Ecteinascidin 743, a transcription-targeted chemotherapeutic that inhibits MDR1 activation

Shengkan Jin; Barbara Gorfajn; Glynn Faircloth; Kathleen W. Scotto

doi:10.1073/pnas.97.12.6775

Edited by Samuel J. Danishefsky, Memorial Sloan–Kettering Cancer Center, New York, NY, and approved April 3, 2000 (received for review November 29, 1999)

Online Impact

Article Information

vol. 97 no. 12 6775-6779

DOI:

https://doi.org/10.1073/pnas.97.12.6775

PubMed:

10841572

Published By:

National Academy of Sciences

Print ISSN:

0027-8424

Online ISSN:

1091-6490

History:

Received November 29, 1999
Published June 6, 2000.

Author Information

Shengkan Jin*,
Barbara Gorfajn*,
Glynn Faircloth†, and
Kathleen W. Scotto*‡

^*Molecular Pharmacology and Therapeutics Program, Memorial Sloan–Kettering Cancer Center and the Weill Graduate School of Medical Sciences of Cornell University, 1275 York Avenue, New York, NY 10021; and ^†PharmaMar USA, 320 Putnam Avenue, Cambridge, MA 02139

Edited by Samuel J. Danishefsky, Memorial Sloan–Kettering Cancer Center, New York, NY, and approved April 3, 2000 (received for review November 29, 1999)

Footnotes

↵‡ To whom reprint requests should be addressed. E-mail: k-scotto{at}ski.mskcc.org.
This paper was submitted directly (Track II) to the PNAS office.

Cited By...

