Proceedings of the National Academy of Sciences: 118 (3)

New Research In

January 19, 2021; vol. 118 no. 3

This Week in PNAS

This week's research highlights

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In This Issue
PNAS January 19, 2021 118 (3) eiti0221118; https://doi.org/10.1073/iti0321118

Opinion

Leading scientists discuss current issues

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Opinion: Standardizing gene product nomenclature—a call to action
Front Matter
Kenji Fujiyoshi, Elspeth A. Bruford, Pawel Mroz, Cynthe L. Sims, Timothy J. O’Leary, Anthony W. I. Lo, Neng Chen, Nimesh R. Patel, Keyur Pravinchandra Patel, Barbara Seliger, Mingyang Song, Federico A. Monzon, Alexis B. Carter, Margaret L. Gulley, Susan M. Mockus, Thuy L. Phung, Harriet Feilotter, Heather E. Williams, and Shuji Ogino

PNAS January 19, 2021 118 (3) e2025207118; https://doi.org/10.1073/pnas.2025207118

News Feature

An in-depth look at trending science issues

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News Feature: Realizing the roads of the future
Front Matter
Sid Perkins

PNAS January 19, 2021 118 (3) e2024425118; https://doi.org/10.1073/pnas.2024425118

Profile

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Profile of David M. Kingsley
Beth Azar

PNAS January 19, 2021 118 (3) e2025633118; https://doi.org/10.1073/pnas.2025633118
See companion article:
Fitness maps to a large-effect locus in introduced stickleback populations
- Jan 07, 2021
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Profile of Dolph Schluter
Beth Azar

PNAS January 19, 2021 118 (3) e2025630118; https://doi.org/10.1073/pnas.2025630118
See companion article:
Fitness maps to a large-effect locus in introduced stickleback populations
- Jan 07, 2021

Commentaries

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A cancer in hybrids
Chesley M. Johnson and Nitin Phadnis

PNAS January 19, 2021 118 (3) e2023488118; https://doi.org/10.1073/pnas.2023488118
See companion article:
Oncogenic allelic interaction in Xiphophorus highlights hybrid incompatibility
- Nov 09, 2020
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Diversification spins a heatwave safety net for fisheries
Malin L. Pinsky

PNAS January 19, 2021 118 (3) e2024412118; https://doi.org/10.1073/pnas.2024412118
See companion article:
Climate shock effects and mediation in fisheries
- Jan 04, 2021

Perspective

Open Access
Vaccinology in the post−COVID-19 era
Rino Rappuoli, Ennio De Gregorio, Giuseppe Del Giudice, Sanjay Phogat, Simone Pecetta, Mariagrazia Pizza, and Emmanuel Hanon

PNAS January 19, 2021 118 (3) e2020368118; https://doi.org/10.1073/pnas.2020368118

Letters

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Who’s fooling whom in the science of magic?
Geoff G. Cole

PNAS January 19, 2021 118 (3) e2019540118; https://doi.org/10.1073/pnas.2019540118
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Reply to Cole: Magic and deception—do magicians mislead science?
Alice Pailhès and Gustav Kuhn

PNAS January 19, 2021 118 (3) e2022099118; https://doi.org/10.1073/pnas.2022099118
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Influencing choices with conversational primes: How a magic trick unconsciously influences card choices
- Jul 13, 2020
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UVB stimulates production of enkephalins and other neuropeptides by skin-resident cells
Andrzej T. Slominski, Radomir M. Slominski, and Chander Raman

PNAS January 19, 2021 118 (3) e2020425118; https://doi.org/10.1073/pnas.2020425118
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Reply to Slominski et al.: UVB irradiation induces proenkephalin⁺ regulatory T cells with a wound-healing function
Hiroaki Shime, Mizuyu Odanaka, Makoto Tsuiji, Takuma Matoba, Masaki Imai, Yoshiaki Yasumizu, Ryuta Uraki, Kiyoshi Minohara, Maiko Watanabe, Anthony John Bonito, Hidehiro Fukuyama, Naganari Ohkura, Shimon Sakaguchi, Akimichi Morita, and Sayuri Yamazaki

