J. Kotchen
      PNAS April 6, 2021 118 (14) e2011969118; https://doi.org/10.1073/pnas.2011969118

Biological Sciences

  • Applied Biological Sciences

    • You have access
      Imaging in vivo acetylcholine release in the peripheral nervous system with a fluorescent nanosensor
      Junfei Xia, Hongrong Yang, Michelle Mu, Nicholas Micovic, Kira E. Poskanzer, James R. Monaghan, and Heather A. Clark
      PNAS April 6, 2021 118 (14) e2023807118; https://doi.org/10.1073/pnas.2023807118
  • Biochemistry

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      Structural analyses of an RNA stability element interacting with poly(A)
      Seyed-Fakhreddin Torabi, Yen-Lin Chen, Kaiming Zhang, Jimin Wang, Suzanne J. DeGregorio, Anand T. Vaidya, Zhaoming Su, Suzette A. Pabit, Wah Chiu, Lois Pollack, and Joan A. Steitz
      PNAS April 6, 2021 118 (14) e2026656118; https://doi.org/10.1073/pnas.2026656118
    • Open Access
      Structure of Gcn1 bound to stalled and colliding 80S ribosomes
      Agnieszka A. Pochopien, Bertrand Beckert, Sergo Kasvandik, Otto Berninghausen, Roland Beckmann, Tanel Tenson, and Daniel N. Wilson
      PNAS April 6, 2021 118 (14) e2022756118; https://doi.org/10.1073/pnas.2022756118
    • You have access
      CLK1 reorganizes the splicing factor U1-70K for early spliceosomal protein assembly
      Brandon E. Aubol, Jacob M. Wozniak, Laurent Fattet, David J. Gonzalez, and Joseph A. Adams
      PNAS April 6, 2021 118 (14) e2018251118; https://doi.org/10.1073/pnas.2018251118
    • Open Access
      Substrate discrimination and quality control require each catalytic activity of TRAMP and the nuclear RNA exosome
      Mom Das, Dimitrios Zattas, John C. Zinder, Elizabeth V. Wasmuth, Julien Henri, and Christopher D. Lima
      PNAS April 6, 2021 118 (14) e2024846118; https://doi.org/10.1073/pnas.2024846118
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      The crystal structure of a 250-kDa heterotetrameric particle explains inhibition of sheddase meprin β by endogenous fetuin-B
      Ulrich Eckhard, Hagen Körschgen, Nele von Wiegen, Walter Stöcker, and F. Xavier Gomis-Rüth
      PNAS April 6, 2021 118 (14) e2023839118; https://doi.org/10.1073/pnas.2023839118
    • Open Access
      Crystal structure of schizorhodopsin reveals mechanism of inward proton pumping
      Akimitsu Higuchi, Wataru Shihoya, Masae Konno, Tatsuya Ikuta, Hideki Kandori, Keiichi Inoue, and Osamu Nureki
      PNAS April 6, 2021 118 (14) e2016328118; https://doi.org/10.1073/pnas.2016328118
  • Biophysics and Computational Biology

    • Open Access
      Deep generative selection models of T and B cell receptor repertoires with soNNia
      Giulio Isacchini, Aleksandra M. Walczak, Thierry Mora, and Armita Nourmohammad
      PNAS April 6, 2021 118 (14) e2023141118; https://doi.org/10.1073/pnas.2023141118
    • You have access
      Mapping temperature-dependent conformational change in the voltage-sensing domain of an engineered heat-activated K+ channel
      Hongbo Chen, Jiahua Deng, Qiang Cui, Baron Chanda, and Katherine Henzler-Wildman
      PNAS April 6, 2021 118 (14) e2017280118; https://doi.org/10.1073/pnas.2017280118
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      The structure of a minimum amyloid fibril core formed by necroptosis-mediating RHIM of human RIPK3
      Xialian Wu, Yeyang Ma, Kun Zhao, Jing Zhang, Yunpeng Sun, Yichen Li, Xingqi Dong, Hong Hu, Jing Liu, Jian Wang, Xia Zhang, Bing Li, Huayi Wang, Dan Li, Bo Sun, Junxia Lu, and Cong Liu
      PNAS April 6, 2021 118 (14) e2022933118; https://doi.org/10.1073/pnas.2022933118
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      Direct single-molecule imaging for diagnostic and blood screening assays
      Qiaoqiao Ruan, Patrick J. Macdonald, Kerry M. Swift, and Sergey Y. Tetin
      PNAS April 6, 2021 118 (14) e2025033118; https://doi.org/10.1073/pnas.2025033118
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      The myosin II coiled-coil domain atomic structure in its native environment
      Hamidreza Rahmani, Wen Ma, Zhongjun Hu, Nadia Daneshparvar, Dianne W. Taylor, J. Andrew McCammon, Thomas C. Irving, Robert J. Edwards, and Kenneth A. Taylor
      PNAS April 6, 2021 118 (14) e2024151118; https://doi.org/10.1073/pnas.2024151118
  • Cell Biology

