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Table of Contents
August 01, 2000; vol. 97 no. 16
Colloquium Papers (free online)
- You have accessPathogens and hosts: The dance is the same, the couples are differentNoel Keen, Brian Staskawicz, John Mekalanos, Frederick Ausubel, and R. James Cook
- You have accessStriking a balance: Modulation of the actin cytoskeleton by SalmonellaJorge E. Galán and Daoguo Zhou
- You have accessStructure and function of pectic enzymes: Virulence factors of plant pathogensSteven R. Herron, Jacques A. E. Benen, Robert D. Scavetta, Jaap Visser, and Frances Jurnak
- You have accessPseudomonas syringae Hrp type III secretion system and effector proteinsAlan Collmer, Jorge L. Badel, Amy O. Charkowski, Wen-Ling Deng, Derrick E. Fouts, Adela R. Ramos, Amos H. Rehm, Deborah M. Anderson, Olaf Schneewind, Karin van Dijk, and James R. Alfano
- You have accessA framework for interpreting the leucine-rich repeats of the Listeria internalinsMichael Marino, Laurence Braun, Pascale Cossart, and Partho Ghosh
- You have accessAcyl-homoserine lactone quorum sensing in Gram-negative bacteria: A signaling mechanism involved in associations with higher organismsMatthew R. Parsek and E. Peter Greenberg
- You have accessPhenotypic variation and intracellular parasitism by Histoplasma capsulatumSilke Kügler, Tricia Schurtz Sebghati, Linda Groppe Eissenberg, and William E. Goldman
- You have accessExploitation of host cells by enteropathogenic Escherichia coliB. A. Vallance and B. B. Finlay
- You have accessGenetic complexity of pathogen perception by plants: The example of Rcr3, a tomato gene required specifically by Cf-2Mark S. Dixon, Catherine Golstein, Colwyn M. Thomas, Erik A. van der Biezen, and Jonathan D. G. Jones
- You have accessPlants and animals share functionally common bacterial virulence factorsLaurence G. Rahme, Frederick M. Ausubel, Hui Cao, Eliana Drenkard, Boyan C. Goumnerov, Gee W. Lau, Shalina Mahajan-Miklos, Julia Plotnikova, Man-Wah Tan, John Tsongalis, Cynthia L. Walendziewicz, and Ronald G. Tompkins
- You have accessRole of the cystic fibrosis transmembrane conductance regulator in innate immunity to Pseudomonas aeruginosa infectionsGerald B. Pier
- You have accessBad bugs and beleaguered bladders: Interplay between uropathogenic Escherichia coli and innate host defensesMatthew A. Mulvey, Joel D. Schilling, Juan J. Martinez, and Scott J. Hultgren
- You have accessAvrPto-dependent Pto-interacting proteins and AvrPto-interacting proteins in tomatoAdam J. Bogdanove and Gregory B. Martin
- You have accessReactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogensCarl Nathan and Michael U. Shiloh
- You have accessNitric oxide and salicylic acid signaling in plant defenseDaniel F. Klessig, Jörg Durner, Robert Noad, Duroy A. Navarre, David Wendehenne, Dhirendra Kumar, Jun Ma Zhou, Jyoti Shah, Shuqun Zhang, Pradeep Kachroo, Youssef Trifa, Dominique Pontier, Eric Lam, and Herman Silva
- You have accessThe role of antimicrobial peptides in animal defensesRobert E. W. Hancock and Monisha G. Scott
- You have accessSuramin inhibits initiation of defense signaling by systemin, chitosan, and a β-glucan elicitor in suspension-cultured Lycopersicon peruvianum cellsJohannes Stratmann, Justin Scheer, and Clarence A. Ryan
Physical Sciences
Chemistry
- You have accessSpeeding molecular recognition by using the folding funnel: The fly-casting mechanismBenjamin A. Shoemaker, John J. Portman, and Peter G. Wolynes
- You have accessToward elimination of discrepancies between theory and experiment: The rate constant of the atmospheric conversion of SO3 to H2SO4Thomas Loerting and Klaus R. Liedl
- You have accessInformation theory, atoms in molecules, and molecular similarityRoman F. Nalewajski and Robert G. Parr
Engineering
- You have accessPositron emission tomography provides molecular imaging of biological processes
- Inaugural Article
Michael E. Phelps
Social Sciences
Social Sciences
- You have accessA dynamic model of social network formation
- Inaugural Article
Brian Skyrms and Robin Pemantle
