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Research Article

Tissue-specific regulatory differences for the alcohol dehydrogenase genes of Hawaiian Drosophila are conserved in Drosophila melanogaster transformants

M D Brennan, C Y Wu, and A J Berry
PNAS September 1, 1988 85 (18) 6866-6869; https://doi.org/10.1073/pnas.85.18.6866
M D Brennan
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C Y Wu
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A J Berry
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Abstract

Naturally occurring regulatory variation is a source of genetic variability that is well documented but poorly understood. Two members of the Hawaiian picture-winged Drosophila, D. affinidisjuncta and D. hawaiiensis, display markedly different levels of alcohol dehydrogenase (alcohol: NAD+ oxidoreductase, EC 1.1.1.1) in the larval midgut and Malpighian tubules. To analyze the regulation of the alcohol dehydrogenase genes from these two species, their homologous alcohol dehydrogenase genes were cloned and introduced, via P element-mediated transformation, into the germ line of Drosophila melanogaster. Histochemical and electrophoretic analyses of larval transformants demonstrate that major differences in the tissue-specific levels of alcohol dehydrogenase production are characteristic of the alcohol dehydrogenase genes themselves. While these results do not directly address possible species-specific differences in the tissue distribution of trans-acting regulatory components, they indicate that demonstrable differences in cis-dominant regulatory information are sufficient to account for the observed regulatory variation.

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Tissue-specific regulatory differences for the alcohol dehydrogenase genes of Hawaiian Drosophila are conserved in Drosophila melanogaster transformants
M D Brennan, C Y Wu, A J Berry
Proceedings of the National Academy of Sciences Sep 1988, 85 (18) 6866-6869; DOI: 10.1073/pnas.85.18.6866

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Tissue-specific regulatory differences for the alcohol dehydrogenase genes of Hawaiian Drosophila are conserved in Drosophila melanogaster transformants
M D Brennan, C Y Wu, A J Berry
Proceedings of the National Academy of Sciences Sep 1988, 85 (18) 6866-6869; DOI: 10.1073/pnas.85.18.6866
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