    • Open Access
      Nanoanalytical analysis of bisphosphonate-driven alterations of microcalcifications using a 3D hydrogel system and in vivo mouse model
      Jessica L. Ruiz, Joshua D. Hutcheson, Luis Cardoso, Amirala Bakhshian Nik, Alexandra Condado de Abreu, Tan Pham, Fabrizio Buffolo, Sara Busatto, Stefania Federici, Andrea Ridolfi, Masanori Aikawa, Sergio Bertazzo, Paolo Bergese, Sheldon Weinbaum, and Elena Aikawa
      PNAS April 6, 2021 118 (14) e1811725118; https://doi.org/10.1073/pnas.1811725118
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      Selective autophagy of AKAP11 activates cAMP/PKA to fuel mitochondrial metabolism and tumor cell growth
      Zhiqiang Deng, Xianting Li, Marian Blanca Ramirez, Kerry Purtell, Insup Choi, Jia-Hong Lu, Qin Yu, and Zhenyu Yue
      PNAS April 6, 2021 118 (14) e2020215118; https://doi.org/10.1073/pnas.2020215118
  • Developmental Biology

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      The nuclear to cytoplasmic ratio directly regulates zygotic transcription in Drosophila through multiple modalities
      Sahla Syed, Henry Wilky, João Raimundo, Bomyi Lim, and Amanda A. Amodeo
      PNAS April 6, 2021 118 (14) e2010210118; https://doi.org/10.1073/pnas.2010210118
    • Open Access
      A single-cell resolution developmental atlas of hematopoietic stem and progenitor cell expansion in zebrafish
      Jun Xia, Zhixin Kang, Yuanyuan Xue, Yanyan Ding, Suwei Gao, Yifan Zhang, Peng Lv, Xinyu Wang, Dongyuan Ma, Lu Wang, Jing-Dong J. Han, and Feng Liu
      PNAS April 6, 2021 118 (14) e2015748118; https://doi.org/10.1073/pnas.2015748118
  • Ecology

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      Invasiveness is linked to greater commercial success in the global pet trade
      • From the Cover
      Jérôme M. W. Gippet and Cleo Bertelsmeier
      PNAS April 6, 2021 118 (14) e2016337118; https://doi.org/10.1073/pnas.2016337118
  • Evolution

    • Open Access
      An ancient, conserved gene regulatory network led to the rise of oral venom systems
      • From the Cover
      Agneesh Barua and Alexander S. Mikheyev
      PNAS April 6, 2021 118 (14) e2021311118; https://doi.org/10.1073/pnas.2021311118
    • Open Access
      A unique Malpighian tubule architecture in Tribolium castaneum informs the evolutionary origins of systemic osmoregulation in beetles
      Takashi Koyama, Muhammad Tayyib Naseem, Dennis Kolosov, Camilla Trang Vo, Duncan Mahon, Amanda Sofie Seger Jakobsen, Rasmus Lycke Jensen, Barry Denholm, Michael O’Donnell, and Kenneth Veland Halberg
      PNAS April 6, 2021 118 (14) e2023314118; https://doi.org/10.1073/pnas.2023314118
  • Genetics

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      Perfect Match Genomic Landscape strategy: Refinement and customization of reference genomes
      Kim Palacios-Flores, Jair García-Sotelo, Alejandra Castillo, Carina Uribe, Lucía Morales, Margareta Boege, Guillermo Dávila, Margarita Flores, and Rafael Palacios
      PNAS April 6, 2021 118 (14) e2025192118; https://doi.org/10.1073/pnas.2025192118
    • Open Access
      Use of NAD tagSeq II to identify growth phase-dependent alterations in E. coli RNA NAD+ capping
      Hailei Zhang, Huan Zhong, Xufeng Wang, Shoudong Zhang, Xiaojian Shao, Hao Hu, Zhiling Yu, Zongwei Cai, Xuemei Chen, and Yiji Xia
      PNAS April 6, 2021 118 (14) e2026183118; https://doi.org/10.1073/pnas.2026183118

      See companion article:

      • SPAAC-NAD-seq, a sensitive and accurate method to profile NAD+-capped transcripts
        - Mar 22, 2021
    • You have access
      Modeling DNA trapping of anticancer therapeutic targets using missense mutations identifies dominant synthetic lethal interactions
      Akil Hamza, Leanne Amitzi, Lina Ma, Maureen R. M. Driessen, Nigel J. O'Neil, and Philip Hieter
      PNAS April 6, 2021 118 (14) e2100240118; https://doi.org/10.1073/pnas.2100240118

      See companion article:

      • Setting molecular traps in yeast for identification of anticancer drug targets
        - Apr 14, 2021
    • Open Access
      ZYP1 is required for obligate cross-over formation and cross-over interference in Arabidopsis
      Martin G. France, Janina Enderle, Sarah Röhrig, Holger Puchta, F. Chris H. Franklin, and James D. Higgins
      PNAS April 6, 2021 118 (14) e2021671118; https://doi.org/10.1073/pnas.2021671118

      See companion article:

      • The synaptonemal complex imposes crossover interference and heterochiasmy in Arabidopsis
        - Mar 15, 2021

      See companion article:

      • Crossover interference: Just ZYP it
        - Mar 30, 2021
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      Upgraded CRISPR/Cas9 tools for tissue-specific mutagenesis in Drosophila
      Gabriel T. Koreman, Yineng Xu, Qinan Hu, Zijing Zhang, Sarah E. Allen, Mariana F. Wolfner, Bei Wang, and Chun Han
      PNAS April 6, 2021 118 (14) e2014255118; https://doi.org/10.1073/pnas.2014255118
  • Immunology and Inflammation

    • Open Access
      Signatures of immune dysfunction in HIV and HCV infection share features with chronic inflammation in aging and persist after viral reduction or elimination
      Cesar J. Lopez Angel, Edward A. Pham, Huixun Du, Francesco Vallania, Benjamin J. Fram, Kevin Perez, Thai Nguyen, Yael Rosenberg-Hasson, Aijaz Ahmed, Cornelia L. Dekker, Philip M. Grant, Purvesh Khatri, Holden T. Maecker, Jeffrey S. Glenn, Mark M. Davis, and David Furman
      PNAS April 6, 2021 118 (14) e2022928118; https://doi.org/10.1073/pnas.2022928118
    • Open Access
      TBK1 recruitment to STING activates both IRF3 and NF-κB that mediate immune defense against tumors and viral infections
      Seoyun Yum, Minghao Li, Yan Fang, and Zhijian J. Chen
      PNAS April 6, 2021 118 (14) e2100225118; https://doi.org/10.1073/pnas.2100225118
    • Open Access
      CD11c+CD88+CD317+ myeloid cells are critical mediators of persistent CNS autoimmunity
      Navid Manouchehri, Rehana Z. Hussain, Petra D. Cravens, Ekaterina Esaulova, Maxim N. Artyomov, Brian T. Edelson, Gregory F. Wu, Anne H. Cross, Richard Doelger, Nicolas Loof, Todd N. Eagar, Thomas G. Forsthuber, Laurent Calvier, Joachim Herz, and Olaf Stüve
      PNAS April 6, 2021 118 (14) e2014492118; https://doi.org/10.1073/pnas.2014492118

      See companion article:

      • CD317 puts the brakes on dendritic cell trafficking to the CNS
        - Apr 13, 2021
    • You have access
      Potent neutralization of Rift Valley fever virus by human monoclonal antibodies through fusion inhibition
      Nathaniel S. Chapman, Haiyan Zhao, Nurgun Kose, Jonna B. Westover, Birte Kalveram, Robin Bombardi, Jessica Rodriguez, Rachel Sutton, Joseph Genualdi, A. Desiree LaBeaud, Francis M. Mutuku, Phillip R. Pittman, Alexander N. Freiberg, Brian B. Gowen, Daved H. Fremont, and James E. Crowe Jr
      PNAS April 6, 2021 118 (14) e2025642118; https://doi.org/10.1073/pnas.2025642118
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      Active p38α causes macrovesicular fatty liver in mice
      Ilona Darlyuk-Saadon, Chen Bai, Chew Kiat Matthew Heng, Nechama Gilad, Wei-Ping Yu, Pei Yen Lim, Amaury Cazenave-Gassiot, Yongliang Zhang, W. S. Fred Wong, and David Engelberg
      PNAS April 6, 2021 118 (14) e2018069118; https://doi.org/10.1073/pnas.2018069118
  • Medical Sciences