Biological Sciences
Biochemistry
- You have accessThe N terminus of microsomal Δ9 stearoyl-CoA desaturase contains the sequence determinant for its rapid degradationHassan Mziaut, George Korza, and Juris Ozols
- You have accessA new role for a SNARE protein as a regulator of the Ypt7/Rab-dependent stage of dockingChristian Ungermann, Albert Price, and William Wickner
- You have accessProtein binding and unfolding by the chaperone ClpA and degradation by the protease ClpAPJoel R. Hoskins, Satyendra K. Singh, Michael R. Maurizi, and Sue Wickner
- You have accessUnfolding and internalization of proteins by the ATP-dependent proteases ClpXP and ClpAPSatyendra K. Singh, Regis Grimaud, Joel R. Hoskins, Sue Wickner, and Michael R. Maurizi
- You have accessMouse Sebox homeobox gene expression in skin, brain, oocytes, and two-cell embryosMario Cinquanta, Alessandra C. Rovescalli, Christine A. Kozak, and Marshall Nirenberg
- You have accessMyotubularin, a protein tyrosine phosphatase mutated in myotubular myopathy, dephosphorylates the lipid second messenger, phosphatidylinositol 3-phosphate
- Inaugural Article
Gregory S. Taylor, Tomohiko Maehama, and Jack E. Dixon - You have accessHydrolytic editing by a class II aminoacyl-tRNA synthetasePenny J. Beuning and Karin Musier-Forsyth
- You have accessThe molecular basis of vancomycin resistance in clinically relevant Enterococci: Crystal structure of d-alanyl-d-lactate ligase (VanA)David I. Roper, Trevor Huyton, Alexei Vagin, and Guy Dodson
- You have accessBacterial-type DNA Holliday junction resolvases in eukaryotic virusesAlonzo D. Garcia, L. Aravind, Eugene V. Koonin, and Bernard Moss
See companion article:
- Resolving the relationships of resolving enzymes- Aug 15, 2000
- You have accessCrystal structure of Escherichia coli CyaY protein reveals a previously unidentified fold for the evolutionarily conserved frataxin familySeung-Je Cho, Myong Gyong Lee, Jin Kuk Yang, Jae Young Lee, Hyun Kyu Song, and Se Won Suh
- You have accessThe central cytoplasmic loop of the major facilitator superfamily of transport proteins governs efficient membrane insertionAdam B. Weinglass and H. Ronald Kaback
- You have accessRapid mapping of protein functional epitopes by combinatorial alanine scanningGregory A. Weiss, Colin K. Watanabe, Alan Zhong, Audrey Goddard, and Sachdev S. Sidhu
- You have accessRibozyme-mediated inhibition of HIV 1 suggests nucleolar trafficking of HIV-1 RNAAlessandro Michienzi, Laurence Cagnon, Ingrid Bahner, and John J. Rossi
- You have accessThe spliceosomal snRNP core complex of Trypanosoma brucei: Cloning and functional analysis reveals seven Sm protein constituentsZsofia Palfi, Stephan Lücke, Hans-Werner Lahm, William S. Lane, Volker Kruft, Elisabeth Bragado-Nilsson, Bertrand Séraphin, and Albrecht Bindereif
- You have accessThe RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complexMichael Gmachl, Christian Gieffers, Alexandre V. Podtelejnikov, Matthias Mann, and Jan-Michael Peters
- You have accessA systematic exploration of the influence of the protein stability on amyloid fibril formation in vitroMarina Ramírez-Alvarado, Jane S. Merkel, and Lynne Regan
- You have accessHormone binding induces rapid proteasome-mediated degradation of thyroid hormone receptorsAlexandra Dace, Li Zhao, Kyung Soo Park, T. Furuno, N. Takamura, M. Nakanishi, Brian L. West, John A. Hanover, and Sheue-yann Cheng
- You have accessA dual role for the kinase-like domain of the tyrosine kinase Tyk2 in interferon-α signalingTammie C. Yeh, Elisabetta Dondi, Gilles Uzé, and Sandra Pellegrini
- You have accessBarrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein complexRonglan Zheng, Rodolfo Ghirlando, Myung Soo Lee, Kiyoshi Mizuuchi, Michael Krause, and Robert Craigie
- You have accessHigh-frequency intrachromosomal gene conversion induced by triplex-forming oligonucleotides microinjected into mouse cellsZhongjun Luo, Margaret A. Macris, A. Fawad Faruqi, and Peter M. Glazer
