Table of Contents

Biological Sciences

• Agricultural Sciences

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    Bean α-amylase inhibitor 1 in transgenic peas (Pisum sativum) provides complete protection from pea weevil (Bruchus pisorum) under field conditions

    Roger L. Morton, Hart E. Schroeder, Kaye S. Bateman, Maarten J. Chrispeels, Eric Armstrong, and Thomas J. V. Higgins

    PNAS April 11, 2000 97 (8) 3820-3825; https://doi.org/10.1073/pnas.070054597

• Applied Biological Sciences

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    α-Thujone (the active component of absinthe): γ-Aminobutyric acid type A receptor modulation and metabolic detoxification

    Karin M. Höld, Nilantha S. Sirisoma, Tomoko Ikeda, Toshio Narahashi, and John E. Casida

    PNAS April 11, 2000 97 (8) 3826-3831; https://doi.org/10.1073/pnas.070042397

    See companion article:

    • Absinthe and γ-aminobutyric acid receptors

      - Apr 25, 2000

• Biochemistry

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    Removal of oxygen free-radical-induced 5′,8-purine cyclodeoxynucleosides from DNA by the nucleotide excision-repair pathway in human cells

    Isao Kuraoka, Christina Bender, Anthony Romieu, Jean Cadet, Richard D. Wood, and Tomas Lindahl

    PNAS April 11, 2000 97 (8) 3832-3837; https://doi.org/10.1073/pnas.070471597
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    The human DINB1 gene encodes the DNA polymerase Polθ

    Robert E. Johnson, Satya Prakash, and Louise Prakash

    PNAS April 11, 2000 97 (8) 3838-3843; https://doi.org/10.1073/pnas.97.8.3838

    See companion article:

    • The many faces of DNA polymerases: Strategies for mutagenesis and for mutational avoidance

      - May 16, 2000
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    Reevaluation of the accepted allosteric mechanism of phosphofructokinase from Bacillus stearothermophilus

    Jennifer L. Kimmel and Gregory D. Reinhart

    PNAS April 11, 2000 97 (8) 3844-3849; https://doi.org/10.1073/pnas.050588097
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    Bax degradation by the ubiquitin/proteasome-dependent pathway: Involvement in tumor survival and progression

    Benyi Li and Q. Ping Dou

    PNAS April 11, 2000 97 (8) 3850-3855; https://doi.org/10.1073/pnas.070047997
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    Crystal structure of the cystine C-S lyase from Synechocystis: Stabilization of cysteine persulfide for FeS cluster biosynthesis

    Tim Clausen, Jens T. Kaiser, Clemens Steegborn, Robert Huber, and Dorothea Kessler

    PNAS April 11, 2000 97 (8) 3856-3861; https://doi.org/10.1073/pnas.97.8.3856
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    Targeted inhibition of transcription elongation in cells mediated by triplex-forming oligonucleotides

    M. Faria, C. D. Wood, L. Perrouault, J. S. Nelson, A. Winter, M. R. H. White, C. Hélène, and C. Giovannangeli

    PNAS April 11, 2000 97 (8) 3862-3867; https://doi.org/10.1073/pnas.97.8.3862
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    Peptide nucleic acids rather than RNA may have been the first genetic molecule

    Kevin E. Nelson, Matthew Levy, and Stanley L. Miller

    PNAS April 11, 2000 97 (8) 3868-3871; https://doi.org/10.1073/pnas.97.8.3868
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    Enhanced visibility of hydrogen atoms by neutron crystallography on fully deuterated myoglobin

    Fong Shu, Venki Ramakrishnan, and Benno P. Schoenborn

    PNAS April 11, 2000 97 (8) 3872-3877; https://doi.org/10.1073/pnas.060024697
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    Using antibody catalysis to study the outcome of multiple evolutionary trials of a chemical task

    Amelie Karlstrom, Guofu Zhong, Christoph Rader, Nicholas A. Larsen, Andreas Heine, Roberta Fuller, Benjamin List, Fujie Tanaka, Ian A. Wilson, Carlos F. Barbas III, and Richard A. Lerner

    PNAS April 11, 2000 97 (8) 3878-3883; https://doi.org/10.1073/pnas.97.8.3878
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    Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumor model

    Jianmin Fang, Yuen Shing, Dmitri Wiederschain, Li Yan, Catherine Butterfield, Geraldine Jackson, Jay Harper, George Tamvakopoulos, and Marsha A. Moses

    PNAS April 11, 2000 97 (8) 3884-3889; https://doi.org/10.1073/pnas.97.8.3884
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    Effects of saturation mutagenesis of the phage SP6 promoter on transcription activity, presented by activity logos

