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Research Article

Evidence for virus-encoded glycosylation specificity.

I N Wang, Y Li, Q Que, M Bhattacharya, L C Lane, W G Chaney, and J L Van Etten
PNAS May 1, 1993 90 (9) 3840-3844; https://doi.org/10.1073/pnas.90.9.3840
I N Wang
Department of Plant Pathology, University of Nebraska, Lincoln 68583-0722.
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Y Li
Department of Plant Pathology, University of Nebraska, Lincoln 68583-0722.
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Q Que
Department of Plant Pathology, University of Nebraska, Lincoln 68583-0722.
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M Bhattacharya
Department of Plant Pathology, University of Nebraska, Lincoln 68583-0722.
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L C Lane
Department of Plant Pathology, University of Nebraska, Lincoln 68583-0722.
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W G Chaney
Department of Plant Pathology, University of Nebraska, Lincoln 68583-0722.
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J L Van Etten
Department of Plant Pathology, University of Nebraska, Lincoln 68583-0722.
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Abstract

Four spontaneously derived serologically distinct classes of mutants of the Paramecium bursaria chlorella virus (PBCV-1) were isolated using polyclonal antiserum prepared against either intact PBCV-1 or PBCV-1-derived serotypes. The oligosaccharide(s) of the viral major capsid protein and two minor glycoproteins determined virus serological specificity. Normally, viral glycoproteins arise from host-specific glycosylation of viral proteins; the glycan portion can be altered only by growing the virus on another host or by mutations in glycosylation sites of the viral protein. Neither mechanism explains the changes in the glycan(s) of the PBCV-1 major capsid protein because all of the viruses were grown in the same host alga and the predicted amino acid sequence of the major capsid protein was identical in the PBCV-1 serotypes. PBCV-1 antiserum resistance is best explained by viral mutations that block specific steps in glycosylation, possibly by inactivating glycosyltransferases.

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Evidence for virus-encoded glycosylation specificity.
I N Wang, Y Li, Q Que, M Bhattacharya, L C Lane, W G Chaney, J L Van Etten
Proceedings of the National Academy of Sciences May 1993, 90 (9) 3840-3844; DOI: 10.1073/pnas.90.9.3840

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Evidence for virus-encoded glycosylation specificity.
I N Wang, Y Li, Q Que, M Bhattacharya, L C Lane, W G Chaney, J L Van Etten
Proceedings of the National Academy of Sciences May 1993, 90 (9) 3840-3844; DOI: 10.1073/pnas.90.9.3840
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