- You have accessThe cysteine desulfurase, IscS, has a major role in in vivo Fe-S cluster formation in Escherichia coliChristopher J. Schwartz, Ouliana Djaman, James A. Imlay, and Patricia J. Kiley
- You have accessProtein-interaction modules that organize nuclear function: FF domains of CA150 bind the phosphoCTD of RNA polymerase IISherry M. Carty, Aaron C. Goldstrohm, Carles Suñé, Mariano A. Garcia-Blanco, and Arno L. Greenleaf
Biophysics
- You have accessSpeeding molecular recognition by using the folding funnel: The fly-casting mechanismBenjamin A. Shoemaker, John J. Portman, and Peter G. Wolynes
- You have accessEnergetics of the HIV gp120-CD4 binding reactionDavid G. Myszka, Raymond W. Sweet, Preston Hensley, Michael Brigham-Burke, Peter D. Kwong, Wayne A. Hendrickson, Richard Wyatt, Joseph Sodroski, and Michael L. Doyle
- You have accessModulation of CTP:phosphocholine cytidylyltransferase by membrane curvature elastic stressGeorge S. Attard, Richard H. Templer, Wendy S. Smith, Alan N. Hunt, and Suzanne Jackowski
- You have accessKinetic and thermodynamic control of protein adsorptionJ. Satulovsky, M. A. Carignano, and I. Szleifer
Cell Biology
- You have accessDown-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cellsSandrine Cariou, Jeffrey C. H. Donovan, W. M. Flanagan, Andrea Milic, Nandita Bhattacharya, and Joyce M. Slingerland
- You have accessRecognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting proteinJoke G. Orsel, Paul M. Sincock, Jeffrey P. Krise, and Suzanne R. Pfeffer
- You have accessThe NF-κB signal transduction pathway in aortic endothelial cells is primed for activation in regions predisposed to atherosclerotic lesion formationLeena Hajra, Andrew I. Evans, Mian Chen, Sharon J. Hyduk, Tucker Collins, and Myron I. Cybulsky
- You have accessMolecular basis of protein kinase C-induced activation of ATP-sensitive potassium channelsPeter E. Light, Christopher Bladen, Robert J. Winkfein, Michael P. Walsh, and Robert J. French
- You have accessThe junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilinBenjamin Boettner, Eve-Ellen Govek, Justin Cross, and Linda Van Aelst
- You have accessNeisseria meningitidis porin PorB interacts with mitochondria and protects cells from apoptosisPaola Massari, Yu Ho, and Lee M. Wetzler
- You have accessPaxillin α and Crk-associated substrate exert opposing effects on cell migration and contact inhibition of growth through tyrosine phosphorylationHajime Yano, Hiroshi Uchida, Teruo Iwasaki, Mutsuko Mukai, Hitoshi Akedo, Kuniaki Nakamura, Shigeru Hashimoto, and Hisataka Sabe
- You have accessExpression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxiaRichard K. Bruick
- You have accessTranscription-coupled repair in yeast is independent from ubiquitylation of RNA pol II: Implications for Cockayne's syndromeLori Lommel, Miriam E. Bucheli, and Kevin S. Sweder
Developmental Biology
- You have accessGastrulation Defective is a serine protease involved in activating the receptor Toll to polarize the Drosophila embryoJin-Hua Han, Si Hyoung Lee, Yue-Qing Tan, Ellen K. LeMosy, and Carl Hashimoto
- You have accessSpatial control of cell differentiation in Myxococcus xanthusBryan Julien, A. Dale Kaiser, and Anthony Garza
- You have accessPlacental expression of the nonclassical MHC class I molecule Mamu-AG at implantation in the rhesus monkeyI. I. Slukvin, D. P. Lunn, D. I. Watkins, and T. G. Golos
Evolution
- You have accessArtificial ecosystem selection
- From the Cover
William Swenson, David Sloan Wilson, and Roberta EliasSee companion article:
- Heritability at the ecosystem level- Aug 15, 2000
- You have accessEvolutionary consequences of changes in species' geographical distributions driven by Milankovitch climate oscillationsMats Dynesius and Roland Jansson
- You have accessComparing sequenced segments of the tomato and Arabidopsis genomes: Large-scale duplication followed by selective gene loss creates a network of syntenyHsin-Mei Ku, Todd Vision, Jiping Liu, and Steven D. Tanksley
Genetics