    Inkyung Shin, Jinsuk Kim, Charles R. Cantor, and Changwon Kang

    PNAS April 11, 2000 97 (8) 3890-3895; https://doi.org/10.1073/pnas.97.8.3890
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    Leading and lagging strand DNA synthesis in vitro by a reconstituted herpes simplex virus type 1 replisome

    Maria Falkenberg, I. R. Lehman, and Per Elias

    PNAS April 11, 2000 97 (8) 3896-3900; https://doi.org/10.1073/pnas.97.8.3896
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    A sequence resembling a peroxisomal targeting sequence directs the interaction between the tetratricopeptide repeats of Ssn6 and the homeodomain of α2

    Rebecca L. Smith and Alexander D. Johnson

    PNAS April 11, 2000 97 (8) 3901-3906; https://doi.org/10.1073/pnas.070506797
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    Crystal structure of native chicken fibrinogen at 5.5-Å resolution

    Zhe Yang, Igor Mochalkin, Leela Veerapandian, Marcia Riley, and Russell F. Doolittle

    PNAS April 11, 2000 97 (8) 3907-3912; https://doi.org/10.1073/pnas.080065697
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    Identification and characterization of a host protein required for efficient template selection in viral RNA replication

    Juana Díez, Masayuki Ishikawa, Masanori Kaido, and Paul Ahlquist

    PNAS April 11, 2000 97 (8) 3913-3918; https://doi.org/10.1073/pnas.080072997
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    Glucocorticoids repress NF-κB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell

    Karolien De Bosscher, Wim Vanden Berghe, Linda Vermeulen, Stéphane Plaisance, Elke Boone, and Guy Haegeman

    PNAS April 11, 2000 97 (8) 3919-3924; https://doi.org/10.1073/pnas.97.8.3919
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    A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor α gene expression

    James V. Falvo, Brigitta M. N. Brinkman, Alla V. Tsytsykova, Eunice Y. Tsai, Tso-Pang Yao, Andrew L. Kung, and Anne E. Goldfeld

    PNAS April 11, 2000 97 (8) 3925-3929; https://doi.org/10.1073/pnas.97.8.3925
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    Activation of gene expression by small molecule transcription factors

    Anna K. Mapp, Aseem Z. Ansari, Mark Ptashne, and Peter B. Dervan

    PNAS April 11, 2000 97 (8) 3930-3935; https://doi.org/10.1073/pnas.97.8.3930
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    Recognition of triple-helical DNA structures by transposon Tn7

    Jason E. Rao, Paul S. Miller, and Nancy L. Craig

    PNAS April 11, 2000 97 (8) 3936-3941; https://doi.org/10.1073/pnas.080061497
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    The Escherichia coli signal transducers PII (GlnB) and GlnK form heterotrimers in vivo: Fine tuning the nitrogen signal cascade

    Wally C. van Heeswijk, Daying Wen, Paula Clancy, Rene Jaggi, David L. Ollis, Hans V. Westerhoff, and Subhash G. Vasudevan

    PNAS April 11, 2000 97 (8) 3942-3947; https://doi.org/10.1073/pnas.97.8.3942
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    Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites

    Shunbin Xiong, Subrahmanyam S. Chirala, and Salih J. Wakil

    PNAS April 11, 2000 97 (8) 3948-3953; https://doi.org/10.1073/pnas.040574197
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    Predicting protein function from structure: Unique structural features of proteases

    Eric W. Stawiski, Albion E. Baucom, Scott C. Lohr, and Lydia M. Gregoret

    PNAS April 11, 2000 97 (8) 3954-3958; https://doi.org/10.1073/pnas.070548997

• Biophysics

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    Carbon nanotube atomic force microscopy tips: Direct growth by chemical vapor deposition and application to high-resolution imaging

    Chin Li Cheung, Jason H. Hafner, and Charles M. Lieber

    PNAS April 11, 2000 97 (8) 3809-3813; https://doi.org/10.1073/pnas.050498597
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    Reversal of charge selectivity in transmembrane protein pores by using noncovalent molecular adapters

    Li-Qun Gu, Mauro Dalla Serra, J. Bryan Vincent, Gyula Vigh, Stephen Cheley, Orit Braha, and Hagan Bayley

    PNAS April 11, 2000 97 (8) 3959-3964; https://doi.org/10.1073/pnas.97.8.3959
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    Predicting ligand-binding function in families of bacterial receptors

    Jason M. Johnson and George M. Church

    PNAS April 11, 2000 97 (8) 3965-3970; https://doi.org/10.1073/pnas.050580897
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    The Holliday junction in an inverted repeat DNA sequence: Sequence effects on the structure of four-way junctions

    Brandt F. Eichman, Jeffrey M. Vargason, Blaine H. M. Mooers, and P. Shing Ho

    PNAS April 11, 2000 97 (8) 3971-3976; https://doi.org/10.1073/pnas.97.8.3971
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    A statistical mechanical method to optimize energy functions for protein folding

    Ugo Bastolla, Michele Vendruscolo, and Ernst-Walter Knapp

    PNAS April 11, 2000 97 (8) 3977-3981; https://doi.org/10.1073/pnas.97.8.3977
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    On the direct determination of three-dimensional crystallographic phases at low resolution: Crambin at 6 Å

    Douglas L. Dorset

    PNAS April 11, 2000 97 (8) 3982-3986; https://doi.org/10.1073/pnas.060019197
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    Osmotic stress, crowding, preferential hydration, and binding: A comparison of perspectives

    V. A. Parsegian, R. P. Rand, and D. C. Rau

    PNAS April 11, 2000 97 (8) 3987-3992; https://doi.org/10.1073/pnas.97.8.3987

• Cell Biology

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    Inhibition of PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) expression by antisense PCDGF cDNA transfection inhibits tumorigenicity of the human breast carcinoma cell line MDA-MB-468

    Runqing Lu and Ginette Serrero

    PNAS April 11, 2000 97 (8) 3993-3998; https://doi.org/10.1073/pnas.97.8.3993
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    MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16

    Bin Zheng, Dan Chen, and Marilyn Gist Farquhar

    PNAS April 11, 2000 97 (8) 3999-4004; https://doi.org/10.1073/pnas.97.8.3999
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    Cadherin interaction probed by atomic force microscopy

    W. Baumgartner, P. Hinterdorfer, W. Ness, A. Raab, D. Vestweber, H. Schindler, and D. Drenckhahn

    PNAS April 11, 2000 97 (8) 4005-4010; https://doi.org/10.1073/pnas.070052697
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    The Arf GTPase-activating protein ASAP1 regulates the actin cytoskeleton

    • From the Cover

    Paul A. Randazzo, Josefa Andrade, Koichi Miura, Megan T. Brown, Ya-Qiu Long, Stacey Stauffer, Peter Roller, and Jonathan A. Cooper

    PNAS April 11, 2000 97 (8) 4011-4016; https://doi.org/10.1073/pnas.070552297

    See companion article:

    • Filling in the GAPs in the ADP-ribosylation factor story

      - Apr 11, 2000
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    The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton

    Anna Rachel Gallagher, Anna Cedzich, Norbert Gretz, Stefan Somlo, and Ralph Witzgall

    PNAS April 11, 2000 97 (8) 4017-4022; https://doi.org/10.1073/pnas.97.8.4017
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    Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression

    Gabriela da Silva Xavier, Isabelle Leclerc, Ian P. Salt, Bruno Doiron, D. Grahame Hardie, Axel Kahn, and Guy A. Rutter

    PNAS April 11, 2000 97 (8) 4023-4028; https://doi.org/10.1073/pnas.97.8.4023
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    clag9: A cytoadherence gene in Plasmodium falciparum essential for binding of parasitized erythrocytes to CD36

    Katharine R. Trenholme, Donald L. Gardiner, Deborah C. Holt, Elizabeth A. Thomas, Alan F. Cowman, and David J. Kemp

    PNAS April 11, 2000 97 (8) 4029-4033; https://doi.org/10.1073/pnas.040561197
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    The p24 proteins are not essential for vesicular transport in Saccharomyces cerevisiae

    • From the Cover

    Sebastian Springer, Eric Chen, Rainer Duden, Martina Marzioch, Adele Rowley, Susan Hamamoto, Sabeeha Merchant, and Randy Schekman

    PNAS April 11, 2000 97 (8) 4034-4039; https://doi.org/10.1073/pnas.070044097

    See companion article:

    • Thinking about p24 proteins and how transport vesicles select their cargo

      - Apr 11, 2000
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    Membrane-associated GAIP is a phosphoprotein and can be phosphorylated by clathrin-coated vesicles

    Thierry Fischer, Eric Elenko, Lei Wan, Gary Thomas, and Marilyn Gist Farquhar

    PNAS April 11, 2000 97 (8) 4040-4045; https://doi.org/10.1073/pnas.97.8.4040
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    SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage

    Yong Mao, Mei Sun, Shyamal D. Desai, and Leroy F. Liu

    PNAS April 11, 2000 97 (8) 4046-4051; https://doi.org/10.1073/pnas.080536597

• Developmental Biology

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    Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I

    Zhongjun Zhou, Suneel S. Apte, Raija Soininen, Renhai Cao, George Y. Baaklini, Richard W. Rauser, Jianming Wang, Yihai Cao, and Karl Tryggvason

    PNAS April 11, 2000 97 (8) 4052-4057; https://doi.org/10.1073/pnas.060037197
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    Stra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC)-dependent and HDAC-independent mechanisms

    Hong Sun and Reshma Taneja

    PNAS April 11, 2000 97 (8) 4058-4063; https://doi.org/10.1073/pnas.070526297
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    Distinct Hox protein sequences determine specificity in different tissues

    Sophie Chauvet, Samir Merabet, David Bilder, Matthew P. Scott, Jacques Pradel, and Yacine Graba

    PNAS April 11, 2000 97 (8) 4064-4069; https://doi.org/10.1073/pnas.070046997
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    Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases

    Jianrong Lu, Timothy A. McKinsey, Rebekka L. Nicol, and Eric N. Olson

    PNAS April 11, 2000 97 (8) 4070-4075; https://doi.org/10.1073/pnas.080064097
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    Action of the Caenorhabditis elegans GATA factor END-1 in Xenopus suggests that similar mechanisms initiate endoderm development in ecdysozoa and vertebrates

    Sarah A. Shoichet, Talat H. Malik, Joel H. Rothman, and Ramesh A. Shivdasani

    PNAS April 11, 2000 97 (8) 4076-4081; https://doi.org/10.1073/pnas.97.8.4076

• Ecology

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    Latitudinal gradients of species richness in the deep-sea benthos of the North Atlantic

    Michael A. Rex, Carol T. Stuart, and Gina Coyne

    PNAS April 11, 2000 97 (8) 4082-4085; https://doi.org/10.1073/pnas.050589497

• Evolution

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    Seed plant phylogeny inferred from all three plant genomes: Monophyly of extant gymnosperms and origin of Gnetales from conifers

    Shu-Miaw Chaw, Christopher L. Parkinson, Yuchang Cheng, Thomas M. Vincent, and Jeffrey D. Palmer

    PNAS April 11, 2000 97 (8) 4086-4091; https://doi.org/10.1073/pnas.97.8.4086
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    Phylogeny of seed plants based on all three genomic compartments: Extant gymnosperms are monophyletic and Gnetales' closest relatives are conifers

    L. Michelle Bowe, Gwénaële Coat, and Claude W. dePamphilis

    PNAS April 11, 2000 97 (8) 4092-4097; https://doi.org/10.1073/pnas.97.8.4092
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    Multiplication of antenna genes as a major adaptation to low light in a marine prokaryote

    Laurence Garczarek, Wolfgang R. Hess, Julia Holtzendorff, Georg W. M. van der Staay, and Frédéric Partensky

    PNAS April 11, 2000 97 (8) 4098-4101; https://doi.org/10.1073/pnas.070040897
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    A lower jaw of Pondaungia cotteri from the Late Middle Eocene Pondaung Formation (Myanmar) confirms its anthropoid status

    Yaowalak Chaimanee, Tin Thein, Stéphane Ducrocq, Aung Naing Soe, Mouloud Benammi, Than Tun, Thit Lwin, San Wai, and Jean-Jacques Jaeger

    PNAS April 11, 2000 97 (8) 4102-4105; https://doi.org/10.1073/pnas.97.8.4102
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    Ecological character displacement in Plethodon: Biomechanical differences found from a geometric morphometric study

    Dean C. Adams and F. James Rohlf

    PNAS April 11, 2000 97 (8) 4106-4111; https://doi.org/10.1073/pnas.97.8.4106

    See companion article:

    • Ecological character displacement and the study of adaptation

      - May 23, 2000
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    Compositional genomes: Prebiotic information transfer in mutually catalytic noncovalent assemblies

    Daniel Segré, Dafna Ben-Eli, and Doron Lancet

    PNAS April 11, 2000 97 (8) 4112-4117; https://doi.org/10.1073/pnas.97.8.4112
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    Riding the ice age El Niño? Pacific biogeography and evolution of Metrosideros subg. Metrosideros (Myrtaceae) inferred from nuclear ribosomal DNA

    • From the Cover

    S. D. Wright, C. G. Yong, J. W. Dawson, D. J. Whittaker, and R. C. Gardner

    PNAS April 11, 2000 97 (8) 4118-4123; https://doi.org/10.1073/pnas.050351197
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    Are variations in cuticular hydrocarbons of queens and workers a reliable signal of fertility in the ant Harpegnathos saltator?

    • Inaugural Article

    Jürgen Liebig, Christian Peeters, Neil J. Oldham, Claus Markstädter, and Bert Hölldobler

    PNAS April 11, 2000 97 (8) 4124-4131; https://doi.org/10.1073/pnas.97.8.4124

• Genetics

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    Genetic mapping of a naturally occurring hereditary renal cancer syndrome in dogs

    Thora J. Jónasdóttir, Cathryn S. Mellersh, Lars Moe, Ragna Heggebø, Hans Gamlem, Elaine A. Ostrander, and Frode Lingaas

    PNAS April 11, 2000 97 (8) 4132-4137; https://doi.org/10.1073/pnas.070053397
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    A causal link between respiration and senescence in Podospora anserina

    Eric Dufour, Joceline Boulay, Vincent Rincheval, and Annie Sainsard-Chanet

    PNAS April 11, 2000 97 (8) 4138-4143; https://doi.org/10.1073/pnas.070501997
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    Rab geranylgeranyl transferase α mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis

    John C. Detter, Qing Zhang, Emilie H. Mules, Edward K. Novak, Vishnu S. Mishra, Wei Li, Elzbieta B. McMurtrie, Velizar T. Tchernev, Margaret R. Wallace, Miguel C. Seabra, Richard T. Swank, and Stephen F. Kingsmore

    PNAS April 11, 2000 97 (8) 4144-4149; https://doi.org/10.1073/pnas.080517697
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    Comparative organization of cattle chromosome 5 revealed by comparative mapping by annotation and sequence similarity and radiation hybrid mapping

    • Inaugural Article

    Akihito Ozawa, Mark R. Band, Joshua H. Larson, Jena Donovan, Cheryl A. Green, James E. Womack, and Harris A. Lewin

    PNAS April 11, 2000 97 (8) 4150-4155; https://doi.org/10.1073/pnas.050007097
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    Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice

    Osamu Minowa, Tsuyoshi Arai, Masanori Hirano, Yoshiaki Monden, Shigeyasu Nakai, Mayuko Fukuda, Masaki Itoh, Hiroshi Takano, Yoshitaka Hippou, Hiroyuki Aburatani, Ken-ichi Masumura, Takehiko Nohmi, Susumu Nishimura, and Tetsuo Noda

    PNAS April 11, 2000 97 (8) 4156-4161; https://doi.org/10.1073/pnas.050404497
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    Screening poly(dA/dT)⁻ cDNAs for gene identification

    • From the Cover

    San Ming Wang, Scott C. Fears, Lin Zhang, Jian-Jun Chen, and Janet D. Rowley

    PNAS April 11, 2000 97 (8) 4162-4167; https://doi.org/10.1073/pnas.97.8.4162

    See companion article:

    • Identifying expressed genes

      - Apr 11, 2000
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    Genome organization in dicots: Genome duplication in Arabidopsis and synteny between soybean and Arabidopsis

    David Grant, Perry Cregan, and Randy C. Shoemaker

    PNAS April 11, 2000 97 (8) 4168-4173; https://doi.org/10.1073/pnas.070430597
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    High metastatic potential in mice inheriting a targeted p53 missense mutation

    Geng Liu, Timothy J. McDonnell, Roberto Montes de Oca Luna, Mini Kapoor, Betsy Mims, Adel K. El-Naggar, and Guillermina Lozano

    PNAS April 11, 2000 97 (8) 4174-4179; https://doi.org/10.1073/pnas.97.8.4174
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    Sox6 is a candidate gene for p^100H myopathy, heart block, and sudden neonatal death

    Nobuko Hagiwara, Scott E. Klewer, Ricardo A. Samson, Drew T. Erickson, Mary F. Lyon, and Murray H. Brilliant

    PNAS April 11, 2000 97 (8) 4180-4185; https://doi.org/10.1073/pnas.97.8.4180
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    The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light

    Peter E. M. Gibbs, Xi-De Wang, Ziqiang Li, Terrence P. McManus, W. Glenn McGregor, Christopher W. Lawrence, and Veronica M. Maher

    PNAS April 11, 2000 97 (8) 4186-4191; https://doi.org/10.1073/pnas.97.8.4186

• Immunology

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    Augmentation of immune responses to HIV-1 and simian immunodeficiency virus DNA vaccines by IL-2/Ig plasmid administration in rhesus monkeys

    Dan H. Barouch, Abie Craiu, Marcelo J. Kuroda, Jörn E. Schmitz, Xin Xiao Zheng, Sampa Santra, Julie D. Frost, Georgia R. Krivulka, Michelle A. Lifton, Carroll L. Crabbs, Gwendolyn Heidecker, Helen C. Perry, Mary-Ellen Davies, Hong Xie, Christine E. Nickerson, Tavis D. Steenbeke, Carol I. Lord, David C. Montefiori, Terry B. Strom, John W. Shiver, Mark G. Lewis, and Norman L. Letvin

    PNAS April 11, 2000 97 (8) 4192-4197; https://doi.org/10.1073/pnas.050417697
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    Serological identification of embryonic neural proteins as highly immunogenic tumor antigens in small cell lung cancer

    Ali O. Güre, Elisabeth Stockert, Matthew J. Scanlan, Roger S. Keresztes, Dirk Jäger, Nasser K. Altorki, Lloyd J. Old, and Yao-Tseng Chen

    PNAS April 11, 2000 97 (8) 4198-4203; https://doi.org/10.1073/pnas.97.8.4198
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    Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice

    Alexandra O. Sousa, Richard J. Mazzaccaro, Robert G. Russell, Francis K. Lee, Oliver C. Turner, Seokmann Hong, Luc Van Kaer, and Barry R. Bloom

    PNAS April 11, 2000 97 (8) 4204-4208; https://doi.org/10.1073/pnas.97.8.4204
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    Retroviral membrane display of apoptotic effector molecules

    David Strehlow, Satoshi Jodo, and Shyr-Te Ju

    PNAS April 11, 2000 97 (8) 4209-4214; https://doi.org/10.1073/pnas.070049197
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    Identification of a human recent thymic emigrant phenotype

    Richard D. McFarland, Daniel C. Douek, Richard A. Koup, and Louis J. Picker

    PNAS April 11, 2000 97 (8) 4215-4220; https://doi.org/10.1073/pnas.070061597

• Medical Sciences

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    Conversion of α-lactalbumin to a protein inducing apoptosis

    M. Svensson, A. Håkansson, A.-K. Mossberg, S. Linse, and C. Svanborg

    PNAS April 11, 2000 97 (8) 4221-4226; https://doi.org/10.1073/pnas.97.8.4221
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    Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo

    Jennifer Rubin Grandis, Stephanie D. Drenning, Qing Zeng, Simon C. Watkins, Mona F. Melhem, Sohei Endo, Daniel E. Johnson, Leaf Huang, Yukai He, and Jae D. Kim

    PNAS April 11, 2000 97 (8) 4227-4232; https://doi.org/10.1073/pnas.97.8.4227
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    Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2

    Xinyi Wu, Karin Hepner, Shobha Castelino-Prabhu, Duc Do, Marc B. Kaye, Xiu-Juan Yuan, Jonathan Wood, Christopher Ross, Charles L. Sawyers, and Young E. Whang

    PNAS April 11, 2000 97 (8) 4233-4238; https://doi.org/10.1073/pnas.97.8.4233
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    Cardiac fibrosis in mice lacking brain natriuretic peptide

    Naohisa Tamura, Yoshihiro Ogawa, Hideki Chusho, Kenji Nakamura, Kazuki Nakao, Michio Suda, Masato Kasahara, Ryuju Hashimoto, Goro Katsuura, Masashi Mukoyama, Hiroshi Itoh, Yoshihiko Saito, Issei Tanaka, Hiroki Otani, Motoya Katsuki, and Kazuwa Nakao

    PNAS April 11, 2000 97 (8) 4239-4244; https://doi.org/10.1073/pnas.070371497
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    High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1

    John McNeish, Robert J. Aiello, Deborah Guyot, Tom Turi, Christopher Gabel, Charles Aldinger, Kenneth L. Hoppe, Marsha L. Roach, Lori J. Royer, Jeffery de Wet, Cyril Broccardo, Giovanna Chimini, and Omar L. Francone

    PNAS April 11, 2000 97 (8) 4245-4250; https://doi.org/10.1073/pnas.97.8.4245
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    Selective in vivo suppression of T lymphocyte responses in experimental measles virus infection

    Stefan Niewiesk, Michaela Götzelmann, and Volker ter Meulen

    PNAS April 11, 2000 97 (8) 4251-4255; https://doi.org/10.1073/pnas.060012097
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    Adenovirus-mediated suppression of HMGI(Y) protein synthesis as potential therapy of human malignant neoplasias

    Stefania Scala, Giuseppe Portella, Monica Fedele, Gennaro Chiappetta, and Alfredo Fusco

    PNAS April 11, 2000 97 (8) 4256-4261; https://doi.org/10.1073/pnas.070029997
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    β-Catenin, a novel prognostic marker for breast cancer: Its roles in cyclin D1 expression and cancer progression

    Shiaw-Yih Lin, Weiya Xia, Jo C. Wang, Ka Yin Kwong, Bill Spohn, Yong Wen, Richard G. Pestell, and Mien-Chie Hung

    PNAS April 11, 2000 97 (8) 4262-4266; https://doi.org/10.1073/pnas.060025397
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    IMP and AMP deaminase in reperfusion injury down-regulates neutrophil recruitment

    Fei-Hua Qiu, Koichiro Wada, Gregory L. Stahl, and Charles N. Serhan

    PNAS April 11, 2000 97 (8) 4267-4272; https://doi.org/10.1073/pnas.97.8.4267
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    Destabilization of osteogenesis imperfecta collagen-like model peptides correlates with the identity of the residue replacing glycine

    Konrad Beck, Virginia C. Chan, Nigel Shenoy, Alan Kirkpatrick, John A. M. Ramshaw, and Barbara Brodsky

    PNAS April 11, 2000 97 (8) 4273-4278; https://doi.org/10.1073/pnas.070050097
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    Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: Contribution of the DHEAge Study to a sociobiomedical issue

    Etienne-Emile Baulieu, Guy Thomas, Sylvie Legrain, Najiba Lahlou, Marc Roger, Brigitte Debuire, Veronique Faucounau, Laurence Girard, Marie-Pierre Hervy, Florence Latour, Marie-Céline Leaud, Amina Mokrane, Hélène Pitti-Ferrandi, Christophe Trivalle, Olivier de Lacharrière, Stephanie Nouveau, Brigitte Rakoto-Arison, Jean-Claude Souberbielle, Jocelyne Raison, Yves Le Bouc, Agathe Raynaud, Xavier Girerd, and Françoise Forette

    PNAS April 11, 2000 97 (8) 4279-4284; https://doi.org/10.1073/pnas.97.8.4279
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    The immunosuppressive macrolide RAD inhibits growth of human Epstein–Barr virus-transformed B lymphocytes in vitro and in vivo: A potential approach to prevention and treatment of posttransplant lymphoproliferative disorders

    Miroslaw Majewski, Magdalena Korecka, Plamen Kossev, Shiyong Li, June Goldman, Jonni Moore, Leslie E. Silberstein, Peter C. Nowell, Walter Schuler, Leslie M. Shaw, and Mariusz A. Wasik

    PNAS April 11, 2000 97 (8) 4285-4290; https://doi.org/10.1073/pnas.080068597
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    Effects of p21^{Waf1/Cip1/Sdi1} on cellular gene expression: Implications for carcinogenesis, senescence, and age-related diseases

    Bey-Dih Chang, Keiko Watanabe, Eugenia V. Broude, Jing Fang, Jason C. Poole, Tatiana V. Kalinichenko, and Igor B. Roninson

    PNAS April 11, 2000 97 (8) 4291-4296; https://doi.org/10.1073/pnas.97.8.4291

• Microbiology

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    Genetic evidence that the bacteriophage φX174 lysis protein inhibits cell wall synthesis

    Thomas G. Bernhardt, William D. Roof, and Ry Young

    PNAS April 11, 2000 97 (8) 4297-4302; https://doi.org/10.1073/pnas.97.8.4297
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    Heteroduplex mobility assay-guided sequence discovery: Elucidation of the small subunit (18S) rDNA sequences of Pfiesteria piscicida and related dinoflagellates from complex algal culture and environmental sample DNA pools

    David W. Oldach, Charles F. Delwiche, Kjetill S. Jakobsen, Torstein Tengs, Ernest G. Brown, Jason W. Kempton, Eric F. Schaefer, Holly A. Bowers, Howard B. Glasgow Jr., JoAnn M. Burkholder, Karen A. Steidinger, and Parke A. Rublee

    PNAS April 11, 2000 97 (8) 4303-4308; https://doi.org/10.1073/pnas.97.8.4303
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    Influenza A and B viruses expressing altered NS1 proteins: A vaccine approach

    Julie Talon, Mirella Salvatore, Robert E. O'Neill, Yurie Nakaya, Hongyong Zheng, Thomas Muster, Adolfo García-Sastre, and Peter Palese

    PNAS April 11, 2000 97 (8) 4309-4314; https://doi.org/10.1073/pnas.070525997

• Neurobiology

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    Brain-derived neurotrophic factor restores long-term potentiation in polysialic acid-neural cell adhesion molecule-deficient hippocampus

    D. Muller, Z. Djebbara-Hannas, P. Jourdain, L. Vutskits, P. Durbec, G. Rougon, and J. Z. Kiss

    PNAS April 11, 2000 97 (8) 4315-4320; https://doi.org/10.1073/pnas.070022697
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    Control of cocaine-seeking behavior by drug-associated stimuli in rats: Effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens

    Friedbert Weiss, Carmen S. Maldonado-Vlaar, Loren H. Parsons, Tony M. Kerr, Diana L. Smith, and Osnat Ben-Shahar

    PNAS April 11, 2000 97 (8) 4321-4326; https://doi.org/10.1073/pnas.97.8.4321
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    The synaptic glycoprotein neuroplastin is involved in long-term potentiation at hippocampal CA1 synapses

    K. -H. Smalla, H. Matthies, K. Langnäse, S. Shabir, T. M. Böckers, U. Wyneken, S. Staak, M. Krug, P. W. Beesley, and E. D. Gundelfinger

    PNAS April 11, 2000 97 (8) 4327-4332; https://doi.org/10.1073/pnas.080389297
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    KCNQ4, a K⁺ channel mutated in a form of dominant deafness, is expressed in the inner ear and the central auditory pathway

    • From the Cover

    Tatjana Kharkovets, Jean-Pierre Hardelin, Saaid Safieddine, Michaela Schweizer, Aziz El-Amraoui, Christine Petit, and Thomas J. Jentsch

    PNAS April 11, 2000 97 (8) 4333-4338; https://doi.org/10.1073/pnas.97.8.4333

    See companion article:

    • Mutant ion channel in cochlear hair cells causes deafness

      - Apr 11, 2000
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    Asynchronous oscillations of two zebrafish CLOCK partners reveal differential clock control and function

    Nicolas Cermakian, David Whitmore, Nicholas S. Foulkes, and Paolo Sassone-Corsi

    PNAS April 11, 2000 97 (8) 4339-4344; https://doi.org/10.1073/pnas.97.8.4339
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    Damage-induced neuronal endopeptidase (DINE) is a unique metallopeptidase expressed in response to neuronal damage and activates superoxide scavengers

    Sumiko Kiryu-Seo, Masahiko Sasaki, Hiroya Yokohama, Saya Nakagomi, Teruhisa Hirayama, Shunsuke Aoki, Keiji Wada, and Hiroshi Kiyama

    PNAS April 11, 2000 97 (8) 4345-4350; https://doi.org/10.1073/pnas.070509897
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    Impairment of synaptic transmission by transient hypoxia in hippocampal slices: Improved recovery in glutathione peroxidase transgenic mice

    Denis Furling, Othman Ghribi, Ahmed Lahsaini, Marc-Edouard Mirault, and Guy Massicotte

    PNAS April 11, 2000 97 (8) 4351-4356; https://doi.org/10.1073/pnas.060574597
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    Expression of α_1D subunit mRNA is correlated with L-type Ca²⁺ channel activity in single neurons of hippocampal “zipper” slices

    K. C. Chen, E. M. Blalock, O. Thibault, P. Kaminker, and P. W. Landfield

    PNAS April 11, 2000 97 (8) 4357-4362; https://doi.org/10.1073/pnas.070056097

• Pharmacology

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    Ligand-dependent interactions of coactivators steroid receptor coactivator-1 and peroxisome proliferator-activated receptor binding protein with nuclear hormone receptors can be imaged in live cells and are required for transcription

    Juan Llopis, Stefan Westin, Mercedes Ricote, Jiahong Wang, Charles Y. Cho, Riki Kurokawa, Tina-Marie Mullen, David W. Rose, Michael G. Rosenfeld, Roger Y. Tsien, and Christopher K. Glass

    PNAS April 11, 2000 97 (8) 4363-4368; https://doi.org/10.1073/pnas.97.8.4363
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    A genetic model defines the importance of the atrial natriuretic peptide receptor (guanylyl cyclase-A) in the regulation of kidney function

    Susan K. Dubois, Ichiro Kishimoto, Terence O. Lillis, and David L. Garbers

    PNAS April 11, 2000 97 (8) 4369-4373; https://doi.org/10.1073/pnas.97.8.4369

• Physiology

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    NADPH oxidase is an O₂ sensor in airway chemoreceptors: Evidence from K⁺ current modulation in wild-type and oxidase-deficient mice

    Xiao Wen Fu, Dashou Wang, Colin A. Nurse, Mary C. Dinauer, and Ernest Cutz

    PNAS April 11, 2000 97 (8) 4374-4379; https://doi.org/10.1073/pnas.97.8.4374
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    Involvement of multiple intracellular release channels in calcium sparks of skeletal muscle

    A. González, W. G. Kirsch, N. Shirokova, G. Pizarro, G. Brum, I. N. Pessah, M. D. Stern, H. Cheng, and E. Ríos

    PNAS April 11, 2000 97 (8) 4380-4385; https://doi.org/10.1073/pnas.070056497
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    Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels

    Tonghui Ma, Yuanlin Song, Baoxue Yang, Annemarie Gillespie, Elaine J. Carlson, Charles J. Epstein, and A. S. Verkman

    PNAS April 11, 2000 97 (8) 4386-4391; https://doi.org/10.1073/pnas.080499597

• Plant Biology

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    Mutants of Arabidopsis thaliana defective in the acquisition of tolerance to high temperature stress

    Suk-Whan Hong and Elizabeth Vierling

    PNAS April 11, 2000 97 (8) 4392-4397; https://doi.org/10.1073/pnas.97.8.4392

• Psychology

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    Navigation-related structural change in the hippocampi of taxi drivers

    Eleanor A. Maguire, David G. Gadian, Ingrid S. Johnsrude, Catriona D. Good, John Ashburner, Richard S. J. Frackowiak, and Christopher D. Frith

    PNAS April 11, 2000 97 (8) 4398-4403; https://doi.org/10.1073/pnas.070039597

    See companion article:

    • Brain growth and the cognitive map

      - Apr 25, 2000