Scientists should pursue a strategic approach to research, focusing on the accumulation of evidence via designed sequences of studies.
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Abstract
The synthesis and evaluation of a new detergent that is a zwitterionic derivative of cholic acid is presented. This detergent combines the useful properties of both the sulfobetaine-type detergents and the bile salt anions. The new detergent proved to be effective at solubilizing membrane proteins in a nondenatured state.
A nondenaturing zwitterionic detergent for membrane biochemistry: design and synthesis
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