- You have accessGenome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarrayTetsuya S. Tanaka, Saied A. Jaradat, Meng K. Lim, George J. Kargul, Xiaohong Wang, Marija J. Grahovac, Serafino Pantano, Yuri Sano, Yulan Piao, Ramaiah Nagaraja, Hirofumi Doi, William H. Wood III, Kevin G. Becker, and Minoru S. H. Ko
- You have accessPrediction, identification, and artificial selection of DNA rearrangements in Rhizobium: Toward a natural genomic designMargarita Flores, Patrick Mavingui, Xavier Perret, William J. Broughton, David Romero, Georgina Hernández, Guillermo Dávila, and Rafael Palacios
- You have accessEngineering blood meal-activated systemic immunity in the yellow fever mosquito, Aedes aegyptiVladimir Kokoza, Abduelaziz Ahmed, Wen-Long Cho, Nijole Jasinskiene, Anthony A. James, and Alexander Raikhel
See companion article:
- You have accessA chromatin insulator protects retrovirus vectors from chromosomal position effectsDavid W. Emery, Evangelia Yannaki, Julie Tubb, and George Stamatoyannopoulos
Immunology
- You have accessB cell maturation protein is a receptor for the tumor necrosis factor family member TALL-1Hong-Bing Shu and Holly Johnson
- You have accessSelective inhibition of HIV replication in primary macrophages but not T lymphocytes by macrophage-derived chemokineManuela Cota, Manuela Mengozzi, Elisa Vicenzi, Paola Panina-Bordignon, Francesco Sinigaglia, Pietro Transidico, Silvano Sozzani, Alberto Mantovani, and Guido Poli
Medical Sciences
- You have accessThe human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5qArndt Borkhardt, Stig Bojesen, Oskar A. Haas, Uta Fuchs, Dominique Bartelheimer, Ivan F. Loncarevic, Rainer M. Bohle, Jochen Harbott, Reinald Repp, Ulrich Jaeger, Susanne Viehmann, Traudl Henn, Petra Korth, Dirk Scharr, and Fritz Lampert
- You have accessThe development of fatal myocarditis and polymyositis in mice heterozygous for IFN-γ and lacking the SOCS-1 geneDonald Metcalf, Ladina Di Rago, Sandra Mifsud, Lynne Hartley, and Warren S. Alexander
- You have accessInhibition of growth and metastatic progression of pancreatic carcinoma in hamster after somatostatin receptor subtype 2 (sst2) gene expression and administration of cytotoxic somatostatin analog AN-238Naoual Benali, Pierre Cordelier, Denis Calise, Philippe Pagès, Philippe Rochaix, Attila Nagy, Jean-Pierre Estève, Parviz M. Pour, Andrew V. Schally, Nicole Vaysse, Christiane Susini, and Louis Buscail
- You have accessIn vivo immunological function of mast cells derived from embryonic stem cells: An approach for the rapid analysis of even embryonic lethal mutations in adult mice in vivoMindy Tsai, Jochen Wedemeyer, Soula Ganiatsas, See-Ying Tam, Leonard I. Zon, and Stephen J. Galli
- You have accessIn vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouseJeffrey S. Schechner, Anjali K. Nath, Lian Zheng, Martin S. Kluger, Christopher C. W. Hughes, M. Rocio Sierra-Honigmann, Marc I. Lorber, George Tellides, Michael Kashgarian, Alfred L. M. Bothwell, and Jordan S. Pober
See companion article:
- Synthesis of organs: In vitro or in vivo?- Aug 08, 2000
- You have accessIn vitro and in vivo evidence for orphan nuclear receptor RORα function in bone metabolismThomas Meyer, Michaela Kneissel, Jean Mariani, and Brigitte Fournier
- You have accessT cell homeostasis in patients with rheumatoid arthritisKerstin Koetz, Ewa Bryl, Kay Spickschen, W. Michael O'Fallon, Jörg J. Goronzy, and Cornelia M. Weyand
- You have accessConditional up-regulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies
- From the Cover
Kanneboyina Nagaraju, Nina Raben, Lisa Loeffler, Tomasina Parker, Paul J. Rochon, Eunice Lee, Carol Danning, Ryuichi Wada, Cynthia Thompson, Gul Bahtiyar, Joseph Craft, Rob Hooft van Huijsduijnen, and Paul PlotzSee companion article:
- B cells in autoimmunity- Aug 01, 2000
- You have accessInactivation of wild-type p53 tumor suppressor by electrophilic prostaglandinsP. J. Moos, K. Edes, and F. A. Fitzpatrick
- You have accessIntratumoral injection of adenoviral vectors encoding tumor-targeted immunoconjugates for cancer immunotherapyZhiwei Hu and Alan Garen
- You have accessPositron emission tomography provides molecular imaging of biological processes