PNAS January 19, 2021 118 (3) e2021919118; https://doi.org/10.1073/pnas.2021919118
See companion article:
Proenkephalin⁺ regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function
- Aug 07, 2020
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Viruses from poultry and livestock pose continuous threats to human beings
Si Chen, Liying Zhang, Lin Wang, Hongsheng Ouyang, and Linzhu Ren

PNAS January 19, 2021 118 (3) e2022344118; https://doi.org/10.1073/pnas.2022344118

Brief Report

Open Access
Effect of “finite pool of worry” and COVID-19 on UK climate change perceptions
Darrick Evensen, Lorraine Whitmarsh, Phil Bartie, Patrick Devine-Wright, Jennifer Dickie, Adam Varley, Stacia Ryder, and Adam Mayer

PNAS January 19, 2021 118 (3) e2018936118; https://doi.org/10.1073/pnas.2018936118

Physical Sciences

Applied Physical Sciences
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  X-ray linear dichroic ptychography
  Yuan Hung Lo, Jihan Zhou, Arjun Rana, Drew Morrill, Christian Gentry, Bjoern Enders, Young-Sang Yu, Chang-Yu Sun, David A. Shapiro, Roger W. Falcone, Henry C. Kapteyn, Margaret M. Murnane, Pupa U. P. A. Gilbert, and Jianwei Miao
  
  PNAS January 19, 2021 118 (3) e2019068118; https://doi.org/10.1073/pnas.2019068118
- Open Access
  Avian mud nest architecture by self-secreted saliva
  Yeonsu Jung, Sohyun Jung, Sang-im Lee, Wonjung Kim, and Ho-Young Kim
  
  PNAS January 19, 2021 118 (3) e2018509118; https://doi.org/10.1073/pnas.2018509118
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  Sculpting crystals one Burgers vector at a time: Toward colloidal lattice robot swarms
  Bryan VanSaders and Sharon C. Glotzer
  
  PNAS January 19, 2021 118 (3) e2017377118; https://doi.org/10.1073/pnas.2017377118
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  Induced transparency by interference or polarization
  Changqing Wang, Xuefeng Jiang, William R. Sweeney, Chia Wei Hsu, Yiming Liu, Guangming Zhao, Bo Peng, Mengzhen Zhang, Liang Jiang, A. Douglas Stone, and Lan Yang
  
  PNAS January 19, 2021 118 (3) e2012982118; https://doi.org/10.1073/pnas.2012982118
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  Topological metals and finite-momentum superconductors
  Noah F. Q. Yuan and Liang Fu
  
  PNAS January 19, 2021 118 (3) e2019063118; https://doi.org/10.1073/pnas.2019063118
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  Time-reversal symmetry breaking in the Fe-chalcogenide superconductors
  Nader Zaki, Genda Gu, Alexei Tsvelik, Congjun Wu, and Peter D. Johnson
  
  PNAS January 19, 2021 118 (3) e2007241118; https://doi.org/10.1073/pnas.2007241118
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  Foraging trade-offs, flagellar arrangements, and flow architecture of planktonic protists
  Lasse Tor Nielsen and Thomas Kiørboe
  
  PNAS January 19, 2021 118 (3) e2009930118; https://doi.org/10.1073/pnas.2009930118
Chemistry
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  Imaging conical intersection dynamics during azobenzene photoisomerization by ultrafast X-ray diffraction
  Daniel Keefer, Flavia Aleotti, Jérémy R. Rouxel, Francesco Segatta, Bing Gu, Artur Nenov, Marco Garavelli, and Shaul Mukamel
  
  PNAS January 19, 2021 118 (3) e2022037118; https://doi.org/10.1073/pnas.2022037118
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  The 3-O-sulfation of heparan sulfate modulates protein binding and lyase degradation
  Pradeep Chopra, Apoorva Joshi, Jiandong Wu, Weigang Lu, Tejabhiram Yadavalli, Margreet A. Wolfert, Deepak Shukla, Joseph Zaia, and Geert-Jan Boons
  
  PNAS January 19, 2021 118 (3) e2012935118; https://doi.org/10.1073/pnas.2012935118
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  Thermodynamics of interfaces extended to nanoscales by introducing integral and differential surface tensions
  W. Dong
  