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      ICAM-1 orchestrates the abscopal effect of tumor radiotherapy
      Yang Zhao, Ting Zhang, Yanpu Wang, Dehua Lu, Jinhong Du, Xun Feng, Haoyi Zhou, Ning Liu, Hua Zhu, Shangbin Qin, Chenxin Liu, Xianshu Gao, Zhi Yang, and Zhaofei Liu
      PNAS April 6, 2021 118 (14) e2010333118; https://doi.org/10.1073/pnas.2010333118
  • Microbiology

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      Bacterial-induced pH shifts link individual cell physiology to macroscale collective behavior
      Veeramuthu Dharanishanthi, Amit Orgad, Neta Rotem, Efrat Hagai, Jeny Kerstnus-Banchik, Julius Ben-Ari, Tim Harig, Srinivasa Rao Ravella, Stefan Schulz, and Yael Helman
      PNAS April 6, 2021 118 (14) e2014346118; https://doi.org/10.1073/pnas.2014346118
    • You have access
      c-di-AMP, a likely master regulator of bacterial K+ homeostasis machinery, activates a K+ exporter
      Tatiana B. Cereija, João P. L. Guerra, João M. P. Jorge, and João H. Morais-Cabral
      PNAS April 6, 2021 118 (14) e2020653118; https://doi.org/10.1073/pnas.2020653118
    • You have access
      Reverse genetics systems for contemporary isolates of respiratory syncytial virus enable rapid evaluation of antibody escape mutants
      Wendy K. Jo, Alina Schadenhofer, Andre Habierski, Franziska K. Kaiser, Giulietta Saletti, Tina Ganzenmueller, Elias Hage, Sibylle Haid, Thomas Pietschmann, Gesine Hansen, Thomas F. Schulz, Guus F. Rimmelzwaan, Albert D. M. E. Osterhaus, and Martin Ludlow
      PNAS April 6, 2021 118 (14) e2026558118; https://doi.org/10.1073/pnas.2026558118
    • Open Access
      A molecular link between cell wall biosynthesis, translation fidelity, and stringent response in Streptococcus pneumoniae
      Surya D. Aggarwal, Adrian J. Lloyd, Saigopalakrishna S. Yerneni, Ana Rita Narciso, Jennifer Shepherd, David I. Roper, Christopher G. Dowson, Sergio R. Filipe, and N. Luisa Hiller
      PNAS April 6, 2021 118 (14) e2018089118; https://doi.org/10.1073/pnas.2018089118
  • Neuroscience

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      Cortical ensembles selective for context
      Jordan P. Hamm, Yuriy Shymkiv, Shuting Han, Weijian Yang, and Rafael Yuste
      PNAS April 6, 2021 118 (14) e2026179118; https://doi.org/10.1073/pnas.2026179118
    • Open Access
      Network dynamics of hypothalamic feeding neurons
      Patrick Sweeney, Can Chen, Indika Rajapakse, and Roger D. Cone
      PNAS April 6, 2021 118 (14) e2011140118; https://doi.org/10.1073/pnas.2011140118
    • You have access
      Subthalamic low-frequency oscillations predict vulnerability to cocaine addiction
      Mickael Degoulet, Alix Tiran-Cappello, Etienne Combrisson, Christelle Baunez, and Yann Pelloux
      PNAS April 6, 2021 118 (14) e2024121118; https://doi.org/10.1073/pnas.2024121118
    • You have access
      A limited role of NKCC1 in telencephalic glutamatergic neurons for developing hippocampal network dynamics and behavior
      Jürgen Graf, Chuanqiang Zhang, Stephan Lawrence Marguet, Tanja Herrmann, Tom Flossmann, Robin Hinsch, Vahid Rahmati, Madlen Guenther, Christiane Frahm, Anja Urbach, Ricardo Melo Neves, Otto W. Witte, Stefan J. Kiebel, Dirk Isbrandt, Christian A. Hübner, Knut Holthoff, and Knut Kirmse
      PNAS April 6, 2021 118 (14) e2014784118; https://doi.org/10.1073/pnas.2014784118
    • You have access
      miR-218-2 regulates cognitive functions in the hippocampus through complement component 3–dependent modulation of synaptic vesicle release
      Si-Yao Lu, Chong-Lei Fu, Liang Liang, Bo Yang, Wei Shen, Qiu-Wen Wang, Yun Chen, Yan-Fen Chen, Yao-Nan Liu, Lin Zhu, Jieqing Zhao, Wei Shi, Shuangli Mi, and Jun Yao
      PNAS April 6, 2021 118 (14) e2021770118; https://doi.org/10.1073/pnas.2021770118
    • You have access
      Morphological integration of the human brain across adolescence and adulthood
      Ajay Nadig, Jakob Seidlitz, Cassidy L. McDermott, Siyuan Liu, Richard Bethlehem, Tyler M. Moore, Travis T. Mallard, Liv S. Clasen, Jonathan D. Blumenthal, François Lalonde, Ruben C. Gur, Raquel E. Gur, Edward T. Bullmore, Theodore D. Satterthwaite, and Armin Raznahan
      PNAS April 6, 2021 118 (14) e2023860118; https://doi.org/10.1073/pnas.2023860118
    • Open Access
      Presynaptic α2δ subunits are key organizers of glutamatergic synapses
      Clemens L. Schöpf, Cornelia Ablinger, Stefanie M. Geisler, Ruslan I. Stanika, Marta Campiglio, Walter A. Kaufmann, Benedikt Nimmervoll, Bettina Schlick, Johannes Brockhaus, Markus Missler, Ryuichi Shigemoto, and Gerald J. Obermair
      PNAS April 6, 2021 118 (14) e1920827118; https://doi.org/10.1073/pnas.1920827118
  • Physiology

    • You have access
      Transcriptional regulation of intermolecular Ca2+ signaling in hibernating ground squirrel cardiomyocytes: The myocardin–junctophilin axis
      Lei Yang, Rong-Chang Li, Bin Xiang, Yi-Chen Li, Li-Peng Wang, Yun-Bo Guo, Jing-Hui Liang, Xiao-Ting Wang, Tingting Hou, Xin Xing, Zeng-Quan Zhou, Haihong Ye, Ren-Qing Feng, Edward G. Lakatta, Zhen Chai, and Shi-Qiang Wang
      PNAS April 6, 2021 118 (14) e2025333118; https://doi.org/10.1073/pnas.2025333118
    • You have access
      Signal transduction through Cys-loop receptors is mediated by the nonspecific bumping of closely apposed domains
      Gisela D. Cymes and Claudio Grosman
      PNAS April 6, 2021 118 (14) e2021016118; https://doi.org/10.1073/pnas.2021016118
  • Plant Biology

    • You have access
      A Raf-like kinase is required for smoke-induced seed dormancy in Arabidopsis thaliana
      Inhye Lee, Eunsun Kim, Soobin Choi, Dayoung Kim, Wangyu Hong, Jungki Choi, Hyunmo Choi, Jimin Kim, Ganesh A. Sable, Kesavan Markkandan, Dongyeol Lim, Soon Ki Park, Soo Young Kim, Sumin Lee, and Moon-Soo Soh
      PNAS April 6, 2021 118 (14) e2020636118; https://doi.org/10.1073/pnas.2020636118
    • Open Access
      The diversity of stomatal development regulation in Callitriche is related to the intrageneric diversity in lifestyles
      Yuki Doll, Hiroyuki Koga, and Hirokazu Tsukaya
      PNAS April 6, 2021 118 (14) e2026351118; https://doi.org/10.1073/pnas.2026351118
  • Population Biology

    • Open Access
      Overdispersion in COVID-19 increases the effectiveness of limiting nonrepetitive contacts for transmission control
      Kim Sneppen, Bjarke Frost Nielsen, Robert J. Taylor, and Lone Simonsen
      PNAS April 6, 2021 118 (14) e2016623118; https://doi.org/10.1073/pnas.2016623118
    • Open Access
      Boosting can explain patterns of fluctuations of ratios of inapparent to symptomatic dengue virus infections
      Laura W. Alexander, Rotem Ben-Shachar, Leah C. Katzelnick, Guillermina Kuan, Angel Balmaseda, Eva Harris, and Mike Boots
      PNAS April 6, 2021 118 (14) e2013941118; https://doi.org/10.1073/pnas.2013941118
  • Psychological and Cognitive Sciences

    • Open Access
      Synchronous caregiving from birth to adulthood tunes humans’ social brain
      Adi Ulmer Yaniv, Roy Salomon, Shani Waidergoren, Ortal Shimon-Raz, Amir Djalovski, and Ruth Feldman
      PNAS April 6, 2021 118 (14) e2012900118; https://doi.org/10.1073/pnas.2012900118
    • You have access
      The cospecification of the shape and material properties of light permeable materials
      Phillip J. Marlow and Barton L. Anderson
      PNAS April 6, 2021 118 (14) e2024798118; https://doi.org/10.1073/pnas.2024798118
  • Sustainability Science

    • Open Access
      Twenty-year economic impacts of deworming
      Joan Hamory, Edward Miguel, Michael Walker, Michael Kremer, and Sarah Baird
      PNAS April 6, 2021 118 (14) e2023185118; https://doi.org/10.1073/pnas.2023185118
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Proceedings of the National Academy of Sciences: 118 (14)
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