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Research Article

Origin of human chromosome 2: an ancestral telomere-telomere fusion.

J W IJdo, A Baldini, D C Ward, S T Reeders, and R A Wells
  1. Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510.

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PNAS October 15, 1991 88 (20) 9051-9055; https://doi.org/10.1073/pnas.88.20.9051
J W IJdo
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510.
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A Baldini
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510.
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D C Ward
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510.
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S T Reeders
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510.
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R A Wells
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510.
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Abstract

We have identified two allelic genomic cosmids from human chromosome 2, c8.1 and c29B, each containing two inverted arrays of the vertebrate telomeric repeat in a head-to-head arrangement, 5'(TTAGGG)n-(CCCTAA)m3'. Sequences flanking this telomeric repeat are characteristic of present-day human pretelomeres. BAL-31 nuclease experiments with yeast artificial chromosome clones of human telomeres and fluorescence in situ hybridization reveal that sequences flanking these inverted repeats hybridize both to band 2q13 and to different, but overlapping, subsets of human chromosome ends. We conclude that the locus cloned in cosmids c8.1 and c29B is the relic of an ancient telomere-telomere fusion and marks the point at which two ancestral ape chromosomes fused to give rise to human chromosome 2.

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Origin of human chromosome 2: an ancestral telomere-telomere fusion.
J W IJdo, A Baldini, D C Ward, S T Reeders, R A Wells
Proceedings of the National Academy of Sciences Oct 1991, 88 (20) 9051-9055; DOI: 10.1073/pnas.88.20.9051

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Origin of human chromosome 2: an ancestral telomere-telomere fusion.
J W IJdo, A Baldini, D C Ward, S T Reeders, R A Wells
Proceedings of the National Academy of Sciences Oct 1991, 88 (20) 9051-9055; DOI: 10.1073/pnas.88.20.9051
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