Modulating the body's networks could become mainstream therapy for many health issues.
Image credit: The Feinstein Institutes for Medicine Research.
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Abstract
The incubation of purified ribosomes with colicin E3 results in the cleavage of a terminal fragment from the 16S ribosomal RNA. The cleavage reaction requires three components: colicin E3, the 30S ribosomal subunit, and the 50S ribosomal subunit. An immunity factor found in extracts derived from colicinogenic cells prevents the in vitro inactivation of ribosomes by colicin E3. Evidence is presented suggesting that it does so by binding to the colicin molecule. The mode of action of colicin E3in vivo can be explained by the assumption that a small fraction of the adsorbed colicin penetrates into the cell and catalytically inactivates the ribosomes.
Inactivation of Ribosomes In Vitro by Colicin E3 and Its Mechanism of Action
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