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Natural cystatin C fragments inhibit GPR15-mediated HIV and SIV infection without interfering with GPR15L signaling
Contributed by Beatrice H. Hahn, December 5, 2020 (sent for review November 16, 2020; reviewed by Shibo Jiang and Wesley I. Sundquist)

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Article Information
- Published in issue January 19, 2021.
- Published online January 11, 2021.
Author Information
- Manuel Hayna,1,
- Andrea Blötza,1,
- Armando Rodríguezb,c,d,
- Solange Vidale,
- Nico Preisingb,
- Ludger Ständkerb,
- Sebastian Wiesec,
- Christina M. Stürzela,
- Mirja Harmsa,
- Rüdiger Grossa,
- Christoph Jungf,
- Miriam Kieneg,
- Timo Jacobf,
- Stefan Pöhlmanng,h,
- Wolf-Georg Forssmannd,
- Jan Müncha,
- Konstantin M. J. Sparrera,
- Klaus Seuwene,
- Beatrice H. Hahni,j,2, and
- Frank Kirchhoffa,2
- aInstitute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany;
- bCore Facility Functional Peptidomics, Ulm University Medical Center, 89081 Ulm, Germany;
- cCore Unit Mass Spectrometry and Proteomics, Ulm University Medical Center, 89081 Ulm, Germany;
- dPHARIS Biotec GmbH, 30625 Hannover, Germany;
- eNovartis Institutes for Biomedical Research, 4056 Basel, Switzerland;
- fInstitute of Electrochemistry, Ulm University, 89081 Ulm, Germany;
- gInfection Biology Unit, German Primate Center–Leibniz Institute for Primate Research, 37077 Göttingen, Germany;
- hFaculty of Biology and Psychology, University Göttingen, 37073 Göttingen, Germany;
- iDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6076;
- jDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6076
Contributed by Beatrice H. Hahn, December 5, 2020 (sent for review November 16, 2020; reviewed by Shibo Jiang and Wesley I. Sundquist)
Footnotes
↵1M. Hayn and A.B. contributed equally to this work.
- ↵2To whom correspondence may be addressed. Email: bhahn{at}pennmedicine.upenn.edu or frank.kirchhoff{at}uni-ulm.de.
Author contributions: A.B., L.S., S.W., S.P., K.M.J.S., K.S., and F.K. designed research; M. Hayn, A.B., A.R., S.V., N.P., S.W., C.M.S., M. Harms, R.G., C.J., M.K., and T.J. performed research; C.M.S., W.-G.F., J.M., and B.H.H. contributed new reagents/analytic tools; M. Hayn, A.B., A.R., L.S., S.W., C.J., T.J., S.P., K.M.J.S., K.S., and F.K. analyzed data; and B.H.H. and F.K. wrote the paper.
Reviewers: S.J., Fudan University; and W.I.S., University of Utah Medical Center.
The authors declare no competing interest.
This article contains supporting information online at https://www.pnas.org/lookup/suppl/doi:10.1073/pnas.2023776118/-/DCSupplemental.
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