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Research Article

Tornado-inspired acoustic vortex tweezer for trapping and manipulating microbubbles

Wei-Chen Lo, View ORCID ProfileChing-Hsiang Fan, Yi-Ju Ho, Chia-Wei Lin, and Chih-Kuang Yeh
  1. aDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, 30013 Taiwan;
  2. bDepartment of Biomedical Engineering, National Cheng Kung University, Tainan, 701 Taiwan;
  3. cMedical Device Innovation Center, National Cheng Kung University, Tainan, 701 Taiwan;
  4. dInstitute of Nuclear Engineering and Sciences, National Tsing Hua University, Hsinchu, 30013 Taiwan

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PNAS January 26, 2021 118 (4) e2023188118; https://doi.org/10.1073/pnas.2023188118
Wei-Chen Lo
aDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, 30013 Taiwan;
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Ching-Hsiang Fan
bDepartment of Biomedical Engineering, National Cheng Kung University, Tainan, 701 Taiwan;
cMedical Device Innovation Center, National Cheng Kung University, Tainan, 701 Taiwan;
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  • ORCID record for Ching-Hsiang Fan
Yi-Ju Ho
aDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, 30013 Taiwan;
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Chia-Wei Lin
aDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, 30013 Taiwan;
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Chih-Kuang Yeh
aDepartment of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, 30013 Taiwan;
dInstitute of Nuclear Engineering and Sciences, National Tsing Hua University, Hsinchu, 30013 Taiwan
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  • For correspondence: ckyeh@mx.nthu.edu.tw
  1. Edited by Robert Langer, Massachusetts Institute of Technology, Cambridge, MA, and approved December 9, 2020 (received for review November 17, 2020)

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Data supplements

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    • Download Appendix (PDF)
    • Download Movie_S01 (AVI) - Upon initiating the trapping, the aggregated MBs swirled around and ultimately became trapped in the center, thereby forming an MB cluster. Video is played at 15 fps.
    • Download Movie_S02 (AVI) - Series of side-view images showing that MBs initially experience the radiation force pushing on the wall and then the trapping force that immediately collects the dispersed clusters into the center of the AVT focal zone. Video is played at 15 fps.
    • Download Movie_S03 (AVI) - Zoomed-out view showing the formation of an upstream MB cluster during AVT initiation, which finally results in trapping failure. Video is played at 15 fps.
    • Download Movie_S04 (AVI) - The independent motion in the x and y directions by trapped MBs at a flow velocity of 2.6 cm/s. Video is played at 15 fps.
    • Download Movie_S05 (AVI) - Comparisons of AVT trapping in the presence of a mixture of MBs and pure blood in the static condition. Video is played at 15 fps.
    • Download Movie_S06 (AVI) - Comparisons of AVT trapping in the presence of a mixture of MBs and pure blood with flow velocity of 2.6 cm/s. Video is played at 15 fps.
    • Download Movie_S07 (AVI) - MB aggregation occurred when the AVT were trapping in vivo. Video is played at 15 fps.
    • Download Movie_S08 (AVI) - The MB cluster could be transversely moved from the centerline of the vessel to the vessel endothelium by adjusting the position of either the animal or the AVT transducer. Video is played at 15 fps.
    • Download Movie_S09 (AVI) - Although inflowing MBs accumulated upstream of the trapping zone, they started to disperse after passing the trapping zone. Video is played at 15 fps.
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Tornado-inspired acoustic vortex tweezer for trapping and manipulating microbubbles
Wei-Chen Lo, Ching-Hsiang Fan, Yi-Ju Ho, Chia-Wei Lin, Chih-Kuang Yeh
Proceedings of the National Academy of Sciences Jan 2021, 118 (4) e2023188118; DOI: 10.1073/pnas.2023188118

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Tornado-inspired acoustic vortex tweezer for trapping and manipulating microbubbles
Wei-Chen Lo, Ching-Hsiang Fan, Yi-Ju Ho, Chia-Wei Lin, Chih-Kuang Yeh
Proceedings of the National Academy of Sciences Jan 2021, 118 (4) e2023188118; DOI: 10.1073/pnas.2023188118
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Proceedings of the National Academy of Sciences: 118 (4)
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