Better explicating the strengths and shortcomings of these models will help refine projections and improve transparency in the years ahead.
Image credit: Witsawat.S.
Understanding whether genetic drift or natural selection is responsible for the phenotypic difference between two strains is a major goal of evolutionary biology. Building on Orr’s quantitative trait locus (QTL) sign test (1), Fraser developed a clever test of phenotypic selection that requires only a genetic cross between the two strains followed by phenotyping of these strains and their F2 progenies (2). The simplicity of this test makes it applicable to a wide variety of traits of many species. Here we draw attention to two caveats.
That we are investigating the role of natural selection in the divergence of a trait between two strains, S1 and …
↵1To whom correspondence may be addressed. Email: jianzhi{at}umich.edu.
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Caution in testing phenotypic selection
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