  PNAS January 19, 2021 118 (3) e2019873118; https://doi.org/10.1073/pnas.2019873118
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  Ferric heme as a CO/NO sensor in the nuclear receptor Rev-Erbß by coupling gas binding to electron transfer
  Anindita Sarkar, Eric L. Carter, Jill B. Harland, Amy L. Speelman, Nicolai Lehnert, and Stephen W. Ragsdale
  
  PNAS January 19, 2021 118 (3) e2016717118; https://doi.org/10.1073/pnas.2016717118
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  Stone–Wales defects preserve hyperuniformity in amorphous two-dimensional networks
  Duyu Chen, Yu Zheng, Lei Liu, Ge Zhang, Mohan Chen, Yang Jiao, and Houlong Zhuang
  
  PNAS January 19, 2021 118 (3) e2016862118; https://doi.org/10.1073/pnas.2016862118
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  Modulation of immune cell reactivity with cis-binding Siglec agonists
  Corleone S. Delaveris, Shannon H. Chiu, Nicholas M. Riley, and Carolyn R. Bertozzi
  
  PNAS January 19, 2021 118 (3) e2012408118; https://doi.org/10.1073/pnas.2012408118
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  Cellular autofluorescence is magnetic field sensitive
  Noboru Ikeya and Jonathan R. Woodward
  
  PNAS January 19, 2021 118 (3) e2018043118; https://doi.org/10.1073/pnas.2018043118
Computer Sciences
- Open Access
  Unsupervised neural network models of the ventral visual stream
  Chengxu Zhuang, Siming Yan, Aran Nayebi, Martin Schrimpf, Michael C. Frank, James J. DiCarlo, and Daniel L. K. Yamins
  
  PNAS January 19, 2021 118 (3) e2014196118; https://doi.org/10.1073/pnas.2014196118
Earth, Atmospheric, and Planetary Sciences
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  Garnet sand reveals rock recycling processes in the youngest exhumed high- and ultrahigh-pressure terrane on Earth
  Suzanne L. Baldwin, Jan Schönig, Joseph P. Gonzalez, Hugh Davies, and Hilmar von Eynatten
  
  PNAS January 19, 2021 118 (3) e2017231118; https://doi.org/10.1073/pnas.2017231118
- Open Access
  A modern scleractinian coral with a two-component calcite–aragonite skeleton
  Jarosław Stolarski, Ismael Coronado, Jack G. Murphy, Marcelo V. Kitahara, Katarzyna Janiszewska, Maciej Mazur, Anne M. Gothmann, Anne-Sophie Bouvier, Johanna Marin-Carbonne, Michelle L. Taylor, Andrea M. Quattrini, Catherine S. McFadden, John A. Higgins, Laura F. Robinson, and Anders Meibom
  
  PNAS January 19, 2021 118 (3) e2013316117; first published December 15, 2020. https://doi.org/10.1073/pnas.2013316117
Engineering
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  Photosynthesis-assisted remodeling of three-dimensional printed structures
  Kunhao Yu, Zhangzhengrong Feng, Haixu Du, An Xin, Kyung Hoon Lee, Ketian Li, Yipin Su, Qiming Wang, Nicholas X. Fang, and Chiara Daraio
  
  PNAS January 19, 2021 118 (3) e2016524118; https://doi.org/10.1073/pnas.2016524118
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  High-speed compressed-sensing fluorescence lifetime imaging microscopy of live cells
  Yayao Ma, Youngjae Lee, Catherine Best-Popescu, and Liang Gao
  
  PNAS January 19, 2021 118 (3) e2004176118; https://doi.org/10.1073/pnas.2004176118
- Open Access
  In silico dynamics of COVID-19 phenotypes for optimizing clinical management
  Chrysovalantis Voutouri, Mohammad Reza Nikmaneshi, C. Corey Hardin, Ankit B. Patel, Ashish Verma, Melin J. Khandekar, Sayon Dutta, Triantafyllos Stylianopoulos, Lance L. Munn, and Rakesh K. Jain
  
  PNAS January 19, 2021 118 (3) e2021642118; https://doi.org/10.1073/pnas.2021642118
- Open Access
  Prediction of Alzheimer’s disease-specific phospholipase c gamma-1 SNV by deep learning-based approach for high-throughput screening
  Sung-Hyun Kim, Sumin Yang, Key-Hwan Lim, Euiseng Ko, Hyun-Jun Jang, Mingon Kang, Pann-Ghill Suh, and Jae-Yeol Joo
  
  PNAS January 19, 2021 118 (3) e2011250118; https://doi.org/10.1073/pnas.2011250118
Environmental Sciences
- Open Access
  Bioavailable soil Pb minimized by in situ transformation to plumbojarosite
  Ranju R. Karna, Matt R. Noerpel, Clay Nelson, Brittany Elek, Karen Herbin-Davis, Gary Diamond, Karen Bradham, David J. Thomas, and Kirk G. Scheckel
  
  PNAS January 19, 2021 118 (3) e2020315117; first published December 21, 2020. https://doi.org/10.1073/pnas.2020315117
Physics
- Open Access
  Observation of liquid glass in suspensions of ellipsoidal colloids
  Jörg Roller, Aleena Laganapan, Janne-Mieke Meijer, Matthias Fuchs, and Andreas Zumbusch
  
  PNAS January 19, 2021 118 (3) e2018072118; https://doi.org/10.1073/pnas.2018072118
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  Emergence of homochirality in large molecular systems
  Gabin Laurent, David Lacoste, and Pierre Gaspard
  
  PNAS January 19, 2021 118 (3) e2012741118; https://doi.org/10.1073/pnas.2012741118

Biological Sciences

Applied Biological Sciences
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  High-speed compressed-sensing fluorescence lifetime imaging microscopy of live cells
  Yayao Ma, Youngjae Lee, Catherine Best-Popescu, and Liang Gao
  
  PNAS January 19, 2021 118 (3) e2004176118; https://doi.org/10.1073/pnas.2004176118
Biochemistry
- You have access
  Modulation of immune cell reactivity with cis-binding Siglec agonists
  Corleone S. Delaveris, Shannon H. Chiu, Nicholas M. Riley, and Carolyn R. Bertozzi
  
  PNAS January 19, 2021 118 (3) e2012408118; https://doi.org/10.1073/pnas.2012408118
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  ACTL6A promotes repair of cisplatin-induced DNA damage, a new mechanism of platinum resistance in cancer
  Yang Xiao, Fang-Tsyr Lin, and Weei-Chin Lin
  
  PNAS January 19, 2021 118 (3) e2015808118; https://doi.org/10.1073/pnas.2015808118
- Open Access
  Citramalate synthase yields a biosynthetic pathway for isoleucine and straight- and branched-chain ester formation in ripening apple fruit
  Nobuko Sugimoto, Philip Engelgau, A. Daniel Jones, Jun Song, and Randolph Beaudry
  
  PNAS January 19, 2021 118 (3) e2009988118; https://doi.org/10.1073/pnas.2009988118
- Open Access
  Small-molecule endoplasmic reticulum proteostasis regulator acts as a broad-spectrum inhibitor of dengue and Zika virus infections
  Katherine M. Almasy, Jonathan P. Davies, Samantha M. Lisy, Reyhaneh Tirgar, Sirena C. Tran, and Lars Plate
  
  PNAS January 19, 2021 118 (3) e2012209118; https://doi.org/10.1073/pnas.2012209118
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  The amphibian antimicrobial peptide uperin 3.5 is a cross-α/cross-β chameleon functional amyloid
  Nir Salinas, Einav Tayeb-Fligelman, Massimo D. Sammito, Daniel Bloch, Raz Jelinek, Dror Noy, Isabel Usón, and Meytal Landau
  
  PNAS January 19, 2021 118 (3) e2014442118; https://doi.org/10.1073/pnas.2014442118
Biophysics and Computational Biology
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  X-ray linear dichroic ptychography
  Yuan Hung Lo, Jihan Zhou, Arjun Rana, Drew Morrill, Christian Gentry, Bjoern Enders, Young-Sang Yu, Chang-Yu Sun, David A. Shapiro, Roger W. Falcone, Henry C. Kapteyn, Margaret M. Murnane, Pupa U. P. A. Gilbert, and Jianwei Miao
  
  PNAS January 19, 2021 118 (3) e2019068118; https://doi.org/10.1073/pnas.2019068118
- Open Access
  Avian mud nest architecture by self-secreted saliva
  Yeonsu Jung, Sohyun Jung, Sang-im Lee, Wonjung Kim, and Ho-Young Kim
  
  PNAS January 19, 2021 118 (3) e2018509118; https://doi.org/10.1073/pnas.2018509118
- Open Access
  Immature HIV-1 assembles from Gag dimers leaving partial hexamers at lattice edges as potential substrates for proteolytic maturation
  Aaron Tan, Alexander J. Pak, Dustin R. Morado, Gregory A. Voth, and John A. G. Briggs
  
  PNAS January 19, 2021 118 (3) e2020054118; https://doi.org/10.1073/pnas.2020054118
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  Structure and activation mechanism of the yeast RNA Pol II CTD kinase CTDK-1 complex
  Yihu Xie, Christopher L. Lord, Bradley P. Clarke, Austin L. Ivey, Pate S. Hill, W. Hayes McDonald, Susan R. Wente, and Yi Ren
  
  PNAS January 19, 2021 118 (3) e2019163118; https://doi.org/10.1073/pnas.2019163118
Cell Biology
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  Cellular autofluorescence is magnetic field sensitive
  Noboru Ikeya and Jonathan R. Woodward
  
  PNAS January 19, 2021 118 (3) e2018043118; https://doi.org/10.1073/pnas.2018043118
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  Interplay between desmoglein2 and hypoxia controls metastasis in breast cancer
  Po-Hao Chang, Min-Che Chen, Ya-Ping Tsai, Grace Y. T. Tan, Pang-Hung Hsu, Yung-Ming Jeng, Yi-Fang Tsai, Muh-Hwa Yang, and Wendy W. Hwang-Verslues
  
  PNAS January 19, 2021 118 (3) e2014408118; https://doi.org/10.1073/pnas.2014408118
- Open Access
  ATRX and RECQ5 define distinct homologous recombination subpathways
  Amira Elbakry, Szilvia Juhász, Ki Choi Chan, and Markus Löbrich
  
  PNAS January 19, 2021 118 (3) e2010370118; https://doi.org/10.1073/pnas.2010370118
Developmental Biology
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  Placental trophoblast syncytialization potentiates macropinocytosis via mTOR signaling to adapt to reduced amino acid supply
  Xuan Shao, Guangming Cao, Dunjin Chen, Juan Liu, Bolan Yu, Ming Liu, Yu-Xia Li, Bin Cao, Yoel Sadovsky, and Yan-Ling Wang
  
  PNAS January 19, 2021 118 (3) e2017092118; https://doi.org/10.1073/pnas.2017092118
- Open Access
  OCT4 induces embryonic pluripotency via STAT3 signaling and metabolic mechanisms
  Giuliano G. Stirparo, Agata Kurowski, Ayaka Yanagida, Lawrence E. Bates, Stanley E. Strawbridge, Siarhei Hladkou, Hannah T. Stuart, Thorsten E. Boroviak, Jose C. R. Silva, and Jennifer Nichols
  
  PNAS January 19, 2021 118 (3) e2008890118; https://doi.org/10.1073/pnas.2008890118
Ecology
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  Foraging trade-offs, flagellar arrangements, and flow architecture of planktonic protists
  Lasse Tor Nielsen and Thomas Kiørboe
  
  PNAS January 19, 2021 118 (3) e2009930118; https://doi.org/10.1073/pnas.2009930118
- You have access
  The decline of mammal functional and evolutionary diversity worldwide
  From the Cover
  
  Jedediah F. Brodie, Sara Williams, and Brittany Garner
  
  PNAS January 19, 2021 118 (3) e1921849118; https://doi.org/10.1073/pnas.1921849118
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  Natural resistance to worms exacerbates bovine tuberculosis severity independently of worm coinfection
  Vanessa O. Ezenwa, Sarah A. Budischak, Peter Buss, Mauricio Seguel, Gordon Luikart, Anna E. Jolles, and Kaori Sakamoto
  
  PNAS January 19, 2021 118 (3) e2015080118; https://doi.org/10.1073/pnas.2015080118
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  Spatial and evolutionary predictability of phytochemical diversity
  Emmanuel Defossez, Camille Pitteloud, Patrice Descombes, Gaétan Glauser, Pierre-Marie Allard, Tom W. N. Walker, Pilar Fernandez-Conradi, Jean-Luc Wolfender, Loïc Pellissier, and Sergio Rasmann
  
  PNAS January 19, 2021 118 (3) e2013344118; https://doi.org/10.1073/pnas.2013344118
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  Shell mineralogy of a foundational marine species, Mytilus californianus, over half a century in a changing ocean
  Elizabeth M. Bullard, Ivan Torres, Tianqi Ren, Olivia A. Graeve, and Kaustuv Roy
  
  PNAS January 19, 2021 118 (3) e2004769118; https://doi.org/10.1073/pnas.2004769118
Environmental Sciences
- Open Access
  Bioavailable soil Pb minimized by in situ transformation to plumbojarosite
  Ranju R. Karna, Matt R. Noerpel, Clay Nelson, Brittany Elek, Karen Herbin-Davis, Gary Diamond, Karen Bradham, David J. Thomas, and Kirk G. Scheckel
  
  PNAS January 19, 2021 118 (3) e2020315117; first published December 21, 2020. https://doi.org/10.1073/pnas.2020315117
- Open Access
  Satellites can reveal global extent of forced labor in the world’s fishing fleet
  From the Cover
  
  Gavin G. McDonald, Christopher Costello, Jennifer Bone, Reniel B. Cabral, Valerie Farabee, Timothy Hochberg, David Kroodsma, Tracey Mangin, Kyle C. Meng, and Oliver Zahn
  
  PNAS January 19, 2021 118 (3) e2016238117; first published December 21, 2020. https://doi.org/10.1073/pnas.2016238117
Evolution
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  Fitness maps to a large-effect locus in introduced stickleback populations
  Inaugural Article
  
  Dolph Schluter, Kerry B. Marchinko, Matthew E. Arnegard, Haili Zhang, Shannon D. Brady, Felicity C. Jones, Michael A. Bell, and David M. Kingsley
  
  PNAS January 19, 2021 118 (3) e1914889118; https://doi.org/10.1073/pnas.1914889118
  
  See companion article:
  Profile of David M. Kingsley
  - Jan 11, 2021
  
  Profile of Dolph Schluter
  - Jan 11, 2021
- Open Access
  A modern scleractinian coral with a two-component calcite–aragonite skeleton
  Jarosław Stolarski, Ismael Coronado, Jack G. Murphy, Marcelo V. Kitahara, Katarzyna Janiszewska, Maciej Mazur, Anne M. Gothmann, Anne-Sophie Bouvier, Johanna Marin-Carbonne, Michelle L. Taylor, Andrea M. Quattrini, Catherine S. McFadden, John A. Higgins, Laura F. Robinson, and Anders Meibom
  
  PNAS January 19, 2021 118 (3) e2013316117; first published December 15, 2020. https://doi.org/10.1073/pnas.2013316117
- You have access
  Negative selection on human genes underlying inborn errors depends on disease outcome and both the mode and mechanism of inheritance
  Franck Rapaport, Bertrand Boisson, Anne Gregor, Vivien Béziat, Stéphanie Boisson-Dupuis, Jacinta Bustamante, Emmanuelle Jouanguy, Anne Puel, Jérémie Rosain, Qian Zhang, Shen-Ying Zhang, Joseph G. Gleeson, Lluis Quintana-Murci, Jean-Laurent Casanova, Laurent Abel, and Etienne Patin
  
  PNAS January 19, 2021 118 (3) e2001248118; https://doi.org/10.1073/pnas.2001248118
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  Diversification of mammalian deltaviruses by host shifting
  Laura M. Bergner, Richard J. Orton, Alice Broos, Carlos Tello, Daniel J. Becker, Jorge E. Carrera, Arvind H. Patel, Roman Biek, and Daniel G. Streicker
  
  PNAS January 19, 2021 118 (3) e2019907118; https://doi.org/10.1073/pnas.2019907118
- Open Access
  The harsh microenvironment in early breast cancer selects for a Warburg phenotype
  Mehdi Damaghi, Jeffrey West, Mark Robertson-Tessi, Liping Xu, Meghan C. Ferrall-Fairbanks, Paul A. Stewart, Erez Persi, Brooke L. Fridley, Philipp M. Altrock, Robert A. Gatenby, Peter A. Sims, Alexander R. A. Anderson, and Robert J. Gillies
  