- Inaugural Article
Michael E. Phelps - You have accessCloning and expression of a novel human antibody–antigen pair associated with Felty's syndromeHenrik J. Ditzel, Yasufumi Masaki, Heidi Nielsen, Lauge Farnaes, and Dennis R. Burton
See companion article:
- B cells in autoimmunity- Aug 01, 2000
Microbiology
- You have accessSnapshots of usher-mediated protein secretion and ordered pilus assemblyEvan T. Saulino, Esther Bullitt, and Scott J. Hultgren
- You have accessThe pleiotropic response regulator DegU functions as a priming protein in competence development in Bacillus subtilisLeendert W. Hamoen, Aske F. Van Werkhoven, Gerard Venema, and David Dubnau
- You have accessCoreceptor restriction within the HLA-DQ locus for Epstein–Barr virus infectionKeith M. Haan and Richard Longnecker
- You have accessLipophosphoglycan is a virulence factor distinct from related glycoconjugates in the protozoan parasite Leishmania majorGerald F. Späth, Linda Epstein, Ben Leader, Steven M. Singer, Herbert A. Avila, Salvatore J. Turco, and Stephen M. Beverley
Neurobiology
- You have accessPseudorabies virus expressing enhanced green fluorescent protein: A tool for in vitro electrophysiological analysis of transsynaptically labeled neurons in identified central nervous system circuitsBret N. Smith, Bruce W. Banfield, Cynthia A. Smeraski, Christine L. Wilcox, F. Edward Dudek, Lynn W. Enquist, and Gary E. Pickard
- You have accessNeuroprotective potential of a viral vector system induced by a neurological insultClare R. Ozawa, Jill J. Ho, David J. Tsai, Dora Y. Ho, and Robert M. Sapolsky
- You have accessSubnucleus-specific loss of neurons in medial thalamus of schizophrenicsGregory J. Popken, William E. Bunney Jr., Steven G. Potkin, and Edward G. Jones
- You have accessLearning about pain: The neural substrate of the prediction error for aversive eventsAlexander Ploghaus, Irene Tracey, Stuart Clare, Joseph S. Gati, J. Nicholas P. Rawlins, and Paul M. Matthews
- You have accessSpinophilin regulates the formation and function of dendritic spinesJian Feng, Zhen Yan, Adriana Ferreira, Kazuhito Tomizawa, Jason A. Liauw, Min Zhuo, Patrick B. Allen, Charles C. Ouimet, and Paul Greengard
- You have accessThe role of dynamic palmitoylation in Ca2+ channel inactivationJoyce H. Hurley, Anne L. Cahill, Kevin P. M. Currie, and Aaron P. Fox
- You have accessPresenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid β-protein generationWeiming Xia, William J. Ray, Beth L. Ostaszewski, Talat Rahmati, W. Taylor Kimberly, Michael S. Wolfe, Jimin Zhang, Alison M. Goate, and Dennis J. Selkoe
Pharmacology
- You have accessSpecific binding sites for alcohols and anesthetics on ligand-gated ion channelsMaria Paola Mascia, James R. Trudell, and R. Adron Harris
- You have accessRole of C-terminal domains of the G protein β subunit in the activation of effectorsChang-Seon Myung and James C. Garrison
Physiology
- You have accessInterleukin-6 is an essential, corticotropin-releasing hormone-independent stimulator of the adrenal axis during immune system activationKathleen E. Bethin, Sherri K. Vogt, and Louis J. Muglia
Plant Biology
- You have accessThe Arabidopsis dnd1 “defense, no death” gene encodes a mutated cyclic nucleotide-gated ion channelSteven J. Clough, Kevin A. Fengler, I-ching Yu, Bernadette Lippok, Roger K. Smith Jr., and Andrew F. Bent
- You have accessNew roles for cis-jasmone as an insect semiochemical and in plant defenseMichael A. Birkett, Colin A. M. Campbell, Keith Chamberlain, Emilio Guerrieri, Alastair J. Hick, Janet L. Martin, Michaela Matthes, Johnathan A. Napier, Jan Pettersson, John A. Pickett, Guy M. Poppy, Eleanor M. Pow, Barry J. Pye, Lesley E. Smart, George H. Wadhams, Lester J. Wadhams, and Christine M. Woodcock
Population Biology
- You have accessEtiology of interepidemic periods of mosquito-borne diseaseSimon I. Hay, Monica F. Myers, Donald S. Burke, David W. Vaughn, Timothy Endy, Nisalak Ananda, G. Dennis Shanks, Robert W. Snow, and David J. Rogers
Commentaries
See companion article:
See companion article: