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Research Article

A model for the RNA-catalyzed replication of RNA

T R Cech
PNAS June 1, 1986 83 (12) 4360-4363; https://doi.org/10.1073/pnas.83.12.4360
T R Cech
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Abstract

A shortened form of the self-splicing ribosomal RNA intervening sequence of Tetrahymena thermophila has enzymatic activity as a poly(cytidylic acid) polymerase [Zaug, A.J. & Cech, T.R. (1986) Science 231, 470-475]. Based on the known properties of this enzyme, a detailed model is developed for the template-dependent synthesis of RNA by an RNA polymerase itself made of RNA. The monomer units for RNA synthesis are tetra- and pentanucleotides of random base sequence. Polymerization occurs in a 5'-to-3' direction, and elongation rates are expected to approach two residues per minute. If the RNA enzyme could use another copy of itself as a template, RNA self-replication could be achieved. Thus, it seems possible that RNA catalysts might have played a part in prebiotic nucleic acid replication, prior to the availability of useful proteins.

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A model for the RNA-catalyzed replication of RNA
T R Cech
Proceedings of the National Academy of Sciences Jun 1986, 83 (12) 4360-4363; DOI: 10.1073/pnas.83.12.4360

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A model for the RNA-catalyzed replication of RNA
T R Cech
Proceedings of the National Academy of Sciences Jun 1986, 83 (12) 4360-4363; DOI: 10.1073/pnas.83.12.4360
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