  PNAS January 19, 2021 118 (3) e2011342118; https://doi.org/10.1073/pnas.2011342118
Immunology and Inflammation
- Open Access
  Physiological role of the 3′IgH CBEs super-anchor in antibody class switching
  From the Cover
  
  Xuefei Zhang, Hye Suk Yoon, Aimee M. Chapdelaine-Williams, Nia Kyritsis, and Frederick W. Alt
  
  PNAS January 19, 2021 118 (3) e2024392118; https://doi.org/10.1073/pnas.2024392118
  
  See companion article:
  An insulator that regulates chromatin extrusion and class switch recombination
  - Jan 21, 2021
- Open Access
  Droplet-based mRNA sequencing of fixed and permeabilized cells by CLInt-seq allows for antigen-specific TCR cloning
  Pavlo A. Nesterenko, Jami McLaughlin, Donghui Cheng, Nathanael J. Bangayan, Giselle Burton Sojo, Christopher S. Seet, Yu Qin, Zhiyuan Mao, Matthew B. Obusan, John W. Phillips, and Owen N. Witte
  
  PNAS January 19, 2021 118 (3) e2021190118; https://doi.org/10.1073/pnas.2021190118
- Open Access
  Natural cystatin C fragments inhibit GPR15-mediated HIV and SIV infection without interfering with GPR15L signaling
  Manuel Hayn, Andrea Blötz, Armando Rodríguez, Solange Vidal, Nico Preising, Ludger Ständker, Sebastian Wiese, Christina M. Stürzel, Mirja Harms, Rüdiger Gross, Christoph Jung, Miriam Kiene, Timo Jacob, Stefan Pöhlmann, Wolf-Georg Forssmann, Jan Münch, Konstantin M. J. Sparrer, Klaus Seuwen, Beatrice H. Hahn, and Frank Kirchhoff
  
  PNAS January 19, 2021 118 (3) e2023776118; https://doi.org/10.1073/pnas.2023776118
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  An in vivo screen of noncoding loci reveals that Daedalus is a gatekeeper of an Ikaros-dependent checkpoint during haematopoiesis
  Christian C. D. Harman, Will Bailis, Jun Zhao, Louisa Hill, Rihao Qu, Ruaidhrí P. Jackson, Justin A. Shyer, Holly R. Steach, Yuval Kluger, Loyal A. Goff, John L. Rinn, Adam Williams, Jorge Henao-Mejia, and Richard A. Flavell
  
  PNAS January 19, 2021 118 (3) e1918062118; https://doi.org/10.1073/pnas.1918062118
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  Altered ratio of dendritic cell subsets in skin-draining lymph nodes promotes Th2-driven contact hypersensitivity
  Hannah L. Miller, Prabhakar Sairam Andhey, Melissa K. Swiecki, Bruce A. Rosa, Konstantin Zaitsev, Alexandra-Chloe Villani, Makedonka Mitreva, Maxim N. Artyomov, Susan Gilfillan, Marina Cella, and Marco Colonna
  
  PNAS January 19, 2021 118 (3) e2021364118; https://doi.org/10.1073/pnas.2021364118
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  Acute skin exposure to ultraviolet light triggers neutrophil-mediated kidney inflammation
  Sladjana Skopelja-Gardner, Joyce Tai, Xizhang Sun, Lena Tanaka, James A. Kuchenbecker, Jessica M. Snyder, Paul Kubes, Tomas Mustelin, and Keith B. Elkon
  
  PNAS January 19, 2021 118 (3) e2019097118; https://doi.org/10.1073/pnas.2019097118
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  Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer’s disease
  Daniel C. Ellwanger, Shoutang Wang, Simone Brioschi, Zhifei Shao, Lydia Green, Ryan Case, Daniel Yoo, Dawn Weishuhn, Palaniswami Rathanaswami, Jodi Bradley, Sara Rao, Diana Cha, Peng Luan, Shilpa Sambashivan, Susan Gilfillan, Samuel A. Hasson, Ian N. Foltz, Menno van Lookeren Campagne, and Marco Colonna
  
  PNAS January 19, 2021 118 (3) e2017742118; https://doi.org/10.1073/pnas.2017742118
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  PNAS January 19, 2021 118 (3) e2015416118; https://doi.org/10.1073/pnas.2015416118
Medical Sciences
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  PNAS January 19, 2021 118 (3) e2021642118; https://doi.org/10.1073/pnas.2021642118
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  PNAS January 19, 2021 118 (3) e2018027118; https://doi.org/10.1073/pnas.2018027118
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  PNAS January 19, 2021 118 (3) e2014810118; https://doi.org/10.1073/pnas.2014810118
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  The secretome mouse provides a genetic platform to delineate tissue-specific in vivo secretion
  Jie Liu, Ji Yong Jang, Mehdi Pirooznia, Shihui Liu, and Toren Finkel
  
  PNAS January 19, 2021 118 (3) e2005134118; https://doi.org/10.1073/pnas.2005134118
Microbiology
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  PNAS January 19, 2021 118 (3) e2014195118; https://doi.org/10.1073/pnas.2014195118
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  PNAS January 19, 2021 118 (3) e2020732118; https://doi.org/10.1073/pnas.2020732118
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  PNAS January 19, 2021 118 (3) e2019455118; https://doi.org/10.1073/pnas.2019455118
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  PNAS January 19, 2021 118 (3) e2015149118; https://doi.org/10.1073/pnas.2015149118
Neuroscience
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  PNAS January 19, 2021 118 (3) e2014196118; https://doi.org/10.1073/pnas.2014196118
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  PNAS January 19, 2021 118 (3) e2022580118; https://doi.org/10.1073/pnas.2022580118
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  PNAS January 19, 2021 118 (3) e2022551118; https://doi.org/10.1073/pnas.2022551118
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  PNAS January 19, 2021 118 (3) e2021843118; https://doi.org/10.1073/pnas.2021843118
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  Multiple signaling pathways are essential for synapse formation induced by synaptic adhesion molecules
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  PNAS January 19, 2021 118 (3) e2000173118; https://doi.org/10.1073/pnas.2000173118
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  PNAS January 19, 2021 118 (3) e2002574118; https://doi.org/10.1073/pnas.2002574118
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  Crucial role for CA2 inputs in the sequential organization of CA1 time cells supporting memory
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  Christopher J. MacDonald and Susumu Tonegawa
  
  PNAS January 19, 2021 118 (3) e2020698118; https://doi.org/10.1073/pnas.2020698118
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  Drebrin regulates cytoskeleton dynamics in migrating neurons through interaction with CXCR4
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  PNAS January 19, 2021 118 (3) e2009493118; https://doi.org/10.1073/pnas.2009493118
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  A subset of spinal dorsal horn interneurons crucial for gating touch-evoked pain-like behavior
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  PNAS January 19, 2021 118 (3) e2020574118; https://doi.org/10.1073/pnas.2020574118
Pharmacology
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  Orthosteric–allosteric dual inhibitors of PfHT1 as selective antimalarial agents
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  PNAS January 19, 2021 118 (3) e2017749118; https://doi.org/10.1073/pnas.2017749118
Physiology
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  Goblet cell LRRC26 regulates BK channel activation and protects against colitis in mice
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  PNAS January 19, 2021 118 (3) e2019149118; https://doi.org/10.1073/pnas.2019149118
Plant Biology
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  Chromatin phosphoproteomics unravels a function for AT-hook motif nuclear localized protein AHL13 in PAMP-triggered immunity
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  PNAS January 19, 2021 118 (3) e2004670118; https://doi.org/10.1073/pnas.2004670118
Sustainability Science
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  The decline of mammal functional and evolutionary diversity worldwide
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  PNAS January 19, 2021 118 (3) e1921849118; https://doi.org/10.1073/pnas.1921849118
Systems Biology
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  Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms
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  PNAS January 19, 2021 118 (3) e2015803118; https://doi.org/10.1073/pnas.2015803118

Correction

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Correction for Silva et al., Repurposing a peptide toxin from wasp venom into antiinfectives with dual antimicrobial and immunomodulatory properties
PNAS January 19, 2021 118 (3) e2025351118; https://doi.org/10.1073/pnas.2025351118

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