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Research Article

Interleukin 2 (IL-2) and interleukin 7 (IL-7) reciprocally induce IL-7 and IL-2 receptors on gamma delta T-cell receptor-positive intraepithelial lymphocytes

K Fujihashi, S Kawabata, T Hiroi, M Yamamoto, J R McGhee, S Nishikawa, and H Kiyono
  1. Department of Oral Biology, University of Alabama at Birmingham Medical Center, AL 35294, USA.

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PNAS April 16, 1996 93 (8) 3613-3618; https://doi.org/10.1073/pnas.93.8.3613
K Fujihashi
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S Kawabata
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T Hiroi
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M Yamamoto
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J R McGhee
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S Nishikawa
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H Kiyono
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Abstract

In this study, we describe the interaction between cytokine and cytokine receptor (R) for the activation and proliferation of gamma delta T-cell receptor-positive T cells (gamma delta T cells). gamma delta T cells isolated from murine intestinal intraepithelial lymphocytes (IELs) were separated into gamma delta (Dim) and gamma delta (Bright) fractions according to the intensity of gamma delta T-cell receptor expression. The gamma delta T cells express low levels of IL-2R and IL-7R as shown by flow cytometry and reverse transcriptase-PCR analysis, whereas gamma delta (Bright) T cells did not express either receptor. Our study also revealed that recombinant marine (rm)IL-2 and rmIL-7 reciprocally induced high expressions of IL-7R and IL-2R, respectively, on gamma delta (Dim) T cells but not on gamma delta (Bright) cells. Thus, treatment of gamma delta (Dim) T cells with rmIL-2 and rmIL-7 resulted in high proliferative responses, whereas gamma delta (Bright) T cells did not respond to these two cytokines. The sources of these two cytokines for gamma delta T cells were neighboring epithelial cells (IL-7) and alpha beta T cells (IL-2 and IL-7). Cytokine signaling by IL-2 and IL-7 from alpha beta T cells and epithelial cells was necessary for the expression of IL-7R and IL-2R, respectively, on a subset of gamma delta T cells (e.g., gamma delta (Dim) T cells) in mucosa-associated tissue for subsequent activation and cell division.

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Interleukin 2 (IL-2) and interleukin 7 (IL-7) reciprocally induce IL-7 and IL-2 receptors on gamma delta T-cell receptor-positive intraepithelial lymphocytes
K Fujihashi, S Kawabata, T Hiroi, M Yamamoto, J R McGhee, S Nishikawa, H Kiyono
Proceedings of the National Academy of Sciences Apr 1996, 93 (8) 3613-3618; DOI: 10.1073/pnas.93.8.3613

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Interleukin 2 (IL-2) and interleukin 7 (IL-7) reciprocally induce IL-7 and IL-2 receptors on gamma delta T-cell receptor-positive intraepithelial lymphocytes
K Fujihashi, S Kawabata, T Hiroi, M Yamamoto, J R McGhee, S Nishikawa, H Kiyono
Proceedings of the National Academy of Sciences Apr 1996, 93 (8) 3613-3618; DOI: 10.1073/pnas.93.8.3613
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