Article usage

Article usage: June 2000 to April 2021

	Abstract	Full	Pdf
Jun 2000	130	116	179
Jul 2000	25	56	54
Aug 2000	11	46	58
Sep 2000	7	43	52
Oct 2000	7	45	46
Nov 2000	7	47	39
Dec 2000	3	33	32
Total 2000	190	386	460
Jan 2001	13	35	36
Feb 2001	12	39	40
Mar 2001	11	31	32
Apr 2001	11	31	32
May 2001	1	30	47
Jun 2001	2	20	29
Jul 2001	2	23	30
Aug 2001	2	21	29
Sep 2001	7	28	28
Oct 2001	7	29	46
Nov 2001	4	30	42
Dec 2001	2	17	25
Total 2001	74	334	416
Jan 2002	4	29	37
Feb 2002	2	23	20
Mar 2002	2	23	34
Apr 2002	3	24	33
May 2002	5	20	17
Jun 2002	12	26	24
Jul 2002	8	13	12
Aug 2002	0	18	11
Sep 2002	6	18	15
Oct 2002	2	14	21
Nov 2002	0	16	24
Dec 2002	3	11	22
Total 2002	47	235	270
Jan 2003	9	18	21
Feb 2003	1	8	10
Mar 2003	1	13	10
Apr 2003	2	14	18
May 2003	2	15	15
Jun 2003	7	14	16
Jul 2003	12	19	12
Aug 2003	17	20	38
Sep 2003	16	23	25
Oct 2003	16	29	22
Nov 2003	26	22	33
Dec 2003	22	28	25
Total 2003	131	223	245
Jan 2004	17	22	25
Feb 2004	12	29	22
Mar 2004	12	26	40
Apr 2004	11	17	35
May 2004	18	17	22
Jun 2004	16	26	13
Jul 2004	20	19	5
Aug 2004	20	17	11
Sep 2004	27	23	17
Oct 2004	19	19	18
Nov 2004	29	47	36
Dec 2004	24	16	9
Total 2004	225	278	253
Jan 2005	22	26	18
Feb 2005	9	13	11
Mar 2005	6	17	36
Apr 2005	6	15	21
May 2005	9	15	19
Jun 2005	10	10	11
Jul 2005	7	7	3
Aug 2005	5	13	18
Sep 2005	23	13	18
Oct 2005	20	14	6
Nov 2005	15	23	21
Dec 2005	16	14	18
Total 2005	148	180	200
Jan 2006	16	19	16
Feb 2006	26	26	19
Mar 2006	9	14	15
Apr 2006	20	21	11
May 2006	15	11	7
Jun 2006	12	17	15
Jul 2006	16	6	8
Aug 2006	10	6	9
Sep 2006	13	15	8
Oct 2006	21	16	16
Nov 2006	17	16	15
Dec 2006	25	21	6
Total 2006	200	188	145
Jan 2007	14	24	15
Feb 2007	18	15	17
Mar 2007	14	21	12
Apr 2007	10	23	12
May 2007	4	7	9
Jun 2007	3	4	9
Jul 2007	7	6	6
Aug 2007	10	13	2
Sep 2007	3	5	7
Oct 2007	11	14	12
Nov 2007	12	7	6
Dec 2007	4	16	7
Total 2007	110	155	114
Jan 2008	15	7	8
Feb 2008	9	14	10
Mar 2008	10	19	14
Apr 2008	15	18	14
May 2008	16	8	7
Jun 2008	17	3	11
Jul 2008	28	7	6
Aug 2008	19	6	2
Sep 2008	17	1	7
Oct 2008	16	4	7
Nov 2008	22	8	5
Dec 2008	8	4	4
Total 2008	192	99	95
Jan 2009	29	6	20
Feb 2009	26	9	10
Mar 2009	15	9	5
Apr 2009	30	10	13
May 2009	14	12	6
Jun 2009	12	6	5
Jul 2009	15	8	5
Aug 2009	12	8	6
Sep 2009	20	4	3
Oct 2009	22	12	12
Nov 2009	18	3	7
Dec 2009	15	8	8
Total 2009	228	95	100
Jan 2010	11	4	5
Feb 2010	20	12	16
Mar 2010	12	13	8
Apr 2010	14	11	8
May 2010	14	7	6
Jun 2010	10	1	3
Jul 2010	11	10	4
Aug 2010	10	3	5
Sep 2010	10	5	4
Oct 2010	12	9	11
Nov 2010	20	15	11
Dec 2010	9	6	4
Total 2010	153	96	85
Jan 2011	8	10	4
Feb 2011	3	6	6
Mar 2011	14	9	9
Apr 2011	7	7	9
May 2011	11	3	6
Jun 2011	8	17	7
Jul 2011	66	6	11
Aug 2011	68	5	9
Sep 2011	99	8	5
Oct 2011	84	6	4
Nov 2011	89	6	3
Dec 2011	153	4	6
Total 2011	610	87	79
Jan 2012	94	1	4
Feb 2012	64	7	2
Mar 2012	99	3	7
Apr 2012	90	12	12
May 2012	92	4	4
Jun 2012	54	3	4
Jul 2012	75	3	10
Aug 2012	97	2	6
Sep 2012	32	0	5
Oct 2012	44	5	5
Nov 2012	68	1	5
Dec 2012	80	4	12
Total 2012	889	45	76
Jan 2013	103	6	6
Feb 2013	73	5	6
Mar 2013	85	3	10
Apr 2013	85	11	5
May 2013	94	6	5
Jun 2013	99	32	2
Jul 2013	83	10	1
Aug 2013	98	5	8
Sep 2013	58	4	6
Oct 2013	70	7	5
Nov 2013	48	6	6
Dec 2013	48	7	7
Total 2013	944	102	67
Jan 2014	62	4	16
Feb 2014	41	15	7
Mar 2014	65	3	12
Apr 2014	83	30	4
May 2014	34	3	9
Jun 2014	54	1	13
Jul 2014	94	4	4
Aug 2014	82	10	2
Sep 2014	77	11	6
Oct 2014	60	14	8
Nov 2014	49	10	8
Dec 2014	63	2	4
Total 2014	764	107	93
Jan 2015	57	5	1
Feb 2015	40	5	3
Mar 2015	60	3	7
Apr 2015	54	2	3
May 2015	47	3	5
Jun 2015	39	5	9
Jul 2015	39	18	9
Aug 2015	34	10	6
Sep 2015	92	5	2
Oct 2015	50	13	11
Nov 2015	29	20	10
Dec 2015	43	53	7
Total 2015	584	142	73
Jan 2016	46	106	7
Feb 2016	31	114	5
Mar 2016	26	115	10
Apr 2016	46	4	3
May 2016	36	4	3
Jun 2016	35	5	6
Jul 2016	25	10	6
Aug 2016	36	26	5
Sep 2016	50	9	7
Oct 2016	29	4	3
Nov 2016	39	15	1
Dec 2016	44	7	4
Total 2016	443	419	60
Jan 2017	37	5	9
Feb 2017	41	3	5
Mar 2017	44	8	6
Apr 2017	18	5	3
May 2017	25	3	1
Jun 2017	39	3	5
Jul 2017	63	7	12
Aug 2017	30	2	1
Sep 2017	24	6	6
Oct 2017	32	7	7
Nov 2017	15	7	6
Dec 2017	30	5	2
Total 2017	398	61	63
Jan 2018	15	1	0
Feb 2018	8	9	5
Mar 2018	15	14	4
Apr 2018	11	13	4
May 2018	23	27	6
Jun 2018	18	22	3
Jul 2018	11	12	1
Aug 2018	19	19	5
Sep 2018	16	17	3
Oct 2018	3	17	3
Nov 2018	4	28	6
Dec 2018	2	32	8
Total 2018	145	211	48
Jan 2019	6	12	3
Feb 2019	2	16	3
Mar 2019	3	11	4
Apr 2019	0	18	3
May 2019	2	15	3
Jun 2019	6	6	3
Jul 2019	0	8	4
Aug 2019	1	10	10
Sep 2019	2	41	4
Oct 2019	7	23	8
Nov 2019	3	11	7
Dec 2019	0	12	6
Total 2019	32	183	58
Jan 2020	2	8	0
Feb 2020	3	4	2
Mar 2020	2	6	2
Apr 2020	0	8	3
May 2020	0	10	1
Jun 2020	2	7	4
Jul 2020	0	11	2
Aug 2020	1	6	3
Sep 2020	1	22	1
Oct 2020	6	16	8
Nov 2020	2	21	5
Dec 2020	5	21	2
Total 2020	24	140	33
Jan 2021	6	15	7
Feb 2021	1	16	6
Mar 2021	3	17	2
Apr 2021	2	9	1
Total 2021	12	57	16
Total	6543	3823	3049